Perelman School of Medicine at the University of Pennsylvania

Penn Rhinology Lab


  1. Cohen NA. The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis. Laryngoscope. 2016 Sep 21. doi: 10.1002/lary.26198. PubMed PMID: 27650657.
  2. Cottrill EE, Chen B, Adappa ND, Palmer JN, Kennedy DW, Lee RJ, Cohen NA. Expression of dermcidin in human sinonasal secretions. Int Forum Allergy Rhinol. 2016 Sep 21. doi: 10.1002/alr.21851. PubMed PMID: 27650261.
  3. Lee RJ, Workman AD, Carey RM, Chen B, Rosen PL, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Cohen NA. Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function. Sci Rep. 2016 Sep 14;6:33221. doi: 10.1038/srep33221. PubMed PMID: 27623953
  4. Hariri BM, Cohen NA. New insights into upper airway innate immunity. Am J Rhinol Allergy. 2016 Sep;30(5):319-23. doi: 10.2500/ajra.2016.30.4360. PubMed PMID: 27657896.
  5. Carey RM, Chen B, Adappa ND, Palmer JN, Kennedy DW, Lee RJ, Cohen NA. Human upper airway epithelium produces nitric oxide in response to Staphylococcus epidermidis. Int Forum Allergy Rhinol. 2016 Aug 10. doi: 10.1002/alr.21837. PubMed PMID: 27509402.
  6. Carey RM, Adappa ND, Palmer JN, Lee RJ, Cohen NA. Taste Receptors: Regulators of Sinonasal Innate Immunity. Laryngoscope Investigative Otolaryngology. 2016 June 28. doi: 10.1002/lio2.26
  7. Adappa ND, Truesdale CM, Workman AD, Doghramji L, Mansfield C, Kennedy DW, Palmer JN, Cowart BJ, Cohen NA. Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients. Int Forum Allergy Rhinol. 2016 Jun 16. doi: 10.1002/alr.21803. PubMed PMID: 27309535.
  8. Schwartz JS, Tajudeen BA, Cohen NA. Medical management of chronic rhinosinusitis - an update. Expert Rev Clin Pharmacol. 2016 May;9(5):695-704. doi: 10.1586/17512433.2016.1150780. Epub 2016 Feb 29. PubMed PMID: 26849215.
  9. Adappa ND, Workman AD, Hadjiliadis D, Dorgan DJ, Frame D, Brooks S, Doghramji L, Palmer JN, Mansfield C, Reed DR, Cohen NA. T2R38 genotype is correlated with sinonasal quality of life in homozygous ΔF508 cystic fibrosis patients. Int Forum Allergy Rhinol. 2016 Apr;6(4):356-61. doi: 10.1002/alr.21675. Epub 2015 Dec 17. PubMed PMID: 26678226
  10. Zhao K, Craig JR, Cohen NA, Adappa ND, Khalili S, Palmer JN. Sinus irrigations before and after surgery-Visualization through computational fluid dynamics simulations. Laryngoscope. 2016 Mar;126(3):E90-6. doi: 10.1002/lary.25666. Epub 2015 Oct 15. PubMed PMID: 26467934.
  11. Douglas JE, Saunders CJ, Reed DR, Cohen NA. A role for airway taste receptor modulation in the treatment of upper respiratory infections. Expert Rev Respir Med. 2016 Feb;10(2):157-70. doi: 10.1586/17476348.2016.1135742. Epub 2016 Jan 22. PubMed PMID: 26731661; PubMed Central PMCID: PMC4830394.
  12. Orlandi RR, Kingdom TT, Hwang PH, Smith TL, Alt JA, Baroody FM, Batra PS, Bernal-Sprekelsen M, Bhattacharyya N, Chandra RK, Chiu A, Citardi MJ, Cohen NA, DelGaudio J, Desrosiers M, Dhong HJ, Douglas R, Ferguson B, Fokkens WJ, Georgalas C, Goldberg A, Gosepath J, Hamilos DL, Han JK, Harvey R, Hellings P, Hopkins C, Jankowski R, Javer AR, Kern R, Kountakis S, Kowalski ML, Lane A, Lanza DC, Lebowitz R, Lee HM, Lin SY, Lund V, Luong A, Mann W, Marple BF, McMains KC, Metson R, Naclerio R, Nayak JV, Otori N, Palmer JN, Parikh SR, Passali D, Peters A, Piccirillo J, Poetker DM, Psaltis AJ, Ramadan HH, Ramakrishnan VR, Riechelmann H, Roh HJ, Rudmik L, Sacks R, Schlosser RJ, Senior BA, Sindwani R, Stankiewicz JA, Stewart M, Tan BK, Toskala E, Voegels R, Wang de Y, Weitzel EK, Wise S, Woodworth BA, Wormald PJ, Wright ED, Zhou B, Kennedy DW.International Consensus Statement on Allergy and Rhinology: Rhinosinusitis. Int Forum Allergy Rhinol. 2016 Feb;6 Suppl 1:S22-209. doi: 10.1002/alr.21695. PubMed PMID: 26889651.
