Publications
Early Career Investigators
Polo-like kinase 1 maintains transcription and chromosomal accessibility during mitosis.
Shen Z, Adams K, Moreno R, F Lera R, Kaufman E, Lang JD, E Burkard M.
Mol Biol Cell. 2025 Oct 1;36(10):ar128. doi: 10.1091/mbc.E25-02-0053. Epub 2025 Aug 13. PMID: 40802284; PMCID: PMC12483329.
Endometrial carcinosarcoma without myoinvasion.
Cucinella G, Zammarrelli WA 3rd, Nasioudis D, Gabrilovich S, Capasso I, Berretta R, Scollo P, Raspagliesi F, Baiocchi G, Barresi G, Pecorino B, Bogani G, Kurnit KC, De Brot L, Lembo A, Maryam S, Fought AJ, McGree ME, Chiantera V, Bosquet JG, Fanfani F, Scambia G, Abu-Rustum NR, Mariani A, Giuntoli R 2nd, Glaser G, Leitao MM Jr.
Int J Gynecol Cancer. 2025 Oct;35(10):101971. doi: 10.1016/j.ijgc.2025.101971. Epub 2025 Jun 16. PMID: 40731228.
Emerging approaches to enhance immune responses in ovarian cancer: 15th biennial Rivkin Center Ovarian Cancer Research Symposium.
Zhang N, Porter RL.
Gynecol Oncol. 2025 Aug 20;201:97-101. doi: 10.1016/j.ygyno.2025.08.013. Epub ahead of print. PMID: 40839958.
Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer.
Nie H, Liao L, Zielinski RJ, Gomez JA, Basi AV, Seeley EH, Tan L, Bilecz AJ, Zhou W, Liu H, Wang C, Wu S, Qi Y, Miyamoto T, Severi F, Goldman AR, Gu S, Sood AK, Jazaeri AA, Drapkin R, Claiborne DT, Zhang N, Lorenzi PL, Burks JK, Lengyel E, Gottlieb E, Zhang R.
Cancer Res. 2025 Sep 15;85(18):3471-3489. doi: 10.1158/0008-5472.CAN-25-0654. PMID: 40658600; PMCID: PMC12314749.
Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer.
Murphy B, Miyamoto T, Manning BS, Mirji G, Ugolini A, Kannan T, Hamada K, Zhu YP, Claiborne DT, Huang L, Zhang R, Nefedova Y, Kossenkov A, Veglia F, Shinde R, Zhang N.
J Exp Med. 2024 Dec 2;221(12):e20231967. doi: 10.1084/jem.20231967. Epub 2024 Nov 21. Erratum in: J Exp Med. 2025 Apr 7;222(4):e2023196702272025c. doi: 10.1084/jem.2023196702272025c. PMID: 39570374; PMCID: PMC11586802.
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis.
Andrews JT, Zhang Z, Prasad GVRK, Huey F, Nazarova EV, Wang J, Ranaraja A, Weinkopff T, Li LX, Mu S, Birrer MJ, Huang SC, Zhang N, Argüello RJ, Philips JA, Mattila JT, Huang L.
Mucosal Immunol. 2024 Oct;17(5):825-842. doi: 10.1016/j.mucimm.2024.05.007. Epub 2024 Jun 4. PMID: 38844208; PMCID: PMC11493682.
Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade.
Nie H, Saini P, Miyamoto T, Liao L, Zielinski RJ, Liu H, Zhou W, Wang C, Murphy B, Towers M, Yang T, Qi Y, Kannan T, Kossenkov A, Tateno H, Claiborne DT, Zhang N, Abdel-Mohsen M, Zhang R.
Nat Commun. 2024 Apr 2;15(1):2853. doi: 10.1038/s41467-024-47069-y. PMID: 38565883; PMCID: PMC10987604.
Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species.
Han J, Gallerand A, Erlich EC, Helmink BA, Mair I, Li X, Eckhouse SR, Dimou FM, Shakhsheer BA, Phelps HM, Chan MM, Mintz RL, Lee DD, Schilling JD, Finlay CM, Allen JE, Jakubzick CV, Else KJ, Onufer EJ, Zhang N, Randolph GJ.
Nat Immunol. 2024 Jan;25(1):155-165. doi: 10.1038/s41590-023-01688-7. Epub 2023 Dec 15. PMID: 38102487; PMCID: PMC10990619.
Beyond BRCA deficiency: Clinical and molecular predictors of survival in patients with BRCA-deficient tubo-ovarian high-grade serous carcinoma.
2276
Zwimpfer TA, Fereday S, Pandey A, Ariyaratne D, Jayawardana MW, Twomey L, Laumont CM, Kennedy CJ, Bolithon A, Meagher NS, Milne K, Hamilton P, Alsop J, Antoniou AC, Au-Yeung G, Beckmann MW, Berrington de Gonzalez A, Bisinotto C, Blome F, Bodelon C, Boros J, Brand AH, Carney ME, Cazorla-Jiménez A, Chiu DS, Christie EL, Chudecka-Głaz A, Coulson P, Cushing-Haugen KL, Cybulski C, Darcy KM, David C, Davidson T, Ekici AB, Elishaev E, Emons J, Engler T, Farrell R, Fischer A, García-Closas M, Gentry-Maharaj A, Ghatage P, Glasspool R, Harter P, Hartkopf AD, Hartmann A, Heikaus S, Hernandez BY, Hettiaratchi A, Heublein S, Huntsman DG, Jimenez-Linan M, Jones ME, Kang E, Kaznowska E, Kluz T, Kommoss FKF, Konecny G, Kruitwagen RFPM, Kwon J, Lambrechts D, Lee CH, Lester J, Leung SCY, Leung Y, Linder A, Lissowska J, Loverix L, Lubiński J, Mateoiu C, McNeish IA, Moubarak M, Nelson GS, Nevins N, Olawaiye AB, Olbrecht S, Orsulic S, Osorio A, Quinn CM, Raj Mohan G, Ray-Coquard I, Rodríguez-Antona C, Roxburgh P, RuebnerM, Salfinger SG, Samra S, Schoemaker MJ, Sinn HP, Sonke GS, Steele L, Stewart CJR, Talhouk A, Tan A, Tarney CM, Taylor SE, Van de Vijver KK, van der Aa MA, Van Gorp T, Van Nieuwenhuysen E, van-Wagensveld L, Wahner-Hendrickson AE, Walter C, Wang C, Welz J, Wentzensen N, Wilkens LR, Winham SJ, Winterhoff B, Anglesio MS, Berchuck A, Candido Dos Reis FJ, Cohen PA, Conrads TP, Crowe P, Doherty JA, Fasching PA, Fortner RT, García MJ, Gayther SA, Goodman MT, Gronwald J, Harris HR, Heitz F, Horlings HM, Karlan BY, Kelemen LE, Maxwell GL, Menon U, Modugno F, Neuhausen SL, Schildkraut JM, Staebler A, Sundfeldt K, Swerdlow AJ, Vergote I, Wu AH, Brenton JD, Pharoah PDP, Pearce CL, Pike MC, Goode EL, Ramus SJ, Köbel M, Nelson BH, DeFazio A, Friedlander ML, Bowtell DDL, Garsed DW.
medRxiv [Preprint]. 2025 Sep 22:2025.09.17.25335919. doi: 10.1101/2025.09.17.25335919. PMID: 41040691; PMCID: PMC12486008.
Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer.
Cerra C, Tancock MRC, Thio N, Koo A, Wong A, J Cowley K, Varshney S, Willis MO, Simpson KJ; Australian Ovarian Cancer Study Group; Bowtell DDL, Sanij E, Christie EL, Pearson RB, Kang J, Chan KT.
Cell Death Discov. 2025 Sep 25;11(1):423. doi: 10.1038/s41420-025-02716-1. PMID: 40998801; PMCID: PMC12462457.
Biology of ovarian cancer: Models, microenvironment, and therapeutics: 15th Biennial Rivkin Center Ovarian Cancer Research Symposium.
Chiappinelli KB, Christie EL, Padmanabhan A.
Gynecol Oncol. 2025 Sep 1;201:160-163. doi: 10.1016/j.ygyno.2025.08.014. Epub ahead of print. PMID: 40896859.
Genome doubling fuels ovarian cancer evolution and immune dysregulation.
Burdett NL, Christie EL.
Nature. 2025 Aug;644(8078):880-881. doi: 10.1038/d41586-025-02059-y. PMID: 40670740.
Immunogenic cryptic peptides dominate the antigenic landscape of ovarian cancer.
Raja R, Mangalaparthi KK, Madugundu AK, Jessen E, Pathangey L, Magtibay P, Butler K, Christie E, Pandey A, Curtis M.
Sci Adv. 2025 Feb 21;11(8):eads7405. doi: 10.1126/sciadv.ads7405. Epub 2025 Feb 19. PMID: 39970218; PMCID: PMC11837991.
Australian Ovarian Cancer Study Group; Bowtell DDL, Christie EL. Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer.
Burdett NL, Willis MO, Pandey A, Twomey L, Alaei S;
Nat Commun. 2024 Jul 18;15(1):6069. doi: 10.1038/s41467-024-50137-y. PMID: 39025846; PMCID: PMC11258338.
PCAWG Evolution and Heterogeneity Working Group; SMC-Het Participants; Wedge DC, Morris QD, Ellrott K, Van Loo P, Boutros PC. Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction.
Salcedo A, Tarabichi M, Buchanan A, Espiritu SMG, Zhang H, Zhu K, Ou Yang TH, Leshchiner I, Anastassiou D, Guan Y, Jang GH, Mootor MFE, Haase K, Deshwar AG, Zou W, Umar I, Dentro S, Wintersinger JA, Chiotti K, Demeulemeester J, Jolly C, Sycza L, Ko M;
Na Biotechnol. 2025 Apr;43(4):581-592. doi: 10.1038/s41587-024-02250-y. Epub 2024 Jun 11. PMID: 38862616; PMCID: PMC11994449.
Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma.
Saner FAM, Takahashi K, Budden T, Pandey A, Ariyaratne D, Zwimpfer TA, Meagher NS, Fereday S, Twomey L, Pishas KI, Hoang T, Bolithon A, Traficante N; Australian Ovarian Cancer Study Group; Alsop K, Christie EL, Kang EY, Nelson GS, Ghatage P, Lee CH, Riggan MJ, Alsop J, Beckmann MW, Boros J, Brand AH, Brooks- Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, El-Bahrawy MA, Elishaev E, Erber R, Gayther SA, Gentry-Maharaj A, Gilks CB, Harnett PR, Harris HR, Hartmann A, Hein A, Hendley J, Hernandez BY, Jakubowska A, Jimenez-Linan M, Jones ME, Kaufmann SH, Kennedy CJ, Kluz T, Koziak JM, Kristjansdottir B, Le ND, Lener M, Lester J, Lubiński J, Mateoiu C, Orsulic S, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Soong TR, Steed H, Sukumvanich P, Talhouk A, Taylor SE, Vierkant RA, Wang C, Widschwendter M, Wilkens LR, Winham SJ, Anglesio MS, Berchuck A, Brenton JD, Campbell I, Cook LS, Doherty JA, Fasching PA, Fortner RT, Goodman MT, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Menon U, Modugno F, Pharoah PDP, Schildkraut JM, Sundfeldt K, Swerdlow AJ, Goode EL, DeFazio A, Köbel M, Ramus SJ, Bowtell DDL, Garsed DW.
Clin Cancer Res. 2024 Aug 15;30(16):3481-3498. doi: 10.1158/1078-0432.CCR-23-3552. PMID: 38837893; PMCID: PMC11325151.
Ovarian cancer health disparities: 15th Biennial Rivkin Center Ovarian Cancer Research Symposium.
Brubaker LW, Merritt MA.
Gynecol Oncol. 2025 Aug 13;201:56-59. doi: 10.1016/j.ygyno.2025.08.011. Epub ahead of print. PMID: 40812119.
A phase II, randomized, double-blind study of the use of rucaparib vs. placebo maintenance therapy in metastatic and recurrent endometrial cancer.
Corr BR, Haggerty A, Gysler SM, Taylor S, Behbakht K, Alldredge J, Lefkowits C, Brubaker LW, Bouts C, Babayan LM, Martin LP, Costello J, Bitler BG, Hu J, Guntupalli SR.
Gynecol Oncol. 2025 Sep;200:58-67. doi: 10.1016/j.ygyno.2025.07.008. Epub 2025 Jul 22. PMID: 40700852; PMCID: PMC12398225.
Small W Jr, Klopp AH. Management of Venous Thrombosis and Pulmonary Embolism During Cervical Brachytherapy.
Brower JV, Russo AL, Bradley KA, Fisher CM, Carlson R, Brubaker LW, Hagen PA, Leaf RK,
Pract Radiat Oncol. 2025 Jun 14:S1879-8500(25)00119-5. doi: 10.1016/j.prro.2025.04.013. Epub ahead of print. PMID: 40523472.
The evolving role of HER2 in gynecologic oncology and clinical trial design: A gynecologic pathologist's perspective.
Ehimiaghe E, Marjon N, Post MD, Corr BR, Brubaker LW, Dimmick H, Ireigbe F, Bitler BG, Guntupalli SR, Behbakht K, Wolsky RJ.
Gynecol Oncol. 2025 Jul;198:55-58. doi: 10.1016/j.ygyno.2025.05.017. Epub 2025 May 24. PMID: 40414143.
Design, Implementation, and Evaluation of a Multidisciplinary Palliative Care Curriculum for Obstetrician Gynecologist Residents.
Brubaker LW, Moroney MR, Thannickal A, Alston MJ, Amory JH, Kumar A, Lefkowits C.
Palliat Med Rep. 2025 Feb 28;6(1):90-97. doi: 10.1089/pmr.2024.0082. PMID: 40171212; PMCID: PMC11959220.
The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma.
