Leslie M. Shaw

faculty photo
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Director, Alzheimer's Disease Neuroimaging, Initiative Biomarker Core Laboratory, University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Hospital of the University of Pennsylvania
7.103 Founders Pavilion 3400 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-6575
Fax: (215) 662-7529
B.S. (Cum Laude, Chemistry)
LeMoyne College, Syracuse, New York, 1962.
Ph.D. (Biochemistry)
S.U.N.Y. at Upstate Medical Center, 1968.
Post-Graduate Training
NIH Post doctoral Fellowship Department of Molecular Biology, The Johns Hopkins University, Baltimore, MD, 1968-1970.
Fellow, Neuroscience Research Program, 1969-1969.
NIH Postdoctoral Fellowship, William Pepper Laboratories, Hospital of the University of Pennsylvania, Philadelphia, PA, 1970-1972.
American Board of Clinical Chemistry, 1973.
American Board of Clinical Chemistry in Toxicological Chemistry, 1990.
USC School of Medicine, Laboratory of Applied Pharmacokinetics , 1995.
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Description of Research Expertise

Development, validation and implementation of neurodegenerative diseases biomarkers in cerebrospinal fluid and plasma into treatment trials and clinical studies (eg, ADNI study; UPENN ADRC; PPMI study). These studies include the use of manual and highly automated immunoassays and for amyloid beta(1-42), U-p53AZ and for total tau the use of high sensitivity UPLC/tandem mass spectrometry. Multi-modal statistical analyses of these study data to address several questions including the diagnostic utilities of these biomarkers; assessments of the longitudinal trajectories of these biomarkers in AD, MCI and cognitively normal controls to assess the neuropathological changes over time in these individuals.

Selected Publications

Hampel H, Shaw LM, Aisen P, Chen C, Lleo A, Iwatsubo T, Iwata A, Yamada M, Ikeuchi T, Jia J, Wang H, Teunissen CE, Peskind E, Blennow K, Cummings J, Vergallo A.: State-of-the-Art of lumbar puncture and its place in the journey of patients with Alzheimer’s disease. Alzheimer’s and Dementia. 18: 159 - 177 2022.

Li Y, Schindler SE, Bollinger JG, Ovod V, Mawuenyega KG, Weiner MW, Shaw LM, Masters CL, Fowler CJ, Trojanowski JQ, Korecka M, Martins RN, Janelidze S, Hansson O, Bateman RJ. : Validation of Plasma Amyloid-β42/40 for Detecting Alzheimer Disease Amyloid Plaques Neurology. 98: e688 - e699, 2022 Notes: DOI: 10.1212/WNL.0000000000013211.

Dalaby C, Teunissen CE, Blennow K, Alcolea D, Arisi I, Amar EB, …Shaw LM,…Lehman S. : Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer’s disease: an international overview. Alzheimer’s and Dementia. 2022 Notes: DOI: 10.1002/alz.12545.

Libiger O, Shaw LM, Watson MH, Nairn AC, Umana KL, Biarnes MC, Canet-Aviles RM, Jack CR Jr, Breton YA, Cortes L, Chelsky D, Spellman DS, Baker SA, Raghavan N, Potter WZ, Alzheimer's Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium, Longitudinal CSF Proteomics Project Team.: Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer's disease. Alzheimer's & Dementia. 17 (12): 1976 - 87, 2021

Karikari TK, Benedet AL, Ashton NJ, Lantero Rodriguez J, Snellman A, Suarez-Calvet M, Saha-Chaudhuri P, Lussier F, Kvartsberg H, Rial AM, Pascoal TA, Andreasson U, Scholl M, Weiner MW, Rosa-Neto P, Trojanowski JQ, Shaw LM, Blennow K, Zetterberg H, Alzheimer's Disease Neuroimaging Initiative.: Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative. Molecular Psychiatry. 26 (2) : 429 - 442, 2021

Cousins KAQ, Phillips JS, Irwin DJ, Lee EB, Wolk DA, Shaw LM, Zetterberg H, Blennow K, Burke SE, Kinney NG, Gibbons GS, McMillan CT, Trojanowski JQ, Grossman M.: ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration. Alzheimer's & Dementia. 17 (5): 822 - 30, 2021

Moon S, Kim S, Mankhong S, Choi SH, Vandijck M, Kostanjevecki V, Jeong JH, Yoon SJ, Park KW, Kim EJ, Yoon B, Kim HJ, Jang JW, Hong JY, Park DH, Shaw LM, Kang JH.: Alzheimer's cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans : CSF AD biomarkers measured by Lumipulse in Koreans. Alzheimer's Research & Therapy. 13 (1) : 22, 2021

Shaw LM, Iseli TA, Wiesenfeld D, Ramakrishnan A, Granger CL.: Postoperative pulmonary complications following major head and neck cancer surgery. International Journal of Oral & Maxillofacial Surgery. 50 (3) : 302 - 8, Mar 2021.

Howard E, Irwin DJ, Rascovsky K, Nevler N, Shellikeri S, Tropea TF, Spindler M, Deik A, Chen-Plotkin A, Siderowf A, Dahodwala N, Weintraub D, Shaw LM, Trojanowski JQ, Vaishnavi SN, Wolk DA, Mechanic-Hamilton D, Morley JF, Duda JE, Grossman M, Cousins KAQ.: Cognitive Profile and Markers of Alzheimer Disease-Type Pathology in Patients With Lewy Body Dementias. Neurology. 96 (14): e1855 - e1864, 04 06 2021.

Parjane N, Cho S, Ash S, Cousins KAQ, Shellikeri S, Liberman M, Shaw LM, Irwin DJ, Grossman M, Nevler N.: Digital Speech Analysis in Progressive Supranuclear Palsy and Corticobasal Syndromes. Journal of Alzheimer's Disease. 82 (1) : 33 - 45 2021.

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Last updated: 03/02/2022
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