  13. Lee RJ, Cohen NA. Bitter taste bodyguards. Sci Am. 2016 Feb;314(2):38-43. PubMed PMID: 26930826.
  14. Adappa ND, Farquhar D, Palmer JN, Kennedy DW, Doghramji L, Morris SA, Owens D, Mansfield C, Lysenko A, Lee RJ, Cowart BJ, Reed DR, Cohen NA. TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. Int Forum Allergy Rhinol. 2016 Jan;6(1):25-33. doi: 10.1002/alr.21666. Epub 2015 Nov 12. PubMed PMID: 26562612; PubMed Central PMCID: PMC4830631.
  15. Workman AD, Palmer JN, Adappa ND, Cohen NA. The Role of Bitter and Sweet Taste Receptors in Upper Airway Immunity. Curr Allergy Asthma Rep. 2015 Dec;15(12):72. doi: 10.1007/s11882-015-0571-8. Review. PubMed PMID: 26492878; PubMed Central PMCID: PMC4830640.
  16. Stevens WW, Lee RJ, Schleimer RP, Cohen NA. Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol. 2015 Dec;136(6):1442-53. doi: 10.1016/j.jaci.2015.10.009. Review. PubMed PMID: 26654193; PubMed Central PMCID: PMC4680986.
  17. Carey RM, Workman AD, Chen B, Adappa ND, Palmer JN, Kennedy DW, Lee RJ, Cohen NA. Staphylococcus aureus triggers nitric oxide production in human upper airway epithelium. Int Forum Allergy Rhinol. 2015 Sep;5(9):808-13. doi: 10.1002/alr.21568. Epub 2015 Jun 22. PubMed PMID: 26097237; PubMed Central PMCID: PMC4829394.
  18. Zhang Z, Adappa ND, Doghramji LJ, Chiu AG, Cohen NA, Palmer JN. Different clinical factors associated with Staphylococcus aureus and Pseudomonas aeruginosa in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2015 Aug;5(8):724-33. doi: 10.1002/alr.21532. Epub 2015 Apr 21. PubMed PMID: 25899601.
  19. Zhang Z, Adappa ND, Chiu AG, Doghramji LJ, Cohen NA, Palmer JN. Biofilm-forming bacteria and quality of life improvement after sinus surgery. Int Forum Allergy Rhinol. 2015 Jul;5(7):643-9. doi: 10.1002/alr.21505. Epub 2015 Mar 12. PubMed PMID: 25763837.
  20. Hatten KM, Palmer JN, Lee RJ, Adappa ND, Kennedy DW, Cohen NA. Corticosteroid use does not alter nasal mucus glucose in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2015 Jun;152(6):1140-4. doi: 10.1177/0194599815577567. Epub 2015 Mar 27. PubMed PMID: 25820586.
  21. Zhang Z, Adappa ND, Lautenbach E, Chiu AG, Doghramji LJ, Cohen NA, Palmer JN. Coagulase-negative Staphylococcus culture in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2015 Mar;5(3):204-13. doi: 10.1002/alr.21439. Epub 2014 Nov 3. PubMed PMID: 25367456; PubMed Central PMCID: PMC4352125.
  22. Lee RJ, Cohen NA. Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis. Curr Opin Allergy Clin Immunol. 2015 Feb;15(1):14-20. doi: 10.1097/ACI.0000000000000120. Review. PubMed PMID: 25304231.
  23. Farquhar DR, Kovatch KJ, Palmer JN, Shofer FS, Adappa ND, Cohen NA. Phenylthiocarbamide taste sensitivity is associated with sinonasal symptoms in healthy adults. Int Forum Allergy Rhinol. 2015 Feb;5(2):111-8. doi: 10.1002/alr.21437. Epub 2014 Dec 22. PubMed PMID: 25532854.
  24. Lee RJ, Cohen NA. Taste receptors in innate immunity. Cell Mol Life Sci. 2015 Jan;72(2):217-36. doi: 10.1007/s00018-014-1736-7. Epub 2014 Oct 17. Review. PubMed PMID: 25323130; PubMed Central PMCID: PMC4286424.
  25. Lee RJ, Cohen NA. Bitter and sweet taste receptors in the respiratory epithelium in health and disease. J Mol Med (Berl). 2014 Dec;92(12):1235-44. doi: 10.1007/s00109-014-1222-6. Epub 2014 Nov 13. Review. PubMed PMID: 25391251; PubMed Central PMCID: PMC4830634.
  26. Kim LY, Cohen NA, Palmer JN, Kennedy DW, Zhang Z, Adappa ND. Bacteriology of inverted papilloma. Rhinology. 2014 Dec;52(4):366-70. doi: 10.4193/Rhin14.007. PubMed PMID: 25479216.
  27. Zhang Z, Adappa ND, Doghramji LJ, Chiu AG, Lautenbach E, Cohen NA, Palmer JN. Quality of life improvement from sinus surgery in chronic rhinosinusitis patients with asthma and nasal polyps. Int Forum Allergy Rhinol. 2014 Nov;4(11):885-92. doi: 10.1002/alr.21406. Epub 2014 Sep 25. PubMed PMID: 25256422.
  28. Workman AD, Cohen NA. The effect of drugs and other compounds on the ciliary beat frequency of human respiratory epithelium.Am J Rhinol Allergy. 2014 Nov-Dec;28(6):454-64. doi: 10.2500/ajra.2014.28.4092. Review. PubMed PMID: 25514481.
