Archived Publications

2023

June

Effector memory CD8 T-cells as a novel peripheral blood biomarker for activated T-cell pediatric acute liver failure . Chapin CA, Burn TM, Diamond T, Loomes KM, Alonso EM, Behrens EM. PLoS One. 2023 Jun 2;18(6):e0286394. doi: 10.1371/journal.pone.0286394. eCollection 2023.PMID: 37267251
In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy. Guimarães PPG, Figueroa-Espada CG, Riley RS, Gong N, Xue L, Sewastianik T, Dennis PS, Loebel C, Chung A, Shepherd SJ, Haley RM, Hamilton AG, El-Mayta R, Wang K, Langer R, Anderson DG, Carrasco RD, Mitchell MJ. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2215711120. doi: 10.1073/pnas.2215711120. Epub 2023 Jun 13. PMID: 37310997
Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes. Sun Y, Young MC, Woodward CH, Danon JN, Truong HV, Gupta S, Winters TJ, Font-Burgada J, Burslem GM, Sgourakis NG. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2304055120. doi: 10.1073/pnas.2304055120. Epub 2023 Jun 13. PMID: 37310998
The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8⁺ T cells. Baxter AE, Huang H, Giles JR, Chen Z, Wu JE, Drury S, Dalton K, Park SL, Torres L, Simone BW, Klapholz M, Ngiow SF, Freilich E, Manne S, Alcalde V, Ekshyyan V, Berger SL, Shi J, Jordan MS, Wherry EJ. Immunity. 2023 Jun 13;56(6):1320-1340.e10. doi: 10.1016/j.immuni.2023.05.008. PMID: 37315535
The enteric nervous system relays psychological stress to intestinal inflammation. Schneider KM, Blank N, Alvarez Y, Thum K, Lundgren P, Litichevskiy L, Sleeman M, Bahnsen K, Kim J, Kardo S, Patel S, Dohnalová L, Uhr GT, Descamps HC, Kircher S, McSween AM, Ardabili AR, Nemec KM, Jimenez MT, Glotfelty LG, Eisenberg JD, Furth EE, Henao-Mejia J, Bennett FC, Pierik MJ, Romberg-Camps M, Mujagic Z, Prinz M, Schneider CV, Wherry EJ, Bewtra M, Heuckeroth RO, Levy M, Thaiss CA. Cell. 2023 Jun 22;186(13):2823-2838.e20. doi: 10.1016/j.cell.2023.05.001. Epub 2023 May 25. PMID: 37236193
The enteric nervous system relays psychological stress to intestinal inflammation. Schneider KM, Blank N, Alvarez Y, Thum K, Lundgren P, Litichevskiy L, Sleeman M, Bahnsen K, Kim J, Kardo S, Patel S, Dohnalová L, Uhr GT, Descamps HC, Kircher S, McSween AM, Ardabili AR, Nemec KM, Jimenez MT, Glotfelty LG, Eisenberg JD, Furth EE, Henao-Mejia J, Bennett FC, Pierik MJ, Romberg-Camps M, Mujagic Z, Prinz M, Schneider CV, Wherry EJ, Bewtra M, Heuckeroth RO, Levy M, Thaiss CA. Cell. 2023 Jun 22;186(13):2823-2838.e20. doi: 10.1016/j.cell.2023.05.001. Epub 2023 May 25. PMID: 37236193
CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity. Sullivan KMC, Vilalta M, Ertl LS, Wang Y, Dunlap C, Ebsworth K, Zhao BN, Li S, Zeng Y, Miao Z, Fan P, Mali V, Lange C, McMurtrie D, Yang J, Lui R, Scamp R, Chhina V, Kumamoto A, Yau S, Dang T, Easterday A, Liu S, Miao S, Charo I, Schall TJ, Zhang P. PLoS One. 2023 Jun 7;18(6):e0286724. doi: 10.1371/journal.pone.0286724. eCollection 2023. PMID: 37285333
Survival of Patients With Neuroblastoma After Assignment to Reduced Therapy Because of the 12- to 18-Month Change in Age Cutoff in Children's Oncology Group Risk Stratification. Bender HG, Irwin MS, Hogarty MD, Castleberry R, Maris JM, Kao PC, Zhang FF, Naranjo A, Cohn SL, London WB. J Clin Oncol. 2023 Jun 10;41(17):3149-3159. doi: 10.1200/JCO.22.01946. Epub 2023 Apr 25. PMID: 37098238
Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization. Chen YH, Yeung F, Lacey KA, Zaldana K, Lin JD, Bee GCW, McCauley C, Barre RS, Liang SH, Hansen CB, Downie AE, Tio K, Weiser JN, Torres VJ, Bennett RJ, Loke P, Graham AL, Cadwell K. Sci Immunol. 2023 Jun 23;8(84):eadd6910. doi: 10.1126/sciimmunol.add6910. Epub 2023 Jun 23. PMID: 37352372

May

Sexual dimorphism in the response to chronic circadian misalignment on a high-fat diet. Anderson ST, Meng H, Brooks TG, Tang SY, Lordan R, Sengupta A, Nayak S, Mřela A, Sarantopoulou D, Lahens NF, Weljie A, Grant GR, Bushman FD, FitzGerald GA. Sci Transl Med. 2023 May 17;15(696):eabo2022. doi: 10.1126/scitranslmed.abo2022. Epub 2023 May 17. PMID: 37196066
Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors Jung IY, Noguera-Ortega E, Bartoszek R, Collins SM, Williams E, Davis M, Jadlowsky JK, Plesa G, Siegel DL, Chew A, Levine BL, Berger SL, Moon EK, Albelda SM, Fraietta JA. Cell Rep Med. 2023 May 16:101053. doi: 10.1016/j.xcrm.2023.101053. Online ahead of print. PMID: 37224816
IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, Haltzman BL, Gianchetti L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel JM, Tanes C, Bittinger K, Henrickson SE, Silverman MA. Sci Immunol. 2023 May 26;8(83):eade2335. doi: 10.1126/sciimmunol.ade2335. Epub 2023 May 26. PMID: 37235682
Single cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality. Shi T, Burg AR, Caldwell JT, Roskin KM, Castro-Rojas CM, Chukwuma PC, Gray GI, Foote SG, Alonso JA, Cuda CM, Allman DA, Rush JS, Regnier CH, Wieczorek G, Alloway RR, Shields AR, Baker BM, Woodle ES, Hildeman DA. J Clin Invest. 2023 May 25:e170191. doi: 10.1172/JCI170191. Online ahead of print. PMID: 37227784
A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8. Rodriguez-Rodriguez BA, Ciabattoni GO, Duerr R, Valero-Jimenez AM, Yeung ST, Crosse KM, Schinlever AR, Bernard-Raichon L, Rodriguez Galvan J, McGrath ME, Vashee S, Xue Y, Loomis CA, Khanna KM, Cadwell K, Desvignes L, Frieman MB, Ortigoza MB, Dittmann M. Nat Commun. 2023 May 25;14(1):3026. doi: 10.1038/s41467-023-38783-0. PMID: 37230979
The enteric nervous system relays psychological stress to intestinal inflammation. Schneider KM, Blank N, Alvarez Y, Thum K, Lundgren P, Litichevskiy L, Sleeman M, Bahnsen K, Kim J, Kardo S, Patel S, Dohnalová L, Uhr GT, Descamps HC, Kircher S, McSween AM, Ardabili AR, Nemec KM, Jimenez MT, Glotfelty LG, Eisenberg JD, Furth EE, Henao-Mejia J, Bennett FC, Pierik MJ, Romberg-Camps M, Mujagic Z, Prinz M, Schneider CV, Wherry EJ, Bewtra M, Heuckeroth RO, Levy M, Thaiss CA. Cell. 2023 May 22:S0092-8674(23)00475-0. doi: 10.1016/j.cell.2023.05.001. Online ahead of print. PMID: 37236193
SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19 . Rybkina K, Bell JN, Bradley MC, Wohlbold T, Scafuro M, Meng W, Korenberg RC, Davis-Porada J, Anderson BR, Weller RJ, Milner JD, Moscona A, Porotto M, Luning Prak ET, Pethe K, Connors TJ, Farber DL. J Exp Med. 2023 Aug 7;220(8):e20221518. doi: 10.1084/jem.20221518. Epub 2023 May 3. PMID: 37133746
STAT3 signaling in B cells controls germinal center zone organization and recycling. Fike AJ, Chodisetti SB, Wright NE, Bricker KN, Domeier PP, Maienschein-Cline M, Rosenfeld AM, Luckenbill SA, Weber JL, Choi NM, Luning Prak ET, Mandal M, Clark MR, Rahman ZSM. Cell Rep. 2023 May 30;42(5):112512. doi: 10.1016/j.celrep.2023.112512. Epub 2023 May 16. PMID: 37200190
PI16⁺ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches . De Martin A, Stanossek Y, Lütge M, Cadosch N, Onder L, Cheng HW, Brandstadter JD, Maillard I, Stoeckli SJ, Pikor NB, Ludewig B. Nat Immunol. 2023 May 18. doi: 10.1038/s41590-023-01502-4. Online ahead of print. PMID: 37202490
Exosome-disrupting peptides for cancer immunotherapy. Gong N, Hamilton AG, Mitchell MJ. Nat Mater. 2023 May;22(5):530-531. doi: 10.1038/s41563-023-01525-0. PMID: 36991148
Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation. Chandra A, Yoon S, Michieletto MF, Goldman N, Ferrari EK, Abedi M, Johnson I, Fasolino M, Pham K, Joannas L, Kee BL, Henao-Mejia J, Vahedi G. Immunity.2023 May 31:S1074-7613(23)00221-2. doi: 10.1016/j.immuni.2023.05.004. Online ahead of print. PMID: 37263273
Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality. Dang MT, Gonzalez MV, Gaonkar KS, Rathi KS, Young P, Arif S, Zhai L, Alam Z, Devalaraja S, Jerrick To TK, Folkert IW, Raman P, Rokita JL, Martinez D, Taroni JN, Shapiro JA, Greene CS, Savonen C, Mafra F, Hakonarson H, Curran T, Haldar M. Cell Rep. 2023 May 25;42(6):112600. doi: 10.1016/j.celrep.2023.112600. Online ahead of print. PMID: 37235472

April

Efficient engineering of human and mouse primary cells using peptide-assisted genome editing. Zhang Z, Baxter AE, Ren D, Qin K, Chen Z, Collins SM, Huang H, Komar CA, Bailer PF, Parker JB, Blobel GA, Kohli RM, Wherry EJ, Berger SL, Shi J. Nat Biotechnol. 2023 Apr 24. doi: 10.1038/s41587-023-01756-1. Online ahead of print. PMID: 37095348
Human T follicular helper clones seed the germinal center-resident regulatory pool. Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, Wherry EJ, Gonzalez M, Romberg N. Sci Immunol. 2023 Apr 14;8(82):eade8162. doi: 10.1126/sciimmunol.ade8162. Epub 2023 Apr 7. PMID: 37027481
Inflammatory monocytes promote granuloma control of Yersinia infection. Sorobetea D, Matsuda R, Peterson ST, Grayczyk JP, Rao I, Krespan E, Lanza M, Assenmacher CA, Mack M, Beiting DP, Radaelli E, Brodsky IE. Nat Microbiol. 2023 Apr;8(4):666-678. doi: 10.1038/s41564-023-01338-6. Epub 2023 Mar 6. PMID: 36879169
Crosstalk between skin microbiota and immune system in health and disease. Liu Q, Ranallo R, Rios C, Grice EA, Moon K, Gallo RL. Nat Immunol.2023 Apr 20. doi: 10.1038/s41590-023-01500-6. Online ahead of print. PMID: 37081151
A miRNA/CXCR4 signaling axis impairs monopoiesis and angiogenesis in diabetic critical limb ischemia . Cheng HS, Zhuang R, Pérez-Cremades D, Chen J, Jamaiyar A, Wu W, Sausen G, Tzani A, Plutzky J, Henao-Mejia J, Goodney PP, Creager MA, Sabatine MS, Bonaca MP, Feinberg MW. JCI Insight. 2023 Apr 10;8(7):e163360. doi: 10.1172/jci.insight.163360. PMID: 36821386
Distinct stage-specific transcriptional states of B cells derived from human tonsillar tissue . Espinoza DA, Le Coz C, Cruz Cabrera E, Romberg N, Bar-Or A, Li R. JCI Insight. 2023 Apr 10;8(7):e155199. doi: 10.1172/jci.insight.155199.PMID: 36809296
Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex. Bhat P, Aksenova V, Gazzara M, Rex EA, Aslam S, Haddad C, Gao S, Esparza M, Cagatay T, Batten K, El Zahed SS, Arnaoutov A, Zhong H, Shay JW, Tolbert BS, Dasso M, Lynch KW, García-Sastre A, Fontoura BMA. Nat Commun. 2023 Apr 21;14(1):2304. doi: 10.1038/s41467-023-37911-0. PMID: 37085480
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes . Rubio-Navarro A, Gómez-Banoy N, Stoll L, Dündar F, Mawla AM, Ma L, Cortada E, Zumbo P, Li A, Reiterer M, Montoya-Oviedo N, Homan EA, Imai N, Gilani A, Liu C, Naji A, Yang B, Chong ACN, Cohen DE, Chen S, Cao J, Pitt GS, Huising MO, Betel D, Lo JC. Nat Cell Biol. 2023 Apr;25(4):565-578. doi: 10.1038/s41556-023-01103-1. Epub 2023 Mar 16. PMID: 36928765
Advances in cancer immunotherapies. Dagher OK, Schwab RD, Brookens SK, Posey AD Jr. Cell. 2023 Apr 13;186(8):1814-1814.e1. doi: 10.1016/j.cell.2023.02.039. PMID: 37059073
Tumor-derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors. Zhong W, Xiao Z, Qin Z, Yang J, Wen Y, Yu Z, Li Y, Sheppard NC, Fuchs SY, Xu X, Herlyn M, June CH, Pure E, Guo W. Cancer Res. 2023 Apr 28:CAN-22-2220. doi: 10.1158/0008-5472.CAN-22-2220. Online ahead of print. PMID: 37115855
Immunogenicity and protective efficacy of SARS-CoV-2 mRNA vaccine encoding secreted non-stabilized spike in female mice. Prompetchara E, Ketloy C, Alameh MG, Tharakhet K, Kaewpang P, Yostrerat N, Pitakpolrat P, Buranapraditkun S, Manopwisedjaroen S, Thitithanyanont A, Jongkaewwattana A, Hunsawong T, Im-Erbsin R, Reed M, Wijagkanalan W, Patarakul K, Techawiwattanaboon T, Palaga T, Lam K, Heyes J, Weissman D, Ruxrungtham K. Nat Commun. 2023 Apr 21;14(1):2309. doi: 10.1038/s41467-023-37795-0. PMID: 37085495
A viral biomolecular condensate coordinates assembly of progeny particles. Charman M, Grams N, Kumar N, Halko E, Dybas JM, Abbott A, Lum KK, Blumenthal D, Tsopurashvili E, Weitzman MD. Nature. 2023 Apr;616(7956):332-338. doi: 10.1038/s41586-023-05887-y. Epub 2023 Apr 5. PMID: 37020020

March

Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells. Mai D, Johnson O, Reff J, Fan TJ, Scholler J, Sheppard NC, June CH. Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2218632120. doi: 10.1073/pnas.2218632120. Epub 2023 Mar 15. PMID: 36920923
Multivariate indicators of disease severity in COVID-19. Bean J, Kuri-Cervantes L, Pennella M, Betts MR, Meyer NJ, Hassan WM. Sci Rep. 2023 Mar 29;13(1):5145. doi: 10.1038/s41598-023-31683-9. PMID: 36991002
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate. Shiraishi K, Shah PP, Morley MP, Loebel C, Santini GT, Katzen J, Basil MC, Lin SM, Planer JD, Cantu E, Jones DL, Nottingham AN, Li S, Cardenas-Diaz FL, Zhou S, Burdick JA, Jain R, Morrisey EE. Cell. 2023 Mar 30;186(7):1478-1492.e15. doi: 10.1016/j.cell.2023.02.010. Epub 2023 Mar 3. PMID: 36870331
Harnessing imaging tools to guide immunotherapy trials: summary from the National Cancer Institute Cancer Imaging Steering Committee workshop. Shankar LK, Schöder H, Sharon E, Wolchok J, Knopp MV, Wahl RL, Ellingson BM, Hall NC, Yaffe MJ, Towbin AJ, Farwell MD, Pryma D, Poussaint TY, Wright CL, Schwartz L, Harisinghani M, Mahmood U, Wu AM, Leung D, de Vries EGE, Tang Y, Beach G, Reeves SA. Lancet Oncol. 2023 Mar;24(3):e133-e143. doi: 10.1016/S1470-2045(22)00742-2. PMID: 36858729
HIV post-treatment controllers have distinct immunological and virological features. Etemad B, Sun X, Li Y, Melberg M, Moisi D, Gottlieb R, Ahmed H, Aga E, Bosch RJ, Acosta EP, Yuki Y, Martin MP, Carrington M, Gandhi RT, Jacobson JM, Volberding P, Connick E, Mitsuyasu R, Frank I, Saag M, Eron JJ, Skiest D, Margolis DM, Havlir D, Schooley RT, Lederman MM, Yu XG, Li JZ. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218960120. doi: 10.1073/pnas.2218960120. Epub 2023 Mar 6. PMID: 36877848
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation. Ko KI, DerGarabedian BP, Chen Z, Debnath R, Ko A, Link BN, Korostoff JM, Graves DT. J Exp Med. 2023 Mar 6;220(3):e20221350. doi: 10.1084/jem.20221350. Epub 2022 Dec 30. PMID: 36584405
Clinical Outcomes Associated With Pembrolizumab Monotherapy Among Adults With Diffuse Malignant Peritoneal Mesothelioma. Marmarelis ME, Wang X, Roshkovan L, Grady CB, Miura JT, Ginsberg MS, Ciunci CA, Egger J, Walker S, Cercek A, Foote MB, Litzky LA, Nash G, Haas AR, Karakousis GC, Cengel KA, Katz SI, Zauderer MG, Langer CJ, Offin M. JAMA Netw Open. 2023 Mar 1;6(3):e232526. doi: 10.1001/jamanetworkopen.2023.2526. PMID: 36897589
IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii. Clark JT, Weizman OE, Aldridge DL, Shallberg LA, Eberhard J, Lanzar Z, Wasche D, Huck JD, Zhou T, Ring AM, Hunter CA. Cell Rep. 2023 Mar 28;42(3):112147. doi: 10.1016/j.celrep.2023.112147. Epub 2023 Feb 23. PMID: 36827187
Immature natural killer cells promote progression of triple-negative breast cancer. Thacker G, Henry S, Nandi A, Debnath R, Singh S, Nayak A, Susnik B, Boone MM, Zhang Q, Kesmodel SB, Gumber S, Das GM, Kambayashi T, Dos Santos CO, Chakrabarti R. Sci Transl Med. 2023 Mar 8;15(686):eabl4414. doi: 10.1126/scitranslmed.abl4414. Epub 2023 Mar 8. PMID: 36888695
IL-33 is alarmin the uterus for labor. Kennedy EA, Jurado KA.Immunity. 2023 Mar 14;56(3):467-469. doi: 10.1016/j.immuni.2023.02.007.PMID: 36921571
Alternative splicing of HDAC7 regulates its interaction with 14-3-3 proteins to alter histone marks and target gene expression. Agosto LM, Mallory MJ, Ferretti MB, Blake D, Krick KS, Gazzara MR, Garcia BA, Lynch KW. Cell Rep. 2023 Mar 28;42(3):112273. doi: 10.1016/j.celrep.2023.112273. Epub 2023 Mar 17. PMID: 36933216
Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice. Ramos da Silva J, Bitencourt Rodrigues K, Formoso Pelegrin G, Silva Sales N, Muramatsu H, de Oliveira Silva M, Porchia BFMM, Moreno ACR, Aps LRMM, Venceslau-Carvalho AA, Tombácz I, Fotoran WL, Karikó K, Lin PJC, Tam YK, de Oliveira Diniz M, Pardi N, de Souza Ferreira LC. Sci Transl Med. 2023 Mar 8;15(686):eabn3464. doi: 10.1126/scitranslmed.abn3464. Epub 2023 Mar 8. PMID: 36867683
Molecular fate-mapping of serum antibody responses to repeat immunization . Schiepers A, van 't Wout MFL, Greaney AJ, Zang T, Muramatsu H, Lin PJC, Tam YK, Mesin L, Starr TN, Bieniasz PD, Pardi N, Bloom JD, Victora GD. Nature. 2023 Mar;615(7952):482-489. doi: 10.1038/s41586-023-05715-3. Epub 2023 Jan 16. PMID: 36646114
Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial. Rosenson RS, Gaudet D, Ballantyne CM, Baum SJ, Bergeron J, Kershaw EE, Moriarty PM, Rubba P, Whitcomb DC, Banerjee P, Gewitz A, Gonzaga-Jauregui C, McGinniss J, Ponda MP, Pordy R, Zhao J, Rader DJ. Nat Med. 2023 Mar;29(3):729-737. doi: 10.1038/s41591-023-02222-w. Epub 2023 Mar 6. PMID: 36879129
Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer . Patterson-Fortin J, Jadhav H, Pantelidou C, Phan T, Grochala C, Mehta AK, Guerriero JL, Wulf GM, Wolpin BM, Stanger BZ, Aguirre AJ, Cleary JM, D'Andrea AD, Shapiro GI. Nat Commun. 2023 Mar 13;14(1):1390. doi: 10.1038/s41467-023-37096-6. PMID: 36914658
Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation . Fan S, Spence JP, Feng Y, Hansen MEB, Terhorst J, Beltrame MH, Ranciaro A, Hirbo J, Beggs W, Thomas N, Nyambo T, Mpoloka SW, Mokone GG, Njamnshi A, Folkunang C, Meskel DW, Belay G, Song YS, Tishkoff SA. Cell. 2023 Mar 2;186(5):923-939.e14. doi: 10.1016/j.cell.2023.01.042. PMID: 36868214

February

Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4⁺ T cell reservoir. Wu VH, Nordin JML, Nguyen S, Joy J, Mampe F, Del Rio Estrada PM, Torres-Ruiz F, González-Navarro M, Luna-Villalobos YA, Ávila-Ríos S, Reyes-Terán G, Tebas P, Montaner LJ, Bar KJ, Vella LA, Betts MR. Nat Immunol. 2023 Feb;24(2):359-370. doi: 10.1038/s41590-022-01371-3. Epub 2022 Dec 19. PMID: 36536105
Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Yang F, Zhang D, Jiang H, Ye J, Zhang L, Bagley SJ, Winkler J, Gong Y, Fan Y. Sci Transl Med. 2023 Feb 15;15(683):eabq3558. doi: 10.1126/scitranslmed.abq3558. Epub 2023 Feb 15. PMID: 36791206
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Brewer RC, Lanz TV, Hale CR, Sepich-Poore GD, Martino C, Swafford AD, Carroll TS, Kongpachith S, Blum LK, Elliott SE, Blachere NE, Parveen S, Fak J, Yao V, Troyanskaya O, Frank MO, Bloom MS, Jahanbani S, Gomez AM, Iyer R, Ramadoss NS, Sharpe O, Chandrasekaran S, Kelmenson LB, Wang Q, Wong H, Torres HL, Wiesen M, Graves DT, Deane KD, Holers VM, Knight R, Darnell RB, Robinson WH, Orange DE. Sci Transl Med. 2023 Feb 22;15(684):eabq8476. doi: 10.1126/scitranslmed.abq8476. Epub 2023 Feb 22. PMID: 36812347
Malaria-driven adaptation of MHC class I in wild bonobo populations. Wroblewski EE, Guethlein LA, Anderson AG, Liu W, Li Y, Heisel SE, Connell AJ, Ndjango JN, Bertolani P, Hart JA, Hart TB, Sanz CM, Morgan DB, Peeters M, Sharp PM, Hahn BH, Parham P. Nat Commun. 2023 Feb 23;14(1):1033. doi: 10.1038/s41467-023-36623-9. PMID: 36823144
Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis. Xiao Y, Batmanov K, Hu W, Zhu K, Tom AY, Guan D, Jiang C, Cheng L, McCright SJ, Yang EC, Lanza MR, Liu Y, Hill DA, Lazar MA. Sci Transl Med. 2023 Feb 8;15(682):eadc9653. doi: 10.1126/scitranslmed.adc9653. Epub 2023 Feb 8. PMID: 36753562
Early T-bet promotes LFA1 upregulation required for CD8+ effector and memory T cell development. Pritchard GH, Phan AT, Christian DA, Blain TJ, Fang Q, Johnson J, Roy NH, Shallberg L, Kedl RM, Hunter CA. J Exp Med. 2023 Feb 6;220(2):e20191287. doi: 10.1084/jem.20191287. Epub 2022 Nov 29. PMID: 36445307
Preterm birth is associated with xenobiotics and predicted by the vaginal metabolome . Kindschuh WF, Baldini F, Liu MC, Liao J, Meydan Y, Lee HH, Heinken A, Thiele I, Thaiss CA, Levy M, Korem T. Nat Microbiol. 2023 Feb;8(2):246-259. doi: 10.1038/s41564-022-01293-8. Epub 2023 Jan 12.PMID: 36635575
Tissue adaptation and clonal segregation of human memory T cells in barrier sites. Poon MML, Caron DP, Wang Z, Wells SB, Chen D, Meng W, Szabo PA, Lam N, Kubota M, Matsumoto R, Rahman A, Luning Prak ET, Shen Y, Sims PA, Farber DL. Nat Immunol. 2023 Feb;24(2):309-319. doi: 10.1038/s41590-022-01395-9. Epub 2023 Jan 19. PMID: 36658238

January 2023

Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity. Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von Büdingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Or A. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2207291120. doi: 10.1073/pnas.2207291120. Epub 2023 Jan 12. PMID: 36634138
Improvement of Refractory Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease with Single-Agent Blockade of IL-1β and IL-18. Rood JE, Rezk A, Pogoriler J, Finn LS, Burnham JM, Josephson MB, Bar-Or A, Behrens EM, Canna SW. J Clin Immunol. 2023 Jan;43(1):101-108. doi: 10.1007/s10875-022-01353-y. Epub 2022 Aug 25. PMID: 36006569
Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction . Qiu J, Xu B, Ye D, Ren D, Wang S, Benci JL, Xu Y, Ishwaran H, Beltra JC, Wherry EJ, Shi J, Minn AJ. Nat Cancer. 2023 Jan;4(1):43-61. doi: 10.1038/s43018-022-00490-y. Epub 2023 Jan 16. PMID: 36646856
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies. Kennedy KM, de Goffau MC, Perez-Muñoz ME, Arrieta MC, Bäckhed F, Bork P, Braun T, Bushman FD, Dore J, de Vos WM, Earl AM, Eisen JA, Elovitz MA, Ganal-Vonarburg SC, Gänzle MG, Garrett WS, Hall LJ, Hornef MW, Huttenhower C, Konnikova L, Lebeer S, Macpherson AJ, Massey RC, McHardy AC, Koren O, Lawley TD, Ley RE, O'Mahony L, O'Toole PW, Pamer EG, Parkhill J, Raes J, Rattei T, Salonen A, Segal E, Segata N, Shanahan F, Sloboda DM, Smith GCS, Sokol H, Spector TD, Surette MG, Tannock GW, Walker AW, Yassour M, Walter J. Nature. 2023 Jan;613(7945):639-649. doi: 10.1038/s41586-022-05546-8. Epub 2023 Jan 25. PMID: 36697862
Role of Pfs47 in the dispersal of ancestral Plasmodium falciparum malaria through adaptation to different anopheline vectors.
Molina-Cruz A, Canepa GE, Dwivedi A, Liu W, Raytselis N, Antonio-Nkondjio C, Hahn BH, Silva JC, Barillas-Mury C. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2213626120. doi: 10.1073/pnas.2213626120. Epub 2023 Jan 23. PMID: 36689648
Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity. Laumaea A, Marchitto L, Ding S, Beaudoin-Bussières G, Prévost J, Gasser R, Chatterjee D, Gendron-Lepage G, Medjahed H, Chen HC, Smith AB 3rd, Ding H, Kappes JC, Hahn BH, Kirchhoff F, Richard J, Duerr R, Finzi A. Cell Rep. 2023 Jan 31;42(1):111983. doi: 10.1016/j.celrep.2022.111983. Epub 2023 Jan 10. PMID: 36640355
Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome. Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh AE, Nelson CA, Bryer JS, Ashchyan HA, Steele K, Forrestel A, Seykora JT, Micheletti RG, James WD, Rosenbach M, Leung TH. J Clin Invest. 2023 Jan 3;133(1):e162137. doi: 10.1172/JCI162137. PMID: 36355435
Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells. Oh S, Mao X, Manfredo-Vieira S, Lee J, Patel D, Choi EJ, Alvarado A, Cottman-Thomas E, Maseda D, Tsao PY, Ellebrecht CT, Khella SL, Richman DP, O'Connor KC, Herzberg U, Binder GK, Milone MC, Basu S, Payne AS. Nat Biotechnol. 2023 Jan 19. doi: 10.1038/s41587-022-01637-z. Online ahead of print. PMID: 36658341
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis . Han X, Gong N, Xue L, Billingsley MM, El-Mayta R, Shepherd SJ, Alameh MG, Weissman D, Mitchell MJ. Nat Commun. 2023 Jan 17;14(1):75. doi: 10.1038/s41467-022-35637-z. PMID: 36650129
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation. Castillero E, Fitzpatrick E, Keeney SJ, D'Angelo AM, Pressly BB, Simpson MT, Kurade M, Erwin WC, Moreno V, Camillo C, Shukla HJ, Inamdar VV, Aghali A, Grau JB, Salvati E, Nissim I, Rauova L, Oyama MA, Stachelek SJ, Brown C, Krieger AM, Levy RJ, Ferrari G. Sci Transl Med. 2023 Jan 4;15(677):eadc9606. doi: 10.1126/scitranslmed.adc9606. Epub 2023 Jan 4. PMID: 36599005
BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network . Sun X, Klingbeil O, Lu B, Wu C, Ballon C, Ouyang M, Wu XS, Jin Y, Hwangbo Y, Huang YH, Somerville TDD, Chang K, Park J, Chung T, Lyons SK, Shi J, Vogel H, Schulder M, Vakoc CR, Mills AA. Nature. 2023 Jan;613(7942):195-202. doi: 10.1038/s41586-022-05551-x. Epub 2022 Dec 21. PMID: 36544023
Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation. Michieletto MF, Tello-Cajiao JJ, Mowel WK, Chandra A, Yoon S, Joannas L, Clark ML, Jimenez MT, Wright JM, Lundgren P, Williams A, Thaiss CA, Vahedi G, Henao-Mejia J. Nat Immunol. 2023 Jan;24(1):42-54. doi: 10.1038/s41590-022-01295-y. Epub 2022 Sep 1. PMID: 36050414
A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers . Wang D, Quesnel-Vallieres M, Jewell S, Elzubeir M, Lynch K, Thomas-Tikhonenko A, Barash Y. Nat Commun. 2023 Jan 4;14(1):63. doi: 10.1038/s41467-022-35369-0. PMID: 36599821

2022

Dec 2022

Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections.Saini P, Adeniji OS, Abdel-Mohsen M. EBioMedicine. 2022 Dec;86:104354. doi: 10.1016/j.ebiom.2022.104354. Epub 2022 Nov 10. PMID: 36371982
Stereospecific antiseizure activity in mouse and rat epilepsy models by a pyridinium inhibitor of TNFα/NFκB signaling. Pollard BS, Wen Z, Jacobson KA, Pollard JR. Eur J Med Chem Rep. 2022 Dec;6:100065. doi: 10.1016/j.ejmcr.2022.100065. Epub 2022 Jun 8. PMID: 36003949
Chimeric antigen receptor T-cell therapy yields similar outcomes in patients with and without cytokine release syndrome. Bhaskar ST, Patel VG, Porter DL, Schuster SJ, Nastoupil LJ, Perales MA, Alarcon Tomas A, Bishop MR, McGuirk JP, Maziarz RT, Chen A, Bachanova V, Maakaron J, Riedell PA, Oluwole OO. Blood Adv. 2022 Dec 12:bloodadvances.2022008937. doi: 10.1182/bloodadvances.2022008937. Online ahead of print. PMID: 36508286
Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B, Greco B, Sharma P, Minutolo NG, Gray F, Bear AS, Baroja ML, Cummins C, Xu C, Sanvito F, Goldgewicht AL, Blanchard T, Rodriguez-Garcia A, Klichinsky M, Bonini C, June CH, Posey AD Jr, Linette GP, Carreno BM, Casucci M, Powell DJ Jr. Cancer Cell. 2022 Dec 12;40(12):1470-1487.e7. doi: 10.1016/j.ccell.2022.11.006.PMID: 36513049
Aedes aegypti Malpighian tubules are immunologically activated following systemic Toll activation. Sneed SD, Dwivedi SB, DiGate C, Denecke S, Povelones M. Parasit Vectors. 2022 Dec 15;15(1):469. doi: 10.1186/s13071-022-05567-2.PMID: 36522779
Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74. Lee IK, Noguera-Ortega E, Xiao Z, Todd L, Scholler J, Song D, Liousia M, Lohith K, Xu K, Edwards KJ, Farwell MD, June CH, Albelda SM, Puré E, Sellmyer MA. Clin Cancer Res. 2022 Dec 15;28(24):5330-5342. doi: 10.1158/1078-0432.CCR-22-1379. PMID: 35972732
Author Correction: Decade-long leukaemia remissions with persistence of CD4⁺CAR T cells . Melenhorst JJ, Chen GM, Wang M, Porter DL, Chen C, Collins MA, Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, Gill SI, Loren AW, Tian L, Kulikovskaya I, Gupta M, Ambrose DE, Davis MM, Fraietta JA, Brogdon JL, Young RM, Chew A, Levine BL, Siegel DL, Alanio C, Wherry EJ, Bushman FD, Lacey SF, Tan K, June CH. Nature. 2022 Dec;612(7941):E22. doi: 10.1038/s41586-022-05376-8. PMID: 36477542
Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B, Greco B, Sharma P, Minutolo NG, Gray F, Bear AS, Baroja ML, Cummins C, Xu C, Sanvito F, Goldgewicht AL, Blanchard T, Rodriguez-Garcia A, Klichinsky M, Bonini C, June CH, Posey AD Jr, Linette GP, Carreno BM, Casucci M, Powell DJ Jr. Cancer Cell. 2022 Dec 12;40(12):1470-1487.e7. doi: 10.1016/j.ccell.2022.11.006. PMID: 36513049

Nov 2022

Human galectin-9 promotes the expansion of HIV reservoirs in vivo in humanized mice. Yuan Z, Giron LB, Hart C, Gyampoh A, Koshy J, Hong KY, Niki T, Premeaux TA, Ndhlovu LC, Deleage C, Montaner LJ, Abdel-Mohsen M. AIDS 2022 Nov 28. Online ahead of print. PMID: 36460646
HIV-1 Vpu restricts Fc-mediated effector functions in vivo. Prévost J, Anand SP, Rajashekar JK, Zhu L, Richard J, Goyette G, Medjahed H, Gendron-Lepage G, Chen HC, Chen Y, Horwitz JA, Grunst MW, Zolla-Pazner S, Haynes BF, Burton DR, Flavell RA, Kirchhoff F, Hahn BH, Smith AB 3rd, Pazgier M, Nussenzweig MC, Kumar P, Finzi A. Cell Rep. 2022 Nov 8;41(6):111624. doi: 10.1016/j.celrep.2022.111624. PMID: 36351384
Evasion of cGAS and TRIM5 defines pandemic HIV. Zuliani-Alvarez L, Govasli ML, Rasaiyaah J, Monit C, Perry SO, Sumner RP, McAlpine-Scott S, Dickson C, Rifat Faysal KM, Hilditch L, Miles RJ, Bibollet-Ruche F, Hahn BH, Boecking T, Pinotsis N, James LC, Jacques DA, Towers GJ. Nat Microbiol. 2022 Nov;7(11):1762-1776. doi: 10.1038/s41564-022-01247-0. Epub 2022 Oct 26. PMID: 36289397
"Visualization" of pain using cerebral ¹⁸F-FDG PET/CT following surgical treatment of lumbar disc herniation. Støttrup CC, Mortensen CH, Piri R, Khosravi M, Newberg A, Andersen MØ, Alavi A, Grupe P, Høilund-Carlsen PF. Eur Spine J. 2022 Nov 13. doi: 10.1007/s00586-022-07442-1. Online ahead of print.PMID: 36371750
The Selective Estrogen Receptor Modulator, Raloxifene, Is Protective Against Renal Ischemia-reperfusion Injury.Hernandez P, O'Brien C, Concors SJ, Wang Z, Ge G, Hancock WW, Levine MH. Transplantation. 2022 Nov 1;106(11):2166-2171. doi: 10.1097/TP.0000000000004194. Epub 2022 Oct 21. PMID: 35655356
Pre-clinical investigation of astatine-211-parthanatine for high-risk neuroblastoma. Makvandi M, Samanta M, Martorano P, Lee H, Gitto SB, Patel K, Groff D, Pogoriler J, Martinez D, Riad A, Dabagian H, Zaleski M, Taghvaee T, Xu K, Lee JY, Hou C, Farrel A, Batra V, Carlin SD, Powell DJ Jr, Mach RH, Pryma DA, Maris JM. Commun Biol. 2022 Nov 17;5(1):1260. doi: 10.1038/s42003-022-04209-8. PMID: 36396952
Divergent clonal differentiation trajectories of T cell exhaustion. Daniel B, Yost KE, Hsiung S, Sandor K, Xia Y, Qi Y, Hiam-Galvez KJ, Black M, J Raposo C, Shi Q, Meier SL, Belk JA, Giles JR, Wherry EJ, Chang HY, Egawa T, Satpathy AT. Nat Immunol. 2022 Nov;23(11):1614-1627. doi: 10.1038/s41590-022-01337-5. Epub 2022 Oct 26. PMID: 36289450
CAR T therapy extends its reach to autoimmune diseases. Baker DJ, June CH. Cell. 2022 Nov 23;185(24):4471-4473. doi: 10.1016/j.cell.2022.10.026. PMID: 36423579
CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease. Pierson SK, Katz L, Williams R, Mumau M, Gonzalez M, Guzman S, Rubenstein A, Oromendia AB, Beineke P, Fosså A, van Rhee F, Fajgenbaum DC .Nat Commun. 2022 Nov 24;13(1):7236. doi: 10.1038/s41467-022-34873-7. PMID: 36433996
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes. Arevalo CP, Bolton MJ, Le Sage V, Ye N, Furey C, Muramatsu H, Alameh MG, Pardi N, Drapeau EM, Parkhouse K, Garretson T, Morris JS, Moncla LH, Tam YK, Fan SHY, Lakdawala SS, Weissman D, Hensley SE. Science. 2022 Nov 25;378(6622):899-904. doi: 10.1126/science.abm0271. Epub 2022 Nov 24. PMID: 36423275
Comparison of Maternal and Neonatal Antibody Levels After COVID-19 Vaccination vs SARS-CoV-2 Infection. Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Briker SM, Triebwasser JE, Gerber JS, Morris JS, Weirick ME, McAllister CM, Hensley SE, Puopolo KM. JAMA Netw Open. 2022 Nov 1;5(11):e2240993. doi: 10.1001/jamanetworkopen.2022.40993. PMID: 36350652

