Perelman School of Medicine at the University of Pennsylvania

Penn Rhinology Lab

Topical Therapies

Topical therapies in chronic rhinosinusitis

Traditional management of chronic rhinosinusitis has utilized systemic anti-infective and anti-inflammatory therapies. We were the first to establish an animal model to evaluate topical therapies for the management of rhinosinusitis and significantly helped drive a paradigm shift toward topical therapies. Additionally, we introduced the concept of using topical surfactants for mobilizing inspissated secretions and demonstrated safety of topical steroid douching. 

topical therapies


Selected Publications:

  1. Wei CC, Adappa ND, Cohen NA. Use of topical nasal therapies in the management of chronic rhinosinusitis. Laryngoscope. 2013 Oct;123(10):2347-59. doi: 10.1002/lary.24066. Epub 2013 Apr 1. Review. PubMed PMID: 23553558.
  2. Chiu AG, Chen B, Palmer JN, O'Malley BW Jr, Cohen NA. Safety evaluation of sinus surfactant solution on respiratory cilia function. Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):280-3. doi: 10.1002/alr.20018. Epub 2011 Jun 6. PubMed PMID: 22287432.
  3. Chiu AG, Palmer JN, Woodworth BA, Doghramji L, Cohen MB, Prince A, Cohen NA. Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient. Am J Rhinol. 2008 Jan-Feb;22(1):34-7. doi: 10.2500/ajr.2008.22.3122. PubMed PMID: 18284857.
  4. Chiu AG, Antunes MB, Palmer JN, Cohen NA. Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilms. J Antimicrob Chemother. 2007 Jun;59(6):1130-4. Epub 2007 Apr 3. PubMed PMID: 17405780.
  5. Chiu AG, Antunes MB, Feldman M, Cohen NA. An animal model for the study of topical medications in sinusitis. Am J Rhinol. 2007 Jan-Feb;21(1):5-9. PubMed PMID: 17283553.