Van Kleunen LB, Ahmadian M, Post MD, Wolsky RJ, Rickert C, Jordan KR, Hu J, Richer JK, Brubaker LW, Marjon N, Behbakht K, Sikora MJ, Bitler BG, Clauset A.
Cancer Immunol Res. 2024 Nov 4;12(11):1492-1507. doi: 10.1158/2326-6066.CIR-23-1109. PMID: 39115368; PMCID: PMC11534564.
Polycomb Repressor Complex 1 (PRC1) in ovarian cancer: A scoping literature review.
Floyd J, DeSanto K, Bitler BG, Brubaker LW.
Crit Rev Oncol Hematol. 2024 Oct;202:104456. doi: 10.1016/j.critrevonc.2024.104456. Epub 2024 Jul 19. PMID: 39033867.
Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma.
Iwanaga R, Yamamoto TM, Gomez K, Nguyen LL, Woodruff ER, Post MD, Mikeska RG, Danis E, Danhorn T, Boorgula MP, Mitra SS, Marjon NA, Bitler BG, Brubaker LW.
Cancer Res Commun. 2024 Aug 1;4(8):1919-1932. doi: 10.1158/2767-9764.CRC-24-0027. PMID: 38984891; PMCID: PMC11298703.
Ovarian cancer think tank: An overview of the current status of ovarian cancer screening and recommendations for future directions.
Dexter JM, Brubaker LW, Bitler BG, Goff BA, Menon U, Moore KN, Sundaram KM, Walsh CS, Guntupalli SR, Behbakht K
Gynecol Oncol Rep. 2024 Mar 27;53:101376. doi: 10.1016/j.gore.2024.101376. PMID: 38590930; PMCID: PMC10999790.
Early Ovarian Cancer Detection in the Age of Fallopian Tube Precursors: A Systematic Review.
Greenwood A, Woodruff ER, Nguyen C, Piper C, Clauset A, Brubaker LW, Behbakht K, Bitler BG. Obstet Gynecol. 2024 Mar 1;143(3):e63-e77. doi: 10.1097/AOG.0000000000005496. Epub 2024 Jan 4. PMID: 38176019; PMCID: PMC10922166.
CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR.
Bapat J, Yamamoto TM, Woodruff ER, Qamar L, Mikeska RG, Aird KM, Watson ZL, Brubaker LW, Bitler BG.
Cancer Gene Ther. 2024 Feb;31(2):300-310. doi: 10.1038/s41417-023-00703-1. Epub 2023 Nov 29. PMID: 38030811; PMCID: PMC10874890.
Emerging approaches to enhance immune responses in ovarian cancer: 15th biennial Rivkin Center Ovarian Cancer Research Symposium.
Zhang N, Porter RL. Gynecol Oncol. 2025 Aug 20;201:97-101. doi: 10.1016/j.ygyno.2025.08.013. Epub ahead of print. PMID: 40839958.
Ovarian Cancer Therapy.
Miao D, Matulonis UA, Porter RL.
Cold Spring Harb Perspect Med. 2025 May 19:a038232. doi: 10.1101/cshperspect.a038232. Epub ahead of print. PMID: 40389314.
Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer.
You E, Danaher P, Lu C, Sun S, Zou L, Phillips IE, Rojas AS, Ho NI, Song Y, Raabe MJ, Xu KH, Richieri PM, Li H, Aston N, Porter RL, Patel BK, Nieman LT, Schurman N, Hudson BM, North K, Church SE, Deshpande V, Liss AS, Kim TK, Cui Y, Kim Y, Greenbaum BD, Aryee MJ, Ting DT.
Cell. 2024 Dec 12;187(25):7232-7247.e23. doi: 10.1016/j.cell.2024.09.024. Epub 2024 Oct 8. PMID: 39383862; PMCID: PMC11645244.
CAR memory-like NK cells targeting the membrane proximal domain of mesothelin demonstrate promising activity in ovarian cancer.
Tarannum M, Dinh K, Vergara J, Birch G, Abdulhamid YZ, Kaplan IE, Ay O, Maia A, Beaver O, Sheffer M, Shapiro R, Ali AK, Dong H, Ham JD, Bobilev E, James S, Cameron AB, Nguyen QD, Ganapathy S, Chayawatto C, Koreth J, Paweletz CP, Gokhale PC, Barbie DA, Matulonis UA, Soiffer RJ, Ritz J, Porter RL, Chen J, Romee R.
Sci Adv. 2024 Jul 12;10(28):eadn0881. doi: 10.1126/sciadv.adn0881. Epub 2024 Jul 12. PMID: 38996027; PMCID: PMC11244547.
Leveraging dysregulated tumor metabolism for targeting anticancer bacteria.
Santos A, Wang Z, Bharti R, Dey G, Sangwan N, Baldwin W, Zalavadia A, Myers A, Huffman OG, Lathia JD, Hazen SL, Reizes O, Dwidar M.
Sci Adv. 2025 Jun 13;11(24):eads1630. doi: 10.1126/sciadv.ads1630. Epub 2025 Jun 13. PMID: 40512849; PMCID: PMC12164975.
A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency.
Lu Q, Hitch TCA, Zhou JY, Dwidar M, Sangwan N, Lawrence D, Nolan LS, Espenschied ST, Newhall KP, Han Y, Karell PE, Salazar V, Baldridge MT, Clavel T, Stappenbeck TS.
Science. 2024 Sep 27;385(6716):eadk2536. doi: 10.1126/science.adk2536. Epub 2024 Sep 27. PMID: 39325906; PMCID: PMC12486176.
Microbial assimilatory sulfate reduction-mediated H2S: an overlooked role in Crohn's disease development.
Luo W, Zhao M, Dwidar M, Gao Y, Xiang L, Wu X, Medema MH, Xu S, Li X, Schäfer H, Chen M, Feng R, Zhu Y.
Microbiome. 2024 Aug 16;12(1):152. doi: 10.1186/s40168-024-01873-2. PMID: 39152482; PMCID: PMC11328384.
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
Bharti R, Dey G, Khan D, Myers A, Huffman OG, Saygin C, Braley C, Richards E, Sangwan N, Willard B, Lathia JD, Fox PL, Lin F, Jha BK, Brown JM, Yu JS, Dwidar M, Joehlin-Price A, Vargas R, Michener CM, Longworth MS, Reizes O.
Mol Cancer. 2024 Jun 10;23(1):121. doi: 10.1186/s12943-024-02028-5. PMID: 38853277; PMCID: PMC11163727.
Targeting RAD52 overcomes PARP inhibitor resistance in preclinical Brca2-deficient ovarian cancer model.
Ota Y, Gupta V, Fashemi BE, Akande M, Babu P, Thuthika P, Elizagaray ML, Sun L, Sanders B, Kuroki LM, McCourt CK, Hagemann AR, Hagemann IS, Thaker PH, Mutch DG, Powell MA, Hyrc K, Verma P, Krais J, Bitler BG, Mullen M, Khabele D.
bioRxiv [Preprint]. 2025 Sep 26:2025.09.24.678351. doi: 10.1101/2025.09.24.678351. PMID: 41040355; PMCID: PMC12485677.
State-of-the art in emerging therapeutics for ovarian cancer therapy.
Laniti DD, Verma P.
Gynecol Oncol. 2025 Aug 21;201:109-113. doi: 10.1016/j.ygyno.2025.08.010. Epub ahead of print. PMID: 40845538.
Phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer.
Schab A, Compadre A, Drexler R, Loeb M, Rodriguez K, Brill J, Harrington S, Sandoval C, Sanders B, Kuroki L, McCourt C, Hagemann AR, Thaker P, Mutch D, Powell M, Serra V, Hagemann IS, Walts AE, Karlan BY, Orsulic S, Fuh KC, Sun L, Verma P, Lomonosova E, Zhao P, Khabele D, Mullen MM.
J Clin Invest. 2025 May 20;135(13):e189511. doi: 10.1172/JCI189511. PMID: 40392598; PMCID: PMC12208538.
MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage.
Seppa IM, Ceppi I, Tennakoon M, Reginato G, Jackson J, Rouault CD, Agashe S, Sviderskiy VO, Limbu M, Lantelme E, Meroni A, Braunshier S, Borrello D, Verma P, Cejka P, Vindigni A.
Genes Dev. 2025 May 2;39(9-10):582-602. doi: 10.1101/gad.352421.124. PMID: 40127955; PMCID: PMC12047661.
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers.
Aubuchon LN, Verma P.
DNA Repair (Amst). 2024 Sep;141:103736. doi: 10.1016/j.dnarep.2024.103736. Epub 2024 Jul 31. PMID: 39096699.
Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells.
Ramakrishnan N, Weaver TM, Aubuchon LN, Woldegerima A, Just T, Song K, Vindigni A, Freudenthal BD, Verma P.
Nat Commun. 2024 Jul 27;15(1):6343. doi: 10.1038/s41467-024-50673-7. PMID: 39068174; PMCID: PMC11283519.
A high-content flow cytometry and dual CRISPR-Cas9 based platform to quantify genetic interactions.
Ramakrishnan N, Malachowski T, Verma P. Methods Cell Biol. 2024;182:299-312. doi: 10.1016/bs.mcb.2023.02.005. Epub 2023 Mar 25. PMID: 38359984.
Reduced SPAG17 Expression in Systemic Sclerosis Triggers Myofibroblast Transition and Drives Fibrosis.
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Sapao P, Roberson EDO, Shi B, Assassi S, Skaug B, Lee F, Naba A, Perez White BE, Córdova-Fletes C, Tsou PS, Sawalha AH, Gudjonsson JE, Ma F, Verma P, Bhattacharyya D, Carns M, Strauss JF 3rd, Sicard D, Tschumperlin DJ, Champer MI, Campagnola PJ, Teves ME, Varga J.
J Invest Dermatol. 2023 Feb;143(2):284-293. doi: 10.1016/j.jid.2022.08.052. Epub 2022 Sep 15. PMID: 36116512; PMCID: PMC10097410.
Models, microenvironment, and therapeutics: 15th Biennial Rivkin Center Ovarian Cancer Research Symposium.
Biology of ovarian cancer.
Chiappinelli KB, Christie EL, Padmanabhan A.
Gynecol Oncol. 2025 Sep 1;201:160-163. doi: 10.1016/j.ygyno.2025.08.014. Epub ahead of print. PMID: 40896859.
Research is care: How patients and researchers can work together to bring the bedside back to the bench - a patient advocacy panel discussion: 15th Biennial Rivkin Center Ovarian Cancer Research Symposium.
Soong TR, Islam BN, Hunt K, Nadeem A, Smith J, Curtis M.
Gynecol Oncol. 2025 Aug 22;201:114-117. doi: 10.1016/j.ygyno.2025.08.015. Epub ahead of print. PMID: 40848681.
AI-Augmented authorship: revolutionizing histopathology publishing in the generative AI era.
Gu Q, Li N, Littlefield NG, Gao F, Lamba Saini M, Wang Y, Wheeler BJ, Soong TR, Xia R, Tafti AP. J
Histotechnol. 2025 Jun;48(2):79-81. doi: 10.1080/01478885.2025.2505294. Epub 2025 May 19. PMID: 40384404.
Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation.
Garcia GL, Orellana T, Gorecki G, Frisbie L, Baruwal R, Suresh S, Goldfeld E, Beddows I, MacFawn IP, Britt AK, Hale MM, Elhaw AT, Isett BR, Hempel N, Bao R, Shen H, Buckanovich RJ, Finkel T, Drapkin R, Soong TR, Bruno TC, Atiya HI, Coffman LG.
Cancer Discov. 2025 Jun 3;15(6):1203-1224. doi: 10.1158/2159-8290.CD-24-0805. PMID: 40084985; PMCID: PMC12130807.
Clinicopathologic and molecular characterization of low-grade, early-stage, and HER2-positive invasive breast carcinoma.
Hunter N, Han L, Corbin H, Konnick EQ, Gwin WR 3rd, Vinayak S, Linden H, Audeh W, Samraj L, Menicucci AR; FLEX Investigators Group; Soong TR.
Am J Clin Pathol. 2025 Jun 3;163(6):854-865. doi: 10.1093/ajcp/aqaf010. PMID: 40043195.
Associations between Parity, History of Breastfeeding, and T-cell Profile of Ovarian Tumors.
Mongiovi JM, Townsend MK, Vitonis AF, Harris HR, Doherty JA, Babic A, Hecht JL, Soong TR, Titus L, Conejo-Garcia JR, Fridley BL, Tworoger SS, Terry KL, Sasamoto N.
Cancer Epidemiol Biomarkers Prev. 2025 Apr 3;34(4):550-559. doi: 10.1158/1055-9965.EPI-24-1414. PMID: 39912719; PMCID: PMC11968234.
Adjuvant Therapy in Early Uterine Serous Carcinoma.
Garrett AA, Orellana TH, Soong TR, Rives TA, Taylor SE, Coffman L,Buckanovich R, Mahdi H, Beriwal S, Sukumvanich P, Bhargava R, Olawaiye AB.
Am J Epidemiol. 2025 Jan 16:kwaf008. doi: 10.1093/aje/kwaf008. Epub ahead of print. PMID: 39825498.
Nongenerative Artificial Intelligence in Medicine: Advancements and Applications in Supervised and Unsupervised Machine Learning.
Pantanowitz L, Pearce T, Abukhiran I, Hanna M, Wheeler S, Soong TR, Tafti AP, Pantanowitz J, Lu MY, Mahmood F, Gu Q, Rashidi HH.
Mod Pathol. 2025 Mar;38(3):100680. doi: 10.1016/j.modpat.2024.100680. Epub 2024 Dec 13. PMID: 39675426.
Assessing the impact of deep-learning assistance on the histopathological diagnosis of serous tubal intraepithelial carcinoma (STIC) in fallopian tubes.
