Alexander Lin

faculty photo

Alexander Lin, M.D.

Morton M. Kligerman Professor
Department: Radiation Oncology

Contact information
University of Pennsylvania
Department of Radiation Oncology
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
Office: 215-662-3198
Fax: 215-349-5445
B.A. (Molecular Biophysics and Biochemistry)
Yale University, 1998.
M.D. (Medicine)
University of Michigan Medical School, 2002.
Other (Certificate in Financial Accounting)
Harvard Business School Online, 2019.
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Description of Clinical Expertise

Dr. Lin specializes in the multidisciplinary approach to treatment of cancers of the head and neck. He works collaboratively with members of the Departments of Otorhinolaryngology (ENT), Medical Oncology, Pathology, Diagnostic Radiology, Oral Medicine, and Nuclear Medicine with a focus on improving cancer control, outcomes, and quality of life for patients.

Description of Other Expertise

Dr. Lin is the Vice Chair of Faculty Affairs in the Department of Radiation Oncology at the University of Pennsylvania. In this role, he leads departmental efforts in establishing a robust and active program for mentorship and professional development for faculty members of the Department of Radiation Oncology.

Description of Research Expertise

Alexander Lin, M.D., is the Morton M. Kligerman, MD Endowed Professor of Radiation Oncology. Dr. Lin leads research programs in personalized approaches in the multidisciplinary treatment of head and neck cancer. Dr. Lin leads studies in novel methods of toxicity mitigation in patients with Human Papillomavirus (HPV)-associated cancers of the oropharynx. He also specializes in clinical trials investigating new radiosensitizing agents targeting the tumor microenvironment to improve disease outcomes, for which he receives funding from the National Cancer Institute (NCI) and National Institutes of Health (NIH).

Dr. Lin completed his undergraduate studies at Yale University and his medical training at the University of Michigan. He is a board-certified radiation oncologist and practicing physician at the University of Pennsylvania, Perelman School of Medicine.

Selected Publications

Lu J, Cao A, Shimunov D, Sun L, Lukens J, Lin A, Cohen R, Basu D, Cannady S, Rajasekaran K, Weinstein G, Brody R: Functional Outcomes in Patients with HPV+ Oropharyngeal Squamous Cell Cancer Treated with Trimodality Therapy. The Laryngoscope Page: 1-8, 2023.

Kim KN, Harton J, Mitra N, Lukens JN, Lin A, Amaniera I, Doucette A, Gabriel P, Baumann B, Metz J,Andrzej Wojcieszynski A: Acute toxicity in patients treated with concurrent chemoradiotherapy with proton versus intensity-modulated radiation therapy for nonmetastatic head and neck cancers. Head and Neck 44(11): 2386-2394, November 2022 Notes:

Chawla S, Loevner LA, Mohan S, Lin A, Sehgal CM, Poptani H : Dynamic Contrast Enhanced -MRI and Doppler Sonography in Patients with Squamous Cell Carcinoma of Head and Neck Treated with Induction Chemotherapy. Journal of Clinical Ultrasound 50(9): 1353-1359, November 2022.

Su W, Wright CM, Lee DY, Kim M, Anstadt EJ, Teo BK, Carlson DJ, Lukens JN, Eisbruch A, Lin A: Stricter Postoperative Oropharyngeal Cancer Radiotherapy Normal Tissue Dose Constraints Are Feasible. Practical Radiation Oncology 12(4): e282-e285, Jul-Aug 2022.

Brennan MT, Treister NS, Sollecito TP, Schmidt BL, Patton LL, Lin A, Elting LS, Hodges JS, Lalla RV : Tooth failure post-radiotherapy in head and neck cancer International Journal of Radiation Oncology, Biology, Physics 113(2): 320-330, June 2022.

Lalla RV, Treister NS, Sollecito TP, Schmidt BS, Patton LL, Helgeson ES, Lin A, Rybczyk C, Dowsett R, Hegde U, Boyd TS, Duplinsky TG, Brennan MT: Radiation Therapy for Head and Neck Cancer Leads to Gingival Recession Associated With Dental Caries Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 133(5): 539-546, May 2022.

Brennan MT, Treister NS, Sollecito TP, Schmidt BL, Patton LL, Lin A, Elting LS, Helgeson ES, Lalla RV: Dental Caries Postradiotherapy in Head and Neck Cancer. JDR Clin Trans Res Page: 23800844221086563, April 2022.

Lin A, Helgeson ES, Treister NS, Schmidt BL, Patton LL, Elting LS, Lalla RV, Brennan MT, Sollecito TP, : The Impact of Head and Neck Radiotherapy on Salivary Flow and Quality of Life: Results of the ORARAD Study. Oral Oncology 127: 105783, April 2022.

Brody RM, Shimunov D, Cohen RB, Lin A, Swisher-McClure S, Lukens JN, Bauml JM, Hartner L, Aggarwal C, Duvvuri U, Montone KT, Jalaly JB, LiVolsi VA, Shanti RM, Rajasekaran K, Chalian AA, Rassekh CH, Cannady SB, Newman JG, O’Malley Jr BW, Weinstein GS, Gimotty PA, Basu D: A benchmark for oncologic outcomes and model for lethal recurrence risk after transoral robotic resection of HPV-related oropharyngeal cancers Oral Oncology 127: 105798, April 2022.

Caissie A, Mierzwa M, Fuller CD, Rajaraman M, Lin A, MacDonald A, Popple R, Xiao Y, van Dijk L, Balter P, Fong H, Ping H, Kavoor M, Lee J, Rao A, Thompson R, Martel M, Merz B, Mayo C: Head and Neck Radiotherapy Patterns of Practice Variability Identified as a Challenge to Real-World Big Data: results from the Learning from Analysis of Multicentre Big Data Aggregation (LAMBDA) Consortium. Advances in Radiation Oncology 8(1): 100925, February 2022.

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Last updated: 06/02/2023
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