CMSDLD - Research Seminar Series

The Research Seminars are hour-long formal research seminars every Thursday, featuring a mix of speakers including a) outside investigators who work in gastroenterology and hepatology; b) Center members; c) pilot project awardees; and d) Penn faculty with research programs outside of gastroenterology and hepatology who expose CMSDLD members to new approaches and techniques and who may inspire unexpected collaborations or new directions.

December:

  • December 16, 2021 - Jonathan P. Katz, MD - "TBA"
  • December 9, 2021 - Janelle Corrinne Arthur, PhD - "Gut microbiome and inflammation –associated disease”
  • December 2, 2021 - Christopher J. Lengner, BS, PhD - "TBA'

November

  • November 18, 2021 - Andrew S. Neish, MD - "Microbiota effects on GI physiology and metabolism"

  • November 11, 2021 - Karen Piper Hanley, PhD - "TBA"

  • November 4, 2021 - Ellen Puré, PhD - "Implications of Spatiotemporal Heterogeneity of Stromal Cells and Matrix Remodeling for Pancreatic Cancer Progression and Therapy"

October

  • October 28, 2021 - Markus Grompe, MD - "Hepatocyte Ploidy Dynamics in Liver Regeneration and Cancer"
  • October 21 - 2021 - Pierre-Emanuel Rautou, MD, PhD - "Role of Endothelial Cells in Fatty Liver Diseases"
  • October 14, 2021 - Tracey Simon, MD, MPH - “Novel HCC Prevention Strategies”
  • October 7, 2021 - Emma Andersson - “From DUCT to NEPTUNE: novel technologies to manipulate development and decipher mechanisms of regeneration”

September

  • September 30, 2021 - Amiram Ariel, MSc, PhD - “New molecular and cellular effectors in resolving inflammation and fibrosis”

  • September 23, 2021 - Marino Zerial - “Mechanisms of hepatocyte polarization and liver tissue morphogenesis”

  • September 16, 2021 - Michele T. Pritchard, PhD - "Understanding hyaluronan’s contribution to ethanol-enhanced hepatic stellate cell activation after toxin-induced Liver injury"

June

  • June 24, 2021 - Paul Carlson Jr., PhD - “Clostridioides difficile Pathogenesis and Associated Microbiome Based Therapeutics”

  • June 17, 2021 - Casey M. Theriot, Ph.D. - "Leveraging Lactobacillus Bile Salt Hydrolases for Rational Design of the Gut Microbiota and Prevention of C. difficile

  • June 10, 2021 - Samuel Asfaha, MD, PhD - “Intestinal stem cells and colorectal cancer”

  • June 3, 2021 - Reginald Hill, PhD - "Investigating the Role of the ECM in Exosome-mediated Chemoresistance in Pancreatic Cancer”

May

  • May 27, 2021 - Melanie G. Gareau, PhD - “Neonatal dysbiosis disrupts the development of the microbiota-gut-brain axis”

  • May 20, 2021 - Silvia Vilarinho, MD, PhD - “Genes, Genomes and Liver Disease”

  • May 13, 2021 - Ben Stanger, MD PhD - “Embracing tumor heterogeneity with mouse models of pancreas cancer”

  • May 6, 2021 - Suzanne Devkota - “Uncovering a microbial mechanism for creeping fat in Crohn’s disease”

April

  • April 29, 2021 - Kaufman Lectureship - Talia Golan, MD - “BRCA-associated Pancreatic Cancer”

  • April 22, 2021 - Kristen C. Sadler Edepli, M.M.Sc, PhD - “An epigenetic code regulating liver regeneration”

  • April 15, 2021 - Kathryn Hamilton, PhD - "IMP-licatingRNA binding proteins in intestinal regeneration"

  • April 8, 2021 - Martin J. Blaser, MD - "Immunologic consequences of perturbing the early-life microbiome”

  • April 1, 2021 - Christian Jobin, PhD - "Intestinal Microbiota and Cancer. More than meets the eye”

March

  • March 25, 2021 - Elke Ober - “Building an organ: From progenitors to a functional hepato-biliary system”

  • March 11, 2021 - Neil Henderson, MRCP, PhD, FRCP - "Using single cell genomics to decode the human hepatic fibrotic niche”

  • March 4, 2021 - Hyun (Michel) Koo, DDS, MS, PhD - "Spatial organization of polymicrobial oral communities in disease"

