Faculty

Daria V Babushok, MD, PhD

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Biomedical Research Building II/III, Room 808
421 Curie Boulevard
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215-614-1847
Fax: 215-615-5888
Lab: 215-573-0667
Education:
BA (Biology, Chemistry)
Bryn Mawr College, 2000.
PhD (Cellular and Molecular Biology)
University of Pennsylvania, 2007.
MD (Medicine)
University of Pennsylvania, 2008.
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Description of Clinical Expertise

Bone marrow failure syndromes (inherited and acquired), acquired aplastic anemia, paroxysmal nocturnall hemoglobinuria, clonal hematopoiesis, MDS/AML predisposition syndromes, MPN predisposition syndromes, myeloproliferative neoplasms

Description of Research Expertise

RESEARCH INTERESTS:
The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.

We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the development of clonal hematopoiesis in bone marrow failure and aging.

KEYWORDS:
Clonal hematopoiesis, bone marrow failure, aplastic anemia, PNH, malignant predisposition to MDS and leukemia

ROTATION PROJECTS:
We are always looking for talented individuals who are passionate about science. There are opportunities to contribute at every level, and we welcome inquiries from undergraduate and graduate students, postdoctoral scientists, and medical students, residents, and fellows. Please contact Daria.Babushok at uphs.upenn.edu to discuss research opportunities.

SEE BABUSHOK LAB WEBSITE

LAB MEMBERS:
Kathy Guo – Research Specialist
Caitlin Ritz - Research Specialist
Natasha Stanley – Research Specialist

MEDICAL STUDENT RESEARCHERS:
Taylor Linaburg – Medical Student
Tristan Lim - Medical Student

UNDERGRADUATE RESEARCHERS:
Ben Frost
Jahnvi Patel

Selected Publications

Graveno ME, Carulli A, Freyer CW, Mangan BL, Nietupski R, Loren AW, Frey NV, Porter DL, Gill SI, Hexner EO, Luger SM, Martin ME, McCurdy SR, Perl AE, Babushok DV, Pratz KW. : Venetoclax in combination with hypomethylating agents or low dose cytarabine for relapsed and refractory acute myeloid leukemia. Leuk Lymphoma March 2022.

Ghosh S, Roth J, Babushok D, Lim M. : Significance of RUNX1 mutation in BCR-ABL1 positive acute myeloid leukemia - a diagnostic dilemma in a young woman with persistent bleeding. Leuk Lymphoma. March 2022.

Freyer CW, Carulli A, Gier S, Ganetsky A, Timlin C, Schuster M, Babushok D, Frey NV, Gill SI, Hexner EO, Luger SM, Mangan JK, Martin ME, McCurdy SR, Perl AE, Porter DL, Pratz K, Smith J, Stadtmauer EA, Loren AW.: Letermovir vs. high-dose valacyclovir for cytomegalovirus prophylaxis following haploidentical or mismatched unrelated donor allogeneic hematopoietic cell transplantation receiving post-transplant cyclophosphamide. Leuk Lymphoma Feb 2022.

Hatch RV, Freyer CW, Carulli A, Redline G, Babushok DV, Frey NV, Gill SI, Hexner EO, Luger SM, Martin ME, McCurdy SR, Perl AE, Porter DL, Pratz KW, Stadtmauer EA, Loren AW. : Day 4 vs. day 12 G-CSF administration following reduced intensity peripheral blood allogeneic stem cell transplant. J Oncol Pharm Pract Feb 2022.

Colden M, Kumar S, Munkhbileg B, Babushok DV: Insights into the emergence of paroxysmal nocturnal hemoglobinuria. Front Immunol. Jan 2022.

Zha J, Kunselman LK, Xie HM, Ennis B, Shah YB, Qin X, Fan JM, Babushok DV, Olson TS.: Inducible Sbds Deletion Impairs Bone Marrow Niche Capacity to Engraft Donor Bone Marrow After Transplantation. Blood Adv. Oct 2021.

Kumar S, Babushok DV. : Analysis of evolutionary conservation of GPI-anchored proteins between humans and mice. Blood Cells Molecules Diseases Oct 2021.

Lim TL, Lieberman DB, Davis AR, Loren AW, Hausler R, Bigdeli A, Li Y, Powers J, Raper A, Regeneron Genetics Center, Carty SA, Nathanson KL, Bagg A, Hexner EO, Maxwell KN, Morrissette JJD, Babushok DV. : Germline POT1 variants can predispose to myeloid and lymphoid neoplasms. Leukemia. June 2021.

Freyer CW, Gier S, Moyer ME, Berryman N, Carulli A, Ganetsky A, Timlin C, Babushok DV, Frey NV, Gill SI, Hexner EO, Loren AW, Mangan JK, Martin ME, McCurdy S, Perl AE, Smith J, Luger SM, Stadtmauer EA, Porter DL.: Leucovorin Rescue After Methotrexate Graft-Versus-Host Disease Prophylaxis Shortens the Duration of Mucositis, Time to Neutrophil Engraftment, and Hospital Length of Stay. Transplant Cell Ther. 27(5), May 2021.

Freyer CW, Carulli A, Gier SH, Ganetsky A, Timlin C, Schuster MJ, Babushok DV, Frey NV, Gill SI, Hexner EO, Mangan JK, Martin ME, McCurdy SR, Perl AE, Pratz KW, Smith J, Luger SM, Stadtmauer EA, Porter DL and Loren AW. : Letermovir Vs High Dose Valacyclovir for Cytomegalovirus Prophylaxis Following Haploidentical Allogeneic Hematopoietic Transplantation. Presentation submitted to 2021 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR. 2021.

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Last updated: 05/17/2022
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