Functional and Metabolic Imaging Group
Xenon Imaging in Small and Large Animals
Xenon Imaging of a Transplant Recipient
A: Hybrid imaging to measure Fractional Ventilation, T1 and ADC in a unilateral lung transplant subject and the spin density maps of the 6th breath from the multibreath maneuver. B: The same in a healthy subject and, C: In a bilateral lung transplant patient for comparison. ... Read More
Dissolved Phase Xenon Imaging
Magnetic Resonance Imaging of Hyperpolarized 129Xe Gas in the Lung Airways (left) and 129Xe Dissolved Phase (right) in the lung parenchyma, which can also be visualized in the aortic arch, heart, kidneys, liver, intestine, limbs and peripheral tissues... Read More
Functional Imaging of a COPD Patient
A: Schematic depiction of multi-breath sequence in a COPD subject, yielding local SV, flip-angle and PAO2. Note the gradual filling of the medial right lung (yellow circles), indicating reduced SV, corresponding to the region of air trapping depicted in images 11-13. B: 2-D representations of the 3-D PRM used to classify COPD subjects, adapted for use in 129Xe based on healthy nonsmoker, asymptomatic smokers and COPD patients. ... Read More
Metabolic Imaging of Injured Porcine Lung
Hyperpolarized 13C Imaging of porcine lungs after 6 hours of acid instillation injury. Data was acquired using an 8-channel flex vest coil and images were reconstructed from the 4 posterior channels. Metabolic maps show increased enhanced lactate production in posterior lung as a result of progressed inflammatory injury.... Read More
Real-Time Metabolic Profiling of Cancer
T2-weighted axial scan over the lungs, showing the primary tumor in the lung and the secondary tumor protruding out of the thoracic cavity. Metabolite maps are overlaid on the T2 scan, and the lactate map shows enhanced lactate signal over both primary and secondary tumors (white arrows). 13C spectra averaged over the non-cancerous lung tissue next to the tumor (A), the primary tumor (B) and the secondary tumor (C) are shown on the right. The spectra show elevated lactate-to-pyruvate ratio over the tumors relative to the lung tissue.
High resolution multi-slice imaging of porcine lung perfusion after administration of hyperpolarized [1-13C] pyruvate maps using a single-shot fast-spin-echo pulse sequence.
The Functional and Metabolic Imaging Group (FMIG) focuses on developing novel hyperpolarized MRI techniques for the diagnoses and monitoring of a variety of pulmonary and metabolic disorders. Specifically, the FMIG’s research activities can be divided into three general branches:
1. The development of novel hyperpolarized gas (3He and 129Xe) MR imaging techniques for the quantitative assessment of pulmonary structure and function.
2. The development of real-time metabolic imaging techniques to investigate the use of hyperpolarized 13C-labeled metabolites (e.g. [1-13C]pyruvate) to assess lung perfusion and pulmonary pH, as well as to detect aberrant metabolism, which is a key pathological indication for a number of disease states, including lung transplant rejection and cancer.
3. The development and implementation of rapid imaging pulse sequences to optimize hyperpolarized MRI data acquisition.