CMSDLD - Research Seminar Series

January 11, 2024
Caroline Bartman, PhD
Perelman School of Medicine
"Slow energy metabolism in primary solid tumors"

January 18, 2024
Jina Ko, PhD
Perelman School of Medicine
"Single Biomarker Profiling for Molecular Diagnostics"

January 25, 2024
Liver Club

February 1, 2024
Ask The Clinician
Jonathan Nahas, MD
Univ of Pennsylvania
Perelman School of Medicine
Christine Chan, MD
Hospital of the University of Pennsylvania
"Ask the Clinician: Steatotic Liver Disease"

February 8, 2024
Amber Alhadeff, PhD
Monell Chemical Senses
Center Dept. of Neuroscience, Univ of Pennsylvania
"The power of hunger"

February 15, 2024
Liver Club

February 22, 2024
Guillaume De Lartigue, PhD
Monell Chemical Senses Center
"Why do we eat foods that we know are bad for us?"

February 29, 2024
Kelley Weinfurtner, MD
University of Pennsylvania
"Developing Precision Medicine Strategies in Hepatocellular Carcinoma"

March 7, 2024
Ask The Clinician
Fatan Aberra, MD, MSCE
University of Pennsylvania

Nabeel Khan, MD
University of Pennsylvania
Topic: IBD

March 14, 2024
TBD

March 21, 2024
Liver Club

March 28, 2024
Jesse Platt, MD
TBD

April 4, 2024
Andrew Hryckowian, PhD
University of Wisconsin-Madison
"Butyrate-imposed tradeoffs in C. difficile metabolism and pathogenesis"

April 11, 2024
Arthur Beyder, MD, PhD
Mayo
"The Mechanosensing Gut: A Touching Story of Age, Stiffness, and Mechanogated Ion Channels"

April 18, 2024
Liver Club

April 25, 2024
Çağla Tükel, PhD
Temple University
"Pathogenic bacterial biofilms in the gut"

May 2, 2024
The P30 Center in partnership with the Center for Innovation & Precision Dentistry
TBD

May 9, 2024
Carla Nowosad, PhD
New York Univ
TBD

May 16, 2024
Nick Hand, PhD
Perelman School of Medicine, Univ of Pennsylvania
TBD

May 23, 2024
Liver Club

May 30, 2024
Mark Frey, PhD
Univ of Southern California
TBD

June 6, 2024
TBD

June 13, 2024
TBD

June 20, 2024
Liver Club

June 27, 2024
Siew Ng
Chinese Univ of Hong Kong
Virtual only
TBD

December:

• December 7, 2023 - Stacey Huppert - "Hepatic Epithelial Cell Plasticity - Identify and Commitment"
• December 14, 2023 - Rebecca Haeusler - "Insulin signaling and hepatic functions in health and disease"
• December 21, 2023 - Liver Biology Club

November:

• November 2, 2023 - Romina Fiorotto - "Innate Immunity and gut-liver axis play tag in Cystic Fibrosis related liver disease"
• November 9, 2023 - Greg Beatty - "TBD"
• November 16, 2023 - Ian Rowe - "Modeling progression and therapeutic impacts in liver disease"
• November 30, 2023 - Jessie Torgersen - "Applications of Artificial Intelligence Tools to Clinical Image Repositories for Real-Word Evaluation of Fatty Liver Disease in People with and without HIV"

October:

• October 5, 2023 - Rebecca Simmons - "The Ying and the Yang of ß-cell Programming"
• October 12, 2023 - Jun Sun - "Microbiome-host interactions in intestinal and extraintestinal cancers"
• October 19, 2023 - Liver Biology Club
• October 26, 2023 - Kandace Gollomp - "TBD"

September:

• September 7, 2023 - Danielle Reed - "The Hyper-personalized Sense of Taste and Smell" (In partnership with the Penn Center for Nutritional Science and Medicine)
• September 14, 2023 - Zhi Ren - "Spatial Structuring of Polymicrobial Oral Biofilms"
• September 21, 2023 - Zay Zhu - "Vibrio cholerae's gut feeling"
• September 28, 2023 - Liver Biology Club