  29. Peters AT, Spector S, Hsu J, Hamilos DL, Baroody FM, Chandra RK, Grammer LC, Kennedy DW, Cohen NA, Kaliner MA, Wald ER, Karagianis A, Slavin RG; Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology. Diagnosis and management of rhinosinusitis: a practice parameter update. Ann Allergy Asthma Immunol. 2014 Oct;113(4):347-85. doi: 10.1016/j.anai.2014.07.025. PubMed PMID: 25256029.
  30. Lee RJ, Cohen NA. Sinonasal solitary chemosensory cells "taste" the upper respiratory environment to regulate innate immunity.Am J Rhinol Allergy. 2014 Sep-Oct;28(5):366-73. doi: 10.2500/ajra.2014.28.4077. Review. PubMed PMID: 25198020.
  31. Xiong G, Elkind JA, Kundu S, Smith CJ, Antunes MB, Tamashiro E, Kofonow JM, Mitala CM, Cole J, Stein SC, Grady MS, Einhorn E, Cohen NA, Cohen AS. Traumatic brain injury-induced ependymal ciliary loss decreases cerebral spinal fluid flow. J Neurotrauma. 2014 Aug 15;31(16):1396-404. doi: 10.1089/neu.2013.3110. Epub 2014 Jun 20. Erratum in: J Neurotrauma. 2015 Feb 15;32(4):287. Cole, Jeffrey [added]. PubMed PMID: 24749541; PubMed Central PMCID: PMC4132584.
  32. Lee RJ, Chen B, Redding KM, Margolskee RF, Cohen NA. Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components. Innate Immun. 2014 Aug;20(6):606-17. doi: 10.1177/1753425913503386. Epub 2013 Sep 17. PubMed PMID: 24045336; PubMed Central PMCID: PMC4811369.
  33. Zhang Z, Palmer JN, Morales KH, Howland TJ, Doghramji LJ, Adappa ND, Chiu AG, Cohen NA, Lautenbach E. Culture-inappropriate antibiotic therapy decreases quality of life improvement after sinus surgery. Int Forum Allergy Rhinol. 2014 May;4(5):403-10. doi: 10.1002/alr.21277. Epub 2014 Jan 10. PubMed PMID: 24415647; PubMed Central PMCID: PMC4004654.
  34. Lai Y, Dilidaer D, Chen B, Xu G, Shi J, Lee RJ, Cohen NA. In vitro studies of a distillate of rectified essential oils on sinonasal components of mucociliary clearance. Am J Rhinol Allergy. 2014 May-Jun;28(3):244-8. doi: 10.2500/ajra.2014.28.4036. PubMed PMID: 24980236.
  35. Zhang Z, Adappa ND, Lautenbach E, Chiu AG, Doghramji L, Howland TJ, Cohen NA, Palmer JN. The effect of diabetes mellitus on chronic rhinosinusitis and sinus surgery outcome. Int Forum Allergy Rhinol. 2014 Apr;4(4):315-20. doi: 10.1002/alr.21269. Epub 2014 Jan 10. PubMed PMID: 24415555; PubMed Central PMCID: PMC3975697.
  36. Lee RJ, Kofonow JM, Rosen PL, Siebert AP, Chen B, Doghramji L, Xiong G, Adappa ND, Palmer JN, Kennedy DW, Kreindler JL, Margolskee RF, Cohen NA. Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest. 2014 Mar;124(3):1393-405. doi: 10.1172/JCI72094. Epub 2014 Feb 17. PubMed PMID: 24531552; PubMed Central PMCID: PMC3934184.
  37. Uz U, Chen B, Palmer JN, Cingi C, Unlu H, Cohen NA. Effects of thymoquinone and montelukast on sinonasal ciliary beat frequency. Am J Rhinol Allergy. 2014 Mar-Apr;28(2):122-5. doi: 10.2500/ajra.2014.28.4010. PubMed PMID: 24717949.
  38. Adappa ND, Zhang Z, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Scott T, Zhao NW, Owens D, Lee RJ, Cohen NA. The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. Int Forum Allergy Rhinol. 2014 Jan;4(1):3-7. doi: 10.1002/alr.21253. Epub 2013 Dec 2. PubMed PMID: 24302675; PubMed Central PMCID: PMC4082560.
  39. Adams KM, Abraham V, Spielman D, Kolls JK, Rubenstein RC, Conner GE, Cohen NA, Kreindler JL. IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells. PLoS One. 2014 Aug 20;9(8):e103263. doi: 10.1371/journal.pone.0103263. eCollection 2014. PubMed PMID: 25141009; PubMed Central PMCID: PMC4139276.
  40. Lee RJ, Chen B, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Cohen NA. Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion. FASEB J. 2013 Dec;27(12):5094-103. doi: 10.1096/fj.13-234476. Epub 2013 Aug 9. PubMed PMID: 23934280.
  41. Wei CC, Adappa ND, Cohen NA. Use of topical nasal therapies in the management of chronic rhinosinusitis. Laryngoscope. 2013 Oct;123(10):2347-59. doi: 10.1002/lary.24066. Epub 2013 Apr 1. Review. PubMed PMID: 23553558.
  42. Lee RJ, Cohen NA. The emerging role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis.Am J Rhinol Allergy. 2013 Jul-Aug;27(4):283-6. doi: 10.2500/ajra.2013.27.3911. Review. PubMed PMID: 23883809.
