Department of Radiation Oncology

Eric Diffenderfer

faculty photo

Eric Diffenderfer, Ph.D.

Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
B.S. (Physics)
The Evergreen State College, 2001.
M.S. (Physics)
Florida State University, 2004.
Ph.D. (Nuclear Physics)
Florida State University, 2007.
Permanent link
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Description of Research Expertise

FLASH radiotherapy.
Proton SARRP development.
Proton and neutron microdosimetry.
Machine learning applications in Radiation Oncology.

Description of Clinical Expertise

Proton and X-ray therapy physics and dosimetry.

Selected Publications

Luna, José Marcio; Barsky, Andrew R; Shinohara, Russell T; Roshkovan, Leonid; Hershman, Michelle; Dreyfuss, Alexandra D; Horng, Hannah; Lou, Carolyn; Noël, Peter B; Cengel, Keith A; Katz, Sharyn; Diffenderfer, Eric S*; Kontos, Despina*: Radiomic Phenotypes for Improving Early Prediction of Survival in Stage III Non-Small Cell Lung Cancer Adenocarcinoma after Chemoradiation. Cancers January 2022 Notes: * denotes co-senior authorship,

Busch, T., Velalopoulou, A., Karagounis, I., Cramer, G., Skoufos, G., Hatzigeorgiou, A. G., Lanza, M., Radaelli, E., Assenmacher, C. A., Putt, M., Kim, M., Diffenderfer, E., Dong, L., Metz, J., Koumenis, C., Cengel, K., Maity, A.: FLASH Mechanisms Track MECHANISMS OF FLASH RADIOTHERAPY SPARING OF NORMAL TISSUE AS INFORMED BY RNA-SEQ TRANSCRIPTOME ANALYSES. Physica Medica 94: S5-S5, 2022.

Khatib, Mirna El; Van Slyke, Alexander L.; Velalopoulou, Anastasia; Kim, Michele M.; Shoniyozov, Khayrullo; Allu, Srinivasa Rao; Diffenderfer, Eric S.; Busch, Theresa M.; Wiersma, Rodney D.; Koch, Cameron J.; Vinogradov, Sergei A.: Ultrafast Tracking of Oxygen Dynamics during Proton FLASH. International Journal of Radiation Oncology • Biology • Physics 2022 Notes: DOI: 10.1016/j.ijrobp.2022.03.016.

Zou, W., Kim, H., Diffenderfer, E., Carlson, D., Koch, C., Xiao, Y., Teo, B., Metz, J., Maity, A., Koumenis, C., Cengel, K., Dong, L.: FLASH OXYGEN DEPLETION EFFECTS DEPEND ON TISSUE VASCULATURE STRUCTURE: A SIMULATION STUDY ON SMALL ANIMAL PROTON FLASH EXPERIMENT. Physica Medica 94: S73-S74, 2022.

Verginadis, I., Luo, L., Martinez, C. Morral, Foley, C., Velalopoulou, A., Kim, M., Goia, D., Reitman, Z., Daniel, A., Diffenderfer, E., Dong, L., Metz, J., Kirsch, D., Minn, A., Koumenis, C.: FLASH Mechanisms Track (Oral Presentations) PRECLINICAL STUDIES WITH PROTON FLASH RADIOTHERAPY: BIOLOGICAL EFFECTS AND POTENTIAL MECHANISMS. Physica Medica 94: S55-S55, 2022.

Velalopoulou, A., Karagounis, I., Cramer, G., Kim, M., Skoufos, G., Goia, D., Hagan, S., Verginadis, I., Shoniyozov, K., Chiango, J., Cerullo, M., Varner, K., Yao, L., Qin, L., Hatzigeorgiou, A. G., Minn, A., Putt, M., Lanza, M., Assenmacher, C. A., Radaelli, E., Huck, J., Diffenderfer, E., Dong, L., Metz, J., Koumenis, C., Cengel, K., Maity, A., Busch, T.: FLASH Mechanisms Track (Oral Presentations) FLASH PROTON RADIOTHERAPY IS EQUIPOTENT TO STANDARD RADIATION IN TREATMENT OF MURINE SARCOMAS WHILE REDUCING TOXICITIES TO NORMAL SKIN, MUSCLE AND BONE. Physica Medica 94: S9-S9, 2022 Notes: oral presentation.

El Khatib, M., Van Slyke, A., Velalopoulou, A., Shoniyozov, K., Diffenderfer, E., Kim, M., Karagounis, I., Busch, T., Wiersma, R., Koch, C., Vinogradov, S.: FLASH Mechanisms Track (Oral Presentations) ULTRAFAST TRACKING OF OXYGEN DYNAMICS DURING PROTON FLASH. Physica Medica 94: S31-S31, 2022 Notes: oral presentation.

Cengel, K., Kim, M., Diffenderfer, E., Karagounis, I., Cramer, G., Skoufos, G., Hatzigeorgiou, A. G., Lanza, M., Assenmacher, C. A., Radaelli, E., Putt, M., Hagan, S., Chiango, J., Shoniyozov, K., Dong, L., Koumenis, C., Maity, A., Busch, T., Metz, J., Huck, J.: FLASH in the Clinic Track (Oral Presentations) A RANDOMIZED DOSE ESCALATION STUDY OF FLASH VS STANDARD DOSE RATE PROTON RADIOTHERAPY FOR CANINE OSTEOSARCOMA. Physica Medica 94: S24-S24, 2022 Notes: oral presentation.

Tatiana A. Karakasheva, Joel T. Gabre, Uma M. Sachdeva, Ricardo Cruz-Acuña, Eric W. Lin, Maureen DeMarshall, Gary W. Falk, Gregory G. Ginsberg, Zhaohai Yang, Michele M. Kim, Eric S. Diffenderfer, Jason R. Pitarresi, Jinyang Li, Amanda B. Muir, Kathryn E. Hamilton, Hiroshi Nakagawa, Adam J. Bass & Anil K. Rustgi: Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer. Scientific Reports 11(1), October 2021 Notes: doi: 10.1038/s41598-021-00706-8.

Anastasia Velalopoulou, Ilias V. Karagounis, Gwendolyn M. Cramer, Michele M. Kim, Giorgos Skoufos, Denisa Goia, Sarah Hagan, Ioannis I. Verginadis, Khayrullo Shoniyozov, June Chiango, Michelle Cerullo, Kelley Varner, Lutian Yao, Ling Qin, Artemis G. Hatzigeorgiou, Andy J. Minn, Mary Putt, Matthew Lanza, Charles-Antoine Assenmacher, Enrico Radaelli, Jennifer Huck, Eric Diffenderfer, Lei Dong, James Metz, Constantinos Koumenis, Keith A. Cengel, Amit Maity and Theresa M. Busch: FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Cancer Research September 2021 Notes: DOI: 10.1158/0008-5472.CAN-21-1500.

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Last updated: 05/11/2022
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