Department of Radiation Oncology

Lei Dong

faculty photo

Lei Dong, Ph.D.

Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Perelman Center for Advanced Medicine
Department of Radiation Oncology
3400 Civic Center Blvd
Philadelphia, PA 19104
Education:
B.S. (Engineering Physics)
Tsinghua University, 1985.
M.S. (Modern Applied Physics)
Tsinghua University, 1987.
Ph.D. (Biomedical Sciences/Medical Physics Program)
University of Texas Graduate School of Biomedical Sciences, 1995.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Dr.Dong is familiar with radiation dosimetry and use of images in radiation oncology for setup (IGRT) and treatment planning. He was involved in several auto-segmentation projects using deformable image registration or machine learning methods. In addition, Dr.Dong worked extensively in the technical commissioning in three proton therapy centers (Hitachi Synchrotron at MD Anderson Cancer Center in 2005-2008, Varian first ProBeam pencil beam scanning at Scripps Health in 2012-2016, and IBA multi-room cyclotron-based system with upgraded dedicated pencil beam scanning technology since 2017).

Description of Research Expertise

My research interests are always motivated by clinical needs. As a medical physicist, the use of advanced technologies to improve clinical outcomes or clinical efficiencies is always interesting to me. Throughout the years, I have been interested in intensity-modulated radiation therapy, which includes proton therapy and automated treatment planning; I am interested in adaptive radiotherapy beyond anatomical changes of patient’s anatomy; I am interested in imaging, which provides rich information about the patient (spatially or biologically); I am interested in novel treatment techniques, which includes the recent hot topic on ultra-high dose-rate radiation therapy (FLASH). I have published over 220 peer-reviewed papers and 15 book chapters. My publication h-index is around 62. I plan to continue my innovative research through close collaboration with researchers internally and around the world.

Selected Publications

Velalopoulou, A., Karagounis, I. V., Cramer, G. M., Kim, M. M., Skoufos, G., Goia, D., Hagan, S., Verginadis,, II, Shoniyozov, K., Chiango, J., Cerullo, M., Varner, K., Yao, L., Qin, L., Hatzigeorgiou, A. G., Minn, A. J., Putt, M., Lanza, M., Assenmacher, C. A., Radaelli, E., Huck, J., Diffenderfer, E., Dong, L., Metz, J., Koumenis, C., Cengel, K. A., Maity, A., Busch, T. M.: FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Cancer Research 2021.

Gu, W., Ruan, D., Zou, W., Dong, L., Sheng, K.: Linear energy transfer weighted beam orientation optimization for intensity-modulated proton therapy. Med Phys 48(1): 57-70, 2021.

Velalopoulou, A., Karagounis, I. V., Cramer, G. M., Kim, M. M., Skoufos, G., Goia, D., Hagan, S., Verginadis,, II, Shoniyozov, K., Chiango, J., Cerullo, M., Varner, K., Yao, L., Qin, L., Hatzigeorgiou, A. G., Minn, A. J., Putt, M., Lanza, M., Assenmacher, C. A., Radaelli, E., Huck, J., Diffenderfer, E., Dong, L., Metz, J., Koumenis, C., Cengel, K. A., Maity, A., Busch, T. M.: FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response. Cancer Res 81(18): 4808-4821, 2021.

Zhang, Y., Zhang, L., Court, L. E., Balter, P., Dong, L., Yang, J.: Tissue-specific deformable image registration using a spatial-contextual filter. Comput Med Imaging Graph 88: 101849, 2021.

Zhu, T. C., Ong, Y., Sun, H., Zhong, W., Miao, T., Dimofte, A., Bruza, P., Maity, A., Plastaras, J. P., Paydar, I., Dong, L., Pogue, B. W.: Cherenkov imaging for Total Skin Electron Therapy - an evaluation of dose uniformity. Proc SPIE Int Soc Opt Eng 11628, 2021.

Zou, W., Diffenderfer, E. S., Cengel, K. A., Kim, M. M., Avery, S., Konzer, J., Cai, Y., Boisseu, P., Ota, K., Yin, L., Wiersma, R., Carlson, D. J., Fan, Y., Busch, T. M., Koumenis, C., Lin, A., Metz, J. M., Teo, B. K., Dong, L.: Current delivery limitations of proton PBS for FLASH. Radiother Oncol 155: 212-218, 2021.

Zou, W., Diffenderfer, E. S., Ota, K., Boisseau, P., Kim, M. M., Cai, Y., Avery, S. M., Carlson, D. J., Wiersma, R. D., Lin, A., Koumenis, C., Cengal, K., Metz, J. M., Dong, L., Teo, B. K.: Characterization of a high-resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery. Med Phys 2021.

Zou, W., Kurtz, G., Nakib, M., Burgdorf, B., Alp, M., Li, T., Lustig, R., Xiao, Y., Dong, L., Kassaee, A., Alonso-Basanta, M.: A Probability-Based Investigation on the Setup Robustness of Pencil-beam Proton Radiation Therapy for Skull-Base Meningioma. Int J Part Ther 7(3): 34-45, 2021.

Kassaee, A., Cheng, C., Yin, L., Zou, W., Li, T., Lin, A., Swisher-McClure, S., Lukens, J. N., Lustig, R. A., O'Reilly, S., Dong, L., Ms, R. H., Teo, B. K.: Dual-Energy Computed Tomography Proton-Dose Calculation with Scripting and Modified Hounsfield Units. Int J Part Ther 8(1): 62-72, 2021.

Kim, M. M., Verginadis,, II, Goia, D., Haertter, A., Shoniyozov, K., Zou, W., Maity, A., Busch, T. M., Metz, J. M., Cengel, K. A., Dong, L., Koumenis, C., Diffenderfer, E. S.: Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model. Cancers (Basel) 13(16), 2021.

back to top
Last updated: 10/15/2021
The Trustees of the University of Pennsylvania
 
Top

© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.