Ioannis I. Verginadis
Ioannis I. Verginadis, M.Sc., Ph.D.
Research Assistant Professor of Radiation Oncology
Department: Radiation Oncology
Contact information
University of Pennsylvania, Perelman School of Medicine
3400 Civic Center Blvd., Bldg 421
Smilow Center for Translational Research, 8th Floor, Room 8-155
Philadelphia, PA 19104
3400 Civic Center Blvd., Bldg 421
Smilow Center for Translational Research, 8th Floor, Room 8-155
Philadelphia, PA 19104
Publications
Links
Search PubMed for articles
Perelman School of Medicine, Faculty webpage
Verginadis Lab website
Search PubMed for articles
Perelman School of Medicine, Faculty webpage
Verginadis Lab website
Education:
M.Sc. (Molecular Biology)
Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece., 2006.
B.S. (Molecular Biology)
Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece., 2006.
Ph.D. (Physiology, Radiation biology)
Ph.D. in Physiology, Department of Physiology, School of Medicine, University of Ioannina, Ioannina, Greece., 2011.
Permanent linkM.Sc. (Molecular Biology)
Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece., 2006.
B.S. (Molecular Biology)
Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece., 2006.
Ph.D. (Physiology, Radiation biology)
Ph.D. in Physiology, Department of Physiology, School of Medicine, University of Ioannina, Ioannina, Greece., 2011.
Description of Research Expertise
Tumor microenvironment, Integrated Stress Response pathway, single-cell transcriptomics, cancer-associated fibroblasts, angiogenesis, radiation-induced gastrointestinal toxicity, radiation-induced heart disease, screening for small molecules as novel radiosensitizers/radioprotectors, FLASH radiotherapy, fibrosis, biomarkers of radiation-induced toxicity, radiation-induced inflammationSelected Publications
Ioannis I. Verginadis#, Anastasia Velalopoulou#, Michele M. Kim, Kyle Kim, Ioannis Paraskevaidis, Brett Bell, Seyyedeh Azar Oliaei Motlagh, Antoneta Karaj, Esha Banerjee, Giovanni Finesso, Charles-Antoine Assenmacher, Enrico Radaelli, Jiawei Lu, Yuewei Lin, Mary E. Putt, Eric S. Diffenderfer, Chandan Guha, Ling Qin, James M. Metz, Amit Maity, Keith A. Cengel, Constantinos Koumenis, Theresa M. Busch. ((# equally contributed): FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone. Radiother Oncol April 2025 Notes: DOI: 10.1016/j.radonc.2025.110744.Anahita Fathi Kazerooni, Hamed Akbari, Xiaoju Hu, Vikas Bommineni, Dimitris Grigoriadis, Erik Toorens, Chiharu Sako, Elizabeth Mamourian, Dominique Ballinger, Robyn Sussman, Ashish Singh, Ioannis I Verginadis, Nadia Dahmane, Constantinos Koumenis, Zev A Binder, Stephen J Bagley, Suyash Mohan, Artemis Hatzigeorgiou, Donald M O'Rourke, Tapan Ganguly, Subhajyoti De, Spyridon Bakas, MacLean P Nasrallah, Christos Davatzikos: The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers. Commun Med (Lond) March 2025 Notes: DOI: 10.1038/s43856-025-00767-0.
Ioannis I Verginadis, Deborah E Citrin, Bonnie Ky, Steven J Feigenberg, Alexandros G Georgakilas, Christine E Hill-Kayser, Constantinos Koumenis, Amit Maity, Jeffrey D Bradley, Alexander Lin: Radiation-induced toxicities: mechanisms, management, and future directions. The Lancet January 2025 Notes: DOI: 10.1016/S0140-6736(24)02319-5.
Lu Z, Verginadis I, Kumazoe M, Castillo GM, Yao Y, Guerra RE, Bicher S, You M, McClung G, Qiu R, Xiao Z, Miao Z, George SS, Beiting DP, Nojiri T, Tanaka Y, Fujimura Y, Onda H, Hatakeyama Y, Nishimoto-Ashfield A, Bykova K, Guo W, Fan Y, Buynov NM, Diehl JA, Stanger BZ, Tachibana H, Gade TP, Puré E, Koumenis C, Bolotin EM, Fuchs SY.: Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies. Sci Transl Med August 2024 Notes: doi: 10.1126/scitranslmed.adn0904.
Tristan L Lim#, Clara Morral#, Ioannis I Verginadis#, Kyle Kim, Leo Luo, Caitlin J Foley, Michele M Kim, Ning Li, Benjamin Yoshor, Kizito Njah, Mary Putt, Seyyedeh Azar Oliaei Motlagh, Anastasia Velalopoulou, Priyanka Chowdhury, Sandra Bicher, Denisa Goia, Christopher J Lengner, Jeffery L Wrana, Constantinos Koumenis, Andy J Minn. (# equally contributed): Early Inflammation and Interferon Signaling Direct Enhanced Intestinal Crypt Regeneration after Proton FLASH Radiotherapy. bioRxiv August 2024 Notes: doi: 10.1101/2024.08.16.608284.
Amit U#, Uslu U#, Verginadis II#, Kim MM, Motlagh SAO, Diffenderfer ES, Assenmacher CA, Bicher S, Atoche SJ, Ben-Josef E, Young RM, June CH, Koumenis C. (# equally contributed): Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer. Proc Natl Acad Sci July 2024 Notes: doi: 10.1073/pnas.2403002121.
Priyanka Chowdhury, Anastasia Velalopoulou, Ioannis I Verginadis, George Morcos, Phoebe E Loo, Michele M Kim, Seyyedeh Azar Oliaei Motlagh, Khayrullo Shoniyozov, Eric S Diffenderfer, Emilio A Ocampo, Mary Putt, Charles-Antoine Assenmacher, Enrico Radaelli, Jiawei Lu, Ling Qin, Hengxi Liu, Nektaria Maria Leli, Swati Girdhani, Nicolas Denef, Francois Vander Stappen, Keith A Cengel, Theresa M Busch, James M Metz, Lei Dong, Alexander Lin, Constantinos Koumenis: Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer. Mol Cancer Ther June 2024 Notes: doi: 10.1158/1535-7163.MCT-23-0663.
Billy W Loo Jr, Ioannis I Verginadis, Brita Singers Sørensen, Anthony E Mascia, John P Perentesis, Albert C Koong, Emil Schüler, Erinn B Rankin, Peter G Maxim, Charles L Limoli, Marie-Catherine Vozenin.: Navigating the Critical Translational Questions for Implementing FLASH in the Clinic. Semin Radiat Oncol June 2024 Notes: DOI: 10.1016/j.semradonc.2024.04.008.
Stella Logotheti, Athanasia Pavlopoulou, Hamid Khoshfekr Rudsari, Anne-Marie Galow, Yağmur Kafali, Efthymios Kyrodimos, Aris I Giotakis, Stephan Marquardt, Anastasia Velalopoulou, Ioannis I Verginadis, Constantinos Koumenis, Thorsten Stiewe, Jerome Zoidakis, Ilangko Balasingham, Robert David, Alexandros G Georgakilas: Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: The paradigm of radiotherapy. Pharmacol Ther May 2024 Notes: doi: 10.1016/j.pharmthera.2024.108670.
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Costas Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch.: p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature Communications April 2024 Notes: doi: 10.1038/s41467-024-47124-8.