Oct 2022

A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two doses. Tauzin A, Gong SY, Chatterjee D, Ding S, Painter MM, Goel RR, Beaudoin-Bussières G, Marchitto L, Boutin M, Laumaea A, Okeny J, Gendron-Lepage G, Bourassa C, Medjahed H, Goyette G, Williams JC, Bo Y, Gokool L, Morrisseau C, Arlotto P, Bazin R, Fafard J, Tremblay C, Kaufmann DE, De Serres G, Richard J, Côté M, Duerr R, Martel-Laferrière V, Greenplate AR, Wherry EJ, Finzi A. Cell Rep. 2022 Oct 5:111554. doi: 10.1016/j.celrep.2022.111554. Online ahead of print. PMID: 36244343
SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations. Anderson EM, Li SH, Awofolaju M, Eilola T, Goodwin E, Bolton MJ, Gouma S, Manzoni TB, Hicks P, Goel RR, Painter MM, Apostolidis SA, Mathew D, Dunbar D, Fiore D, Brock A, Weaver J, Millar JS, DerOhannessian S; UPenn COVID Processing Unit, Greenplate AR, Frank I, Rader DJ, Wherry EJ, Bates P, Hensley SE. Cell Rep. 2022 Oct 18;41(3):111496. doi: 10.1016/j.celrep.2022.111496. PMID: 36261003
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics. Giles JR, Ngiow SF, Manne S, Baxter AE, Khan O, Wang P, Staupe R, Abdel-Hakeem MS, Huang H, Mathew D, Painter MM, Wu JE, Huang YJ, Goel RR, Yan PK, Karakousis GC, Xu X, Mitchell TC, Huang AC, Wherry EJ. Nat Immunol. 2022 Oct 21. doi: 10.1038/s41590-022-01338-4. Online ahead of print. PMID: 36271148
PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma. Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA, Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. JCI Insight. 2022 Oct 24;7(20):e165688. doi: 10.1172/jci.insight.165688. PMID: 36278493
Assessing Coronary Artery and Aortic Calcification in Patients with Prostate Cancer Using 18F-Sodium Fluoride PET/Computed Tomography. Raynor WY, Borja AJ, Zhang V, Kothekar E, Lau HC, Ng SJ, Seraj SM, Rojulpote C, Taghvaei R, Jin KY, Werner TJ, Høilund-Carlsen PF, Alavi A, Revheim ME. PET Clin. 2022 Oct;17(4):653-659. doi: 10.1016/j.cpet.2022.07.009. PMID: 36229106
Feasibility of Global Assessment of Bone Metastases in Prostate Cancer with 18F-Sodium Fluoride-PET/Computed Tomography. Koa B, Raynor WY, Park PSU, Borja AJ, Singhal S, Kuang A, Zhang V, Werner TJ, Alavi A, Revheim ME. PET Clin.2022 Oct;17(4):631-640. doi: 10.1016/j.cpet.2022.07.007. PMID: 36229105
Methadone use is associated with increased levels of sCD14, immune activation, and inflammation during suppressed HIV infection. Azzoni L, Giron LB, Vadrevu S, Zhao L, Lalley-Chareczko L, Hiserodt E, Fair M, Lynn K, Trooskin S, Mounzer K, Abdel-Mohsen M, Montaner LJ. J Leukoc Biol. 2022 Oct;112(4):733-744. doi: 10.1002/JLB.4A1221-678RR. Epub 2022 Aug 2. PMID: 35916053
Whole-Brain Perfusion via Right Common Carotid Artery With Type 2 Proatlantal Intersegmental Artery. Zuflacht JP, Liang C, Burkhardt JK, Favilla CG. Stroke. 2022 Aug 12:101161STROKEAHA122040239. doi: 10.1161/STROKEAHA.122.040239. Online ahead of print. PMID: 35959680
National Survey on Flow-Diverting Stents for Intracranial Aneurysms in the United States. Salem MM, Elfil M, Aboutaleb PE, Dmytriw AA, Thomas AJ, Hassan AE, Mascitelli JR, Kan P, Jankowitz BT, Burkhardt JK. World Neurosurg. 2022 Oct;166:e958-e967. doi: 10.1016/j.wneu.2022.07.144. Epub 2022 Aug 8. PMID: 35953041
Alterations in the respiratory tract microbiome in COVID-19: current observations and potential significance. Merenstein C, Bushman FD, Collman RG. Microbiome. 2022 Oct 5;10(1):165. doi: 10.1186/s40168-022-01342-8. PMID: 36195943
Author Correction: Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott-Aldrich syndrome. Magnani A, Semeraro M, Adam F, Booth C, Dupré L, Morris EC, Gabrion A, Roudaut C, Borgel D, Toubert A, Clave E, Abdo C, Gorochov G, Petermann R, Guiot M, Miyara M, Moshous D, Magrin E, Denis A, Suarez F, Lagresle C, Roche AM, Everett J, Trinquand A, Guisset M, Bayford JX, Hacein-Bey-Abina S, Kauskot A, Elfeky R, Rivat C, Abbas S, Gaspar HB, Macintyre E, Picard C, Bushman FD, Galy A, Fischer A, Six E, Thrasher AJ, Cavazzana M. Nat Med. 2022 Oct;28(10):2217. doi: 10.1038/s41591-022-01985-y. PMID: 35945284
Protection of regulatory T cells from fragility and inactivation in the tumor microenvironment. Zhang H, Tomar VS, Li J, Basavaraja R, Yan F, Gui J, McBrearty N, Costich TL, Beiting DP, Blanco MA, Nefedova Y, Conejo-Garcia JR, Saggu G, Berger AJ, Gabrilovich DI, Fuchs SY. Cancer Immunol Res. 2022 Oct 18:CIR-22-0295. doi: 10.1158/2326-6066.CIR-22-0295. Online ahead of print. PMID: 36255418
The lncRNA ALPHA specifically targets chikungunya virus to control infection. Basavappa MG, Ferretti M, Dittmar M, Stoute J, Sullivan MC, Whig K, Shen H, Liu KF, Schultz DC, Beiting DP, Lynch KW, Henao-Mejia J, Cherry S. Mol Cell. 2022 Oct 6;82(19):3729-3744.e10. doi: 10.1016/j.molcel.2022.08.030. Epub 2022 Sep 26. PMID: 36167073
Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling. Crnkovic S, Valzano F, Fließer E, Gindlhuber J, Thekkekara Puthenparampil H, Basil M, Morley MP, Katzen J, Gschwandtner E, Klepetko W, Cantu E, Wolinski H, Olschewski H, Lindenmann J, Zhao YY, Morrisey EE, Marsh LM, Kwapiszewska G. JCI Insight. 2022 Oct 24;7(20):e153471. doi: 10.1172/jci.insight.153471. PMID: 36099047
Epidemiology, risk factors, and outcomes of lung retransplantation: An analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry. Harhay MO, Cherikh WS, Toll AE, Christie JD, Stehlik J, Chambers D, Hayes D Jr, Cantu E. J Heart Lung Transplant. 2022 Oct;41(10):1478-1486. doi: 10.1016/j.healun.2022.06.022. Epub 2022 Jul 5. PMID: 35933297
TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model. Maio N, Cherry S, Schultz DC, Hurst BL, Linehan WM, Rouault TA. iScience. 2022 Oct 21;25(10):105074. doi: 10.1016/j.isci.2022.105074. Epub 2022 Sep 6. PMID: 36093377
Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer. Lee YG, Guruprasad P, Ghilardi G, Pajarillo R, Sauter CT, Patel R, Ballard HJ, Hong SJ, Chun I, Yang N, Amelsberg KV, Cummins KD, Svoboda J, Gill S, Chong EA, North K, Church SE, Fraietta JA, Chang WJ, Lacey SF, Lu XM, Zhang Y, Whig K, Schultz DC, Cherry S, Gerson J, Schuster SJ, Porazzi P, Ruella M. Cancer Discov. 2022 Oct 5;12(10):2372-2391. doi: 10.1158/2159-8290.CD-21-1026. PMID: 35904479
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation.Uriarte SM, Hajishengallis G. Immunol Rev. 2022 Oct 22. doi: 10.1111/imr.13152. Online ahead of print. PMID: 36271881
The role of neutrophils in trained immunity. Kalafati L, Hatzioannou A, Hajishengallis G, Chavakis T. Immunol Rev. 2022 Oct 3. doi: 10.1111/imr.13142. Online ahead of print. PMID: 36190144
Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis. Wang H, Ideguchi H, Kajikawa T, Mastellos DC, Lambris JD, Hajishengallis G. J Immunol. 2022 Oct 1;209(7):1370-1378. doi: 10.4049/jimmunol.2200338. Epub 2022 Aug 26. PMID: 36028293
Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer. Nandi A, Debnath R, Nayak A, To TKJ, Thacker G, Reilly M, Gumber S, Karagounis I, Li N, Lengner CJ, Haldar M, Welm AL, Blanco AM, Thomas C, Chakrabarti R. Cancer Res. 2022 Oct 17;82(20):3718-3733. doi: 10.1158/0008-5472.CAN-21-1225.PMID: 36007109
Multiple health-related behaviours among Fly-In Fly-Out workers in the mining industry in Australia: A cross-sectional survey during the COVID-19 pandemic. Asare BY, Thomas E, Affandi JS, Schammer M, Harris C, Kwasnicka D, Powell D, Reid CM, Robinson S. PLoS One. 2022 Oct 27;17(10):e0275008. doi: 10.1371/journal.pone.0275008. eCollection 2022.PMID: 36301801
GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2. Thapaliya M, Amponnawarat A, Tesmer JJG, Ali H. Front Immunol. 2022 Oct 6;13:1032497. doi: 10.3389/fimmu.2022.1032497. eCollection 2022.PMID: 36275707
COVID-19 and children. Pierce CA, Herold KC, Herold BC, Chou J, Randolph A, Kane B, McFarland S, Gurdasani D, Pagel C, Hotez P, Cobey S, Hensley SE. Science. 2022 Sep 9;377(6611):1144-1149. doi: 10.1126/science.ade1675. Epub 2022 Sep 8. PMID: 36074833

Sept 2022

Building effective collaborations for the study of COVID-19 across the severity spectrum. Agyekum RS, Abramoff BA, Wherry EJ, Meyer NJ. Nat Immunol. 2022 Sep;23(9):1287-1290. doi: 10.1038/s41590-022-01283-2. PMID: 35999396
Atherosclerosis Burdens in Diabetes Mellitus: Assessment by PET Imaging. Høilund-Carlsen PF, Piri R, Madsen PL, Revheim ME, Werner TJ, Alavi A, Gerke O, Sturek M. Int J Mol Sci. 2022 Sep 6;23(18):10268. doi: 10.3390/ijms231810268. PMID: 36142181
Association of Apremilast With Vascular Inflammation and Cardiometabolic Function in Patients With Psoriasis: The VIP-A Phase 4, Open-label, Nonrandomized Clinical Trial. Gelfand JM, Shin DB, Armstrong AW, Tyring SK, Blauvelt A, Gottlieb S, Lockshin BN, Kalb RE, Fitzsimmons R, Rodante J, Parel P, Manyak GA, Mendelsohn L, Noe MH, Papadopoulos M, Syed MN, Werner TJ, Wan J, Playford MP, Alavi A, Mehta NN. JAMA Dermatol. 2022 Sep 21:e223862. doi: 10.1001/jamadermatol.2022.3862. Online ahead of print. PMID: 36129688
Monitoring the Progression of a Calcifying Uterine Leiomyoma: Detection Using 18F-NaF-PET/CT. Resto DA, Park PSU, Werner TJ, Høilund-Carlsen PF, Alavi A. Clin Nucl Med. 2022 Sep 21. doi: 10.1097/RLU.0000000000004395. Online ahead of print. PMID: 36127774
Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling. Giron LB, Peluso MJ, Ding J, Kenny G, Zilberstein NF, Koshy J, Hong KY, Rasmussen H, Miller GE, Bishehsari F, Balk RA, Moy JN, Hoh R, Lu S, Goldman AR, Tang HY, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Kelly JD, Wasse H, Martin JN, Liu Q, Keshavarzian A, Landay A, Deeks SG, Henrich TJ, Abdel-Mohsen M. JCI Insight. 2022 Sep 22;7(18):e164813. doi: 10.1172/jci.insight.164813.
PMID: 36134654
The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer. Mirji G, Worth A, Bhat SA, El Sayed M, Kannan T, Goldman AR, Tang HY, Liu Q, Auslander N, Dang CV, Abdel-Mohsen M, Kossenkov A, Stanger BZ, Shinde RS. Sci Immunol. 2022 Sep 9;7(75):eabn0704. doi: 10.1126/sciimmunol.abn0704. Epub 2022 Sep 9. PMID: 36083892
The Lung Allograft Microbiome Associates with Pepsin, Inflammation, and Primary Graft Dysfunction. McGinniss JE, Whiteside SA, Deek RA, Simon-Soro A, Graham-Wooten J, Oyster M, Brown MD, Cantu E, Diamond JM, Li H, Christie JD, Bushman FD, Collman RG. Am J Respir Crit Care Med. 2022 Sep 14. doi: 10.1164/rccm.202112-2786OC. Online ahead of print. PMID: 36103583
Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission. Daniell H, Nair SK, Guan H, Guo Y, Kulchar RJ, Torres MDT, Shahed-Al-Mahmud M, Wakade G, Liu YM, Marques AD, Graham-Wooten J, Zhou W, Wang P, Molugu SK, de Araujo WR, de la Fuente-Nunez C, Ma C, Short WR, Tebas P, Margulies KB, Bushman FD, Mante FK, Ricciardi RP, Collman RG, Wolff MS. Biomaterials. 2022 Sep;288:121671. doi: 10.1016/j.biomaterials.2022.121671. Epub 2022 Jul 18. PMID: 35953331
Altered adipose tissue macrophage populations in people with HIV on integrase inhibitor-containing antiretroviral therapy. Vakili S, Paneru B, Guerrier CM, Miller J, Baumrin E, Forrestel A, Lynn K, Frank I, Lo Re V 3rd, Collman RG, Hill DA. AIDS. 2022 Sep 1;36(11):1493-1500. doi: 10.1097/QAD.0000000000003278. Epub 2022 Jul 8. PMID: 35848549
ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes. Lu Z, McBrearty N, Chen J, Tomar VS, Zhang H, De Rosa G, Tan A, Weljie AM, Beiting DP, Miao Z, George SS, Berger A, Saggu G, Diehl JA, Koumenis C, Fuchs SY. Cell Metab. 2022 Sep 6;34(9):1342-1358.e7. doi: 10.1016/j.cmet.2022.08.007. PMID: 36070682
Defining and targeting patterns of T cell dysfunction in inborn errors of immunity. Campos JS, Henrickson SE. Front Immunol. 2022 Sep 14;13:932715. doi: 10.3389/fimmu.2022.932715. eCollection 2022. PMID: 36189259

August 2022

The effects of limb laterality and age on the inflammation and bone turnover of the acromioclavicular shoulder joint: 18 F-fluorodeoxyglucose and 18 F-sodium-fluoride-PET/computed tomography study. Park PSU, McDonald E, Singh SB, Raynor WY, Werner TJ, Høilund-Carlsen PF, Alavi A. Nucl Med Commun. 2022 Aug 1;43(8):922-927. doi: 10.1097/MNM.0000000000001588. Epub 2022 May 30. PMID: 35634806
The Pennsylvania Postmarket Multicenter Experience With Flow Redirection Endoluminal Device. Salem MM, Kvint S, Hendrix P, Al Saiegh F, Gajjar AA, Choudhri O, Jankowitz BT, Goren O, Gross BA, Jabbour P, Lang M, Schirmer CM, Tjoumakaris SI, Griessenauer CJ, Burkhardt JK. Neurosurgery. 2022 Aug 1;91(2):280-285. doi: 10.1227/neu.0000000000001970. Epub 2022 Apr 12. PMID: 35394453
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Huang P, Peslak SA, Ren R, Khandros E, Qin K, Keller CA, Giardine B, Bell HW, Lan X, Sharma M, Horton JR, Abdulmalik O, Chou ST, Shi J, Crossley M, Hardison RC, Cheng X, Blobel GA. Nat Genet. 2022 Aug 8. doi: 10.1038/s41588-022-01152-6. Online ahead of print. PMID: 35941187
Targeting the EIF2AK1 signaling pathway rescues red blood cell production in SF3B1-mutant myelodysplastic syndromes with ringed sideroblasts. Adema V, Ma F, Kanagal-Shamanna R, Thongon N, Montalban-Bravo G, Yang H, Peslak SA, Wang F, Acha P, Sole F, Lockyer P, Cassari M, Maciejewski JP, Visconte V, Ganan-Gomez I, Song Y, Bueso-Ramos C, Pellegrini M, Tan TM, Bejar R, Carew JS, Halene S, Santini V, Al-Atrash G, Clise-Dwyer K, Garcia-Manero G, Blobel GA, Colla S. Blood Cancer Discov. 2022 Aug 4:BCD-21-0220. doi: 10.1158/2643-3230.BCD-21-0220. Online ahead of print. PMID: 35926182
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease? Cancro MP.Cell Metab. 2022 Aug 2;34(8):1081-1082. doi: 10.1016/j.cmet.2022.07.008.PMID: 35921814
Platelets get particular . Rauova L, Cines DB. Blood. 2022 Aug 4;140(5):413-414. doi: 10.1182/blood.2022016773. PMID: 35925641
Renally Excretable Silver Telluride Nanoparticles as Contrast Agents for X-ray Imaging . Nieves LM, Dong YC, Rosario-Berríos DN, Mossburg K, Hsu JC, Cramer GM, Busch TM, Maidment ADA, Cormode DP. ACS Appl Mater Interfaces. 2022 Aug 3;14(30):34354-34364. doi: 10.1021/acsami.2c06190. Epub 2022 Jul 22. PMID: 35867906
Gardnerella vaginalis alters cervicovaginal epithelial cell function through microbe-specific immune responses. Anton L, Ferguson B, Friedman ES, Gerson KD, Brown AG, Elovitz MA. Microbiome. 2022 Aug 4;10(1):119. doi: 10.1186/s40168-022-01317-9. PMID: 35922830
Gardnerella vaginalis induces matrix metalloproteinases in the cervicovaginal epithelium through TLR-2 activation . Gerson KD, Anton L, Ferguson B, Ravel J, Burris HH, Elovitz MA. J Reprod Immunol. 2022 Aug;152:103648. doi: 10.1016/j.jri.2022.103648. Epub 2022 May 23 .PMID: 35679790
Oncolytic Myxoma virus infects and damages the tegument of the human parasitic flatworm Schistosoma mansoni. Rahman MM, McFadden G, Ruthel G, Herbert DR, Freedman BD, Greenberg RM, Bais S. Exp Parasitol. 2022 Aug;239:108263. doi: 10.1016/j.exppara.2022.108263. Epub 2022 May 19. PMID: 35598646
Diagnostic Yield of Cone-beam-Derived Augmented Fluoroscopy and Ultrathin Bronchoscopy Versus Conventional Navigational Bronchoscopy Techniques. DiBardino DM, Kim RY, Cao Y, Andronov M, Lanfranco AR, Haas AR, Vachani A, Ma KC, Hutchinson CT. J Bronchology Interv Pulmonol. 2022 Aug 3. doi: 10.1097/LBR.0000000000000883. Online ahead of print. PMID: 35920067
The role of sex in exhaustion. Henrickson SE. Sci Immunol. 2022 Aug 5;7(74):eade1495. doi: 10.1126/sciimmunol.ade1495. Epub 2022 Aug 5. PMID: 35930655
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine . Herati RS, Knorr DA, Vella LA, Silva LV, Chilukuri L, Apostolidis SA, Huang AC, Muselman A, Manne S, Kuthuru O, Staupe RP, Adamski SA, Kannan S, Kurupati RK, Ertl HCJ, Wong JL, Bournazos S, McGettigan S, Schuchter LM, Kotecha RR, Funt SA, Voss MH, Motzer RJ, Lee CH, Bajorin DF, Mitchell TC, Ravetch JV, Wherry EJ. Nat Immunol. 2022 Aug;23(8):1183-1192. doi: 10.1038/s41590-022-01274-3. Epub 2022 Jul 28. PMID: 35902637
Multicenter assessment of augmented reality registration methods for image-guided interventions. Li N, Wakim J, Koethe Y, Huber T, Schenning R, Gade TP, Hunt SJ, Park BJ. Radiol Med. 2022 Aug;127(8):857-865. doi: 10.1007/s11547-022-01515-3. Epub 2022 Jun 23. PMID: 35737194
Preintervention Computed Tomography Improves the Performance of Endovascular Intervention in Patients with Abdominopelvic Trauma. McGraw JR, Cannon JW, Nadolski GJ, Hunt SJ, Clark TWI, Gade TPF. J Vasc Interv Radiol. 2022 Aug;33(8):979-986. doi: 10.1016/j.jvir.2022.05.006. Epub 2022 May 19. PMID: 35598852
High-Pressure Synthesis and Physical Properties of a Spinel Compound FeAl₂S₄. Duan L, Wang X, Zhao J, Zhang J, Du S, Feng Y, Zhao Z, Wang S, Jin C. Inorg Chem. 2022 Aug 9. doi: 10.1021/acs.inorgchem.2c02034. Online ahead of print. PMID: 35943140
T cell immunity to COVID-19 vaccines. Wherry EJ, Barouch DH. Science. 2022 Aug 19;377(6608):821-822. doi: 10.1126/science.add2897. Epub 2022 Aug 18. PMID: 35981045
Correction for Merenstein et al., "Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome". Merenstein C, Liang G, Whiteside SA, Cobián-Güemes AG, Merlino MS, Taylor LJ, Glascock A, Bittinger K, Tanes C, Graham-Wooten J, Khatib LA, Fitzgerald AS, Reddy S, Baxter AE, Giles JR, Oldridge DA, Meyer NJ, Wherry EJ, McGinniss JE, Bushman FD, Collman RG. mBio. 2022 Aug 31:e0229322. doi: 10.1128/mbio.02293-22. Online ahead of print. PMID: 36043873
Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling. Giron LB, Peluso MJ, Ding J, Kenny G, Zilberstein NF, Koshy J, Hong KY, Rasmussen H, Miller GE, Bishehsari F, Balk RA, Moy JN, Hoh R, Lu S, Goldman AR, Tang HY, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Kelly JD, Wasse H, Martin JN, Liu Q, Keshavarzian A, Landay A, Deeks SG, Henrich TJ, Abdel-Mohsen M. JCI Insight. 2022 Aug 8;7(15):e160989. doi: 10.1172/jci.insight.160989.
PMID: 35727635
COManeci MechANical dilation for vasospasm (COMMAND): multicenter experience. Salem MM, Khalife J, Desai S, Sharashidze V, Badger C, Kuhn AL, Monteiro A, Salahuddin H, Siddiqui AH, Singh J, Levy EI, Lang M, Grandhi R, Thomas AJ, Lin LM, Tanweer O, Burkhardt JK, Puri AS, Gross BA, Nossek E, Hassan AE, Shaikh HA, Jankowitz BT. J Neurointerv Surg.2022 Aug 24:jnis-2022-019272. doi: 10.1136/jnis-2022-019272. Online ahead of print. PMID: 36002289
Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11. Harberts EM, Grubaugh D, Akuma DC, Shin S, Ernst RK, Brodsky IE. Infect Immun. 2022 Aug 18;90(8):e0020122. doi: 10.1128/iai.00201-22. Epub 2022 Jul 14. PMID: 35862717
Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation. Alexander-Floyd J, Bass AR, Harberts EM, Grubaugh D, Buxbaum JD, Brodsky IE, Ernst RK, Shin S. Infect Immun. 2022 Aug 18;90(8):e0020822. doi: 10.1128/iai.00208-22. Epub 2022 Jul 14. PMID: 35862709
Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in Pennsylvania. Marques AD, Sherrill-Mix S, Everett JK, Adhikari H, Reddy S, Ellis JC, Zeliff H, Greening SS, Cannuscio CC, Strelau KM, Collman RG, Kelly BJ, Rodino KG, Bushman FD, Gagne RB, Anis E. mBio. 2022 Aug 24:e0210122. doi: 10.1128/mbio.02101-22. Online ahead of print. PMID: 36000731
The enigmatic roles of Anelloviridae and Redondoviridae in humans. Taylor LJ, Keeler EL, Bushman FD, Collman RG. Curr Opin Virol. 2022 Aug;55:101248. doi: 10.1016/j.coviro.2022.101248. Epub 2022 Jul 20. PMID: 35870315
Evaluating the state of the science for adeno-associated virus integration: An integrated perspective. Sabatino DE, Bushman FD, Chandler RJ, Crystal RG, Davidson BL, Dolmetsch R, Eggan KC, Gao G, Gil-Farina I, Kay MA, McCarty DM, Montini E, Ndu A, Yuan J; American Society of Gene and Cell Therapy (ASGCT) Working Group on AAV Integration. Mol Ther. 2022 Aug 3;30(8):2646-2663. doi: 10.1016/j.ymthe.2022.06.004. Epub 2022 Jun 10. PMID: 35690906
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease? Cancro MP. Cell Metab. 2022 Aug 2;34(8):1081-1082. doi: 10.1016/j.cmet.2022.07.008. PMID: 35921814
Contemporary trends in PGD incidence, outcomes, and therapies. Cantu E, Diamond JM, Cevasco M, Suzuki Y, Crespo M, Clausen E, Dallara L, Ramon CV, Harmon MT, Bermudez C, Benvenuto L, Anderson M, Wille KM, Weinacker A, Dhillon GS, Orens J, Shah P, Merlo C, Lama V, McDyer J, Snyder L, Palmer S, Hartwig M, Hage CA, Singer J, Calfee C, Kukreja J, Greenland JR, Ware LB, Localio R, Hsu J, Gallop R, Christie JD. J Heart Lung Transplant. 2022 Aug 31:S1053-2498(22)02080-0. doi: 10.1016/j.healun.2022.08.013. Online ahead of print. PMID: 36216694
Clinical impact of a modified lung allocation score that mitigates selection bias. Schnellinger EM, Cantu E, Schaubel DE, Kimmel SE, Stephens-Shields AJ. J Heart Lung Transplant. 2022 Aug 7:S1053-2498(22)02068-X. doi: 10.1016/j.healun.2022.08.003. Online ahead of print. PMID: 36064649
A Conceptual Model for Sources of Differential Selection in Lung Transplant Allocation. Schnellinger EM, Cantu E,Kimmel SE, Szymczak JE. Ann Am Thorac Soc. 2022 Aug 31. doi: 10.1513/AnnalsATS.202202-105OC. Online ahead of print. PMID: 36044711
Changes in Circulating Tumor DNA Reflect Clinical Benefit Across Multiple Studies of Patients With Non-Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors. Vega DM, Nishimura KK, Zariffa N, Thompson JC, Hoering A, Cilento V, Rosenthal A, Anagnostou V, Baden J, Beaver JA, Chaudhuri AA, Chudova D, Fine AD, Fiore J, Hodge R, Hodgson D, Hunkapiller N, Klass DM, Kobie J, Peña C, Pennello G, Peterman N, Philip R, Quinn KJ, Raben D, Rosner GL, Sausen M, Tezcan A, Xia Q, Yi J, Young AG, Stewart MD, Carpenter EL, Aggarwal C, Allen J. JCO Precis Oncol. 2022 Aug;6:e2100372. doi: 10.1200/PO.21.00372. PMID: 35952319
Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. Okuda K, Silva Costa Franco MM, Yasunaga A, Gazzinelli R, Rabinovitch M, Cherry S, Silverman N. iScience. 2022 Aug 13;25(9):104909. doi: 10.1016/j.isci.2022.104909. eCollection 2022 Sep 16. PMID: 36060064
The role of sex in exhaustion. Henrickson SE. Sci Immunol. 2022 Aug 5;7(74):eade1495. doi: 10.1126/sciimmunol.ade1495. Epub 2022 Aug 5. PMID: 35930655

July 2022

Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV. Ma T, McGregor M, Giron L, Xie G, George AF, Abdel-Mohsen M, Roan NR.Elife. 2022 Jul 5;11:e78870. doi: 10.7554/eLife.78870. PMID: 35787792
Volumetric parameters from [¹⁸ F]FDG PET/CT predicts survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms. Langen Stokmo H, Aly M, Bowitz Lothe IM, Borja AJ, Mehdizadeh Seraj S, Ghorpade R, Miao X, Hjortland GO, Malinen E, Sorbye H, Werner TJ, Alavi A, Revheim ME. J Neuroendocrinol. 2022 Jul;34(7):e13170. doi: 10.1111/jne.13170. Epub 2022 Jun 21. PMID: 35729738
Fluorodeoxyglucose versus Non-Fluorodeoxyglucose PET-Computed Tomography in Less-Explored Domains: An Appraisal. Basu S, Kumar R, Alavi A. PET Clin. 2022 Jul;17(3):xv-xvi. doi: 10.1016/j.cpet.2022.05.001. PMID: 35717107
Fluorodeoxyglucose PET/Computed Tomography in Evaluation of Prosthetic Joints and Diabetic Foot: A Comparative Perspective with Other Functional Imaging Modalities. Rachh SS, Basu S, Alavi A. PET Clin. 2022 Jul;17(3):517-531. doi: 10.1016/j.cpet.2022.02.002. PMID: 35717105
Positron Emission Tomography-Based Assessment of Cognitive Impairment and Dementias, Critical Role of Fluorodeoxyglucose in such Settings. Newberg AB, Coble R, Khosravi M, Alavi A. PET Clin. 2022 Jul;17(3):479-494. doi: 10.1016/j.cpet.2022.03.009. PMID: 35717103
18F-FDG Versus Non-FDG PET Tracers in Multiple Myeloma. Hemrom A, Tupalli A, Alavi A, Kumar R. PET Clin. 2022 Jul;17(3):415-430. doi: 10.1016/j.cpet.2022.03.001. PMID: 35717100
Molecular Imaging Assessment of Hormonally Sensitive Breast Cancer: An Appraisal of 2-[18F]-Fluoro-2-Deoxy-Glucose and Newer Non-2-[18F]-Fluoro-2-Deoxy-Glucose PET Tracers. Yadav D, Kumar R, Phulia A, Basu S, Alavi A. PET Clin. 2022 Jul;17(3):399-413. doi: 10.1016/j.cpet.2022.04.001. PMID: 35717099
Facts and Fictions About [18F]FDG versus Other Tracers in Managing Patients with Brain Tumors: It Is Time to Rectify the Ongoing Misconceptions. Withofs N, Kumar R, Alavi A, Hustinx R. PET Clin. 2022 Jul;17(3):327-342. doi: 10.1016/j.cpet.2022.03.004. PMID: 35717096
Role of Fluorodeoxyglucose-PET in Interventional Radiology. Zandifar A, Saucedo J, Vossough A, Alavi A, Hunt SJ. PET Clin. 2022 Jul;17(3):543-553. doi: 10.1016/j.cpet.2022.03.003. Epub 2022 May 31. PMID: 35662495
Role of Molecular Imaging with PET/MR Imaging in the Diagnosis and Management of Brain Tumors. Borja AJ, Saini J, Raynor WY, Ayubcha C, Werner TJ, Alavi A, Revheim ME, Nagaraj C. PET Clin. 2022 Jul;17(3):431-451. doi: 10.1016/j.cpet.2022.03.002. Epub 2022 May 31. PMID: 35662494
Prognostic significance of conventional and volumetric PET parameters with and without partial volume correction in the assessment of head and neck squamous cell carcinoma. Zirakchian Zadeh M, Asadollahi S, Kaghazchi F, Raynor WY, Mehdizadeh Seraj S, Werner TJ, Seierstad T, Korostoff J, Swisher-McClure S, Alavi A, Revheim ME. Nucl Med Commun.2022 Jul 1;43(7):800-806. doi: 10.1097/MNM.0000000000001573. Epub 2022 May 13. PMID: 35552334
Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells. Gómez Atria D, Gaudette BT, Londregan J, Kelly S, Perkey E, Allman A, Srivastava B, Koch U, Radtke F, Ludewig B, Siebel CW, Ryan RJ, Robertson TF, Burkhardt JK, Pear WS, Allman D, Maillard I. J Clin Invest. 2022 Jul 1;132(13):e158885. doi: 10.1172/JCI158885. PMID: 35579963
Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11. Harberts EM, Grubaugh D, Akuma DC, Shin S, Ernst RK, Brodsky IE. Infect Immun. 2022 Jul 14:e0020122. doi: 10.1128/iai.00201-22. Online ahead of print. PMID: 35862717
Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation. Alexander-Floyd J, Bass AR, Harberts EM, Grubaugh D, Buxbaum JD, Brodsky IE, Ernst RK, Shin S. Infect Immun. 2022 Jul 14:e0020822. doi: 10.1128/iai.00208-22. Online ahead of print. PMID: 35862709
Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells. Naseer N, Zhang J, Bauer R, Constant DA, Nice TJ, Brodsky IE, Rauch I, Shin S. Infect Immun. 2022 Jul 21;90(7):e0066321. doi: 10.1128/iai.00663-21. Epub 2022 Jun 9. PMID: 35678562
Simple and actionable preoperative prediction of postoperative healthcare needs of single-level lumbar fusion patients. Borja AJ, Farooqi AS, Golubovsky JL, Glauser G, Strouz K, Burkhardt JK, McClintock SD, Malhotra NR. J Neurosurg Spine. 2022 Jul 1:1-6. doi: 10.3171/2022.5.SPINE22282. Online ahead of print. PMID: 35901736
Herniation World Federation of Neurosurgical Societies Scale Improves Prediction of Outcome in Patients With Poor-Grade Aneurysmal Subarachnoid Hemorrhage. Raabe A, Beck J, Goldberg J, Z Graggen WJ, Branca M, Marbacher S, D'Alonzo D, Fandino J, Stienen MN, Neidert MC, Burkhardt JK, Regli L, Hlavica M, Seule M, Roethlisberger M, Guzman R, Zumofen DW, Maduri R, Daniel RT, El Rahal A, Corniola MV, Bijlenga P, Schaller K, Rölz R, Scheiwe C, Shah M, Heiland DH, Schnell O, Fung C. Stroke. 2022 Jul;53(7):2346-2351. doi: 10.1161/STROKEAHA.121.036699. Epub 2022 Mar 23. PMID: 35317612
The enigmatic roles of Anelloviridae and Redondoviridae in humans. Taylo LJ, Keeler EL, Bushman FD, Collman RG. Curr Opin Virol. 2022 Jul 20;55:101248. doi: 10.1016/j.coviro.2022.101248. Online ahead of print. PMID: 35870315
Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet⁺ B cells. Csomos K, Ujhazi B, Blazso P, Herrera JL, Tipton CM, Kawai T, Gordon S, Ellison M, Wu K, Stowell M, Haynes L, Cruz R, Zakota B, Nguyen J, Altrich M, Geier CB, Sharapova S, Dasso JF, Leiding JW, Smith G, Al-Herz W, de Barros Dorna M, Fadugba O, Fronkova E, Kanderova V, Svaton M, Henrickson SE, Hernandez JD, Kuijpers T, Kandilarova SM, Naumova E, Milota T, Sediva A, Moshous D, Neven B, Saco T, Sargur R, Savic S, Sleasman J, Sunkersett G, Ward BR, Komatsu M, Pittaluga S, Kumanovics A, Butte MJ, Cancro MP, Pillai S, Meffre E, Notarangelo LD, Walter JE. Nat Immunol. 2022 Jul 28. doi: 10.1038/s41590-022-01271-6. Online ahead of print. PMID: 35902638
Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors. Zhang H, Yu P, Tomar VS, Chen X, Atherton MJ, Lu Z, Zhang HG, Li S, Ortiz A, Gui J, Leu NA, Yan F, Blanco A, Meyer-Ficca ML, Meyer RG, Beiting DP, Li J, Nunez-Cruz S, O'Connor RS, Johnson LR, Minn AJ, George SS, Koumenis C, Diehl JA, Milone MC, Zheng H, Fuchs SY. Nat Cancer. 2022 Jul;3(7):808-820. doi: 10.1038/s43018-022-00383-0. Epub 2022 May 30. PMID: 35637402
Epidemiology, risk factors, and outcomes of lung retransplantation: An analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry. Harhay MO, Cherikh WS, Toll AE, Christie JD, Stehlik J, Chambers D, Hayes D Jr, Cantu E. J Heart Lung Transplant. 2022 Jul 5:S1053-2498(22)02022-8. doi: 10.1016/j.healun.2022.06.022. Online ahead of print. PMID: 35933297
Multianalyte Prognostic Signature Including Circulating Tumor DNA and Circulating Tumor Cells in Patients With Advanced Pancreatic Adenocarcinoma. Chapin WJ, Till JE, Hwang WT, Eads JR, Karasic TB, O'Dwyer PJ, Schneider CJ, Teitelbaum UR, Romeo J, Black TA, Christensen TE, Redlinger Tabery C, Anderson A, Slade M, LaRiviere M, Yee SS, Reiss KA, O'Hara MH, Carpenter EL. JCO Precis Oncol. 2022 Jul;6:e2200060. doi: 10.1200/PO.22.00060. PMID: 35939771
Transcriptional profiling of single tumour cells from pleural effusions reveals heterogeneity of epithelial to mesenchymal transition and extra-cellular matrix marker expression . Sen M, Hausler RM, Dulmage K, Black TA, Murphy W, Pletcher CH Jr, Wang L, Chen C, Yee SS, Bornheimer SJ, Maxwell KN, Stanger BZ, Moore JS, Thompson JC, Carpenter EL. Clin Transl Med. 2022 Jul;12(7):e888. doi: 10.1002/ctm2.888. PMID: 35811459
Biomarker Testing, Treatment Uptake, and Survival Among Patients With Urothelial Cancer Receiving Gene-Targeted Therapy. Nimgaonkar V, Hubbard RA, Carpenter EL, Mamtani R. JAMA Oncol. 2022 Jul 1;8(7):1070-1072. doi: 10.1001/jamaoncol.2022.1167. PMID: 35551582
Modulation of BCL-2 in both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T cell Immunotherapy against Cancer . Lee YG, Guruprasad P, Ghilardi G, Pajarillo R, Sauter CT, Patel R, Ballard HJ, Hong SJ, Chun I, Yang N, Amelsberg KV, Cummins KD, Svoboda J, Gill S, Chong EA, North K, Church SE, Fraietta JA, Chang WJ, Lacey SF, Lu XM, Zhang Y, Whig K, Schultz DC, Cherry S, Gerson J, Schuster SJ, Porazzi P, Ruella M. Cancer Discov. 2022 Jul 29:CD-21-1026. doi: 10.1158/2159-8290.CD-21-1026. Online ahead of print. PMID: 35904479
Altered adipose tissue macrophage populations in people with HIV on integrase inhibitor-containing ART. Vakili S, Paneru B, Guerrier CM, Miller J, Baumrin E, Forrestel A, Lynn K, Frank I, Lo Re V 3rd, Collman RG, Hill DA. AIDS. 2022 Jul 8. doi: 10.1097/QAD.0000000000003278. Online ahead of print. PMID: 35848549
Impact of atrial fibrillation recurrences during the blanking period following catheter ablation on long-term arrhythmia-free survival: a prospective study with continuous monitoring. Amankwah NA, Pothineni NVK, Guandalini G, Santangeli P, Schaller R, Supple GE, Deo R, Nazarian S, Lin D, Epstein AE, Dixit S, Callans DJ, Marchlinski FE, Frankel DS. J Interv Card Electrophysiol. 2022 Jul 7. doi: 10.1007/s10840-022-01291-0. Online ahead of print. PMID: 35794440
Decision-making Among Hepatitis C Virus-negative Transplant Candidates Offered Organs from Donors with HCV Infection. Saine ME, Schnellinger EM, Liu M, Diamond JM, Crespo MM, Prenner S, Potluri V, Bermudez C, Mentch H, Moore M, Besharatian B, Goldberg DS, Barg FK, Reese PP. Transplant Direct. 2022 Jul 19;8(8):e1341. doi: 10.1097/TXD.0000000000001341. eCollection 2022 Aug. PMID: 35923812
CXCL9 and CXCL10 plasma levels: Potential keys to unlocking CLAD risk . Shtraichman O, Diamond JM. Am J Transplant. 2022 Jul 2. doi: 10.1111/ajt.17135. Online ahead of print. PMID: 35778933
Adverse Pregnancy Outcomes in Nondiabetic Patients with an Elevated Early Pregnancy HbA1c. Bender WR, McCarthy C, Elovitz M, Parry S, Durnwald C. Am J Perinatol. 2022 Jul 5. doi: 10.1055/a-1877-8696. Online ahead of print. PMID: 35709738
Optimisation of anti-interleukin-6 therapy: Precision medicine through mathematical modelling. Rossi JF, Chiang HC, Lu ZY, Levon K, van Rhee F, Kanhai K, Fajgenbaum DC, Klein B. Front Immunol. 2022 Jul 19;13:919489. doi: 10.3389/fimmu.2022.919489. eCollection 2022. PMID: 35928820
Thrombocytopenia, anasarca, and severe inflammation. Montazeripouragha A, Campbell CM, Russell J, Medvedev N, Owen DR, Harris A, Donnellan F, McCormick I, Fajgenbaum DC, Chen LYC. Am J Hematol. 2022 Jul 6. doi: 10.1002/ajh.26651. Online ahead of print. PMID: 35794839
Siltuximab is associated with improved progression-free survival in idiopathic multicentric Castleman disease. van Rhee F, Rosenthal AL, Kanhai K, Martin RA, Nishimura KK, Hoering A, Fajgenbaum DC. Blood Adv. 2022 Jul 6:bloodadvances.2022007112. doi: 10.1182/bloodadvances.2022007112. Online ahead of print. PMID: 35793409
Idiopathic multicentric Castleman disease with arteriolar endotheliopathy and secondary haemophagocytosis. Campbell CM, Owen DR, Montazeripouragha A, McCormick I, Fajgenbaum DC, Chen LYC. Lancet Haematol. 2022 Jul;9(7):e546. doi: 10.1016/S2352-3026(22)00037-0. PMID: 35772433
The disease course of Castleman disease patients with fatal outcomes in the ACCELERATE registry. Fajgenbaum DC, Pierson SK, Kanhai K, Bagg A, Alapat D, Lim MS, Lechowicz MJ, Srkalovic G, Uldrick TS, van Rhee F; ACCELERATE Registry Team. Br J Haematol. 2022 Jul;198(2):307-316. doi: 10.1111/bjh.18214. Epub 2022 May 4. PMID: 35507638
Refractory eosinophilic esophagitis: what to do when the patient has not responded to proton pump inhibitors, steroids and diet. Strauss AL, Falk GW. Curr Opin Gastroenterol. 2022 Jul 1;38(4):395-401. doi: 10.1097/MOG.0000000000000842. PMID: 35762699
A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS. Gastroenterology. 2022 Jul;163(1):59-76. doi: 10.1053/j.gastro.2022.03.025. Epub 2022 May 20. PMID: 35606197
A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS. J Allergy Clin Immunol. 2022 Jul;150(1):33-47. doi: 10.1016/j.jaci.2022.03.015. Epub 2022 May 20. PMID: 35606166
Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation. Edwards KJ, Chang B, Babazada H, Lohith K, Park DH, Farwell MD, Sellmyer MA. Cancer Immunol Res. 2022 Jul 21:CIR-21-0874. doi: 10.1158/2326-6066.CIR-21-0874. Online ahead of print. PMID: 35862229
The Roles of Neutrophils Linking Periodontitis and Atherosclerotic Cardiovascular Diseases . Irwandi RA, Chiesa ST, Hajishengallis G, Papayannopoulos V, Deanfield JE, D'Aiuto F. Front Immunol. 2022 Jul 7;13:915081. doi: 10.3389/fimmu.2022.915081. eCollection 2022. PMID: 35874771
Inflammatory memory and comorbidities. Hajishengallis G, Chavakis T. Clin Transl Med. 2022 Jul;12(7):e984. doi: 10.1002/ctm2.984. PMID: 35839318
Mechanisms and Therapeutic Modulation of Neutrophil-Mediated Inflammation. Hajishengallis G, Chavakis T. J Dent Res. 2022 Jul 4:220345221107602. doi: 10.1177/00220345221107602. Online ahead of print. PMID: 35786033
Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses . Lyudovyk O, Kim JY, Qualls D, Hwee MA, Lin YH, Boutemine SR, Elhanati Y, Solovyov A, Douglas M, Chen E, Babady NE, Ramanathan L, Vedantam P, Bandlamudi C, Gouma S, Wong P, Hensley SE, Greenbaum B, Huang AC, Vardhana SA. Cancer Cell. 2022 Jul 11;40(7):738-753.e5. doi: 10.1016/j.ccell.2022.05.013. Epub 2022 May 30. PMID: 35679859
Role of Fluorodeoxyglucose-PET in Interventional Radiology. Zandifar A, Saucedo J, Vossough A, Alavi A, Hunt SJ. PET Clin. 2022 Jul;17(3):543-553. doi: 10.1016/j.cpet.2022.03.003. Epub 2022 May 31. PMID: 35662495
Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration . Balzer MS, Doke T, Yang YW, Aldridge DL, Hu H, Mai H, Mukhi D, Ma Z, Shrestha R, Palmer MB, Hunter CA, Susztak K. Nat Commun. 2022 Jul 11;13(1):4018. doi: 10.1038/s41467-022-31772-9. PMID: 35821371
CAR T-cell Therapy Meets Clonal Hematopoiesis. Uslu U, June CH. Blood Cancer Discov. 2022 Jul 27:OF1-OF3. doi: 10.1158/2643-3230.BCD-22-0067. Online ahead of print. PMID: 35896010
Potentiating adoptive cell therapy using synthetic IL-9 receptors. Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, Song D, Rommel PC, Radaelli E, Young RM, Leonard WJ, Ribas A, June CH, Garcia KC. Nature. 2022 Jul;607(7918):360-365. doi: 10.1038/s41586-022-04801-2. Epub 2022 Jun 8. PMID: 35676488
Multiethnic Investigation of Risk and Immune Determinants of COVID-19 Outcomes. Jun T, Mathew D, Sharma N, Nirenberg S, Huang HH, Kovatch P, Wherry EJ, Huang KL. Front Cell Infect Microbiol. 2022 Jul 22;12:933190. doi: 10.3389/fcimb.2022.933190. eCollection 2022. PMID: 35942057

