Dr. Cuchel is interested in the study of mechanisms regulating the metabolism of lipid and lipoproteins, using two parallel approaches: animal models and well-defined human monogenic disorders. She is also interested in early phase development of novel therapeutic strategies for the treatment of rare genetic disorders of lipid metabolism and for the enhancement of reverse cholesterol transport.
Vitali C, Rader DJ, Cuchel M.: Novel therapeutic opportunities for familial lecithin:cholesterol acyltransferase deficiency: promises and challenges. Curr Opin Lipidol Dec 2022.
Tromp TR, Cuchel M.: New algorithms for treating homozygous familial hypercholesterolemia. Curr Opin Lipidol 33: 326-335, Dec 2022.
Bajaj A, Cuchel M.: From supravalvular to valvular aortic stenosis: are statins contributing to the phenotypic shift in homozygous familial hypercholesterolaemia? Eur Heart J 43: 3240-3242, Sep 2022.
Bajaj A, Cuchel M.: Advancements in the Treatment of Homozygous Familial Hypercholesterolemia. J Atheroscler Thromb Apr 2022.
Vitali C, Bajaj A, Nguyen C, Schnall J, Chen J, Stylianou K, Rader DJ, Cuchel M.: A systematic review of the natural history and biomarkers of primary Lecithin:Cholesterol Acyltransferase (LCAT) deficiency. J Lipid Res Jan 2022.
Tromp TR, Hartgers ML, Hovingh GK, Vallejo-Vaz AJ, Ray KK, Soran H, Freiberger T, Bertolini S, Harada-Shiba M, Blom DJ, Raal FJ, Cuchel M; Homozygous Familial Hypercholesterolaemia International Clinical Collaborators.: Worldwide experience of homozygous familial hypercholesterolaemia: retrospective cohort study. Lancet 399: 719-728, Jan 2022.
Zanotti I, Potì F, Cuchel M.: HDL and reverse cholesterol transport in humans and animals: Lessons from pre-clinical models and clinical studies. Biochim Biophys Acta Mol Cell Biol Lipids 2022.
Hancock-Cerutti W, Millar JS, Valentini S, Liu J, Billheimer JT, Rader DJ, Cuchel M.: Assessing HDL Metabolism in Subjects with Elevated Levels of HDL Cholesterol and Coronary Artery Disease. Molecules 26: 6862, Nov 2021.
Cuchel M, McGowan MP.: Familial hypercholesterolaemia: too many lost opportunities. Lancet 398: 1667-1668, Nov 2021.
Ajufo E, deGoma EM, Raper A, Yu KD, Cuchel M, Rader DJ.: A randomized controlled trial of genetic testing and cascade screening in familial hypercholesterolemia. Genet Med May 2021.
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Last updated: 12/09/2022
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