Craig H. Bassing, PhD

Professor of Pathology and Laboratory Medicine

Member, Abramson Cancer Center - Pediatric Oncology Research
Member, Institute for Immunology
Member, Division of Cancer Pathobiology, Children's Hospital of Philadelphia, University of Pennsylvania
Member, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania
Investigator, Abramson Family Cancer Research Institute

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Contact Information

Children's Hospital of Philadelphia
4054 Colket Translational Research Building
3501 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-0311
Fax: 267-426-2791
Email: bassing@pennmedicine.upenn.edu

I3H Keywords

Immune System Development and Function in Host Homeostasis
Systems Immunology and Genomics

Education

B.A. (Biology)
The Johns Hopkins University, 1992
Ph.D. (Biology)
Duke University, 1997

Post-Graduate Training

Research Fellow in Molecular Immunology
Irvington Institute for Immunological Research, 1997 - 2000
Research Fellow in Cancer Genetics
Lymphoma Research Foundation, 2003 - 2005
Research Fellow in Molecular Immunology
CBR Institute for Biomedical Research , 1997 - 2000
Research Fellow in Genetics
Harvard Medical School, 1997 - 2002
Research Fellow in Medicine
Boston Children's Hospital, 1997 - 2002
Research Associate in Molecular Immunology
Howard Hughes Medical Institute, 2000 - 2003

Selected Publications

Glynn, R.A. and Bassing, C.H. : ATM-Dependent Phosphorylation of Nemo SQ Motifs is Dispensable for Nemo-Mediated Gene Expression Changes in Response to DNA Double Strand Breaks The Journal of Immunology In Press 2024
Allyn, B.M., Hayer, K.E., Oyeniran, C., Nganga, V., Lee, K., Mishra, B., Sacan, A., Oltz, E.M., and Bassing, C.H. : Locus Folding Mechanisms Determine Modes of Antigen Receptor Gene Assembly The Journal of Experimental Medicine 221 2024
Culberson, E.J., Shields, K.C., Glynn, R.A., Allyn, B.M., Hayer, K.E., and Bassing, C.H. : The Cyclin D3 Protein Enforces Monogenic TCRb Expression by Mediating TCRb Protein Signaled Feedback Inhibition of Vb Recombination The Journal of Immunology 212 2024
Burn, T.N., Miot, C., Gordon, S.M., Culberson, E.J., Diamond, T., Kreiger, P.A., Hayer, K.E., Bhattacharyya, A., Jones, J.M., Bassing, C.H.*, and Behrens, E.M.* *Co-corresponding authors : The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRb and a Genes and Influences Development of ab T Cell Lineages The Journal of Immunology 209 2022
Glynn, R.A. and Bassing, C.H. : Nemo-dependent, ATM-mediated signals from RAG DNA breaks at Igk feedback inhibit Vk recombination to enforce Igκ allelic exclusion The Journal of Immunology 208 : 371-383, 2022
Wu, G., Culberson, E.J., Allyn, B.M., and Bassing, C.H. : Poor-Quality Vb Recombination Signal Sequences and the DNA Damage Response ATM Kinase Collaborate to Establish TCRb Gene Repertoire and Allelic Exclusion The Journal of Immunology doi: 10.4049/jimmunol.2100489 2022
Culberson, E.J. and Bassing, C.H. : Monogenic TCRb Assembly and Expression is Paramount for Uniform Antigen Receptor Specificity of Individual ab T Lymphocytes The Journal of Immunology 209 2022
Beilinson, H.A., Glynn, R.A., Yadavailli, A.D., Xiao, J., Corbett, E., Saribasak, H., Arya, R., Miot, C., Bhattacharyya, A., Jones, J.M., Pongubala, J., Bassing, C.H., and Schatz, D.G. : The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination. Journal of Experimental Medicine 218(10) : :e20210250, 2021
Dauphers, D.J., Wu, G.S., Bassing, C.H., and Krangel, M.S. : Molecular Analysis of Mouse T Cell Receptor α and β Gene Rearrangements Methods in Molecular Biology In Press 2021
Burn, Thomas, N., Lee, Kyutae, D., Dawany, N., Robertson, Tanner, F., Fisher, Megan, R., Bassing, Craig H., and Behrens, Edward M. : A Spontaneous Rag1 Nonsense Mutations Unveils Naturally Occurring N-truncated RAG1 Isoforms ImmunoHorizons 4 : 119-128, 2020