Bogaerts JM, Steenbeek MP, Bokhorst JM, van Bommel MH, Abete L, Addante F, Brinkhuis M, Chrzan A, Cordier F, Devouassoux-Shisheboran M, Fernández-Pérez J, Fischer A, Gilks CB, Guerriero A, Jaconi M, Kleijn TG, Kooreman L, Martin S, Milla J, Narducci N, Ntala C, Parkash V, de Pauw C, Rabban JT, Rijstenberg L, Rottscholl R, Staebler A, Van de Vijver K, Zannoni GF, van Zanten M; AI‐STIC Study Group; de Hullu JA, Simons M, van der Laak JA.
J Pathol Clin Res. 2024 Nov;10(6):e70006. doi: 10.1002/2056-4538.70006. PMID: 39439213; PMCID: PMC11496567.
The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions.
MacFawn IP, Magnon G, Gorecki G, Kunning S, Rashid R, Kaiza ME, Atiya H, Ruffin AT, Taylor S, Soong TR, Bao R, Coffman LG, Bruno TC.
Cancer Cell. 2024 Nov 11;42(11):1864-1881.e5. doi: 10.1016/j.ccell.2024.09.007. Epub 2024 Oct 10. PMID: 39393357; PMCID: PMC12236807.
A comprehensive analysis of SOX17 expression by immunohistochemistry in human epithelial tumors, with an emphasis on gynecologic tumors.
Clark BZ, Soong TR, Goel K, Elishaev E, Zhao C, Jones TE, Jones MW, Skvarca LB, Motanagh SA, Carter GJ, Fine JL, Harinath L, Villatoro TM, Yu J, Bhargava R.
Am J Clin Pathol. 2025 Jan 28;163(1):143-152. doi: 10.1093/ajcp/aqae104. PMID: 39240859.
Increased TP53 somatic evolution in peritoneal washes of individuals with BRCA1 germline mutations.
Tee XR, Hazard E, Latorre-Esteves E, Kohrn BF, Ghezelayagh TS, Fredrickson JU, Coombes C, Radke MR, Manhardt E, Katz R, Soong TR, Swisher EM, Norquist BM, Risques RA.
Gynecol Oncol. 2024 Nov;190:18-27. doi: 10.1016/j.ygyno.2024.07.690. Epub 2024 Aug 10. PMID: 39128337; PMCID: PMC11560739.
Diagnosis and management of isolated serous tubal intraepithelial carcinoma: A qualitative focus group study.
Negri S, Fisch C, de Hullu JA, van Bommel M, Simons M, Bogaerts J; Consortium STIC focusgroup; Hermens RPMG, Steenbeek MP.
BJOG. 2024 Dec;131(13):1851-1861. doi: 10.1111/1471-0528.17919. Epub 2024 Jul 25. PMID: 39054407.
Image analysis Uncovers associations between immune landscape, collagen structure, and neoadjuvant chemotherapy in high-grade serous ovarian carcinomas.
Aggarwal A, Corredor G, Fu P, Pathak T, Mirtti T, Modesitt S, Soong TR, Madabhushi A.
Heliyon. 2024 Jun 25;10(13):e33618. doi: 10.1016/j.heliyon.2024.e33618. PMID: 39035539; PMCID: PMC11259872.
Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation.
Garcia GL, Orellana T, Gorecki G, Frisbie LG, Baruwal R, Goldfield E, Beddows I, MacFawn IP, Britt AK, Hale MM, Shen H, Buckanovich R, Finkel T, Drapkin R, Soong TR, Bruno TC, Atiya HI, Coffman L.
bioRxiv [Preprint]. 2024 May 28:2024.05.23.595550. doi: 10.1101/2024.05.23.595550. PMID: 38853994; PMCID: PMC11160569.
Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma.
Saner FAM, Takahashi K, Budden T, Pandey A, Ariyaratne D, Zwimpfer TA, Meagher NS, Fereday S, Twomey L, Pishas KI, Hoang T, Bolithon A, Traficante N; Australian Ovarian Cancer Study Group; Alsop K, Christie EL, Kang EY, Nelson GS, Ghatage P, Lee CH, Riggan MJ, Alsop J, Beckmann MW, Boros J, Brand AH, Brooks- Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, El-Bahrawy MA, Elishaev E, Erber R, Gayther SA, Gentry-Maharaj A, Gilks CB, Harnett PR, Harris HR, Hartmann A, Hein A, Hendley J, Hernandez BY, Jakubowska A, Jimenez-Linan M, Jones ME, Kaufmann SH, Kennedy CJ, Kluz T, Koziak JM, Kristjansdottir B, Le ND, Lener M, Lester J, Lubiński J, Mateoiu C, Orsulic S, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Soong TR, Steed H, Sukumvanich P, Talhouk A, Taylor SE, Vierkant RA, Wang C, Widschwendter M, Wilkens LR, Winham SJ, Anglesio MS, Berchuck A, Brenton JD, Campbell I, Cook LS, Doherty JA, Fasching PA, Fortner RT, Goodman MT, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Menon U, Modugno F, Pharoah PDP, Schildkraut JM, Sundfeldt K, Swerdlow AJ, Goode EL, DeFazio A, Köbel M, Ramus SJ, Bowtell DDL, Garsed DW.
Clin Cancer Res. 2024 Aug 15;30(16):3481-3498. doi: 10.1158/1078-0432.CCR-23-3552. PMID: 38837893; PMCID: PMC11325151.
Genomic Catastrophe (Chromothripsis and Polyploidy) Correlates With Tumor Distribution in Extrauterine High-grade Serous Carcinoma.
Yoon JY, Sharma A, Ligon AH, Ramesh RG, Soong TR, Xian W, Chapel DB, Crum CP.
Am J Surg Pathol. 2024 Aug 1;48(8):1017-1023. doi: 10.1097/PAS.0000000000002229. Epub 2024 Apr 18. PMID: 38639044; PMCID: PMC11254554.
The Malignant Potential of Ovarian Steroid Cell Tumors Revisited: A Multi-institutional Clinicopathologic Analysis of 115 Cases.
Fadare O, Fard EV, Bhargava R, Desouki MM, Hanley KZ, Ip PPC, Li JJX, Lu B, Medeiros F, Ng JHY, Parkash V, Pinto A, Quick CM, Skala SL, Tokuyama M, Turashvili G, Wei CH, Xing D, Zheng W, Soong TR, Howitt BE. Am J Surg Pathol. 2024 May 1;48(5):570-580. doi: 10.1097/PAS.0000000000002201. Epub 2024 Mar 21. PMID: 38512100.
Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions.
Chien YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM.
Am J Surg Pathol. 2024 Apr 1;48(4):475-486. doi: 10.1097/PAS.0000000000002187. Epub 2024 Feb 1. PMID: 38298022; PMCID: PMC10930374.
Implementation of Digital Image Analysis in Assessment of Ki67 Index in Breast Cancer.
Vanderschelden RK, Jerome JA, Gonzalez D, Seigh L, Carter GJ, Clark BZ, Elishaev E, Louis Fine J, Harinath L, Jones MW, Villatoro TM, Soong TR, Yu J, Zhao C, Hartman D, Bhargava R.
Appl Immunohistochem Mol Morphol. 2024 Jan 1;32(1):17-23. doi: 10.1097/PAI.0000000000001171. Epub 2023 Nov 6. PMID: 37937544.
A Novel Humanized Immune Stroma PDX Cancer Model for Therapeutic Studies.
Yang D, Beddows I, Tang H, Cascio S, McGonigal SC, Bai S, Johnson BK, Powers JJ, Acharya R, Bao R, Bruno TC, Soong TR, Conejo-Garcia JR, Shen H, Bility MT, Buckanovich RJ.
bioRxiv [Preprint]. 2023 Jul 3:2023.07.03.547206. doi: 10.1101/2023.07.03.547206. PMID: 37461447; PMCID: PMC10349972.
Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?
Yu J, da Silva EM, La HS, Clark BZ, Fine JL, Carter GJ, Villatoro TM, Soong TR, Lee AV, Oesterreich S, Basili T, Blanco-Heredia J, Selenica P, Ye Q, Da Cruz Paula A, Dopeso H, Gazzo A, Marra A, Pareja F, Reis-Filho JS, Bhargava R.
NPJ Breast Cancer. 2023 Jul 13;9(1):60. doi: 10.1038/s41523-023-00566-7. PMID: 37443169; PMCID: PMC10345141.
Utility of TRPS1 immunohistochemistry in confirming breast carcinoma: Emphasis on staining in triple-negative breast cancers and gynecologic tumors.
Rammal R, Goel K, Elishaev E, Soong TR, Jones MW, Zhao C, Clark BZ, Carter GJ, Yu J, Fine JL, Villatoro TM, Skvarca L, Harinath L, Bhargava R.
Am J Clin Pathol. 2023 Oct 3;160(4):425-434. doi: 10.1093/ajcp/aqad066. PMID: 37352847.
H2Bub1 loss is an early contributor to clear cell ovarian cancer progression.
Ferrari AJ, Rawat P, Rendulich HS, Annapragada AV, Kinose Y, Zhang X, Devins K, Budina A, Scharpf RB, Mitchell MA, Tanyi JL, Morgan MA, Schwartz LE, Soong TR, Velculescu VE, Drapkin R.
JCI Insight. 2023 Jun 22;8(12):e164995. doi: 10.1172/jci.insight.164995. PMID: 37345659; PMCID: PMC10371241.
Comprehensive Review of Serous Tumors of Tubo-Ovarian Origin: Clinical Behavior, Pathological Correlation, Current Molecular Updates, and Imaging Manifestations.
Folsom SM, Berger J, Soong TR, Rangaswamy B.
Curr Probl Diagn Radiol. 2023 Sep-Oct;52(5):425-438. doi: 10.1067/j.cpradiol.2023.05.010. Epub 2023 May 14. PMID: 37286440.
Consensus based recommendations for the diagnosis of serous tubal intraepithelial carcinoma: an international Delphi study.
Bogaerts JMA, van Bommel MHD, Hermens RPMG, Steenbeek MP, de Hullu JA, van der Laak JAWM; STIC consortium; Simons M. Histopathology. 2023 Jul;83(1):67-79. doi: 10.1111/his.14902. Epub 2023 Mar 20. PMID: 36939551.
Multi-institutional Assessment of Pathologist Scoring HER2 Immunohistochemistry.
Robbins CJ, Fernandez AI, Han G, Wong S, Harigopal M, Podoll M, Singh K, Ly A, Kuba MG, Wen H, Sanders MA, Brock J, Wei S, Fadare O, Hanley K, Jorns J, Snir OL, Yoon E, Rabe K, Soong TR, Reisenbichler ES, Rimm DL.
Mod Pathol. 2023 Jan;36(1):100032. doi: 10.1016/j.modpat.2022.100032. PMID: 36788069; PMCID: PMC10278086.
The role of adjuvant treatment for early-stage uterine clear cell carcinomas.
Orellana TJ, Garrett AA, Soong TR, Rives T, Courtney-Brooks M, Taylor SE, Lesnock J, Berger J, Boisen M, Coffman L, Buckanovich R, Mahdi H, Comerci JC, Beriwal S, Sukumvanich P, Edwards RP, Bhargava R, Olawaiye AB.
Gynecol Oncol. 2023 Mar;170:77-83. doi: 10.1016/j.ygyno.2022.12.024. Epub 2023 Jan 13. PMID: 36641903; PMCID: PMC11229708.
Enhancing mRNA therapy through iterative delivery.
Seaberg J, Gulla SK, Labombarde J, Roy R, Dwivedi SKD, Xu C, Kovats S, Bhattacharya R, Mukherjee P.
Sci Adv. 2025 Oct 3;11(40):eadx0916. doi: 10.1126/sciadv.adx0916. Epub 2025 Oct 1. PMID: 41032607; PMCID: PMC12487881.
Anoikis resistance in Cancer: Mechanisms, therapeutic strategies, potential targets, and models for enhanced understanding.
Shaw P, Dey Bhowmik A, Gopinatha Pillai MS, Robbins N, Dwivedi SKD, Rao G.
Cancer Lett. 2025 Aug 1;624:217750. doi: 10.1016/j.canlet.2025.217750. Epub 2025 Apr 26. PMID: 40294841.
Evolving landscape of detection and targeting miRNA/epigenetics for therapeutic strategies in ovarian cancer.
Dey Bhowmik A, Shaw P, Gopinatha Pillai MS, Rao G, Dwivedi SKD.
Cancer Lett. 2024 Nov 29;611:217357. doi: 10.1016/j.canlet.2024.217357. Epub ahead of print. PMID: 39615646; PMCID: PMC12119979.
Secrets of DNA-PKcs beyond DNA repair.
Camfield S, Chakraborty S, Dwivedi SKD, Pramanik PK, Mukherjee P, Bhattacharya R. NPJ Precis Oncol. 2024 Jul 23;8(1):154. doi: 10.1038/s41698-024-00655-1. PMID: 39043779; PMCID: PMC11266574.
VEGF signaling: Role in angiogenesis and beyond.
Shaw P, Dwivedi SKD, Bhattacharya R, Mukherjee P, Rao G.
Biochim Biophys Acta Rev Cancer. 2024 Mar;1879(2):189079. doi: 10.1016/j.bbcan.2024.189079. Epub 2024 Jan 26. PMID: 38280470.
A role for the cystathionine-β-synthase /H2S axis in astrocyte dysfunction in the aging brain.
Dey A, Pramanik PK, Dwivedi SKD, Neizer-Ashun F, Kiss T, Ganguly A, Rice H, Mukherjee P, Xu C, Ahmad M, Csiszar A, Bhattacharya R.
Redox Biol. 2023 Dec;68:102958. doi: 10.1016/j.redox.2023.102958. Epub 2023 Nov 6. PMID: 37948927; PMCID: PMC10663824. 7. uTERINE
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Yearly Publications
Oct 14, 2023
Characterizing the regulatory Fas (CD95) epitope critical for agonist antibody targeting and CAR-T bystander function in ovarian cancer.