February

  • February 25, 2021 - Takanori Takebe, MD, PhD - "Modeling human hepato-biliary development and disease"

  • February 18, 2021 - Rebecca G. Wells, MD - “Stress from all sides: the mechanics of liver fibrosis and fatty liver disease”

  • February 4, 2021 - Josephine Ni, MD - “Determinants of bacterial biofilm formation at the intestinal mucosal interface and their roles in pathogen exclusion”

January

  • January 21, 2021 - Moira Hilscher, MD - “Mechanocrine signaling drives portal hypertension through neutrophil activation.”
  • January 14, 2021 - Benjamin Voight, PhD - “Casual inference studies for hepatic traits via Mendelian”

December

  • December 10, 2020 - Amanda Muir, MD - "Esophageal epithelial progenitor cells in eosinophilic esophagitis"
  • December 3, 2020 - Kyong-Mi Chang, MD - "Visualizing the complex hepatic immune microenvironment in chronic hepatitis B using imaging mass cytometry"

November

  • November 19, 2020 - Judith Kelsen, MD - "Very early Onset Inflammatory Bowel Disease: A Model for Personalized Medicine in IBD"
  • November 5, 2020 - Kirk J. Wangensteen, MD, PhD - “CRISPR screening in vivo uncovers genes required for liver repopulation and tumorigenesis ”

October

  • October 29, 2020 - De’BroskiHerbert, PhD - “Clarifying the controversial role of IL-33 in IBD pathogenesis”
  • October 22, 2020 - Jeffrey Morris, PhD - “HepatoScore: new biological blood signature for hepatocellular carcinoma”
  • October 15, 2020 - Gary D. Wu, MD - “Lessons learned from studying the impact of diet on the human gut microbiome”
  • October 8, 2020 - Marijana Vujkovic, PhD - “Identifying Novel Genetic Loci of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Million Veteran Program”

March

  • March 12, 2020 - Vesselin Tomov, MD, PhD - “Immune phenotyping of T cells in IBD”

February

  • February 27, 2020 - Patrick Seale, PhD - “Metabolic regulation of progenitor cell fate”
  • February 20, 2020 - Alex Hughes, PhD - “Kidney tissue engineering by developmental mimicry”
  • February 13, 2020 - Edna Cukierman, PhD - “ONCOGENIC SYNAPSES: Stromal Regulators of Pancreatic Cancer Metabolic Support & Innate Immunosuppression”
  • February 6, 2020 - Pranoti Mandrekar, MS, PhD - “Stress’ingthe ProteostasisNetwork in Alcoholic Steathohepatitisand Fibrosis”

January

  • January 23, 2020 - Yasuko Iwakiri, PhD - "The Role of Lymphatic Vessels in Liver Disease"
  • January 16, 2020 - E. Michael Ostap, PhD - "Unexpected roles for cytoskeletal motors – from force sensing, to anchoring, to chirality"

 

December

  • December 19, 2019 - Melike Lakadamyali, PhD - “Super-resolution imaging chromatin organization and dynamics”
  • December 12, 2019 - Jerrold R. Turner, MD, PhD - “Tight Junction Channelopathy: A New Class of Mucosal Disease”
  • December 5, 2019 - Sydney Shaffer, MD, PhD - “Single-cell plasticity and drug resistance in cancer”

November

  • November 21, 2019 - Joseph P. Zackular, PhD - “Mapping pathogen-microbiota interactions during Clostridium difficile infection”
  • November 14, 2019 - Michele A. Battle, PhD - “Novel Roles for GATA Factors in the Gastrointestinal Tract Homeostasis and Disease”

October

  • October 31, 2019 - Garret A. FitzGerald, MD - “Prostaglandins and their inhibitors”
  • October 24, 2019 - Matthew R. Hayes, PhD - “Gut-to-brainstem cellular substrates mediating the anorectic effects of GLP-1 receptor agonists”
  • October 17, 2019 - Laurie D. DeLeve, MD, PhD - “Hepatic Fibrosis-Failure to Communicate”
  • October 10, 2019 - David B. Weiner, PhD - “Advancing Synthetic DNA Technology for Difficult Disease Targets”