June:

• June 1, 2023 - Louis Cohen - "Mechanisms of Autologous Stem Cell Transplant for the Treatment of Refractory Crohns Disease"
• June 8, 2023 - Semir Beyaz - “Dietary Regulation of Intestinal Regeneration and Cancer”
• June 15, 2023 - Matteo Iannacone - "Immune Surveillance of the Liver"
• June 22, 2023 - Barbara Rehermann - "Wild Mouse Microbiota in Preclinical Models of Inflammation and Metabolism"
• June 29, 2023 - Rebecca Simmons - TBD

May:

• May 18, 2023 - John Chang - "Roles of T Cell Memory in Health and Disease"
• May 25, 2023 - Sammi Wang - “Seq-ing” Insights Into Tissue Injury and Regeneration Using the Mammalian Liver as Model"

April:

• April 13, 2023 - Bryson Katona - "The Role of Menin in Colonic Polyposis and Carcinogenesis"
• April 27, 2023 - Joseph Baur - "Metabolism and Functional Consequences of NAD+ in the Liver"

March:

• March 2, 2023 - Pekka Katajisto - “Stem Cell Niche and the Regenerative Decline of Intestine During Aging”
• March 9, 2023 - Bernd Schnabl - "The Role of Intestinal Fungi in Liver Diseases"
• March 16, 2023 - Laura Su - “Pre-existing T Cell Responses to Intestinal Antigens”
• March 23, 2023 - Nataliya Razumilava - “Mechanisms Regulating Extrahepatic Biled Duct Health and Repair”

February:

• February 9, 2023 - George Hajishengallis - "Inflammatory Epigenetic Memory as a Mechanistic Link in Chronic inflammatory and Metabolic Disease"
• February 16, 2023 - Celeste Simon - "Exploring Tumor Neighborhoods"
• February 23, 2023 - Boris Striepen - "The Biology of the Parasite Cryptosporidium, a Leading Cause Diarrheal Disease in Children"

January:

• January 12, 2023 - Erica Korb - "The Role of Chromatin in Neuronal Function and Disease"
• January 19, 2023 - Esra Shingur - "Targeting Inflammation to Sustain Oral and Systemic Health"
• January 26, 2023 - Garret FitzGerald - "Sex, Age and Time - Perspectives in Chronobiology"

All seminars will be hybrid

December:

• December 22, 2022 - James Lewis - “The Intersection of Food, Microbiome and Metabolites in Health and Inflammatory Bowel Diseases.”
• December 15, 2022 - Utpal Pajvani - "Maladaptive regeneration — Notch at the transition of NASH, fibrosis and HCC"
• December 8, 2022 - David Merrick - TBD
• December 1, 2022 - Harmeert Malhi - TBD

November

• November 17, 2022 - Megan Baldridge - “Interferon-mediated control of viruses in the gut.”
• November 10, 2022 - Zoltan Arany - "Atypical modulation of mTOR to suppress NAFLD/NASH"
• November 3, 2022 - No Seminar, Annual Center Symposia

October:

• October 27, 2022 - Sunny Shin - "Human Inflammasome Responses to Salmonella typhimurium in Myeloid and Intestinal Epithelial Cells"
• October 20, 2022 - Nobuhiro Nakamoto - “ Immunological mechanism of liver fibrosis resolution”
• October 11, 2022 (Tuesday) - Gen-Feng Sheng - "Deciphering the Anti-oncogenic Effects of Oncoproteins in Liver Cancer"
• October 6, 2022 - Mala Maini - "T Cells in Tissue Lockdown"

September:

• September 29, 2022 - Ezra Burstein - "Endosomal protein sorting – adding new pieces to a complex machinery (studies on the CCC and Retriever complexes)" (Hybrid)
• September 15, 2022 - Sean Gibbons - "Community-scale metabolic modeling of the gut microbiome enables the rational design of personalized prebiotic, probiotic, and dietary interventions" (Hybrid)
• September 8, 2022 - Straun Grant - "Variant-to-Gene Mapping for Common Complex Traits" (Hybrid)

June:

• June 23, 2022 - Kari Nejak-Bowen, MBA, PhD - "Therapeutic Implications of Enhancing Beta-Catenin Activation in Hepatocyte Reprogramming"
• June 9, 2022 - Stephanie Watowich, PhD - “Intestinal Toxicity to CTLA-4 Blockade Driven by IL-6 and Myeloid Infiltration”

May:

• May 26, 2022 - Jonathan P. Katz, MD - "Cytoprotective Mechanisms in Esophageal Epithelia"

• May 19, 2022 - Sharon DeMorrow, PhD, FAASLD - "The DNA Damage Response and Cellular Senescence in Hepatic Encephalopathy"

April:

• April 28, 2022 - Jatin Roper, MD - “Mechanisms of Obesity-Associated Colorectal Cancer”
• April 21, 2022 - Bokai Zhu, PhD - "Unveiling ‘Musica Universalis’ of the Cell: Central Dogma Riding the 12-hour Tides" 
• April 7, 2022 - Matthew McConnell - "The Role of Platelets in the Pathogenesis of Alcohol-Associated Liver Disease"

March:

• March 17, 2022 - Maayan Levy, PhD - " Metabotherapy for Intestinal Disease"

• March 10, 2022 - Christopher V. Almario, MD, MSHPM - "Enhancing Shared Decision Making in Gastroenterology Using Digital Tools"

February:

• February 24, 2022 - Ergün Sahin, MD, PhD - "Impact of short telomeres on intestinal differentiation and function"
• February 10, 2022 - Igor Brodsky - "Yersinia pseudotuberculosis infection as a model for study of intestinal granulomas”

January:

• January 27, 2022 - Nicole Maloney Belle - "Intestinal repair proteins: friend, foe or target?"
• January 20, 2022 - Kenneth Cadwell - "Host-microbe symbiosis in the gut"
• January 13, 2022 - Kenneth Zaret - "Modulating Heterochromatin to Elicit Hepatic Cell Fates"
• January 6, 2022 - Purna Kashyap - "Integrative Omics to Mechanisms- Decoding Disorders of the Gut Brain Axis"

December:

• December 9, 2021 - Janelle Corrinne Arthur, PhD - "Gut microbiome and inflammation –associated disease”
• December 2, 2021 - Christopher J. Lengner, BS, PhD - "Patient induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies”

November

• November 18, 2021 - Andrew S. Neish, MD - "Microbiota effects on GI physiology and metabolism"

• November 11, 2021 - Karen Piper Hanley, PhD - “Integrating single-cell and spatial transcriptomics defines altered cell states in human liver fibrosis”

• November 4, 2021 - Ellen Puré, PhD - "Implications of Spatiotemporal Heterogeneity of Stromal Cells and Matrix Remodeling for Pancreatic Cancer Progression and Therapy"

October

• October 28, 2021 - Markus Grompe, MD - "Hepatocyte Ploidy Dynamics in Liver Regeneration and Cancer"
• October 21 - 2021 - Pierre-Emanuel Rautou, MD, PhD - "Role of Endothelial Cells in Fatty Liver Diseases"
• October 14, 2021 - Tracey Simon, MD, MPH - “Novel HCC Prevention Strategies”
• October 7, 2021 - Emma Andersson - “From DUCT to NEPTUNE: novel technologies to manipulate development and decipher mechanisms of regeneration”

September

• September 30, 2021 - Amiram Ariel, MSc, PhD - “New molecular and cellular effectors in resolving inflammation and fibrosis”