June 2022

Day 4 vs. day 12 G-CSF administration following reduced intensity peripheral blood allogeneic stem cell transplant. Hatch RV, Freyer CW, Carulli A, Redline G, Babushok DV, Frey NV, Gill SI, Hexner EO, Luger SM, Martin ME, McCurdy SR, Perl AE, Porter DL, Pratz KW, Stadtmauer EA, Loren AW. J Oncol Pharm Pract. 2022 Jun;28(4):892-897. doi: 10.1177/10781552221080710. Epub 2022 Feb 22. PMID: 35191732
Surgical outcomes in survivors of childhood cancer undergoing thyroidectomy: A single-institution experience. Van Remortel BJ, Chehab L, Bauer AJ, Isaza A, Yimei L, Baumgarten HD, Franco AT, Laetsch TW, Kazahaya K, Adzick NS, Mostoufi-Moab S. Pediatr Blood Cancer. 2022 Jun;69(6):e29674. doi: 10.1002/pbc.29674. Epub 2022 Mar 26. PMID: 35338690
Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications. Hajishengallis G. Periodontol 2000. 2022 Jun;89(1):9-18. doi: 10.1111/prd.12430. Epub 2022 Mar 4. PMID: 35244969
Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities. Hajishengallis G, Li X, Divaris K, Chavakis T. Periodontol 2000. 2022 Jun;89(1):215-230. doi: 10.1111/prd.12421. Epub 2022 Mar 4. PMID: 35244943
Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System. Vazquez C, Jurado KA. Int J Mol Sci. 2022 Apr 5;23(7):4018. doi: 10.3390/ijms23074018. PMID: 35409387
Exploration of inhibitors of the bacterial LexA repressor-protease. Jaramillo AVC, Cory MB, Li A, Kohli RM, Wuest WM.Bioorg Med Chem Lett. 2022 Jun 1;65:128702. doi: 10.1016/j.bmcl.2022.128702. Epub 2022 Mar 26.PMID: 35351585
Day 4 vs. day 12 G-CSF administration following reduced intensity peripheral blood allogeneic stem cell transplant. Hatch RV, Freyer CW, Carulli A, Redline G, Babushok DV, Frey NV, Gill SI, Hexner EO, Luger SM, Martin ME, McCurdy SR, Perl AE, Porter DL, Pratz KW, Stadtmauer EA, Loren AW. J Oncol Pharm Pract. 2022 Jun;28(4):892-897. doi: 10.1177/10781552221080710. Epub 2022 Feb 22. PMID: 35191732
ACR-ACNM-ASTRO-SNMMI Practice Parameter for Lutetium-177 (Lu-177) DOTATATE Therapy . Love C, Desai NB, Abraham T, Banks KP, Bodei L, Boike T, Brown RKJ, Bushnell DL, DeBlanche LE, Dominello MM, Francis T, Grady EC, Hobbs RF, Hope TA, Kempf JS, Pryma DA, Rule W, Savir-Baruch B, Sethi I, Subramaniam RM, Xiao Y, Schechter NR. Clin Nucl Med. 2022 Jun 1;47(6):503-511. doi: 10.1097/RLU.0000000000004182. PMID: 35507433
Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial. Padrón LJ, Maurer DM, O'Hara MH, O'Reilly EM, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Yu JX, Pfeiffer SM, Spasic M, Xu J, Gherardini PF, Karakunnel J, Mick R, Alanio C, Byrne KT, Hollmann TJ, Moore JS, Jones DD, Tognetti M, Chen RO, Yang X, Salvador L, Wherry EJ, Dugan U, O'Donnell-Tormey J, Butterfield LH, Hubbard-Lucey VM, Ibrahim R, Fairchild J, Bucktrout S, LaVallee TM, Vonderheide RH. Nat Med. 2022 Jun 3. doi: 10.1038/s41591-022-01829-9. Online ahead of print. PMID: 35662283
The X in seX-biased immunity and autoimmune rheumatic disease. Jiwrajka N, Anguera MC. J Exp Med. 2022 Jun 6;219(6):e20211487. doi: 10.1084/jem.20211487. Epub 2022 May 5. PMID: 35510951
Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling.Giron LB, Peluso MJ, Ding J, Kenny G, Zilberstein NF, Koshy J, Hong KY, Rasmussen H, Miller GE, Bishehsari F, Balk RA, Moy JN, Hoh R, Lu S, Goldman AR, Tang HY, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Kelly JD, Wasse H, Martin JN, Liu Q, Keshavarzian A, Landay A, Deeks SG, Henrich TJ, Abdel-Mohsen M. JCI Insight. 2022 Jun 21:e160989. doi: 10.1172/jci.insight.160989. Online ahead of print. PMID: 35727635
Application of ¹⁸F-NaF-PET/CT in assessing age-related changes in the cervical spine. Park PSU, Raynor WY, Khurana N, Sun Y, Werner TJ, Høilund-Carlsen PF, Alavi A, Revheim ME. Quant Imaging Med Surg. 2022 Jun;12(6):3314-3324. doi: 10.21037/qims-21-1174. PMID: 35655822
Spatiotemporal Patterns of Substance P-Bound MRGPRX2 Reveal a Novel Connection Between Macropinosome Resolution and Secretory Granule Regeneration in Mast Cells. Lazki-Hagenbach P, Kleeblatt E, Ali H, Sagi-Eisenberg R. Front Immunol. 2022 Jun 28;13:892239. doi: 10.3389/fimmu.2022.892239. eCollection 2022. PMID: 35837385
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Alameh MG, Tombácz I, Bettini E, Lederer K, Sittplangkoon C, Wilmore JR, Gaudette BT, Soliman OY, Pine M, Hicks P, Manzoni TB, Knox JJ, Johnson JL, Laczkó D, Muramatsu H, Davis B, Meng W, Rosenfeld AM, Strohmeier S, Lin PJC, Mui BL, Tam YK, Karikó K, Jacquet A, Krammer F, Bates P, Cancro MP, Weissman D, Luning Prak ET, Allman D, Locci M, Pardi N. Immunity. 2022 Jun 14;55(6):1136-1138. doi: 10.1016/j.immuni.2022.05.007 .PMID: 35704995
Editorial: Role of Inflammation in Neurodegenerative Diseases. Koronyo-Hamaoui M, Gaire BP, Frautschy SA, Alvarez JI. Front Immunol. 2022 Jun 21;13:958487. doi: 10.3389/fimmu.2022.958487. eCollection 2022. PMID: 35799792
Understanding the Pathogenesis of Lateral Supratentorial Neurenteric Cysts in Close Proximity to Other Vascular Pathologies: A Case Report and Review of Embryology. Salem MM, Mccloskey K, Romeo D, Gubbiotti M, Su YS, DePace DM, Jankowitz BT, Burkhardt JK. Cureus. 2022 Jun 2;14(6):e25608. doi: 10.7759/cureus.25608. eCollection 2022 Jun. PMID: 35784991
Bailout Strategies for Abrupt Change in Woven Endobridge 17 Device Orientation After Detachments: Technical Note of 2 Anterior Communicating Artery Aneurysm Cases. Salem MM, Ali A, Riina HA, Burkhardt JK. World Neurosurg. 2022 Jun;162:68-72. doi: 10.1016/j.wneu.2022.03.081. Epub 2022 Mar 22. PMID: 35338022
Evaluating the state of the science for adeno-associated virus integration: An integrated perspective. Sabatino DE, Bushman FD, Chandler RJ, Crystal RG, Davidson BL, Dolmetsch R, Eggan KC, Gao G, Gil-Farina I, Kay MA, McCarty DM, Montini E, Ndu A, Yuan J; American Society of Gene and Cell Therapy (ASGCT) Working Group on AAV Integration. Mol Ther. 2022 Jun 10:S1525-0016(22)00364-1. doi: 10.1016/j.ymthe.2022.06.004. Online ahead of print. PMID: 35690906
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell Associated Neurotoxicity Syndrome in B-Cell ALL Patients Receiving CART19. Diorio C, Shraim R, Myers R, Behrens EM, Canna S, Bassiri H, Aplenc R, Burudpakdee C, Chen F, DiNofia AM, Gill S, Gonzalez V, Lambert MP, Barz Leahy A, Levine BL, Lindell RB, Maude SL, Melenhorst JJ, Newman H, Perazzelli J, Seif AE, Lacey SF, June CH, Barrett DM, Grupp SA, Teachey DT. Clin Cancer Res. 2022 Jun 15:clincanres.CCR-22-0822-E.2022-3-15 10:15:45.960. doi: 10.1158/1078-0432.CCR-22-0822. Online ahead of print. PMID: 35705524
Ex-vivo lung perfusion therapies: do they add value to organ donation? Lyengar A, Schiazza A, Cantu E 3rd. Curr Opin Organ Transplant. 2022 Jun 1;27(3):204-210. doi: 10.1097/MOT.0000000000000961. PMID: 35649110
Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis. Shallberg LA, Phan AT, Christian DA, Perry JA, Haskins BE, Beiting DP, Harris TH, Koshy AA, Hunter CA. PLoS Pathog. 2022 Jun 21;18(6):e1010296. doi: 10.1371/journal.ppat.1010296. eCollection 2022 Jun. PMID: 35727849
Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells. Lin H, Cheng K, Kubota H, Lan Y, Riedel SS, Kakiuchi K, Sasaki K, Bernt KM, Bartolomei MS, Luo M, Wang PJ. Genes Dev. 2022 Jun 1;36(11-12):752-763. doi: 10.1101/gad.349550.122. Epub 2022 Jun 23. PMID: 35738678
Publisher Correction: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA. Nat Genet. 2022 Jun;54(6):906. doi: 10.1038/s41588-022-01112-0. PMID: 35650318
Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells . Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA. Nat Genet. 2022 Jun;54(6):874-884. doi: 10.1038/s41588-022-01076-1. Epub 2022 May 26. PMID: 35618846
Development of a robust radiomic biomarker of progression-free survival in advanced non-small cell lung cancer patients treated with first-line immunotherapy . Singh A, Horng H, Roshkovan L, Weeks JK, Hershman M, Noël P, Luna JM, Cohen EA, Pantalone L, Shinohara RT, Bauml JM, Thompson JC, Aggarwal C, Carpenter EL, Katz SI, Kontos D. Sci Rep. 2022 Jun 15;12(1):9993. doi: 10.1038/s41598-022-14160-7. PMID: 35705618
ADP and Thromboxane Inhibitors Both Reduce Global Contraction of Clot Length, While Thromboxane Inhibition Attenuates Internal Aggregate Contraction. Trigani KT, DeCortin ME, Diamond SL. TH Open. 2022 Jun 13;6(2):e135-e143. doi: 10.1055/a-1832-9293. eCollection 2022 Apr. PMID: 35707619
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues. Dooling LJ, Saini K, Anlaş AA, Discher DE. Matrix Biol. 2022 Jun 25:S0945-053X(22)00086-5. doi: 10.1016/j.matbio.2022.06.006. Online ahead of print. PMID: 35764212
Nuclear mechanoprotection: From tissue atlases as blueprints to distinctive regulation of nuclear lamins. Wang M, Ivanovska I, Vashisth M, Discher DE. APL Bioeng. 2022 Jun 15;6(2):021504. doi: 10.1063/5.0080392. eCollection 2022 Jun. PMID: 35719698
Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms. Atyeo CG, Shook LL, Brigida S, De Guzman RM, Demidkin S, Muir C, Akinwunmi B, Baez AM, Sheehan ML, McSweeney E, Burns MD, Nayak R, Kumar MK, Patel CD, Fialkowski A, Cvrk D, Goldfarb IT, Yonker LM, Fasano A, Balazs AB, Elovitz MA, Gray KJ, Alter G, Edlow AG. Nat Commun. 2022 Jun 28;13(1):3571. doi: 10.1038/s41467-022-31169-8. PMID: 35764643
Prospective Evaluation of Cardiovascular Risk 10 Years After a Hypertensive Disorder of Pregnancy. Levine LD, Ky B, Chirinos JA, Koshinksi J, Arany Z, Riis V, Elovitz MA, Koelper N, Lewey J. J Am Coll Cardiol. 2022 Jun 21;79(24):2401-2411. doi: 10.1016/j.jacc.2022.03.383. PMID: 35710191
Lipid metabolism in the cervicovaginal space during pregnancy. Gerson KD, Elovitz MA, Burris HH. Am J Obstet Gynecol. 2022 Jun 6:S0002-9378(22)00445-8. doi: 10.1016/j.ajog.2022.05.067. Online ahead of print. PMID: 35679894
Anti-type I interferon antibodies as a cause of severe COVID-19. Fajgenbaum DC, Hayday AC, Rogers AJ, Towers GJ, Wack A, Zanoni I. Fac Rev. 2022 Jun 10;11:15. doi: 10.12703/r-01-0000010. eCollection 2022. PMID: 35812362
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression. Verginadis II, Avgousti H, Monslow J, Skoufos G, Chinga F, Kim K, Leli NM, Karagounis IV, Bell BI, Velalopoulou A, Salinas CS, Wu VS, Li Y, Ye J, Scott DA, Osterman AL, Sengupta A, Weljie A, Huang M, Zhang D, Fan Y, Radaelli E, Tobias JW, Rambow F, Karras P, Marine JC, Xu X, Hatzigeorgiou AG, Ryeom S, Diehl JA, Fuchs SY, Puré E, Koumenis C. Nat Cell Biol. 2022 Jun;24(6):940-953. doi: 10.1038/s41556-022-00918-8. Epub 2022 Jun 2. PMID: 35654839
A phase I trial of cyclosporine for hospitalized patients with COVID-19. Blumberg EA, Noll JH, Tebas P, Fraietta JA, Frank I, Marshall A, Chew A, Veloso EA, Carulli A, Rogal W, Gaymon AL, Schmidt AH, Barnette T, Jurek R, Martins R, Hudson BM, Chavda K, Bailey CM, Church SE, Noorchashm H, Hwang WT, June CH, Hexner EO. JCI Insight. 2022 Jun 8;7(11):e155682. doi: 10.1172/jci.insight.155682. PMID: 35536669
Association of S100A8/A9 with Lipid-Rich Necrotic Core and Treatment with Biologic Therapy in Patients with Psoriasis: Results from an Observational Cohort Study. Berg AR, Hong CG, Svirydava M, Li H, Parel PM, Florida E, O'Hagan R, Pantoja CJ, Lateef SS, Anzenberg P, Harrington CL, Ward G, Zhou W, Sorokin AV, Chen MY, Teague HL, Buckler AJ, Playford MP, Gelfand JM, Mehta NN. J Invest Dermatol. 2022 Jun 21:S0022-202X(22)01527-5. doi: 10.1016/j.jid.2022.05.1085. Online ahead of print. PMID: 35750149
Is It Prime Time for Statin Therapy in Psoriasis? Mehta NN, Gelfand JM. J Invest Dermatol. 2022 Jun;142(6):1519-1522. doi: 10.1016/j.jid.2022.02.020. PMID: 35598898
Regional specification of oral mucosal immunity. Williams DW, Hajishengallis G, Moutsopoulos NM. Sci Immunol. 2022 Jun 24;7(72):eabp8632. doi: 10.1126/sciimmunol.abp8632. Epub 2022 Jun 17. PMID: 35714199
C3-targeted host-modulation approaches to oral inflammatory conditions . Kajikawa T, Mastellos DC, Hasturk H, Kotsakis GA, Yancopoulou D, Lambris JD, Hajishengallis G. Semin Immunol. 2022 Jun 9:101608. doi: 10.1016/j.smim.2022.101608. Online ahead of print. PMID: 35691883
Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses . Christensen LM, Hancock WW. Front Immunol. 2022 Jun 20;13:909816. doi: 10.3389/fimmu.2022.909816. eCollection 2022. PMID: 35795673
The Selective Estrogen Receptor Modulator, Raloxifene, Is Protective Against Renal Ischemia-Reperfusion Injury. Hernandez P, O'Brien C, Concors SJ, Wang Z, Ge G, Hancock WW, Levine MH. Transplantation. 2022 Jun 3. doi: 10.1097/TP.0000000000004194. Online ahead of print. PMID: 35655356
Assessment of SARS-CoV-2 serostatus and hypertensive disorders of pregnancy. Triebwasser JE, Dhudasia MB, Mukhopadhyay S, Flannery DD, Gouma S, Hensley SE, Puopolo KM. Am J Obstet Gynecol. 2022 Jun 16:S0002-9378(22)00458-6. doi: 10.1016/j.ajog.2022.06.012. Online ahead of print. PMID: 35718110
Neighborhood Characteristics and Racial Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seropositivity in Pregnancy. Burris HH, Mullin AM, Dhudasia MB, Flannery DD, Mukhopadhyay S, Pfeifer MR, Woodford EC, Briker SM, Triebwasser JE, Morris JS, Montoya-Williams D, Gouma S, Hensley SE, Puopolo KM. Obstet Gynecol. 2022 Jun 1;139(6):1018-1026. doi: 10.1097/AOG.0000000000004791. Epub 2022 May 2. PMID: 35675599
The 2009 Pandemic H1N1 Hemagglutinin Stalk Remained Antigenically Stable after Circulating in Humans for a Decade. Christensen SR, Martin ET, Petrie JG, Monto AS, Hensley SE. J Virol. 2022 Jun 8;96(11):e0220021. doi: 10.1128/jvi.02200-21. Epub 2022 May 19. PMID: 35588275
Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction . Sterling JK, Baumann B, Foshe S, Voigt A, Guttha S, Alnemri A, McCright SJ, Li M, Zauhar RJ, Montezuma SR, Kapphahn RJ, Chavali VRM, Hill DA, Ferrington DA, Stambolian D, Mullins RF, Merrick D, Dunaief JL. Cell Rep. 2022 Jun 14;39(11):110942. doi: 10.1016/j.celrep.2022.110942. PMID: 35705048
A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection. Lawrence SP, Elser SE, Torben W, Blair RV, Pahar B, Aye PP, Schiro F, Szeltner D, Doyle-Meyers LA, Haggarty BS, Jordan APO, Romano J, Leslie GJ, Alvarez X, O'Connor DH, Wiseman RW, Fennessey CM, Li Y, Piatak M Jr, Lifson JD, LaBranche CC, Lackner AA, Keele BF, Maness NJ, Marsh M, Hoxie JA. PLoS Pathog. 2022 Jun 17;18(6):e1010507. doi: 10.1371/journal.ppat.1010507. eCollection 2022 Jun. PMID: 35714165
Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4. Welles HC, King HAD, Nettey L, Cavett N, Gorman J, Zhou T, Tsybovsky Y, Du R, Song K, Nguyen R, Ambrozak D, Ransier A, Schramm CA, Doria-Rose NA, Swanstrom AE, Hoxie JA, LaBranche C, Montefiori DC, Douek DC, Kwong PD, Mascola JR, Roederer M, Mason RD. PLoS Pathog. 2022 Jun 16;18(6):e1010574. doi: 10.1371/journal.ppat.1010574. eCollection 2022 Jun. PMID: 35709309
Preclinical platforms to study therapeutic efficacy of human γδ T cells. Ou L, Wang H, Huang H, Zhou Z, Lin Q, Guo Y, Mitchell T, Huang AC, Karakousis G, Schuchter L, Amaravadi R, Guo W, Salvino J, Herlyn M, Xu X. Clin Transl Med. 2022 Jun;12(6):e814. doi: 10.1002/ctm2.814. PMID: 35731974
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis . Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K. Nat Immunol. 2022 Jun;23(6):947-959. doi: 10.1038/s41590-022-01200-7. Epub 2022 May 12. PMID: 35552540
Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices - United States, 2022. Rao AK, Petersen BW, Whitehill F, Razeq JH, Isaacs SN, Merchlinsky MJ, Campos-Outcalt D, Morgan RL, Damon I, Sánchez PJ, Bell BP. MMWR Morb Mortal Wkly Rep. 2022 Jun 3;71(22):734-742. doi: 10.15585/mmwr.mm7122e1. PMID: 35653347
Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL . Bai Z, Woodhouse S, Zhao Z, Arya R, Govek K, Kim D, Lundh S, Baysoy A, Sun H, Deng Y, Xiao Y, Barrett DM, Myers RM, Grupp SA, June CH, Fan R, Camara PG, Melenhorst JJ. Sci Adv. 2022 Jun 10;8(23):eabj2820. doi: 10.1126/sciadv.abj2820. Epub 2022 Jun 8. PMID: 35675405

May 2022

Autoreactive CD8⁺ T cells are restrained by an exhaustion-like program that is maintained by LAG3 . Grebinoski S, Zhang Q, Cillo AR, Manne S, Xiao H, Brunazzi EA, Tabib T, Cardello C, Lian CG, Murphy GF, Lafyatis R, Wherry EJ, Das J, Workman CJ, Vignali DAA. Nat Immunol. 2022 May 26. doi: 10.1038/s41590-022-01210-5. Online ahead of print. PMID: 35618829
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine. Goel RR, Painter MM, Lundgreen KA, Apostolidis SA, Baxter AE, Giles JR, Mathew D, Pattekar A, Reynaldi A, Khoury DS, Gouma S, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Kc W, Oldridge DA, Erickson RI, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O, Drapeau EM, Davenport MP, Hensley SE, Bates P, Greenplate AR, Wherry EJ. Cell. 2022 May 26;185(11):1875-1887.e8. doi: 10.1016/j.cell.2022.04.009. Epub 2022 Apr 8. PMID: 35523182
Late renal allograft torsion in a pediatric transplant recipient. Hsiao WC, Abt P, Amaral S, Levine M, LaRosa C. Pediatr Transplant. 2022 May;26(3):e14210. doi: 10.1111/petr.14210. Epub 2021 Dec 15. PMID: 34907635
Mas-Related G Protein-Coupled Receptor-X2 and Its Role in Non-immunoglobulin E-Mediated Drug Hypersensitivity. Chompunud Na Ayudhya C, Ali H. Immunol Allergy Clin North Am. 2022 May;42(2):269-284. doi: 10.1016/j.iac.2021.12.003. Epub 2022 Mar 31. PMID: 35469618
Metformin for Treatment of Cytopenias in Children and Young Adults with Fanconi Anemia. Pollard J, Furutani E, Liu S, Esrick EB, Cohen LE, Bledsoe JR, Liu CW, Lu K, Ramírez MJ, Surrallés J, Malsch MM, Kuniholm A, Galvin A, Armant M, Kim AS, Ballotti K, Moreau LA, Zhou Y, Babushok DV, Boulad F, Carroll C, Hartung H, Hont A, Nakano TA, Olson TS, Sze SK, Thompson AA, Wlodarski MW, Gu X, Libermann TA, D'Andrea AD, Grompe MCP, Weller E, Shimamura A. Blood Adv. 2022 May 2:bloodadvances.2021006490. doi: 10.1182/bloodadvances.2021006490. Online ahead of print. PMID: 35500223
IL-1 receptor antagonist, MIS-C, and the peculiar autoimmunity of SARS-CoV-2. Bassiri H, Canna SW. Lancet Rheumatol. 2022 May;4(5):e305-e307. doi: 10.1016/S2665-9913(22)00090-X. Epub 2022 Mar 29. PMID: 35368385
Improvement in eosinophilic esophagitis when using dupilumab for other indications or compassionate use. Spergel BL, Ruffner MA, Godwin BC, Liacouras CA, Cianferoni A, Gober L, Hill DA, Brown-Whitehorn TF, Chaiboonma K, Aceves SA, Muir AM, Spergel JM. Ann Allergy Asthma Immunol. 2022 May;128(5):589-593. doi: 10.1016/j.anai.2022.01.019. Epub 2022 Jan 25. PMID: 35085819
The MHC-characterized Miniature Swine: Lessons Learned From a 40-Year Experience in Transplantation. Matar AJ, Sachs DH, Duran-Struuck R. Transplantation. 2022 May 1;106(5):928-937. doi: 10.1097/TP.0000000000003977. Epub 2021 Oct 29. PMID: 34720103
Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study. Shoda T, Collins MH, Rochman M, Wen T, Caldwell JM, Mack LE, Osswald GA, Besse JA, Haberman Y, Aceves SS, Arva NC, Capocelli KE, Chehade M, Davis CM, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Khoury P, Klion A, Menard-Katcher C, Leung J, Mukkada VA, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Furuta GT, Denson LA, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Diseases Researchers (CEGIR). Gastroenterology. 2022 May;162(6):1635-1649. doi: 10.1053/j.gastro.2022.01.022. Epub 2022 Jan 25. PMID: 35085569
CD8-Targeted PET Imaging of Tumor-Infiltrating T Cells in Patients with Cancer: A Phase I First-in-Humans Study of ⁸⁹Zr-Df-IAB22M2C, a Radiolabeled Anti-CD8 Minibody. Farwell MD, Gamache RF, Babazada H, Hellmann MD, Harding JJ, Korn R, Mascioni A, Le W, Wilson I, Gordon MS, Wu AM, Ulaner GA, Wolchok JD, Postow MA, Pandit-Taskar N. J Nucl Med. 2022 May;63(5):720-726. doi: 10.2967/jnumed.121.262485. Epub 2021 Aug 19. PMID: 34413145
Analysis of Specialist and Patient Perspectives on Strategies to Improve Cardiovascular Disease Prevention Among Persons With Psoriatic Disease. Barbieri JS, Beidas RS, Gondo GC, Fishman J, Williams NJ, Armstrong AW, Ogdie AR, Mehta N, Gelfand JM. JAMA Dermatol. 2022 Mar 1;158(3):252-259. doi: 10.1001/jamadermatol.2021.4467. PMID: 35044419
Nontraumatic Chylothorax and Chylopericardium: Diagnosis and Treatment Using an Algorithmic Approach Based on Novel Lymphatic Imaging. Gurevich A, Hur S, Singhal S, DiBardino D, Haas AR, Hansen-Flaschen JH, Nadolski G, Itkin M. Ann Am Thorac Soc. 2022 May;19(5):756-762. doi: 10.1513/AnnalsATS.202103-262OC. PMID: 34797746
Global Health and Interventional Radiology: Supporting Trainee Engagement and Diversity for Future Development. Matsumoto MM, Dixon R, Anton K, Hunt SJ, Kesselman A. J Vasc Interv Radiol. 2022 May;33(5):604-606.e2. doi: 10.1016/j.jvir.2022.01.005. Epub 2022 Jan 29. PMID: 35092852
Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation. Glinton KE, Ma W, Lantz C, Grigoryeva LS, DeBerge M, Liu X, Febbraio M, Kahn M, Oliver G, Thorp EB. J Clin Invest. 2022 May 2;132(9):e140685. doi: 10.1172/JCI140685. PMID: 35271504
Gene therapy for Fibrodysplasia Ossificans Progressiva (FOP): feasibility and obstacles. Eekhoff EMW, de Ruiter RD, Smilde BJ, Schoenmaker T, Vries TJ, Netelenbos C, Hsiao EC, Scott C, Haga N, Grunwald Z, De Cunto CL, Di Rocco M, Delai P, Diecidue R, Madhuri V, Cho TJ, Morhart R, Friedman C, Zasloff M, Pals G, Shim JH, Gao G, Kaplan F, Pignolo RJ, Micha D. Hum Gene Ther. 2022 May 2. doi: 10.1089/hum.2022.023. Online ahead of print. PMID: 35502479
Thrombin cleavage of osteopontin initiates osteopontin's tumor-promoting activity. Peraramelli S, Zhou Q, Zhou Q, Wanko B, Zhao L, Nishimura T, Leung TH, Mizuno S, Ito M, Myles T, Stulnig TM, Morser J, Leung LLK .J Thromb Haemost.2022 May;20(5):1256-1270. doi: 10.1111/jth.15663. Epub 2022 Feb 16. PMID: 35108449
β-Hydroxybutyrate suppresses colorectal cancer . Dmitrieva-Posocco O, Wong AC, Lundgren P, Golos AM, Descamps HC, Dohnalová L, Cramer Z, Tian Y, Yueh B, Eskiocak O, Egervari G, Lan Y, Liu J, Fan J, Kim J, Madhu B, Schneider KM, Khoziainova S, Andreeva N, Wang Q, Li N, Furth EE, Bailis W, Kelsen JR, Hamilton KE, Kaestner KH, Berger SL, Epstein JA, Jain R, Li M, Beyaz S, Lengner CJ, Katona BW, Grivennikov SI, Thaiss CA, Levy M. Nature. 2022 May;605(7908):160-165. doi: 10.1038/s41586-022-04649-6. Epub 2022 Apr 27. PMID: 35477756
Real-world effectiveness of CPX-351 vs venetoclax and azacitidine in acute myeloid leukemia. Matthews AH, Perl AE, Luger SM, Loren AW, Gill SI, Porter DL, Babushok DV, Maillard I, Carroll MP, Frey NV, Hexner E, Martin ME, McCurdy SR, Stadtmauer EA, Paralkar VR, Jordan Bruno X, Hwang WT, Margolis D, Pratz KW. Blood Adv. 2022 May 4:bloodadvances.2022007265. doi: 10.1182/bloodadvances.2022007265. Online ahead of print. PMID: 35507945
Cardiovascular Risk Factors and Target Organ Damage in Adolescents: The SHIP AHOY Study. Price JJ, Urbina EM, Carlin K, Becker R, Daniels SR, Falkner BE, Ferguson M, Hanevold C, Hooper SR, Ingelfinger JR, Lande MB, Martin LJ, Meyers K, Mitsnefes M, Rosner B, Samuels J, Flynn JT. Pediatrics. 2022 May 3:e2021054201. doi: 10.1542/peds.2021-054201. Online ahead of print. PMID: 35502610
Use of hyphenated analytical techniques to identify the bioactive constituents of Gunnera perpensa L., a South African medicinal plant, which potently inhibit SARS-CoV-2 spike glycoprotein-host ACE2 binding. Invernizzi L, Moyo P, Cassel J, Isaacs FJ, Salvino JM, Montaner LJ, Tietjen I, Maharaj V. Anal Bioanal Chem. 2022 May;414(13):3971-3985. doi: 10.1007/s00216-022-04041-3. Epub 2022 Apr 14. PMID: 35419694
EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells. Zhou Y, Petrovic J, Zhao J, Zhang W, Bigdeli A, Zhang Z, Berger SL, Pear WS, Faryabi RB. Mol Cell. 2022 Mar 3;82(5):1003-1020.e15. doi: 10.1016/j.molcel.2022.01.015. Epub 2022 Feb 18. PMID: 35182476
Immunologic and Infectious Concerns in Uterus Transplantation. Porrett PM, Nellore A. Clin Obstet Gynecol. 2022 Mar 1;65(1):37-43. doi: 10.1097/GRF.0000000000000686. PMID: 35045023
Real-world effectiveness of CPX-351 vs venetoclax and azacitidine in acute myeloid leukemia. Matthews AH, Perl AE, Luger SM, Loren AW, Gill SI, Porter DL, Babushok DV, Maillard I, Carroll MP, Frey NV, Hexner E, Martin ME, McCurdy SR, Stadtmauer EA, Paralkar VR, Jordan Bruno X, Hwang WT, Margolis D, Pratz KW. Blood Adv. 2022 May 4:bloodadvances.2022007265. doi: 10.1182/bloodadvances.2022007265. Online ahead of print. PMID: 35507945
Improvement in eosinophilic esophagitis when using dupilumab for other indications or compassionate use. Spergel BL, Ruffner MA, Godwin BC, Liacouras CA, Cianferoni A, Gober L, Hill DA, Brown-Whitehorn TF, Chaiboonma K, Aceves SA, Muir AM, Spergel JM. Ann Allergy Asthma Immunol. 2022 May;128(5):589-593. doi: 10.1016/j.anai.2022.01.019. Epub 2022 Jan 25. PMID: 35085819
Radiation therapy for head and neck cancer leads to gingival recession associated with dental caries. Lalla RV, Treister NS, Sollecito TP, Schmidt BL, Patton LL, Helgeson ES, Lin A, Rybczyk C, Dowsett R, Hegde U, Boyd TS, Duplinsky TG, Brennan MT. Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 May;133(5):539-546. doi: 10.1016/j.oooo.2022.01.016. Epub 2022 Jan 31. PMID: 35304084
Sex-based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children's Oncology Group report. Gupta S, Teachey DT, Chen Z, Rabin KR, Dunsmore KP, Larsen EC, Maloney KW, Mattano LA Jr, Winter SS, Carroll AJ, Heerema NA, Borowitz MJ, Wood BL, Carroll WL, Raetz EA, Winick NJ, Loh ML, Hunger SP, Devidas M. Cancer. 2022 May 1;128(9):1863-1870. doi: 10.1002/cncr.34150. Epub 2022 Feb 24. PMID: 35201611
Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans. Gilbertson SE, Walter HC, Gardner K, Wren SN, Vahedi G, Weinmann AS. Cell Rep. 2022 May 3;39(5):110769. doi: 10.1016/j.celrep.2022.110769. PMID: 35508135
CMV infection and management among pediatric solid organ transplant recipients. Downes KJ, Sharova A, Boge CLK, Vader D, Mitrou M, Hayes M, Galetaki DM, Gianchetti L, Vella LA, Li Y. Pediatr Transplant. 2022 May;26(3):e14220. doi: 10.1111/petr.14220. Epub 2022 Jan 6. PMID: 34994041
Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates. Walters JN, Schouest B, Patel A, Reuschel EL, Schultheis K, Parzych E, Maricic I, Gary EN, Purwar M, Andrade VM, Doan A, Elwood D, Eblimit Z, Nguyen B, Frase D, Zaidi FI, Kulkarni A, Generotti A, Joseph Kim J, Humeau LM, Ramos SJ, Smith TRF, Weiner DB, Broderick KE. Vaccine. 2022 May 9;40(21):2960-2969. doi: 10.1016/j.vaccine.2022.03.060. Epub 2022 Apr 4. PMID: 35428500
Immunological features in de novo and recurrent glioblastoma associate with survival outcomes. Alanio C, Binder ZA, Chang RB, Nasrallah MP, Delman D, Li JH, Tang OY, Zhang LY, Zhang JV, Wherry EJ, O'Rourke DM, Beatty GL. Cancer Immunol Res. 2022 May 4:canimm.CIR-21-1050-E.2021. doi: 10.1158/2326-6066.CIR-21-1050. Online ahead of print. PMID: 35507919
NHLBI Report: Impact of Sex and Gender on Autoimmune Lung Disease, Opportunities for Future Research. Volkmann ER, Siegfried J, Lahm T, Ventetuolo CE, Mathai SC, Steen V, Herzog EL, Shansky R, Anguera MC, Danoff SK, Giles JT, Lee YC, Drake W, Maier LA, Lachowicz-Scroggins M, Park H, Banerjee K, Fessel J, Reineck L, Vuga L, Crouser E, Feghali-Bostwick C. Am J Respir Crit Care Med. 2022 May 13. doi: 10.1164/rccm.202112-2746PP. Online ahead of print. PMID: 35549658
Editorial: Immunoglobulin Glycosylation Analysis: State-of-the-Art Methods and Applications in Immunology. Trbojević-Akmačić I, Abdel-Mohsen M, Falck D, Rapp E. Front Immunol. 2022 May 20;13:923393. doi: 10.3389/fimmu.2022.923393. eCollection 2022. PMID: 35669775
Trends and Outcomes of Primary, Rescue, and Adjunct Middle Meningeal Artery Embolization for Chronic Subdural Hematomas. Nia AM, Srinivasan VM, Siddiq F, Thomas A, Burkhardt JK, Lall RR, Kan P. World Neurosurg. 2022 May 10:S1878-8750(22)00598-8. doi: 10.1016/j.wneu.2022.05.011. Online ahead of print. PMID: 35552029
The pediatric virome in health and disease. Liang G, Gao H, Bushman FD. Cell Host Microbe. 2022 May 11;30(5):639-649. doi: 10.1016/j.chom.2022.04.006. PMID: 35550667
A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. Gibson AR, Sateriale A, Dumaine JE, Engiles JB, Pardy RD, Gullicksrud JA, O'Dea KM, Doench JG, Beiting DP, Hunter CA, Striepen B. PLoS Pathog. 2022 May 18;18(5):e1010003. doi: 10.1371/journal.ppat.1010003. eCollection 2022 May. PMID: 35584177
Reestablishment of spermatogenesis after more than 20 years of cryopreservation of rat spermatogonial stem cells reveals an important impact in differentiation capacity. Whelan EC, Yang F, Avarbock MR, Sullivan MC, Beiting DP, Brinster RL. PLoS Biol. 2022 May 10;20(5):e3001618. doi: 10.1371/journal.pbio.3001618. eCollection 2022 May. PMID: 35536782
Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression. Wakabayashi A, Kihiu M, Sharma M, Thrasher AJ, Saari MS, Quesnel-Vallieres M, Abdulmalik O, Peslak SA, Khandros E, Keller CA, Giardine BM, Barash Y, Hardison RC, Shi J, Blobel GA. Blood Adv. 2022 May 27:bloodadvances.2022007904. doi: 10.1182/bloodadvances.2022007904. Online ahead of print. PMID: 35622975
Extracellular Vesicle-Based Multianalyte Liquid Biopsy as a Diagnostic for Cancer. Lin AA, Nimgaonkar V, Issadore D, Carpenter EL. Annu Rev Biomed Data Sci. 2022 May 13. doi: 10.1146/annurev-biodatasci-122120-113218. Online ahead of print. PMID: 35562850
Trafficking and persistence of alloantigen-specific chimeric antigen receptor regulatory T cells in Cynomolgus macaque. Ellis GI, Coker KE, Winn DW, Deng MZ, Shukla D, Bhoj V, Milone MC, Wang W, Liu C, Naji A, Duran-Struuck R, Riley JL. Cell Rep Med. 2022 May 17;3(5):100614. doi: 10.1016/j.xcrm.2022.100614. Epub 2022 May 11. PMID: 35551746
Racism and perinatal health inequities research: where we have been and where we should go. Headen IE, Elovitz MA, Battarbee AN, Lo JO, Debbink MP. Am J Obstet Gynecol. 2022 May 18:S0002-9378(22)00377-5. doi: 10.1016/j.ajog.2022.05.033. Online ahead of print. PMID: 35597277
Case 16-2022: A 55-Year-Old Man with Fevers, Night Sweats, and a Mediastinal Mass. Fajgenbaum DC, Goiffon RJ, Soumerai JD, Harris CK. N Engl J Med. 2022 May 26;386(21):2036-2048. doi: 10.1056/NEJMcpc2115849. PMID: 35613025
Microbiota and maintenance of skin barrier function. Harris-Tryon TA, Grice EA. Science. 2022 May 27;376(6596):940-945. doi: 10.1126/science.abo0693. Epub 2022 May 26. PMID: 35617415
Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages. Zankharia U, Yadav A, Yi Y, Hahn BH, Collman RG. J Leukoc Biol. 2022 May 27:10.1002/JLB.4COVA1121-579RR. doi: 10.1002/JLB.4COVA1121-579RR. Online ahead of print. PMID: 35621385
Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021-22 Northern Hemisphere influenza season . Bolton MJ, Ort JT, McBride R, Swanson NJ, Wilson J, Awofolaju M, Furey C, Greenplate AR, Drapeau EM, Pekosz A, Paulson JC, Hensley SE. Cell Rep. 2022 May 31;39(9):110897. doi: 10.1016/j.celrep.2022.110897. PMID: 35649381
The ubiquitin ligase Cul5 regulates CD4⁺ T cell fate choice and allergic inflammation . Kumar B, Field NS, Kim DD, Dar AA, Chen Y, Suresh A, Pastore CF, Hung LY, Porter N, Sawada K, Shah P, Elbulok O, Moser EK, Herbert DR, Oliver PM. Nat Commun. 2022 May 19;13(1):2786. doi: 10.1038/s41467-022-30437-x. PMID: 35589717
"Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity". Inclan-Rico JM, Rossi HL, Herbert DR. Mucosal Immunol. 2022 May 10. doi: 10.1038/s41385-022-00518-7. Online ahead of print. PMID: 35538230