Mondal T, Gaur H, Wamba BEN, Michalak AG, Stout C, Watson MR, Aleixo SL, Singh A, Condello S, Faller R, Leiserowitz GS, Bhatnagar S, Tushir-Singh J. Cell Death Differ. 2023 Oct 14. doi: 10.1038/s41418-023-01229-7. Epub ahead of print. PMID: 37838774.
Aug 1, 2023
Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci.
Kanholm T, Rentia U, Hadley M, Karlow JA, Cox OL, Diab N, Bendall ML, Dawson T, McDonald JI, Xie W, Crandall KA, Burns KH, Baylin SB, Easwaran H, Chiappinelli KB. Cancer Res. 2023 Aug 1;83(15):2584-2599. doi: 10.1158/0008-5472.CAN-22-3485.
Aug 1, 2023
Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML.
Letson CT, Balasis ME, Newman H, Binder M, Vedder A, Kinose F, Ball M, Kruer T, Quintana A, Lasho TL, Finke CM, Almada LL, Grants JM, Zhang G, Fernandez-Zapico ME, Gaspar-Maia A, Lancet J, Komrokji R, Haura E, Sallman DA, Reuther GW, Karsan A, Rix U, Patnaik MM, Padron E.Clin Cancer Res. 2023 Aug 1;29(15):2919-2932. doi: 10.1158/1078-0432.CCR-22-3929.
Aug 1, 2023
Plasma proteomic profiles of pain subtypes in adolescents and young adults with endometriosis.
Sasamoto N, Ngo L, Vitonis AF, Dillon ST, Sieberg CB, Missmer SA, Libermann TA, Terry KL.Hum Reprod. 2023 Aug 1;38(8):1509-1519. doi: 10.1093/humrep/dead099.
Jul 25, 2023
Engineered tumor-specific T cells using immunostimulatory photothermal nanoparticles.
Sweeney EE, Sekhri P, Telaraja D, Chen J, Chin SJ, Chiappinelli KB, Sanchez CE, Bollard CM, Cruz CRY, Fernandes R.Cytotherapy. 2023 Jul;25(7):718-727. doi: 10.1016/j.jcyt.2023.03.014.
Jul 13, 2023
Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?
Yu J, da Silva EM, La HS, Clark BZ, Fine JL, Carter GJ, Villatoro TM, Soong TR, Lee AV, Oesterreich S, Basili T, Blanco-Heredia J, Selenica P, Ye Q, Da Cruz Paula A, Dopeso H, Gazzo A, Marra A, Pareja F, Reis-Filho JS, Bhargava R.NPJ Breast Cancer. 2023 Jul 13;9(1):60. doi: 10.1038/s41523-023-00566-7.
Jul 12, 2023
Racial and ethnic differences in tumor characteristics among endometrial cancer patients in an equal-access healthcare population.
Desmond D, Arter Z, Berenberg JL, Killeen JL, Bunch K, Merritt MA. Cancer Causes Control. 2023 Jul 12. doi: 10.1007/s10552-023-01716-9.
Jun 23, 2023
Utility of TRPS1 immunohistochemistry in confirming breast carcinoma: Emphasis on staining in triple-negative breast cancers and gynecologic tumors.
Rammal R, Goel K, Elishaev E, Soong TR, Jones MW, Zhao C, Clark BZ, Carter GJ, Yu J, Fine JL, Villatoro TM, Skvarca L, Harinath L, Bhargava R.Am J Clin Pathol. 2023 Jun 23:aqad066. doi: 10.1093/ajcp/aqad066.
Jun 22, 2023
H2Bub1 loss is an early contributor to clear cell ovarian cancer progression.
Ferrari AJ, Rawat P, Rendulich HS, Annapragada AV, Kinose Y, Zhang X, Devins K, Budina A, Scharpf RB, Mitchell MA, Tanyi JL, Morgan MA, Schwartz LE, Soong TR, Velculescu VE, Drapkin R.JCI Insight. 2023 Jun 22;8(12):e164995. doi: 10.1172/jci.insight.164995.
Jun 14, 2023
Patterns of cervical cancer screening follow-up in the era of prolonged screening intervals.
Kulkarni A, Chen L, Gockley A, Khoury-Collado F, Hou J, Clair CST, Melamed A, Hershman DL, Wright JD.Gynecol Oncol. 2023 Aug;175:53-59. doi: 10.1016/j.ygyno.2023.06.007.
Jun 14, 2023
Trends in the use of neoadjuvant chemotherapy for low-grade serous ovarian cancer in the United States.
Kulkarni A, Chen L, Gockley A, Khoury-Collado F, Hou J, Clair CST, Melamed A, Hershman DL, Wright JD.Gynecol Oncol. 2023 Aug;175:53-59. doi: 10.1016/j.ygyno.2023.06.007.
Jun 13, 2023
Cancer-directed surgery in patients with metastatic cancer: A systematic review and meta-analysis of randomized evidence.
Abel MK, Myers EL, Minkin E, Tahir P, Haynes AB, Wright JD, Rauh-Hain JA, Melamed A. Cancer Med. 2023 Jul;12(13):14072-14083. doi: 10.1002/cam4.6061. Epub 2023 Jun 13.
Jun 10, 2023
Characterization and Optimization of Multiomic Single-Cell Epigenomic Profiling.
Sandoval L, Mohammed Ismail W, Mazzone A, Dumbrava M, Fernandez J, Munankarmy A, Lasho T, Binder M, Simon V, Kim KH, Chia N, Lee JH, Weroha SJ, Patnaik M, Gaspar-Maia A. Genes (Basel). 2023 Jun 10;14(6):1245. doi: 10.3390/genes14061245.
Jun 1, 2023
Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies.
Hathaway CA, Conejo-Garcia JR, Fridley BL, Rosner B, Saeed-Vafa D, Moran Segura C, Nguyen JV, Hecht JL, Sasamoto N, Terry KL, Tworoger SS, Townsend MK.Cancer Epidemiol Biomarkers Prev. 2023 Jun 1;32(6):848-853. doi: 10.1158/1055-9965.EPI-22-1285.
May 26, 2023
DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.
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Naumann JA, Argyris PP, Carpenter MA, Gupta HB, Chen Y, Temiz NA, Zhou Y, Durfee C, Proehl J, Koniar BL, Conticello SG, Largaespada DA, Brown WL, Aihara H, Vogel RI, Harris RS.Int J Mol Sci. 2023 May 26;24(11):9305. doi: 10.3390/ijms24119305.
May 15, 2023
Succinate based polymers drive immunometabolism in dendritic cells to generate cancer immunotherapy.
Inamdar S, Suresh AP, Mangal JL, Ng ND, Sundem A, Behbahani HS, Rubino TE Jr, Shi X, Loa ST, Yaron JR, Hitosugi T, Green M, Gu H, Curtis M, Acharya AP. J Control Release. 2023 Jun;358:541-554. doi: 10.1016/j.jconrel.2023.05.014.
May 14, 2023
Comprehensive Review of Serous Tumors of Tubo-Ovarian Origin: Clinical Behavior, Pathological Correlation, Current Molecular Updates, and Imaging Manifestations.
Folsom SM, Berger J, Soong TR, Rangaswamy B.Curr Probl Diagn Radiol. 2023 May 14:S0363-0188(23)00074-9. doi: 10.1067/j.cpradiol.2023.05.010.
May 4, 2023
Combination Therapy, Including Bevacizumab, for Advanced Colorectal Cancer.
Yeku OO, Longo DL.N Engl J Med. 2023 May 4;388(18):1711-1714. doi: 10.1056/NEJMe2300385.
Apr 14, 2023
Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors.
Kim DJ, Anandh S, Null JL, Przanowski P, Bhatnagar S, Kumar P, Shelton SE, Grundy EE, Chiappinelli KB, Kamm RD, Barbie DA, Dudley AC.Nat Commun. 2023 Apr 14;14(1):2122. doi: 10.1038/s41467-023-37807-z.
Apr 6, 2023
CAR T Cells for Neuroblastoma.
Yeku OO, Longo DL.N Engl J Med. 2023 Apr 6;388(14):1328-1331. doi: 10.1056/NEJMe2300317.
Apr 5, 2023
Systemic Progestins and Progestin-Releasing Intrauterine Device Therapy for Premenopausal Patients With Endometrial Intraepithelial Neoplasia.
Suzuki Y, Chen L, Hou JY, St Clair CM, Khoury-Collado F, de Meritens AB, Matsuo K, Melamed A, Hershman DL, Wright JD.Obstet Gynecol. 2023 May 1;141(5):979-987. doi: 10.1097/AOG.0000000000005124.
Apr 3, 2023
Endothelial Dysfunction in Breast Cancer Survivors on Aromatase Inhibitors: Changes over Time.
Shaaban A, Petersen A, Beckwith H, Florea N, Potter DA, Yee D, Vogel RI, Duprez D, Blaes AH.Res Sq. 2023 Apr 3:rs.3.rs-2758909. doi: 10.21203/rs.3.rs-2758909/v1.
Mar 26, 2023
Minimally invasive interval debulking surgery for advanced ovarian cancer after neoadjuvant chemotherapy.
Jorgensen K, Melamed A, Wu CF, Nitecki R, Pareja R, Fagotti A, Schorge JO, Ramirez PT, Rauh-Hain JA.Gynecol Oncol. 2023 May;172:130-137. doi: 10.1016/j.ygyno.2023.01.017.
Mar 25, 2023
Single cell proteogenomic analysis of aberrant monocytosis in TET2 mutant premalignant and malignant hematopoiesis.
Lasho T, Finke C, Timm M, Tefferi A, Mangaonkar A, Olteanu H, Reichard K, Ketterling R, Gangat N, Xie Z, Fernandez J, Chia N, Gaspar-Maia A, Binder M, Patnaik MM.Leukemia. 2023 Jun;37(6):1384-1387. doi: 10.1038/s41375-023-01887-z.
Mar 3, 2023
Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+ patients with HPV16+ solid tumors.
Jimeno A, Baranda J, Iams WT, Park JC, Mita M, Gordon MS, Taylor M, Dhani N, Leal AD, Neupane P, Eng C, Yeku O, Mita A, Moser JC, Butler M, Loughhead SM, Jennings J, Miselis NR, Ji RR, Nair N, Kornacker M, Zwirtes RF, Bernstein H, Sharei A.Invest New Drugs. 2023 Apr;41(2):284-295. doi: 10.1007/s10637-023-01342-x.
Feb 25, 2023
Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases.
Durfee C, Temiz NA, Levin-Klein R, Argyris PP, Als E L, Carracedo S, de la Vega AA, Proehl J, Holzhauer AM, Seeman ZJ, Lin YT, Vogel RI, Sotillo R, Nilsen H, Harris RS.bioRxiv. 2023 Feb 25:2023.02.24.529970. doi: 10.1101/2023.02.24.529970.
Feb 23, 2023
MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming.
Mohammed Ismail W, Mazzone A, Ghiraldini FG, Kaur J, Bains M, Munankarmy A, Bagwell MS, Safgren SL, Moore-Weiss J, Buciuc M, Shimp L, Leach KA, Duarte LF, Nagi CS, Carcamo S, Chung CY, Hasson D, Dadgar N, Zhong J, Lee JH, Couch FJ, Revzin A, Ordog T, Bernstein E, Gaspar-Maia A. Commun Biol. 2023 Feb 23;6(1):215. doi: 10.1038/s42003-023-04571-1.
Feb 14, 2023
Medical and surgical retreatment for uterine leiomyoma after myomectomy.
Li AH, Chen L, Melamed A, Hershman DL, Wright JD.BJOG. 2023 Jun;130(7):835-837. doi: 10.1111/1471-0528.17409.
Feb 10, 2023
A UVR-sensor wearable device intervention to reduce sun exposure in melanoma survivors: Results from a randomized controlled trial.
Vogel RI, Luo X, Brown K, Jewett P, Dona AC, Nagler RH, Ahmed RL, Martinson BC, Lazovich D.PLoS One. 2023 Feb 10;18(2):e0281480. doi: 10.1371/journal.pone.0281480.
Feb 2, 2023
Functional and psychosocial quality of life in gynecologic Cancer survivors with and without lymphedema symptoms.
Koehler L, Penz LE, John F, Stenzel A, Jewett P, Teoh D, Blaes A, Rivard C, Vogel R. Gynecol Oncol. 2023 Mar;170:254-258. doi: 10.1016/j.ygyno.2023.01.019.
Feb 1, 2023
Trends in Episode-of-Care Spending for Cancer-Directed Surgery Among US Medicare Beneficiaries From 2011 to 2019.
Melamed A, Lin YL, Hassan AM, Rauh-Hain JA, Herring B, Keating NL, Offodile AC 2nd.JAMA Surg. 2023 Feb 1;158(2):216-218. doi: 10.1001/jamasurg.2022.4493.
Jan 27, 2023
Epigenetically programmed resistance to chemo- and immuno-therapies.
Walker RR, Rentia Z, Chiappinelli KB. Adv Cancer Res. Jan 27 2023;158:41-71. doi:10.1016/bs.acr.2022.12.001
Jan 24, 2023
Predictors of residual disease after debulking surgery in advanced stage ovarian cancer.
Abbas-Aghababazadeh F, Sasamoto N, Townsend MK, Huang T, Terry KL, Vitonis AF, Elias KM, Poole EM, Hecht JL, Tworoger SS, Fridley BL.Front Oncol. 2023 Jan 24;13:1090092. doi: 10.3389/fonc.2023.1090092.
Jan 19, 2023
Genetic variants associated with post-traumatic stress symptoms in patients with gynecologic cancer.
Johnson AM, Teoh D, Jewett P, Darst BF, Mattson J, Hoffmann C, Brown K, Makaram A, Keller C, Blaes AH, Everson-Rose SA, Vogel RI. Gynecol Oncol. 2023 Mar;170:102-107. doi: 10.1016/j.ygyno.2023.01.006.
