Department of Radiation Oncology

Alexander Lin

faculty photo

Alexander Lin, M.D.

Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
University of Pennsylvania
Department of Radiation Oncology
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
Office: 215-662-3198
Fax: 215-349-5445
B.A. (Molecular Biophysics and Biochemistry)
Yale University, 1998.
M.D. (Medicine)
University of Michigan Medical School, 2002.
Other (Certificate in Financial Accounting)
Harvard Business School Online, 2019.
Permanent link
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Description of Clinical Expertise

Dr. Lin is Chief of the Head and Neck Oncology Service in the Department of Radiation Oncology at Penn Medicine. Dr. Lin specializes in the multidisciplinary approach to treatment of cancers of the head and neck. He works collaboratively with members of the Departments of Otorhinolaryngology (ENT), Medical Oncology, Pathology, Diagnostic Radiology, Oral Medicine, and Nuclear Medicine with a focus on improving cancer control, outcomes, and quality of life for patients.

Description of Other Expertise

Dr. Lin is the Vice Chair of Faculty Affairs in the Department of Radiation Oncology at the University of Pennsylvania. In this role, he leads departmental efforts in establishing a robust and active program for mentorship and professional development for faculty members of the Department of Radiation Oncology.

Description of Research Expertise

Alexander Lin, M.D., is Associate Professor in the Department of Radiation Oncology at the Perelman School of Medicine, and the Medical Director of the Roberts Proton Therapy Center at the University of Pennsylvania. Dr. Lin leads research programs in personalized approaches in the multidisciplinary treatment of head and neck cancer. Dr. Lin leads studies in novel methods of toxicity mitigation in patients with Human Papillomavirus (HPV)-associated cancers of the oropharynx. He also specializes in clinical trials investigating new radiosensitizing agents targeting the tumor microenvironment to improve disease outcomes, for which he receives funding from the National Cancer Institute (NCI) and National Institutes of Health (NIH).

Dr. Lin completed his undergraduate studies at Yale University and his medical training at the University of Michigan. He is a board-certified radiation oncologist and practicing physician at the University of Pennsylvania, Perelman School of Medicine.

Selected Publications

Grewal AS, Rajasekaran K, Cannady SB, Chalian AA, Ghiam AF, Lin A, LiVolsi V, Lukens JN, Mitra N, Montone KT, Newman JG, O’Malley Jr. BW, Rassekh CH, Weinstein GS, Swisher-McClure S: Pharyngeal Sparing Radiation for Head and Neck Carcinoma of Unknown Primary following TORS work-up The Laryngoscope 130(3): 691-697, March 2020.

Swisher-McClure S, Lukens JN, Aggarwal C, Ahn P, Basu D, Bauml JM, Brody R, Chalian A, Cohen RB, Fotouhi-Ghiam A, Geiger G, Gershowitz J, Livolsi V, Mick R, Mitra N, Montone K, Newman J, Ojerholm E, O’Malley Jr. B, Rajasekeran K, Tan E, Weinstein G, Lin A: A Phase 2 Trial of Alternative Volumes of Oropharyngeal Irradiation for De-intensification: Omission of the Resected Primary Tumor Bed Following Transoral Robotic Surgery for Human Papilloma Virus Related Squamous Cell Carcinoma of the Oropharynx. International Journal of Radiation Oncology, Biology, Physics 106(4): 725-732, March 2020.

Hague C, Aznar MC, Li T, O’Reilly S, Dong L, Fotouhi-Ghiam A, Lee LW, Lowe M, Lukens JN, McPartlin A, Slevin N, Swisher-McClure S, Thomson D, van Herk M, West C, Zou W, Lin A, Teo BK.: Inter-fraction Robustness of Intensity-Modulated Proton Therapy in the Post-operative Treatment of Oropharyngeal and Oral Cavity Squamous Cell Carcinomas. British Journal of Radiology 93(1107): 20190638, March 2020.

Diffenderfer ES, Kim MM, Verginadi II, Shoniyozov K, Hagan S, Avery S, Teo K, Zou W, Lin A, Swisher-McClure S, Koch C, Kennedy AR, Maity A, Busch TM, Dong L, Koumenis C, Metz J, Cengel KA: Design, Implementation and In Vivo Validation of a Novel Proton FLASH Radiotherapy System International Journal of Radiation Oncology, Biology, Physics 106(2): 440-448, February 2020.

Chao HH, Schonewolf C, Tan E, Swisher-McClure SS, Ghiam AF, Weinstein GS, O’Malley Jr BW, Chalian AA, Rassekh CH, Newman JG, Cohen RB, Bauml JM, Aggarwal C, Lin A*, Lukens JN*: The Impact of Treatment Package Time on Locoregional Control for HPV+ Oropharyngeal Squamous Cell Carcinoma Treated with Surgery and Postoperative (Chemo)Radiation. Head and Neck 41(11): 3858-3868, November 2019.

Gershowitz J, Chao HH, Doucette A, Lukens JN, Swisher-McClure S, Weinstein GS, O’Malley Jr BW, Chalian AA, Rassekh CH, Newman JG, Cohen RB, Bauml JM, Aggarwal C, Lin A : Risk of Post-Operative, Pre-Radiotherapy Contralateral Neck Recurrence in Patients Treated with Surgery Followed by Adjuvant Radiotherapy for Human Papilloma Virus-Associated Tonsil Cancer. British Journal of Radiology 92: 20190466, October 2019.

Men K, Geng H, Zhong H, Fan Y, Lin A, Xiao Y : A deep learning model for predicting xerostomia due to radiotherapy for head-and-neck squamous cell carcinoma in the RTOG 0522 clinical trial International Journal of Radiation Oncology, Biology, Physics 105(2): 440-447, October 2019.

Grewal A, Jones J, Lin A: Palliative radiation therapy for head and neck cancers International Journal of Radiation Oncology, Biology, Physics 105(2): 254-266, October 2019.

Baumann B, Lustig R, Mazzoni S, Grady MS, O'Malley Jr. B, Lee J, Newman J, Schuster J, Both S, Lin A, Dorsey J, Alonso-Basanta M : A Prospective Clinical Trial of Proton Therapy for Chordoma and Chondrosarcoma: Feasibility Assessment. Journal of Surgical Oncology 120(2): 200-205, August 2019.

Rwigema JM, Langendijk JA, van der Laan HP, Lukens JN, Swisher-McClure SD, Lin A: A model-based approach to predict short-term toxicity benefits with proton therapy for oropharyngeal cancer. International Journal of Radiation Oncology, Biology, Physics 104(3): 553-562, July 2019.

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Last updated: 05/26/2020
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