Symposium Program
| Wednesday, July 17, 2024 | |
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| Registration | |
| Breakfast | |
| Welcome and Introductions to Britton Chance Mitchell D. Schnall, MD, PhD Senior Vice President for Data and Technology and Eugene P. Pendergrass Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| Keynote Lecture "NIBIB and the Technology Legacy of Britton Chance” Bruce Tromberg, PhD Director, National Institute of Biomedical Imaging and Bioengineering |
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| Focus Topic Session: Novel Technologies and Applications | |
| “Imaging cerebral blood flow in humans during brain activation tasks using laser speckle contrast imaging” David Boas, PhD Professor, Biomedical Engineering, Boston University |
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| "Non‐invasive assessment of glymphatic flux with near‐infrared spectroscopy" Research Fellow, Mitchell Robinson, BS, PhD Arthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School |
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| "Detection of abnormalities in the post‐acute COVID brain using functional and frequency domain near‐infrared spectroscopy" Damilola Adingupu, PhD The University of Calgary |
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| “Metabolic Nanoscopy for Studying Aging and Diseases” Lingyan Shi, PhD Associate Professor, Shu Chien-Gene Lay Department of Bioengineering, UC San Diego |
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| Coffee Break and Informal Exchange | |
| Focus Topic Session: Cancer | |
| "Oxygen imaging in radiation therapy: deciphering the mechanism of the FLASH effect" Sergei Vinogradov, PhD Professor of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania |
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| “New radionuclide diagnostics and therapeutics for oncology” Charles Henry Manning, PhD Professor of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center |
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| “Biologic confirmation of the effectiveness of spin‐lattice relaxation based electron paramagnetic resonance location of tumor hypoxia in mammalian tumors for local radiation boosts” Howard Halpern, MD, PhD Professor of Radiation and Cellular Oncology, University of Chicago |
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| "Early Detection of Pancreatic Cancer by Hyperpolarized Magnetic Resonance" Jose Enriquez, PhD Candidate The University of Texas MD Anderson Cancer Center |
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| "Integration of Whole Brain Spectroscopic Imaging in Planning Workflow for Personalized Delivery of TTFields in Glioblastomas" Sanjeev Chawla, PhD, DABMP Research Assistant Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| Flash Highlights of Individual Posters | |
| Lunch, Poster Viewing, Junior/Senior Researcher Exchange | |
| Focus Topic Session: Mitochondrial Function and Redox Metabolism | |
| “A mitochondrial etiology of neuropsychiatric and metabolic diseases” Douglas Wallace, PhD Professor and Director of Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia |
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| "Mitochondrial redox activities in the human brain at rest and under NIR light stimulation in vivo measured with broadband NIRS" Hanli Liu, PhD Professor of Bioengineering, University of Texas at Arlington, Bioengineering |
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| "Diffuse Optical Monitoring of Cytochrome C Oxidase and Hemodynamics during Drug‐Induced Mitochondrial Dysfunction in Swine" Alistair Lewis, MS PhD Candidate, University of Pennsylvania |
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| "Probing in vivo redox biochemistry using hyperpolarized magnetic resonance" Kayvan R. Keshari, PhD Professor of Radiology, Memorial Sloan Kettering Cancer Center |
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| Coffee Break and Informal Exchange | |
| Keynote Lecture “Label‐free, two‐photon imaging of metabolic and mitochondrial function in living tissues” Irene Georgakoudi, PhD Professor of Biomedical Engineering, Tufts University |
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| Focus Topic Session: Mitochondrial Function and Redox Metabolism | |
| "Optical redox imaging of postmortem human brain tissue for deep pathological characterization of neurodegenerative tauopathies" He N. Xu, PhD Assistant Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| “In vivo measurement of regional NAD indices in human brain by phosphorus magnetic resonance spectroscopic imaging at 1.5 Tesla” Fernando Arias‐Mendoza, MD, PhD Senior Principal Scientist, Advanced Imaging Research, Inc. and Adjunct Associate Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| "In vivo cerebral NAD+ measures by downfield 1H MRS following acute oral nicotinamide riboside supplementation" Ravi Nanga, PhD Research Assistant Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| Coffee Break and Informal Exchange | |
