Conference Proceedings

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Friday, November 11, 2022

7:00 am - 6:00 pm EST

In Person at

The Rittenhouse Hotel

210 W Rittenhouse Square

Philadelphia, PA 19103

or

Virtually via AJI Media Livecast powered by Accelevents

7:00 am

Check In

In Person: Check in, Visit Exhibits and Continental Breakfast
Virtual: Login to Virtual Conference - Visit Virtual Exhibit Hall
7:30 am

Welcome and Introductions

Sunil Singhal, MD // Thoracic Surgery // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
John Y.K. Lee, MD, MSCE  // Neurosurgery // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
Edward J. (Jim) Delikatny, PhD  // Radiology/Optical Bioluminescence // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
Robert H. Vonderheide, MD, DPhil // Abramson Cancer Center // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
Daniel Yoshor, MD // Neurosurgery // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
D. Gregory Farwell, MD, FACS // Otorhinolaryngology – Head and Neck Surgery // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine

SESSION 1    CLINICALLY APPROVED AND PHASE III TRIALS

 Moderators:  Eric R. Henderson, MD  // Adult and Pediatric Orthopedics // Geisel School of Medicine, Dartmouth / Dartmouth Health
David E. Holt, BVSc // Surgery // University of Pennsylvania School of Veterinary Medicine

7:45 am

5-ALA in EUROPE – FUTURE STEPS

Walter Stummer, MD, PhD  // Neurosurgery // Münster University Hospital
8:00 am

PAFOLACIANINE for Ovarian Cancer

Janos L. Tanyi, MD, PhD // Gynecologic Oncology // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
8:15 am

PAFOLACIANINE for Lung Cancer: Phase 3 US Trial

Linda W. Martin, MD, MPH // Thoracic Surgery // University of Virginia School of Medicine
8:35 am

CEA Colon Cancer Trial: Phase 3 European Trial

Alexander L. Vahrmeijer, MD // Oncologic Surgery // Leiden University Medical Center
8:55 am

Protease Activated Dye in Breast Cancer Surgery: Phase 3 US Trial

Barbara L. Smith, MD, PhD // Breast Surgery // Harvard Medical School / Massachusetts General Hospital
9:15 am

Q&A Panel Discussion

9:25 am

Break and Visit Exhibits

SESSION 2 PHASE II CLINICAL TRIALS

Moderator:  Karthik Rajasekaran, MD, FACS // Head and Neck Oncologic & Microvascular Reconstructive Surgery // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
9:45 am

Anti-EGFR Antibody Imaging Strategies for Real-Time Surgical and Pathologic Guidance

Eben Rosenthal, MD // Otolaryngology - Head & Neck Surgery // Vanderbilt University Medical Center
10:05 am

Phase II Trial of Intraoperative Molecular Imaging of Lung Cancer with Cathepsin Imaging

Sunil Singhal, MD  // Thoracic Surgery // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
10:25 am

pH Sensitive Dyes in Peritoneal Surface Malignancy

Patrick Wagner, MD, FACS // Surgical Oncology // Allegheny Health Network (AHN) Cancer Institute
10:45 am

pH Sensitive Dyes in Phase II Lung Cancer Trial

David C. Rice, MB, BCh, FRCSI // Thoracic Surgery // M.D. Anderson Cancer Center // Houston, Texas
11:05 am

Q&A Panel Discussion

SESSION 3: PEDIATRIC HOUR

Moderators: Tracy Ma Flanders, MD, MSCE // Pediatric Neurosurgery // Children's Hospital of Philadelphia 

Andrew M. Davidoff, MD // Pediatric Surgery // St. Jude Children's Research Hospital

11:15 am

Tumor Paint™ Imaging – Pediatric Brain Tumors – PHASE TWO

Amy Lee, MD // Pediatric Neurosurgery // University of Washington / Seattle Children’s Hospital
11:30 am

Clinical Experience Using ICG

Abdelhafeez H. Abdelhafeez, MD // Pediatric Surgery // St. Jude Children's Research Hospital
11:45 am

