James Alwine
Contact Info
421 Curie Boulevard
756 BRB II/III
Philadelphia PA, 19104-6160
Education
B.S. (Chemistry) Elizabethtown College, 1969
Ph.D. (Biological Chemistry) The Milton S. Hershey Medical Center of the Pennsylvania State University, 1974
Links
Career
Dr. Alwine’s 37 year career at Penn has covered many aspects of molecular virology including the effects of viruses on cellular transcription, mRNA processing, stress responses, metabolism and the relationship of these effects to the genesis or propagation of cancer. He has made numerous significant contributions for which he was elected Fellow of the American Academy of Microbiology, and Fellow of the American Association for the Advancement of Science. His recent research interests have been in the area of defining the microbiome of the tumor microenvironment, data that may provide diagnostic and prognostic biomarkers.
Dr. Alwine became Emeritus in 2016 and no longer runs a research laboratory. However, he remains active as a department member and mentor/advisor to anyone who asks.
Selected Publications
1. Banerjee S, Tian T, Wei Z, Peck KN, Shih N, Chalian AA, O'Malley Jr BW, Weinstein GS, Feldman MD, Alwine JC, Robertson ES. Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas. Scientific Reports. 2017 (in press)
2. Banerjee S, Tian T, Wei Z, Shih N, Feldman MD, Coukos G, Alwine JC, Robertson ES. The ovarian cancer oncobiome. Oncotarget. 2017 Mar 30. doi: 10.18632/oncotarget.16717.
3. Vysochan A, Sengupta A, Weljie AM, Alwine JC, Yu Y. ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1528-E1535. doi: 10.1073/pnas.1614268114.
4. Banerjee S, Peck KN, Feldman MD, Schuster MG, Alwine JC, Robertson ES. Identification of fungal pathogens in a patient with acute myelogenic leukemia using a pathogen detection array technology. Cancer Biol Ther. 2016 Apr 2;17(4):339-45. doi: 10.1080/15384047.2015.1121349.
5. Banerjee S, Wei Z, Tan F, Peck KN, Shih N, Feldman M, Rebbeck TR, Alwine JC, Robertson ES. Distinct microbiological signatures associated with triple negative breast cancer. Sci Rep. 2015 Oct 15;5:15162. doi: 10.1038/srep15162.
6. Baldwin DA, Feldman M, Alwine JC, Robertson ES. Metagenomic assay for identification of microbial pathogens in tumor tissues. MBio. 2014 Sep 16;5(5):e01714-14. doi: 10.1128/mBio.01714-14.
7. Yu Y, Maguire TG, Alwine JC. ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1951-6. doi: 10.1073/pnas.1310779111.
8. Shenk T, Alwine JC. Human Cytomegalovirus: Coordinating Cellular Stress, Signaling, and Metabolic Pathways. Annu Rev Virol. 2014 Nov;1(1):355-74. doi: 10.1146/annurev-virology-031413-085425.
Lab Personnel
Ashley Hughes - Administrative Assistant