| Panel‐Reflections on Dr. Britton Chance's Life & Legacy Arjun Yodh, PhD | David Boas, PhD | Hanli Liu, PhD | Helmut Sies, MD | Henry Forman, PhD | Bruce Rosen, MD, PhD | Ting Li, PhD | Ravi Reddy, PhD | Ilias Tachtsidis, PhD |
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| Networking Reception | |
| Thursday, July 18, 2024 | |
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| Registration | |
| Breakfast | |
| Keynote Lecture “Molecular imaging and theranostics of cancer” Zaver M. Bhujwalla, PhD Professor & Vice-Chair, Department of Radiology; Johns Hopkins University School of Medicine |
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| Focus Topic Session: Cancer | |
| “Glutamine metabolism in breast cancer: Insights and a few surprises provided by molecular imaging” David A. Mankoff, MD, PhD Professor and Vice-Chair for Radiology Research, Perelman School of Medicine at the University of Pennsylvania Contributions made by Rong Zhou, PhD Research Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| “Quantifying tissue metabolism & response to acute therapies with radiation beams” Brian Pogue, PhD Professor & Chair, Dept of Medical Physics, University of Wisconsin-Madison |
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| "Compression‐induced hemodynamic imaging markers for the prediction of pathological outcomes in breast cancer patients treated with neoadjuvant chemotherapy" Bin Deng, PhD Arthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School |
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| "An organismal perspective on the Warburg effect" Neil Blackstone, PhD Department of Biological Sciences, Northern Illinois University |
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| Coffee Break and Informal Exchange | |
| Focus Topic Session: Brain/CNS | |
| "Advancing deuterium (2H) MRSI technology for quantitative imaging and study of human brain glucose metabolism and metabolic reprogramming under healthy and diseased state" Wei Chen, PhD Professor of Radiology and Biomedical Engineering, University of Minnesota |
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| “Assessing cerebrovascular insufficiency and neural risk with diffuse optical methods” Maria Angela Franceschini, PhD Professor of Radiology, Massachusetts General Hospital, Harvard Medical School |
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| “Diffuse optical monitoring of cerebral oxygen metabolism in pediatric hydrocephalus” Wesley Baker, PhD Assistant Professor of Neurology, Children's Hospital of Philadelphia |
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| "Therapeutic Application of Photobiomodulation for Multiple Concussions" Denis Bragin, PhD Lovelace Biomedical Research Institute, University of New Mexico School of Medicine |
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| "Longitudinal Evolution of Capillary Stalling in Post‐Ischemia Stroke Penumbra" Rockwell Tang, BS Neurophotonics Center, Department of Biomedical Engineering, Boston University |
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| Flash Highlights of Individual Posters | |
| Lunch, Poster Viewing, Junior/Senior Researcher Exchange | |
| Focus Topic Session: Novel Technologies/Applications | |
| "Advanced Neuromonitoring in Neonates with Critical Congenital Heart Disease: Insights from Diffuse Optical Technologies" Jennifer Lynch, MD, PhD |
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| "Bedside Monitoring of Cortical Hemodynamics in Pediatric ECMO Patients Using High‐Density Diffuse Optical Tomography" Sophia McMorrow, BS Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis |
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| "Near‐infrared fluorescence detection for assessment of aspiration risk" Goro Nishimura, PhD Hokkaido University, Sapporo, Japan |
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| "Predicting Blood Pressure Changes Using FlexNIRS during Carotid Endarterectomy" Zahra Einalou, PhD Research Fellow, Arthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School |
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| "Continuous Blood Pressure Monitoring using forehead PPG (FlexNIRS) and Deep Learning" John Sunwoo, PhD Research Fellow, Arthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School |
