Ioannis I. Verginadis
Ioannis I. Verginadis, M.Sc., Ph.D.
Research Assistant Professor of Radiation Oncology
Department: Radiation Oncology
Contact information
University of Pennsylvania, Perelman School of Medicine
3400 Civic Center Blvd., Bldg 421
Smilow Center for Translational Research, 8th Floor, Room 8-155
Philadelphia, PA 19104
3400 Civic Center Blvd., Bldg 421
Smilow Center for Translational Research, 8th Floor, Room 8-155
Philadelphia, PA 19104
Publications
Education:
B.S. (Biology)
Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece., 2006.
Ph.D. (Physiology)
Ph.D. in Physiology, Department of Physiology, School of Medicine, University of Ioannina, Ioannina, Greece., 2011.
Permanent linkB.S. (Biology)
Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece., 2006.
Ph.D. (Physiology)
Ph.D. in Physiology, Department of Physiology, School of Medicine, University of Ioannina, Ioannina, Greece., 2011.
Description of Research Expertise
Tumor microenvironment, Integrated Stress Response pathway, single-cell transcriptomics, cancer-associated fibroblasts, angiogenesis, radiation-induced gastrointestinal toxicity, radiation-induced heart disease, screening for small molecules as novel radiosensitizers/radioprotectors, FLASH radiotherapy, fibrosis, biomarkers of radiation-induced toxicity, radiation-induced inflammationSelected Publications
Priyanka Chowdhury, Anastasia Velalopoulou, Ioannis I Verginadis, George Morcos, Phoebe E Loo, Michele M Kim, Seyyedeh Azar Oliaei Motlagh, Khayrullo Shoniyozov, Eric S Diffenderfer, Emilio A Ocampo, Mary Putt, Charles-Antoine Assenmacher, Enrico Radaelli, Jiawei Lu, Ling Qin, Hengxi Liu, Nektaria Maria Leli, Swati Girdhani, Nicolas Denef, Francois Vander Stappen, Keith A Cengel, Theresa M Busch, James M Metz, Lei Dong, Alexander Lin, Constantinos Koumenis: Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer. Mol Cancer Ther June 2024 Notes: doi: 10.1158/1535-7163.MCT-23-0663.Billy W Loo Jr, Ioannis I Verginadis, Brita Singers Sørensen, Anthony E Mascia, John P Perentesis, Albert C Koong, Emil Schüler, Erinn B Rankin, Peter G Maxim, Charles L Limoli, Marie-Catherine Vozenin.: Navigating the Critical Translational Questions for Implementing FLASH in the Clinic. Semin Radiat Oncol June 2024 Notes: DOI: 10.1016/j.semradonc.2024.04.008.
Stella Logotheti, Athanasia Pavlopoulou, Hamid Khoshfekr Rudsari, Anne-Marie Galow, Yağmur Kafali, Efthymios Kyrodimos, Aris I Giotakis, Stephan Marquardt, Anastasia Velalopoulou, Ioannis I Verginadis, Constantinos Koumenis, Thorsten Stiewe, Jerome Zoidakis, Ilangko Balasingham, Robert David, Alexandros G Georgakilas: Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: The paradigm of radiotherapy. Pharmacol Ther May 2024 Notes: doi: 10.1016/j.pharmthera.2024.108670.
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Costas Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch.: p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature Communications April 2024 Notes: doi: 10.1038/s41467-024-47124-8.
Kyle Kim#, Michele M. Kim#, Giorgos Skoufos, Eric S. Diffenderfer, Seyyedeh Azar Oliaei Motlagh, Michail Kokkorakis, Ilektra Koliaki, George Morcos, Khayrullo Shoniyozov, Joanna Griffin, Artemis G. Hatzigeorgiou, James M. Metz, Alexander Lin, Steven J. Feigenberg, Keith A. Cengel, Bonnie Ky, Constantinos Koumenis, Ioannis I. Verginadis.: FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease. Int J Radiat Oncol Biol Phys February 2024 Notes: DOI: 10.1016/j.ijrobp.2024.01.224.
Zhen Lu, Eun-Ah Bae, Ioannis I Verginadis, Hongru Zhang, Christina Cho, Noreen McBrearty, Subin S George, J Alan Diehl, Constantinos Koumenis, Linda M Bradley, Serge Y Fuchs.: Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities. Cancer Immunol Immunother April 2023 Notes: DOI: 10.1007/s00262-022-03286-2.
Frank Verhaegen, Karl T Butterworth, Anthony J Chalmers, Rob P Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D Fenwick, Patrick V Granton, Stefan H J Heijmans, Mark A Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C G G Persoon, Nick Staut, Anna Subiel, Rianne D W Vaes, Stefan J van Hoof, Ioannis I Verginadis, Jan J Wilkens, Kaye J Williams, George D Wilson, Ludwig J Dubois.: Roadmap for Precision preclinical x-ray radiation studies. Physics in Medicine and Biology March 2023 Notes: DOI: 10.1088/1361-6560/acaf45.
Alexandra D. Dreyfuss, Anastasia Velalopoulou, Harris Avgousti, Brett I. Bell and Ioannis I. Verginadis.: Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers. Frontiers in Oncology October 2022 Notes: DOI: 10.3389/fonc.2022.920867.
Ioannis I. Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Kyle Kim, Nektaria Maria Leli, Ilias V. Karagounis, Brett I. Bell, Anastasia Velalopoulou, Carlo Salas Salinas, Victoria S. Wu, Yang Li, Jiangbin Ye, David A. Scott, Andrei L. Osterman, Arjun Sengupta, Aalim Weljie, Menggui Huang, Duo Zhang, Yi Fan, Enrico Radaelli, John W. Tobias, Jonathan Schug, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis G. Hatzigeorgiou, Sandra Ryeom, Alan J. Diehl, Serge Y. Fuchs, Ellen Puré, and Constantinos Koumenis.: An Integrated Stress Response Pathway activates Perivascular Cancer-Associated Fibroblasts to Drive Angiogenesis and Tumor Progression. Nature Cell Biology 24(6): 940-953, June 2022 Notes: DOI: 10.1038/s41556-022-00918-8.
Anahita Fathi Kazerooni, Sanjay Saxena, Erik Toorens, Danni Tu, Vishnu Bashyam, Hamed Akbari, Elizabeth Mamourian, Chiharu Sako, Costas Koumenis, Ioannis Verginadis, Ragini Verma, Russell T Shinohara, Arati S Desai, Robert A Lustig, Steven Brem, Suyash Mohan, Stephen J Bagley, Tapan Ganguly, Donald M O'Rourke, Spyridon Bakas, MacLean P Nasrallah, Christos Davatzikos.: Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma. Sci Rep 12(1), May 2022 Notes: DOI: 10.1038/s41598-022-12699-z.