September

  • September 26, 2019 - Elizabeth M. Lennon, PhD, DVM - “The Mast Cell in Inflammatory Bowel Disease: Friend or Foe?”
  • September 19, 2019 - Mark L. Kahn, MD - “The gut microbiome in regulation of cerebrovascular and GI lymphatic function”
  • September 5, 2019 - Arianne L. Theiss, PhD - “Mitochondrial dysfunction triggers intestinal inflammation”

May

  • May 2, 2019 - Ning Li, MD - “Plasticity of Enteroendocrinecells during regeneration”

April

  • April 18, 2019 - Kathleen E. Sullivan, MD, PhD - “Very early onset IBD, ins and outs and ups and downs”
  • April 11, 2019 - Roger A. Greenberg, MD, PhD - “BRCA DNA Damage Response Functions”

March

  • March 14, 2019 - Gail Hecht, MD - “Lessons from EPEC about Host Epithelial Physiology”
  • March 7, 2019 - Golnaz, Vahedi, MSc, PhD - “Genetic predisposition to type 1 diabetes leads to chromatin misfolding”

February

  • February 28, 2019 - Karen L. Edelblum, PhD - “Gamma delta intraepithelial lymphocytes and maintenance of intestinal epithelial barrier”
  • February 14, 2019 - Josephine Ni, MD - “Determinants of bacterial biofilm formation at the intestinal mucosal interface and their roles in pathogen exclusion”
  • February 7, 2019 - Ning Li, MD - “Plasticity of Enteroendocrinecells during regeneration”

January

  • January 31, 2019 - Warren S. Pear, MD, PhD - “Tribbles–from Star Trek to immune response”
  • January 24, 2019 - Ronald DeMatteo, MD - “Exploiting immune and molecular features of GIST”
  • January 17, 2019 - Erica L. Carpenter, MBA, PhD - “Comprehensive liquid biopsy approaches for diagnosis and monitoring of pancreatic cancer”
  • January 10, 2019 - Michael C. Abt, PhD - “Immune Microbiota interactions regulate host defense against C. difficile”

December

  • December 13, 2018 - Natalie Terry, MD, PhD - “Enteroendocrinelineage, lipid absorption and microbioaldiversity”
  • December 6, 2018 - Christoph A. Thaiss, PhD - “Environmental impacts on the host-microbiome interface”

November

  • November 29, 2018 - Josephine Ni, MD - “Nitrogen sensing and effects on colonization by E. coli in the intestinal tract”
  • November 15, 2018 - Eric S. Witze, PhD - “Regulation of EGFR signaling by protein palmitoylationin cancer”
  • November 8, 2018 - J. Kevin Foskett, PhD - “Calcium addiction of cancer cells”
  • November 1, 2018 - Ezra Burstein, MD,PhD - “Contributions to the tumor microenvironment in the intestinal tract”

October

  • October 25, 2018 - Xiaolu Yang, PhD - “Control of the embryonic stem cell state by metabolism”
  • October 18, 2018 - Harry Janssen, MD, PhD - “Can hepatitis B ever be cured? First clinical steps using new compounds and biomarkers”
  • October 11, 2018 - Maayan Levy, PhD - “A new player in intestinal epithelial immunity”

September

  • September 20, 2018 - M. Andres Blanco, PhD - “The epigenetic basis of myeloid cell fate decisions”
  • September 13, 2018 - Tzipora Sarah Karin Eisinger, PhD - “Deregulation of the Hippo pathway resets the clock in sarcoma”
  • September 6, 2018 -Laura E. Nagy, PhD - “MicroRNA profiling of hepatic macrophages in models of ALD”

July

  • July 12, 2018 -Sahar Nissim, MD, PhD - “Discovery, Validation, and Characterization of a Novel Hereditary Pancreatic Cancer Gene”

May

  • May 24, 2018 - Kelly Whelan, PhD - “Mechanisms of esophageal homeostasis: Implications for improving patient outcomes in food allergy and cancer"
  • May 10, 2018 - Bryson Katona, MD, PhD - “Uncovering novel roles of menin in colon cancer”
  • May 3, 2018 - Andrei Thomas Tikhonenko, PhD - “TGFbeta signaling in colorectal cancer”

April

  • April 19, 2018 - Hugo R. Rosen, MD - “What are the remaining immunologic questions in hepatitis C? In Fatty liver disease?”
  • April 12, 2018 - Nicholas J. Hand , PhD - “MicroRNAs in liver development and disease”
  • April 5, 2018 - Christina Twyman Saint Victor, MD, MTR - “Improving Response to Immune Checkpoint Blockers in Melanoma and Pancreatic Adenocarcinoma”

