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4b Robert E. Krisch
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Robert E. Krisch, M.D., Ph.D.
5aEmeritus Associate Professor CE of Radiation Oncology
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Department: Radiation Oncology
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Contact information
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Chester County Hospital
3b 701 East Marshall Street
West Chester, PA 19380
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3b 701 East Marshall Street
West Chester, PA 19380
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Office: 800-789-PENN (7366)
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Education:
21 7 BA 1d (Natural Sciences) c
33 University of Pennsylvania, 1956.
21 9 M.D. 15 (Medicine) c
2a Temple University, 1960.
21 a Ph.D. c
33 University of Pennsylvania, 1964.
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Permanent link21 7 BA 1d (Natural Sciences) c
33 University of Pennsylvania, 1956.
21 9 M.D. 15 (Medicine) c
2a Temple University, 1960.
21 a Ph.D. c
33 University of Pennsylvania, 1964.
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151 Ayene SI, Bernhard EJ, McKenna WG, Muschel R, Krisch RE, Koch CJ: DNA as a target in radiation induced apoptosis of myc and myc plus ras transfected rat embryo fibroblasts: a radiation chemistry approach for intact cells. Int. J. Radiat. Biol 76: 343-354, 2000.
111 Ayene SI, Koch CJ, Krisch RE: Modification of radiation induced single and double strand breaks by glutathione: Comparison of single and double strand breaks in SV40 DNA. Radiat Res 144: 1-8, 1998.
f5 Ayene SI, Sullivan M, Krisch RE, Koch CJ: Protein derived radicals as sensitizers of radiation induced single and double strand DNA breaks. Radiat Res 148: 499-500, 1997.
fc Krisch RE, Ayene SI, Sullivan M, Koch CJ: A cell-like •OH scavenging environment alters the charge dependence of radiation protection by thiols. Radiat Res 148: 498-499, 1997.
fe Ayene SI, Koch CJ, Krisch RE: : Simulation of the cellular oxygen effect with an in vitro model system using double-strand DNA breaks as an endpoint. Radiat Res 146: 501-509, 1996.
e6 Ayene SI, Koch CJ, Krisch RE: Role of scavenger-derived radicals in the induction of double strand breaks in irradiated DNA. Radiat Res 142: 133-143, 1995.
166 Krisch RE, Ayene SI, Koch CJ: Interaction of Thiol and Non-Thiol Scavengers in the Modification of Radiation-Induced DNA Damage. Radiation Damage in DNA: Structure/Function Relationships at Early Times. Fuciarelli, AF, & Zimbrick, JD, Eds (eds.). Battelle Press, Page: 383-391, 1995.
13e Sause WT, Scott C, Krisch R, Rotman M, Sneed PK, Janjan N, Davis L, Curran W, Choi KN, Selim H, Mohiuddin M, Grigsby P: Phase I/II trial of accelerated fractionation in brain metastases RTOG 85-28. Int J Radiat Oncol Biol Phys 26: 653-657, 1993.
15a Curran WJ, Scott CB, Horton J, Nelson JS, Weinstein AS, Fischbach AJ, Chang CH, Rotman M, Asbell SO, Krisch RE, Nelson DF: Recursive partitioning analysis of 1,578 on 3 Radiation Therapy Oncology Group (RTOG) malignant glioma trials. J Natl Cancer Inst 85: 704-710, 1993.
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Selected Publications
13e Lee JH, Machtay MM, McKenna MG, Markiewicz DA, Krisch RE, Weinstein GS, Kligerman MM: : Radiotherapy with 6MV photons for early glottic carcinoma: potential impact of extension to the posterior vocal cord. Amer J Otolaryngol 22: 43-54, 2001.151 Ayene SI, Bernhard EJ, McKenna WG, Muschel R, Krisch RE, Koch CJ: DNA as a target in radiation induced apoptosis of myc and myc plus ras transfected rat embryo fibroblasts: a radiation chemistry approach for intact cells. Int. J. Radiat. Biol 76: 343-354, 2000.
111 Ayene SI, Koch CJ, Krisch RE: Modification of radiation induced single and double strand breaks by glutathione: Comparison of single and double strand breaks in SV40 DNA. Radiat Res 144: 1-8, 1998.
f5 Ayene SI, Sullivan M, Krisch RE, Koch CJ: Protein derived radicals as sensitizers of radiation induced single and double strand DNA breaks. Radiat Res 148: 499-500, 1997.
fc Krisch RE, Ayene SI, Sullivan M, Koch CJ: A cell-like •OH scavenging environment alters the charge dependence of radiation protection by thiols. Radiat Res 148: 498-499, 1997.
fe Ayene SI, Koch CJ, Krisch RE: : Simulation of the cellular oxygen effect with an in vitro model system using double-strand DNA breaks as an endpoint. Radiat Res 146: 501-509, 1996.
e6 Ayene SI, Koch CJ, Krisch RE: Role of scavenger-derived radicals in the induction of double strand breaks in irradiated DNA. Radiat Res 142: 133-143, 1995.
166 Krisch RE, Ayene SI, Koch CJ: Interaction of Thiol and Non-Thiol Scavengers in the Modification of Radiation-Induced DNA Damage. Radiation Damage in DNA: Structure/Function Relationships at Early Times. Fuciarelli, AF, & Zimbrick, JD, Eds (eds.). Battelle Press, Page: 383-391, 1995.
13e Sause WT, Scott C, Krisch R, Rotman M, Sneed PK, Janjan N, Davis L, Curran W, Choi KN, Selim H, Mohiuddin M, Grigsby P: Phase I/II trial of accelerated fractionation in brain metastases RTOG 85-28. Int J Radiat Oncol Biol Phys 26: 653-657, 1993.
15a Curran WJ, Scott CB, Horton J, Nelson JS, Weinstein AS, Fischbach AJ, Chang CH, Rotman M, Asbell SO, Krisch RE, Nelson DF: Recursive partitioning analysis of 1,578 on 3 Radiation Therapy Oncology Group (RTOG) malignant glioma trials. J Natl Cancer Inst 85: 704-710, 1993.
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