Jan 16, 2023
Multi-institutional Assessment of Pathologist Scoring HER2 Immunohistochemistry.
Robbins CJ, Fernandez AI, Han G, Wong S, Harigopal M, Podoll M, Singh K, Ly A, Kuba MG, Wen H, Sanders MA, Brock J, Wei S, Fadare O, Hanley K, Jorns J, Snir OL, Yoon E, Rabe K, Soong TR, Reisenbichler ES, Rimm DL.Mod Pathol. 2023 Jan;36(1):100032. doi: 10.1016/j.modpat.2022.100032.
Jan 4, 2023
Use of Conservative Therapies Before Hysterectomy for Uterine Leiomyomas.
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Dec 7, 2022
PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling.
Raja, R., Wu, C. L., Rubino, T. E., Utagawa, E., Magtibay, P. M., Butler, K. A., & Curtis, M. Journ. Immunotherapy of Cancer vol 19, no 12. 2022 Dec 1; e005026 DOI: 10.1136/jitc-2022-005026
Nov 7, 2022
Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer
Gomez, S., Cox, O. L., Walker, R. R., 3rd, Rentia, U., Hadley, M., Arthofer, E., Diab, N., Grundy, E. E., Kanholm, T., McDonald, J. I., Kobyra, J., Palmer, E., Noonepalle, S., Villagra, A., Leitenberg, D., Bollard, C. M., Saunthararajah, Y., & Chiappinelli, K. B. J Immunother cancer vol. 10,11 Nov 7 2022; e004974. doi:10.1136/jitc-2022-004974
Oct 1, 2022
Pre-diagnosis and post-diagnosis dietary patterns and survival in women with ovarian cancer
Sasamoto N, Ngo L, Vitonis AF, Dillon ST, Missmer SA, Libermann TA, Terry KL. Hum Reprod. 2022 AUG 25; 37(9):2042-2053. DOI: 10.1093/humrep/deac146. PMID: 35770801.
Aug 25, 2022
Circulating proteomic profiles associated with endometriosis in adolescents and young adults
Sasamoto N, Ngo L, Vitonis AF, Dillon ST, Missmer SA, Libermann TA, Terry KL. Hum Reprod. 2022 AUG 25; 37(9):2042-2053. DOI: 10.1093/humrep/deac146. PMID: 35770801.
Aug 5, 2022
Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer
Chae CS, Sandoval TA, Hwang SM, Park ES, Giovanelli P, Awasthi D, Salvagno C, Emmanuelli A, Tan C, Chaudhary V, Casado J, Kossenkov AV, Song M, Barrat FJ, Holcomb K, Romero-Sandoval EA, Zamarin D, Pepin D, D'Andrea AD, Färkkilä A, Cubillos-Ruiz JR. Cancer Discov. 2022 AUG 05; 12(8):1904-1921. DOI: 10.1158/2159-8290.CD-21-1181. PMID: 35552618.
Aug 5, 2022
Trends in pelvic pain symptoms over two years of follow-up among adolescents and young adults with and without endometriosis
Sasamoto N, Shafrir AL, Wallace BM, Vitonis AF, Fraer CJ, Gallagher JS, DePari M, Ghiasi M, Laufer MR, Sieberg CB, DiVasta AD, Schrepf A, As-Sanie S, Terry KL, Missmer SA. Pain. 2022 AUG 09; DOI: 10.1097/j.pain.0000000000002747. PMID: 35947080.
Aug 1, 2022
Treatment of ovarian clear cell carcinoma with immune checkpoint blockade: a case series
Sia TY, Manning-Geist B, Gordhandas S, Murali R, Marra A, Liu YL, Friedman CF, Hollmann TJ, Zivanovic O, Chi DS, Weigelt B, Konner JA, Zamarin D. Int J Gynecol Cancer. 2022 AUG 01; 32(8):1017-1024. DOI: 10.1136/ijgc-2022-003430. PMID: 35545291.
Jul 20, 2022
Tissue transglutaminase activates integrin-linked kinase and
Condello, Salvatore et al. J Biol Chem vol. 298,8 Aug. 2022; 102242. doi:10.1016/j.jbc.2022.102242
Jul 20, 2022
Extra cycles of neoadjuvant chemotherapy before interval surgery for ovarian cancer: the more the merrier or too much of a good thing?
Nitecki, Roni, and Alexander Melamed. Int. J Gnecol cancer Jul. 2022; doi:10.1136/ijgc-2022-003796.
Jul 15, 2022
Inhibiting DNA methylation improves antitumor immunity in ovarian cancer
Chiappinelli KB, Baylin SB. J. Clin. Invest. 2022 JUL 15; 132(14). DOI: 10.1172/JCI160186. PMID: 35838045.
Jun 1, 2022
Presurgical blood metabolites and risk of postsurgical pelvic pain in young patients with endometriosis
Sasamoto N, Zeleznik OA, Vitonis AF, Missmer SA, Laufer MR, Avila-Pacheco J, Clish CB, Terry KL. Fertil Steril. 2022 JUN 01; 117(6):1235-1245. DOI: 10.1016/j.fertnstert.2022.02.012. PMID: 35367064.
May 29, 2022
The Outside-In Journey of Tissue Transglutaminase in Cancer
Sima, L. E., Matei, D., & Condello, S. Cells vol. 11,11 1779. May 29 2022; doi:10.3390/cells11111779
May 13, 2022
Lifetime ovulatory years and ovarian cancer gene expression profiles
Sasamoto N, Stewart PA, Wang T, Yoder SJ, Chellappan S, Hecht JL, Fridley BL, Terry KL, Tworoger SS. J Ovarian Res. 2022 MAY 13; 15(1):59. DOI: 10.1186/s13048-022-00995-1. PMID: 35562768.
May 4, 2022
Dual Fluorescence Isogenic Synthetic Lethal Kinase Screen and High-Content Secondary Screening for MUC16/CA125-Selective Agents
Rao TD, Xu M, Eng S, Yang G, Manson R, Rosales N, Kumar R, Veillard IE, Zhou Q, Iasonos A, Ouerfelli O, Djaballah H, Spriggs DR, Yeku OO. Mol. Cancer Ther. 2022 MAY 04; 21(5):775-785. DOI: 10.1158/1535-7163.MCT-21-0572. PMID: 35413118.
Apr 12, 2022
A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives
Arend RC, Scalise CB, Gordon ER, Davis AM, Foxall ME, Johnston BE, Crossman DK, Cooper SJ. Clin. Cancer Res. 2022 APR 01; 28(7):1433-1445. DOI: 10.1158/1078-0432.CCR-21-2984. PMID: 35031546.
Apr 1, 2022
Metabolic Alterations and WNT Signaling Impact Immune Response in HGSOC
Arend RC, Scalise CB, Gordon ER, Davis AM, Foxall ME, Johnston BE, Crossman DK, Cooper SJ. Clin. Cancer Res. 2022 APR 01; 28(7):1433-1445. DOI: 10.1158/1078-0432.CCR-21-2984. PMID: 35031546.
Mar 1, 2022
Transposable element regulation and expression in cancer
Grundy EE, Diab N, Chiappinelli KB. FEBS J. 2022 MAR 01; 289(5):1160-1179. DOI: 10.1111/febs.15722. PMID: 33471418.
Mar 1, 2022
Beyond T Cells: IgA Incites Immune Recognition in Endometrial Cancer
Osorio JC, Zamarin D. Cancer Res. 2022 MAR 01; 82(5):766-768. DOI: 10.1158/0008-5472.CAN-21-4385. PMID: 35247898.
Feb 4, 2022
Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2
Samuel D, Diaz-Barbe A, Pinto A, Schlumbrecht M, George S. Cells. 2022 FEB 04; 11(3). DOI: 10.3390/cells11030539. PMID: 35159349.
Feb 1, 2022
High-intermediate risk endometrial cancer: moving toward a molecularly based risk assessment profile
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Kako TD, Kamal MZ, Dholakia J, Scalise CB, Arend RC. Int J Clin Oncol. 2022 FEB 01; 27(2):323-331. DOI: 10.1007/s10147-021-02089-2. PMID: 35038071.
Feb 1, 2022
Response to anti-DKK1 therapy in uterine carcinosarcoma: A case report
ElNaggar A, Zhang N, Scalise CB, Sirard C, Kagey MH, Vaena D, Arend R. Gynecol Oncol Rep. 2022 FEB 01; 39:100904. DOI: 10.1016/j.gore.2021.100904. PMID: 35531363.
Jan 15, 2022
Racial/ethnic differences in postmenopausal breast cancer risk by hormone receptor status: The multiethnic cohort study
Sarink D, White KK, Loo LWM, Wu AH, Wilkens LR, Le Marchand L, Park SY, Setiawan VW, Merritt MA. Int J Cancer. 2022 JAN 15; 150(2):221-231. DOI: 10.1002/ijc.33795. PMID: 34486728.
Jan 1, 2022
Sequential modulation of the Wnt/β-catenin signaling pathway enhances tumor-intrinsic MHC I expression and tumor clearance
Uhlitz F, Zamarin D. Cancer Cell. 2021 DEC 13; 39(12):1567-1569. DOI: 10.1016/j.ccell.2021.10.011. PMID: 34739843.
Jan 1, 2022
Effect of Mismatch Repair Status on Outcome of Early-Stage Grade 1 to 2 Endometrial Cancer Treated With Vaginal Brachytherapy
Uhlitz F, Zamarin D. Cancer Cell. 2021 DEC 13; 39(12):1567-1569. DOI: 10.1016/j.ccell.2021.10.011. PMID: 34739843.
Dec 13, 2021
Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill
Uhlitz F, Zamarin D. Cancer Cell. 2021 DEC 13; 39(12):1567-1569. DOI: 10.1016/j.ccell.2021.10.011. PMID: 34739843.
Dec 1, 2021
Why Black women with ovarian cancer require greater focus
George S. Nature. 2021 DEC 01; 600(7889):S39. DOI: 10.1038/d41586-021-03715-9. PMID: 34912099.
Oct 15, 2021
Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
McDonald JI, Diab N, Arthofer E, Hadley M, Kanholm T, Rentia U, Gomez S, Yu A, Grundy EE, Cox O, Topper MJ, Xing X, Strissel PL, Strick R, Wang T, Baylin SB, Chiappinelli KB. Cancer Res. 2021 OCT 15; 81(20):5176-5189. DOI: 10.1158/0008-5472.CAN-20-4243. PMID: 34433584.
Oct 1, 2021
Systematic Next Generation Sequencing is feasible in clinical practice and identifies opportunities for targeted therapy in women with uterine cancer: Results from a prospective cohort study
Arend RC, Goel N, Roane BM, Foxall ME, Dholakia J, Londoño AI, Wall JA, Leath CA, Huh WK. Gynecol Oncol. 2021 OCT 01; 163(1):85-92. DOI: 10.1016/j.ygyno.2021.07.017. PMID: 34372972.
Sep 1, 2021
Strategies in Overcoming Homologous Recombination Proficiency and PARP Inhibitor Resistance
Goel N, Foxall ME, Scalise CB, Wall JA, Arend RC. Mol. Cancer Ther. 2021 SEP 01; 20(9):1542-1549. DOI: 10.1158/1535-7163.MCT-20-0992. PMID: 34172532.
Aug 1, 2021
Common Analgesic Use for Menstrual Pain and Ovarian Cancer Risk
Sasamoto N, Babic A, Vitonis AF, Titus L, Cramer DW, Trabert B, Tworoger SS, Terry KL. Cancer Prev Res (Phila). 2021 AUG 01; 14(8):795-802. DOI: 10.1158/1940-6207.CAPR-21-0090. PMID: 34244153.
Jul 2, 2021
Instruction of Immunometabolism by Adipose Tissue: Implications for Cancer Progression
Raja R, Wu C, Limbeck F, Butler K, Acharya AP, Curtis M. Cancers (Basel). 2021 JUL 02; 13(13). DOI: 10.3390/cancers13133327. PMID: 34283042.
May 20, 2021
Case 15-2021: A 76-Year-Old Woman with Nausea, Diarrhea, and Acute Kidney Failure
Yeku OO, Medford AJ, Fenves AZ, Uljon SN. N. Engl. J. Med.. 2021 MAY 20; 384(20):1943-1950. DOI: 10.1056/NEJMcpc2100274. PMID: 34010534.
May 1, 2021
Black Is Diverse: The Untapped Beauty and Benefit of Cancer Genomics and Precision Medicine
George S, Ragin C, Ashing KT. JCO Oncol Pract. 2021 MAY 01; 17(5):279-283. DOI: 10.1200/OP.21.00236. PMID: 33974833.
May 1, 2021
Prospective Analyses of Lifestyle Factors Related to Energy Balance and Ovarian Cancer Risk by Infiltration of Tumor-Associated Macrophages
Sasamoto N, Wang T, Townsend MK, Hecht JL, Eliassen AH, Song M, Terry KL, Tworoger SS, Harris HR. Cancer Epidemiol Biomarkers Prev. 2021 MAY 01; 30(5):920-926. DOI: 10.1158/1055-9965.EPI-20-1686. PMID: 33653814.
May 1, 2021
Utilizing an interim futility analysis of the OVAL study (VB-111-701/GOG 3018) for potential reduction of risk: A phase III, double blind, randomized controlled trial of ofranergene obadenovec (VB-111) and weekly paclitaxel in patients with platinum resistant ovarian cancer
Arend RC, Monk BJ, Herzog TJ, Moore KN, Shapira-Frommer R, Ledermann JA, Tewari KS, Secord AA, Rachmilewitz Minei T, Freedman LS, Miller A, Shmueli SF, Lavi M, Penson RT. Gynecol Oncol. 2021 MAY 01; 161(2):496-501. DOI: 10.1016/j.ygyno.2021.02.014. PMID: 33637348.