  43. DePoortere D, Chen B, Cohen NA. Polyhydrated ionogen with MgBr2 accelerates in vitro respiratory epithelial healing. Am J Rhinol Allergy. 2013 Jul-Aug;27(4):333-7. doi: 10.2500/ajra.2013.25.3910. PubMed PMID: 23883817.
  44. Rosen PL, Palmer JN, O'Malley BW Jr, Cohen NA. Surfactants in the management of rhinopathologies. Am J Rhinol Allergy. 2013 May-Jun;27(3):177-80. doi: 10.2500/ajra.2013.27.3873. Review. PubMed PMID: 23710951; PubMed Central PMCID: PMC3901440.
  45. Adappa ND, Howland TJ, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Lee RJ, Cohen NA. Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention. Int Forum Allergy Rhinol. 2013 Mar;3(3):184-7. doi: 10.1002/alr.21140. Epub 2013 Jan 16. PubMed PMID: 23322450.
  46. Bleier BS, Palmer JN, Cohen NA. Evaluation of a polysaccharide gel for laser-assisted skull base repair. Am J Rhinol Allergy. 2013 Mar-Apr;27(2):148-50. doi: 10.2500/ajra.2013.27.3885. PubMed PMID: 23562206.
  47. Antunes MB, Chi JJ, Liu Z, Goldstein-Daruech N, Palmer JN, Zhu J, Cohen NA. Molecular basis of tobacco-induced bacterial biofilms: an in vitro study. Otolaryngol Head Neck Surg. 2012 Nov;147(5):876-84. doi: 10.1177/0194599812447263. Epub 2012 May 17. PubMed PMID: 22597576.
  48. Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, Jiang P, Abraham V, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Beauchamp GK, Doulias PT, Ischiropoulos H, Kreindler JL, Reed DR, Cohen NA. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest. 2012 Nov;122(11):4145-59. doi: 10.1172/JCI64240. Epub 2012 Oct 8. PubMed PMID: 23041624; PubMed Central PMCID: PMC3484455.
  49. Kreindler JL, Chen B, Kreitman Y, Kofonow J, Adams KM, Cohen NA. The novel dry extract BNO 1011 stimulates chloride transport and ciliary beat frequency in human respiratory epithelial cultures. Am J Rhinol Allergy. 2012 Nov-Dec;26(6):439-43. doi: 10.2500/ajra.2012.26.3821. PubMed PMID: 23232192.
  50. De Poortere DA, De Poortere BM, Cohen NA. Nasal tip angiolipoma: the "Pinocchio" nasal deformity. Ear Nose Throat J. 2012 Oct;91(10):E1-4. PubMed PMID: 23076855.
  51. Xiong G, Zhang L, Mojsilovic-Petrovic J, Arroyo E, Elkind J, Kundu S, Johnson B, Smith CJ, Cohen NA, Grady SM, Cohen AS.GABA and glutamate are not colocalized in mossy fiber terminals of developing rodent hippocampus. Brain Res. 2012 Sep 20;1474:40-9. doi: 10.1016/j.brainres.2012.07.042. Epub 2012 Jul 27. PubMed PMID: 22842523; PubMed Central PMCID: PMC3695404.
  52. Zhao KQ, Cowan AT, Lee RJ, Goldstein N, Droguett K, Chen B, Zheng C, Villalon M, Palmer JN, Kreindler JL, Cohen NA.Molecular modulation of airway epithelial ciliary response to sneezing. FASEB J. 2012 Aug;26(8):3178-87. doi: 10.1096/fj.11-202184. Epub 2012 Apr 18. PubMed PMID: 22516297.
  53. Shen JC, Cope E, Chen B, Leid JG, Cohen NA. Regulation of murine sinonasal cilia function by microbial secreted factors. Int Forum Allergy Rhinol. 2012 Mar-Apr;2(2):104-10. doi: 10.1002/alr.21002. Epub 2012 Jan 17. PubMed PMID: 22253045.
  54. Bloom JD, Bleier BS, Goldstein SA, Carniol PJ, Palmer JN, Cohen NA. Laser facial nerve welding in a rabbit model. Arch Facial Plast Surg. 2012 Jan-Feb;14(1):52-8. doi: 10.1001/archfacial.2011.61. Epub 2011 Aug 15. PubMed PMID: 21844481.
  55. Zhao KQ, Xiong G, Wilber M, Cohen NA, Kreindler JL. A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L4-L12. doi: 10.1152/ajplung.00102.2011. Epub 2011 Sep 30. PubMed PMID: 21964404; PubMed Central PMCID: PMC3349375.
  56. Shen JC, Chen B, Cohen NA. Keratinocyte chemoattractant (interleukin-8) regulation of sinonasal cilia function in a murine model.Int Forum Allergy Rhinol. 2012 Jan-Feb;2(1):75-9. doi: 10.1002/alr.20087. Epub 2011 Aug 18. PubMed PMID: 22311845.
  57. Gudis D, Zhao KQ, Cohen NA. Acquired cilia dysfunction in chronic rhinosinusitis. Am J Rhinol Allergy. 2012 Jan-Feb;26(1):1-6. doi: 10.2500/ajra.2012.26.3716. Review. PubMed PMID: 22391065; PubMed Central PMCID: PMC3906518.