April 2022

Viral and Host Biomarkers of HIV Remission Post Treatment Interruption. Giron LB, Abdel-Mohsen M. Curr HIV/AIDS Rep. 2022 Apr 19. doi: 10.1007/s11904-022-00607-z. Online ahead of print.PMID: 35438384
Molecular imaging in management of colorectal metastases by the interventional oncologist. Hunt S, Zandifar A, Alavi A. Int J Hyperthermia. 2022;39(1):675-681. doi: 10.1080/02656736.2021.1998657.PMID: 35465814
Aducanumab-Related Amyloid-Related Imaging Abnormalities: Paean or Lament? Høilund-Carlsen PF, Werner TJ, Alavi A, Revheim ME. Clin Nucl Med. 2022 Apr 22. doi: 10.1097/RLU.0000000000004250. Online ahead of print.PMID: 35452007
Can Target-to-Background Ratio Measurement Lead to Detection and Accurate Quantification of Atherosclerosis With FDG PET? Likely Not . Alavi A, Werner TJ, Høilund-Carlsen PF, Revheim ME. Clin Nucl Med. 2022 Apr 5. doi: 10.1097/RLU.0000000000004131. Online ahead of print.PMID: 35384906
A review of different methods used for quantification and assessment of FDG-PET/CT in multiple myeloma. Zirakchian Zadeh M, Ayubcha C, Raynor WY, Werner TJ, Alavi A. Nucl Med Commun. 2022 Apr 1;43(4):378-391. doi: 10.1097/MNM.0000000000001528.PMID: 35102074
Long Noncoding RNAs That Function in Nutrition: Lnc-ing Nutritional Cues to Metabolic Pathways. Lovell CD, Anguera MC. Annu Rev Nutr. 2022 Apr 18. doi: 10.1146/annurev-nutr-062220-030244. Online ahead of print.PMID: 35436418
Herpes Simplex Virus (HSV)-2 Variation Contributes to Neurovirulence During Neonatal Infection. Hayes CK, Villota CK, McEnany FB, Cerón S, Awasthi S, Szpara ML, Friedman HM, Leib DA, Longnecker R, Weitzman MD, Akhtar LN. J Infect Dis. 2022 Apr 22:jiac151. doi: 10.1093/infdis/jiac151. Online ahead of print.PMID: 35451492
An mRNA vaccine to prevent genital herpes. Awasthi S, Friedman HM. Transl Res. 2022 Apr;242:56-65. doi: 10.1016/j.trsl.2021.12.006. Epub 2021 Dec 23.PMID: 34954087
β-Hydroxybutyrate suppresses colorectal cancer. Dmitrieva-Posocco O, Wong AC, Lundgren P, Golos AM, Descamps HC, Dohnalová L, Cramer Z, Tian Y, Yueh B, Eskiocak O, Egervari G, Lan Y, Liu J, Fan J, Kim J, Madhu B, Schneider KM, Khoziainova S, Andreeva N, Wang Q, Li N, Furth EE, Bailis W, Kelsen JR, Hamilton KE, Kaestner KH, Berger SL, Epstein JA, Jain R, Li M, Beyaz S, Lengner CJ, Katona BW, Grivennikov SI, Thaiss CA, Levy M. Nature. 2022 Apr 27. doi: 10.1038/s41586-022-04649-6. Online ahead of print.PMID: 35477756
The metabolic potential of the paediatric-onset multiple sclerosis gut microbiome. Mirza AI, Zhu F, Knox N, Forbes JD, Bonner C, Van Domselaar G, Bernstein CN, Graham M, Marrie RA, Hart J, Yeh EA, Arnold DL, Bar-Or A, O'Mahony J, Zhao Y, Hsiao W, Banwell B, Waubant E, Tremlett H. Mult Scler Relat Disord. 2022 Apr 23;63:103829. doi: 10.1016/j.msard.2022.103829. Online ahead of print.PMID: 35500534
Long-term efficacy and safety of siponimod in patients with secondary progressive multiple sclerosis: Analysis of EXPAND core and extension data up to >5 years. Cree BA, Arnold DL, Fox RJ, Gold R, Vermersch P, Benedict RH, Bar-Or A, Piani-Meier D, Rouyrre N, Ritter S, Kilaru A, Karlsson G, Giovannoni G, Kappos L. Mult Scler. 2022 Apr 5:13524585221083194. doi: 10.1177/13524585221083194. Online ahead of print.PMID: 35380078
BTK inhibition limits B-cell-T-cell interaction through modulation of B-cell metabolism: implications for multiple sclerosis therapy . Li R, Tang H, Burns JC, Hopkins BT, Le Coz C, Zhang B, de Barcelos IP, Romberg N, Goldstein AC, Banwell BL, Luning Prak ET, Mingueneau M, Bar-Or A. Acta Neuropathol. 2022 Apr;143(4):505-521. doi: 10.1007/s00401-022-02411-w. Epub 2022 Mar 18.PMID: 35303161
Paraneoplastic myasthenia gravis and pemphigus associated with follicular dendritic cell sarcoma leading to cardiorespiratory collapse in a 7-year-old. Lynch HM, Beslow LA, Treat JR, Corcoran A, Lin JH, Gunawardena N, Maris JM, Behrens EM. Pediatr Blood Cancer. 2022 Apr 29:e29723. doi: 10.1002/pbc.29723. Online ahead of print.PMID: 35484988
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 3. Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Kernan KF, Schulert GS, Seo P, Son MBF, Tremoulet AH, VanderPluym C, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta JJ. Arthritis Rheumatol. 2022 Apr;74(4):e1-e20. doi: 10.1002/art.42062. Epub 2022 Feb 3.PMID: 35118829
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia. Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K. Blood. 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442.PMID: 34864916
Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression. Topfer SK, Feng R, Huang P, Ly LC, Martyn GE, Blobel GA, Weiss MJ, Quinlan KGR, Crossley M. Blood. 2022 Apr 7;139(14):2107-2118. doi: 10.1182/blood.2021014205.PMID: 35090172
PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Perry JA, Shallberg L, Clark JT, Gullicksrud JA, DeLong JH, Douglas BB, Hart AP, Lanzar Z, O'Dea K, Konradt C, Park J, Kuchroo JR, Grubaugh D, Zaretsky AG, Brodsky IE, Malefyt RW, Christian DA, Sharpe AH, Hunter CA. Nat Immunol. 2022 Apr 18. doi: 10.1038/s41590-022-01170-w. Online ahead of print.PMID: 35437326
The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade. Cucolo L, Chen Q, Qiu J, Yu Y, Klapholz M, Budinich KA, Zhang Z, Shao Y, Brodsky IE, Jordan MS, Gilliland DG, Zhang NR, Shi J, Minn AJ. Immunity. 2022 Apr 12;55(4):671-685.e10. doi: 10.1016/j.immuni.2022.03.007.PMID: 35417675
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial. Narayan V, Barber-Rotenberg JS, Jung IY, Lacey SF, Rech AJ, Davis MM, Hwang WT, Lal P, Carpenter EL, Maude SL, Plesa G, Vapiwala N, Chew A, Moniak M, Sebro RA, Farwell MD, Marshall A, Gilmore J, Lledo L, Dengel K, Church SE, Hether TD, Xu J, Gohil M, Buckingham TH, Yee SS, Gonzalez VE, Kulikovskaya I, Chen F, Tian L, Tien K, Gladney W, Nobles CL, Raymond HE; Prostate Cancer Cellular Therapy Program Investigators, Hexner EO, Siegel DL, Bushman FD, June CH, Fraietta JA, Haas NB. Nat Med. 2022 Apr;28(4):724-734. doi: 10.1038/s41591-022-01726-1. Epub 2022 Mar 21.PMID: 35314843
Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Nature. 2022 Apr;604(7904):120-126. doi: 10.1038/s41586-022-04552-0. Epub 2022 Mar 30.PMID: 35355013
Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia . Galán-Díez M, Borot F, Ali AM, Zhao J, Gil-Iturbe E, Shan X, Luo N, Liu Y, Huang XP, Bisikirska B, Labella R, Kurland I, Roth BL, Quick M, Mukherjee S, Rabadán R, Carroll M, Raza A, Kousteni S. Cancer Discov. 2022 Apr 1;12(4):1106-1127. doi: 10.1158/2159-8290.CD-21-0692.PMID: 35046097
Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation. Zhong L, Yao L, Holdreith N, Yu W, Gui T, Miao Z, Elkaim Y, Li M, Gong Y, Pacifici M, Maity A, Busch TM, Joeng KS, Cengel K, Seale P, Tong W, Qin L. JCI Insight. 2022 Apr 8;7(7):e150323. doi: 10.1172/jci.insight.150323.PMID: 35393948
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. Verma A, Tsao NL, Thomann LO, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford DC, Efird JT, Huffman JE, Hung A, Ivey KL, Levin MG, Lynch J, Natarajan P, Pyarajan S, Bick AG, Costa L, Genovese G, Hauger R, Madduri R, Pathak GA, Polimanti R, Voight B, Vujkovic M, Zekavat SM, Zhao H, Ritchie MD; VA Million Veteran Program COVID-19 Science Initiative, Chang KM, Cho K, Casas JP, Tsao PS, Gaziano JM, O'Donnell C, Damrauer SM, Liao KP. PLoS Genet. 2022 Apr 28;18(4):e1010113. doi: 10.1371/journal.pgen.1010113. eCollection 2022 Apr.PMID: 35482673
Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure. Clarke SL, Tcheandjieu C, Hilliard AT, Lee KM, Lynch J, Chang KM, Miller D, Knowles JW, O'Donnell C, Tsao PS, Rader DJ, Wilson PW, Sun YV, Gaziano JM, Assimes TL; VA Million Veteran Program. Circ Genom Precis Med. 2022 Apr;15(2):e003501. doi: 10.1161/CIRCGEN.121.003501. Epub 2022 Feb 10.PMID: 35143253
APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program. Hung AM, Shah SC, Bick AG, Yu Z, Chen HC, Hunt CM, Wendt F, Wilson O, Greevy RA, Chung CP, Suzuki A, Ho YL, Akwo E, Polimanti R, Zhou J, Reaven P, Tsao PS, Gaziano JM, Huffman JE, Joseph J, Luoh SW, Iyengar S, Chang KM, Casas JP, Matheny ME, O'Donnell CJ, Cho K, Tao R, Susztak K, Robinson-Cohen C, Tuteja S, Siew ED; VA Million Veteran Program COVID-19 Science Initiative. JAMA Intern Med. 2022 Apr 1;182(4):386-395. doi: 10.1001/jamainternmed.2021.8538.PMID: 35089317
Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Schultz DC, Johnson RM, Ayyanathan K, Miller J, Whig K, Kamalia B, Dittmar M, Weston S, Hammond HL, Dillen C, Ardanuy J, Taylor L, Lee JS, Li M, Lee E, Shoffler C, Petucci C, Constant S, Ferrer M, Thaiss CA, Frieman MB, Cherry S. Nature. 2022 Apr;604(7904):134-140. doi: 10.1038/s41586-022-04482-x. Epub 2022 Feb 7.PMID: 35130559
Current Beliefs and Practices Regarding the Management of Obesity in Patients with Progressive Interstitial Lung Disease. Anderson MR, Aronson KI, Diamond JM, Christie JD, Singer JP. Ann Am Thorac Soc. 2022 Apr 15. doi: 10.1513/AnnalsATS.202201-019RL. Online ahead of print.PMID: 35427212
Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Nature. 2022 Apr;604(7904):120-126. doi: 10.1038/s41586-022-04552-0. Epub 2022 Mar 30.PMID: 35355013
Saliva vs upper respiratory swabs: Equivalent for SARS-CoV-2 university screening while saliva positivity is prolonged post-symptom onset in COVID-19 hospitalized patients . El-Sharkawy F, Tang CN, Fitzgerald AS, Khatib LA, Graham-Wooten J, Glaser L, Collman RG, Van Deerlin VM, Herlihy SE. J Mol Diagn. 2022 Apr 27:S1525-1578(22)00104-0. doi: 10.1016/j.jmoldx.2022.03.012. Online ahead of print.PMID: 35489695
Epigenetic Landscape of HIV-1 Infection in Primary Human Macrophage. Lu F, Zankharia U, Vladimirova O, Yi Y, Collman RG, Lieberman PM. J Virol. 2022 Apr 13;96(7):e0016222. doi: 10.1128/jvi.00162-22. Epub 2022 Mar 23.PMID: 35319230
Editorial: Antimicrobial Peptides: Molecular Design, Structure-Function Relationship, and Biosynthesis Optimization . Hao Y, Wang J, de la Fuente-Nunez C, Franco OL. Front Microbiol. 2022 Apr 11;13:888540. doi: 10.3389/fmicb.2022.888540. eCollection 2022.PMID: 35495692
Autonomous Treatment of Bacterial Infections in Vivo Using Antimicrobial Micro- and Nanomotors . Arqué X, Torres MDT, Patiño T, Boaro A, Sánchez S, de la Fuente-Nunez C. ACS Nano. 2022 Apr 29. doi: 10.1021/acsnano.1c11013. Online ahead of print.PMID: 35486889
Detection of SARS-CoV-2 with RAPID: A prospective cohort study. Torres MDT, de Lima LF, Ferreira AL, de Araujo WR, Callahan P, Dávila A Jr, Abella BS, de la Fuente-Nunez C. iScience. 2022 Apr 15;25(4):104055. doi: 10.1016/j.isci.2022.104055. Epub 2022 Mar 11.PMID: 35291265
Subcutaneous Implantable Cardioverter-defibrillator Explantation-A Single Tertiary Center Experience . Pothineni NVK, Cherian T, Patel N, Smietana J, Frankel DS, Deo R, Epstein AE, Marchlinski FE, Schaller RD. J Innov Card Rhythm Manag. 2022 Apr 15;13(4):4947-4953. doi: 10.19102/icrm.2022.130407. eCollection 2022 Apr.PMID: 35474857
Effect of Transcutaneous Magnetic Stimulation in Patients With Ventricular Tachycardia Storm: A Randomized Clinical Trial. Markman TM, Pothineni NVK, Zghaib T, Smietana J, McBride D, Amankwah NA, Linn KA, Kumareswaran R, Hyman M, Arkles J, Santangeli P, Schaller RD, Supple GE, Frankel DS, Deo R, Lin D, Riley MP, Epstein AE, Callans DJ, Marchlinski FE, Hamilton R, Nazarian S. JAMA Cardiol. 2022 Apr 1;7(4):445-449. doi: 10.1001/jamacardio.2021.6000.PMID: 35171197
Use of elexacaftor/tezacaftor/ivacaftor among cystic fibrosis lung transplant recipients. Ramos KJ, Guimbellot JS, Valapour M, Bartlett LE, Wai TH, Goss CH, Pilewski JM, Faro A, Diamond JM; CFLTC Study Group. J Cyst Fibros. 2022 Apr 23:S1569-1993(22)00098-4. doi: 10.1016/j.jcf.2022.04.009. Online ahead of print.PMID: 35474016
Don't Inhale: Acute Respiratory Distress Syndrome Risk and Tobacco Exposure in Patients with Sepsis. Diamond JM. Am J Respir Crit Care Med. 2022 Apr 15;205(8):866-867. doi: 10.1164/rccm.202201-0034ED.PMID: 35130469
CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies. Andrechak JC, Dooling LJ, Tobin MP, Zhang W, Hayes BH, Lee JY, Jin X, Irianto J, Discher DE. Cancers (Basel). 2022 Apr 11;14(8):1930. doi: 10.3390/cancers14081930.PMID: 35454837
Prevalence of Prodromal Symptoms of Parkinson's Disease in the Late Middle-Aged Population . Roos DS, Klein M, Deeg DJH, Doty RL, Berendse HW. .J Parkinsons Dis. 2022;12(3):967-974. doi: 10.3233/JPD-213007.PMID: 35180132
Second trimester short cervix is associated with decreased abundance of cervicovaginal lipid metabolites. Gerson KD, Yang N, Anton L, Levy M, Ravel J, Elovitz MA, Burris HH. Am J Obstet Gynecol. 2022 Apr 22:S0002-9378(22)00310-6. doi: 10.1016/j.ajog.2022.04.031. Online ahead of print.PMID: 35469813
Effectiveness of a Text-Based Gamification Intervention to Improve Physical Activity Among Postpartum Individuals With Hypertensive Disorders of Pregnancy: A Randomized Clinical Trial. Lewey J, Murphy S, Zhang D, Putt ME, Elovitz MA, Riis V, Patel MS, Levine LD. .JAMA Cardiol. 2022 Apr 20:e220553. doi: 10.1001/jamacardio.2022.0553. Online ahead of print. PMID: 35442393
Association of COVID-19 and Endemic Systemic Racism With Postpartum Anxiety and Depression Among Black Birthing Individuals. Njoroge WFM, White LK, Waller R, Forkpa M, Himes MM, Morgan K, Seidlitz J, Chaiyachati BH, Barzilay R, Kornfield SL, Parish-Morris J, Rodriguez Y, Riis V, Burris HH, Elovitz MA, Gur RE. JAMA Psychiatry. 2022 Apr 13:e220597. doi: 10.1001/jamapsychiatry.2022.0597. Online ahead of print.PMID: 35416928
COVID-19 vaccination and HIV-1 acquisition. Logunov DY, Livermore DM, Ornelles DA, Bayer W, Marques E, Czerkinsky C, Dolzhikova IV, Ertl HC. Lancet. 2022 Apr 9;399(10333):e34-e35. doi: 10.1016/S0140-6736(22)00332-4.PMID: 35397866
Editorial: Deciphering the Microbiome-Immunity-Cancer Axis. Chen X, Jin C, Facciabene A, Guo X, Zhang Y. Front Immunol. 2022 Apr 14;13:897811. doi: 10.3389/fimmu.2022.897811. eCollection 2022.PMID: 35493451
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy . Smith M, Dai A, Ghilardi G, Amelsberg KV, Devlin SM, Pajarillo R, Slingerland JB, Beghi S, Herrera PS, Giardina P, Clurman A, Dwomoh E, Armijo G, Gomes ALC, Littmann ER, Schluter J, Fontana E, Taur Y, Park JH, Palomba ML, Halton E, Ruiz J, Jain T, Pennisi M, Afuye AO, Perales MA, Freyer CW, Garfall A, Gier S, Nasta S, Landsburg D, Gerson J, Svoboda J, Cross J, Chong EA, Giralt S, Gill SI, Riviere I, Porter DL, Schuster SJ, Sadelain M, Frey N, Brentjens RJ, June CH, Pamer EG, Peled JU, Facciabene A, van den Brink MRM, Ruella M. Nat Med. 2022 Apr;28(4):713-723. doi: 10.1038/s41591-022-01702-9. Epub 2022 Mar 14.PMID: 35288695
Increased mTORC2 pathway activation in lymph nodes of iMCD-TAFRO . Phillips AD, Kakkis JJ, Tsao PY, Pierson SK, Fajgenbaum DC. J Cell Mol Med. 2022 Apr 30. doi: 10.1111/jcmm.17251. Online ahead of print.PMID: 35488725
The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease. Horna P, King RL, Jevremovic D, Fajgenbaum DC, Dispenzieri A. Haematologica. 2022 Apr 28. doi: 10.3324/haematol.2021.280370. Online ahead of print.PMID: 35484648
Bone marrow findings of idiopathic Multicentric Castleman disease: A histopathologic analysis and systematic literature review. Belyaeva E, Rubenstein A, Pierson SK, Dalldorf D, Frank D, Lim MS, Fajgenbaum DC. Hematol Oncol. 2022 Apr;40(2):191-201. doi: 10.1002/hon.2969. Epub 2022 Feb 18.PMID: 35104370
Guideline to Practice: Diagnosis and Management of Barrett's Esophagus: An Updated ACG Guideline. Shaheen NJ, Falk GW, Iyer PG, Souza RF, Wani S. Am J Gastroenterol. 2022 Apr 15. doi: 10.14309/ajg.0000000000001788. Online ahead of print.PMID: 35467555
Diagnosis and Management of Barrett's Esophagus: An Updated ACG Guideline. Shaheen NJ, Falk GW, Iyer PG, Souza RF, Yadlapati RH, Sauer BG, Wani S. Am J Gastroenterol. 2022 Apr 1;117(4):559-587. doi: 10.14309/ajg.0000000000001680.PMID: 35354777
Can FLIP guide therapy in idiopathic esophagogastric junction outflow obstruction? Beveridge CA, Triggs JR, Thanawala SU, Ahuja NK, Falk GW, Benitez AJ, Lynch KL. Dis Esophagus. 2022 Apr 19;35(4):doab077. doi: 10.1093/dote/doab077.PMID: 34864928
The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer. Ricarte-Filho JC, Halada S, O'Neill A, Casado-Medrano V, Laetsch TW, Franco AT, Bauer AJ. Cancer Genet. 2022 Apr;262-263:57-63. doi: 10.1016/j.cancergen.2022.01.002. Epub 2022 Jan 19.PMID: 35092884
Fusion Oncogenes Are Associated With Increased Metastatic Capacity and Persistent Disease in Pediatric Thyroid Cancers. Franco AT, Ricarte-Filho JC, Isaza A, Jones Z, Jain N, Mostoufi-Moab S, Surrey L, Laetsch TW, Li MM, DeHart JC, Reichenberger E, Taylor D, Kazahaya K, Adzick NS, Bauer AJ. .J Clin Oncol. 2022 Apr 1;40(10):1081-1090. doi: 10.1200/JCO.21.01861. Epub 2022 Jan 11.PMID: 35015563
Initial analysis of viral dynamics and circulating viral variants during the mRNA-1273 Phase 3 COVE trial . Pajon R, Paila YD, Girard B, Dixon G, Kacena K, Baden LR, El Sahly HM, Essink B, Mullane KM, Frank I, Denhan D, Kerwin E, Zhao X, Ding B, Deng W, Tomassini JE, Zhou H, Leav B, Schödel F; COVE Trial Consortium. Nat Med. 2022 Apr;28(4):823-830. doi: 10.1038/s41591-022-01679-5. Epub 2022 Feb 10.PMID: 35145311
Methotrexate promotes recovery of arthritis-induced alveolar bone loss and modifies the composition of the oral-gut microbiota. Almeida de Arruda JA, Corrêa JD, Singh Y, Oliveira SR, Machado CC, Schneider AH, Medeiros JD, Fernandes GR, Macari S, Barrioni BR, de Souza Santos M, Duffles LF, Imoto Nakaya HT, Fukada SY, Graves DT, Cunha FQ, Silva TA. Anaerobe. 2022 Apr 28:102577. doi: 10.1016/j.anaerobe.2022.102577. Online ahead of print.PMID: 35490916
Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes. Plenderleith LJ, Liu W, Li Y, Loy DE, Mollison E, Connell J, Ayouba A, Esteban A, Peeters M, Sanz CM, Morgan DB, Wolfe ND, Ulrich M, Sachse A, Calvignac-Spencer S, Leendertz FH, Shaw GM, Hahn BH, Sharp PM. Nat Commun. 2022 Apr 6;13(1):1868. doi: 10.1038/s41467-022-29306-4.PMID: 35387986
Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Li X, Wang H, Yu X, Saha G, Kalafati L, Ioannidis C, Mitroulis I, Netea MG, Chavakis T, Hajishengallis G. Cell. 2022 Apr 21:S0092-8674(22)00393-2. doi: 10.1016/j.cell.2022.03.043. Online ahead of print.PMID: 35483374
Transarterial Embolization Modulates the Immune Response within Target and Nontarget Hepatocellular Carcinomas in a Rat Model. Tischfield DJ, Gurevich A, Johnson O, Gatmaytan I, Nadolski GJ, Soulen MC, Kaplan DE, Furth E, Hunt SJ, Gade TPF. Radiology. 2022 Apr;303(1):215-225. doi: 10.1148/radiol.211028. Epub 2022 Jan 11.PMID: 35014906
MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection. Stelekati E, Cai Z, Manne S, Chen Z, Beltra JC, Buchness LA, Leng X, Ristin S, Nzingha K, Ekshyyan V, Niavi C, Abdel-Hakeem MS, Ali MA, Drury S, Lau CW, Gao Z, Ban Y, Zhou SK, Ansel KM, Kurachi M, Jordan MS, Villarino AV, Ngiow SF, Wherry EJ. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2106083119. doi: 10.1073/pnas.2106083119. Epub 2022 Apr 21.PMID: 35446623
Engineered cellular immunotherapies in cancer and beyond. Finck AV, Blanchard T, Roselle CP, Golinelli G, June CH. Nat Med. 2022 Apr;28(4):678-689. doi: 10.1038/s41591-022-01765-8. Epub 2022 Apr 19.PMID: 35440724
Next-Generation CAR T-cell Therapies. Young RM, Engel NW, Uslu U, Wellhausen N, June CH. Cancer Discov. 2022 Apr 12:OF1-OF14. doi: 10.1158/2159-8290.CD-21-1683. Online ahead of print.PMID: 35417527
VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development . Sung DC, Chen X, Chen M, Yang J, Schultz S, Babu A, Xu Y, Gao S, Stevenson Keller TC, Mericko P, Lee M, Yang Y, Scallan JP, Kahn ML. Elife. 2022 Apr 29;11:e77241. doi: 10.7554/eLife.77241. Online ahead of print.PMID: 35486098
The Association Between Proton Pump Inhibitor Exposure and Key Liver-Related Outcomes in Patients With Cirrhosis: A Veterans Affairs Cohort Study. Mahmud N, Serper M, Taddei TH, Kaplan DE. Gastroenterology. 2022 Apr 6:S0016-5085(22)00352-3. doi: 10.1053/j.gastro.2022.03.052. Online ahead of print.PMID: 35398042
Current challenges and opportunities in the care of patients with fibrodysplasia ossificans progressiva (FOP): an international, multi-stakeholder perspective. Pignolo RJ, Bedford-Gay C, Cali A, Davis M, Delai PLR, Gonzales K, Hixson C, Kent A, Newport H, Robert M, Scott C, Kaplan FS. Orphanet J Rare Dis. 2022 Apr 18;17(1):168. doi: 10.1186/s13023-022-02224-w.PMID: 35436894
Yield of upper gastrointestinal screening in colonic adenomatous polyposis of unknown etiology: a multicenter study . Farah F, Patel SG, Espinoza JM, Jensen N, Katona BW, Muller C, Kupfer SS, Weiss JM, Hinton A, Stanich PP. Endosc Int Open. 2022 Apr 14;10(4):E528-E533. doi: 10.1055/a-1784-0166. eCollection 2022 Apr.PMID: 35433207
Management of Relapsed Cutaneous T-Cell Lymphoma Following Allogeneic Hematopoietic Stem Cell Transplantation: Review with Representative Patient Case. Weiner DM, Lewis DJ, Spaccarelli NG, Clark RA, Nasta SD, Loren AW, Rook AH, Kim EJ. Dermatol Ther. 2022 Apr 27:e15538. doi: 10.1111/dth.15538. Online ahead of print.PMID: 35477952
Parapsoriasis-A Diagnosis with an Identity Crisis: A Narrative Review . Chairatchaneeboon M, Thanomkitti K, Kim EJ. Dermatol Ther (Heidelb). 2022 Apr 15. doi: 10.1007/s13555-022-00716-y. Online ahead of print.PMID: 35426607
The Women of FOCIS: Promoting Equality and Inclusiveness in a Professional Federation of Clinical Immunology Societies . Reed EF, Chong AS, Levings MK, Mutrie C, Laufer TM, Roncarolo MG, Sykes M. Front Immunol. 2022 Apr 4;13:816535. doi: 10.3389/fimmu.2022.816535. eCollection 2022.PMID: 35444663
2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease. Gorelik M, Chung SA, Ardalan K, Binstadt BA, Friedman K, Hayward K, Imundo LF, Lapidus SK, Kim S, Son MB, Sule S, Tremoulet AH, Van Mater H, Yildirim-Toruner C, Langford CA, Maz M, Abril A, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Merkel PA, Rhee RL, Seo P, Stone JH, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot M, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA. Arthritis Care Res(Hoboken). 2022 Apr;74(4):538-548. doi: 10.1002/acr.24838. Epub 2022 Mar 7.PMID: 35257507
Cytosolic Delivery of Small Protein Scaffolds Enables Efficient Inhibition of Ras and Myc. Chan A, Wang HH, Haley RM, Song C, Gonzalez-Martinez D, Bugaj L, Mitchell MJ, Tsourkas A. Mol Pharm. 2022 Apr 4;19(4):1104-1116. doi: 10.1021/acs.molpharmaceut.1c00798. Epub 2022 Feb 28.PMID: 35225618
Circulating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model. Habertheuer A, Ram C, Schmierer M, Chatterjee S, Hu R, Freas A, Zielinski P, Rogers W, Silvestro EM, McGrane M, Moore JS, Korutla L, Siddiqui S, Xin Y, Rizi R, Qin Tao J, Kreisel D, Naji A, Ochiya T, Vallabhajosyula P. Transplantation. 2022 Apr 1;106(4):754-766. doi: 10.1097/TP.0000000000003820.PMID: 33993180
Temporal Outcomes after Rituximab Therapy for Pemphigus Vulgaris. Tovanabutra N, Bax CE, Feng R, Kushner CJ, Payne AS. J Invest Dermatol. 2022 Apr;142(4):1058-1064.e7. doi: 10.1016/j.jid.2021.09.013. Epub 2021 Oct 26.PMID: 34710389
Salvage therapy with basiliximab and etanercept for severe steroid-refractory acute graft-versus-host disease. Freyer CW, Gier S, Carulli A, Gill SI, Hexner EO, Loren AW, Martin ME, Porter DL. Am J Hematol. 2022 Apr 12. doi: 10.1002/ajh.26568. Online ahead of print.PMID: 35413140
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy. Smith M, Dai A, Ghilardi G, Amelsberg KV, Devlin SM, Pajarillo R, Slingerland JB, Beghi S, Herrera PS, Giardina P, Clurman A, Dwomoh E, Armijo G, Gomes ALC, Littmann ER, Schluter J, Fontana E, Taur Y, Park JH, Palomba ML, Halton E, Ruiz J, Jain T, Pennisi M, Afuye AO, Perales MA, Freyer CW, Garfall A, Gier S, Nasta S, Landsburg D, Gerson J, Svoboda J, Cross J, Chong EA, Giralt S, Gill SI, Riviere I, Porter DL, Schuster SJ, Sadelain M, Frey N, Brentjens RJ, June CH, Pamer EG, Peled JU, Facciabene A, van den Brink MRM, Ruella M. Nat Med. 2022 Apr;28(4):713-723. doi: 10.1038/s41591-022-01702-9. Epub 2022 Mar 14.PMID: 35288695
Mitogen-Activated Protein Kinase Inhibitor Selumetinib Fails to Increase the Complete Response Rate of Radioactive Iodine Alone in High-Risk Differentiated Thyroid Cancer: Lessons From the Phase III ASTRA Study . Brose MS, Pryma DA, Newbold KL. J Clin Oncol. 2022 Apr 29:JCO2200556. doi: 10.1200/JCO.22.00556. Online ahead of print.PMID: 35486879
Comprehensive nutrient consumption estimation and metabolic profiling during ketogenic diet and relationship with myocardial glucose uptake on FDG-PET. Selvaraj S, Seidelmann SB, Soni M, Bhattaru A, Margulies KB, Shah SH, Dugyala S, Qian C, Pryma DA, Arany Z, Kelly DP, Chirinos JA, Bravo PE. Eur Heart J Cardiovasc Imaging. 2022 Apr 2:jeac031. doi: 10.1093/ehjci/jeac031. Online ahead of print.PMID: 35366303
Investigating the relationships between resilience, autism-related quantitative traits, and mental health outcomes among adults during the COVID-19 pandemic . Taylor SC, Smernoff ZL, Rajan M, Steeman S, Gehringer BN, Dow HC, Barzilay R, Rader DJ, Bucan M, Almasy L, Brodkin ES. J Psychiatr Res. 2022 Apr;148:250-257. doi: 10.1016/j.jpsychires.2022.01.046. Epub 2022 Jan 29.PMID: 35151216
Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure. Clarke SL, Tcheandjieu C, Hilliard AT, Lee KM, Lynch J, Chang KM, Miller D, Knowles JW, O'Donnell C, Tsao PS, Rader DJ, Wilson PW, Sun YV, Gaziano JM, Assimes TL; VA Million Veteran Program. Circ Genom Precis Med. 2022 Apr;15(2):e003501. doi: 10.1161/CIRCGEN.121.003501. Epub 2022 Feb 10.PMID: 35143253
Web of Science's Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor. Daugherty A, Hegele RA, Lu HS, Mackman N, Rader DJ, Weber C.Arterioscler Thromb Vasc Biol. 2022 Apr;42(4):367-371. doi: 10.1161/ATVBAHA.122.317426. Epub 2022 Feb 3.PMID: 35109675
Genetic obstacles to developing and tolerizing human B cells. Nguyen K, Alsaati N, Le Coz C, Romberg N. WIREs Mech Dis. 2022 Apr 5:e1554. doi: 10.1002/wsbm.1554. Online ahead of print.PMID: 35384409
Kikuchi-Fujimoto disease is mediated by an aberrant type I interferon response . Li EY, Xu J, Nelson ND, Teachey DT, Tan K, Romberg N, Behrens E, Pillai V. Mod Pathol. 2022 Apr;35(4):462-469. doi: 10.1038/s41379-021-00992-7. Epub 2021 Dec 24.PMID: 34952944
Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation. Shahin T, Mayr D, Shoeb MR, Kuehn HS, Hoeger B, Giuliani S, Gawriyski LM, Petronczki ÖY, Hadjadj J, Bal SK, Zoghi S, Haimel M, Jimenez Heredia R, Boutboul D, Triebwasser MP, Rialland-Battisti F, Costedoat Chalumeau N, Quartier P, Tangye SG, Fleisher TA, Rezaei N, Romberg N, Latour S, Varjosalo M, Halbritter F, Rieux-Laucat F, Castanon I, Rosenzweig SD, Boztug K. Blood Adv. 2022 Apr 12;6(7):2444-2451. doi: 10.1182/bloodadvances.2021006367.PMID: 34920454
Resistance to mogamulizumab is associated with loss of CCR4 in Cutaneous T-cell Lymphoma. Beygi S, Duran GE, Fernandez-Pol S, Rook AH, Kim YH, Khodadoust MS. Blood. 2022 Apr 18:blood.2021014468. doi: 10.1182/blood.2021014468. Online ahead of print.PMID: 35436328
Post-treatment gene scores support histologic and endoscopic response thresholds in eosinophilic esophagitis. Ruffner MA, Cotton CC, Dellon ES. Am J Gastroenterol. 2022 Apr 26. doi: 10.14309/ajg.0000000000001802. Online ahead of print.PMID: 35470295
Expression of Human Interleukin 8 in Mice Alters Their Natural Behaviors. Tian Z, Shofer FS, Sandroni AZ, Zhao L, Scanzello CR, Zhang Y. J Inflamm Res. 2022 Apr 13;15:2413-2424. doi: 10.2147/JIR.S355669. eCollection 2022.PMID: 35444450
Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict β-coronaviral infection and replication . Sarkar L, Oko L, Gupta S, Bubak AN, Das B, Gupta P, Safiriyu AA, Singhal C, Neogi U, Bloom D, Banerjee A, Mahalingam R, Cohrs RJ, Koval M, Shindler KS, Pal D, Nagel M, Sarma JD. Virology. 2022 Apr;569:13-28. doi: 10.1016/j.virol.2022.01.002. Epub 2022 Feb 15.PMID: 35219218
The impact of head and neck radiotherapy on salivary flow and quality of life: Results of the ORARAD study. Lin A, Helgeson ES, Treister NS, Schmidt BL, Patton LL, Elting LS, Lalla RV, Brennan MT, Sollecito TP. Oral Oncol. 2022 Apr;127:105783. doi: 10.1016/j.oraloncology.2022.105783. Epub 2022 Feb 26.PMID: 35231809
MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo. Bennett LF, Mumau MD, Li Y, Speck NA. Development. 2022 Apr 15;149(8):dev200025. doi: 10.1242/dev.200025. Epub 2022 Feb 11.PMID: 35043940
Nasopharyngeal airway dual-transcriptome of infants with severe bronchiolitis and risk of childhood asthma: A multicenter prospective study. Zhu Z, Camargo CA Jr, Raita Y, Freishtat RJ, Fujiogi M, Hahn A, Mansbach JM, Spergel JM, Pérez-Losada M, Hasegawa K. J Allergy Clin Immunol. 2022 Apr 25:S0091-6749(22)00556-5. doi: 10.1016/j.jaci.2022.04.017. Online ahead of print.PMID: 35483507
Disease burden and unmet need in eosinophilic esophagitis. Bredenoord AJ, Patel K, Schoepfer AM, Dellon ES, Chehade M, Aceves SS, Spergel JM, Shumel B, Deniz Y, Rowe PJ, Jacob-Nara JA. Am J Gastroenterol. 2022 Apr 13. doi: 10.14309/ajg.0000000000001777. Online ahead of print.PMID: 35417421
Esophageal remodeling in Eosinophilic Esophagitis: Relationships to luminal captured biomarkers of inflammation and periostin. Muir A, Ackerman SJ, Pan Z, Benitez A, Burger C, Spergel JM, Furuta GT, Rothman J, Wilkins BJ, Arnold M, Dolinsky L, Grozdanovic M, Menard-Katcher C. J Allergy Clin Immunol. 2022 Apr 8:S0091-6749(22)00444-4. doi: 10.1016/j.jaci.2022.03.022. Online ahead of print.PMID: 35405206
Novel questionnaires for assessing signs and symptoms of eosinophilic esophagitis in children. Kamat S, Yaworsky A, Guillemin I, Krohe M, Litcher-Kelly L, McLafferty M, Lamoureux RE, Lowe C, Chehade M, Spergel JM, Weinfurt K, Turner-Bowker DM .J Allergy Clin Immunol Pract. 2022 Apr 7:S2213-2198(22)00331-2. doi: 10.1016/j.jaip.2022.02.049. Online ahead of print.PMID: 35398552
Live imaging of the Cryptosporidium parvum life cycle reveals direct development of male and female gametes from type I meronts. English ED, Guérin A, Tandel J, Striepen B. PLoS Biol. 2022 Apr 18;20(4):e3001604. doi: 10.1371/journal.pbio.3001604. eCollection 2022 Apr.PMID: 35436284
Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia. Meyer LK, Delgado-Martin C, Sharp PP, Huang BJ, McMinn D, Vincent TL, Ryan T, Horton TM, Wood BL, Teachey DT, Taunton J, Kirk CJ, Hermiston ML. Br J Haematol. 2022 Apr 17. doi: 10.1111/bjh.18181. Online ahead of print.PMID: 35434798
JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia . Bodaar K, Yamagata N, Barthe A, Landrigan J, Chonghaile TN, Burns M, Stevenson KE, Devidas M, Loh ML, Hunger SP, Wood B, Silverman LB, Teachey DT, Meijerink JP, Letai A, Gutierrez A. Leukemia. 2022 Apr 11. doi: 10.1038/s41375-022-01558-5. Online ahead of print.PMID: 35411095
A minimal monitoring approach for the treatment of hepatitis C virus infection (ACTG A5360 [MINMON]): a phase 4, open-label, single-arm trial. Solomon SS, Wagner-Cardoso S, Smeaton L, Sowah LA, Wimbish C, Robbins G, Brates I, Scello C, Son A, Avihingsanon A, Linas B, Anthony D, Nunes EP, Kliemann DA, Supparatpinyo K, Kityo C, Tebas P, Bennet JA, Santana-Bagur J, Benson CA, Van Schalkwyk M, Cheinquer N, Naggie S, Wyles D, Sulkowski M. Lancet Gastroenterol Hepatol. 2022 Apr;7(4):307-317. doi: 10.1016/S2468-1253(21)00397-6. Epub 2022 Jan 10. PMID: 35026142
Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells . Cai T, Gouble A, Black KL, Skwarska A, Naqvi AS, Taylor D, Zhao M, Yuan Q, Sugita M, Zhang Q, Galetto R, Filipe S, Cavazos A, Han L, Kuruvilla V, Ma H, Weng C, Liu CG, Liu X, Konoplev S, Gu J, Tang G, Su X, Al-Atrash G, Ciurea S, Neelapu SS, Lane AA, Kantarjian H, Guzman ML, Pemmaraju N, Smith J, Thomas-Tikhonenko A, Konopleva M. Nat Commun. 2022 Apr 28;13(1):2228. doi: 10.1038/s41467-022-29669-8. PMID: 35484100
Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy . Gui T, Luo L, Chhay B, Zhong L, Wei Y, Yao L, Yu W, Li J, Nelson CL, Tsourkas A, Qin L, Cheng Z. Biomaterials. 2022 Apr;283:121437. doi: 10.1016/j.biomaterials.2022.121437. Epub 2022 Feb 23. PMID: 35247635
Molecular therapies and vaccines face the challenges of emerging infectious diseases . Patel A, Weiner D, Xiao W, Baker A, Sanders N. Mol Ther. 2022 Apr 15;30(5):1789-90. doi: 10.1016/j.ymthe.2022.04.003. Online ahead of print. PMID: 35429438
DRUMMER-Rapid detection of RNA modifications through comparative nanopore sequencing . Abebe JS, Price AM, Hayer KE, Mohr I, Weitzman MD, Wilson AC, Depledge DP. Bioinformatics. 2022 Apr 15:btac274. doi: 10.1093/bioinformatics/btac274. Online ahead of print. PMID: 35426900
Safety and Efficacy of Lenabasum, a Cannabinoid Receptor Type 2 Agonist, in Dermatomyositis Patients with Refractory Skin Disease A Randomized Clinical Trial. Werth VP, Hejazi E, Pena SM, Haber J, Zeidi M, Reddy N, Okawa J, Feng R, Bashir MM, Gebre K, Jadoo AS, Concha JSS, Dgetluck N, Constantine S, White B. J Invest Dermatol. 2022 Apr 28:S0022-202X(22)00295-0. doi: 10.1016/j.jid.2022.03.029. Online ahead of print. PMID: 35490744
Biological impact of iberdomide in patients with active systemic lupus erythematosus. Lipsky PE, Vollenhoven RV, Dörner T, Werth VP, Merrill JT, Furie R, Petronijevic M, Velasco Zamora B, Majdan M, Irazoque-Palazuelos F, Terbrueggen R, Delev N, Weiswasser M, Korish S, Stern M, Hersey S, Ye Y, Gaudy A, Liu Z, Gagnon R, Tang S, Schafer PH. Ann Rheum Dis. 2022 Apr 27:annrheumdis-2022-222212. doi: 10.1136/annrheumdis-2022-222212. Online ahead of print. PMID: 35477518
Preliminary definition of cutaneous flare in dermatomyositis: A retrospective review. Dan J, Afarideh M, Sprow G, Keyes E, Diaz D, Vazquez T, Kodali N, Werth VP. J Am Acad Dermatol. 2022 Apr 2:S0190-9622(22)00546-1. doi: 10.1016/j.jaad.2022.03.054. Online ahead of print. PMID: 35381299
Increased CD69+CCR7+ circulating activated T cells and STAT3 expression in cutaneous lupus erythematosus patients recalcitrant to antimalarials . Zeidi M, Chen KL, Patel J, Desai K, Kim HJ, Chakka S, Lim R, Werth VP. Lupus. 2022 Apr;31(4):472-481. doi: 10.1177/09612033221084093. Epub 2022 Mar 8. PMID: 35258358
Sclerotic skin disease development following COVID-19 vaccination . Sprow G, Dan J, Abbott J, Jiang A, Diaz D, Vazquez T, Kodali N, Werth VP. JAAD Case Rep. 2022 Apr;22:74-77. doi: 10.1016/j.jdcr.2022.02.008. Epub 2022 Feb 23. PMID: 35224171
MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection. Stelekati E, Cai Z, Manne S, Chen Z, Beltra JC, Buchness LA, Leng X, Ristin S, Nzingha K, Ekshyyan V, Niavi C, Abdel-Hakeem MS, Ali MA, Drury S, Lau CW, Gao Z, Ban Y, Zhou SK, Ansel KM, Kurachi M, Jordan MS, Villarino AV, Ngiow SF, Wherry EJ. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2106083119. doi: 10.1073/pnas.2106083119. Epub 2022 Apr 21. PMID: 35446623
Autophagy and pluripotency: self-eating your way to eternal youth. Xu Y, Yang X. Trends Cell Biol. 2022 Apr 27:S0962-8924(22)00089-7. doi: 10.1016/j.tcb.2022.04.001. Online ahead of print. PMID: 35490141

