FMIG Functional and Metabolic Imaging Group

  • Image processing pipeline for monitoring treatment response of Endobronchial valve (EBV) surgery

    Image processing pipeline for monitoring treatment response of Endobronchial valve (EBV) surgery

  • Xenon Imaging of a Transplant Recipient

    Xenon Imaging of a Transplant Recipient

    A: Hybrid imaging to measure Fractional Ventilation, T1 and ADC in a unilateral lung transplant subject and the spin density maps of the 6th breath from the multibreath maneuver. B: The same in a healthy subject and, C: In a bilateral lung transplant patient for comparison. ... Read More

  • Rat lung transplantation

    Rat lung transplantation

  • Functional Imaging of a COPD Patient

    Functional Imaging of a COPD Patient

    A: Schematic depiction of multi-breath sequence in a COPD subject, yielding local SV, flip-angle and PAO2. Note the gradual filling of the medial right lung (yellow circles), indicating reduced SV, corresponding to the region of air trapping depicted in images 11-13. B: 2-D representations of the 3-D PRM used to classify COPD subjects, adapted for use in 129Xe based on healthy nonsmoker, asymptomatic smokers and COPD patients. ... Read More

  • Comparison of Wash-in/Wash-out & FV in rat

    Comparison of Wash-in/Wash-out & FV in rat

  • C13 Haste

    C13 Haste

    High resolution multi-slice imaging of porcine lung perfusion after administration of hyperpolarized [1-13C] pyruvate maps using a single-shot fast-spin-echo pulse sequence.

  • xenon-polarization transfer contrast (XTC) MRI

    xenon-polarization transfer contrast (XTC) MRI

About

The Functional and Metabolic Imaging Group (FMIG) focuses on developing novel hyperpolarized MRI techniques for the diagnoses and monitoring of a variety of pulmonary and metabolic disorders. Specifically, the FMIG’s research activities can be divided into three general branches:

1.     The development of novel hyperpolarized gas (3He and 129Xe) MR imaging techniques for the quantitative assessment of pulmonary structure and function. 

2.     The development of real-time metabolic imaging techniques to investigate the use of hyperpolarized 13C-labeled metabolites (e.g. [1-13C]pyruvate) to assess lung perfusion and pulmonary pH, as well as to detect aberrant metabolism, which is a key pathological indication for a number of disease states, including lung transplant rejection and cancer. 

3.     The development and implementation of rapid imaging pulse sequences to optimize hyperpolarized MRI data acquisition.

News & Announcements

  • January 28, 2019

    The 2019 International Workshop on Pulmonary Imaging is scheduled for February 28-March 2, 2019

  • September 12, 2018

    Postdoctoral and graduate student positions are available. Please send your CV to fmig@pennmedicine.upenn.edu

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