  58. Lai Y, Chen B, Shi J, Palmer JN, Kennedy DW, Cohen NA. Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2011 Dec;128(6):1207-1215.e1. doi: 10.1016/j.jaci.2011.09.001. Epub 2011 Oct 7. PubMed PMID: 21982113.
  59. Kofonow JM, Bhuskute A, Doghramji L, Palmer JN, Cohen NA, Chiu AG. One-way valve bottle contamination rates in the immediate post-functional endoscopic sinus surgery period. Am J Rhinol Allergy. 2011 Nov-Dec;25(6):393-6. doi: 10.2500/ajra.2011.25.3664. PubMed PMID: 22185742.
  60. Cheng G, Wang LC, Fridlender ZG, Cheng GS, Chen B, Mangalmurti NS, Saloura V, Yu Z, Kapoor V, Mozdzanowska K, Moon E, Sun J, Kreindler JL, Cohen NA, Caton AJ, Erikson J, Albelda SM. Pharmacologic activation of the innate immune system to prevent respiratory viral infections. Am J Respir Cell Mol Biol. 2011 Sep;45(3):480-8. doi: 10.1165/rcmb.2010-0288OC. Epub 2010 Dec 10. PubMed PMID: 21148741; PubMed Central PMCID: PMC3265219.
  61. DePoortere D, Kofonow JM, Chen B, Chiu AG, Cohen NA. Murine ciliotoxicity and rabbit sinus mucosal healing by polyhydrated ionogen. Otolaryngol Head Neck Surg. 2011 Sep;145(3):482-8. PubMed PMID: 21493328.
  62. Zhang Z, Linkin DR, Finkelman BS, O'Malley BW Jr, Thaler ER, Doghramji L, Kennedy DW, Cohen NA, Palmer JN. Asthma and biofilm-forming bacteria are independently associated with revision sinus surgeries for chronic rhinosinusitis. J Allergy Clin Immunol. 2011 Jul;128(1):221-223.e1. doi: 10.1016/j.jaci.2011.02.022. Epub 2011 Mar 24. PubMed PMID: 21439623.
  63. Zhao KQ, Goldstein N, Yang H, Cowan AT, Chen B, Zheng C, Palmer JN, Kreindler JL, Cohen NA. Inherent differences in nasal and tracheal ciliary function in response to Pseudomonas aeruginosa challenge. Am J Rhinol Allergy. 2011 Jul-Aug;25(4):209-13. doi: 10.2500/ajra.2011.25.3614. PubMed PMID: 21819755.
  64. Chiu AG, Chen B, Palmer JN, O'Malley BW Jr, Cohen NA. Safety evaluation of sinus surfactant solution on respiratory cilia function. Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):280-3. doi: 10.1002/alr.20018. Epub 2011 Jun 6. PubMed PMID: 22287432.
  65. Zhang Z, Kofonow JM, Finkelman BS, Doghramji L, Chiu AG, Kennedy DW, Cohen NA, Palmer JN. Clinical factors associated with bacterial biofilm formation in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2011 Mar;144(3):457-62. doi: 10.1177/0194599810394302. Epub 2011 Feb 3. PubMed PMID: 21493213.
  66. DePoortere D, Kofonow JM, Chiu AG, Cohen NA. Polyhydrated ionogen enhances postoperative sinonasal ciliated remucosalization. Int Forum Allergy Rhinol. 2011 Mar-Apr;1(2):83-7. doi: 10.1002/alr.20019. PubMed PMID: 22287324.
  67. Phillips PS, Sacks R, Marcells GN, Cohen NA, Harvey RJ. Nasal nitric oxide and sinonasal disease: a systematic review of published evidence. Otolaryngol Head Neck Surg. 2011 Feb;144(2):159-69. Review. PubMed PMID: 21634057.
  68. Goldstein-Daruech N, Cope EK, Zhao KQ, Vukovic K, Kofonow JM, Doghramji L, González B, Chiu AG, Kennedy DW, Palmer JN, Leid JG, Kreindler JL, Cohen NA. Tobacco smoke mediated induction of sinonasal microbial biofilms. PLoS One. 2011 Jan 6;6(1):e15700. doi: 10.1371/journal.pone.0015700. PubMed PMID: 21253587; PubMed Central PMCID: PMC3017060.
  69. Cope EK, Goldstein-Daruech N, Kofonow JM, Christensen L, McDermott B, Monroy F, Palmer JN, Chiu AG, Shirtliff ME, Cohen NA, Leid JG. Regulation of virulence gene expression resulting from Streptococcus pneumoniae and nontypeable Haemophilus influenzae interactions in chronic disease. PLoS One. 2011;6(12):e28523. doi: 10.1371/journal.pone.0028523. Epub 2011 Dec 5. PubMed PMID: 22162775; PubMed Central PMCID: PMC3230614.
  70. Bleier BS, Cohen NM, Bloom JD, Palmer JN, Cohen NA. Laser tissue welding in lung and tracheobronchial repair: an animal model. Chest. 2010 Aug;138(2):345-9. doi: 10.1378/chest.09-2721. Epub 2010 Mar 18. PubMed PMID: 20299627.
  71. Cohen NA, Antunes MB, Morgenstern KE. Prevention and management of lacrimal duct injury. Otolaryngol Clin North Am. 2010 Aug;43(4):781-8. doi: 10.1016/j.otc.2010.04.005. PubMed PMID: 20599082.
