b6
14
4e
8
1d
2d
8
27
8
8
32
19
9
54 Eric Stanton Diffenderfer
49 16
19
1
49
2
8
1b
1d
18
79
3d
1d
2 29
1d
25
3d
Eric Stanton Diffenderfer, Ph.D.
80Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
7
69
Department: Radiation Oncology
4
1
23
1f
Graduate Group Affiliations
8
b
-
41
- Bioengineering e
1d
46
Contact information
44
4
3
3
1d
44
3400 Civic Center Blvd
2d TRC 2 West
Philadelphia, PA 19104
26
2d TRC 2 West
Philadelphia, PA 19104
35
b1
12
18
Publications
23 a
3
2
29
23 a
Links
b6 Search PubMed for articles
d
4
b
1f
b6 Search PubMed for articles
d
13
Education:
21 9 B.S. 14 (Physics) c
34 The Evergreen State College, 2001.
21 9 M.S. 14 (Physics) c
31 Florida State University, 2004.
21 a Ph.D. 1c (Nuclear Physics) c
31 Florida State University, 2007.
c
3
3
3
3
92
Permanent link21 9 B.S. 14 (Physics) c
34 The Evergreen State College, 2001.
21 9 M.S. 14 (Physics) c
31 Florida State University, 2004.
21 a Ph.D. 1c (Nuclear Physics) c
31 Florida State University, 2007.
c
2 29
21
1e
1d
24
5e
21 Proton SARRP development.
2a Proton and neutron microdosimetry.
3b Machine learning applications in Radiation Oncology.
65
1a 29
27
Description of Research Expertise
24 FLASH radiotherapy.21 Proton SARRP development.
2a Proton and neutron microdosimetry.
3b Machine learning applications in Radiation Oncology.
65
Description of Clinical Expertise
3f Proton and X-ray therapy physics and dosimetry.1a 29
23
1ef Zou W, Dong L, Pin A, Nilsson R, Kim M, Apinorasethkul O, Pakela J, Friberg A, Koger B, Labarbe R, Fuentes CL, Cengel K, Traneus E, Girdhani S, Koumenis C, Vander Stappen F, Diffenderfer E, Bradley J, Teo BK, Lin A.: Deliverable proton conformal FLASH radiotherapy treatment planning for head and neck re-irradiation patients. Radiotherapy and Oncology 216: 111349, December 2025 Notes: doi: 10.1016/j.radonc.2025.111349.
1bc Arash Darafsheh, Yao Hao, Anissa Bey, Michele M Kim, Eric S Diffenderfer, Lingshu Yin, Chin-Cheng Chen, Zhiyan Xiao, S Murty Goddu, Gabriele Zorloni: First multi-institutional systematic comparison of the neutron ambient dose equivalent produced by proton therapy systems. Physics in Medicine and Biology 70, November 2025 Notes: https://doi.org/10.1088/1361-6560/ae1ee5.
194 Lucian Hotoiu, Francois Vander Stappen, Arnaud Pin, Rasmus Nilsson, Justin Ivoc, Michele Kim, Eric Diffenderfer, Boon-Keng Kevin Teo, Rudi Labarbe: Experimental validation of coarse ridge filters for FLASH proton therapy. Medical Physics 52(9), September 2025 Notes: https://doi.org/10.1002/mp.18044Digital Object Identifier (DOI).
1ad Friberg AM, Tan HS, Diffenderfer ES, Verginadis I, Kim MM, Cengel K, Wiersma R, Dong L, Koumenis C, Teo BK, Zou W.: Physicochemical indication of the FLASH effect from shoot-through proton pencil beam scanning parameters delivered under ultra-high dose rates. Physics in Medicine and Biology 70(17):175002, August 2025 Notes: doi: 10.1088/1361-6560/adf58e.
