Perelman School of Medicine at the University of Pennsylvania

Penn Rhinology Lab


Dynamic regulation of ciliary beat frequency and pathogenic ciliary alterations in disease states

Motile cilia line the airways and through organized beating are responsible for continuously clearing respiratory secretions toward the glottis. The rate at which cilia beat is dynamic and regulated by myriad factors, such as mucus viscosity and particulate debris. Thus, dynamic modulation of ciliary beat frequency is critical for maintaining clean airways. Our studies on the cellular processes governing the dynamic regulation of cilia beat frequency and the clinically relevant factors (infectious and inflammatory mediators) that disrupt this homeostatic process have demonstrated that inflammatory mediators associated with chronic rhinosinusitis disrupt the dynamic ciliary response, yielding an ineffective mucociliary clearance apparatus.



Selected Publications:

  1. Workman AD, Cohen NA. The effect of drugs and other compounds on the ciliary beat frequency of human respiratory epithelium.Am J Rhinol Allergy. 2014 Nov-Dec;28(6):454-64. doi: 10.2500/ajra.2014.28.4092. Review. PubMed PMID: 25514481.
  2. Lee RJ, Chen B, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Cohen NA. Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion. FASEB J. 2013 Dec;27(12):5094-103. doi: 10.1096/fj.13-234476. Epub 2013 Aug 9. PubMed PMID: 23934280.
  3. Zhao KQ, Cowan AT, Lee RJ, Goldstein N, Droguett K, Chen B, Zheng C, Villalon M, Palmer JN, Kreindler JL, Cohen NA.Molecular modulation of airway epithelial ciliary response to sneezing. FASEB J. 2012 Aug;26(8):3178-87. doi: 10.1096/fj.11-202184. Epub 2012 Apr 18. PubMed PMID: 22516297.
  4. Gudis D, Zhao KQ, Cohen NA. Acquired cilia dysfunction in chronic rhinosinusitis. Am J Rhinol Allergy. 2012 Jan-Feb;26(1):1-6. doi: 10.2500/ajra.2012.26.3716. Review. PubMed PMID: 22391065; PubMed Central PMCID: PMC3906518.