  72. Gudis DA, Cohen NA. Cilia dysfunction. Otolaryngol Clin North Am. 2010 Jun;43(3):461-72, vii. doi: 10.1016/j.otc.2010.02.007. Review. PubMed PMID: 20525503. 
  73. Bleier BS, Cohen NA, Chiu AG, O'Malley BW Jr, Doghramji L, Palmer JN. Endonasal laser tissue welding: first human experience.Am J Rhinol Allergy. 2010 May-Jun;24(3):244-6. doi: 10.2500/ajra.2010.24.3463. PubMed PMID: 20537294.
  74. Bleier BS, Kofonow JM, Hashmi N, Chennupati SK, Cohen NA. Antibiotic eluting chitosan glycerophosphate implant in the setting of acute bacterial sinusitis: a rabbit model. Am J Rhinol Allergy. 2010 Mar-Apr;24(2):129-32. doi: 10.2500/ajra.2010.24.3439. PubMed PMID: 20338111.
  75. Suh JD, Cohen NA, Palmer JN. Biofilms in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2010 Feb;18(1):27-31. doi: 10.1097/MOO.0b013e328334f670. Review. PubMed PMID: 19940770.
  76. Woodworth BA, Zhang S, Tamashiro E, Bhargave G, Palmer JN, Cohen NA. Zinc increases ciliary beat frequency in a calcium-dependent manner. Am J Rhinol Allergy. 2010 Jan-Feb;24(1):6-10. doi: 10.2500/ajra.2010.24.3379. PubMed PMID: 20109308.
  77. Savitski AN, Mesaros C, Blair IA, Cohen NA, Kreindler JL. Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells. Respir Res. 2009 Nov 27;10:120. doi: 10.1186/1465-9921-10-120. PubMed PMID: 19943936; PubMed Central PMCID: PMC2792224.
  78. Cohen NA, Zhang S, Sharp DB, Tamashiro E, Chen B, Sorscher EJ, Woodworth BA. Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency. Laryngoscope. 2009 Nov;119(11):2269-74. doi: 10.1002/lary.20223. PubMed PMID: 19418539.
  79. Antunes MB, Gudis DA, Cohen NA. Epithelium, cilia, and mucus: their importance in chronic rhinosinusitis. Immunol Allergy Clin North Am. 2009 Nov;29(4):631-43. doi: 10.1016/j.iac.2009.07.004. Review. PubMed PMID: 19879439.
  80. Tamashiro E, Banks CA, Chen B, Gudis DA, Dogrhamji L, Myntti M, Medina J, Chiu AG, Cohen NA. In vivo effects of citric acid/zwitterionic surfactant cleansing solution on rabbit sinus mucosa. Am J Rhinol Allergy. 2009 Nov-Dec;23(6):597-601. doi: 10.2500/ajra.2009.23.3398. PubMed PMID: 19958609.
  81. Tamashiro E, Cohen NA, Palmer JN, Lima WT. Effects of cigarette smoking on the respiratory epithelium and its role in the pathogenesis of chronic rhinosinusitis. Braz J Otorhinolaryngol. 2009 Nov-Dec;75(6):903-7. Review. PubMed PMID: 20209295.
  82. Hekiert AM, Kofonow JM, Doghramji L, Kennedy DW, Chiu AG, Palmer JN, Leid JG, Cohen NA. Biofilms correlate with TH1 inflammation in the sinonasal tissue of patients with chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2009 Oct;141(4):448-53. doi: 10.1016/j.otohns.2009.06.090. PubMed PMID: 19786211.
  83. Welch KC, Cohen MB, Doghramji LL, Cohen NA, Chandra RK, Palmer JN, Chiu AG. Clinical correlation between irrigation bottle contamination and clinical outcomes in post-functional endoscopic sinus surgery patients. Am J Rhinol Allergy. 2009 Jul-Aug;23(4):401-4. doi: 10.2500/ajra.2009.23.3338. PubMed PMID: 19671255.
  84. Tamashiro E, Antunes MB, Palmer JN, Cohen NA, Anselmo-Lima WT. Implications of bacterial biofilms in chronic rhinosinusitis.Braz J Infect Dis. 2009 Jun;13(3):232-5. Review. PubMed PMID: 20191203.
  85. Cohen M, Kofonow J, Nayak JV, Palmer JN, Chiu AG, Leid JG, Cohen NA. Biofilms in chronic rhinosinusitis: a review. Am J Rhinol Allergy. 2009 May-Jun;23(3):255-60. doi: 10.2500/ajra.2009.23.3319. Review. PubMed PMID: 19490797.
  86. Tamashiro E, Xiong G, Anselmo-Lima WT, Kreindler JL, Palmer JN, Cohen NA. Cigarette smoke exposure impairs respiratory epithelial ciliogenesis. Am J Rhinol Allergy. 2009 Mar-Apr;23(2):117-22. doi: 10.2500/ajra.2009.23.3280. PubMed PMID: 19401033.
  87. Zhang S, Fortenberry JA, Cohen NA, Sorscher EJ, Woodworth BA. Comparison of vectorial ion transport in primary murine airway and human sinonasal air-liquid interface cultures, models for studies of cystic fibrosis, and other airway diseases. Am J Rhinol Allergy. 2009 Mar-Apr;23(2):149-52. doi: 10.2500/ajra.2009.23.3285. PubMed PMID: 19401039.