Apr 2, 2021
Assessing Preclinical Research Models for Immunotherapy for Gynecologic Malignancies
Dholakia J, Scalise C, Arend RC. Cancers (Basel). 2021 APR 02; 13(7). DOI: 10.3390/cancers13071694. PMID: 33918476.
Mar 1, 2021
Expanding Our Impact in Cervical Cancer Treatment: Novel Immunotherapies, Radiation Innovations, and Consideration of Rare Histologies
Randall LM, Walker AJ, Jia AY, Miller DT, Zamarin D. Am Soc Clin Oncol Educ Book. 2021 MAR 01; 41:252-263. DOI: 10.1200/EDBK_320411. PMID: 34010052.
Mar 1, 2021
Racial/ethnic differences in average CA125 and CA15.3 values and its correlates among postmenopausal women in the USA
Sasamoto N, Vitonis AF, Fichorova RN, Yamamoto HS, Terry KL, Cramer DW. Cancer Causes Control. 2021 MAR 01; 32(3):299-309. DOI: 10.1007/s10552-020-01384-z. PMID: 33462738.
Mar 1, 2021
Neutralization of TGFβ Improves Tumor Immunity and Reduces Tumor Progression in Ovarian Carcinoma
Roane BM, Meza-Perez S, Katre AA, Goldsberry WN, Randall TD, Norian LA, Birrer MJ, Arend RC. Mol. Cancer Ther.. 2021 MAR 01; 20(3):602-611. DOI: 10.1158/1535-7163.MCT-20-0412. 2020 Dec 15. PubMed PMID: 33323456; PMCID: PMC7933076.
Mar 1, 2021
201cGene Sequencing for Pathogenic Variants Among Adults With Breast and Ovarian Cancer in the Caribbean
George SHL, Donenberg T, Alexis C, DeGennaro V, Dyer H, Yin S, Ali J, Butler R, Chin SN, Curling D, Lowe D, Lunn J, Turnquest T, Wharfe G, Cerbon D, Barreto-Coelho P, Schlumbrecht MP, Akbari MR, Narod SA, Hurley JE. JAMA Netw Open. 2021 MAR 01; 4(3):e210307. DOI: 10.1001/jamanetworkopen.2021.0307. PMID: 33646313.
Feb 1, 2021
Ovarian cancer: new strategies and emerging targets for the treatment of patients with advanced disease
Arend RC, Jackson-Fisher A, Jacobs IA, Chou J, Monk BJ. Ovarian cancer: new strategies and emerging targets for the treatment of patients with advanced disease. Cancer Biol Ther. 2021 FEB 01; 22(2):89-105. DOI: 10.1080/15384047.2020.1868937. PMID: 33427569.
Jan 1, 2021
An Assessment of Ovarian Cancer Histotypes Across the African Diaspora
George SHL, Omotoso A, Pinto A, Mustapha A, Sanchez-Covarrubias AP, Umar UA, Umar AB, Oluwasola TA, Okolo CA, Anthony UU, Ukekwe FI, Bakari MA, Dahiru AMC, Abdullahi HI, Abimiku BA, Abdurrahman A, Usman A, Ahmed SA, Usman HA, Kabir A, Eleje GU, Chiemeka ME, Nzeribe E, Nweke I, Kadas S, et al. Front Oncol. 2021 JAN 01; 11:732443. DOI: 10.3389/fonc.2021.732443. PMID: 34900682.
Jan 1, 2021
Utilization of a 3-D tissue engineered model to investigate the effects of perfusion on gynecologic cancer biology
Martinez A, Buckley MS, Scalise CB, Wang D, Katre AA, Birrer MJ, Berry JL, Arend RC. J Tissue Eng. 2021 JAN 01; 12:20417314211055015. DOI: 10.1177/20417314211055015. PMID: 34820113.
Jan 1, 2021
Class I histone deacetylase inhibition promotes CD8 T cell activation in ovarian cancer
McCaw TR, Goel N, Brooke DJ, Katre AA, Londoño AI, Smith HJ, Randall TD, Arend RC. Cancer Med. 2021 JAN 01; 10(2):709-717. DOI: 10.1002/cam4.3337. PMID: 33369199.
Nov 1, 2020
mRNA expression in low grade serous ovarian cancer: Results of a nanoString assay in a diverse population
Jordan SE, Saad H, Covarrubias AS, Siemon J, Pearson JM, Slomovitz BM, Huang M, Pinto A, Schlumbrecht M, George SH. Gynecol Oncol. 2020 NOV 01; 159(2):554-562. DOI: 10.1016/j.ygyno.2020.08.030. PMID: 32951896.
Oct 1, 2020
Peripheral Blood Leukocyte Telomere Length and Endometriosis
Sasamoto N, Yland J, Vitonis AF, Cramer DW, Titus LJ, De Vivo I, Missmer SA, Terry KL. Reprod Sci. 2020 OCT 01; 27(10):1951-1959. DOI: 10.1007/s43032-020-00214-6. PMID: 32578161.
Oct 1, 2020
Combining epigenetic and immune therapy to overcome cancer resistance
Gomez S, Tabernacki T, Kobyra J, Roberts P, Chiappinelli KB. Semin Cancer Biol. 2020 OCT 01; 65:99-113. DOI: 10.1016/j.semcancer.2019.12.019. PMID: 31877341.
Oct 1, 2020
Phase II study of atezolizumab in combination with bevacizumab in patients with advanced cervical cancer
Phase II study of atezolizumab in combination with bevacizumab in patients with advanced cervical cancer
Sep 28, 2020
Aromatase inhibitor use, side effects and discontinuation rates in gynecologic oncology patients
Bell SG, Dalton L, McNeish BL, Fang F, Henry NL, Kidwell KM, McLean K.. Gynecol Oncol. 2020 Aug 23:S0090-8258(20)33816-6. doi: 10.1016/j.ygyno.2020.08.015. Online ahead of print.
Sep 21, 2020
The m(6)A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor
Xiao Y, Thakkar KN, Zhao H, Broughton J, Li Y, Seoane JA, Diep AN, Metzner TJ, von Eyben R, Dill DL, Brooks JD, Curtis C, Leppert JT, Ye J, Peehl DM, Giaccia AJ, Sinha S, Rankin EB.. Proc Natl Acad Sci U S A. 2020 Aug 19:202000516. doi: 10.1073/pnas.2000516117. Online ahead of print.
Jul 31, 2020
Carcinoma-Associated Mesenchymal Stem Cells Promote Chemoresistance in Ovarian Cancer Stem Cells via PDGF Signaling
Raghavan S, Snyder CS, Wang A, McLean K, Zamarin D, Buckanovich RJ, Mehta G.. Cancers (Basel). 2020 Jul 27;12(8):E2063. doi: 10.3390/cancers12082063.
Jun 27, 2020
Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study
Zamarin D, Hamid O, Nayak-Kapoor A, Sahebjam S, Sznol M, Collaku A, Fox FE, Marshall MA, Hong DS.. Clin Cancer Res. 2020 Jun 25. doi: 10.1158/1078-0432.CCR-20-0328. Online ahead of print.
Jun 18, 2020
Race and Ethnicity Influence Survival Outcomes in Women of Caribbean Nativity With Epithelial Ovarian Cancer
Schlumbrecht M, Cerbon D, Castillo M, Jordan S, Butler R, Pinto A, George S.. Front Oncol. 2020 May 29;10:880. doi: 10.3389/fonc.2020.00880. eCollection 2020.
Jun 14, 2020
Compressive Stimulation Enhances Ovarian Cancer Proliferation, Invasion, Chemoresistance, and Mechanotransduction via CDC42 in a 3D Bioreactor
Novak CM, Horst EN, Lin E, Mehta G.. Cancers (Basel). 2020 Jun 10;12(6):1521. doi: 10.3390/cancers12061521.
Jun 9, 2020
Utility of serum CA-125 monitoring in patients with ovarian cancer undergoing immune checkpoint inhibitor therapy
Boland JL, Zhou Q, Iasonos AE, O'Cearbhaill RE, Konner J, Callahan M, Friedman C, Aghajanian C, Sabbatini P, Zamarin D, Cadoo KA.. Gynecol Oncol. 2020 Aug;158(2):303-308. doi: 10.1016/j.ygyno.2020.04.710. Epub 2020 Jun 2.
Jun 7, 2020
Safety, immunogenicity, and clinical efficacy of durvalumab in combination with folate receptor alpha vaccine TPIV200 in patients with advanced ovarian cancer: a phase II trial
Zamarin D, Walderich S, Holland A, Zhou Q, Iasonos AE, Torrisi JM, Merghoub T, Chesebrough LF, Mcdonnell AS, Gallagher JM, Li Y, Hollmann TJ, Grisham RN, Erskine CL, Block MS, Knutson KL, O'Cearbhaill RE, Aghajanian C, Konner JA.. J Immunother Cancer. 2020 Jun;8(1):e000829. doi: 10.1136/jitc-2020-000829.
Jun 6, 2020
The associations between physical activity, neuropathy symptoms and health-related quality of life among gynecologic cancer survivors
Thomaier L, Jewett P, Brown K, Gotlieb R, Teoh D, Blaes AH, Argenta P, Vogel RI.. Gynecol Oncol. 2020 Aug;158(2):361-365. doi: 10.1016/j.ygyno.2020.05.026. Epub 2020 Jun 1.
Jun 2, 2020
2056Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
Shivange G, Mondal T, Lyerly E, Gatesman J, Tushir-Singh J.. J Vis Exp. 2020 May 16;(159). doi: 10.3791/60727.
May 31, 2020
Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells
Kang M, Chong KY, Hartwich TMP, Bi F, Witham AK, Patrick D, Morrisson MJ, Cady SL, Cerchia AP, Kelk D, Liu Y, Nucci J, Madarikan O, Ueno D, Shuch BM, Yang-Hartwich Y.. Oncogenesis. 2020 May 29;9(5):55. doi: 10.1038/s41389-020-0243-y.
May 4, 2020
BRCA1 Mutational Complementation Induces Synthetic Viability
Nacson J, Di Marcantonio D, Wang Y, Bernhardy AJ, Clausen E, Hua X, Cai KQ, Martinez E, Feng W, Call?©n E, Wu W, Gupta GP, Testa JR, Nussenzweig A, Sykes SM, Johnson N.. Mol Cell. 2020 Jun 4;78(5):951-959.e6. doi: 10.1016/j.molcel.2020.04.006. Epub 2020 Apr 30.
May 1, 2020
Integrative Transcriptome Analyses of the Human Fallopian Tube: Fimbria and Ampulla-Site of Origin of Serous Carcinoma of the Ovary
Sowamber R, Nelson O, Dodds L, DeCastro V, Paudel I, Milea A, Considine M, Cope L, Pinto A, Schlumbrecht M, Slomovitz B, Shaw PA, George SHL.. Cancers (Basel). 2020 Apr 27;12(5):1090. doi: 10.3390/cancers12051090.
May 1, 2020
Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation
Dasari S, Pandhiri T, Grassi T, Visscher DW, Multinu F, Agarwal K, Mariani A, Shridhar V, Mitra AK.. Mol Cancer Res. 2020 Aug;18(8):1202-1217. doi: 10.1158/1541-7786.MCR-19-1162. Epub 2020 Apr 29.
Apr 22, 2020
Inhibition of the Wnt/B-catenin pathway enhances antitumor immunity in ovarian cancer
Doo DW, Meza-Perez S, Londo?±o AI, Goldsberry WN, Katre AA, Boone JD, Moore DJ, Hudson CT, Betella I, McCaw TR, Gangrade A, Bao R, Luke JJ, Yang ES, Birrer MJ, Starenki D, Cooper SJ, Buchsbaum DJ, Norian LA, Randall TD, Arend RC.. Ther Adv Med Oncol. 2020 Apr 14;12:1758835920913798. doi: 10.1177/1758835920913798. eCollection 2020.
Apr 17, 2020
Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis
Rao W, Wang S, Duleba M, Niroula S, Goller K, Xie J, Mahalingam R, Neupane R, Liew AA, Vincent M, Okuda K, O'Neal WK, Boucher RC, Dickey BF, Wechsler ME, Ibrahim O, Engelhardt JF, Mertens TCJ, Wang W, Jyothula SSK, Crum CP, Karmouty-Quintana H, Parekh KR, Metersky ML, McKeon FD, Xian W.. Cell. 2020 May 14;181(4):848-864.e18. doi: 10.1016/j.cell.2020.03.047. Epub 2020 Apr 15.
Apr 11, 2020
Randomized Phase II Trial of Nivolumab Versus Nivolumab and Ipilimumab for Recurrent or Persistent Ovarian Cancer: An NRG Oncology Study
Zamarin D, Burger RA, Sill MW, Powell DJ Jr, Lankes HA, Feldman MD, Zivanovic O, Gunderson C, Ko E, Mathews C, Sharma S, Hagemann AR, Khleif S, Aghajanian C.. J Clin Oncol. 2020 Jun 1;38(16):1814-1823. doi: 10.1200/JCO.19.02059. Epub 2020 Apr 10.
Apr 9, 2020
Ofranergene obadenovec (VB-111) in platinum-resistant ovarian cancer; favorable response rates in a phase I/II study are associated with an immunotherapeutic effect
Arend RC, Beer HM, Cohen YC, Berlin S, Birrer MJ, Campos SM, Rachmilewitz Minei T, Harats D, Wall JA, Foxall ME, Penson RT.. Gynecol Oncol. 2020 Jun;157(3):578-584. doi: 10.1016/j.ygyno.2020.02.034. Epub 2020 Apr 5.
