Golnaz Vahedi

faculty photo
Associate Professor of Genetics
Member, Institute For Immunology and Immune Health, Penn Medicine
Core member, Penn Epigenetics Institute, Penn Medicine
Member, Institute for Diabetes, Obesity and Metabolism Institute, Penn Medicine
Member, Abramson Cancer Center, Penn Medicine
Deputy Director of Innovation and Technology, Institute for Immunology & Immune Health, Penn Medicine
Co-Director, Penn Epigenetics Institute, Penn Medicine
Department: Genetics

Contact information
421 Curie Boulevard
Philadelphia, PA 19104
B.Sc. (Electrical Engineering)
Sharif University of Technology, Iran, 2001.
M.Sc. (Electrical Engineering)
University of Alberta, Canada, 2005.
Ph.D. (Electrical Engineering)
Texas A&M University, Texas, 2009.
Permanent link
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Description of Research Expertise

The overarching goal of the Vahedi laboratory is to understand the molecular mechanisms through which genomic information in our immune cells is interpreted in normal development and further dissect how common genetic variation can lead to misinterpretation of the genetic material in immune mediated diseases. The multidisciplinary nature of our laboratory allows us to exploit cutting-edge computational and experimental approaches and generate unbiased maps of genome organization in primary immune cells in humans and mice. We further follow our hypothesis-generating yet unbiased efforts with experiments dissecting the mechanisms of our predictions using genome editing in mice or cell lines which provides us with an unparalleled opportunity to rigorously define the link between genetics and chromatin organization.

Selected Publications

Patil, A.R., Schug, J., Liu, C., Lahori, D., Descamps, H.C., the Human Pancreas Analysis Consortium, Naji, A., Kaestner, K.H., Faryabi, R.B., Vahedi, G.: Modeling Type 1 Diabetes progression from single-cell transcriptomic measurements in human islets. Cell Reports Medicine May 2024.

Goldman N, Chandra A, Johnson I, Sullivan MA, Patil AR, Vanderbeck A, Jay A, Zhou Y, Ferrari EK, Mayne L, Aguilan J, Xue HH, Faryabi RB, Wherry EJ, Sidoli S, Maillard I and Vahedi G. : Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity. Nature Immunology 24(9), August 2023.

Chandra# A., Yoon# S., Michieletto# M.F., Goldman N., Ferrari E.K., Abedi M., Johnson I., Fasolino M., Pham K., Joannas L., Kee B.L., Henao-Mejia* J, and Vahedi* G. #co-first authors *co-corresponding authors: Quantitative control of Ets1 dosage through a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation. Immunity 58, July 2023.

Michieletto# MF, Tello-Cajiao# JJ, Mowel WK, Chandra A, Yoon S, Joannas L, Clark ML, Jimenez MT, Wright JM, Lundgren P, Williams A, Thaiss CA, Vahedi* G, Henao-Mejia* J., #co-first authors *co-corresponding authors: Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation. Nature Immunology 1, January 2023.

Wang# W, Chandra# A, Goldman# N, Yoon# S, Ferrari# EK, Nguyen SC, Joyce EF, Vahedi G. #co-first authors: TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors. Nature Immunology 23(7), July 2022.

Yoon, S., Chandra, A. and Vahedi, G.: Stripenn detects architectural stripes from chromatin conformation data using computer vision. Nature Communications 13(1602), March 2022.

Fasolino M, Schwartz GW, Patil AR, Mongia A, Golson ML, Wang YJ, Morgan A, Liu C, Schug J, Liu J, Wu M, Traum D, Kondo A, May CL, Goldman N, Wang W, Feldman M, Moore JH, Japp AS, Betts MR; HPAP Consortium, Faryabi RB, Naji A, Kaestner KH, Vahedi G.: Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in Type 1 Diabetes. Nature Metabolism 4(2), February 2022.

Fasolino M., Goldman N., Wang W., Cattau B., Zhou Y., Petrovic J., Link V.M., Cote A., Chandra A., Silverman M., Joyce E.F., Little S.C., the HPAP Consortium, Kaestner K.H., Naji A., Raj A., Henao-Mejia J., Faryabi R.B., and Vahedi G.: Genetic Variation in Type 1 Diabetes Reconfigure the 3D Chromatin Organization of T Cells. Immunity. Cell Press, 52(2): 257-274, February 2020 Notes: Featured on journal's cover. Highlighted on Spotlight in Trends Immunology.

Wang W., Fasolino M., Cattau B., Goldman N., Kong W., Frederick M., McCright S., Kiani K., Fraietta J.A., Vahedi G.: Joint Profiling of Chromatin Accessibility and CAR-T Integration Site Analysis at Population and Single-cell Levels. Proceedings of National Academy of Sciences 117(10): 5442-5452, March 2020.

Johnson J.L., Georgakilas G., Petrovic J., Kurachi M., Cai S., Harly C., Pear W.S., Bhandoola A., Wherry E.J., Vahedi G.: Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells. Immunity. Cell Press, 48(2): 243-257, February 2018 Notes: Featured on journal's cover and received a News and Views. Cited > 197.

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Last updated: 07/08/2024
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