• September 23, 2021 - Marino Zerial - “Mechanisms of hepatocyte polarization and liver tissue morphogenesis”

• September 16, 2021 - Michele T. Pritchard, PhD - "Understanding hyaluronan’s contribution to ethanol-enhanced hepatic stellate cell activation after toxin-induced Liver injury"

June

• June 24, 2021 - Paul Carlson Jr., PhD - “Clostridioides difficile Pathogenesis and Associated Microbiome Based Therapeutics”

• June 17, 2021 - Casey M. Theriot, Ph.D. - "Leveraging Lactobacillus Bile Salt Hydrolases for Rational Design of the Gut Microbiota and Prevention of C. difficile”

• June 10, 2021 - Samuel Asfaha, MD, PhD - “Intestinal stem cells and colorectal cancer”

• June 3, 2021 - Reginald Hill, PhD - "Investigating the Role of the ECM in Exosome-mediated Chemoresistance in Pancreatic Cancer”

May

• May 27, 2021 - Melanie G. Gareau, PhD - “Neonatal dysbiosis disrupts the development of the microbiota-gut-brain axis”

• May 20, 2021 - Silvia Vilarinho, MD, PhD - “Genes, Genomes and Liver Disease”

• May 13, 2021 - Ben Stanger, MD PhD - “Embracing tumor heterogeneity with mouse models of pancreas cancer”

• May 6, 2021 - Suzanne Devkota - “Uncovering a microbial mechanism for creeping fat in Crohn’s disease”

April

• April 29, 2021 - Kaufman Lectureship - Talia Golan, MD - “BRCA-associated Pancreatic Cancer”

• April 22, 2021 - Kristen C. Sadler Edepli, M.M.Sc, PhD - “An epigenetic code regulating liver regeneration”

• April 15, 2021 - Kathryn Hamilton, PhD - "IMP-licatingRNA binding proteins in intestinal regeneration"

• April 8, 2021 - Martin J. Blaser, MD - "Immunologic consequences of perturbing the early-life microbiome”

• April 1, 2021 - Christian Jobin, PhD - "Intestinal Microbiota and Cancer. More than meets the eye”

March

• March 25, 2021 - Elke Ober - “Building an organ: From progenitors to a functional hepato-biliary system”

• March 11, 2021 - Neil Henderson, MRCP, PhD, FRCP - "Using single cell genomics to decode the human hepatic fibrotic niche”

• March 4, 2021 - Hyun (Michel) Koo, DDS, MS, PhD - "Spatial organization of polymicrobial oral communities in disease"

February

• February 25, 2021 - Takanori Takebe, MD, PhD - "Modeling human hepato-biliary development and disease"

• February 18, 2021 - Rebecca G. Wells, MD - “Stress from all sides: the mechanics of liver fibrosis and fatty liver disease”

• February 4, 2021 - Josephine Ni, MD - “Determinants of bacterial biofilm formation at the intestinal mucosal interface and their roles in pathogen exclusion”

January

• January 21, 2021 - Moira Hilscher, MD - “Mechanocrine signaling drives portal hypertension through neutrophil activation.”
• January 14, 2021 - Benjamin Voight, PhD - “Casual inference studies for hepatic traits via Mendelian”

December

• December 10, 2020 - Amanda Muir, MD - "Esophageal epithelial progenitor cells in eosinophilic esophagitis"
• December 3, 2020 - Kyong-Mi Chang, MD - "Visualizing the complex hepatic immune microenvironment in chronic hepatitis B using imaging mass cytometry"

November

• November 19, 2020 - Judith Kelsen, MD - "Very early Onset Inflammatory Bowel Disease: A Model for Personalized Medicine in IBD"
• November 5, 2020 - Kirk J. Wangensteen, MD, PhD - “CRISPR screening in vivo uncovers genes required for liver repopulation and tumorigenesis ”

