Perelman School of Medicine at the University of Pennsylvania

Clinical Cell and Vaccine Production Facility (CVPF)

prep room

Publications - HIV

T cell adoptive immunity for cancer | Gene-modified T cells for HIV | Dendritic cell vaccines for cancer | Reviews

Publication PMID PMCID
Tebas, P, Stein, D, Tang, WW, Frank, I, Wang, SQ, Lee, G, Spratt, SK, Surosky, RT, Giedlin, MA, Nichol, G, Holmes, MC, Gregory, PD, Ando, DA, Kalos, M, Collman, RG, Binder-Scholl, G, Plesa, G, Hwang, W-T, Levine, BL, June, CH. Gene Editing of CCR5 in Autologous CD4 T-cells of Persons Infected with HIV. N Engl J Med. 2014 Mar 6;370(10):901-10. DOI: 10.1056/NEJMoa1300662. Notes: In Press. 24597865 PMC4084652
Wang GP, Levine BL, Binder GK, Berry CC, Malani N, McGarrity G, Tebas P, June CH, Bushman FD. Analysis of Lentiviral Vector Integration in HIV+ Study Subjects Receiving Autologous Infusions of Gene Modified CD4+ T Cells. Mol Ther. 2009 May;17(5):844-50. DOI: 10.1038/mt.2009.16. Epub 2009 Mar 3. 19259065 PMC2835137
Yu JJ, Wu TL, Liszewski MK, Dai J, Swiggard WJ, Baytop C, Frank I, Levine BL, Yang W, Theodosopoulos T, O'Doherty U. A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients. Virology. 2008 Sep 15;379(1):78-86. DOI: 10.1016/j.virol.2008.05.030. Epub 2008 Jul 22. 18649912 PMC2610678
Levine BL, Humeau LM, Boyer J, MacGregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD, Dropulic B, June CH. Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17372-7. DOI: 10.1073/pnas.0608138103. Epub 2006 Nov 7. 17090675 PMC1635018
Bernstein WB, Cox JH, Aronson NE, Tracy L, Schlienger K, Ratto-Kim S, Garner R, Cotte J, Zheng Z, Wineston L, Liebig C, Galley LM, Connor M, Birx DL, Carroll RG, Levine BL. Immune reconstitution following autologous transfers of CD3/CD28 stimulated CD4+ T cells to HIV-infected persons. Clin Immunol. 2004 Jun;111(3):262-74. DOI: 10.1016/j.clim.2004.03.004. 15183147  
Humeau LM, Binder GK, Lu X, Slepushkin V, Merling R, Echeagaray P, Pereira M, Slepushkina T, Barnett S, Dropulic LK, Carroll R, Levine BL, June CH, Dropulic B. Efficient Lentiviral Vector-Mediated Control of HIV-1 Replication in CD4 Lymphocytes from Diverse HIV+ Infected Patients Grouped According to CD4 Count and Viral Load. Mol Ther. 2004 Jun;9(6):902-13. DOI: 10.1016/j.ymthe.2004.03.005. 15194057  
Levine BL, Bernstein WB, Aronson NE, Schlienger K, Cotte J, Peretto S, Humphries MJ, Ratio-Kim S, Birx DL, Steffens C, Landay A, Carroll RG, June CH. Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nat Med. 2002 Jan;8(1):47-53. DOI: 10.1038/nm0102-47. 11786906