March 2022

Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19. Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Belman J, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ. Front Immunol. 2022 Mar 3;13:834988. doi: 10.3389/fimmu.2022.834988. eCollection 2022. PMID: 35309299
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers. Giles JR, Manne S, Freilich E, Oldridge DA, Baxter AE, George S, Chen Z, Huang H, Chilukuri L, Carberry M, Giles L, Weng NP, Young RM, June CH, Schuchter LM, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Huang AC, Shi J, Wherry EJ. Immunity. 2022 Mar 8;55(3):557-574.e7. doi: 10.1016/j.immuni.2022.02.004. PMID: 35263570
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Lederer K, Bettini E, Parvathaneni K, Painter MM, Agarwal D, Lundgreen KA, Weirick M, Muralidharan K, Castaño D, Goel RR, Xu X, Drapeau EM, Gouma S, Ort JT, Awofolaju M, Greenplate AR, Le Coz C, Romberg N, Trofe-Clark J, Malat G, Jones L, Rosen M, Weiskopf D, Sette A, Besharatian B, Kaminiski M, Hensley SE, Bates P, Wherry EJ, Naji A, Bhoj V, Locci M. Cell. 2022 Mar 17;185(6):1008-1024.e15. doi: 10.1016/j.cell.2022.01.027. Epub 2022 Feb 2. PMID: 35202565
Examining the Impact of Galectin-9 on Latent HIV Transcription. Adeniji OS, Giron LB, Abdel-Mohsen M. Methods Mol Biol. 2022;2442:463-474. doi: 10.1007/978-1-0716-2055-7_25. PMID: 35320541
Trends and Outcomes of Hypothermic Machine Perfusion Preservation of Kidney Allografts in Simultaneous Liver and Kidney Transplantation in the United States . Chang A, Schaubel DE, Chen M, Abt PL, Bittermann T. Transpl Int. 2022 Mar 14;35:10345. doi: 10.3389/ti.2022.10345. eCollection 2022. PMID: 35356400
Incidence of acute rejection and patient survival in combined heart-liver transplantation . Zhao K, Wang R, Kamoun M, Callans L, Bremner R, Rame E, McLean R, Cevasco M, Olthoff KM, Levine MH, Shaked A, Abt PL.Liver Transpl. 2022 Mar 5. doi: 10.1002/lt.26448. Online ahead of print.PMID: 35247292
Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine . Hook LM, Awasthi S, Cairns TM, Alameh MG, Fowler BT, Egan KP, Sung MMH, Weissman D, Cohen GH, Friedman HM. Viruses. 2022 Mar 5;14(3):540. doi: 10.3390/v14030540. PMID: 35336946
Significance of RUNX1 mutation in BCR-ABL1 positive acute myeloid leukemia - a diagnostic dilemma in a young woman with persistent bleeding . Ghosh S, Roth J, Babushok D, Lim M. Leuk Lymphoma. 2022 Mar 15:1-5. doi: 10.1080/10428194.2022.2047673. Online ahead of print. PMID: 35290157
Venetoclax in combination with hypomethylating agents or low dose cytarabine for relapsed and refractory acute myeloid leukemia . Graveno ME, Carulli A, Freyer CW, Mangan BL, Nietupski R, Loren AW, Frey NV, Porter DL, Gill SI, Hexner EO, Luger SM, Martin ME, McCurdy SR, Perl AE, Babushok DV, Pratz KW. Leuk Lymphoma. 2022 Mar 8:1-6. doi: 10.1080/10428194.2022.2042688. Online ahead of print. PMID: 35259056
Progressive retinal changes in pediatric multiple sclerosis . Longoni G, Brown RA, Oyefiade A, Iruthayanathan R, Wilbur C, Shams S, Noguera A, Grover SA, O'Mahony J, Chung L, Wan MJ, Mah JK, Costello F, Arnold DL, Marrie RA, Bar-Or A, Banwell B, Mabbott D, Reginald AY, Yeh EA. Mult Scler Relat Disord. 2022 Mar 23;61:103761. doi: 10.1016/j.msard.2022.103761. Online ahead of print. PMID: 35349885
Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases . Liang G, Zhu F, Mirza AI, Bar-Or A, Bernstein CN, Bonner C, Forbes JD, Graham M, Hart J, Knox NC, Marrie RA, O'Mahony J, Van Domselaar G, Yeh EA, Zhao Y, Banwell B, Waubant E, Tremlett H; Canadian Paediatric Demyelinating Disease Network. Mult Scler. 2022 Mar 16:13524585221079533. doi: 10.1177/13524585221079533. Online ahead of print. PMID: 35296164
Efficacy and safety of ofatumumab in recently diagnosed, treatment-naive patients with multiple sclerosis: Results from ASCLEPIOS I and II. Gärtner J, Hauser SL, Bar-Or A, Montalban X, Cohen JA, Cross AH, Deiva K, Ganjgahi H, Häring DA, Li B, Pingili R, Ramanathan K, Su W, Willi R, Kieseier B, Kappos L. Mult Scler. 2022 Mar 10:13524585221078825. doi: 10.1177/13524585221078825. Online ahead of print. PMID: 35266417
Effect of siponimod on magnetic resonance imaging measures of neurodegeneration and myelination in secondary progressive multiple sclerosis: Gray matter atrophy and magnetization transfer ratio analyses from the EXPAND phase 3 trial . Arnold DL, Piani-Meier D, Bar-Or A, Benedict RH, Cree BA, Giovannoni G, Gold R, Vermersch P, Arnould S, Dahlke F, Hach T, Ritter S, Karlsson G, Kappos L, Fox RJ; EXPAND Clinical Investigators. Mult Scler. 2022 Mar 9:13524585221076717. doi: 10.1177/13524585221076717. Online ahead of print. PMID: 35261318
Pathways to cures for multiple sclerosis: A research roadmap . Bebo BF Jr, Allegretta M, Landsman D, Zackowski KM, Brabazon F, Kostich WA, Coetzee T, Ng AV, Marrie RA, Monk KR, Bar-Or A, Whitacre CC. Mult Scler. 2022 Mar;28(3):331-345. doi: 10.1177/13524585221075990. PMID: 35236198
Accumulation of meningeal lymphocytes correlates with white matter lesion activity in progressive multiple sclerosis . Ahmed SM, Fransen NL, Touil H, Michailidou I, Huitinga I, Gommerman JL, Bar-Or A, Ramaglia V. JCI Insight. 2022 Mar 8;7(5):e151683. doi: 10.1172/jci.insight.151683. PMID: 35104246
Treatment of a genetic brain disease by CNS-wide microglia replacement . Shibuya Y, Kumar KK, Mader MM, Yoo Y, Ayala LA, Zhou M, Mohr MA, Neumayer G, Kumar I, Yamamoto R, Marcoux P, Liou B, Bennett FC, Nakauchi H, Sun Y, Chen X, Heppner FL, Wyss-Coray T, Südhof TC, Wernig M. Sci Transl Med. 2022 Mar 16;14(636):eabl9945. doi: 10.1126/scitranslmed.abl9945. Epub 2022 Mar 16. PMID: 35294256
Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection . Silverstein NJ, Wang Y, Manickas-Hill Z, Carbone C, Dauphin A, Boribong BP, Loiselle M, Davis J, Leonard MM, Kuri-Cervantes L; MGH COVID-19 Collection & Processing Team, Meyer NJ, Betts MR, Li JZ, Walker BD, Yu XG, Yonker LM, Luban J. Elife. 2022 Mar 11;11:e74681. doi: 10.7554/eLife.74681. PMID: 35275061
Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression . Wang L, Warzecha CC, Kistner A, Chichester JA, Bell P, Buza EL, He Z, Pampena MB, Couthouis J, Sethi S, McKeever K, Betts MR, Kakkis E, Wilson JM, Wadsworth S, Sullivan BA. Mol Ther Methods Clin Dev. 2022 Jan 19;24:292-305. doi: 10.1016/j.omtm.2022.01.007. eCollection 2022 Mar 10. PMID: 35211641
Variables affecting outcomes after allogeneic hematopoietic stem cell transplant for cerebral adrenoleukodystrophy . Chiesa R, Boelens JJ, Duncan CN, Kühl JS, Sevin C, Kapoor N, Prasad VK, Lindemans CA, Jones SA, Amartino HM, Algeri M, Bunin N, Diaz-de-Heredia C, Loes DJ, Shamir E, Timm A, McNeil E, Dietz AC, Orchard PJ. Blood Adv. 2022 Mar 8;6(5):1512-1524. doi: 10.1182/bloodadvances.2021005294. PMID: 34781360
Dual Affinity to RBCs and Target Cells (DART) Enhances Both Organ- and Cell Type-Targeting of Intravascular Nanocarriers . Ferguson LT, Hood ED, Shuvaeva T, Shuvaev VV, Basil MC, Wang Z, Nong J, Ma X, Wu J, Myerson JW, Marcos-Contreras OA, Katzen J, Carl JM, Morrisey EE, Cantu E, Villa CH, Mitragotri S, Muzykantov VR, Brenner JS. ACS Nano. 2022 Mar 22;16(3):4666-4683. doi: 10.1021/acsnano.1c11374. Epub 2022 Mar 10. PMID: 35266686
On the Twentieth Anniversary of Dendritic Cell Vaccines - Riding the Next Wave . Linette GP, Carreno BM. Cancer Res. 2022 Mar 15;82(6):966-968. doi: 10.1158/0008-5472.CAN-21-4440. PMID: 35288731
Impact of diagnostic genetics on remission MRD and transplantation outcomes in older AML patients. Murdock HM, Kim HT, Denlinger N, Vachhani P, Hambley BC, Manning BS, Gier S, Cho C, Tsai HK, McCurdy SR, Ho VT, Koreth J, Soiffer RJ, Ritz J, Carroll MP, Vasu S, Perales MA, Wang ES, Gondek LP, Devine SM, Alyea EP, Lindsley RC, Gibson CJ. Blood. 2022 Mar 14:blood.2021014520. doi: 10.1182/blood.2021014520. Online ahead of print. PMID: 35286378
BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes . Schaefer EJ, Wang HC, Karp HQ, Meyer CA, Cejas P, Gearhart MD, Adelman ER, Fares I, Apffel A, Lim K, Xie Y, Gibson CJ, Schenone M, Murdock HM, Wang ES, Gondek LP, Carroll MP, Vedula RS, Winer ES, Garcia JS, Stone RM, Luskin MR, Carr SA, Long HW, Bardwell VJ, Figueroa ME, Lindsley RC. Blood Cancer Discov. 2022 Mar 1;3(2):116-135. doi: 10.1158/2643-3230.BCD-21-0115. PMID: 35015684
Early Plasma Nuclear DNA, Mitochondrial DNA, and Nucleosome Concentrations Are Associated With Acute Kidney Injury in Critically Ill Trauma Patients . Faust HE, Oniyide O, Wang Y, Forker CM, Dunn T, Yang W, Lanken PN, Sims CA, Yehya N, Christie JD, Meyer NJ, Reilly JP, Mangalmurti NS, Shashaty MGS. Crit Care Explor. 2022 Mar 28;4(4):e0663. doi: 10.1097/CCE.0000000000000663. eCollection 2022 Apr. PMID: 35372847
SARS-CoV-2 vaccination and ITP in patients with de novo or preexisting ITP. Lee EJ, Beltrami-Moreira M, Al-Samkari H, Cuker A, DiRaimo J, Gernsheimer T, Kruse A, Kessler C, Kruse C, Leavitt AD, Lee AI, Liebman HA, Newland AC, Ray AE, Tarantino MD, Thachil J, Kuter DJ, Cines DB, Bussel JB. Blood. 2022 Mar 10;139(10):1564-1574. doi: 10.1182/blood.2021013411. PMID: 34587251
Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine. Hook LM, Awasthi S, Cairns TM, Alameh MG, Fowler BT, Egan KP, Sung MMH, Weissman D, Cohen GH, Friedman HM. Viruses. 2022 Mar 5;14(3):540. doi: 10.3390/v14030540. PMID: 35336946
A Summary of the Sixth International Workshop on Microbiome in HIV Pathogenesis, Prevention, and Treatment . Sherrill-Mix S, Yang M, Aldrovandi GM, Brenchley JM, Bushman FD, Collman RG, Dandekar S, Klatt NR, Lagenaur LA, Landay AL, Paredes R, Tachedjian G, Turpin JA, Serrano-Villar S, Lozupone CA, Ghosh M. AIDS Res Hum Retroviruses. 2022 Mar;38(3):173-180. doi: 10.1089/AID.2021.0173. Epub 2022 Jan 25. PMID: 34969255
The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury . Siripanthong B, Asatryan B, Hanff TC, Chatha SR, Khanji MY, Ricci F, Muser D, Ferrari VA, Nazarian S, Santangeli P, Deo R, Cooper LT Jr, Mohiddin SA, Chahal CAA. JACC Basic Transl Sci. 2022 Mar;7(3):294-308. doi: 10.1016/j.jacbts.2021.10.011. Epub 2022 Feb 9. PMID: 35165665
Risk Prediction Models for Atherosclerotic Cardiovascular Disease in Patients with Chronic Kidney Disease: The CRIC Study . Bundy JD, Rahman M, Matsushita K, Jaeger BC, Cohen JB, Chen J, Deo R, Dobre MA, Feldman HI, Flack J, Kallem RR, Lash JP, Seliger S, Shafi T, Weiner SJ, Wolf M, Yang W, Allen NB, Bansal N, He J; CRIC Study Investigators. J Am Soc Nephrol. 2022 Mar;33(3):601-611. doi: 10.1681/ASN.2021060747. Epub 2022 Feb 10. PMID: 35145041
Suppressing or Enhancing Macrophage Engulfment through the Use of CD47 and Related Peptides . Jalil AR, Tobin MP, Discher DE. Bioconjug Chem. 2022 Mar 22. doi: 10.1021/acs.bioconjchem.2c00019. Online ahead of print. PMID: 35316023
Human CD47-Derived Cyclic Peptides Enhance Engulfment of mAb-Targeted Melanoma by Primary Macrophages . Jalil AR, Andrechak JC, Hayes BH, Chenoweth DM, Discher DE. Bioconjug Chem. 2022 Mar 14. doi: 10.1021/acs.bioconjchem.2c00020. Online ahead of print. PMID: 35285229
A One Medicine Mission for an Effective Rabies Therapy . Knobel DL, Jackson AC, Bingham J, Ertl HCJ, Gibson AD, Hughes D, Joubert K, Mani RS, Mohr BJ, Moore SM, Rivett-Carnac H, Tordo N, Yeates JW, Zambelli AB, Rupprecht CE. Front Vet Sci. 2022 Mar 16;9:867382. doi: 10.3389/fvets.2022.867382. eCollection 2022. PMID: 35372555
Immunological Biomarker Discovery in Cure Regimens for Chronic Hepatitis B Virus Infection . Gehring AJ, Mendez P, Richter K, Ertl H, Donaldson EF, Mishra P, Maini M, Boonstra A, Lauer G, de Creus A, Whitaker K, Martinez SF, Weber J, Gainor E, Miller V. J Hepatol. 2022 Mar 5:S0168-8278(22)00127-1. doi: 10.1016/j.jhep.2022.02.020. Online ahead of print. PMID: 35259469
The effect of rapamycin and ibrutinib on antibody responses to adeno-associated virus vector-mediated gene transfer . Xiang Z, Kuranda K, Quinn W, Chekaoui A, Ambrose R, Hasanpourghadi M, Novikov M, Newman D, Cole C, Zhou X, Mingozzi F, Ertl HCJ. Hum Gene Ther. 2022 Mar 1. doi: 10.1089/hum.2021.258. Online ahead of print. PMID: 35229644
A prospective, multicenter study of bortezomib, cyclophosphamide, and dexamethasone in relapsed/refractory iMCD . Zhang L, Zhang MY, Cao XX, Zhou DB, Fajgenbaum DC, Dong YJ, Li J. Leuk Lymphoma. 2022 Mar;63(3):618-626. doi: 10.1080/10428194.2021.1999437. Epub 2022 Jan 31. PMID: 35100929
Rio de Janeiro Global Consensus on Landmarks, Definitions and Classifications in Barrett's Esophagus: World Endoscopy Organization Delphi Study . Emura F, Chandrasekar VT, Hassan C, Armstrong D, Messmann H, Arantes V, Araya R, Barrera-Leon O, Bergman JJGHM, Bandhari P, Bourke MJ, Cerisoli C, Wai-Yan Chiu P, Desai M, Dinis-Ribeiro M, Falk GW, Fujishiro M, Gaddam S, Goda K, Gross S, Haidry R, Ho L, Iyer P, Kashin S, Kothari S, Lee YY, Matsuda K, Neuhaus H, Oyama T, Ragunath K, Repici A, Shaheen N, Singh R, Sobrino-Cossio S, Wang KK, Waxman I, Sharma P. Gastroenterology. 2022 Mar 23:S0016-5085(22)00284-0. doi: 10.1053/j.gastro.2022.03.022. Online ahead of print. PMID: 35339464
Prospective Endoscopic Activity Assessment for Eosinophilic Gastritis in a Multisite Cohort . Hirano I, Collins MH, King E, Sun Q, Chehade M, Abonia JP, Bonis PA, Capocelli KE, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Leung J, Katzka D, Menard-Katcher P, Khoury P, Klion A, Mukkada VA, Peterson K, Shoda T, Rudman-Spergel AK, Spergel JA, Yang GY, Rothenberg ME, Aceves SS, Furuta GT; CEGIR investigators. Am J Gastroenterol. 2022 Mar 1;117(3):413-423. doi: 10.14309/ajg.0000000000001625. PMID: 35080202
Analysis of Routine Computed Tomographic Scans With Radiomics and Machine Learning: One Step Closer to Clinical Practice . Farwell MD, Mankoff DA. JAMA Oncol. 2022 Mar 1;8(3):393-394. doi: 10.1001/jamaoncol.2021.6768. PMID: 35050318
NTRK-fusions in pediatric thyroid tumors: Current state and future perspectives . Casado-Medrano V, O'Neill A, Halada S, Laetsch TW, Bauer AJ, Franco AT. Cancer Genet. 2022 Mar 6;264-265:23-28. doi: 10.1016/j.cancergen.2022.02.009. Online ahead of print. PMID: 35290879
WWOX-Mediated Degradation of AMOTp130 Negatively Affects Egress of Filovirus VP40 Virus-Like Particles . Liang J, Ruthel G, Freedman BD, Harty RN. J Virol. 2022 Mar 23;96(6):e0202621. doi: 10.1128/jvi.02026-21. Epub 2022 Feb 2. PMID: 35107375
Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity . Bais S, Norwillo A, Ruthel G, Herbert DR, Freedman BD, Greenberg RM. Biochimie. 2022 Mar;194:108-117. doi: 10.1016/j.biochi.2021.12.018. Epub 2022 Jan 3. PMID: 34990770
Plasma Genotyping at the Time of Diagnostic Tissue Biopsy Decreases Time-to-Treatment in Patients With Advanced NSCLC-Results From a Prospective Pilot Study . Thompson JC, Aggarwal C, Wong J, Nimgaonkar V, Hwang WT, Andronov M, Dibardino DM, Hutchinson CT, Ma KC, Lanfranco A, Moon E, Haas AR, Singh AP, Ciunci CA, Marmarelis M, D'Avella C, Cohen JV, Bauml JM, Cohen RB, Langer CJ, Vachani A, Carpenter EL. JTO Clin Res Rep. 2022 Mar 8;3(4):100301. doi: 10.1016/j.jtocrr.2022.100301. eCollection 2022 Apr. PMID: 35392653
Detection of the HIV-1 Accessory Proteins Nef and Vpu by Flow Cytometry Represents a New Tool to Study Their Functional Interplay within a Single Infected CD4⁺ T Cell . Prévost J, Richard J, Gasser R, Medjahed H, Kirchhoff F, Hahn BH, Kappes JC, Ochsenbauer C, Duerr R, Finzi A. J Virol. 2022 Mar 23;96(6):e0192921. doi: 10.1128/jvi.01929-21. Epub 2022 Jan 26. PMID: 35080425
Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation . Failer T, Amponsah-Offeh M, Neuwirth A, Kourtzelis I, Subramanian P, Mirtschink P, Peitzsch M, Matschke K, Tugtekin SM, Kajikawa T, Li X, Steglich A, Gembardt F, Wegner AC, Hugo C, Hajishengallis G, Chavakis T, Deussen A, Todorov V, Kopaliani I. J Clin Invest. 2022 Mar 15;132(6):e126155. doi: 10.1172/JCI126155. PMID: 35133978
Supporting Careers of Women in Clinical Immunology: From Conceptualization to Implementation . Dimitriades VR, Freeman AF, Henrickson SE, Abraham RS. Front Pediatr. 2022 Mar 29;10:864734. doi: 10.3389/fped.2022.864734. eCollection 2022. PMID: 35425731
Too much and not enough: tuning human primary T cell cytokine signaling networks. Henrickson SE. Sci Immunol. 2022 Mar 4;7(69):eabo7677. doi: 10.1126/sciimmunol.abo7677. Epub 2022 Mar 4. PMID: 35245087
Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues. Feng Z, He X, Zhang X, Wu Y, Xing B, Knowles A, Shan Q, Miller S, Hojnacki T, Ma J, Katona BW, Gade TPF, Schrader J, Metz DC, June CH, Hua X. Nat Cancer. 2022 Mar 21. doi: 10.1038/s43018-022-00344-7. Online ahead of print. PMID: 35314826
2-Aminothiophene derivatives as a new class of positive allosteric modulators of glucagon-like peptide 1 receptor . Redij T, McKee JA, Do P, Campbell JA, Ma J, Li Z, Miller N, Srikanlaya C, Zhang D, Hua X, Li Z. Chem Biol Drug Des. 2022 Mar 21. doi: 10.1111/cbdd.14039. Online ahead of print. PMID: 35313084
Anti-CD19 CAR T Cells in Combination with Ibrutinib for the Treatment of Chronic Lymphocytic Leukemia . Gill SI, Frey NV, Hexner E, Metzger S, O'Brien M, Hwang WT, Brogdon JL, Davis MM, Fraietta JA, Gaymon A, Gladney WL, Lacey SF, Lamontagne A, Mato AR, Maus MV, Melenhorst JJ, Pequignot E, Ruella M, Shestov MA, Byrd JC, Schuster SJ, Siegel DL, Levine BL, June CH, Porter DL. Blood Adv. 2022 Mar 29:bloodadvances.2022007317. doi: 10.1182/bloodadvances.2022007317. Online ahead of print. PMID: 35349631
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers . Giles JR, Manne S, Freilich E, Oldridge DA, Baxter AE, George S, Chen Z, Huang H, Chilukuri L, Carberry M, Giles L, Weng NP, Young RM, June CH, Schuchter LM, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Huang AC, Shi J, Wherry EJ. Immunity. 2022 Mar 8;55(3):557-574.e7. doi: 10.1016/j.immuni.2022.02.004. PMID: 35263570
Developmental venous anomalies are a genetic primer for cerebral cavernous malformations. Snellings DA, Girard R, Lightle R, Srinath A, Romanos S, Li Y, Chen C, Ren AA, Kahn ML, Awad IA, Marchuk DA. Nat Cardiovasc Res. 2022 Mar;1:246-252. doi: 10.1038/s44161-022-00035-7. Epub 2022 Mar 14. PMID: 35355835
Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice . Summers BD, Kim K, Clement CC, Khan Z, Thangaswamy S, McCright J, Maisel K, Zamora S, Quintero S, Racanelli AC, Redmond D, D'Armiento J, Yang J, Kuang A, Monticelli L, Kahn ML, Choi AMK, Santambrogio L, Reed HO. Sci Rep. 2022 Mar 23;12(1):5012. doi: 10.1038/s41598-022-08617-y. PMID: 35322079
Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis. Yang Y, Mumau M, Tober J, Zhu Q, Bennett L, Hong C, Sung DC, Keller TCS, Uzun Y, Gao P, Shewale S, Chen M, Yang J, Chen X, Thomas SA, Tan K, Speck NA, Kahn ML. Blood. 2022 Mar 4:blood.2021013934. doi: 10.1182/blood.2021013934. Online ahead of print. PMID: 35245372
HLA antigens to epitopes: Meeting the challenge . Norin AJ, Gebel HM, Kamoun M. Hum Immunol. 2022 Mar;83(3):270-271. doi: 10.1016/j.humimm.2022.01.015. Epub 2022 Feb 8. PMID: 35148924
Accurate long-term prediction of death for patients with cirrhosis . Goldberg D, Mantero A, Kaplan D, Delgado C, John B, Nuchovich N, Emanuel E, Reese PP. Hepatology. 2022 Mar 12. doi: 10.1002/hep.32457. Online ahead of print. PMID: 35278226
Plasma-Soluble Biomarkers for Fibrodysplasia Ossificans Progressiva (FOP) Reflect Acute and Chronic Inflammatory States. Pignolo RJ, McCarrick-Walmsley R, Wang H, Qiu S, Hunter J, Barr S, He K, Zhang H, Kaplan FS. J Bone Miner Res. 2022 Mar;37(3):475-483. doi: 10.1002/jbmr.4492. Epub 2022 Jan 24. PMID: 34954853
Correction to: The PROVe Study: US Real-World Experience with Chlormethine/Mechlorethamine Gel in Combination with Other Therapies for Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma . Kim EJ, Guitart J, Querfeld C, Girardi M, Musiek A, Akilov OE, Angello JT, Bailey WL, Geskin LJ. Am J Clin Dermatol. 2022 Mar 15. doi: 10.1007/s40257-022-00676-1. Online ahead of print. PMID: 35292936
Usage and safety of topical tacrolimus in patients with mycosis fungoides . Weiner DM, Clark AK, Bhansali RS, Pappas-Taffer L, Barta SK, Villasenor-Park J, Haun PL, Vittorio CC, Rook AH, Kim EJ, Samimi SS. Clin Exp Dermatol. 2022 Mar 4. doi: 10.1111/ced.15162. Online ahead of print. PMID: 35245947
The Base-Editing Enzyme APOBEC3A Catalyzes Cytosine Deamination in RNA with Low Proficiency and High Selectivity . Barka A, Berríos KN, Bailer P, Schutsky EK, Wang T, Kohli RM. ACS Chem Biol. 2022 Mar 18;17(3):629-636. doi: 10.1021/acschembio.1c00919. Epub 2022 Mar 9. PMID: 35262324
Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma . Wu MJ, Shi L, Dubrot J, Merritt J, Vijay V, Wei TY, Kessler E, Olander KE, Adil R, Pankaj A, Tummala KS, Weeresekara V, Zhen Y, Wu Q, Luo M, Shen W, García-Beccaria M, Fernández-Vaquero M, Hudson C, Ronseaux S, Sun Y, Saad-Berreta R, Jenkins RW, Wang T, Heikenwälder M, Ferrone CR, Goyal L, Nicolay B, Deshpande V, Kohli RM, Zheng H, Manguso RT, Bardeesy N. Cancer Discov. 2022 Mar 1;12(3):812-835. doi: 10.1158/2159-8290.CD-21-1077. PMID: 34848557
Antibiotics and ECMO in the Adult Population-Persistent Challenges and Practical Guides. Gomez F, Veita J, Laudanski K. Antibiotics (Basel). 2022 Mar 4;11(3):338. doi: 10.3390/antibiotics11030338. PMID: 35326801
HiCuT: An efficient and low input method to identify protein-directed chromatin interactions . Sati S, Jones P, Kim HS, Zhou LA, Rapp-Reyes E, Leung TH. PLoS Genet. 2022 Mar 23;18(3):e1010121. doi: 10.1371/journal.pgen.1010121. eCollection 2022 Mar. PMID: 35320278
Neutrophilic Dermatoses: a Clinical Update . Weiss EH, Ko CJ, Leung TH, Micheletti RG, Mostaghimi A, Ramachandran SM, Rosenbach M, Nelson CA. Curr Dermatol Rep. 2022 Mar 16:1-14. doi: 10.1007/s13671-022-00355-8. Online ahead of print. PMID: 35310367
The Use and Duration of Preintubation Respiratory Support Is Associated With Increased Mortality in Immunocompromised Children With Acute Respiratory Failure . Lindell RB, Fitzgerald JC, Rowan CM, Flori HR, Di Nardo M, Napolitano N, Traynor DM, Lenz KB, Emeriaud G, Jeyapalan A, Nishisaki A; National Emergency Airway Registry for Children (NEAR4KIDS) and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Crit Care Med. 2022 Mar 14. doi: 10.1097/CCM.0000000000005535. Online ahead of print. PMID: 35275593
BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma . Mehnert JM, Mitchell TC, Huang AC, Aleman TS, Kim BJ, Schuchter LM, Linette GP, Karakousis GC, Mitnick S, Giles L, Carberry M, Frey N, Kossenkov A, Groisberg R, Hernandez-Aya LF, Ansstas G, Silk AW, Chandra S, Sosman JA, Gimotty PA, Mick R, Amaravadi RK. Clin Cancer Res. 2022 Mar 15;28(6):1098-1106. doi: 10.1158/1078-0432.CCR-21-3382. PMID: 35022320
No increase in inflammation in late-life major depression screened to exclude physical illness . Luning Prak ET, Brooks T, Makhoul W, Beer JC, Zhao L, Girelli T, Skarke C, Sheline YI. Transl Psychiatry. 2022 Mar 24;12(1):118. doi: 10.1038/s41398-022-01883-4. PMID: 35332134
Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies . Zheng S, Gillespie E, Naqvi AS, Hayer KE, Ang Z, Torres-Diz M, Quesnel-Vallières M, Hottman DA, Bagashev A, Chukinas J, Schmidt C, Asnani M, Shraim R, Taylor DM, Rheingold SR, O'Brien MM, Singh N, Lynch KW, Ruella M, Barash Y, Tasian SK, Thomas-Tikhonenko A. Blood Cancer Discov. 2022 Mar 1;3(2):103-115. doi: 10.1158/2643-3230.BCD-21-0087. PMID: 35015683
State-dependent olfactory processing in freely behaving mice . Schreck MR, Zhuang L, Janke E, Moberly AH, Bhattarai JP, Gottfried JA, Wesson DW, Ma M. Cell Rep. 2022 Mar 1;38(9):110450. doi: 10.1016/j.celrep.2022.110450. PMID: 35235805
Glutamate in primary afferents is required for itch transmission . Cui L, Guo J, Cranfill SL, Gautam M, Bhattarai J, Olson W, Beattie K, Challis RC, Wu Q, Song X, Raabe T, Gradinaru V, Ma M, Liu Q, Luo W. Neuron. 2022 Mar 2;110(5):809-823.e5. doi: 10.1016/j.neuron.2021.12.007. Epub 2022 Jan 4. PMID: 34986325
Trefoil Factor Family: A Troika for Lung Repair and Regeneration. Rossi HL, Ortiz-Carpena JF, Tucker D, Vaughan AE, Mangalmurti NS, Cohen NA, Herbert DR. Am J Respir Cell Mol Biol. 2022 Mar;66(3):252-259. doi: 10.1165/rcmb.2021-0373TR. PMID: 34784491
Do CARs finally hit the CLL road? Kater AP, Melenhorst JJ. Blood. 2022 Mar 24;139(12):1775-1776. doi: 10.1182/blood.2021014492. PMID: 35323881
STAT3 Role in T-Cell Memory Formation . Kaminskiy Y, Melenhorst JJ. Int J Mol Sci. 2022 Mar 7;23(5):2878. doi: 10.3390/ijms23052878. PMID: 35270020
Response to: Correspondence on '2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for granulomatosis with polyangiitis' by Joanna C Robson et al and '2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for microscopic polyangiitis' by Ravi Suppiah et al. Grayson PC, Robson JC, Suppiah R, Ponte C, Watts RA, Luqmani RA, Merkel PA. Ann Rheum Dis. 2022 Mar 22:annrheumdis-2022-222362. doi: 10.1136/annrheumdis-2022-222362. Online ahead of print. PMID: 35318216
Psychometric properties of outcome measurement instruments for ANCA-associated vasculitis: a systematic literature review . Berti A, Boleto G, Merkel PA, Tómasson G, Monti S, Quinn KA, Hassett LC, Carmona L, Ramiro S; OMERACT Vasculitis Working Group. Rheumatology (Oxford). 2022 Mar 16:keac175. doi: 10.1093/rheumatology/keac175. Online ahead of print. PMID: 35293985
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis. Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group. Ann Rheum Dis. 2022 Mar;81(3):309-314. doi: 10.1136/annrheumdis-2021-221794. Epub 2022 Feb 2. PMID: 35110334
Pulmonary and Critical Care Considerations for E-Cigarette, or Vaping, Product Use-Associated Lung Injury . Hayes D Jr, Board A, Calfee C, Ellington S, Pollack LA, Kathuria H, Eakin MN, Weissman DN, Callahan SJ, Esper AM, Crotty Alexander LE, Sharma NS, Meyer NJ, Smith LS, Novosad S, Evans ME, Goodman AB, Click ES, Robinson RT, Ewart G, Twentyman E. Chest. 2022 Mar 5:S0012-3692(22)00406-8. doi: 10.1016/j.chest.2022.02.039. Online ahead of print. PMID: 35257738
ONP-302 Nanoparticles Inhibit Tumor Growth By Altering Tumor-Associated Macrophages And Cancer-Associated Fibroblasts . Donthireddy L, Vonteddu P, Murthy T, Kwak T, Eraslan RN, Podojil JR, Elhofy A, Boyne MT 2nd, Puisis JJ, Veglia F, Singh SS, Dotiwala F, Montaner LJ, Gabrilovich DI. J Cancer. 2022 Mar 28;13(6):1933-1944. doi: 10.7150/jca.69338. eCollection 2022. PMID: 35399717
"We are looking at the future right now": community acceptability of a home-based viral load test device in the context of HIV cure-related research with analytical treatment interruptions in the United States. Dubé K, Kanazawa J, Roebuck C, Johnson S, Carter WB, Dee L, Peterson B, Lynn KM, Lalley-Chareczko L, Hiserodt E, Kim S, Rosenbloom D, Evans BR, Anderson M, Hazuda DJ, Shipley L, Bateman K, Howell BJ, Mounzer K, Tebas P, Montaner LJ. HIV Res Clin Pract. 2022 Mar 29:1-16. Online ahead of print. PMID: 35348047
Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones . Collora JA, Liu R, Pinto-Santini D, Ravindra N, Ganoza C, Lama JR, Alfaro R, Chiarella J, Spudich S, Mounzer K, Tebas P, Montaner LJ, van Dijk D, Duerr A, Ho YC. Immunity. 2022 Mar 17:S1074-7613(22)00127-3. doi: 10.1016/j.immuni.2022.03.004. Online ahead of print. PMID: 35320704
Reproductive Technology Considerations in Uterus Transplant . Walter JR, O'Neill KE. Clin Obstet Gynecol. 2022 Mar 1;65(1):68-75. doi: 10.1097/GRF.0000000000000684. PMID: 35045027
mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice . Mu Z, Wiehe K, Saunders KO, Henderson R, Cain DW, Parks R, Martik D, Mansouri K, Edwards RJ, Newman A, Lu X, Xia SM, Eaton A, Bonsignori M, Montefiori D, Han Q, Venkatayogi S, Evangelous T, Wang Y, Rountree W, Korber B, Wagh K, Tam Y, Barbosa C, Alam SM, Williams WB, Tian M, Alt FW, Pardi N, Weissman D, Haynes BF. Cell Rep. 2022 Mar 15;38(11):110514. doi: 10.1016/j.celrep.2022.110514. PMID: 35294883
Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways . Ellebrecht CT, Maseda D, Payne AS. J Invest Dermatol. 2022 Mar;142(3 Pt B):907-914. doi: 10.1016/j.jid.2021.04.040. Epub 2021 Oct 29. PMID: 34756581
Preliminary Evaluation of ⁶⁸Ga-P16-093, a PET Radiotracer Targeting Prostate-Specific Membrane Antigen in Prostate Cancer . Lee H, Scheuermann JS, Young AJ, Doot RK, Daube-Witherspoon ME, Schubert EK, Fillare MA, Alexoff D, Karp JS, Kung HF, Pryma DA. Mol Imaging Biol. 2022 Mar 29. doi: 10.1007/s11307-022-01720-6. Online ahead of print. PMID: 35349040
Associations of abdominal and cardiovascular adipose tissue depots with HDL metrics in midlife women: The SWAN Study . Nasr A, Matthews K, Janssen I, Brooks MM, Barinas-Mitchell E, Orchard TJ, Billheimer J, Wang NC, McConnell D, Rader DJ, El Khoudary SR. J Clin Endocrinol Metab. 2022 Mar 17:dgac148. doi: 10.1210/clinem/dgac148. Online ahead of print. PMID: 35298649
Dietary Vitamin E intake is associated with a reduced risk of developing digestive diseases and NAFLD . Scorletti E, Creasy KT, Vujkovic M, Vell M, Zandvakili I, Rader DJ, Schneider KM, Schneider CV. Am J Gastroenterol. 2022 Mar 14. doi: 10.14309/ajg.0000000000001726. Online ahead of print. PMID: 35288522
The relationship between lipoproteins and insulin sensitivity in youth with obesity and abnormal glucose tolerance. Chung ST, Katz LEL, Stettler-Davis N, Shults J, Sherman A, Ha J, Stefanovski D, Boston RC, Rader DJ, Magge SN. J Clin Endocrinol Metab. 2022 Mar 3:dgac113. doi: 10.1210/clinem/dgac113. Online ahead of print. PMID: 35240684
Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions. Conlon DM, Schneider CV, Ko YA, Rodrigues A, Guo K, Hand NJ, Rader DJ. J Clin Invest. 2022 Mar 15;132(6):e144334. doi: 10.1172/JCI144334. PMID: 35113816
A systematic review of the natural history and biomarkers of primary lecithin:cholesterol acyltransferase deficiency . Vitali C, Bajaj A, Nguyen C, Schnall J, Chen J, Stylianou K, Rader DJ, Cuchel M. J Lipid Res. 2022 Mar;63(3):100169. doi: 10.1016/j.jlr.2022.100169. Epub 2022 Jan 20. PMID: 35065092
Association of Telomere Length With Risk of Disease and Mortality. Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P. .JAMA Intern Med. 2022 Mar 1;182(3):291-300. doi: 10.1001/jamainternmed.2021.7804. PMID: 35040871
Early prediction of decompensation (EPOD) score: Non-invasive determination of cirrhosis decompensation risk. Schneider ARP, Schneider CV, Schneider KM, Baier V, Schaper S, Diedrich C, Coboeken K, Mayer H, Gu W, Trebicka J, Blank LM, Burghaus R, Lippert J, Rader DJ, Thaiss CA, Schlender JF, Trautwein C, Kuepfer L. Liver Int. 2022 Mar;42(3):640-650. doi: 10.1111/liv.15161. Epub 2022 Feb 3. PMID: 35007409
A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. Zhou J, Wu Y, Rauova L, Koma G, Wang L, Poncz M, Li H, Liu T, Fong KP, Bennett JS, Kunapuli SP, Essex DW. Blood. 2022 Mar 31;139(13):2050-2065. doi: 10.1182/blood.2021012055. PMID: 34752599
Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies. Zheng S, Gillespie E, Naqvi AS, Hayer KE, Ang Z, Torres-Diz M, Quesnel-Vallières M, Hottman DA, Bagashev A, Chukinas J, Schmidt C, Asnani M, Shraim R, Taylor DM, Rheingold SR, O'Brien MM, Singh N, Lynch KW, Ruella M, Barash Y, Tasian SK, Thomas-Tikhonenko A. Blood Cancer Discov. 2022 Mar 1;3(2):103-115. doi: 10.1158/2643-3230.BCD-21-0087. PMID: 35015683
Erosive hand osteoarthritis: latest findings and outlook . Favero M, Belluzzi E, Ortolan A, Lorenzin M, Oliviero F, Doria A, Scanzello CR, Ramonda R. Nat Rev Rheumatol. 2022 Mar;18(3):171-183. doi: 10.1038/s41584-021-00747-3. Epub 2022 Feb 1. PMID: 35105980
Differentiating children with sepsis with and without acute respiratory distress syndrome using proteomics. Yehya N, Fazelinia H, Taylor DM, Lawrence GG, Spruce LA, Thompson JM, Margulies SS, Seeholzer SH, Worthen GS. Am J Physiol Lung Cell Mol Physiol. 2022 Mar 1;322(3):L365-L372. doi: 10.1152/ajplung.00164.2021. Epub 2022 Jan 5. PMID: 34984927
Bleach baths for atopic dermatitis: A systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE. Bakaa L, Pernica JM, Couban RJ, Tackett KJ, Burkhart CN, Leins L, Smart J, Garcia-Romero MT, Elizalde-Jiménez IG, Herd M, Asiniwasis RN, Boguniewicz M, De Benedetto A, Chen L, Ellison K, Frazier W, Greenhawt M, Huynh J, LeBovidge J, Lind ML, Lio P, O'Brien M, Ong PY, Silverberg JI, Spergel JM, Wang J, Begolka WS, Schneider L, Chu DK. Ann Allergy Asthma Immunol. 2022 Mar 30:S1081-1206(22)00286-1. doi: 10.1016/j.anai.2022.03.024. Online ahead of print. PMID: 35367346
Annals editors on the war in Ukraine. Grayson MH, Borish L, Castells MC, Greenhawt MJ, Leung DYM, Lieberman JA, Marshall GD, Nowak-Wegrzyn A, Oppenheimer J, Shaker MS, Shulenberger K, Spergel J, Stukus DR. Ann Allergy Asthma Immunol. 2022 Mar 24:S1081-1206(22)00209-5. doi: 10.1016/j.anai.2022.03.018. Online ahead of print. PMID: 35342018
Development of Food Allergy Data Dictionary: Toward a Food Allergy Data Commons. Sehgal S, Gupta RS, Wlodarski M, Bilaver LA, Wehbe FH, Spergel JM, Wang J, Ciaccio CE, Makhija M, Starren JB. J Allergy Clin Immunol Pract. 2022 Mar 5:S2213-2198(22)00225-2. doi: 10.1016/j.jaip.2022.02.024. Online ahead of print. PMID: 35259539
Adverse events and labeling issues related to suspected sesame allergy reported in an online survey. Nguyen K, Greenthal E, Sorscher S, Lurie P, Spergel JM, Kennedy K. Ann Allergy Asthma Immunol. 2022 Mar;128(3):279-282. doi: 10.1016/j.anai.2021.12.005. Epub 2021 Dec 7. PMID: 34883240
Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer. Sela Y, Li J, Maheswaran S, Norgard RJ, Yuan S, Hubbi ME, Doepner M, Xu JP, Ho ES, Mesaros C, Sheehan C, Croley G, Muir A, Blair IA, Shalem O, Dang CV, Stanger BZ. Cancer Res. 2022 Mar 22:canres.CAN-22-0431-E.2022. doi: 10.1158/0008-5472.CAN-22-0431. Online ahead of print. PMID: 35315913
KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs. Yan F, Li J, Milosevic J, Petroni R, Liu S, Shi Z, Yuan S, Reynaga JM, Qi Y, Rico J, Yu S, Liu Y, Rokudai S, Palmisiano N, Meyer SE, Sung PJ, Wan L, Lan F, Garcia BA, Stanger BZ, Sykes DB, Blanco MA. Cancer Discov. 2022 Mar 1;12(3):792-811. doi: 10.1158/2159-8290.CD-20-1459. PMID: 34853079
The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. Gourmaud S, Stewart DA, Irwin DJ, Roberts N, Barbour AJ, Eberwine G, O'Brien WT, Vassar R, Talos DM, Jensen FE. Brain. 2022 Mar 29;145(1):324-339. doi: 10.1093/brain/awab268. PMID: 34264340
Children's Oncology Group Trial AALL1231: A Phase III Clinical Trial Testing Bortezomib in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia and Lymphoma. Teachey DT, Devidas M, Wood BL, Chen Z, Hayashi RJ, Hermiston ML, Annett RD, Archer JH, Asselin BL, August KJ, Cho SY, Dunsmore KP, Fisher BT, Freedman JL, Galardy PJ, Harker-Murray P, Horton TM, Jaju AI, Lam A, Messinger YH, Miles RR, Okada M, Patel SI, Schafer ES, Schechter T, Singh N, Steele AC, Sulis ML, Vargas SL, Winter SS, Wood C, Zweidler-McKay P, Bollard CM, Loh ML, Hunger SP, Raetz EA. J Clin Oncol. 2022 Mar 10:JCO2102678. doi: 10.1200/JCO.21.02678. Online ahead of print. PMID: 35271306
Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies. Zheng S, Gillespie E, Naqvi AS, Hayer KE, Ang Z, Torres-Diz M, Quesnel-Vallières M, Hottman DA, Bagashev A, Chukinas J, Schmidt C, Asnani M, Shraim R, Taylor DM, Rheingold SR, O'Brien MM, Singh N, Lynch KW, Ruella M, Barash Y, Tasian SK, Thomas-Tikhonenko A. Blood Cancer Discov. 2022 Mar 1;3(2):103-115. doi: 10.1158/2643-3230.BCD-21-0087. PMID: 35015683
Stripenn detects architectural stripes from chromatin conformation data using computer vision. Yoon S, Chandra A, Vahedi G. Nat Commun. 2022 Mar 24;13(1):1602. doi: 10.1038/s41467-022-29258-9. PMID: 35332165
Trefoil Factor Family: A Troika for Lung Repair and Regeneration. Rossi HL, Ortiz-Carpena JF, Tucker D, Vaughan AE, Mangalmurti NS, Cohen NA, Herbert DR. Am J Respir Cell Mol Biol. 2022 Mar;66(3):252-259. doi: 10.1165/rcmb.2021-0373TR. PMID: 34784491
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity. Zhang D, Atochina-Vasserman EN, Lu J, Maurya DS, Xiao Q, Liu M, Adamson J, Ona N, Reagan EK, Ni H, Weissman D, Percec V. J Am Chem Soc. 2022 Mar 23;144(11):4746-4753. doi: 10.1021/jacs.2c00273. Epub 2022 Mar 9. PMID: 35263098
Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus. Merrill JT, Werth VP, Furie R, van Vollenhoven R, Dörner T, Petronijevic M, Velasco J, Majdan M, Irazoque-Palazuelos F, Weiswasser M, Korish S, Ye Y, Gaudy A, Schafer PH, Liu Z, Agafonova N, Delev N. N Engl J Med. 2022 Mar 17;386(11):1034-1045. doi: 10.1056/NEJMoa2106535. PMID: 35294813
Correction to: Cannabinoid type 2 receptor (CB2R) distribution in dermatomyositis skin and peripheral blood mononuclear cells (PBMCs) and in vivo efects of Lenabasum^TM. Maddukuri S, Patel J, Diaz A, Chen KL, Wysocka M, Bax C, Li Y, Ravishankar A, Grinnell M, Zeidi M, Reddy N, Concha JSS, Bashir MM, Okawa J, White B, Werth VP. Arthritis Res Ther. 2022 Mar 11;24(1):69. doi: 10.1186/s13075-022-02758-1. PMID: 35277198
Mycophenolate Mofetil and Methotrexate Efficacy in Dermatomyositis. Grinnell M, Keyes E, Diaz D, Vazquez T, Feng R, Werth VP. Br J Dermatol. 2022 Mar 8. doi: 10.1111/bjd.21235. Online ahead of print. PMID: 35257367
T cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma. Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D'Alessio A, Pinato DJ, Bettinger D, Binder H, Wherry EJ, Schultheiss M, Thimme R, Bengsch B. J Hepatol. 2022 Mar 31:S0168-8278(22)00180-5. doi: 10.1016/j.jhep.2022.02.032. Online ahead of print. PMID: 35367533
Multi-ethnic Investigation of Risk and Immune Determinants of COVID-19 Outcomes. Jun T, Mathew D, Sharma N, Nirenberg S, Huang HH, Kovatch P, Wherry EJ, Huang KL. Res Sq. 2022 Mar 22:rs.3.rs-1055587. doi: 10.21203/rs.3.rs-1055587/v1. Preprint. PMID: 35350196
Understanding T-cell responses to COVID-19 is essential for informing public health strategies. Vardhana S, Baldo L, Morice WG 2nd, Wherry EJ. Sci Immunol. 2022 Mar 24:eabo1303. doi: 10.1126/sciimmunol.abo1303. Online ahead of print. PMID: 35324269
Inhibiting the β1integrin subunit increases the strain threshold for neuronal dysfunction under tensile loading in collagen gels mimicking innervated ligaments . Singh S, Winkelstein BA. Biomech Model Mechanobiol. 2022 Mar 12. doi: 10.1007/s10237-022-01565-6. Online ahead of print. PMID: 35279768
The Macronutrient Composition of Infant Formula Produces Differences in Gut Microbiota Maturation That Associate with Weight Gain Velocity and Weight Status. Mennella JA, Li Y, Bittinger K, Friedman ES, Zhao C, Li H, Wu GD, Trabulsi JC. Nutrients. 2022 Mar 15;14(6):1241. doi: 10.3390/nu14061241. PMID: 35334900
Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori-induced inflammation-driven gastric carcinogenesis . Noto JM, Piazuelo MB, Shah SC, Romero-Gallo J, Hart JL, Di C, Carmichael JD, Delgado AG, Halvorson AE, Greevy RA Jr, Wroblewski LE, Sharma A, Newton AB, Allaman MM, Wilson KT, Washington MK, Calcutt MW, Schey KL, Cummings BP, Flynn CR, Zackular JP, Peek RM Jr. J Clin Invest. 2022 Mar 22:e147822. doi: 10.1172/JCI147822. Online ahead of print. PMID: 35316215