370 Arpit M. Chhabra MD, Richard A. Amos MSc, FIPEM, Charles B. Simone II, MD, Adeel Kaiser MD, Luis A. Perles PhD, Huan Giap MD, PhD, Christopher L. Hallemeier MD, Jedediah E. Johnson PhD, Haibo Lin PhD, Andrew J. Wroe PhD, Eric S. Diffenderfer PhD, John A. Wolfgang PhD, Hideyuki Sakurai MD, Hsiao-Ming Lu PhD, Theodore S. Hong MD, Eugene J. Koay MD, PhD, Kazuki Terashima PhD, Pavel Vitek PhD, William G. Rule MD, Smith Jim Apisarnthanarax MD, Shahed N. Badiyan MD, Jason K. Molitoris MD, PhD, Michael Chuong MD, Romaine C. Nichols Jr. MD: Proton Beam Therapy for Pancreatic Tumors: A Consensus Statement from the Particle Therapy Cooperative Group Gastrointestinal Subcommittee. International Journal of Radiation Oncology • Biology • Physics 122(1), May 2025 Notes: doi: 10.1016/j.ijrobp.2024.12.020.
1e2 Seyyedeh Azar Oliaei Motlagh, François Vander Stappen, Michele M Kim, Rudi Labarbe, Lucian Hotoiu, Arnaud Pin, Rasmus Nilsson, Erik Traneus, Keith A Cengel, Wei Zou, Boon-Keng Kevin Teo, Lei Dong, Eric S Diffenderfer : Verification of dose and dose rate for quality assurance of spread-out-Bragg-peak proton FLASH radiotherapy using machine log files. Medical Physics April 2025 Notes: DOI: 10.1002/mp.17792.
253 Haiwei Ni, Zachary J Reitman, Wei Zou, Md Naushad Akhtar, Ritama Paul, Menggui Huang, Duo Zhang, Hao Zheng, Ruitao Zhang, Ruiying Ma, Gina Ngo, Lin Zhang, Eric S Diffenderfer, S Azar Oliaei Motlagh, Michele M Kim, Andy J Minn, Jay F Dorsey, Jessica B Foster, James Metz, Constantinos Koumenis, David G Kirsch, Yanqing Gong, Yi Fan : FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy. Nature Cancer February 2025 Notes: DOI: 10.1038/s43018-025-00905-6.
2ac Ioannis I Verginadis, Anastasia Velalopoulou, Michele M Kim, Kyle Kim, Ioannis Paraskevaidis, Brett Bell, Seyyedeh Azar Oliaei Motlagh, Antoneta Karaj, Esha Banerjee, Giovanni Finesso, Charles-Antoine Assenmacher, Enrico Radaelli, Jiawei Lu, Yuewei Lin, Mary E Putt, Eric S Diffenderfer, Chandan Guha, Ling Qin, James M Metz, Amit Maity, Keith A Cengel, Constantinos Koumenis, Theresa M Busch : FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone. Radiotherapy and Oncology January 2025 Notes: DOI: 10.1016/j.radonc.2025.110744.
17f Wenbo Gu, Alejandro Garcia, Lingshu Yin, Alexander Lin, Jennifer Wei Zou, Lei Dong, Eric S Diffenderfer, Michele M Kim, Kai Mei, Peter B Noėl, Boon-Keng Kevin Teo: Universal Range Modulators for Flash Proton Therapy: 3D Printing of Stackable Variable Density Units. AAPM 67th Annual Meeting & Exhibition 2025.
2c
7
1d
1f
Selected Publications
13b Diffenderfer, E., Nakamura, S., Masuda, A., Tanaka, H.: Neutron Detectors and Measuring Methods. Radiation Detectors and Methods in Medicine. Das, I.J. (eds.). Springer Nature, January 2026 Notes: https://doi.org/10.1007/978-3-032-10159-4_19.1ef Zou W, Dong L, Pin A, Nilsson R, Kim M, Apinorasethkul O, Pakela J, Friberg A, Koger B, Labarbe R, Fuentes CL, Cengel K, Traneus E, Girdhani S, Koumenis C, Vander Stappen F, Diffenderfer E, Bradley J, Teo BK, Lin A.: Deliverable proton conformal FLASH radiotherapy treatment planning for head and neck re-irradiation patients. Radiotherapy and Oncology 216: 111349, December 2025 Notes: doi: 10.1016/j.radonc.2025.111349.
1bc Arash Darafsheh, Yao Hao, Anissa Bey, Michele M Kim, Eric S Diffenderfer, Lingshu Yin, Chin-Cheng Chen, Zhiyan Xiao, S Murty Goddu, Gabriele Zorloni: First multi-institutional systematic comparison of the neutron ambient dose equivalent produced by proton therapy systems. Physics in Medicine and Biology 70, November 2025 Notes: https://doi.org/10.1088/1361-6560/ae1ee5.
