Human Metabolism Resource

The Human Metabolism Resource aims to provide consultation and services to IDOM investigators in the conduct of metabolic tests specifically relevant to diabetes, obesity and related metabolic disorders. The clinical expertise of a diabetes research nurse practitioner is available for assessing insulin secretion and sensitivity by numerous methodologies including the glucose-potentiated arginine (GPA) test, the frequently-sampled intravenous glucose tolerance (FSIGT) test, and the hyperinsulinemic euglycemic clamp conducted in the Center for Human Phenomic Science (CHPS – former CTRC). Metabolic tracers can be incorporated into glucose clamp studies and analyzed by the Metabolic Tracer Resource. Assistance with mathematical modeling of beta-cell sensitivity to glucose derived from the GPA test, insulin sensitivity derived from the FSIGT test, and rates of glucose production and disposal derived from glucose clamp studies with isotope tracers is also available. Finally, investigators requiring access to patients with diabetes for continuous glucose monitoring, genetic or other samples can receive support for their studies via the clinical research laboratory located in the Rodebaugh Diabetes Center.