March

  • March 29, 2018 - Marcia Cruz Correa, MD, PhD - “Gastric Cancer: Prevention & Diagnosis”
  • March 22, 2018 - Ezra Burstein, MD, PhD - “Epithelial differentiation and immune function in the gastrointestinal mucosa”
  • March 8, 2018 - Kathryn E. Wellen, PhD - “Metabolism, epigenetics, and tumorigenesis”
  • March 1, 2018 - Ana Gamero, PhD - “The transcription factor STAT2: An unexpected accomplice in colon carcinogenesis”

February

  • February 22, 2018 - Seung Kim, MD, PhD - "Intercellular signaling at the nexus of diabetes, chronic pancreatitis and pancreatic cancer: the legacy of our hungry ancestors
  • February 15, 2018 - Ravikanth Maddipati, MD - “The origins of metastasis in pancreatic cancer: a colorful tale”
  • February 8, 2018 - Kathryn Wellen, PhD - “Metabolism, epigenetics and tumorigenesis”

January

  • January 25, 2018 - Boris Striepen, PhD - “Molecular approaches to cryptosporidiosis a leading cause of severe diarrhea and child mortality”
  • January 18, 2018 - Michael P. Verzi, PhD - “Epigenomics of Intestinal Development and Disease”
  • January 11, 2018 - Eric J. Brown, PhD - “Replication stress responses as cancer treatment targets”
  • January 4, 2018 - Karen E. Knudsen, PhD - “Targeting cell cycle dysfunction in advanced prostate cancer”

December

  • December 21, 2017 - Klaus H. Kaestner, PhD - “The Intestinal Stem Cell Niche The Final Answer”
  • December 14, 2017 - Daniel P. Beiting, PhD - “MicrobiomeDB : a systems biology toolkit for integrating, mining and analyzing public microbiome experiments”
  • December 7, 2017 - Andrew D. Patterson, PhD - “Intestinal Epithelial Cell Receptors as Moderators of Host Microbiota Communication”

November

  • November 16, 2017 - Zachary Schug, PhD - “Acetate metabolism in cancer”
  • November 2, 2017 - Ronen Marmorstein, PhD - “Structure-based development of BRAF kinase dimer inhibitors”

October

  • October 26, 2017 - Ulrich Beuers, MD, PhD - “The biliary bicarbonate umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies”
  • October 19, 2017 - Michael Lampson, PhD - “Optogenetic control of cell biology: insights into mitotic chromosome segregation”
  • October 12, 2017 - Gregory Gores, MD - “Inflammatory Extracellular Vesicles in NASH Pathogenesis”
  • October 5, 2017 - Bruce L. Levine, PhD - “Chimeric Antigen Receptor (CAR)T Cells for Malignancy: Development of a First In Class Therapy”

September

  • September 28, 2017 - Clara Abraham, MD - “Innate Immune Dysregulation in Inflammatory Bowel Disease”
  • September 21, 2017 - Yana Kamberov, PhD - “A conserved genetic circuit in skin and neural development and its role in human evolution”
  • September 7, 2017 - Averil Ma, MD - “The Ubiquitous Nature of Human Disease ”

June

  • June 8, 2017 - Sandra W. Ryeom, PhD - “Oncogenic KRAS and p53 loss drive gastric tumorigenesis in a new mouse model of gastric cancer and can be attenuated by E-cadherin expression”
  • June 1, 2017 - Ellen Puré, PhD - “Honing in on stroma-dependent mechanisms that promote tumorigenesis and metastasis”

May

  • May 25, 2017 - Premal Shah, B. Tech, PhD - “Dynamics and evolution of translational regulation”

April

  • April 27, 2017 - Richard K. Assoian, PhD - “Sensing and remodeling ECM and tissue stiffness”
  • April 13, 2017 - M. Celeste Simon, PhD - “Hypoxic Influences on Cancers of the Pancreas and Kidney”
  • April 6, 2017 - Peter Klein, MD, PhD - “Interplay between Wnt and mTOR signaling in somatic stem cell homeostasis”