  88. Chennupati SK, Chiu AG, Tamashiro E, Banks CA, Cohen MB, Bleier BS, Kofonow JM, Tam E, Cohen NA. Effects of an LL-37-derived antimicrobial peptide in an animal model of biofilm Pseudomonas sinusitis. Am J Rhinol Allergy. 2009 Jan-Feb;23(1):46-51. doi: 10.2500/ajra.2009.23.3261. PubMed PMID: 19379612.
  89. Bleier BS, Paulson DP, O'Malley BW, Li D, Palmer JN, Chiu AG, Cohen NA. Chitosan glycerophosphate-based semirigid dexamethasone eluting biodegradable stent. Am J Rhinol Allergy. 2009 Jan-Feb;23(1):76-9. doi: 10.2500/ajra.2009.23.3268. PubMed PMID: 19379617.
  90. Khalid AN, Woodworth BA, Prince A, Quraishi SA, Antunes MB, Long FH, Bolger WE, Chiu AG, Palmer JN, Cohen NA. Physiologic alterations in the murine model after nasal fungal antigenic exposure. Otolaryngol Head Neck Surg. 2008 Nov;139(5):695-701. doi: 10.1016/j.otohns.2008.07.018. PubMed PMID: 18984266.
  91. Bleier BS, Gratton MA, Leibowitz JM, Palmer JN, Newman JG, Cohen NA. Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: an animal model. Otolaryngol Head Neck Surg. 2008 Nov;139(5):713-7. doi: 10.1016/j.otohns.2008.08.006. PubMed PMID: 18984269.
  92. Bleier BS, Palmer JN, Gratton MA, Cohen NA. In vivo laser tissue welding in the rabbit maxillary sinus. Am J Rhinol. 2008 Nov-Dec;22(6):625-8. doi: 10.2500/ajr.2008.22.3244. PubMed PMID: 19178803.
  93. Lai SY, Ziober AF, Lee MN, Cohen NA, Falls EM, Ziober BL. Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma. Oral Oncol. 2008 Jul;44(7):683-8. Epub 2007 Nov 9. PubMed PMID: 17996485.
  94. Woodworth BA, Prince A, Chiu AG, Cohen NA, Schlosser RJ, Bolger WE, Kennedy DW, Palmer JN. Spontaneous CSF leaks: a paradigm for definitive repair and management of intracranial hypertension. Otolaryngol Head Neck Surg. 2008 Jun;138(6):715-20. doi: 10.1016/j.otohns.2008.02.010. PubMed PMID: 18503841.
  95. Woodworth BA, Tamashiro E, Bhargave G, Cohen NA, Palmer JN. An in vitro model of Pseudomonas aeruginosa biofilms on viable airway epithelial cell monolayers. Am J Rhinol. 2008 May-Jun;22(3):235-8. doi: 10.2500/ajr.2008.22.3178. PubMed PMID: 18588754.
  96. Prince AA, Steiger JD, Khalid AN, Dogrhamji L, Reger C, Eau Claire S, Chiu AG, Kennedy DW, Palmer JN, Cohen NA. Prevalence of biofilm-forming bacteria in chronic rhinosinusitis. Am J Rhinol. 2008 May-Jun;22(3):239-45. doi: 10.2500/ajr.2008.22.3180. PubMed PMID: 18588755.
  97. Erickson VR, Antunes M, Chen B, Cohen NA, Hwang PH. The effects of retinoic acid on ciliary function of regenerated sinus mucosa. Am J Rhinol. 2008 May-Jun;22(3):334-6. doi: 10.2500/ajr.2008.22.3176. PubMed PMID: 18588770.
  98. Bhargave G, Woodworth BA, Xiong G, Wolfe SG, Antunes MB, Cohen NA. Transient receptor potential vanilloid type 4 channel expression in chronic rhinosinusitis. Am J Rhinol. 2008 Jan-Feb;22(1):7-12. doi: 10.2500/ajr.2008.22.3125. PubMed PMID: 18284852.
  99.  Chiu AG, Palmer JN, Woodworth BA, Doghramji L, Cohen MB, Prince A, Cohen NA. Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient. Am J Rhinol. 2008 Jan-Feb;22(1):34-7. doi: 10.2500/ajr.2008.22.3122. PubMed PMID: 18284857.
  100.  Chennupati SK, Woodworth BA, Palmer JN, Cohen NA, Kennedy DW, Chiu AG. Intraoperative IGS/CT updates for complex endoscopic frontal sinus surgery. ORL J Otorhinolaryngol Relat Spec. 2008;70(4):268-70. doi: 10.1159/000133653. Epub 2008 May 19. PubMed PMID: 18487904.
  101. Bleier BS, Palmer JN, Sparano AM, Cohen NA. Laser-assisted cerebrospinal fluid leak repair: an animal model to test feasibility.Otolaryngol Head Neck Surg. 2007 Nov;137(5):810-4. PubMed PMID: 17967651.
  102. Woodworth BA, Antunes MB, Bhargave G, Palmer JN, Cohen NA. Murine tracheal and nasal septal epithelium for air-liquid interface cultures: a comparative study. Am J Rhinol. 2007 Sep-Oct;21(5):533-7. PubMed PMID: 17999784.
