Home » Imaging-based Research » Janis K. Burkhardt
Imaging-based Research
Janis K. Burkhardt, Ph.D.
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
Department of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
Perelman School of Medicine University of Pennsylvania
816B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104
Children's Hospital of Philadelphia
Perelman School of Medicine University of Pennsylvania
816B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: (267) 426-5410
Fax: (267) 426-5165
Lab: (267) 426-5523
Fax: (267) 426-5165
Lab: (267) 426-5523
Publications
Education:
A.B. (Biology, Magna Cum Laude)
Washington University, 1983.
Ph.D. (Microbiology and Immunology)
Duke University, 1989.
Permanent linkA.B. (Biology, Magna Cum Laude)
Washington University, 1983.
Ph.D. (Microbiology and Immunology)
Duke University, 1989.
Selected Publications
Shaffer MH, Dupree RS, Zhu P, Saotome I, Schmidt RF, McClatchey AI, Freedman BD, Burkhardt JK.: Ezrin and moesin function together to promote T cell activation. J Immunol 182(2): 1021-1032. Jan 2009 PMCID: PMC3491660.Huang Y, Comiskey EO, Dupree RS, Li S, Koleske AJ, Burkhardt JK.: The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood 112(1): 111-119. Jul 2008 PMCID: PMC2435682.
Burkhardt, J.K., Carrizosa, E. and Shaffer, M.H.: The actin cytoskeleton in T cell activation. Ann Rev Immunol 26, 233-259, Nov 2008.
Nolz JC, Gomez TS, Zhu P, Li S, Medeiros RB, Shimizu Y, Burkhardt, JK, Freeman BD, Billadeau, DD. : WAVE2 regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Current Biology 16(1): 24-34, Jan 2006.
Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt, JK. : HS1 functions as an essential actin-regulatory adapter protein at the immune synapse. Immunity 24(6): 741-752, Jun 2006.
Gomez TS., Hamann MJ., McCarney S., Savoy DN., Lubking CM., Heldebrant MP., Labno CM., McKean DJ., McNiven MA., Burkhardt JK., Billadeau DD.: Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nature Immunology 6(3): 261-270, Mar 2005.
Labno CM., Lewis CM., You D., Leung DW., Takesono A., Kamberos N., Seth A., Finkelstein LD., Rosen MK., Schwartzberg PL., Burkhardt JK.: Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Current Biology 13(18): 1619-1624, Sept 2003.
Allenspach EJ, Cullinan P, Tong J, Tang Q, Tesciuba AG, Cannon JL, Takahashi SM, Morgan R, Burkhardt JK, Sperling AI.: ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15(5): 739-750, Nov 2001.
Cannon JL, Labno CM, Bosco G, Seth A, McGavin MH, Siminovitch KA, Rosen MK, Burkhardt JK.: Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation. Immunity 15(2): 249-259, Aug 2001.
Billadeau, D.D. and Burkhardt, J.K.: Regulation of Cytoskeletal Dynamics at the Immune Synapse: New Stars Join the Actin Troupe. Traffic 7(11): 1451-1460. Nov 2006.