October

• October 29, 2020 - De’BroskiHerbert, PhD - “Clarifying the controversial role of IL-33 in IBD pathogenesis”
• October 22, 2020 - Jeffrey Morris, PhD - “HepatoScore: new biological blood signature for hepatocellular carcinoma”
• October 15, 2020 - Gary D. Wu, MD - “Lessons learned from studying the impact of diet on the human gut microbiome”
• October 8, 2020 - Marijana Vujkovic, PhD - “Identifying Novel Genetic Loci of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Million Veteran Program”

March

• March 12, 2020 - Vesselin Tomov, MD, PhD - “Immune phenotyping of T cells in IBD”

February

• February 27, 2020 - Patrick Seale, PhD - “Metabolic regulation of progenitor cell fate”
• February 20, 2020 - Alex Hughes, PhD - “Kidney tissue engineering by developmental mimicry”
• February 13, 2020 - Edna Cukierman, PhD - “ONCOGENIC SYNAPSES: Stromal Regulators of Pancreatic Cancer Metabolic Support & Innate Immunosuppression”
• February 6, 2020 - Pranoti Mandrekar, MS, PhD - “Stress’ingthe ProteostasisNetwork in Alcoholic Steathohepatitisand Fibrosis”

January

• January 23, 2020 - Yasuko Iwakiri, PhD - "The Role of Lymphatic Vessels in Liver Disease"
• January 16, 2020 - E. Michael Ostap, PhD - "Unexpected roles for cytoskeletal motors – from force sensing, to anchoring, to chirality"

December

• December 19, 2019 - Melike Lakadamyali, PhD - “Super-resolution imaging chromatin organization and dynamics”
• December 12, 2019 - Jerrold R. Turner, MD, PhD - “Tight Junction Channelopathy: A New Class of Mucosal Disease”
• December 5, 2019 - Sydney Shaffer, MD, PhD - “Single-cell plasticity and drug resistance in cancer”

November

• November 21, 2019 - Joseph P. Zackular, PhD - “Mapping pathogen-microbiota interactions during Clostridium difficile infection”
• November 14, 2019 - Michele A. Battle, PhD - “Novel Roles for GATA Factors in the Gastrointestinal Tract Homeostasis and Disease”

October

• October 31, 2019 - Garret A. FitzGerald, MD - “Prostaglandins and their inhibitors”
• October 24, 2019 - Matthew R. Hayes, PhD - “Gut-to-brainstem cellular substrates mediating the anorectic effects of GLP-1 receptor agonists”
• October 17, 2019 - Laurie D. DeLeve, MD, PhD - “Hepatic Fibrosis-Failure to Communicate”
• October 10, 2019 - David B. Weiner, PhD - “Advancing Synthetic DNA Technology for Difficult Disease Targets”

September

• September 26, 2019 - Elizabeth M. Lennon, PhD, DVM - “The Mast Cell in Inflammatory Bowel Disease: Friend or Foe?”
• September 19, 2019 - Mark L. Kahn, MD - “The gut microbiome in regulation of cerebrovascular and GI lymphatic function”
• September 5, 2019 - Arianne L. Theiss, PhD - “Mitochondrial dysfunction triggers intestinal inflammation”

May

• May 2, 2019 - Ning Li, MD - “Plasticity of Enteroendocrinecells during regeneration”

April

• April 18, 2019 - Kathleen E. Sullivan, MD, PhD - “Very early onset IBD, ins and outs and ups and downs”
• April 11, 2019 - Roger A. Greenberg, MD, PhD - “BRCA DNA Damage Response Functions”

March

• March 14, 2019 - Gail Hecht, MD - “Lessons from EPEC about Host Epithelial Physiology”
• March 7, 2019 - Golnaz, Vahedi, MSc, PhD - “Genetic predisposition to type 1 diabetes leads to chromatin misfolding”