February 2022

Batf-mediated epigenetic control of effector CD8 + T cell differentiation. Tsao HW, Kaminski J, Kurachi M, Barnitz RA, DiIorio MA, LaFleur MW, Ise W, Kurosaki T, Wherry EJ, Haining WN, Yosef N. Sci Immunol. 2022 Feb 18;7(68):eabi4919. doi: 10.1126/sciimmunol.abi4919. Epub 2022 Feb 18. PMID: 35179948
Cytomegalovirus latent infection is associated with an increased risk of COVID-19-related hospitalization. Alanio C, Verma A, Mathew D, Gouma S, Liang G, Dunn T, Oldridge DA, Weaver JE, Kuri-Cervantes L, Pampena MB; UPenn COVID Processing Unit, Betts MR, Collman RG, Bushman FD, Meyer NJ, Hensley SE, Rader D, Wherry EJ. J Infect Dis. 2022 Feb 2:jiac020. doi: 10.1093/infdis/jiac020. Online ahead of print. PMID: 35134186
Decade-long leukaemia remissions with persistence of CD4 + CAR T cells. Melenhorst JJ, Chen GM, Wang M, Porter DL, Chen C, Collins MA, Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, Gill SI, Tian L, Kulikovskaya I, Gupta M, Ambrose DE, Davis MM, Fraietta JA, Brogdon JL, Young RM, Chew A, Levine BL, Siegel DL, Alanio C, Wherry EJ, Bushman FD, Lacey SF, Tan K, June CH. Nature. 2022 Feb;602(7897):503-509. doi: 10.1038/s41586-021-04390-6. Epub 2022 Feb 2. PMID: 35110735
Development of Droplet Digital PCR-Based Assays to Quantify HIV Proviral and Integrated DNA in Brain Tissues from Viremic Individuals with Encephalitis and Virally Suppressed Aviremic Individuals. Chung HK, Hattler JB, Narola J, Babbar H, Cai Y, Abdel-Mohsen M, Kim WK. Microbiol Spectr. 2022 Feb 23;10(1):e0085321. doi: 10.1128/spectrum.00853-21. Epub 2022 Jan 12. PMID: 35019681
Thromboelastography profiles for controlled circulatory death donors: Validating the role of heparin. Crannell WC, Sally M, McConnell K, Connelly C, Maynard E, Dewey E, Abt P, Enestvedt CK. Clin Transplant. 2022 Feb;36(2):e14518. doi: 10.1111/ctr.14518. Epub 2021 Nov 29. PMID: 34668240
Clinical Applications of Somatostatin Receptor (Agonist) PET Tracers beyond Neuroendocrine Tumors. Helgebostad R, Revheim ME, Johnsrud K, Amlie K, Alavi A, Connelly JP. Diagnostics (Basel). 2022 Feb 18;12(2):528. doi: 10.3390/diagnostics12020528. PMID: 35204618
Advantages and Applications of Total-Body PET Scanning. Katal S, Eibschutz LS, Saboury B, Gholamrezanezhad A, Alavi A. Diagnostics (Basel). 2022 Feb 7;12(2):426. doi: 10.3390/diagnostics12020426. PMID: 35204517
Letermovir vs. high-dose valacyclovir for cytomegalovirus prophylaxis following haploidentical or mismatched unrelated donor allogeneic hematopoietic cell transplantation receiving post-transplant cyclophosphamide. Freyer CW, Carulli A, Gier S, Ganetsky A, Timlin C, Schuster M, Babushok D, Frey NV, Gill SI, Hexner EO, Luger SM, Mangan JK, Martin ME, McCurdy SR, Perl AE, Porter DL, Pratz K, Smith J, Stadtmauer EA, Loren AW. Leuk Lymphoma. 2022 Feb 20:1-9. doi: 10.1080/10428194.2022.2042686. Online ahead of print. PMID: 35188052
Vaccine Response in Patients With Multiple Sclerosis Receiving Teriflunomide. Tornatore C, Wiendl H, Lublin AL, Geertsen SS, Chavin J, Truffinet P, Bar-Or A. Front Neurol. 2022 Feb 28;13:828616. doi: 10.3389/fneur.2022.828616. eCollection 2022. PMID: 35295832 PMCID: PMC8918991
The health-related quality of life of children with multiple sclerosis is mediated by the health-related quality of life of their parents. O'Mahony J, Banwell B, Laporte A, Brown A, Bolongaita L, Bar-Or A, Yeh EA, Marrie RA. Mult Scler. 2022 Feb 7:13524585211061521. doi: 10.1177/13524585211061521. Online ahead of print. PMID: 35130081
Worsening physical functioning in patients with neuroinflammatory disease during the COVID-19 pandemic. Levit E, Cohen I, Dahl M, Edwards K, Weinstock-Guttman B, Ishikawa T, Kavak K, Leavitt V, Nelson K, Onomichi K, Bar-Or A, Perrone C, Riley C, Venkatesh S, De Jager PL, Xia Z, Longbrake EE; Multiple Sclerosis Resilience to COVID-19 (MSReCOV) Collaborative. Mult Scler Relat Disord. 2022 Feb;58:103482. doi: 10.1016/j.msard.2021.103482. Epub 2022 Jan 4. PMID: 35016114
Lymphocytes Utilize Somatic Mutations, Epigenetic Silencing, and the Proteasome to Escape Truncated WASP Expression. Khanna C, Le Coz C, Vaccaro C, Pillarisetti P, Knox AVC, Sy A, Behrens EM, Buchbinder D, Romberg N. J Clin Immunol. 2022 Feb 12. doi: 10.1007/s10875-022-01224-6. Online ahead of print. PMID: 35149963
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes. Fasolino M, Schwartz GW, Patil AR, Mongia A, Golson ML, Wang YJ, Morgan A, Liu C, Schug J, Liu J, Wu M, Traum D, Kondo A, May CL, Goldman N, Wang W, Feldman M, Moore JH, Japp AS, Betts MR; HPAP Consortium, Faryabi RB, Naji A, Kaestner KH, Vahedi G. Nat Metab. 2022 Feb;4(2):284-299. doi: 10.1038/s42255-022-00531-x. Epub 2022 Feb 28. PMID: 35228745
Unrelated donor α/β T cell- and B cell-depleted HSCT for the treatment of pediatric acute leukemia. Leahy AB, Li Y, Talano JA, Elgarten CW, Seif AE, Wang Y, Johnson B, Monos DS, Kadauke S, Olson TS, Freedman J, Wray L, Grupp SA, Bunin N. Blood Adv. 2022 Feb 22;6(4):1175-1185. doi: 10.1182/bloodadvances.2021005492. PMID: 34872106
Cost Utility of Lifelong Immunoglobulin Replacement Therapy vs Hematopoietic Stem Cell Transplant to Treat Agammaglobulinemia. Sun D, Heimall JR, Greenhawt MJ, Bunin NJ, Shaker MS, Romberg N. JAMA Pediatr. 2022 Feb 1;176(2):176-184. doi: 10.1001/jamapediatrics.2021.4583. PMID: 34779842
Genetic and phenotypic characteristics of Clostridium (Clostridioides) difficile from canine, bovine, and pediatric populations. Redding LE, Tu V, Abbas A, Alvarez M, Zackular JP, Gu C, Bushman FD, Kelly DJ, Barnhart D, Lee JJ, Bittinger KL. Anaerobe. 2022 Feb 23:102539. doi: 10.1016/j.anaerobe.2022.102539. Online ahead of print. PMID: 35217150
SARS-CoV-2 Delta Variant (AY.3) in the Feces of a Domestic Cat. Lenz OC, Marques AD, Kelly BJ, Rodino KG, Cole SD, Perera RAPM, Weiss SR, Bushman FD, Lennon EM. Viruses. 2022 Feb 17;14(2):421. doi: 10.3390/v14020421. PMID: 35216014
Rapid manufacturing of non-activated potent CAR T cells. Ghassemi S, Durgin JS, Nunez-Cruz S, Patel J, Leferovich J, Pinzone M, Shen F, Cummins KD, Plesa G, Cantu VA, Reddy S, Bushman FD, Gill SI, O'Doherty U, O'Connor RS, Milone MC. Nat Biomed Eng. 2022 Feb;6(2):118-128. doi: 10.1038/s41551-021-00842-6. Epub 2022 Feb 21. PMID: 35190680
Detection and Interspecies Comparison of SARS-CoV-2 Delta Variant (AY.3) in Feces from a Domestic Cat and Human Samples. Lenz OC, Marques AD, Kelly BJ, Rodino KG, Cole SD, Perera RAPM, Weiss SR, Bushman FD, Lennon EM. bioRxiv. 2022 Feb 2:2022.01.31.478506. doi: 10.1101/2022.01.31.478506. Preprint. PMID: 35132417
SARS-CoV-2 Variants Associated with Vaccine Breakthrough in the Delaware Valley through Summer 2021. Marques AD, Sherrill-Mix S, Everett JK, Reddy S, Hokama P, Roche AM, Hwang Y, Glascock A, Whiteside SA, Graham-Wooten J, Khatib LA, Fitzgerald AS, Moustafa AM, Bianco C, Rajagopal S, Helton J, Deming R, Denu L, Ahmed A, Kitt E, Coffin SE, Newbern C, Mell JC, Planet PJ, Badjatia N, Richards B, Wang ZX, Cannuscio CC, Strelau KM, Jaskowiak-Barr A, Cressman L, Loughrey S, Ganguly A, Feldman MD, Collman RG, Rodino KG, Kelly BJ, Bushman FD. mBio. 2022 Feb 8;13(1):e0378821. doi: 10.1128/mbio.03788-21. Online ahead of print. PMID: 35130727
Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation . Anderko RR, Gómez H, Canna SW, Shakoory B, Angus DC, Yealy DM, Huang DT, Kellum JA, Carcillo JA; ProCESS Investigators. Intensive Care Med Exp. 2022 Feb 21;10(1):6. doi: 10.1186/s40635-022-00433-y. PMID: 35190900
Serum proteome analysis of systemic JIA and related lung disease identifies distinct inflammatory programs and biomarkers. Chen G, Deutsch GH, Schulert G, Zheng H, Jang S, Trapnell B, Lee P, Macaubas C, Ho K, Schneider C, Saper VE, de Jesus AA, Krasnow M, Grom A, Goldbach-Mansky R, Khatri P, Mellins ED, Canna SW. Arthritis Rheumatol. 2022 Feb 21. doi: 10.1002/art.42099. Online ahead of print. PMID: 35189047
NEMO-NDAS: A Panniculitis in the Young Representing an Autoinflammatory Disorder in Disguise. Hegazy S, Marques MC, Canna SW, Goldbach-Mansky R, de Jesus AA, Reyes-Múgica M, Salgado CM. Am J Dermatopathol. 2022 Feb 2. doi: 10.1097/DAD.0000000000002144. Online ahead of print. PMID: 35120036
Forging Forward in Photodynamic Therapy . Cramer GM, Cengel KA, Busch TM. Cancer Res. 2022 Feb 15;82(4):534-536. doi: 10.1158/0008-5472.CAN-21-4122. PMID: 35180305
Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci. Bellomo TR, Bone WP, Chen BY, Gawronski KAB, Zhang D, Park J, Levin M, Tsao N, Klarin D, Lynch J, Assimes TL, Gaziano JM, Wilson PW, Cho K, Vujkovic M, O'Donnell CJ, Chang KM, Tsao PS, Rader DJ, Ritchie MD, Damrauer SM, Voight BF. Front Genet. 2022 Feb 2;12:787545. doi: 10.3389/fgene.2021.787545. eCollection 2021. PMID: 35186008
Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages. Acheampong KK, Schaff DL, Emert BL, Lake J, Reffsin S, Shea EK, Comar CE, Litzky LA, Khurram NA, Linn RL, Feldman M, Weiss SR, Montone KT, Cherry S, Shaffer SM. mBio. 2022 Feb 8;13(1):e0375121. doi: 10.1128/mbio.03751-21. Online ahead of print. PMID: 35130722
NF-κB perturbation reveals unique immunomodulatory functions in Prx1⁺fibroblasts that promote development of atopic dermatitis. Ko KI, Merlet JJ, DerGarabedian BP, Zhen H, Suzuki-Horiuchi Y, Hedberg ML, Hu E, Nguyen AT, Prouty S, Alawi F, Walsh MC, Choi Y, Millar SE, Cliff A, Romero J, Garvin MR, Seykora JT, Jacobson D, Graves DT .Sci Transl Med. 2022 Feb 2;14(630):eabj0324. doi: 10.1126/scitranslmed.abj0324. Epub 2022 Feb 2. PMID: 35108061
Divergent impacts of tocilizumab and colchicine in COVID-19-associated coagulopathy: the role of alpha-defensins. Abdeen S, Abu-Fanne R, Bdeir K, Maraga E, Higazi M, Cines DB, Heyman SN, Higazi AA. Br J Haematol. 2022 Feb;196(4):923-927. doi: 10.1111/bjh.17885. Epub 2021 Oct 27. PMID: 34622440
SARS-CoV-2 Variants Associated with Vaccine Breakthrough in the Delaware Valley through Summer 2021. Marques AD, Sherrill-Mix S, Everett JK, Reddy S, Hokama P, Roche AM, Hwang Y, Glascock A, Whiteside SA, Graham-Wooten J, Khatib LA, Fitzgerald AS, Moustafa AM, Bianco C, Rajagopal S, Helton J, Deming R, Denu L, Ahmed A, Kitt E, Coffin SE, Newbern C, Mell JC, Planet PJ, Badjatia N, Richards B, Wang ZX, Cannuscio CC, Strelau KM, Jaskowiak-Barr A, Cressman L, Loughrey S, Ganguly A, Feldman MD, Collman RG, Rodino KG, Kelly BJ, Bushman FD. mBio. 2022 Feb 8;13(1):e0378821. doi: 10.1128/mbio.03788-21. Online ahead of print. PMID: 35130727
Synthetic Antibiotic Derived from Sequences Encrypted in a Protein from Human Plasma. Cesaro A, Torres MDT, Gaglione R, Dell'Olmo E, Di Girolamo R, Bosso A, Pizzo E, Haagsman HP, Veldhuizen EJA, de la Fuente-Nunez C, Arciello A. ACS Nano. 2022 Feb 22;16(2):1880-1895. doi: 10.1021/acsnano.1c04496. Epub 2022 Feb 3. PMID: 35112568
External Beam Radiation Therapy for Primary Liver Cancers: An ASTRO Clinical Practice Guideline. Apisarnthanarax S, Barry A, Cao M, Czito B, DeMatteo R, Drinane M, Hallemeier CL, Koay EJ, Lasley F, Meyer J, Owen D, Pursley J, Schaub SK, Smith G, Venepalli NK, Zibari G, Cardenes H. Pract Radiat Oncol. 2022 Jan-Feb;12(1):28-51. doi: 10.1016/j.prro.2021.09.004. Epub 2021 Oct 21. PMID: 34688956
Prediction of Incident Heart Failure in CKD: The CRIC Study. Zelnick LR, Shlipak MG, Soliman EZ, Anderson A, Christenson R, Kansal M, Deo R, He J, Jaar BG, Weir MR, Rao P, Cohen DL, Cohen JB, Feldman HI, Go A, Bansal N; CRIC Study Investigators Kidney Int Rep. 2022 Feb 2;7(4):708-719. doi: 10.1016/j.ekir.2022.01.1067. eCollection 2022 Apr. PMID: 35497796
Teaming up to return to play: A shared responsibility to optimize care . Chokshi NP, Deo R. Heart Rhythm O2. 2022 Feb 22;3(2):141-142. doi: 10.1016/j.hroo.2022.02.012. eCollection 2022 Apr. PMID: 35496456
Fluticasone Propionate Orally Disintegrating Tablet (APT-1011) for Eosinophilic Esophagitis: Randomized Controlled Trial. Dellon ES, Lucendo AJ, Schlag C, Schoepfer AM, Falk GW, Eagle G, Nezamis J, Comer GM, Knoop K, Hirano I. Clin Gastroenterol Hepatol. 2022 Feb 16:S1542-3565(22)00139-2. doi: 10.1016/j.cgh.2022.02.013. Online ahead of print. PMID: 35181572
Mast cell-pain connection in eosinophilic esophagitis . Zhang S, Shoda T, Aceves SS, Arva NC, Chehade M, Collins MH, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Khoury P, Leung J, Spergel AKR, Spergel JM, Wechsler JB, Yang GY, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators Group. Allergy. 2022 Feb 17. doi: 10.1111/all.15260. Online ahead of print. PMID: 35175645
R eliability and responsiveness of endoscopic disease activity assessment in eosinophilic esophagitis. Ma C, Bredenoord AJ, Dellon ES, Alexander JA, Biedermann L, Hogan M, Guizzetti L, Zou G, Katzka DA, Chehade M, Falk GW, Furuta GT, Gupta SK, Kagalwalla AF, Schoepfer AM, Miehlke S, Moawad FJ, Peterson K, Gonsalves NP, Straumann A, Wechsler JB, Rémillard J, Shackelton LM, Almonte HS, Feagan BG, Jairath V, Hirano I. Gastrointest Endosc. 2022 Feb 1:S0016-5107(22)00082-7. doi: 10.1016/j.gie.2022.01.014. Online ahead of print. PMID: 35120883
Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis. Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES. Am J Gastroenterol. 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022
LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer. Murray CW, Brady JJ, Han M, Cai H, Tsai MK, Pierce SE, Cheng R, Demeter J, Feldser DM, Jackson PK, Shackelford DB, Winslow MM. Nat Commun. 2022 Feb 28;13(1):1090. doi: 10.1038/s41467-022-28619-8. PMID: 35228570
A retrospective study of HIV pre-exposure prophylaxis counselling among non-Hispanic Black youth diagnosed with bacterial sexually transmitted infections in the United States, 2014-2019. Watson DL, Shaw PA, Petsis DT, Pickel J, Bauermeister JA, Frank I, Wood SM, Gross R. J Int AIDS Soc. 2022 Feb;25(2):e25867. doi: 10.1002/jia2.25867. PMID: 35192740
Sedation and Analgesia in Patients Undergoing Tracheostomy in COVID-19, a Multi-Center Registry. Kapp CM, Latifi A, Feller-Kopman D, Atkins JH, Ben Or E, Dibardino D, Haas AR, Thiboutot J, Hutchinson CT. J Intensive Care Med. 2022 Feb;37(2):240-247. doi: 10.1177/08850666211045896. Epub 2021 Oct 12. PMID: 34636705
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine. Goel RR, Painter MM, Lundgreen KA, Apostolidis SA, Baxter AE, Giles JR, Mathew D, Pattekar A, Reynaldi A, Khoury DS, Gouma S, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Kc W, Oldridge DA, Erickson RI, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O, Drapeau EM, Davenport MP, Hensley SE, Bates P, Greenplate AR, Wherry EJ. bioRxiv. 2022 Feb 22:2022.02.20.481163. doi: 10.1101/2022.02.20.481163. Preprint. PMID: 35233575
Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody. Kamoun M, Askar M, Kearns JD, Bui TM, Nguyen M, Brown NK, Duquesnoy RJ. Hum Immunol. 2022 Feb;83(2):99-106. doi: 10.1016/j.humimm.2021.11.001. Epub 2021 Nov 20. PMID: 34815108
Patterns of germline and somatic testing after universal tumor screening for Lynch syndrome: A clinical practice survey of active members of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer. Hodan R, Rodgers-Fouche L, Arora S, Dominguez-Valentin M, Kanth P, Katona BW, Mraz KA, Roberts ME, Vilar E, Soto-Azghani CM, Brand RE, Esplin ED, Perez K. J Genet Couns. 2022 Feb 26. doi: 10.1002/jgc4.1567. Online ahead of print. PMID: 35218578
Upper Gastrointestinal Cancer Surveillance in Lynch Syndrome . Kumar S, Farha N, Burke CA, Katona BW. Cancers(Basel). 2022 Feb 16;14(4):1000. doi: 10.3390/cancers14041000. PMID: 35205747
Detection of Early-Stage Pancreatic Ductal Adenocarcinoma From Blood Samples: Results of a Multiplex Biomarker Signature Validation Study . Brand RE, Persson J, Bratlie SO, Chung DC, Katona BW, Carrato A, Castillo M, Earl J, Kokkola A, Lucas AL, Moser AJ, DeCicco C, Mellby LD, King TC.Clin Transl Gastroenterol. 2022 Feb 14;13(3):e00468. doi: 10.14309/ctg.0000000000000468. PMID: 35166713
Quo Vadis Anesthesiologist? The Value Proposition of Future Anesthesiologists Lies in Preserving or Restoring Presurgical Health after Surgical Insult. Laudanski K .J Clin Med. 2022 Feb 21;11(4):1135. doi: 10.3390/jcm11041135. PMID: 35207406
Cellular Memories - More Than Skin Deep. Leung TH, Cotsarelis G. N Engl J Med. 2022 Feb 24;386(8):793-795. doi: 10.1056/NEJMcibr2118516. PMID: 35196433
Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic β cells and lowers blood glucose in diabetic mice . Ramu Y, Yamakaze J, Zhou Y, Hoshi T, Lu Z. Elife. 2022 Feb 25;11:e77026. doi: 10.7554/eLife.77026. PMID: 35212627
Publisher Correction: Ventral striatal islands of Calleja neurons control grooming in mice . Zhang YF, Vargas Cifuentes L, Wright KN, Bhattarai JP, Mohrhardt J, Fleck D, Janke E, Jiang C, Cranfill SL, Goldstein N, Schreck M, Moberly AH, Yu Y, Arenkiel BR, Betley JN, Luo W, Stegmaier J, Wesson DW, Spehr M, Fuccillo MV, Ma M. Nat Neurosci. 2022 Feb;25(2):264. doi: 10.1038/s41593-021-01003-3. PMID: 34992258
BET-bromodomain and EZH2 inhibitor treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes. Zaiken MC, Flynn R, Paz KG, Rhee SY, Jin S, Mohamed FA, Saha A, Thangavelu G, Park PMC, Hemming ML, Sage PT, Sharpe AH, DuPage M, Bluestone JA, Panoskaltsis-Mortari A, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Luznik L, Maillard I, Hill GR, MacDonald KP, Munn DH, Serody JS, Murphy WJ, Kean LS, Zhang Y, Bradner JE, Qi J, Blazar BR. Blood. 2022 Feb 28:blood.2021014557. doi: 10.1182/blood.2021014557. Online ahead of print. PMID: 35226736
The effects of plasma exchange in patients with ANCA-associated vasculitis: an updated systematic review and meta-analysis. Walsh M, Collister D, Zeng L, Merkel PA, Pusey CD, Guyatt G, Au Peh C, Szpirt W, Ito-Hara T, Jayne DRW; Plasma exchange and glucocorticoid dosing for patients with ANCA-associated vasculitis BMJ Rapid Recommendations Group. BMJ. 2022 Feb 25;376:e064604. doi: 10.1136/bmj-2021-064604. PMID: 35217545
A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects. Belvitch P, Casanova N, Sun X, Camp SM, Sammani S, Brown ME, Mascarhenas J, Lynn H, Adyshev D, Siegler J, Desai A, Seyed-Saadat L, Rizzo A, Bime C, Shekhawat GS, Dravid VP, Reilly JP, Jones TK, Feng R, Letsiou E, Meyer NJ, Ellis N, Garcia JGN, Dudek SM. Transl Res. 2022 Feb 15:S1931-5244(22)00022-6. doi: 10.1016/j.trsl.2022.02.002. Online ahead of print. PMID: 35181549
Lighting the way to personalized mRNA immune cell therapies. Metzloff AE, Billingsley MM, Mitchell MJ. Sci Adv. 2022 Feb 25;8(8):eabo2423. doi: 10.1126/sciadv.abo2423. Epub 2022 Feb 23. PMID: 35196095
Preliminary Acceptability of a Home-Based Peripheral Blood Collection Device for Viral Load Testing in the Context of Analytical Treatment Interruptions in HIV Cure Trials: Results from a Nationwide Survey in the United States. Dubé K, Eskaf S, Hastie E, Agarwal H, Henley L, Roebuck C, Carter WB, Dee L, Taylor J, Mapp D, Campbell DM, Villa TJ, Peterson B, Lynn KM, Lalley-Chareczko L, Hiserodt E, Kim S, Rosenbloom D, Evans BR, Anderson M, Hazuda DJ, Shipley L, Bateman K, Howell BJ, Mounzer K, Tebas P, Montaner LJ. J Pers Med. 2022 Feb 7;12(2):231. doi: 10.3390/jpm12020231. PMID: 35207719
PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for Immunogenicity in BRCA-Deficient Ovarian Cancer. Kraya AA, Maxwell KN, Eiva MA, Wubbenhorst B, Pluta J, Feldman M, Nayak A, Powell DJ Jr, Domchek SM, Vonderheide RH, Nathanson KL. JCO Precis Oncol. 2022 Feb;6:e2100159. doi: 10.1200/PO.21.00159. PMID: 35201851
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine. Muramatsu H, Lam K, Bajusz C, Laczkó D, Karikó K, Schreiner P, Martin A, Lutwyche P, Heyes J, Pardi N. Mol Ther. 2022 Feb 4;30(5):1941-51. doi: 10.1016/j.ymthe.2022.02.001. Online ahead of print. PMID: 35131437
Response to Letter to Editor re: "Combined Quantification of 18F-FDG and 68Ga-DOTATATE PET/CT for Prognosis in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms". Lee H, Nakamoto R, Moore SE, Pantel AR, Eads JR, Aparici CM, Pryma DA. Acad Radiol. 2022 Feb 26:S1076-6332(22)00107-6. doi: 10.1016/j.acra.2022.02.001. Online ahead of print. PMID: 35227613
Managing a High-Specific-Activity Iobenguane Therapy Clinic: From Operations to Reimbursement. O'Brien SR, Pryma DA. J Nucl Med. 2022 Feb;63(2):196-198. doi: 10.2967/jnumed.121.262306. Epub 2021 Dec 2. PMID: 34857657
Loss of p19Arf promotes fibroblast survival during leucine deprivation. Roby KC, Lieberman A, Kim BJ, Rodríguez NZ, Posimo JM, Tsang T, Verginadis II, Puré E, Brady DC, Koumenis C, Ryeom S. Biol Open. 2022 Feb 15;11(2):bio058728. doi: 10.1242/bio.058728. Epub 2022 Feb 17. PMID: 34994382
Cost Utility of Lifelong Immunoglobulin Replacement Therapy vs Hematopoietic Stem Cell Transplant to Treat Agammaglobulinemia. Sun D, Heimall JR, Greenhawt MJ, Bunin NJ, Shaker MS, Romberg N .JAMA Pediatr. 2022 Feb 1;176(2):176-184. doi: 10.1001/jamapediatrics.2021.4583. PMID: 34779842
Epigenetic Regulation of Apoptosis in Cutaneous T-Cell Lymphoma: Implications for Therapy with Methotrexate, Jak Inhibitors, and Resveratrol. Nihal M, Wu J, Stonesifer CJ, Daniels J, Choi J, Geskin L, Rook AH, Wood GS. J Invest Dermatol. 2022 Feb;142(2):493-496.e7. doi: 10.1016/j.jid.2021.06.034. Epub 2021 Aug 3. PMID: 34358529
Orofacial Granulomatosis Treated With Combination of Intralesional Steroids and Hydroxychloroquine. Bindakhil MA, Stoopler ET, Alawai F, Sollecito TP. Compend Contin Educ Dent. 2022 Feb;43(2):e1-e4. PMID: 35148477
A Pernicious Cycle Affecting Premalignant Stem Cells. Speck NA. N Engl J Med. 2022 Feb 10;386(6):596-598. doi: 10.1056/NEJMcibr2117528. PMID: 35139279
Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis . Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES. Am J Gastroenterol. 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022
Epigenetic state determines inflammatory sensing in neuroblastoma. Wolpaw AJ, Grossmann LD, Dessau JL, Dong MM, Aaron BJ, Brafford PA, Volgina D, Pascual-Pasto G, Rodriguez-Garcia A, Uzun Y, Arsenian-Henriksson M, Powell DJ Jr, Bosse KR, Kossenkov A, Tan K, Hogarty MD, Maris JM, Dang CV. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2102358119. doi: 10.1073/pnas.2102358119. PMID: 35121657
Preliminary Acceptability of a Home-Based Peripheral Blood Collection Device for Viral Load Testing in the Context of Analytical Treatment Interruptions in HIV Cure Trials: Results from a Nationwide Survey in the United States . Dubé K, Eskaf S, Hastie E, Agarwal H, Henley L, Roebuck C, Carter WB, Dee L, Taylor J, Mapp D, Campbell DM, Villa TJ, Peterson B, Lynn KM, Lalley-Chareczko L, Hiserodt E, Kim S, Rosenbloom D, Evans BR, Anderson M, Hazuda DJ, Shipley L, Bateman K, Howell BJ, Mounzer K, Tebas P, Montaner LJ. J Pers Med. 2022 Feb 7;12(2):231. doi: 10.3390/jpm12020231. PMID: 35207719
Aging disrupts circadian gene regulation and function in macrophages. Blacher E, Tsai C, Litichevskiy L, Shipony Z, Iweka CA, Schneider KM, Chuluun B, Heller HC, Menon V, Thaiss CA, Andreasson KI. Nat Immunol. 2022 Feb;23(2):229-236. doi: 10.1038/s41590-021-01083-0. Epub 2021 Dec 23. PMID: 34949832
Advances in integrative African genomics. Zhang C, Hansen MEB, Tishkoff SA. Trends Genet. 2022 Feb;38(2):152-168. doi: 10.1016/j.tig.2021.09.013. Epub 2021 Nov 2. PMID: 34740451
Systematic illumination of druggable genes in cancer genomes. Jiang J, Yuan J, Hu Z, Zhang Y, Zhang T, Xu M, Long M, Fan Y, Tanyi JL, Montone KT, Tavana O, Vonderheide RH, Chan HM, Hu X, Zhang L .Cell Rep. 2022 Feb 22;38(8):110400. doi: 10.1016/j.celrep.2022.110400 .PMID: 35196490
Bonded cumomer analysis of tumor metabolism based on ¹³ C magnetic resonance spectroscopy. Shestov AA, Nath K, Nelson DS, Wasik MA, Glickson JD. NMR Biomed. 2022 Feb 23:e4716. doi: 10.1002/nbm.4716. Online ahead of print. PMID: 35196744
Detection and Interspecies Comparison of SARS-CoV-2 Delta Variant (AY.3) in Feces from a Domestic Cat and Human Samples. Lenz OC, Marques AD, Kelly BJ, Rodino KG, Cole SD, Perera RAPM, Weiss SR, Bushman FD, Lennon EM. bioRxiv. 2022 Feb 2:2022.01.31.478506. doi: 10.1101/2022.01.31.478506. Preprint. PMID: 35132417
Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine . Li D, Martinez DR, Schäfer A, Chen H, Barr M, Sutherland LL, Lee E, Parks R, Mielke D, Edwards W, Newman A, Bock KW, Minai M, Nagata BM, Gagne M, Douek D, DeMarco CT, Denny TN, Oguin TH, Brown A, Rountree W, Wang Y, Mansouri K, Edwards RJ, Ferrari G, Sempowski GD, Eaton A, Tang J, Cain DW, Santra S, Pardi N, Weissman D, Tomai M, Fox C, Moore IN, Andersen H, Lewis MG, Golding H, Khurana S, Seder R, Baric RS, Montefiori DC, Saunders KO, Haynes BF. bioRxiv. 2022 Feb 14:2022.01.26.477915. doi: 10.1101/2022.01.26.477915. Preprint. PMID: 35118474
Schlafens Can Put Viruses to Sleep . Kim ET, Weitzman MD. Viruses. 2022 Feb 21;14(2):442. doi: 10.3390/v14020442. PMID: 35216035
Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA. Price AM, Steinbock RT, Di C, Hayer KE, Li Y, Herrmann C, Parenti NA, Whelan JN, Weiss SR, Weitzman MD. Nucleic Acids Res. 2022 Feb 22;50(3):1201-1220. doi: 10.1093/nar/gkab896 .PMID: 34671803
Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation. Li M, Lyu X, Liao J, Werth VP, Liu ML. Theranostics. 2022 Feb 7;12(5):2133-2149. doi: 10.7150/thno.66457. eCollection 2022. PMID: 35265203
Defining anti-synthetase syndrome: a systematic literature review. Zanframundo G, Faghihi-Kashani S, Scirè CA, Bonella F, Corte TJ, Doyle TJ, Fiorentino D, Gonzalez-Gay MA, Hudson M, Kuwana M, Lundberg IE, Mammen A, McHugh N, Miller FW, Monteccucco C, Oddis CV, Rojas-Serrano J, Schmidt J, Selva-O'Callaghan A, Werth VP, Sakellariou G, Aggarwal R, Cavagna L. Clin Exp Rheumatol. 2022 Feb;40(2):309-319. doi: 10.55563/clinexprheumatol/8xj0b9. Epub 2022 Feb 25. PMID: 35225224
Letter to the Editor Reply Regarding ACR White Paper on Antimalarials and Cardiac Toxicity: Suggested Amendments to Future Directions. Desmarais J, Rosenbaum JT, Costenbader KH, Ginzler EM, Fett N, Goodman S, O'Dell J, Pineau CA, Schmajuk G, Werth VP, Link MS, Kovacs R. Arthritis Rheumatol. 2022 Feb 25. doi: 10.1002/art.42102. Online ahead of print. PMID: 35212179
Iberdomide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled, ascending-dose, phase 2a study . Furie RA, Hough DR, Gaudy A, Ye Y, Korish S, Delev N, Weiswasser M, Zhan X, Schafer PH, Werth VP. Lupus Sci Med. 2022 Feb;9(1):e000581. doi: 10.1136/lupus-2021-000581. PMID: 35169036
A Microbial Signature for Pediatric Perianal Crohn's Disease. Breton J, Tanes C, Tu V, Albenberg L, Rowley S, Devas N, Hwang R, Kachelries K, Wu GD, Baldassano RN, Bittinger K, Mattei P. J Crohns Colitis. 2022 Feb 25:jjac032. doi: 10.1093/ecco-jcc/jjac032. Online ahead of print. PMID: 35211723