Apr 3, 2020
Cloning of ground-state intestinal stem cells from endoscopic biopsy samples
Duleba M, Yamamoto Y, Neupane R, Rao W, Xie J, Qi Y, Liew AA, Niroula S, Zhang Y, Mahalingam R, Wang S, Goller K, Ajani JA, Vincent M, Ho KY, Hou JK, Hyams JS, Sylvester FA, Crum CP, McKeon F, Xian W.. Nat Protoc. 2020 May;15(5):1612-1627. doi: 10.1038/s41596-020-0298-4. Epub 2020 Apr 1.
Mar 28, 2020
Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment
Goldsberry WN, Meza-Perez S, Londo?±o AI, Katre AA, Mott BT, Roane BM, Goel N, Wall JA, Cooper SJ, Norian LA, Randall TD, Birrer MJ, Arend RC.. Cancers (Basel). 2020 Mar 24;12(3):766. doi: 10.3390/cancers12030766.
Mar 28, 2020
RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers
Krais JJ, Wang Y, Bernhardy AJ, Clausen E, Miller JA, Cai KQ, Scott CL, Johnson N.. Cancer Res. 2020 Jul 1;80(13):2848-2860. doi: 10.1158/0008-5472.CAN-19-3033. Epub 2020 Mar 25.
Mar 21, 2020
Wnt signaling modulator DKK1 as an immunotherapeutic target in ovarian cancer
Betella I, Turbitt WJ, Szul T, Wu B, Martinez A, Katre A, Wall JA, Norian L, Birrer MJ, Arend R.. Gynecol Oncol. 2020 Jun;157(3):765-774. doi: 10.1016/j.ygyno.2020.03.010. Epub 2020 Mar 16.
Mar 18, 2020
Ectopic RNF168 expression promotes break-induced replication-like DNA synthesis at stalled replication forks
Krais JJ, Johnson N.. Nucleic Acids Res. 2020 May 7;48(8):4298-4308. doi: 10.1093/nar/gkaa154.
Feb 25, 2020
Cancer-Related Distress: Revisiting the Utility of the National Comprehensive Cancer Network Distress Thermometer Problem List in Women With Gynecologic Cancers
Jewett PI, Teoh D, Petzel S, Lee H, Messelt A, Kendall J, Hatsukami D, Everson-Rose SA, Blaes AH, Vogel RI.. JCO Oncol Pract. 2020 Aug;16(8):e649-e659. doi: 10.1200/JOP.19.00471. Epub 2020 Feb 24.
Feb 13, 2020
Large, Non-Cavity Distorting Intramural Leiomyomas Decrease Leukemia Inhibitory Factor in the Secretory Phase Endometrium
Pier B, Crellin C, Katre A, Conner MG, Novak L, Young SL, Arend R.. Reprod Sci. 2020 Feb;27(2):569-574. doi: 10.1007/s43032-019-00056-x. Epub 2020 Jan 1.
Feb 9, 2020
Implementation of a standardized voiding management protocol to reduce unnecessary re-catheterization - A quality improvement project
Brackmann M, Carballo E, Uppal S, Torski J, Reynolds RK, McLean K.. Gynecol Oncol. 2020 May;157(2):487-493. doi: 10.1016/j.ygyno.2020.01.036. Epub 2020 Feb 5.
Feb 1, 2020
Preparation of single cells from tumors for single-cell RNA sequencing
Vijayakumar G, Zamarin D.. Methods Mol Biol. 2020;2058:133-154. doi: 10.1007/978-1-4939-9794-7_9.
Dec 25, 2019
EMR 20006-012: A phase II randomized double-blind placebo controlled trial comparing the combination of pimasertib (MEK inhibitor) with SAR245409 (PI3K inhibitor) to pimasertib alone in patients with previously treated unresectable borderline or low grade
Arend RC, Davis AM, Chimiczewski P, O'Malley DM, Provencher D, Vergote I, Ghamande S, Birrer MJ.. Gynecol Oncol. 2020 Feb;156(2):301-307. doi: 10.1016/j.ygyno.2019.12.002. Epub 2019 Dec 20.
Dec 18, 2019
Sun exposure and protection behaviors in urban and rural long-term melanoma survivors
Jewett PI, Lazovich D, Wehelie H, Boull C, Vogel RI.. Arch Dermatol Res. 2020 Aug;312(6):413-420. doi: 10.1007/s00403-019-02023-7. Epub 2019 Dec 16.
Dec 13, 2019
BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
Wang Y, Bernhardy AJ, Nacson J, Krais JJ, Tan YF, Nicolas E, Radke MR, Handorf E, Llop-Guevara A, Balma?±a J, Swisher EM, Serra V, Peri S, Johnson N.. Nat Commun. 2019 Dec 11;10(1):5661. doi: 10.1038/s41467-019-13530-6.
Dec 5, 2019
Endometrial cancer among a cohort of urban Haitian immigrants
Schlumbrecht M, Bussies P, Huang M, Kobetz E, George S.. World J Clin Oncol. 2019 Oct 24;10(10):340-349. doi: 10.5306/wjco.v10.i10.340.
Nov 16, 2019
Neoadjuvant Treatment With Mullerian-Inhibiting Substance Synchronizes Follicles and Enhances Superovulation Yield
Kano M, Hsu JY, Saatcioglu HD, Nagykery N, Zhang L, Morris Sabatini ME, Donahoe PK, Pepin D.. J Endocr Soc. 2019 Jul 22;3(11):2123-2134. doi: 10.1210/js.2019-00190. eCollection 2019 Nov 1.
Oct 12, 2019
Transcriptome Profiling Reveals Matrisome Alteration as a Key Feature of Ovarian Cancer Progression
Mitra S, Tiwari K, Podicheti R, Pandhiri T, Rusch DB, Bonetto A, Zhang C, Mitra AK. Cancers (Basel). 2019 Oct 9;11(10):1513. doi: 10.3390/cancers11101513.
Oct 6, 2019
S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma
Xiao Y, Zhao H, Tian L, Nolley R, Diep AN, Ernst A, Fuh KC, Miao YR, von Eyben R, Leppert JT, Brooks JD, Peehl DM, Giaccia AJ, Rankin EB. Cancer Res. 2019 Nov 15;79(22):5758-5768. doi: 10.1158/0008-5472.CAN-19-1366. Epub 2019 Oct 4.
Sep 6, 2019
Design and Production of Newcastle Disease Virus for Intratumoral Immunomodulation
Vijayakumar G, Zamarin D.. Methods Mol Biol. 2020;2058:133-154. doi: 10.1007/978-1-4939-9794-7_9.
Aug 21, 2019
Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance.
Ward Rashidi MR, Mehta P, Bregenzer M, Raghavan S, Fleck EM, Horst EN, Harissa Z, Ravikumar V, Brady S, Bild A, Rao A, Buckanovich RJ, Mehta G. Neoplasia. 2019 Aug;21(8):822-836. doi: 10.1016/j.neo.2019.06.005. PMID 31299607
Aug 14, 2019
Differences in breast cancer outcomes amongst Black US-born and Caribbean-born immigrants.
Barreto-Coelho P, Cerbon D, Schlumbrecht M, Parra CM, Hurley J, George SHL. Breast Cancer Res Treat. 2019 Aug 14. doi: 10.1007/s10549-019-05403-9. PMID 31414243
Aug 14, 2019
Subsequent therapies and survival after immunotherapy in recurrent ovarian cancer.
Liu YL, Zhou Q, Iasonos A, Emengo VN, Friedman C, Konner JA, O'Cearbhaill RE, Aghajanian C, Zamarin D. Gynecol Oncol. 2019 Aug 14. pii: S0090-8258(19)31457-X. doi: 10.1016/j.ygyno.2019.08.006. PMID 31421916
Aug 9, 2019
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.
Chong KY, Kang M, Garofalo F, Ueno D, Liang H, Cady S, Madarikan O, Pitruzzello N, Tsai CH, Hartwich TMP, Shuch BM, Yang-Hartwich Y. Mol Pharmacol. 2019 Aug;96(2):168-179. doi: 10.1124/mol.119.116137. PMID 31175180
Aug 6, 2019
Unlimited expansion of intestinal stem cells from a wide range of ages.
Duleba M, Mahalingam R, Liew AA, Qi Y, Neupane R, Vincent M, Agarwal S, Sylvester FA, Hyams JS, Ho KY, Hou JK, McKeon F, Xian W. Integr Mol Med. 2019 Aug;6(4). doi: 10.15761/IMM.1000375. PMID 31463081 (Abstract only)
Jul 19, 2019
IRE1?-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain.
Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramai+E2ah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR. Science. 2019 Jul 19;365(6450). pii: eaau6499. doi: 10.1126/science.aau6499. PMID 31320508
Jul 19, 2019
Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments.
Raghavan S, Mehta P, Xie Y, Lei YL, Mehta G. J Immunother Cancer. 2019 Jul 19;7(1):190. doi: 10.1186/s40425-019-0666-1. PMID 31324218
Jul 17, 2019
Neutrophilia and mortality in women with uterine carcinosarcoma.
Arend R, Van Arsdale A, Gojayev A, Roane BM, Doo D, Leath C, Goldberg GL, Huang G. Int J Gynecol Cancer. 2019 Jul 17. pii: ijgc-2019-000440. doi: 10.1136/ijgc-2019-000440. PMID 31320488. Int J Gynecol Cancer. 2019 Jul 17. pii: ijgc-2019-000440. doi: 10.1136/ijgc-2019-000440. PMID 31320488
Jul 17, 2019
Fluid shear stress stimulates breast cancer cells to display invasive and chemoresistant phenotypes while upregulating PLAU in a 3D bioreactor.
Novak CM, Horst EN, Taylor CC, Liu CZ, Mehta G. Biotechnol Bioeng. 2019 Jul 17. doi: 10.1002/bit.27119. PMID 31317530
Jul 5, 2019
Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells.
Bregenzer ME, Davis C, Horst EN, Mehta P, Novak CM, Raghavan S, Snyder CS, Mehta G. J Vis Exp. 2019 Jul 5;(149). doi: 10.3791/59696. PMID 31329171
Jun 24, 2019
Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility.
Saatcioglu HD, Kano M, Horn H, Zhang L, Samore W, Nagykery N, Meinsohn MC, Hyun M, Suliman R, Poulo J, Hsu J, Sacha C, Wang D, Gao G, Lage K, Oliva E, Morris Sabatini ME, Donahoe PK, Pépin D.
Jun 11, 2019
Morphometric and computational assessments to evaluate neuron survival and maturation within compartmentalized microfluidic devices: The influence of design variation on diffusion-driven nutrient transport.
Dixon AR, Horst EN, Garcia JJ, Ndjouyep-Yamaga PR, Mehta G. Neurosci Lett. 2019 Jun 11;703:58-67. doi: 10.1016/j.neulet.2019.03.025. PMID 30885631
Jun 4, 2019
CCAAT/enhancer binding protein delta (C/EBP?) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma.
2040
Sowamber R, Chehade R, Bitar M, Dodds LV, Milea A, Slomovitz B, Shaw PA, George SHL. EBioMedicine. 2019 Jun;44:261-274. doi: 10.1016/j.ebiom.2019.05.002. PMID 31078521
May 15, 2019
Identifying disparities in germline and somatic testing for ovarian cancer.
Huang M, Kamath P, Schlumbrecht M, Miao F, Driscoll D, Oldak S, Slomovitz B, Koru-Sengul T, George S. Gynecol Oncol. 2019 May;153(2):297-303. doi: 10.1016/j.ygyno.2019.03.007. PMID 30890269
May 10, 2019
Integrated cancer tissue engineering models for precision medicine.
Bregenzer ME, Horst EN, Mehta P, Novak CM, Raghavan S, Snyder CS, Mehta G. PLoS One. 2019 May 10;14(5):e0216564. doi: 10.1371/journal.pone.0216564. PMID 31232694
May 3, 2019
Endometrial cancer outcomes among non-Hispanic US born and Caribbean born black women.
Schlumbrecht M, Huang M, Hurley J, George S. Int J Gynecol Cancer. 2019 May 3. pii: ijgc-2019-000347. doi: 10.1136/ijgc-2019-000347. PMID 31055453
May 1, 2019
Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis.
Natarajan S, Foreman KM, Soriano MI, Rossen NS, Shehade H, Fregoso DR, Eggold JT, Krishnan V, Dorigo O, Krieg AJ, Heilshorn SC, Sinha S, Fuh KC, Rankin EB. Cancer Res. 2019 May 1;79(9):2271-2284. doi: 10.1158/0008-5472.CAN-18-2616. PMID 30862717
Apr 15, 2019
A patient-centered mobile health application to motivate use of genetic counseling among women with ovarian cancer: A pilot randomized controlled trial.
Vogel RI, Niendorf K, Petzel S, Lee H, Teoh D, Blaes AH, Argenta P, Rivard C, Winterhoff B, Lee HY, Geller MA. Gynecol Oncol. 2019 Apr;153(1):100-107. doi: 10.1016/j.ygyno.2019.01.019. PMID 30718125
Apr 12, 2019
Patient satisfaction with patient-provider interactions at time of diagnosis among early stage melanoma survivors - a cross-sectional survey.
Zaffran K, Lazovich D, Boull C, Vogel RI. J Am Acad Dermatol. 2019 Apr 12. pii: S0190-9622(19)30600-0. doi: 10.1016/j.jaad.2019.04.014. PMID 30986476
Mar 20, 2019
Targeting HER2 beyond breast cancer.
Bhatnagar S, Tushir-Singh J. Mol Cell Oncol. 2019 Mar 20;6(3):1571984. doi: 10.1080/23723556.2019.1571984. PMID 31131305
Feb 15, 2019
Early disease progression and treatment discontinuation in patients with advanced ovarian cancer receiving immune checkpoint blockade.
Boland JL, Zhou Q, Martin M, Callahan MK, Konner J, O'Cearbhaill RE, Friedman CF, Tew W, Makker V, Grisham RN, Hensley ML, Zecca N, Iasonos AE, Snyder A, Hyman DM, Sabbatini P, Aghajanian C, Cadoo KA, Zamarin D. Gynecol Oncol. 2019 Feb;152(2):251-258. doi: 10.1016/j.ygyno.2018.11.025. PMID 30470581
Feb 3, 2019
Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth.