February

• February 28, 2019 - Karen L. Edelblum, PhD - “Gamma delta intraepithelial lymphocytes and maintenance of intestinal epithelial barrier”
• February 14, 2019 - Josephine Ni, MD - “Determinants of bacterial biofilm formation at the intestinal mucosal interface and their roles in pathogen exclusion”
• February 7, 2019 - Ning Li, MD - “Plasticity of Enteroendocrinecells during regeneration”

January

• January 31, 2019 - Warren S. Pear, MD, PhD - “Tribbles–from Star Trek to immune response”
• January 24, 2019 - Ronald DeMatteo, MD - “Exploiting immune and molecular features of GIST”
• January 17, 2019 - Erica L. Carpenter, MBA, PhD - “Comprehensive liquid biopsy approaches for diagnosis and monitoring of pancreatic cancer”
• January 10, 2019 - Michael C. Abt, PhD - “Immune Microbiota interactions regulate host defense against C. difficile”

December

• December 13, 2018 - Natalie Terry, MD, PhD - “Enteroendocrinelineage, lipid absorption and microbioaldiversity”
• December 6, 2018 - Christoph A. Thaiss, PhD - “Environmental impacts on the host-microbiome interface”

November

• November 29, 2018 - Josephine Ni, MD - “Nitrogen sensing and effects on colonization by E. coli in the intestinal tract”
• November 15, 2018 - Eric S. Witze, PhD - “Regulation of EGFR signaling by protein palmitoylationin cancer”
• November 8, 2018 - J. Kevin Foskett, PhD - “Calcium addiction of cancer cells”
• November 1, 2018 - Ezra Burstein, MD,PhD - “Contributions to the tumor microenvironment in the intestinal tract”

October

• October 25, 2018 - Xiaolu Yang, PhD - “Control of the embryonic stem cell state by metabolism”
• October 18, 2018 - Harry Janssen, MD, PhD - “Can hepatitis B ever be cured? First clinical steps using new compounds and biomarkers”
• October 11, 2018 - Maayan Levy, PhD - “A new player in intestinal epithelial immunity”

September

• September 20, 2018 - M. Andres Blanco, PhD - “The epigenetic basis of myeloid cell fate decisions”
• September 13, 2018 - Tzipora Sarah Karin Eisinger, PhD - “Deregulation of the Hippo pathway resets the clock in sarcoma”
• September 6, 2018 -Laura E. Nagy, PhD - “MicroRNA profiling of hepatic macrophages in models of ALD”

July

• July 12, 2018 -Sahar Nissim, MD, PhD - “Discovery, Validation, and Characterization of a Novel Hereditary Pancreatic Cancer Gene”

May

• May 24, 2018 - Kelly Whelan, PhD - “Mechanisms of esophageal homeostasis: Implications for improving patient outcomes in food allergy and cancer"
• May 10, 2018 - Bryson Katona, MD, PhD - “Uncovering novel roles of menin in colon cancer”
• May 3, 2018 - Andrei Thomas Tikhonenko, PhD - “TGFbeta signaling in colorectal cancer”

April

• April 19, 2018 - Hugo R. Rosen, MD - “What are the remaining immunologic questions in hepatitis C? In Fatty liver disease?”
• April 12, 2018 - Nicholas J. Hand , PhD - “MicroRNAs in liver development and disease”
• April 5, 2018 - Christina Twyman Saint Victor, MD, MTR - “Improving Response to Immune Checkpoint Blockers in Melanoma and Pancreatic Adenocarcinoma”

March

• March 29, 2018 - Marcia Cruz Correa, MD, PhD - “Gastric Cancer: Prevention & Diagnosis”
• March 22, 2018 - Ezra Burstein, MD, PhD - “Epithelial differentiation and immune function in the gastrointestinal mucosa”
• March 8, 2018 - Kathryn E. Wellen, PhD - “Metabolism, epigenetics, and tumorigenesis”
• March 1, 2018 - Ana Gamero, PhD - “The transcription factor STAT2: An unexpected accomplice in colon carcinogenesis”