Jan 2022

NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. J Exp Med. 2022 Jan 3;219(1):e20201599. doi: 10.1084/jem.20201599. Epub 2021 Dec 9. PMID: 34882194 PMCID: PMC8666877
Lentiviral globin gene therapy with reduced-intensity conditioning in adults with β-thalassemia: a phase 1 trial. Boulad F, Maggio A, Wang X, Moi P, Acuto S, Kogel F, Takpradit C, Prockop S, Mansilla-Soto J, Cabriolu A, Odak A, Qu J, Thummar K, Du F, Shen L, Raso S, Barone R, Di Maggio R, Pitrolo L, Giambona A, Mingoia M, Everett JK, Hokama P, Roche AM, Cantu VA, Adhikari H, Reddy S, Bouhassira E, Mohandas N, Bushman FD, Rivière I, Sadelain M. Nat Med. 2022 Jan 3. doi: 10.1038/s41591-021-01554-9. Online ahead of print. PMID: 34980909
Potential and Most Relevant Applications of Total Body PET/CT Imaging. Alavi A, Saboury B, Nardo L, Zhang V, Wang M, Li H, Raynor WY, Werner TJ, Høilund-Carlsen PF, Revheim ME. Clin Nucl Med. 2022 Jan 1;47(1):43-55. doi: 10.1097/RLU.0000000000003962. PMID: 34874348
Artificial Intelligence in Vascular-PET:: Translational and Clinical Applications. Paravastu SS, Theng EH, Morris MA, Grayson P, Collins MT, Maass-Moreno R, Piri R, Gerke O, Alavi A, Flemming Høilund-Carlsen P, Edenbrandt L, Saboury B. PET Clin. 2022 Jan;17(1):95-113. doi: 10.1016/j.cpet.2021.09.003. PMID: 34809874
CAR T cells produced in vivo to treat cardiac injury. Rurik JG, Tombácz I, Yadegari A, Méndez Fernández PO, Shewale SV, Li L, Kimura T, Soliman OY, Papp TE, Tam YK, Mui BL, Albelda SM, Puré E, June CH, Aghajanian H, Weissman D, Parhiz H, Epstein JA. Science. 2022 Jan 7;375(6576):91-96. doi: 10.1126/science.abm0594. Epub 2022 Jan 6. PMID: 34990237
A novel assay to isolate and quantify third-stage Dirofilaria immitis and Brugia malayi larvae emerging from individual Aedes aegypti. McCrea AR, Edgerton EB, Oliver GT, O'Neill FM, Nolan TJ, Lok JB, Povelones M. Parasit Vectors. 2021 Jan 7;14(1):30. doi: 10.1186/s13071-020-04529-w. PMID: 33413579
Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory. Morrison TA, Hudson WH, Chisolm DA, Kanno Y, Shih HY, Ahmed R, Henao-Mejia J, Hafner M, O'Shea JJ. Cold Spring Harb Perspect Biol. 2022 Jan 4;14(1):a037952. doi: 10.1101/cshperspect.a037952. PMID: 34001528
Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity. Bais S, Norwillo A, Ruthel G, Herbert DR, Freedman BD, Greenberg RM. Biochimie. 2022 Jan 3:S0300-9084(21)00306-0. doi: 10.1016/j.biochi.2021.12.018. Online ahead of print. PMID: 34990770
Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells. Chaki S, Alkanfari I, Roy S, Amponnawarat A, Hui Y, Oskeritzian CA, Ali H. Front Immunol. 2022 Jan 20;12:803335. doi: 10.3389/fimmu.2021.803335. eCollection 2021. PMID: 35126366
Insights Into the Emergence of Paroxysmal Nocturnal Hemoglobinuria. Colden MA, Kumar S, Munkhbileg B, Babushok DV. Front Immunol. 2022 Jan 28;12:830172. doi: 10.3389/fimmu.2021.830172. eCollection 2021. PMID: 35154088
Eltrombopag: a springboard to early responses in SAA. Babushok DV. Blood. 2022 Jan 6;139(1):1-2. doi: 10.1182/blood.2021014046. PMID: 34989776
Nemo-Dependent, ATM-Mediated Signals from RAG DNA Breaks at IgkFeedback Inhibit V κ Recombination to Enforce Igκ Allelic Exclusion. Glynn RA, Bassing CH. J Immunol. 2022 Jan 15;208(2):371-383. doi: 10.4049/jimmunol.2100696. Epub 2021 Dec 29. PMID: 34965965
Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+biosynthesis and sustain cardiac function. Dierickx P, Zhu K, Carpenter BJ, Jiang C, Vermunt MW, Xiao Y, Luongo TS, Yamamoto T, Martí-Pàmies Í, Mia S, Latimer M, Diwan A, Zhao J, Hauck AK, Krusen B, Nguyen HCB, Blobel GA, Kelly DP, Pei L, Baur JA, Young ME, Lazar MA. Nat Cardiovasc Res. 2022 Jan;1(1):45-58. doi: 10.1038/s44161-021-00001-9. Epub 2021 Dec 23. PMID: 35036997
Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication. Naseer N, Egan MS, Reyes Ruiz VM, Scott WP, Hunter EN, Demissie T, Rauch I, Brodsky IE, Shin S. PLoS Pathog. 2022 Jan 24;18(1):e1009718. doi: 10.1371/journal.ppat.1009718. eCollection 2022 Jan. PMID: 35073381
Reduced-Intensity/Reduced-Toxicity Conditioning Approaches Are Tolerated in XIAP Deficiency but Patients Fare Poorly with Acute GVHD. Arnold DE, Nofal R, Wakefield C, Lehmberg K, Wustrau K, Albert MH, Morris EC, Heimall JR, Bunin NJ, Kumar A, Jordan MB, Cole T, Choo S, Brettig T, Speckmann C, Ehl S, Salamonowicz M, Wahlstrom J, Rao K, Booth C, Worth A, Marsh RA. J Clin Immunol. 2022 Jan;42(1):36-45. doi: 10.1007/s10875-021-01103-6. Epub 2021 Sep 29. PMID: 34586554
Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott-Aldrich syndrome. Magnani A, Semeraro M, Adam F, Booth C, Dupré L, Morris EC, Gabrion A, Roudaut C, Borgel D, Toubert A, Clave E, Abdo C, Gorochov G, Petermann R, Guiot M, Miyara M, Moshous D, Magrin E, Denis A, Suarez F, Lagresle C, Roche AM, Everett J, Trinquand A, Guisset M, Bayford JX, Hacein-Bey-Abina S, Kauskot A, Elfeky R, Rivat C, Abbas S, Gaspar HB, Macintyre E, Picard C, Bushman FD, Galy A, Fischer A, Six E, Thrasher AJ, Cavazzana M. Nat Med. 2022 Jan;28(1):71-80. doi: 10.1038/s41591-021-01641-x. Epub 2022 Jan 24. PMID: 35075289
Radiomic Phenotypes for Improving Early Prediction of Survival in Stage III Non-Small Cell Lung Cancer Adenocarcinoma after Chemoradiation. Luna JM, Barsky AR, Shinohara RT, Roshkovan L, Hershman M, Dreyfuss AD, Horng H, Lou C, Noël PB, Cengel KA, Katz S, Diffenderfer ES, Kontos D. Cancers (Basel). 2022 Jan 29;14(3):700. doi: 10.3390/cancers14030700. PMID: 35158971
Mesenchymal stromal cells enhance self-assembly of a HUVEC tubular network through uPA-uPAR/VEGFR2/integrin/NOTCH crosstalk. Beloglazova I, Stepanova V, Zubkova E, Dergilev K, Koptelova N, Tyurin-Kuzmin PA, Dyikanov D, Plekhanova O, Cines DB, Mazar AP, Parfyonova Y. Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119157. doi: 10.1016/j.bbamcr.2021.119157. Epub 2021 Oct 4. PMID: 34619163
Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle. Huang Y, Hsu JC, Koo H, Cormode DP. Theranostics. 2022 Jan 1;12(2):796-816. doi: 10.7150/thno.67375. eCollection 2022. PMID: 34976214
PBJ celebrates twenty years of service to the scientific community by offering free global access, improved ranking and diversity. Daniell H. Plant Biotechnol J. 2022 Jan;20(1):3-9. doi: 10.1111/pbi.13757. PMID: 34957690
Mining for encrypted peptide antibiotics in the human proteome. Torres MDT, Melo MCR, Crescenzi O, Notomista E, de la Fuente-Nunez C. Nat Biomed Eng. 2022 Jan;6(1):67-75. doi: 10.1038/s41551-021-00801-1. Epub 2021 Nov 4. PMID: 34737399
A Randomized Phase II Study of Nivolumab Monotherapy or Nivolumab Combined with Ipilimumab in Patients with Advanced Gastrointestinal Stromal Tumors. Singh AS, Hecht JR, Rosen L, Wainberg ZA, Wang X, Douek M, Hagopian A, Andes R, Sauer L, Brackert SR, Chow W, DeMatteo R, Eilber FC, Glaspy JA, Chmielowski B. Clin Cancer Res. 2022 Jan 1;28(1):84-94. doi: 10.1158/1078-0432.CCR-21-0878. Epub 2021 Aug 18. PMID: 34407970
Regulation of the BCR signalosome by the class II peptide editor, H2-M, affects the development and repertoire of innate-like B cells. Ghosh D, Pham TD, Nanaware PP, Sengupta D, Adler LN, Li CG, He X, O'Mara ME, Kantor AB, Nguyen KD, Yang Y, Eisenlohr LC, Jensen PE, Herzenberg LA, Stern LJ, Boyd SD, Ghosn EEB, Mellins ED. Cell Rep. 2022 Jan 25;38(4):110200. doi: 10.1016/j.celrep.2021.110200. PMID: 35081339
Does biologic therapy impact the development of PsA among patients with psoriasis? Meer E, Merola JF, Fitzsimmons R, Love TJ, Wang S, Shin D, Chen Y, Xie S, Choi H, Zhang Y, Scher JU, Ritchlin CT, Gelfand JM, Ogdie A. Ann Rheum Dis. 2022 Jan;81(1):80-86. doi: 10.1136/annrheumdis-2021-220761. Epub 2021 Oct 6. PMID: 34615637
Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants. Groß R, Zanoni M, Seidel A, Conzelmann C, Gilg A, Krnavek D, Erdemci-Evin S, Mayer B, Hoffmann M, Pöhlmann S, Liu W, Hahn BH, Beil A, Kroschel J, Jahrsdörfer B, Schrezenmeier H, Kirchhoff F, Münch J, Müller JA .EBioMedicine. 2022 Jan;75:103761. doi: 10.1016/j.ebiom.2021.103761. Epub 2021 Dec 17. PMID: 34929493
Frontiers in Oral Mucosal Immunity and the Microbiome. Belibasakis GN, Hajishengallis G. Front Oral Health. 2022 Jan 3;2:821148. doi: 10.3389/froh.2021.821148. eCollection 2021. PMID: 35048081
Artificial Intelligence-based Tumor Segmentation in Mouse Models of Lung Adenocarcinoma. Arlova A, Jin C, Wong-Rolle A, Chen ES, Lisle C, Brown GT, Lay N, Choyke PL, Turkbey B, Harmon S, Zhao C. J Pathol Inform. 2022 Jan 20;13:100007. doi: 10.1016/j.jpi.2022.100007. eCollection 2022. PMID: 35242446
Kinetic dissection of macromolecular complex formation with minimally perturbing fluorescent probes. Cory MB, Hostetler ZM, Kohli RM. Methods Enzymol. 2022;664:151-171. doi: 10.1016/bs.mie.2022.01.009. Epub 2022 Jan 29. PMID: 35331372
The Rapid Implementation of Ad Hoc Tele-Critical Care Respiratory Therapy (eRT) Service in the Wake of the COVID-19 Surge. Pierce M, Gudowski SW, Roberts KJ, Jackominic A, Zumstein KK, Shuttleworth A, Ho J, Susser P, Parikh A, Chandler JM, Huffenberger AM, Scott MJ, Hanson CW 3rd, Laudanski K. J Clin Med. 2022 Jan 29;11(3):718. doi: 10.3390/jcm11030718. PMID: 35160170
Considerations for Cannabinoids in Perioperative Care by Anesthesiologists. Laudanski K, Wain J. J Clin Med. 2022 Jan 22;11(3):558. doi: 10.3390/jcm11030558. PMID: 35160010
A review of signaling and transcriptional control in T follicular helper cell differentiation. Hart AP, Laufer TM. J Leukoc Biol. 2022 Jan;111(1):173-195. doi: 10.1002/JLB.1RI0121-066R. Epub 2021 Apr 18. PMID: 33866600
FZD2 Regulates Murine Hair Follicle Function and Maintenance. Brennan-Crispi DM, Frankfurter M, Murphy C, Sheng E, Xu M, Morrisey EE, Millar SE, Leung TH .J Invest Dermatol. 2022 Jan 17:S0022-202X(22)00011-2. doi: 10.1016/j.jid.2022.01.004. Online ahead of print. PMID: 35051380
A Murine Model of X-Linked Moesin-Associated Immunodeficiency (X-MAID) Reveals Defects in T Cell Homeostasis and Migration. Avery L, Robertson TF, Wu CF, Roy NH, Chauvin SD, Perkey E, Vanderbeck A, Maillard I, Burkhardt JK. Front Immunol. 2022 Jan 6;12:726406. doi: 10.3389/fimmu.2021.726406. eCollection 2021. PMID: 35069520
Patient Perceptions and Preferences Regarding Telemedicine for Autoimmune Rheumatic Diseases Care During the COVID-19 Pandemic. Danila MI, Gavigan K, Rivera E, Nowell WB, George MD, Curtis JR, Christopher-Stein L, Banerjee S, Merkel PA, Young K, Shaw DG, Gordon J, Venkatachalam S. Arthritis Care Res (Hoboken). 2022 Jan 18:10.1002/acr.24860. doi: 10.1002/acr.24860. Online ahead of print. PMID: 35040274
Use of 18F-fluorodeoxyglucose Positron Emission Tomography to Standardize Clinical Trial Recruitment in Takayasu's Arteritis. Quinn KA, Alessi H, Ponte C, Rose E, Ahlman MA, Redmond C, Luo Y, Bolek EC, Langford CA, Merkel PA, Grayson PC. Rheumatology (Oxford). 2022 Jan 12:keac021. doi: 10.1093/rheumatology/keac021. Online ahead of print. PMID: 35022691
The Minority Scientists' Experience: Challenging and Overcoming Barriers to Enhancing Diversity and Career Advancement. Webb TJ, Guerau-de-Arellano M, Jones HP, Butts CL, Sanchez-Perez L, Montaner LJ. J Immunol. 2022 Jan 15;208(2):197-202. doi: 10.4049/jimmunol.2101077. PMID: 35017208
Uncommon variants in FLG2 and TCHHL1 are associated with remission of atopic dermatitis in a large longitudinal US cohort. Berna R, Mitra N, Hoffstad O, Wubbenhorst B, Nathanson KL, Margolis D J.Arch Dermatol Res. 2022 Jan 4. doi: 10.1007/s00403-021-02319-7. Online ahead of print. PMID: 34984527
Sweet Immune Checkpoint Targets to Enhance T Cell Therapy. Derosiers N, Aguilar W, DeGaramo DA, Posey AD Jr. J Immunol. 2022 Jan 15;208(2):278-285. doi: 10.4049/jimmunol.2100706. PMID: 35017217
Dermatologic Events Associated with the Anti-CCR4 Antibody Mogamulizumab: Characterization and Management. Musiek ACM, Rieger KE, Bagot M, Choi JN, Fisher DC, Guitart J, Haun PL, Horwitz SM, Huen AO, Kwong BY, Lacouture ME, Noor SJ, Rook AH, Seminario-Vidal L, Vermeer MH, Kim YH .Dermatol Ther (Heidelb). 2022 Jan;12(1):29-40. doi: 10.1007/s13555-021-00624-7. Epub 2021 Nov 23. PMID: 34816383
CD73+ Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis. Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB. Cell Mol Gastroenterol Hepatol. 2022;13(5):1449-1467. doi: 10.1016/j.jcmgh.2022.01.018. Epub 2022 Jan 30. PMID: 35108658
Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys. Pegu A, Xu L, DeMouth ME, Fabozzi G, March K, Almasri CG, Cully MD, Wang K, Yang ES, Dias J, Fennessey CM, Hataye J, Wei RR, Rao E, Casazza JP, Promsote W, Asokan M, McKee K, Schmidt SD, Chen X, Liu C, Shi W, Geng H, Foulds KE, Kao SF, Noe A, Li H, Shaw GM, Zhou T, Petrovas C, Todd JP, Keele BF, Lifson JD, Doria-Rose NA, Koup RA, Yang ZY, Nabel GJ, Mascola JR. Cell Rep. 2022 Jan 4;38(1):110199. doi: 10.1016/j.celrep.2021.110199. PMID: 34986348
Efficacy and safety of a novel mucoadhesive clobetasol patch for treatment of erosive oral lichen planus: A phase 2 randomized clinical trial. Brennan MT, Madsen LS, Saunders DP, Napenas JJ, McCreary C, Ni Riordain R, Pedersen AML, Fedele S, Cook RJ, Abdelsayed R, Llopiz MT, Sankar V, Ryan K, Culton DA, Akhlef Y, Castillo F, Fernandez I, Jurge S, Kerr AR, McDuffie C, McGaw T, Mighell A, Sollecito TP, Schlieve T, Carrozzo M, Papas A, Bengtsson T, Al-Hashimi I, Burke L, Burkhart NW, Culshaw S, Desai B, Hansen J, Jensen P, Menné T, Patel PB, Thornhill M, Treister N, Ruzicka T. J Oral Pathol Med. 2022 Jan;51(1):86-97. doi: 10.1111/jop.13270. Epub 2022 Jan 13. PMID: 34907617
Numbers and narratives: how qualitative methods can strengthen the science of paediatric antimicrobial stewardship. Woods-Hill CZ, Xie A, Lin J, Wolfe HA, Plattner AS, Malone S, Chiotos K, Szymczak JE .JAC Antimicrob Resist. 2022 Jan 22;4(1):dlab195. doi: 10.1093/jacamr/dlab195. eCollection 2022 Mar. PMID: 35098126
SARS-CoV-2 DNA Vaccine INO-4800 Induces Durable Immune Responses Capable of Being Boosted in a Phase 1 Open-Label Trial. Kraynyak KA, Blackwood E, Agnes J, Tebas P, Giffear M, Amante D, Reuschel EL, Purwar M, Christensen-Quick A, Liu N, Andrade VM, Diehl MC, Wani S, Lupicka M, Sylvester A, Morrow MP, Pezzoli P, McMullan T, Kulkarni AJ, Zaidi FI, Frase D, Liaw K, Smith TRF, Ramos SJ, Ervin J, Adams M, Lee J, Dallas M, Brown AS, Shea JE, Kim JJ, Weiner DB, Broderick KE, Humeau LM, Boyer JD, Mammen MP.J Infect Dis. 2022 Jan 25:jiac016. doi: 10.1093/infdis/jiac016. Online ahead of print.PMID: 35079784
Association of Convalescent Plasma Treatment With Clinical Status in Patients Hospitalized With COVID-19: A Meta-analysis. Troxel AB, Petkova E, Goldfeld K, Liu M, Tarpey T, Wu Y, Wu D, Agarwal A, Avendaño-Solá C, Bainbridge E, Bar KJ, Devos T, Duarte RF, Gharbharan A, Hsue PY, Kumar G, Luetkemeyer AF, Meyfroidt G, Nicola AM, Mukherjee A, Ortigoza MB, Pirofski LA, Rijnders BJA, Rokx C, Sancho-Lopez A, Shaw P, Tebas P, Yoon HA, Grudzen C, Hochman J, Antman EM. JAMA Netw Open. 2022 Jan 4;5(1):e2147331. doi: 10.1001/jamanetworkopen.2021.47331. PMID: 35076699
Automatic upper airway segmentation in static and dynamic MRI via anatomy-guided convolutional neural networks. Xie L, Udupa JK, Tong Y, Torigian DA, Huang Z, Kogan RM, Wootton D, Choy KR, Sin S, Wagshul ME, Arens R. Med Phys. 2022 Jan;49(1):324-342. doi: 10.1002/mp.15345. Epub 2021 Dec 2. PMID: 34773260
Rapid Production of Bispecific Antibodies from Off-the-Shelf IgGs with High Yield and Purity. Mei L, Zappala F, Tsourkas A. Bioconjug Chem. 2022 Jan 19;33(1):134-141. doi: 10.1021/acs.bioconjchem.1c00476. Epub 2021 Dec 12. PMID: 34894663
Evolution of FMT - From early clinical to standardized treatments. Servetas SL, Daschner PJ, Guyard C, Thomas V, Affagard H, Sergaki C, Sokol H, Wargo JA, Wu GD, Sabot P. Biologicals. 2022 Jan 24:S1045-1056(22)00004-5. doi: 10.1016/j.biologicals.2022.01.004. Online ahead of print. PMID: 35086768
Causes of readmissions for patients discharged on enteral nutrition. Palchaudhuri S, Mehta SJ, Snider CK, Parsikia A, Hudson L, Compher C, Lewis JD, Wu GD, Pickett-Blakely O. JPEN J Parenter Enteral Nutr. 2022 Jan 18. doi: 10.1002/jpen.2331. Online ahead of print. PMID: 35040141

2021

December 2021

Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children With Sepsis. Weiss SL, Henrickson SE, Lindell RB, Sartori LF, Zhang D, Bush J, Farooqi S, Starr J, Deutschman CS, McGowan FX Jr, Becker L, Tuluc F, Wherry EJ, Picard M, Wallace DC. Shock. 2021 Dec 28. doi: 10.1097/SHK.0000000000001903. Online ahead of print. PMID: 34966070
BLyS neutralization results in selective anti-HLA alloantibody depletion without successful desensitization. Agarwal D, Luning Prak ET, Bharani T, Everly M, Migone TS, Cancro M, Allman D, Choe I, Kearns JD, Trofe-Clark J, Naji A, Kamoun M. Transpl Immunol. 2021 Dec;69:101465. PMID: 34506905
The evolution of the ISHLT transplant registry. Preparing for the future. Stehlik J, Christie JD, Goldstein DR, Amarelli C, Bertolotti A, Chambers DC, Dorent R, Gonzalez-Vilchez F, Parameshwar J, Perch M, Zuckermann A, Coll E, Levy RD, Atik FA, Gomez-Mesa JE, Moayedi Y, Peled-Potashnik Y, Schultz G, Cherikh W, Danziger-Isakov L. J Heart Lung Transplant. 2021 Dec;40(12):1670-1681. PMID: 34657795
Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrel A, Lambert MP, Sullivan KE, Wherry EJ, Teachey DT, Bassiri H, Behrens EM. Nature Comunications. 2021 Dec 10;12(1):7222. PMID: 34893640
Pain killers: the interplay between nonsteroidal anti-inflammatory drugs and Clostridioides difficile infection. Soto Ocaña J, Bayard NU, Zackular JP. Curr Opin Microbiol. 2021 Dec 8;65:167-174. PMID: 34894543
Global Microbiota-Dependent Histone Acetylation Patterns Are Irreversible and Independent of Short Chain Fatty Acids. Saiman Y, Shen TD, Lund PJ, Gershuni VM, Jang C, Patel S, Jung S, Furth EE, Friedman ES, Chau L, Garcia BA, Wu GD. Hepatology. 2021 Dec;74(6):3427-3440. PMID: 34233020
Local tissue heterogeneity may modulate neuronal responses via altered axon strain fields: insights about innervated joint capsules from a computational model. Middendorf JM, Ita ME, Winkelstein BA, H Barocas V. Biomech Model Mechanobiol. 2021 Dec;20(6):2269-2285. PMID: 34514531
American College of Rheumatology White Paper on Antimalarial Cardiac Toxicity. Desmarais J, Rosenbaum JT, Costenbader KH, Ginzler EM, Fett N, Goodman S, O'Dell J, Pineau CA, Schmajuk G, Werth VP, Link MS, Kovacs R. Arthritis Rheumatol. 2021 Dec;73(12):2151-2160. PMID: 34697918

November 2021

Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination. Kahn B, Apostolidis SA, Bhatt V, Greenplate AR, Kallish S, LaCava A, Lucas A, Meyer NJ, Negoianu D, Ogdie AR, Shashaty MGS, Takach PA, Zuroff L, Wherry EJ, Anesi GL. Crit Care Explor. 2021 Nov 5;3(11):e0578. doi: 10.1097/CCE.0000000000000578. PMID: 34765984.
Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Nat Immunol. 2021 Nov;22(11):1465. PMID: 34588688
A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia. Bar KJ, Shaw PA, Choi GH, Aqui N, Fesnak A, Yang JB, Soto-Calderon H, Grajales L, Starr J, Andronov M, Mastellone M, Amonu C, Feret G, DeMarshall M, Buchanan M, Caturla M, Gordon J, Wanicur A, Monroy MA, Mampe F, Lindemuth E, Gouma S, Mullin AM, Barilla H, Pronina A, Irwin L, Thomas R, Eichinger RA, Demuth F, Luning Prak ET, Pascual JL, Short WR, Elovitz MA, Baron J, Meyer NJ, Degnan KO, Frank I, Hensley SE, Siegel DL, Tebas P. J Clin Invest. 2021 Nov 17:e155114. PMID: 34788233
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Apostolidis SA, Kakara M, Painter MM, Goel RR, Mathew D, Lenzi K, Rezk A, Patterson KR, Espinoza DA, Kadri JC, Markowitz DM, E Markowitz C, Mexhitaj I, Jacobs D, Babb A, Betts MR, Prak ETL, Weiskopf D, Grifoni A, Lundgreen KA, Gouma S, Sette A, Bates P, Hensley SE, Greenplate AR, Wherry EJ, Li R, Bar-Or A. Nat Med. 2021 Nov;27(11):1990-2001PMID: 34522051
Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells. Adeniji OS, Kuri-Cervantes L, Yu C, Xu Z, Ho M, Chew GM, Shikuma C, Tomescu C, George AF, Roan NR, Ndhlovu LC, Liu Q, Muthumani K, Weiner DB, Betts MR, Xiao H, Abdel-Mohsen M. PLoS Pathog. 2021 Nov 11;17(11):e1010034. PMID: 34762717
MELD-based allocation at 20: Can we evolve and mature? Bittermann T, Abt PL. Am J Transplant. 2021 Nov;21(11):3511-3512. PMID: 34375509
Diagnosis of bone metastases in breast cancer: Lesion-based sensitivity of dual-time-point FDG-PET/CT compared to low-dose CT and bone scintigraphy. Hansen JA, Naghavi-Behzad M, Gerke O, Baun C, Falch K, Duvnjak S, Alavi A, Høilund-Carlsen PF, Hildebrandt MG. PLoS One. 2021 Nov 18;16(11):e0260066. PMID: 34793550 PMCID: PMC8601566
Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments. McCorkell KA, Jayachandran N, Cully MD, Freund-Brown J, Weinkopff T, Monslow J, Hu Y, Puré E, Freedman BD, Alvarez JI, Cancro MP, May MJ. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2100195118. PMID: 34810256
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Alameh MG, Tombácz I, Bettini E, Lederer K, Sittplangkoon C, Wilmore JR, Gaudette BT, Soliman OY, Pine M, Hicks P, Manzoni TB, Knox JJ, Johnson JL, Laczkó D, Muramatsu H, Davis B, Meng W, Rosenfeld AM, Strohmeier S, Lin PJC, Mui BL, Tam YK, Karikó K, Jacquet A, Krammer F, Bates P, Cancro MP, Weissman D, Luning Prak ET, Allman D, Locci M, Pardi N. Immunity. 2021 Nov 4:S1074-7613(21)00490-8. PMID: 34852217 PMCID: PMC8566475
Clostridioides difficile and the Microbiota Early in Life. Semon AK, Keenan O, Zackular JP. J Pediatric Infect Dis Soc. 2021 Nov 17;10(Supplement_3):S3-S7. PMID: 34791400 PMCID: PMC8600012
Clostridioides difficile Infection in Children: Research Progress, Pitfalls, and Priorities. Kociolek LK, Burnham CD, Nicholson MR, Zackular JP. J Pediatric Infect Dis Soc. 2021 Nov 17;10(Supplement_3):S1-S2. PMID: 34791394
Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations. Kociolek LK, Zackular JP, Savidge T. J Pediatric Infect Dis Soc. 2021 Nov 17;10(Supplement_3):S8-S15. PMID: 34791392 PMCID: PMC8600028
SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens. Bartolo L, Afroz S, Pan YG, Xu R, Williams L, Lin CF, Friedman ES, Gimotty PA, Wu GD, Su LF. bioRxiv. 2021 Nov 30:2021.11.29.470421. PMID: 34873598 PMCID: PMC8647649
Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome. Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD. Gastroenterology. 2021 Nov 10:S0016-5085(21)03728-8. PMID: 34774538
Role of CXCL5 in Regulating Chemotaxis of Innate and Adaptive Leukocytes in Infected Lungs Upon Pulmonary Influenza Infection. Guo L, Li N, Yang Z, Li H, Zheng H, Yang J, Chen Y, Zhao X, Mei J, Shi H, Worthen GS, Liu L. Front Immunol. 2021 Nov 18;12:785457. PMID: 34868067
Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Myerson JW, Patel PN, Rubey KM, Zamora ME, Zaleski MH, Habibi N, Walsh LR, Lee YW, Luther DC, Ferguson LT, Marcos-Contreras OA, Glassman PM, Mazaleuskaya LL, Johnston I, Hood ED, Shuvaeva T, Wu J, Zhang HY, Gregory JV, Kiseleva RY, Nong J, Grosser T, Greineder CF, Mitragotri S, Worthen GS, Rotello VM, Lahann J, Muzykantov VR, Brenner JS. Nat Nanotechnol. 2021 Nov 18. doi: 10.1038/s41565-021-00997-y. PMID: 34795440
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits. Pahl MC, Doege CA, Hodge KM, Littleton SH, Leonard ME, Lu S, Rausch R, Pippin JA, De Rosa MC, Basak A, Bradfield JP, Hammond RK, Boehm K, Berkowitz RI, Lasconi C, Su C, Chesi A, Johnson ME, Wells AD, Voight BF, Leibel RL, Cousminer DL, Grant SFA. Nat Commun. 2021 Nov 19;12(1):6749. PMID: 34799566

October 2021

The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination. Beilinson HA, Glynn RA, Yadavalli AD, Xiao J, Corbett E, Saribasak H, Arya R, Miot C, Bhattacharyya A, Jones JM, Pongubala JMR, Bassing CH, Schatz DG .J Exp Med. 2021 Oct 4;218(10):e20210250. doi: 10.1084/jem.20210250. Epub 2021 Aug 17. PMID: 34402853
Non-invasive imaging for the diagnosis of acute rejection in transplantation: The next frontier. Matar AJ, Crepeau RL, Duran-Struuck R. Transpl Immunol. 2021 Oct;68:101431. doi: 10.1016/j.trim.2021.101431. Epub 2021 Jun 19. PMID: 34157374
A Cre-driven allele-conditioning line to interrogate CD4 + conventional T cells. Andrews LP, Vignali KM, Szymczak-Workman AL, Burton AR, Brunazzi EA, Ngiow SF, Harusato A, Sharpe AH, Wherry EJ, Taniuchi I, Workman CJ, Vignali DAA. Immunity. 2021 Oct 12;54(10):2209-2217.e6. doi: 10.1016/j.immuni.2021.08.029. Epub 2021 Sep 21. PMID: 34551314
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ, Adamski S, Alam Z, Addison MM, Byrne KT, Chandra A, Descamps HC, Han N, Kaminskiy Y, Kammerman SC, Kim J, Greenplate AR, Hamilton JT, Markosyan N, Noll JH, Omran DK, Pattekar A, Perkey E, Prager EM, Pueschl D, Rennels A, Shah JB, Shilan JS, Wilhausen N, Vanderbeck AN. Science. 2021 Oct 14;eabm0829. PMID: 34648302
Corrigendum: Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients. Corrigendum: Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients. Giron LB, Dweep H, Yin X, Wang H, Damra M, Goldman AR, Gorman N, Palmer CS, Tang HY, Shaikh MW, Forsyth CB, Balk RA, Zilberstein NF, Liu Q, Kossenkov A, Keshavarzian A, Landay A, Abdel-Mohsen M. Front Immunol. 2021 Oct 4;12:779064. PMID: 34671365
Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model. Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model. Patel A, Walters JN, Reuschel EL, Schultheis K, Parzych E, Gary EN, Maricic I, Purwar M, Eblimit Z, Walker SN, Guimet D, Bhojnagarwala P, Adeniji OS, Doan A, Xu Z, Elwood D, Reeder SM, Pessaint L, Kim KY, Cook A, Chokkalingam N, Finneyfrock B, Tello-Ruiz E, Dodson A, Choi J, Generotti A, Harrison J, Tursi NJ, Andrade VM, Dia Y, Zaidi FI, Andersen H, Abdel-Mohsen M, Lewis MG, Muthumani K, Kim JJ, Kulp DW, Humeau LM, Ramos SJ, Smith TRF, Weiner DB, Broderick KE. Cell Rep Med. 2021 Oct 19;2(10):100420. PMID: 34604818 PMCID: PMC8479327
Thromboelastography profiles for controlled circulatory death donors: Validating the role of heparin. Crannell WC, Sally M, McConnell K, Connelly C, Maynard E, Dewey E, Abt P, Enestvedt CK. Clin Transplant. 2021 Oct 19:e14518. PMID: 34668240
A pragmatic outreach pilot to understand and overcome barriers to COVID-19 vaccination in abdominal organ transplant. Serper M, Liu CH, Blumberg EA, Burdzy AE, Veasey S, Halpern S, Lander E, Sigafus MR, Bloom RD, Dunn TB, Abt PL, Reddy KR, Mehta SJ. Transpl Infect Dis. 2021 Oct;23(5):e13722. PMID: 34496115
Implementation of FDG-PET/CT imaging methodology for quantification of inflammatory response in patients with locally advanced non-small cell lung cancer: results from the ACRIN 6668/RTOG 0235 trial. Jahangiri P, Dreyfuss AD, Duan F, Snyder BS, Borja AJ, Pournazari K, Kothekar E, Arani L, Al-Zaghal A, Seraj SM, Hancin EC, Pinheiro B, Werner TJ, Swisher-McClure S, Feigenberg SJ, Torigian DA, Revheim ME, Simone CB 2nd, Alavi A. 2021 Oct 15;11(5):415-427. PMID: 34754612
Tau-PET imaging as a molecular modality for Alzheimer's disease. Ayubcha C, Rigney G, Borja AJ, Werner T, Alavi A. Am J Nucl Med Mol Imaging. 2021 Oct 15;11(5):374-386. PMID: 34754608 PMCID: PMC8569333
Critical review of PET imaging for detection and characterization of the atherosclerotic plaques with emphasis on limitations of FDG-PET compared to NaF-PET in this setting. Alavi A, Werner TJ, Raynor W, Høilund-Carlsen PF, Revheim ME. Am J Nucl Med Mol Imaging. 2021 Oct 15;11(5):337-351. PMID: 34754605 PMCID: PMC8569336
Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models. Awasthi S, Knox JJ, Desmond A, Alameh MG, Gaudette BT, Lubinski JM, Naughton A, Hook LM, Egan KP, Tam YK, Pardi N, Allman D, Luning Prak ET, Cancro MP, Weissman D, Cohen GH, Friedman HM. J Clin Invest. 2021 Oct 7:e152310. PMID: 34618692
Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation. Gaudette BT, Roman CJ, Ochoa TA, Gómez Atria D, Jones DD, Siebel CW, Maillard I, Allman D. J Clin Invest. 2021 Oct 15;131(20):e151975. PMID: 34473651 PMCID: PMC8516456
Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection. Bjanes E, Sillas RG, Matsuda R, Demarco B, Fettrelet T, DeLaney AA, Kornfeld OS, Lee BL, Rodríguez López EM, Grubaugh D, Wynosky-Dolfi MA, Philip NH, Krespan E, Tovar D, Joannas L, Beiting DP, Henao-Mejia J, Schaefer BC, Chen KW, Broz P, Brodsky IE. PLoS Pathog. 2021 Oct 14;17(10):e1009967. PMID: 34648590
Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis. Sivakumar P, Ammar R, Thompson JR, Luo Y, Streltsov D, Porteous M, McCoubrey C, Cantu E 3rd, Beers MF, Jarai G, Christie JD. Respir Res. 2021 Oct 24;22(1):273. PMID: 34689792 PMCID: PMC8543878
Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments. Bhatta M, Shenoy GN, Loyall JL, Gray BD, Bapardekar M, Conway A, Minderman H, Kelleher RJ Jr, Carreno BM, Linette G, Shultz LD, Odunsi K, Balu-Iyer SV, Pak KY, Bankert RB. J Immunother Cancer. 2021 Oct;9(10):e003148. PMID: 34599030 PMCID: PMC8488709
Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort. Shah S, Halvorson A, McBay B, Dorn C, Wilson O, Tuteja S, Chang KM, Cho K, Hauger R, Suzuki A, Hunt C, Siew E, Matheny M, Hung A, Greevy R, Roumie C. Gut. 2021 Oct 18:gutjnl-2021-325701. PMID: 34663578
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. Verma A, Tsao NL, Thomann L, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford D, Efird JT, Huffman J, Hung A, Ivey KL, Levin M, Lynch J, Natarajan P, Pyarajan S, Bick A, Costa L, Genovese G, Hauger R, Madduri R, Pathak GA, Polimanti R, Voight B, Vujkovic M, Zekavat M, Zhao H, Ritchie MD; VA Million Veteran Program COVID-19 Science Initiative, Chang KM, Cho K, Casas JP, Tsao PS, Gaziano JM, O'Donnell C, Damrauer SM, Liao KP. medRxiv. 2021 Oct 6:2021.05.18.21257396. PMID: 34642702 PMCID: PMC8509103
A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease. Levin MG, Klarin D, Georgakis MK, Lynch J, Liao KP, Voight BF, O'Donnell CJ, Chang KM, Assimes TL, Tsao PS, Damrauer SM; VA Million Veteran Program. Circ Res. 2021 Oct 29;129(10):968-970. PMID: 34547901 PMCID: PMC8556352
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. Liu X, Verma A, Garcia G Jr, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2113401118. PMID: 34593624 PMCID: PMC8594528
Early post-lung transplant calcineurin inhibitor management varies widely: An international survey. Farrell CL, Miano TA, Griffiths S, Christie JD, Diamond JM, Shashaty MGS. Clin Transplant. 2021 Oct 13:e14510. PMID: 34643962
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia. Lam LKM, Murphy S, Kokkinaki D, Venosa A, Sherrill-Mix S, Casu C, Rivella S, Weiner A, Park J, Shin S, Vaughan AE, Hahn BH, Odom John AR, Meyer NJ, Hunter CA, Worthen GS, Mangalmurti NS. Sci Transl Med. 2021 Oct 20;13(616):eabj1008. PMID: 34669439