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| "Monitoring brain and muscle physiology by NIRS in vivo: brain performance enhancement at high altitude and therapeutic effects of cupping therapy" Ting Li, PhD Professor, Biomedical Engineering Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, China |
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| Coffee Break and Informal Exchange | |
| Focus Topic Session: Cancer | |
| "Catching melanomas misdiagnosed as “early stage” using pump‐probe microscopy ” Warren S. Warren, PhD Professor of Chemistry, Duke University |
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| "Tissue optical properties correction of multispectral singlet oxygen luminescent dosimetry (MSOLD) for BPD‐mediated Photodynamic Therapy" Weibing Yang, PhD Postdoctoral Research, Perelman School of Medicine at the University of Pennsylvania |
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| “Metabolic modulation towards improved outcome in cancer therapy” Kavindra Nath, PhD Assistant Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| “How to effectively use measurements of oxygen in tissue for preclinical and clinical studies using EPR” Harold Swartz, MD, PhD Professor of Radiology and Medicine (Radiation Oncology), Dartmouth College |
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| Coffee Break and Informal Exchange | |
| Panel‐Research Innovation and Clinical Translations Brian Pogue, PhD | Robert Alfano, PhD | Zaver Bhujwalla, PhD | Wei Chen, PhD | Joel Karp, PhD | David Mankoff, MD, PhD |
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| Networking Reception | |
| Friday, July 19, 2024 | |
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| Registration | |
| Breakfast | |
| Keynote Lecture "Deuterium metabolic imaging – past, present and future” Robin A. de Graaf, PhD Professor of Radiology and Biomedical Imaging, Yale University |
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| Focus Topic Session: Novel Technologies and Applications | |
| “Chemical exchange weighted MRI: Technical developments and biomedical applications” Ravinder Reddy, PhD Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| "50 years of EPR Oximetry: From Capillary to Clinic" Periannan Kuppusamy, PhD Professor of Radiology, Dartmouth Geisel School of Medicine |
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| "Using Computationally Optimized Multi‐Dimensional Field Sequences to Improve SABRE Hyperpolarization" Shannon Eriksson, MD, PhD Massachusetts General Hospital Department of Anesthesia, Critical Care & Pain Medicine |
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| "Femtosecond Optical Kerr Effect in Tissues as a New Optical Biopsy Method for Cancer Detection" Sandra Mamani, BS, EE PhD Candidate, The Grove School of Engineering at City College CUNY |
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| Coffee Break and Informal Exchange | |
| Focus Topic Session: Brain and CNS | |
| “Non- and minimally invasive monitoring of brain and spinal cord hemodynamics with diffuse optics” David R. Busch, PhD Assistant Professor, University of Texas Southwestern Medical Center |
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| “Hyperspectral near‐infrared spectroscopy for monitoring cerebral blood oxygenation and metabolism” Mamadou Diop, PhD Assistant Professor of Medical Biophysics, Western University, Canada |
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| "Towards beat‐to‐beat intracranial pressure estimation a depth‐enhanced 1064nm interferometric diffuse correlation spectroscopy system" Marco Renna, PhD Research Fellow, Arthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School |
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| "Novel Method for Extraction of Default Mode Network and Dorsal Attention Network using fNIRS" Laura Carlton, BME Neurophotonics Center, Biomedical Engineering, Boston University |
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| "MW FlexNIRS 2.0 Wearable, low‐cost, LED‐based, multi‐wavelength NIRS oximeter for cytochrome c oxidase recovery in neonates" Nikola Otic, BME Research Fellow, Arthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School |
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| Flash Highlights of Individual Posters (III) | |
| Lunch, Poster Viewing, Junior/Senior Researcher Exchange | |
| Focus Topic Session: Mitochondrial Function and Redox Metabolism | |
| “Developing novel metabolic imaging methodologies to improve primary mitochondrial disease mechanistic understanding in zebrafish and disease severity in patients” Marni J. Falk, MD Professor and Executive Director, Mitochondrial Medicine Frontier Program, Children's Hospital of Philadelphia |
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| “Imaging oxidative phosphorylation and gluconeogenesis with hyperpolarized 13C probes: Clinical applications and recent advances” Jae Mo Park, PhD Associate Professor of Biomedical Engineering and Radiology, UT Southwestern Medical Center |