  103. Woodworth BA, Bhargave GA, Palmer JN, Chiu AG, Cohen NA, Lanza DC, Bolger WE, Kennedy DW. Clinical outcomes of endoscopic and endoscopic-assisted resection of inverted papillomas: a 15-year experience. Am J Rhinol. 2007 Sep-Oct;21(5):591-600. Erratum in: Am J Rhinol. 2008 Jan-Feb;22(1):97. PubMed PMID: 17999796.
  104. Antunes MB, Woodworth BA, Bhargave G, Xiong G, Aguilar JL, Ratner AJ, Kreindler JL, Rubenstein RC, Cohen NA. Murine nasal septa for respiratory epithelial air-liquid interface cultures. Biotechniques. 2007 Aug;43(2):195-6, 198, 200 passim. PubMed PMID: 17824387.
  105. Woodworth BA, Wood R, Bhargave G, Cohen NA, Baatz JE, Schlosser RJ. Surfactant protein B detection and gene expression in chronic rhinosinusitis. Laryngoscope. 2007 Jul;117(7):1296-301. PubMed PMID: 17507829.
  106. Antunes MB, Feldman MD, Cohen NA, Chiu AG. Dose-dependent effects of topical tobramycin in an animal model of Pseudomonas sinusitis. Am J Rhinol. 2007 Jul-Aug;21(4):423-7. PubMed PMID: 17882910.
  107. Chiu AG, Antunes MB, Palmer JN, Cohen NA. Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilms. J Antimicrob Chemother. 2007 Jun;59(6):1130-4. Epub 2007 Apr 3. PubMed PMID: 17405780.
  108. Cohen MA, Cohen NA, Moonis G, Kennedy DW. Long-term follow-up of a multiloculated arachnoid cyst of the middle cranial fossa.Ear Nose Throat J. 2007 Jun;86(6):338-41. PubMed PMID: 17703811.
  109. Chen B, Antunes MB, Claire SE, Palmer JN, Chiu AG, Kennedy DW, Cohen NA. Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction. Am J Rhinol. 2007 May-Jun;21(3):346-53. PubMed PMID: 17621822.
  110. Antunes MB, Cohen NA. Mucociliary clearance--a critical upper airway host defense mechanism and methods of assessment. Curr Opin Allergy Clin Immunol. 2007 Feb;7(1):5-10. Review. PubMed PMID: 17218804.
  111. Chiu AG, Antunes MB, Feldman M, Cohen NA. An animal model for the study of topical medications in sinusitis. Am J Rhinol. 2007 Jan-Feb;21(1):5-9. PubMed PMID: 17283553.
  112. Cohen NA. Sinonasal mucociliary clearance in health and disease. Ann Otol Rhinol Laryngol Suppl. 2006 Sep;196:20-6. Review. PubMed PMID: 17040014.
  113. Cohen NA, Kennedy DW. Revision endoscopic sinus surgery. Otolaryngol Clin North Am. 2006 Jun;39(3):417-35, vii. Review. PubMed PMID: 16757223.
  114. Chen B, Shaari J, Claire SE, Palmer JN, Chiu AG, Kennedy DW, Cohen NA. Altered sinonasal ciliary dynamics in chronic rhinosinusitis. Am J Rhinol. 2006 May-Jun;20(3):325-9. PubMed PMID: 16871938.
  115. Cohen NA, Widelitz JS, Chiu AG, Palmer JN, Kennedy DW. Familial aggregation of sinonasal polyps correlates with severity of disease. Otolaryngol Head Neck Surg. 2006 Apr;134(4):601-4. PubMed PMID: 16564380.
  116. Shaari J, Palmer JN, Chiu AG, Judy KD, Cohen AS, Kennedy DW, Cohen NA. Regional analysis of sinonasal ciliary beat frequency. Am J Rhinol. 2006 Mar-Apr;20(2):150-4. PubMed PMID: 16686377.
  117. Schipor I, Palmer JN, Cohen AS, Cohen NA. Quantification of ciliary beat frequency in sinonasal epithelial cells using differential interference contrast microscopy and high-speed digital video imaging. Am J Rhinol. 2006 Jan-Feb;20(1):124-7. PubMed PMID: 16539308.
  118. Monin DL, Blumner K, Cohen NA, Brooks JS, Chen C, Kennedy DW. Endoscopic resection of a venous hemangioma of the optic nerve sheath. Ear Nose Throat J. 2005 Sep;84(9):586, 588, 590 passim. PubMed PMID: 16261759.
  119. Hockstein NG, Cohen NA, Palmer JN. Proteolysis of beta-trace Protein? Otolaryngol Head Neck Surg. 2005 Aug;133(2):310; author reply 310-1. PubMed PMID: 16087036.
  120. Chiu AG, Schipor I, Cohen NA, Kennedy DW, Palmer JN. Surgical decisions in the management of frontal sinus osteomas. Am J Rhinol. 2005 Mar-Apr;19(2):191-7. PubMed PMID: 15921220.
  121. Cohen NA, Kennedy DW. Endoscopic sinus surgery: where we are-and where we're going. Curr Opin Otolaryngol Head Neck Surg. 2005 Feb;13(1):32-8. Review. PubMed PMID: 15654213.