February

• February 22, 2018 - Seung Kim, MD, PhD - "Intercellular signaling at the nexus of diabetes, chronic pancreatitis and pancreatic cancer: the legacy of our hungry ancestors
• February 15, 2018 - Ravikanth Maddipati, MD - “The origins of metastasis in pancreatic cancer: a colorful tale”
• February 8, 2018 - Kathryn Wellen, PhD - “Metabolism, epigenetics and tumorigenesis”

January

• January 25, 2018 - Boris Striepen, PhD - “Molecular approaches to cryptosporidiosis a leading cause of severe diarrhea and child mortality”
• January 18, 2018 - Michael P. Verzi, PhD - “Epigenomics of Intestinal Development and Disease”
• January 11, 2018 - Eric J. Brown, PhD - “Replication stress responses as cancer treatment targets”
• January 4, 2018 - Karen E. Knudsen, PhD - “Targeting cell cycle dysfunction in advanced prostate cancer”

December

• December 21, 2017 - Klaus H. Kaestner, PhD - “The Intestinal Stem Cell Niche The Final Answer”
• December 14, 2017 - Daniel P. Beiting, PhD - “MicrobiomeDB : a systems biology toolkit for integrating, mining and analyzing public microbiome experiments”
• December 7, 2017 - Andrew D. Patterson, PhD - “Intestinal Epithelial Cell Receptors as Moderators of Host Microbiota Communication”

November

• November 16, 2017 - Zachary Schug, PhD - “Acetate metabolism in cancer”
• November 2, 2017 - Ronen Marmorstein, PhD - “Structure-based development of BRAF kinase dimer inhibitors”

October

• October 26, 2017 - Ulrich Beuers, MD, PhD - “The biliary bicarbonate umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies”
• October 19, 2017 - Michael Lampson, PhD - “Optogenetic control of cell biology: insights into mitotic chromosome segregation”
• October 12, 2017 - Gregory Gores, MD - “Inflammatory Extracellular Vesicles in NASH Pathogenesis”
• October 5, 2017 - Bruce L. Levine, PhD - “Chimeric Antigen Receptor (CAR)T Cells for Malignancy: Development of a First In Class Therapy”

September

• September 28, 2017 - Clara Abraham, MD - “Innate Immune Dysregulation in Inflammatory Bowel Disease”
• September 21, 2017 - Yana Kamberov, PhD - “A conserved genetic circuit in skin and neural development and its role in human evolution”
• September 7, 2017 - Averil Ma, MD - “The Ubiquitous Nature of Human Disease ”

June

• June 8, 2017 - Sandra W. Ryeom, PhD - “Oncogenic KRAS and p53 loss drive gastric tumorigenesis in a new mouse model of gastric cancer and can be attenuated by E-cadherin expression”
• June 1, 2017 - Ellen Puré, PhD - “Honing in on stroma-dependent mechanisms that promote tumorigenesis and metastasis”

May

• May 25, 2017 - Premal Shah, B. Tech, PhD - “Dynamics and evolution of translational regulation”

April

• April 27, 2017 - Richard K. Assoian, PhD - “Sensing and remodeling ECM and tissue stiffness”
• April 13, 2017 - M. Celeste Simon, PhD - “Hypoxic Influences on Cancers of the Pancreas and Kidney”
• April 6, 2017 - Peter Klein, MD, PhD - “Interplay between Wnt and mTOR signaling in somatic stem cell homeostasis”

March

• March 30, 2017 - Hao Wu, PhD - “Charting DNA (de)methylome in mammalian stem cells and development”
• March 23, 2017 - Andy Minn, MD, PhD - “Opposing Roles of Interferon Signaling in Regulating Response to Cancer Immune Checkpoint Blockade”
• March 9, 2017 - Alessio Fasano, MD - “Nutrition, microbiome, gut permeability, and pathogenesis of chronic inflammatory diseases: the Celiac disease paradigm”
• March 2, 2017 - David E. Cohen, MD, PhD - “Hepatic Fatty Acid Channeling as a Target in the Management of Non-Alcoholic Fatty Liver Disease”