194 Lucian Hotoiu, Francois Vander Stappen, Arnaud Pin, Rasmus Nilsson, Justin Ivoc, Michele Kim, Eric Diffenderfer, Boon-Keng Kevin Teo, Rudi Labarbe: Experimental validation of coarse ridge filters for FLASH proton therapy. Medical Physics 52(9), September 2025 Notes: https://doi.org/10.1002/mp.18044Digital Object Identifier (DOI).
1ad Friberg AM, Tan HS, Diffenderfer ES, Verginadis I, Kim MM, Cengel K, Wiersma R, Dong L, Koumenis C, Teo BK, Zou W.: Physicochemical indication of the FLASH effect from shoot-through proton pencil beam scanning parameters delivered under ultra-high dose rates. Physics in Medicine and Biology 70(17):175002, August 2025 Notes: doi: 10.1088/1361-6560/adf58e.
370 Arpit M. Chhabra MD, Richard A. Amos MSc, FIPEM, Charles B. Simone II, MD, Adeel Kaiser MD, Luis A. Perles PhD, Huan Giap MD, PhD, Christopher L. Hallemeier MD, Jedediah E. Johnson PhD, Haibo Lin PhD, Andrew J. Wroe PhD, Eric S. Diffenderfer PhD, John A. Wolfgang PhD, Hideyuki Sakurai MD, Hsiao-Ming Lu PhD, Theodore S. Hong MD, Eugene J. Koay MD, PhD, Kazuki Terashima PhD, Pavel Vitek PhD, William G. Rule MD, Smith Jim Apisarnthanarax MD, Shahed N. Badiyan MD, Jason K. Molitoris MD, PhD, Michael Chuong MD, Romaine C. Nichols Jr. MD: Proton Beam Therapy for Pancreatic Tumors: A Consensus Statement from the Particle Therapy Cooperative Group Gastrointestinal Subcommittee. International Journal of Radiation Oncology • Biology • Physics 122(1), May 2025 Notes: doi: 10.1016/j.ijrobp.2024.12.020.
1e2 Seyyedeh Azar Oliaei Motlagh, François Vander Stappen, Michele M Kim, Rudi Labarbe, Lucian Hotoiu, Arnaud Pin, Rasmus Nilsson, Erik Traneus, Keith A Cengel, Wei Zou, Boon-Keng Kevin Teo, Lei Dong, Eric S Diffenderfer : Verification of dose and dose rate for quality assurance of spread-out-Bragg-peak proton FLASH radiotherapy using machine log files. Medical Physics April 2025 Notes: DOI: 10.1002/mp.17792.
253 Haiwei Ni, Zachary J Reitman, Wei Zou, Md Naushad Akhtar, Ritama Paul, Menggui Huang, Duo Zhang, Hao Zheng, Ruitao Zhang, Ruiying Ma, Gina Ngo, Lin Zhang, Eric S Diffenderfer, S Azar Oliaei Motlagh, Michele M Kim, Andy J Minn, Jay F Dorsey, Jessica B Foster, James Metz, Constantinos Koumenis, David G Kirsch, Yanqing Gong, Yi Fan : FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy. Nature Cancer February 2025 Notes: DOI: 10.1038/s43018-025-00905-6.
2ac Ioannis I Verginadis, Anastasia Velalopoulou, Michele M Kim, Kyle Kim, Ioannis Paraskevaidis, Brett Bell, Seyyedeh Azar Oliaei Motlagh, Antoneta Karaj, Esha Banerjee, Giovanni Finesso, Charles-Antoine Assenmacher, Enrico Radaelli, Jiawei Lu, Yuewei Lin, Mary E Putt, Eric S Diffenderfer, Chandan Guha, Ling Qin, James M Metz, Amit Maity, Keith A Cengel, Constantinos Koumenis, Theresa M Busch : FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone. Radiotherapy and Oncology January 2025 Notes: DOI: 10.1016/j.radonc.2025.110744.
17f Wenbo Gu, Alejandro Garcia, Lingshu Yin, Alexander Lin, Jennifer Wei Zou, Lei Dong, Eric S Diffenderfer, Michele M Kim, Kai Mei, Peter B Noėl, Boon-Keng Kevin Teo: Universal Range Modulators for Flash Proton Therapy: 3D Printing of Stackable Variable Density Units. AAPM 67th Annual Meeting & Exhibition 2025.
2c