Pre-Clinical Experience on Targeted Agents for Pediatric Solid Tumors

Marcus M. Malek, MD, FAAP // Pediatric Surgical Oncology // University of Pittsburgh / UPMC
12:00 pm

Q&A Panel Discussion

12:10 pm

Lunch and Visit Exhibits

Session 4: PILOT AND PHASE I CLINICAL TRIALS

Moderator: Andrew Tsourkas, PhD  //  Bioengineering //|  Perelman School of Medicine at the University of Pennsylvania / Penn Medicine

12:55 pm

EGFR Affibody: Design & Implementation of Novel Targeted Tumor Dye

Eric R. Henderson, MD  //  Adult and Pediatric Orthopedics  //  Geisel School of Medicine, Dartmouth / Dartmouth Health
1:10 pm

uPAR-targeting Dye (Fluoguide) for Surgery of Gliomas

Jane Skjoth-Rasmussen, MD, PhD // Adult and Pediatric Neurosurgery // Rigshospitalet / Copenhagen University Hospital / University of Copenhagen
1:25 pm

TumorGlow™ Second Window ICG in Brain Tumors

 
John Y.K. Lee MD, MSCE // Neurosurgery // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
1:40 pm

Q&A Panel Discussion

SESSION 5: NORMAL TISSUE DYES

Moderators: E. James Petersson, PhD // Chemistry // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
Sofya A. Osharovich, PhD // Pharmacology // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
1:50 pm

Nerve Specific Dyes – Normal Tissue Identification

Ryan K. Orosco, MD // Otolaryngology // University of New Mexico
2:05 pm

Near Infrared Nerve-Specific Probes for Intraoperative Nerve Visualization

Summer L. Gibbs, PhD // Biomedical Engineering // Oregon Health & Science University (OSHU) School of Medicine / OSHU Knight Cancer Institute
2:20 pm

Ureter Dyes During Urologic Cancer Surgery – Normal Tissue Identification

Richard W. Farnam, MD // Gynecology // Las Palmas Del Sol Healthcare
2:35 pm

Q&A Panel Discussion

Session 6: HOW TO GET FROM BENCH TO BEDSIDE

Moderator:  Mark Anthony Sellmyer, MD, PhD // Radiology // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine

2:45 pm

Choline Kinase Dyes

Edward J. (Jim) Delikatny, PhD // Radiology / Optical Bioluminescence // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
3:00 pm

NIH Perspective of Clinical Trials in Intraoperative Molecular Imaging

Lalitha K. Shankar, MD, PhD // Cancer Imaging Clinical Trials Branch // National Cancer Institute / Division of Cancer Treatment and Diagnosis
3:15 pm

Q&A Panel Discussion      

SESSION 7: ALTERNATIVE IMAGING STRATEGIES

Moderator: Wesley B. Baker, PhD // Pediatric Neurology / Biomedical Optical Devices // Children’s Hospital of Philadelphia
3:25 pm

Fluorescence Lifetime Imaging with Dyes

Anand Kumar, PhD // Radiology / Optical Molecular Imaging // Harvard Medical School / Massachusetts General Hospital
3:40 pm

Label–Free Fluorescence Lifetime Imaging

Laura Marcu, PhD // Biomedical Engineering / Neurological Surgery // University of California
3:55 pm

Photoacoustic Imaging

Lei Li, PhD // Medical Engineering // California Institute of Technology / Caltech
4:10 pm

MultiSpectral Camera Imaging

Viktor Gruev, PhD // Electrical and Computer Engineering // University of Illinois at Urbana-Champaign   
4:25 pm

Q&A Panel Discussion                      

4:35 pm

PANEL DISCUSSION – FUTURE UNMET NEEDS (all speakers)

Moderator: Sunil Singhal, MD  // Thoracic Surgery // Perelman School of Medicine at the University of Pennsylvania / Penn Medicine
5:00 pm

CME Concludes

5:05 pm

Refreshments | Break | Visit Exhibits

5:35 pm

pH Sensitive Dyes

Baran Sumer, MD // Otorhinolaryngology // University of Texas / UT Southwestern Medical Center
6:00 pm

Conference Concludes