McLean K, Tan L, Bolland DE, Coffman LG, Peterson LF, Talpaz M, Neamati N, Buckanovich RJ. Oncogene. 2019 Feb;38(9):1576-1584. doi: 10.1038/s41388-018-0523-6. PMID 30305729
Jan 17, 2019
p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT.
Yang-Hartwich Y, Tedja R, Roberts CM, Goodner-Bingham J, Cardenas C, Gurea M, Sumi NJ, Alvero AB, Glackin CA, Mor G. Mol Cancer Res. 2019 Jan;17(1):153-164. doi: 10.1158/1541-7786.MCR-18-0238. PMID 30131448
Jan 15, 2019
An Efficient Method for Cloning Gastrointestinal Stem Cells from Patients via Endoscopic Biopsies.
Duleba M, Qi Y, Mahalingam R, Flynn K, Rinaldi F, Liew AA, Neupane R, Vincent M, Crum CP, Ho KY, Hou JK, Hyams JS, Sylvester FA, McKeon F, Xian W. Gastroenterology. 2019 Jan;156(1):20-23. doi: 10.1053/j.gastro.2018.08.062. PMID 30296437
Jan 11, 2019
Evaluation of graphic messages to promote human papillomavirus vaccination among young adults: A statewide cross-sectional survey.
Teoh D, Shaikh R, Schnaith A, Lou E, McRee AL, Nagler RH, Vogel RI. Prev Med Rep. 2019 Jan 11;13:256-261. doi: 10.1016/j.pmedr.2019.01.002. PMID 30723659
Dec 20, 2018
The DEK Oncoprotein Functions in Ovarian Cancer Growth and Survival.
Hacker KE, Bolland DE, Tan L, Saha AK, Niknafs YS, Markovitz DM, McLean K. Neoplasia. 2018 Dec;20(12):1209-1218. doi: 10.1016/j.neo.2018.10.005. PMID 30412857
Dec 15, 2018
The antitumor effects of entinostat in ovarian cancer require adaptive immunity.
Smith HJ, McCaw TR, Londono AI, Katre AA, Meza-Perez S, Yang ES, Forero A, Buchsbaum DJ, Randall TD, Straughn JM Jr, Norian LA, Arend RC. Cancer. 2018 Dec 15;124(24):4657-4666. doi: 10.1002/cncr.31761 PMID 30423192
Oct 6, 2018
A clinically structured and partnered approach to genetic testing in Trinidadian women with breast cancer and their families
Donenberg T, George S, Ali J, Bravo G, Hernandez K, Sookar N, Ashing KT, Narod SA, Akbari MR, Hurley J. Breast Cancer Res Treat. 2019 Apr;174(2):469-477. doi: 10.1007/s10549-018-5045-y. Epub 2018 Dec 4.
Oct 5, 2018
IRE1?-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
Song M, Sandoval TA, Chae CS, Chopra S, Tan C, Rutkowski MR, Raundhal M, Chaurio RA, Payne KK, Konrad C, Bettigole SE, Shin HR, Crowley MJP, Cerliani JP, Kossenkov AV, Motorykin I, Zhang S, Manfredi G, Zamarin D, Holcomb K, Rodriguez PC, Rabinovich GA, Conejo-Garcia JR, Glimcher LH, Cubillos-Ruiz JR. Nature. 2018 Oct;562(7727):423-428. doi: 10.1038/s41586-018-0597-x. PMID 30305738
Sep 25, 2018
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N. Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086. PMID 30257212
Aug 28, 2018
A Proximal Culture Method to Study Paracrine Signaling Between Cells.
Dasari S, Pandhiri T, Haley J, Lenz D, Mitra AK. J Vis Exp. 2018 Aug 28;(138). doi: 10.3791/58144. PMID 30222146
Aug 13, 2018
1ffcA Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer.
Shivange G, Urbanek K, Przanowski P, Perry JSA, Jones J, Haggart R, Kostka C, Patki T, Stelow E, Petrova Y, Llaneza D, Mayo M, Ravichandran KS, Landen CN, Bhatnagar S, Tushir-Singh J. Cancer Cell. 2018 Aug 13;34(2):331-345.e11. doi: 10.1016/j.ccell.2018.07.005. PMID 30107179
Jul 19, 2018
Lysis-independent potentiation of immune checkpoint blockade by oncolytic virus
Oseledchyk A, Ricca JM, Gigoux M, Ko B, Redelman-Sidi G, Walther T, Liu C, Iyer G, Merghoub T, Wolchok JD, Zamarin D. Oncotarget. 2018 Jun 19;9(47):28702-28716. doi: 10.18632/oncotarget.25614. PMID 29983890
Jul 4, 2018
A qualitative study of barriers to genetic counseling and potential for mobile technology education among women with ovarian cancer.
Vogel RI, Niendorf K, Lee H, Petzel S, Lee HY, Geller MA. Hered Cancer Clin Pract. 2018 Jul 4;16:13. doi: 10.1186/s13053-018-0095-z. PMID 29997716
Jul 1, 2018
Immune-Active Microenvironment in Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Rationale for Immune Checkpoint Blockade
Jelinic P, Ricca J, Van Oudenhove E, Olvera N, Merghoub T, Levine DA, Zamarin D. J Natl Cancer Inst. 2018 Jul 1;110(7):787-790. doi: 10.1093/jnci/djx277. PMID 29365144
Jun 29, 2018
Effect of intra-operative glove changing during cesarean section on post-operative complications: a randomized controlled trial.
Scrafford JD, Reddy B, Rivard C, Vogel RI. Arch Gynecol Obstet. 2018 Jun;297(6):1449-1454. doi: 10.1007/s00404-018-4748-y. PMID 29556706
Jun 1, 2018
Tissue Tranglutaminase Regulates Interactions between Ovarian Cancer Stem Cells and the Tumor Niche.
Condello, Salvatore et al. J Biol Chem vol. 298,8 Aug. 2022; 102242. doi:10.1016/j.jbc.2022.102242
May 16, 2018
Molecular Response to Neoadjuvant Chemotherapy in High-Grade Serous Ovarian Carcinoma.
Arend RC, Londoño AI, Montgomery AM, Smith HJ, Dobbin ZC, Katre AA, Martinez A, Yang ES, Alvarez RD, Huh WK, Bevis KS, Straughn JM Jr, Estes JM, Novak L, Crossman DK, Cooper SJ, Landen CN, Leath CA 3rd. Mol Cancer Res. 2018 May;16(5):813-824. doi: 10.1158/1541-7786.MCR-17-0594 PMID 29523763
Apr 4, 2018
Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy
Ricca JM, Oseledchyk A, Walther T, Liu C, Mangarin L, Merghoub T, Wolchok JD, Zamarin D. Mol Ther. 2018 Apr 4;26(4):1008-1019. doi: 10.1016/j.ymthe.2018.01.019. PMID 29478729
Apr 2, 2018
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy
Zamarin D, Ricca JM, Sadekova S, Oseledchyk A, Yu Y, Blumenschein WM, Wong J, Gigoux M, Merghoub T, Wolchok JD. J Clin Invest. 2018 Apr 2;128(4):1413-1428. doi: 10.1172/JCI98047. PMID 29504948
Mar 7, 2018
Insulin-like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma.
Van Arsdale AR, Arend RC, Cossio MJ, Erickson BK, Wang Y, Doo DW, Leath CA, Goldberg GL, Huang GS. Cancer Med. 2018 Mar;7(3):616-625. doi: 10.1002/cam4.1335 PMID 29455465
Feb 1, 2018
ETS1 induction by the microenvironment promotes ovarian cancer metastasis through focal adhesion kinase.
Tomar S, Plotnik JP, Haley J, Scantland J, Dasari S, Sheikh Z, Emerson R, Lenz D, Hollenhorst PC, Mitra AK. Cancer Lett. 2018 Feb 1;414:190-204. doi: 10.1016/j.canlet.2017.11.012. PMID 29174800
Nov 15, 2017
Personalized Medicine-Based Approach to Model Patterns of Chemoresistance and Tumor Recurrence Using Ovarian Cancer Stem Cell Spheroids.
Raghavan S, Mehta P, Ward MR, Bregenzer ME, Fleck EMA, Tan L, McLean K, Buckanovich RJ, Mehta G. Clin Cancer Res. 2017 Nov 15;23(22):6934-6945. doi: 10.1158/1078-0432.CCR-17-0133. PMID 28814433
Jul 26, 2017
Comparison of quality of life among long-term melanoma survivors and non-melanoma controls: a cross-sectional study.
Vogel RI, Strayer LG, Engelman L, Nelson HH, Blaes AH, Anderson KE, Lazovich D. Qual Life Res. 2017 Jul;26(7):1761-1766. doi: 10.1007/s11136-017-1532-6. PMID 28243994
Jul 4, 2017
Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth.
Turner TB, Meza-Perez S, Londoño A, Katre A, Peabody JE, Smith HJ, Forero A, Norian LA, Straughn JM Jr, Buchsbaum DJ, Randall TD, Arend RC. Oncotarget. 2017 Jul 4;8(27):44159-44170. doi: 10.18632/oncotarget.17395. PMID 28498806
Jun 27, 2017
Elevated tumor mutational burden and prolonged clinical response to anti-PD-L1 antibody in platinum-resistant recurrent ovarian cancer.
Morse CB, Elvin JA, Gay LM, Liao JB. Gynecol Oncol Rep. 2017 Jun 27;21:78-80. doi: 10.1016/j.gore.2017.06.013. Gynecol Oncol Rep. 2017 Jun 27;21:78-80. doi: 10.1016/j.gore.2017.06.013. PMID 28736741
Apr 26, 2017
Sun Exposure and Protection Behaviors among Long-term Melanoma Survivors and Population Controls.
Vogel RI, Strayer LG, Engelman L, Nelson HH, Blaes AH, Anderson KE, Lazovich D. Cancer Epidemiol Biomarkers Prev. 2017 Apr;26(4):607-613. doi: 10.1158/1055-9965.EPI-16-0854. PMID 28254810
Mar 2, 2017
Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.
Li J, Condello S, Thomes-Pepin J, Ma X, Xia Y, Hurley TD, Matei D, Cheng JX. Cell Stem Cell. 2017 Mar 2;20(3):303-314.e5. doi: 10.1016/j.stem.2016.11.004. PMID 28041894
Mar 1, 2017
Phase II trial of albumin-bound paclitaxel and granulocyte macrophage colony-stimulating factor as an immune modulator in recurrent platinum resistant ovarian cancer.
Liao JB, Swensen RE, Ovenell KJ, Hitchcock-Bernhardt KM, Reichow JL, Apodaca MC, D'Amico L, Childs JS, Higgins DM, Buening BJ, Goff BA, Disis ML. Gynecol Oncol. 2017 Mar;144(3):480-485. doi: 10.1016/j.ygyno.2017.01.008. PMID 28089377
Feb 28, 2017
AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy.
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Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N, Sabatini ME, Gao G, Donahoe PK, Pépin D. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1688-E1697. doi: 10.1073/pnas.1620729114. PMID 28137855
Feb 13, 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Zamarin D, Holmgaard RB, Ricca J, Plitt T, Palese P, Sharma P, Merghoub T, Wolchok JD, Allison JP. Nat Commun. 2017 Feb 13;8:14340. doi: 10.1038/ncomms14340. PMID 28194010
Jan 15, 2017
In Vitro Assay to Study Histone Ubiquitination During Transcriptional Regulation.
Tushir-Singh J, Bhatnagar S. Methods Mol Biol. 2017;1507:235-244. PMID 27832544
Dec 27, 2016
Niclosamide and its analogs are potent inhibitors of Wnt/?-catenin, mTOR and STAT3 signaling in ovarian cancer.
Arend RC, Londoño-Joshi AI, Gangrade A, Katre AA, Kurpad C, Li Y, Samant RS, Li PK, Landen CN, Yang ES, Hidalgo B, Alvarez RD, Straughn JM, Forero A, Buchsbaum DJ. Oncotarget. 2016 Dec 27;7(52):86803-86815. doi: 10.18632/oncotarget. PMID 27888804
Oct 15, 2016
VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal
Bastola P, Neums L, Schoenen FJ, Chien J. VCP inhibitors induce endoplasmicreticulum stress, cause cell cycle arrest, trigger caspase-mediated celldeath and synergistically kill ovarian cancer cells in combination withSalubrinal. Mol Oncol. 2016 Sep 28. pii: S1574-7891(16)30104-1. doi:10.1016/j.molonc.2016.09.005. PubMed PMID: 27729194.
Sep 13, 2016
BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression
Zhu H, Bengsch F, Svoronos N, Rutkowski MR, Bitler BG, Allegrezza MJ, Yokoyama Y, Kossenkov AV, Bradner JE, Conejo-Garcia JR, Zhang R. BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression. Cell Rep. 2016 Sep 13;16(11):2829-37. doi: 10.1016/j.celrep.2016.08.032. PubMed PMID: 27626654.
Aug 2, 2016
Primary Peritoneal Carcinoma in a BRCA1/2-negative, PALB2-positive patient.
Kahn R, Garcia-Soto A, Silva-Smith R, Pinto A, George SH. Gynecol Oncol Rep. 2016 Aug 2;17:93-5. doi: 10.1016/j.gore.2016.08.001. PMID 27547810
Aug 1, 2016
RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance.
Wang Y, Krais JJ, Bernhardy AJ, Nicolas E, Cai KQ, Harrell MI, Kim HH, George E, Swisher EM, Simpkins F, Johnson N. J Clin Invest. 2016 Aug 1;126(8):3145-57. doi: 10.1172/JCI87033. PMID 27454289
Jun 2, 2016
CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.
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