Mark Anthony Sellmyer, MD, PhD

faculty photo
Assistant Professor of Radiology
Active, Pennsylvania Hospital – Dept. of Radiology, Division of Nuclear Medicine
Active, Penn Presbyterian Medical Center – Dept. of Radiology, Division of Nuclear Medicine
Active, Chester County Hospital – Dept. of Radiology
Attending, Hospital of the University of Pennsylvania – Dept. of Radiology, Division of Nuclear Medicine
member, Chemistry and Biology Interfaces Program
member, Abramson Cancer Center
member, Institute for Translational Medicine and Therapeutics
Co-director, Center for Translational Chemical Biology, University of Pennsylvania
Director, UPenn, Small Animal Imaging Facility, NMI sub-core
member, UPenn, PET Center Executive Committee
Department: Radiology

Contact information
University of Pennsylvania
Perelman School of Medicine
Department of Radiology
3400 Spruce St., 1 Silverstein, Ste. 130
Philadelphia, PA 19104
Office: 617-543-6546
Lab: 215-573-3212
BS (Chemistry)
Massachusetts Institute of Technology , 2004.
PhD (Chemical and Systems Biology)
Stanford Medical School, 2012.
Stanford Medical School, 2012.
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Description of Clinical Expertise

Nuclear Radiology
Cancer Imaging and Therapy
Infection and Inflammation

Description of Research Expertise

Molecular Imaging
Chemical Biology
Synthetic Biology
Nuclear Imaging and Therapy

Selected Publications

Sellmyer Mark A, Richman Sarah A, Lohith Katheryn, Hou Catherine, Weng Chi-Chang, Mach Robert H, O'Connor Roddy S, Milone Michael C, Farwell Michael D: Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene. Molecular therapy : the journal of the American Society of Gene Therapy 28(1): 42-51, Jan 2020.

Alvaro A. Ordonez, Mark A. Sellmyer, Gayatri Gowrishankar, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Christopher J. Palestro, Dima A. Hammoud1, Sanjay K. Jain*: Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation. Science Translational Medicine. AAAS, Vol. 11, (Issue 508), Sept 2019.

Sellmyer, M. A. Iljung Leea, Catherine Houa, Chi-Chang Wenga, Shihong Lia, Brian P. Liebermana, Chenbo Zenga, David A. Mankoff , Robert H. Mach : Bacterial infection imaging with [18F]fluoropropyl-trimethoprim. PNAS 114(31): 8372-8377, Aug 2017.

Makvandi, M., Sellmyer, M. A. & Mach, R. H.: Inflammation and DNA damage: Probing pathways to cancer and neurodegeneration. Drug Discov Today Technol 25: 37-43, Nov 2017.

Sellmyer, M.A., Lee, I., Hou, C., Lieberman, B.P., Zeng, C., Mankoff, D.A., Mach, R.H.: Quantitative PET reporter gene imaging with [11C]trimethoprim. Molecular Therapy 25(1): 120-126, Jan 2017.

Jones, J., Li, D., Hui, E,. Sellmyer, M.A., Prescher, J.A.: Visualizing cell proximity with genetically encoded bioluminescent reporters. ACS Chemical Biology 10(4): 933-8, Apr 2015.

Sellmyer, M.A., Bronsart, L., Imoto, H., Contag, C.H., Wandless T.J., Prescher, J.A.: Visualizing Cellular Interactions with a Generalized Proximity Reporter. The Proceedings of the National Academy of the Sciences 21(110): 8567-8572, May 2013.

Sellmyer, M. A., Desser, T. S., Maturen, K. E., Jeffrey, R. B., Kamaya, A.: Physiologic, Histologic, and Imaging Features of Retained Products of Conception. Radiographics 33(3): 781-796, May 2013.

Kwan, M.D., Sellmyer, M.A., Quarto, N., Ho, A.M., Wandless, T.J., Longaker, M.T. : Chemical control of FGF-2 release for promoting calvarial healing with adipose stem cells. J. Biol. Chem. 286(13): 11307-11313, Apr 2011.

Banaszynski, L. A., Sellmyer, M. A., Contag, C. H., Wandless, T. J., Thorne, S. H.: Chemical control of protein stability and function in living animals. Nature Medicine 14(10): 1123-1127, Oct 2008.

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Last updated: 12/06/2023
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