Clinical Cell and Vaccine Production Facility (CVPF)

Publications - HIV

T cell adoptive immunity for cancer | Gene-modified T cells for HIV | Dendritic cell vaccines for cancer | Reviews

1. Clinical trial results provide the rationale to protect dual HIV-specific T cells with a signaling-defective HIV fusion inhibitor. Mol Ther. 2026 Jan 10:S1525-0016(26)00006-7. doi: 10.1016/j.ymthe.2026.01.006. Online ahead of print.
2. CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication. J Clin Invest. 2024 May 1;134(9):e181576. doi: 10.1172/JCI181576.
3. CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication.  J Clin Invest. 2021 Apr 1;131(7):e144486. doi: 10.1172/JCI144486.PMID: 33571163 Free PMC article.
4. Autologous CD4 T Lymphocytes Modified with a Tat-Dependent, Virus-Specific Endoribonuclease Gene in HIV-Infected Individuals. Mol Ther. 2021 Feb 3;29(2):626-635. doi: 10.1016/j.ymthe.2020.11.007. Epub 2020 Nov 11. PMID: 33186691
5. Novel gene and cellular therapy approaches for treating HIV.  Discov Med. 2016 Apr;21(116):283-92. PMID: 27232514 Review.
6. T cell engineering as therapy for cancer and HIV: our synthetic future.   Biol Sci. 2015 Oct 19;370(1680):20140374. doi: 10.1098/rstb.2014.0374. PMID: 26416683. Review.
7. Gene Editing of CCR5 in Autologous CD4 T-cells of Persons Infected with HIV. N Engl J Med. 2014 Mar 6;370(10):901-10. DOI: 10.1056/NEJMoa1300662. Notes: In Press. PMID 24597865. PMC4084652
8. Analysis of Lentiviral Vector Integration in HIV+ Study Subjects Receiving Autologous Infusions of Gene Modified CD4+ T Cells. Mol Ther. 2009 May;17(5):844-50. DOI: 10.1038/mt.2009.16. Epub 2009 Mar 3.
9. A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients. Virology. 2008 Sep 15;379(1):78-86. DOI: 10.1016/j.virol.2008.05.030. Epub 2008 Jul 22.
10. Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17372-7. DOI: 10.1073/pnas.0608138103. Epub 2006 Nov 7.
11. Immune reconstitution following autologous transfers of CD3/CD28 stimulated CD4+ T cells to HIV-infected persons. Clin Immunol. 2004 Jun;111(3):262-74. DOI: 10.1016/j.clim.2004.03.004.
12. Efficient Lentiviral Vector-Mediated Control of HIV-1 Replication in CD4 Lymphocytes from Diverse HIV+ Infected Patients Grouped According to CD4 Count and Viral Load. Mol Ther. 2004 Jun;9(6):902-13. DOI: 10.1016/j.ymthe.2004.03.005.
13. Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nat Med. 2002 Jan;8(1):47-53. DOI: 10.1038/nm0102-47.