Biomedical Graduate Studies

Description of Clinical Expertise

Bone marrow failure syndromes (inherited and acquired), acquired aplastic anemia, paroxysmal nocturnal hemoglobinuria, telomere biology disorders, clonal hematopoiesis, MDS/AML predisposition syndromes, MPN predisposition syndromes, myeloproliferative neoplasms

Description of Research Expertise

RESEARCH INTERESTS:
The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms by which bone marrow can fail, how bone marrow failure can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and the relationship between our immune system and bone marrow failure and clonal hematopoiesis.

We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the development of clonal hematopoiesis in bone marrow failure and aging.

KEYWORDS:
Clonal hematopoiesis, bone marrow failure, aplastic anemia, PNH, telomere biology disorders, germline predisposition, myelodysplastic syndrome (MDS) and leukemia

ROTATION PROJECTS:
We are always looking for talented individuals who are passionate about science. There are opportunities to contribute at every level, and we welcome inquiries from undergraduate and graduate students, postdoctoral scientists, and medical students, residents, and fellows. Please contact Daria.Babushok at uphs.upenn.edu to discuss research opportunities.

SEE BABUSHOK LAB WEBSITE

POSTDOCTORAL FELLOWS:
Bolormaa Munkhbileg, MD MS – Postdoctoral Fellow
Deepanshu Maheshwari, PhD – Postdoctoral Fellow

HEMATOLOGY-ONCOLOGY FELLOWS:
Gabriel Aleixo, MD – Hematology-Oncology Fellow
Aaron Cheng, MD – Hematology-Oncology Fellow
Lukas Ronner, MD, MS – Hematology-Oncology Fellow

GRADUATE STUDENTS:
Yiwei Wang, MS - IGG rotation student

MEDICAL STUDENT RESEARCHERS:
Aura Enache – Medical Student
Andrew Hu - Medical Student
Sagar Gupta - MD/PhD Student

POSTBACCALAUREATE RESEARCHERS:
Alex Howe – Postbaccalaureate Researcher
Shannon Zheng – Postbaccalaureate Researcher