March

  • March 30, 2017 - Hao Wu, PhD - “Charting DNA (de)methylome in mammalian stem cells and development”
  • March 23, 2017 - Andy Minn, MD, PhD - “Opposing Roles of Interferon Signaling in Regulating Response to Cancer Immune Checkpoint Blockade”
  • March 9, 2017 - Alessio Fasano, MD - “Nutrition, microbiome, gut permeability, and pathogenesis of chronic inflammatory diseases: the Celiac disease paradigm”
  • March 2, 2017 - David E. Cohen, MD, PhD - “Hepatic Fatty Acid Channeling as a Target in the Management of Non-Alcoholic Fatty Liver Disease”

February

  • February 27, 2017 - Kirk Wangensteen, MD, PhD - “Novel Genetic Approaches to Elucidate the Mechanisms of Liver Regeneration and Cancer”
  • February 23, 2017 - Guillermina Lozano, PhD - “p53 function and dysfunction”
  • February 16, 2017 - Rajan Jain, MD - “Mechanisms establishing and maintaining cellular identity”
  • February 9, 2017 - Gloria Su, PhD - “Lessons learned from mouse modeling for human pancreatic cancer”
  • February 2, 2017 - Raymond Soccio, MD, PhD - “PPARs: Regulatory Genetic Variation and Fatty Liver Disease”

January

  • January 26, 2017 - Maureen Murphy, PhD - “An African-specific variant of the p53 tumor suppressor gene predisposes to liver and other cancers”
  • January 19, 2017 - MickolasPapadopoulos, PhD - “Harnessing the Information from Cancer Genomes: From Genomic Landscapes to Liquid Biopsies”
  • January 12, 2017 - Paul Gadue, PhD - “Using human pluripotent stem cells to model monogenic forms of diabetes”
  • January 5, 2017 - Kojo Elenitoba-Johnson, MD - “Mass spectrometry as a driver of discovery in MALT lymphoma pathogenesis”

December

  • December 22, 2016 - Constantinos Koumenis, PhD - “A novel mouse model to study image-guided, radiation-induced intestinal injury and preclinical screening of radioprotectors”
  • December 15, 2016 - Wei Guo, PhD - “Exosomes in Tumorigenesis and Immunosuppression”
  • December 8, 2016 - Montserrat Anguera, PhD, BA - “Unusual maintenance of X-chromosome Inactivation in female lymphocytes: a novel parameter for understanding female-biased autoimmune disorders”
  • December 1, 2016 - Jay Horton, MD - “Molecular Mediators of Lipogenesis in NAFLD”

November

  • November 17, 2016 - Michael P. Verzi, PhD - “Epigenomics of Intestinal Development and Disease”
  • November 10, 2016 - Jeffrey D. Winkler, PhD - “Synthesis of Natural and Unnatural Products”
  • November 3, 2016 - Pantelis Rompolas, PhD - “Mechanisms of cell fate in epidermal maintenance, regeneration and tumorigenesis”

October

  • October 20, 2016 - Junwei Shi, PhD - “Liver cancer target identification using functional genetic approaches”
  • October 13, 2016 - Konstantinos Drosatos, MSc, PhD - “Kruppel-like factor 5:How a cardiomyocyte protein regulates systemic metabolism”
  • October 6, 2016 - De’Broski R. Herbert, PhD - “Trefoil Factor Family Proteins Promote Lung Regeneration and Type 2 Responses”

September

  • September 15, 2016 - Phong Tran, PhD - “New aspects of cell polarity and cell division”
  • September 8, 2016 - Patrick Viatour, MSc, PhD - “Liver Cancer: A Tale of Two Ends”

June

  • June 23, 2016 - Xiao Zhao, MD - “The role of redox signaling in toxin—induced biliary atresia”
  • June 9, 2016 - Bryson Katona, MD, PhD - “Menin in colon cancer: An unexpected journey”
  • June 2, 2016 - David Shen, MD - The Role of Gut Microbiota Urease in Mammalian Host Nitrogen Metabolism”

May

  • May 5, 2016 - Qihong Huang, MD, PhD - Significance of RNA editing in tumor metastasis”

April

  • April 28, 2016 - Xianxin Hua, MD, PhD - “CAR T project on neuroendocrine tumor”
  • April 21, 2016 - Richard Gregory, PhD - “RNA Regulation in Stem Cells and Disease”
  • April 14, 2016 - Scott Magness, PhD - “Intestinal Stem Cells: Drivers of innovative high-throughput organoid analysis and biomimetic gut cultures”