February

• February 27, 2017 - Kirk Wangensteen, MD, PhD - “Novel Genetic Approaches to Elucidate the Mechanisms of Liver Regeneration and Cancer”
• February 23, 2017 - Guillermina Lozano, PhD - “p53 function and dysfunction”
• February 16, 2017 - Rajan Jain, MD - “Mechanisms establishing and maintaining cellular identity”
• February 9, 2017 - Gloria Su, PhD - “Lessons learned from mouse modeling for human pancreatic cancer”
• February 2, 2017 - Raymond Soccio, MD, PhD - “PPARs: Regulatory Genetic Variation and Fatty Liver Disease”

January

• January 26, 2017 - Maureen Murphy, PhD - “An African-specific variant of the p53 tumor suppressor gene predisposes to liver and other cancers”
• January 19, 2017 - MickolasPapadopoulos, PhD - “Harnessing the Information from Cancer Genomes: From Genomic Landscapes to Liquid Biopsies”
• January 12, 2017 - Paul Gadue, PhD - “Using human pluripotent stem cells to model monogenic forms of diabetes”
• January 5, 2017 - Kojo Elenitoba-Johnson, MD - “Mass spectrometry as a driver of discovery in MALT lymphoma pathogenesis”

December

• December 22, 2016 - Constantinos Koumenis, PhD - “A novel mouse model to study image-guided, radiation-induced intestinal injury and preclinical screening of radioprotectors”
• December 15, 2016 - Wei Guo, PhD - “Exosomes in Tumorigenesis and Immunosuppression”
• December 8, 2016 - Montserrat Anguera, PhD, BA - “Unusual maintenance of X-chromosome Inactivation in female lymphocytes: a novel parameter for understanding female-biased autoimmune disorders”
• December 1, 2016 - Jay Horton, MD - “Molecular Mediators of Lipogenesis in NAFLD”

November

• November 17, 2016 - Michael P. Verzi, PhD - “Epigenomics of Intestinal Development and Disease”
• November 10, 2016 - Jeffrey D. Winkler, PhD - “Synthesis of Natural and Unnatural Products”
• November 3, 2016 - Pantelis Rompolas, PhD - “Mechanisms of cell fate in epidermal maintenance, regeneration and tumorigenesis”

October

• October 20, 2016 - Junwei Shi, PhD - “Liver cancer target identification using functional genetic approaches”
• October 13, 2016 - Konstantinos Drosatos, MSc, PhD - “Kruppel-like factor 5:How a cardiomyocyte protein regulates systemic metabolism”
• October 6, 2016 - De’Broski R. Herbert, PhD - “Trefoil Factor Family Proteins Promote Lung Regeneration and Type 2 Responses”

September

• September 15, 2016 - Phong Tran, PhD - “New aspects of cell polarity and cell division”
• September 8, 2016 - Patrick Viatour, MSc, PhD - “Liver Cancer: A Tale of Two Ends”

June

• June 23, 2016 - Xiao Zhao, MD - “The role of redox signaling in toxin—induced biliary atresia”
• June 9, 2016 - Bryson Katona, MD, PhD - “Menin in colon cancer: An unexpected journey”
• June 2, 2016 - David Shen, MD - The Role of Gut Microbiota Urease in Mammalian Host Nitrogen Metabolism”

May

• May 5, 2016 - Qihong Huang, MD, PhD - Significance of RNA editing in tumor metastasis”

April

• April 28, 2016 - Xianxin Hua, MD, PhD - “CAR T project on neuroendocrine tumor”
• April 21, 2016 - Richard Gregory, PhD - “RNA Regulation in Stem Cells and Disease”
• April 14, 2016 - Scott Magness, PhD - “Intestinal Stem Cells: Drivers of innovative high-throughput organoid analysis and biomimetic gut cultures”