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| "Assessing mitochondria in disease and chronic injury using NIRS" Kevin McCully, PhD Professor of Kinesiology, University of Georgia |
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| "Imaging NAD redox states ex vivo and in vivo" Lin Z. Li, PhD Research Associate Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| Coffee Break and Informal Exchange | |
| Focus Topic Session: Cancer | |
| “Clinical pi‐MRSI techniques to detect prognostic markers of immunotherapy in cancer patients” Qiuhong He, PhD Associate Professor of Bioengineering, School of Health Sciences, College of Human and Health Sciences, Purdue University |
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| “Recent development and application of hyperpolarized 13C metabolic imaging methods for oncology and cardiovascular diseases” Terence Gade, MD, PhD Associate Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| “Translating optical molecular imaging for fluorescence guided surgery of non‐small cell lung cancer” E. James Delikatny, PhD Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| Coffee Break and Informal Exchange | |
| Panel‐Career Development and Grant Opportunities David Mankoff, MD, PhD | Janet Eary, MD (NCI) | Paul Barrett, PhD (NIA) |
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| Free Evening | |
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Saturday, July 20, 2024 |
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| Registration | |
| Breakfast | |
| Keynote Lecture "Total‐body metabolic imaging with PET" Simon R. Cherry, PhD Professor Emeritus, Department of Biomedical Engineering and Radiology, University of California |
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| Focus Topic Session: Nuclear/Isotopic Imaging Technologies | |
| “Measuring the role of reactive oxygen species as a key mediator of neurodegeneration in vivo with PET.” Robert Mach, PhD Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania |
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| "Evaluate FDG‐PET volumetric metrics for quantifying disease burden and predicting tumor recurrence in percutaneous liver malignancy ablation." Fereshteh Yazdanpanah, MD, HMBA Postdoctoral Research Fellow, Perelman School of Medicine at the University of Pennsylvania |
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| "Positronium Lifetime Imaging – a New Metabolic Imaging Modality Enabled by Long Axial Field of View Positron Emission Tomography Scanners" Bing Dai, PhD Senior Research Investigator, Perelman School of Medicine at the University of Pennsylvania |
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| "Spatiomics of atherosclerotic plaques in hyperlipidemic mice" Robin Joshi, PhD Senior Research Investigator, Perelman School of Medicine at the University of Pennsylvania |
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| Coffee Break and Informal Exchange | |
| Focus Topic Session: Novel Technologies & Applications | |
| “Imaging cellular metabolism with stimulated Raman scattering” Yihui Shen, PhD Assistant Professor of Bioengineering, Perelman School of Medicine at the University of Pennsylvania |
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| “Dynamic contrast optical coherence tomography imaging of 3D organoids for studying developmental biology” Chao Zhou, PhD Professor of Biomedical Engineering, Washington University at St. Louis |
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| "Development of a novel genetically encoded hyperpolarized MRI reporter for in vivo cell tracking" Molly Sheehan, PhD Senior Research Investigator, Department of Radiology, University of Pennsylvania |
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| "Higher-altitude training significantly enhances behavioral performance and EEG activation in optical lobe: a Stroop Test study" Xiang Ji, PhD Presented by: Bowen Zhang, PhD Candidate Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China |
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| "Detection of Pressure Injuries using Subcutaneous Blood Flow by Diffuse Correlation Spectroscopy" Randolph Sinahon, BS PhD Candidate, School of Biomedical Engineering at Drexel University |
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| "Functional Diffuse Optical Monitoring of Placenta and Brain: Recent Results" Arjun Yodh, PhD James M. Skinner Professor of Science and Chair, Department of Physics and Astronomy, University of Pennsylvania |
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| Poster Awards & Final Remarks | |
| Lunch | |