September 2021

The special unfolded protein response in plasma cells. Ricci D, Gidalevitz T, Argon Y. Immunol Rev. 2021 Sep;303(1):35-51. doi: 10.1111/imr.13012. Epub 2021 Aug 8 PMID: 34368957
Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial. Reich DS, Arnold DL, Vermersch P, Bar-Or A, Fox RJ, Matta A, Turner T, Wallström E, Zhang X, Mareš M, Khabirov FA, Traboulsee A; Tolebrutinib Phase 2b Study Group. Lancet Neurol. 2021 Sep;20(9):729-738. PMID: 34418400
Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, Kleinhenz ME, Golden JA, Sutter N, Tietje-Ulrich G, Criner RN, Arcasoy SM, Christie JD, Diamond J, Singer JP. Ann Am Thorac Soc. 2021 Sep;18(9):1464-1474. doi: 10.1513/AnnalsATS.202007-796OC. PMID: 33565917
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency. Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. PMID: 34358447
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates . Zabaleta N, Dai W, Bhatt U, Hérate C, Maisonnasse P, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Naninck T, Kahlaoui N, Lemaitre J, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Contreras V, Marlin R, Tsong Fang RH, Chapon C, van der Werf S, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Le Grand R, Vandenberghe LH. Cell Host Microbe. 2021 Sep 8;29(9):1437-1453.e8. doi: 10.1016/j.chom.2021.08.002. Epub 2021 Aug 7. PMID: 34428428
The mechanisms of smell loss after SARS-CoV-2 infection. Doty RL. Lancet Neurol. 2021 Sep;20(9):693-695. PMID: 34339627 PMCID: PMC8324112
A pragmatic outreach pilot to understand and overcome barriers to COVID-19 vaccination in abdominal organ transplant. Serper M, Liu CH, Blumberg EA, Burdzy AE, Veasey S, Halpern S, Lander E, Sigafus M, Bloom RD, Dunn T, Abt P, Reddy KR, Mehta SJ. Transpl Infect Dis. 2021 Sep 8. doi: 10.1111/tid.13722. Online ahead of print. PMID: 34496115
Pregnancy Outcomes After Living Liver Donation: A Multi-Institutional Study. Sonnenberg EM, Lee-Riddle GS, Walls DO, Caicedo JC, Jackson WE, Hughes L, Ladner DP, Liapakis A, Pomfret EA, Sarkar M, Selzner N, Torres AM, Abt PL, Olthoff KM. Liver Transpl. 2021 Sep;27(9):1262-1272. doi: 10.1002/lt.26098. Epub 2021 Jul 13. PMID: 33993632
Living Donor Liver Transplantation: Is Recipient Age a Barrier? Abu-Gazala S, Abt PL. Liver Transpl. 2021 Sep;27(9):1237-1238. doi: 10.1002/lt.26085. Epub 2021 Jul 31. PMID: 33905597
Occult Hepatocellular Carcinoma Associated With Transjugular Intrahepatic Portosystemic Shunts in Liver Transplant Recipients. Krumeich LN, Mancinelli J, Cucchiara A, Eddinger K, Aufhauser D Jr, Goldberg DW, Siegelman ES, Rosen M, Reddy KR, Hoteit M, Furth EE, Olthoff KM, Shaked A, Levine M, Abt P. Liver Transpl. 2021 Sep;27(9):1248-1261. doi: 10.1002/lt.26073. Epub 2021 Jul 21. PMID: 33853207 PMCID: PMC8429178
BLyS neutralization results in selective anti-HLA alloantibody depletion without successful desensitization. Agarwal D, Luning Prak ET, Bharani T, Everly M, Migone TS, Cancro M, Allman D, Choe I, Kearns JD, Trofe-Clark J, Naji A, Kamoun M. Transpl Immunol. 2021 Sep 7:101465. doi: 10.1016/j.trim.2021.101465. Online ahead of print. PMID: 34506905
Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation. Gaudette BT, Roman CJ, Ochoa TA, Gómez Atria D, Jones DD, Siebel CW, Maillard I, Allman D. J Clin Invest. 2021 Sep 2:151975. doi: 10.1172/JCI151975. Online ahead of print. PMID: 34473651
To build a plasma cell . Allman D. Immunol Rev. 2021 Sep;303(1):5-7. doi: 10.1111/imr.13017. Epub 2021 Aug 15. PMID: 34396544
The special unfolded protein response in plasma cells. Ricci D, Gidalevitz T, Argon Y. Immunol Rev. 2021 Sep;303(1):35-51. doi: 10.1111/imr.13012. Epub 2021 Aug 8. PMID: 34368957
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency. Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. PMID: 34358447
CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein-Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Response. Lee DSW, Yam JY, Grasmuck C, Dasoveanu D, Michel L, Ward LA, Rojas OL, Zandee S, Bourbonnière L, Ramaglia V, Bar-Or A, Prat A, Gommerman JL. J Immunol. 2021 Sep 15;207(6):1513-1521. doi: 10.4049/jimmunol.2001413. Epub 2021 Aug 16. PMID: 34400521
Long-term safety and efficacy of dimethyl fumarate for up to 13 years in patients with relapsing-remitting multiple sclerosis: Final ENDORSE study results. Gold R, Arnold DL, Bar-Or A, Fox RJ, Kappos L, Mokliatchouk O, Jiang X, Lyons J, Kapadia S, Miller C. Mult Scler. 2021 Sep 1:13524585211037909. doi: 10.1177/13524585211037909. Online ahead of print. PMID: 34465252
Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial . Reich DS, Arnold DL, Vermersch P, Bar-Or A, Fox RJ, Matta A, Turner T, Wallström E, Zhang X, Mareš M, Khabirov FA, Traboulsee A; Tolebrutinib Phase 2b Study Group. Lancet Neurol. 2021 Sep;20(9):729-738. doi: 10.1016/S1474-4422(21)00237-4. PMID: 34418400
Clinical Perspectives on the Molecular and Pharmacological Attributes of Anti-CD20 Therapies for Multiple Sclerosis. Bar-Or A, O'Brien SM, Sweeney ML, Fox EJ, Cohen JA. CNS Drugs. 2021 Sep;35(9):985-997. doi: 10.1007/s40263-021-00843-8. Epub 2021 Aug 9. PMID: 34370283
Siponimod: Disentangling disability and relapses in secondary progressive multiple sclerosis . Cree BA, Magnusson B, Rouyrre N, Fox RJ, Giovannoni G, Vermersch P, Bar-Or A, Gold R, Piani Meier D, Karlsson G, Tomic D, Wolf C, Dahlke F, Kappos L. Mult Scler. 2021 Sep;27(10):1564-1576. doi: 10.1177/1352458520971819. Epub 2020 Nov 18. PMID: 33205682
Pulmonary Outcomes After Autologous Stem Cell Transplant for Hodgkin Lymphoma. Davidow K, Bunin N, Goldfarb S, Li Y, Freedman JL. J Pediatr Hematol Oncol. 2021 Sep 6. doi: 10.1097/MPH.0000000000002301. Online ahead of print. PMID: 34486541
Endovascular cerebral aneurysm treatment volume during coronavirus 2019. Frank TS, Lee JE, Starke RM, Mokin M, Colby GP, Wang AC, Johnson J, Burkhardt JK, Srinivasan V, Raper DM, Albuquerque F, Kan P. Interv Neuroradiol. 2021 Sep 13:15910199211040278. doi: 10.1177/15910199211040278. Online ahead of print. PMID: 34515557
Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7. Guérin A, Roy NH, Kugler EM, Berry L, Burkhardt JK, Shin JB, Striepen B. Cell Host Microbe. 2021 Sep 8;29(9):1407-1420.e5. doi: 10.1016/j.chom.2021.07.002. Epub 2021 Aug 3. PMID: 34348092
Safety and efficacy of balloon-mounted stent in the treatment of symptomatic intracranial atherosclerotic disease: a multicenter experience. Mohammaden MH, Nogueira RG, Tekle W, Ortega-Gutierrez S, Farooqui M, Zevallos CB, Hanel RA, Cortez GM, Aghaebrahim A, Starke RM, Aref H, Elbassiouny A, Gamea A, Alaraj A, Sadeh M, Grigoryan M, Kuybu O, Haussen DC, Sheth SA, Maud A, Cordina SM, Tanweer O, Kan P, Burkhardt JK, Grandhi R, Siddiq F, Hassan AE. J Neurointerv Surg. 2021 Aug 4:neurintsurg-2021-017818. doi: 10.1136/neurintsurg-2021-017818. Online ahead of print. PMID: 34349013
Excess Serum Interleukin-18 Distinguishes Patients with Pathogenic Mutations in PSTPIP1. Stone DL, Ombrello A, Arostegui JI, Schneider C, Dang V, de Jesus A, Girard-Guyonvarc'h C, Gabay C, Lee W, Chae JJ, Aksentijevich I, Goldbach-Mansky RT, Kastner DL, Canna SW. Arthritis Rheumatol.2021 Sep 7. doi: 10.1002/art.41976. Online ahead of print. PMID: 34492165
Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia. Rapaport F, Neelamraju Y, Baslan T, Hassane D, Gruszczynska A, Robert de Massy M, Farnoud N, Haddox S, Lee T, Medina-Martinez J, Sheridan C, Thurmond A, Becker M, Bekiranov S, Carroll M, Moses Murdock H, Valk PJM, Bullinger L, D'Andrea R, Lowe SW, Neuberg D, Levine RL, Melnick A, Garrett-Bakelman FE. Leukemia. 2021 Sep;35(9):2688-2692. doi: 10.1038/s41375-021-01153-0. Epub 2021 Feb 12. PMID: 33580203
A genome-wide association meta-analysis identifies new Eosinophilic esophagitis loci. Chang X, March M, Mentch F, Nguyen K, Glessner J, Qu H, Liu Y, Furuta G, Aceves S, Gonsalves N, Nadeau K, Cianferoni A, Spergel J, Sleiman P, Hakonarson H. J Allergy Clin Immunol. 2021 Sep 7:S0091-6749(21)01358-0. doi: 10.1016/j.jaci.2021.08.018. Online ahead of print. PMID: 34506852
Oral Food Challenge for FPIES in Practice-A Survey: Report from the Work Group on FPIES Within the Adverse Reactions to Foods Committee, FAED IS, AAAAI. Nicolaides R, Bird JA, Cianferoni A, Brown-Whitehorn T, Nowak-Wegrzyn A. J Allergy Clin Immunol Pract. 2021 Sep 2:S2213-2198(21)00899-0. doi: 10.1016/j.jaip.2021.06.061. Online ahead of print. PMID: 34483087
The Role of the Environment in Eosinophilic Esophagitis. Cianferoni A, Jensen E, Davis CM. J Allergy Clin Immunol Pract. 2021 Sep;9(9):3268-3274. doi: 10.1016/j.jaip.2021.07.032. PMID: 34507708
Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Nat Immunol. 2021 Sep 29. doi: 10.1038/s41590-021-01057-2. Online ahead of print.
PMID: 34588688
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Lederer K, Parvathaneni K, Painter MM, Bettini E, Agarwal D, Lundgreen KA, Weirick M, Goel RR, Xu X, Drapeau EM, Gouma S, Greenplate AR, Coz CL, Romberg N, Jones L, Rosen M, Besharatian B, Kaminiski M, Weiskopf D, Sette A, Hensley SE, Bates P, Wherry EJ, Naji A, Bhoj V, Locci M. medRxiv. 2021 Sep 21:2021.09.16.21263686. doi: 10.1101/2021.09.16.21263686. Preprint.
PMID: 34580676
New-onset IgG autoantibodies in hospitalized patients with COVID-19. Chang SE, Feng A, Meng W, Apostolidis SA, Mack E, Artandi M, Barman L, Bennett K, Chakraborty S, Chang I, Cheung P, Chinthrajah S, Dhingra S, Do E, Finck A, Gaano A, Geßner R, Giannini HM, Gonzalez J, Greib S, Gündisch M, Hsu AR, Kuo A, Manohar M, Mao R, Neeli I, Neubauer A, Oniyide O, Powell AE, Puri R, Renz H, Schapiro J, Weidenbacher PA, Wittman R, Ahuja N, Chung HR, Jagannathan P, James JA, Kim PS, Meyer NJ, Nadeau KC, Radic M, Robinson WH, Singh U, Wang TT, Wherry EJ, Skevaki C, Luning Prak ET, Utz PJ. Nat Commun. 2021 Sep 14;12(1):5417. doi: 10.1038/s41467-021-25509-3. PMID: 34521836
Pembrolizumab for B-cell lymphomas relapsing after or refractory to CD19-directed CAR T-cell therapy. Chong EA, Alanio C, Svoboda J, Nasta SD, Landsburg DJ, Lacey SF, Ruella M, Bhattacharyya S, Wherry EJ, Schuster SJ. Blood. 2021 Sep 9:blood.2021012634. doi: 10.1182/blood.2021012634. Online ahead of print. PMID: 34496014
To build a plasma cell. Allman D. Immunol Rev. 2021 Sep;303(1):5-7. PMID: 34396544
Biochemical coordination of plasma cell genesis. Gaudette BT, Allman D. Immunol Rev. 2021 Sep;303(1):52-61. PMID: 34313339
Mitigating selection bias in organ allocation models. Schnellinger EM, Cantu E 3rd, Harhay MO, Schaubel DE, Kimmel SE, Stephens-Shields AJ. BMC Med Res Methodol. 2021 Sep 21;21(1):191. PMID: 34548017
Prospects for the Global Elimination of Hepatitis B. Block TM, Chang KM, Guo JT. Annu Rev Virol. 2021 Sep 29;8(1):437-458. PMID: 34586871
Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness. Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM. Crit Care Med. 2021 Sep 29. doi: 10.1097/CCM.0000000000005333. PMID: 34593707
COVID-19 Critical Illness: A Data-Driven Review. Ginestra JC, Mitchell OJL, Anesi GL, Christie JD. Annu Rev Med. 2021 Sep 14. doi: 10.1146/annurev-med-042420-110629. PMID: 34520220

August 2021

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Nat Immunol. 2021 Aug;22(8):1008-1019. doi: 10.1038/s41590-021-00975-5. Epub 2021 Jul 26. PMID: 34312545
Identification of Novel Neutralizing Monoclonal Antibodies against SARS-CoV-2 Spike Glycoprotein. Bordoloi D, Xu Z, Ho M, Purwar M, Bhojnagarwala P, Cassel J, Giron LB, Walker S, Kulkarni AJ, Ruiz ET, Choi J, Zaidi FI, Wu Y, Wang S, Patel A, Ramos S, Smith T, Kulp D, Ugen KE, Srinivasan A, Abdel-Mohsen M, Humeau L, Weiner DB, Muthumani K. ACS Pharmacol Transl Sci. 2021 Jul 29;4(4):1349-1361. PMID: 34396059 PMCID: PMC8353887
Center Variability in Acute Rejection and Biliary Complications after Pediatric Liver Transplantation. Kanneganti M, Xu Y, Huang YS, Kitt E, Fisher BT, Abt PL, Rand EB, Schaubel DE, Bittermann T. Liver Transpl. 2021 Aug 8. doi: 10.1002/lt.26259 PMID: 34365719
CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein-Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Response. Lee DSW, Yam JY, Grasmuck C, Dasoveanu D, Michel L, Ward LA, Rojas OL, Zandee S, Bourbonnière L, Ramaglia V, Bar-Or A, Prat A, Gommerman JL. J Immunol. 2021 Aug 16:ji2001413. PMID: 34400521
Clinical Perspectives on the Molecular and Pharmacological Attributes of Anti-CD20 Therapies for Multiple Sclerosis. Bar-Or A, O'Brien SM, Sweeney ML, Fox EJ, Cohen JA. CNS Drugs. 2021 Aug 9:1-13. PMID: 34370283
Vaccination and multiple sclerosis in the era of the COVID-19 pandemic. Monschein T, Hartung HP, Zrzavy T, Barnett M, Boxberger N, Berger T, Chataway J, Bar-Or A, Rommer PS, Zettl UK. J Neurol Neurosurg Psychiatry. 2021 Aug 5:jnnp-2021-326839. PMID: 34353858
Distinct Bioenergetic Features of Human Invariant Natural Killer T Cells Enable Retained Functions in Nutrient-Deprived States. Khurana P, Burudpakdee C, Grupp SA, Beier UH, Barrett DM, Bassiri H. Front Immunol. 2021 Aug 9;12:700374. PMID: 34434191 PMCID: PMC8380770
Skewed Cytokine Responses Rather Than the Magnitude of the Cytokine Storm May Drive Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children. Chang JC, Matsubara D, Morgan RW, Diorio C, Nadaraj S, Teachey DT, Bassiri H, Behrens EM, Banerjee A. J Am Heart Assoc. 2021 Aug 17;10(16):e021428. PMID: 34365798
The biological underpinnings of therapeutic resistance in pancreatic cancer. Beatty GL, Werba G, Lyssiotis CA, Simeone DM. Genes Dev. 2021 Jul 1;35(13-14):940-962. PMID: 34117095 PMCID: PMC8247606
Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury. Akimova T, Zhang T, Christensen LM, Wang Z, Han R, Negorev D, Samanta A, Sasson IE, Gaddapara T, Jiao J, Wang L, Bhatti TR, Levine MH, Diamond JM, Beier UH, Simmons RA, Cantu E, Wilkes DS, Lederer DJ, Anderson M, Christie JD, Hancock WW. Am J Respir Crit Care Med. 2021 Aug 4. PMID: 34346860
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates. Zabaleta N, Dai W, Bhatt U, Hérate C, Maisonnasse P, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Naninck T, Kahlaoui N, Lemaitre J, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Contreras V, Marlin R, Tsong Fang RH, Chapon C, van der Werf S, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Le Grand R, Vandenberghe LH. Cell Host Microbe. 2021 Aug 7:S1931-3128(21)00378-4. PMID: 34428428 PMCID: PMC8346325
Urine Lipoarabinomannan Testing in Adults With Advanced Human Immunodeficiency Virus in a Trial of Empiric Tuberculosis Therapy. Matoga MM, Bisson GP, Gupta A, Miyahara S, Sun X, Fry C, Manabe YC, Kumwenda J, Cecilia K, Nyirenda M, Ngongondo M, Mbewe A, Lagat D, Wallis C, Mugerwa H, Hosseinipour MC. Clin Infect Dis. 2021 Aug 16;73(4):e870-e877. PMID: 34398958 PMCID: PMC8366821
Memory B cells and plasma cells: The differentiative continuum of humoral immunity. Cancro MP, Tomayko MM. Immunol Rev. 2021 Sep;303(1):72-82. PMID: 34396546
Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ. Van Der Kraak LA, Schneider C, Dang V, Burr AHP, Weiss ES, Varghese JA, Yang L, Hand TW, Canna SW. Mucosal Immunol. 2021 Sep;14(5):1100-1112. PMID: 34103660
Lung Transplantation Outcomes after Crossing Low-Level Donor Specific Antibodies Without Planned Augmented Immunosuppression. Courtwright AM, Kamoun M, Diamond JM, Kearns J, Ahya VN, Christie JD, Clausen E, Hadjiliadis D, Patel N, Salgado JC, Cevasco M, Cantu EE, Crespo MM, Bermudez CA. Clin Transplant. 2021 Aug 8. PMID: 34365656
Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model. Kim MM, Verginadis II, Goia D, Haertter A, Shoniyozov K, Zou W, Maity A, Busch TM, Metz JM, Cengel KA, Dong L, Koumenis C, Diffenderfer ES. Cancers (Basel). 2021 Aug 23;13(16):4244. PMID: 34439398
American Association for the Study of Liver Diseases Expert Panel Consensus Statement: Vaccines to Prevent Coronavirus Disease 2019 Infection in Patients With Liver Disease. Fix OK, Blumberg EA, Chang KM, Chu J, Chung RT, Goacher EK, Hameed B, Kaul DR, Kulik LM, Kwok RM, McGuire BM, Mulligan DC, Price JC, Reau NS, Reddy KR, Reynolds A, Rosen HR, Russo MW, Schilsky ML, Verna EC, Ward JW, Fontana RJ; AASLD COVID-19 Vaccine Working Group. Hepatology. 2021 Aug;74(2):1049-1064. PMID: 33577086 PMCID: PMC8014184
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking. Chen H, Li Z, Feng S, Richard-Greenblatt M, Hutson E, Andrianus S, Glaser LJ, Rodino KG, Qian J, Jayaraman D, Collman RG, Glascock A, Bushman FD, Lee JS, Cherry S, Fausto A, Weiss SR, Koo H, Corby PM, Oceguera A, O'Doherty U, Garfall AL, Vogl DT, Stadtmauer EA, Wang P. Clin Chem. 2021 Aug 12:hvab158. PMID: 34383886
Multiplexed detection of SARS-CoV-2 genomic and subgenomic RNA using in situ hybridization. Acheampong KK, Schaff DL, Emert BL, Lake J, Reffsin S, Shea EK, Comar CE, Litzky LA, Khurram NA, Linn RL, Feldman M, Weiss SR, Montone KT, Cherry S, Shaffer SM. bioRxiv. 2021 Aug 11:2021.08.11.455959. PMID: 34401878
Redondovirus diversity and evolution on global, individual, and molecular scales. Taylor LJ, Dothard MI, Rubel MA, Allen AA, Hwang Y, Roche AM, Graham-Wooten J, Fitzgerald AS, Khatib LA, Ranciaro A, Thompson SR, Beggs WR, Campbell MC, Mokone GG, Mpoloka SW, Fokunang C, Njamnshi AK, Mbunwe E, Woldemeskel D, Belay G, Nyambo T, Tishkoff SA, Collman RG, Bushman FD. J Virol. 2021 Aug 18:JVI0081721. PMID: 34406857
Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome. Merenstein C, Liang G, Whiteside SA, Cobián-Güemes AG, Merlino MS, Taylor LJ, Glascock A, Bittinger K, Tanes C, Graham-Wooten J, Khatib LA, Fitzgerald AS, Reddy S, Baxter AE, Giles JR, Oldridge DA, Meyer NJ, Wherry EJ, McGinniss JE, Bushman FD, Collman RG. mBio. 2021 Aug 17:e0177721. PMID: 34399607
The lung microbiome: progress and promise. Whiteside SA, McGinniss JE, Collman RG. J Clin Invest. 2021 Aug 2;131(15):e150473. PMID: 34338230 PMCID: PMC8321564
The lung microbiome in lung transplantation. McGinniss JE, Whiteside SA, Simon-Soro A, Diamond JM, Christie JD, Bushman FD, Collman RG. J Heart Lung Transplant. 2021 Aug;40(8):733-744. PMID: 34120840 PMCID: PMC8335643
Phase II Study of Maintenance Rucaparib in Patients With Platinum-Sensitive Advanced Pancreatic Cancer and a Pathogenic Germline or Somatic Variant in BRCA1, BRCA2, or PALB2. Reiss KA, Mick R, O'Hara MH, Teitelbaum U, Karasic TB, Schneider C, Cowden S, Southwell T, Romeo J, Izgur N, Hannan ZM, Tondon R, Nathanson K, Vonderheide RH, Wattenberg MM, Beatty G, Domchek SM. J Clin Oncol. 2021 Aug 1;39(22):2497-2505. doi: 10.1200/JCO.21.00003. Epub 2021 May 10. PMID: 33970687
Interpretative differences of combined cytogenetic and molecular profiling highlights differences between MRC and ELN classifications of AML. Sussman RT, Manning B, Ackerman D, Bigdeli A, Pammer P, Velu PD, Luger SM, Bagg A, Carroll M, Morrissette JJD. Cancer Genet. 2021 Aug;256-257:68-76. doi: 10.1016/j.cancergen.2021.04.004. Epub 2021 Apr 16. PMID: 33915454
Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model. Kim MM, Verginadis II, Goia D, Haertter A, Shoniyozov K, Zou W, Maity A, Busch TM, Metz JM, Cengel KA, Dong L, Koumenis C, Diffenderfer ES. Cancers (Basel). 2021 Aug 23;13(16):4244. doi: 10.3390/cancers13164244. PMID: 34439398
Hepatitis B e antigen loss in adults and children with chronic hepatitis B living in North America: A prospective cohort study. Lee WM, King WC, Janssen HLA, Ghany MG, Fontana RJ, Fried M, Sterling RK, Feld JJ, Wang J, Mogul DB, Cooper SL, Bisceglie AMD; Hepatitis B Research Network (HBRN) .J Viral Hepat. 2021 Aug 6. doi: 10.1111/jvh.13591. Online ahead of print. PMID: 34355475
Set Up for Failure: Pre-Existing Autoantibodies in Lung Transplant. McQuiston A, Emtiazjoo A, Angel P, Machuca T, Christie J, Atkinson C. Front Immunol. 2021 Aug 11;12:711102. doi: 10.3389/fimmu.2021.711102. eCollection 2021. PMID: 34456920
Oral delivery of therapeutic proteins bioencapsulated in plant cells: preclinical and clinical advances . Khan I, Daniell H. Curr Opin Colloid Interface Sci. 2021 Aug;54:101452. doi: 10.1016/j.cocis.2021.101452. Epub 2021 Mar 24. PMID: 33967586
A Randomized Phase 2 Study Of Nivolumab Monotherapy Or Nivolumab Combined with Ipilimumab In Patients with Advanced Gastrointestinal Stromal Tumors. Singh AS, Hecht JR, Rosen L, Wainberg ZA, Wang X, Douek M, Hagopian A, Andes R, Sauer L, Brackert SR, Chow W, DeMatteo R, Eilber FC, Glaspy JA, Chmielowski B. Clin Cancer Res. 2021 Aug 18:clincanres.0878.2021. doi: 10.1158/1078-0432.CCR-21-0878. Online ahead of print. PMID: 34407970
What is the patient experience of surgical care during the coronavirus disease 2019 (COVID-19) pandemic? A mixed-methods study at a single institution . Shannon AB, Roberson JL, Clapp JT, Vaughan C, Kleid M, Song Y, Miura JT, Dempsey DT, DeMatteo RP, Fleisher LA, Karakousis GC. Surgery. 2021 Aug;170(2):550-557. doi: 10.1016/j.surg.2020.12.031. Epub 2020 Dec 29. PMID: 33715849
Sex Differences in Cardiovascular Outcomes in CKD: Findings From the CRIC Study. Toth-Manikowski SM, Yang W, Appel L, Chen J, Deo R, Frydrych A, Krousel-Wood M, Rahman M, Rosas SE, Sha D, Wright J, Daviglus ML, Go AS, Lash JP, Ricardo AC; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Am J Kidney Dis. 2021 Aug;78(2):200-209.e1. doi: 10.1053/j.ajkd.2021.01.020. Epub 2021 Apr 20. PMID: 33857532

July 2021

Trends in Liver Transplantation for Acute Alcohol-Associated Hepatitis During the COVID-19 Pandemic in the US. Bittermann T, Mahmud N, Abt P. JAMA Netw Open. 2021 Jul 1;4(7):e2118713. doi: 10.1001/jamanetworkopen.2021.18713. PMID: 34323988
Biochemical coordination of plasma cell genesis. Gaudette BT, Allman D. Immunol Rev. 2021 Jul 26. doi: 10.1111/imr.12992. Online ahead of print. PMID: 34313339 Review.
An Open-Source Toolkit To Expand Bioinformatics Training in Infectious Diseases. Berry ASF, Farias Amorim C, Berry CL, Syrett CM, English ED, Beiting DP. mBio. 2021 Jul 6:e0121421. doi: 10.1128/mBio.01214-21. Online ahead of print. PMID: 34225494
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells. Di Giorgio E, Wang L, Xiong Y, Christensen LM, Akimova T, Han R, Samanta A, Trevisanut M, Brancolini C, Beier UH, Hancock WW. Front Immunol.2021 Jul 5;12:703632. doi: 10.3389/fimmu.2021.703632. eCollection 2021. PMID: 34290714 PMCID: PMC8287581
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling. Chen KW, Demarco B, Ramos S, Heilig R, Goris M, Grayczyk JP, Assenmacher CA, Radaelli E, Joannas LD, Henao-Mejia J, Tacchini-Cottier F, Brodsky IE, Broz P. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2101189118. doi: 10.1073/pnas.2101189118. PMID: 34260403 PMCID: PMC8285957
Immune Dysregulation in Human ITCH Deficiency Successfully Treated with Hematopoietic Cell Transplantation. Patel T, Henrickson SE, Moser EK, Field NS, Maurer K, Dawany N, Conrad M, Bunin N, Freedman JL, Heimall J, Arnold DE, Wang J, Markowitz JE, Payne-Poff SB, Williams KW, Russo PA, Wherry EJ, Devoto M, Oliver P, Sullivan KE, Kelsen JR. J Allergy Clin Immunol Pract. 2021 Jul;9(7):2885-2893.e3. doi: 10.1016/j.jaip.2021.04.010. Epub 2021 Apr 21. PMID: 33894394
Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting. Bear AS, Blanchard T, Cesare J, Ford MJ, Richman LP, Xu C, Baroja ML, McCuaig S, Costeas C, Gabunia K, Scholler J, Posey AD Jr, O'Hara MH, Smole A, Powell DJ Jr, Garcia BA, Vonderheide RH, Linette GP, Carreno BM. Nat Commun. 2021 Jul 16;12(1):4365. doi: 10.1038/s41467-021-24562-2. PMID: 34272369 PMCID: PMC8285372
FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Velalopoulou A, Karagounis IV, Cramer GM, Kim MM, Skoufos G, Goia D, Hagan S, Verginadis II, Shoniyozov K, Chiango J, Cerullo M, Varner K, Yao L, Qin L, Hatzigeorgiou AG, Minn AJ, Putt M, Lanza M, Assenmacher CA, Radaelli E, Huck J, Diffenderfer E, Dong L, Metz J, Koumenis C, Cengel KA, Maity A, Busch TM. Cancer Res. 2021 Jul 28:canres.1500.2021. doi: 10.1158/0008-5472.CAN-21-1500. Online ahead of print. PMID: 34321243
Adjuvant Photodynamic Therapy, Mediated via Topical Versus Systemic Administration of 5-Aminolevulinic Acid for Control of Murine Mammary Tumor after Surgical Resection†. Carter S, Miller J, Cramer G, Yuan M, Guzman S, Putt ME, Cengel KA, Freedman GM, Busch TM. Photochem Photobiol. 2021 Jul 5. doi: 10.1111/php.13482. Online ahead of print. PMID: 34224156
Characterization of a high-resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery. Zou W, Diffenderfer ES, Ota K, Boisseau P, Kim MM, Cai Y, Avery SM, Carlson DJ, Wiersma RD, Lin A, Koumenis C, Cengel KA, Metz JM, Dong L, Teo BK. Med Phys. 2021 Jul;48(7):3948-3957. doi: 10.1002/mp.14882. Epub 2021 Jun 3. PMID: 33843065
RNA sequencing identifies global transcriptional changes in peripheral CD4+ cells during active oesophagitis and following epicutaneous immunotherapy in eosinophilic oesophagitis. Ruffner MA, Zhang Z, Maurer K, Muir AB, Cianferoni A, Sullivan KE, Spergel JM. Clin Transl Immunology. 2021 Jul 22;10(7):e1314. doi: 10.1002/cti2.1314. eCollection 2021. PMID: 34322233
Erythrocytes Identify Complement Activation in Patients with COVID-19. Lam LM, Reilly JP, Rux AH, Murphy S, Kuri-Cervantes L, Weisman A, Ittner CA, Pampena MB, Betts M, Wherry EJ, Song WC, Lambris JD, Meyer NJ, Cines DB, Mangalmurti NS. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 7. doi: 10.1152/ajplung.00231.2021. Online ahead of print. PMID: 34231390
COVID-19 vaccination and immune thrombocytopenia. Pishko AM, Bussel JB, Cines DB. Nat Med. 2021 Jul;27(7):1145-1146. doi: 10.1038/s41591-021-01419-1. PMID: 34108715
Alpha-defensins: risk factor for thrombosis in COVID-19 infection. Abdeen S, Bdeir K, Abu-Fanne R, Maraga E, Higazi M, Khurram N, Feldman M, Deshpande C, Litzky LA, Heyman SN, Montone KT, Cines DB, Higazi AA. Br J Haematol. 2021 Jul;194(1):44-52. doi: 10.1111/bjh.17503. Epub 2021 May 30. PMID: 34053084
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Du M, Garcia JGN, Christie JD, Xin J, Cai G, Meyer NJ, Zhu Z, Yuan Q, Zhang Z, Su L, Shen S, Dong X, Li H, Hutchinson JN, Tejera P, Lin X, Wang M, Chen F, Christiani DC. Intensive Care Med.2021 Jul;47(7):761-771. doi: 10.1007/s00134-021-06410-5. Epub 2021 May 25. PMID: 34032881
Comparative safety of dipeptidyl peptidase-4 inhibitors and sudden cardiac arrest and ventricular arrhythmia: Population-based cohort studies. Dawwas GK, Hennessy S, Brensinger CM, Deo R, Bilker WB, Soprano SE, Dhopeshwarkar N, Flory JH, Bloomgarden ZT, Aquilante CL, Kimmel SE, Leonard CE. Clin Pharmacol Ther. 2021 Jul 31. doi: 10.1002/cpt.2381. Online ahead of print. PMID: 34331322
Number of opioid overdoses and depression as a predictor of suicidal thoughts. Brown LA, Denis CM, Leon A, Blank MB, Douglas SD, Morales KH, Crits-Christoph PF, Metzger DS, Evans DL. Drug Alcohol Depend. 2021 Jul 1;224:108728. doi: 10.1016/j.drugalcdep.2021.108728. Epub 2021 Apr 24. PMID: 33971515
HIV Infection and Depression Among Opiate Users in a US Epicenter of the Opioid Epidemic. Denis CM, Dominique T, Smith P, Fiore D, Ku YC, Culhane A, Dunbar D, Brown D, Daramay M, Voytek C, Morales KH, Blank MB, Crits-Christoph PF, Douglas SD, Spitsin S, Frank I, Colon-Rivera K, Montaner LJ, Metzger DS, Evans DL. AIDS Behav. 2021 Jul;25(7):2230-2239. doi: 10.1007/s10461-020-03151-2. Epub 2021 Jan 15. PMID: 33449236
DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells. Lim JY, Duttke SH, Baker TS, Lee J, Gambino KJ, Venturini NJ, Ho JSY, Zheng S, Fstkchyan YS, Pillai V, Fajgenbaum DC, Marazzi I, Benner C, Byun M. J Exp Med. 2021 Jul 5;218(7):e20202733. doi: 10.1084/jem.20202733. Epub 2021 May 10. PMID: 33970190
Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease. Nishimura Y, Fajgenbaum DC, Pierson SK, Iwaki N, Nishikori A, Kawano M, Nakamura N, Izutsu K, Takeuchi K, Nishimura MF, Maeda Y, Otsuka F, Yoshizaki K, Oksenhendler E, van Rhee F, Sato Y. Am J Hematol. 2021 Jul 15. doi: 10.1002/ajh.26292. Online ahead of print. PMID: 34265103
Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate. Mehta P, Fajgenbaum DC. Curr Opin Rheumatol. 2021 Jul 15. doi: 10.1097/BOR.0000000000000822. Online ahead of print. PMID: 34264880
Commentary: "Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and Its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing. Lucas A, Eberwine JH, Bagley SJ, Fan Y, Nasrallah MP, Brem S. Neurosurgery. 2021 Jul 31:nyab288. doi: 10.1093/neuros/nyab288. Online ahead of print. PMID: 34332498
18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Following Chimeric Antigen Receptor T-cell Therapy in Large B-cell Lymphoma. Ruff A, Ballard HJ, Pantel AR, Namoglu EC, Hughes ME, Nasta SD, Chong EA, Bagg A, Ruella M, Farwell MD, Svoboda J, Sellmyer MA. Mol Imaging Biol. 2021 Jul 6. doi: 10.1007/s11307-021-01627-8. Online ahead of print. PMID: 34231105
Clinical features and outcome of acquired myasthenia gravis in 94 dogs. Forgash JT, Chang YM, Mittelman NS, Petesch S, Benedicenti L, Galban E, Hammond JJ, Glass EN, Barker JR, Shelton GD, Luo J, Garden OA. J Vet Intern Med. 2021 Jul 31. doi: 10.1111/jvim.16223. Online ahead of print. PMID: 34331481
Subclinical Liver Disease is Associated with Subclinical Atherosclerosis in Psoriasis: Results from Two Observational Studies. Gonzalez-Cantero A, Teklu M, Sorokin AV, Prussick R, González-Cantero J, Martin-Rodriguez JL, Patel N, Parel PM, Manyak GA, Teague HL, Rodante JA, Keel A, Pérez-Hortet C, Sanchéz-Moya AI, Jiménez N, Ballester A, Solis J, Fernandez-Friera L, Barderas MG, Gonzalez-Calvin JL, Jaen P, Playford MP, Dey AK, Gelfand JM, Mehta NN. J Invest Dermatol. 2021 Jul 19:S0022-202X(21)01461-5. doi: 10.1016/j.jid.2021.05.034. Online ahead of print. PMID: 34293354
Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors. Guidon AC, Burton LB, Chwalisz BK, Hillis J, Schaller TH, Amato AA, Betof Warner A, Brastianos PK, Cho TA, Clardy SL, Cohen JV, Dietrich J, Dougan M, Doughty CT, Dubey D, Gelfand JM, Guptill JT, Johnson DB, Juel VC, Kadish R, Kolb N, LeBoeuf NR, Linnoila J, Mammen AL, Martinez-Lage M, Mooradian MJ, Naidoo J, Neilan TG, Reardon DA, Rubin KM, Santomasso BD, Sullivan RJ, Wang N, Woodman K, Zubiri L, Louv WC, Reynolds KL J Immunother Cancer. 2021 Jul;9(7):e002890. doi: 10.1136/jitc-2021-002890. PMID: 34281989 PMCID: PMC8291304
Disabling the Nuclear Translocalization of RelA/NF-κB by a Small Molecule Inhibits Triple-Negative Breast Cancer Growth. Kanzaki H, Chatterjee A, Hossein Nejad Ariani H, Zhang X, Chung S, Deng N, Ramanujan VK, Cui X, Greene MI, Murali R. Breast Cancer (Dove Med Press). 2021 Jul 5;13:419-430. doi: 10.2147/BCTT.S310231. eCollection 2021. PMID: 34262338 PMCID: PMC8275049
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion. Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobsen EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T. Science. 2021 Jul 30;373(6554):eabd2893. doi: 10.1126/science.abd2893. PMID: 34326208
Integrin Crosstalk Modulates Stiffness-independent Motility of CD4+ T Lymphocytes. Kim SHJ, Hammer DA. Mol Biol Cell. 2021 Jul 7:mbcE21030131. doi: 10.1091/mbc.E21-03-0131. Online ahead of print. PMID: 34232700
Health care worker sero-monitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration. Gouma S, Weirick ME, Bolton MJ, Arevalo CP, Goodwin EC, Anderson EM, McAllister CM, Christensen SR, Dunbar D, Fiore D, Brock A, Weaver J, Millar JS, DerOhannessian S, Frank I, Rader DJ, Wherry EJ, Hensley SE. JCI Insight. 2021 Jul 8:150449. doi: 10.1172/jci.insight.150449. Online ahead of print. PMID: 34237028
Immune Dysregulation in Human ITCH Deficiency Successfully Treated with Hematopoietic Cell Transplantation. Patel T, Henrickson SE, Moser EK, Field NS, Maurer K, Dawany N, Conrad M, Bunin N, Freedman JL, Heimall J, Arnold DE, Wang J, Markowitz JE, Payne-Poff SB, Williams KW, Russo PA, Wherry EJ, Devoto M, Oliver P, Sullivan KE, Kelsen JR. J Allergy Clin Immunol Pract. 2021 Jul;9(7):2885-2893.e3. doi: 10.1016/j.jaip.2021.04.010. Epub 2021 Apr 21. PMID: 33894394
Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma. Karmacharya MB, Sultan LR, Hunt SJ, Sehgal CM. Sci Rep. 2021 Jul 30;11(1):15553. doi: 10.1038/s41598-021-94323-0. PMID: 34330960 PMCID: PMC8324788
Demographic Trends in Female Interventional Radiology Trainees With the Advent of the Integrated Interventional Radiology Residency. Parikh RS, Shamimi-Noori S, Reddy S, Gade T, Nadolski GJ, Hunt SJ. J Am Coll Radiol. 2021 Jul 8:S1546-1440(21)00546-9. doi: 10.1016/j.jacr.2021.06.016. Online ahead of print. PMID: 34246646
Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells. Thakur A, Scholler J, Kubicka E, Bliemeister ET, Schalk DL, June CH, Lum LG. Front Immunol. 2021 Jul 5;12:690437. doi: 10.3389/fimmu.2021.690437. eCollection 2021. PMID: 34290709 PMCID: PMC8288104
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling. Sharma P, Yadav SK, Shah SD, Javed E, Lim JM, Pan S, Nayak AP, Panettieri RA Jr, Penn RB, Kambayashi T, Deshpande DA. Am J Respir Cell Mol Biol. 2021 Jul 22. doi: 10.1165/rcmb.2021-0106OC. Online ahead of print. PMID: 34293268
Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase. Yadav SK, Sharma P, Shah SD, Panettieri RA, Kambayashi T, Penn RB, Deshpande DA. J Cell Physiol. 2021 Jul 18. doi: 10.1002/jcp.30528. Online ahead of print. PMID: 34278583
Identifying Patients at Highest Risk of Remaining Unvaccinated against SARS-CoV-2 in a Large Veterans Health Administration Cohort. Mahmud N, Chapin SE, Kaplan DE, Marina S. Liver Transpl. 2021 Jul 22. doi: 10.1002/lt.26235. Online ahead of print. PMID: 34293247
Risk Prediction Models for Postoperative Decompensation and Infection in Patients With Cirrhosis: A Veterans Affairs Cohort Study. Mahmud N, Fricker Z, Lewis JD, Taddei TH, Goldberg DS, Kaplan DE. Clin Gastroenterol Hepatol. 2021 Jul 8:S1542-3565(21)00721-7. doi: 10.1016/j.cgh.2021.06.050. Online ahead of print. PMID: 34246794
Impact of SGLT2 inhibitors in comparison with DPP4 inhibitors on ascites and death in veterans with cirrhosis on metformin. Saffo S, Kaplan DE, Mahmud N, Serper M, John BV, Ross JS, Taddei T. Diabetes Obes Metab. 2021 Jul 6. doi: 10.1111/dom.14488. Online ahead of print. PMID: 34227216
Genetics of HLA Peptide Presentation and Impact on Outcomes in HLA-Matched Allogeneic Hematopoietic Cell Transplantation. Story CM, Wang T, Bhatt VR, Battiwalla M, Badawy SM, Kamoun M, Gragert L, Brown V, Baxter-Lowe LA, Marsh SGE, Gadalla SM, Schetelig J, Mytilineos J, Miklos D, Waller EK, Kuxhausen M, Spellman S, Lee S, Paczesny S, Lansford JL, Vincent BG, Riches ML, Armistead PM; Center for International Blood and Marrow Transplant Research Immunobiology Working Committee. Transplant Cell Ther. 2021 Jul;27(7):591-599. doi: 10.1016/j.jtct.2021.04.003. Epub 2021 Apr 18. PMID: 33882342 PMCID: PMC8343993
An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement. O'Donnell JC, Purvis EM, Helm KVT, Adewole DO, Zhang Q, Le AD, Cullen DK. Commun Biol. 2021 Jul 15;4(1):879. doi: 10.1038/s42003-021-02392-8. PMID: 34267315 PMCID: PMC8282659
TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells. Garcia de Mattos Barbosa M, Lefferts AR, Huynh D, Liu H, Zhang Y, Fu B, Barnes J, Samaniego M, Bram RJ, Geha R, Shikanov A, Luning Prak ET, Farkash EA, Platt JL, Cascalho M. JCI Insight. 2021 Jul 20:150483. doi: 10.1172/jci.insight.150483. Online ahead of print. PMID: 34283811
Advancing precision medicine for acute respiratory distress syndrome. Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Lancet Respir Med. 2021 Jul 23:S2213-2600(21)00157-0. doi: 10.1016/S2213-2600(21)00157-0. Online ahead of print. PMID: 34310901 PMCID: PMC8302189
The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU. Prasad N, Grossestreuer AV, Meyer NJ, Perman SM, Mikkelsen ME, Hollander J, Gaieski DF. Sci Rep. 2021 Jul 23;11(1):15114. doi: 10.1038/s41598-021-94473-1. PMID: 34302025
Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate with Organ Dysfunction and Mortality in Sepsis. Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Weisman AR, Agyekum R, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ. Shock. 2021 Jul 8. doi: 10.1097/SHK.0000000000001833. Online ahead of print. PMID: 34265829
Acute respiratory distress syndrome. Meyer NJ, Gattinoni L, Calfee CS. Lancet. 2021 Jul 1:S0140-6736(21)00439-6. doi: 10.1016/S0140-6736(21)00439-6. Online ahead of print. PMID: 34217425
Developing a composite outcome tool to measure response to treatment in ANCA-associated vasculitis: A mixed methods study from OMERACT 2020. Quinn KA, Monti S, Christensen R, Jayne D, Langford CA, Lanier GE, Mahr A, Pagnoux C, Shea B, Tugwell P, Viðarsdóttir MB, Tomasson G, Merkel PA. Semin Arthritis Rheum. 2021 Jul 8:S0049-0172(21)00125-6. doi: 10.1016/j.semarthrit.2021.07.001. Online ahead of print. PMID: 34274125
BCL6 BTB-specific inhibitor reversely represses T Cell activation, Tfh cells differentiation and germinal center reaction in vivo. Cai Y, Poli ANR, Vadrevu S, Gyampoh K, Hart C, Ross B, Fair M, Xue F, Salvino JM, Montaner LJ. Eur J Immunol. 2021 Jul 21. doi: 10.1002/eji.202049150. Online ahead of print. PMID: 34287839
Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies. Poussin M, Sereno A, Wu X, Huang F, Manro J, Cao S, Carpenito C, Glasebrook A, Powell DJ Jr, Demarest S. J Immunother Cancer. 2021 Jul;9(7):e002444. doi: 10.1136/jitc-2021-002444. PMID: 34253637 PMCID: PMC8276301
Letter to the Editor in response to "Response to Kovanen PT, et al. Letter to the Editor" for original article COVID-19 increases risk of myocardial infarction in persons with familial hypercholesterolemia with or without ASCVD. Myers KD, Wilemon K, McGowan MP, Howard W, Staszak D, Rader DJ. Am J Prev Cardiol. 2021 Sep;7:100225. doi: 10.1016/j.ajpc.2021.100225. Epub 2021 Jul 20. PMID: 34308404
Associations of HDL metrics with coronary artery calcium score and density among women traversing menopause. El Khoudary SR, Nasr A, Matthews KA, Orchard TJ, Brooks MM, Billheimer J, McConnell D, Janssen I, Everson-Rose SA, Crawford S, Rader DJ. J Lipid Res. 2021 Jul 22:100098. doi: 10.1016/j.jlr.2021.100098. Online ahead of print. PMID: 34303684
A Genome-First Approach to Rare Variants in Dominant Postlingual Hearing Loss Genes in a Large Adult Population. Ahmadmehrabi S, Li B, Hui D, Park J, Ritchie M, Rader DJ, Ruckenstein MJ, Epstein DJ, Brant J. Otolaryngol Head Neck Surg. 2021 Jul 20:1945998211029544. doi: 10.1177/01945998211029544. Online ahead of print. PMID: 34281439
A genome-first approach to mortality and metabolic phenotypes in MTARC1 p.Ala165Thr (rs2642438) heterozygotes and homozygotes. Schneider CV, Schneider KM, Conlon DM, Park J, Vujkovic M, Zandvakili I, Ko YA, Trautwein C, Center R, Carr RM, Strnad P, Thaiss CA, Rader DJ. Med (N Y). 2021 Jul 9;2(7):851-863.e3. doi: 10.1016/j.medj.2021.04.011. PMID: 34258604
Understanding VITT(ual) reality. Rauova L, Poncz M. Blood. 2021 Jul 29;138(4):285-286. doi: 10.1182/blood.2021012524. PMID: 34323943 PMCID: PMC8320444
COVID-19 vaccination: possible short-term exacerbations of oral mucosal diseases. Kulkarni R, Sollecito TP. Int J Dermatol. 2021 Jul 12. doi: 10.1111/ijd.15779. Online ahead of print. PMID: 34251026
Management of Eosinophilic Esophagitis During Oral Immunotherapy. Chu DK, Spergel JM, Vickery BP. J Allergy Clin Immunol Pract. 2021 Jul 26:S2213-2198(21)00818-7. doi: 10.1016/j.jaip.2021.07.017. Online ahead of print. PMID: 34325036
Development of the Child- and Parent-Rated Scales of Food Allergy Anxiety (SOFAA). Dahlsgaard KK, Wilkey LK, Stites SD, Lewis MO, Spergel JM. J Allergy Clin Immunol Pract. 2021 Jul 12:S2213-2198(21)00770-4. doi: 10.1016/j.jaip.2021.06.039. Online ahead of print. PMID: 34265450
Ruxolitinib: Targeted Approach for Treatment of Autoinflammatory Very Early Onset- Inflammatory Bowel Disease. Rudra S, Shaul E, Conrad M, Patel T, Moore A, Dawany N, Canavan MC, Sullivan KE, Behrens E, Kelsen JR. Clin Gastroenterol Hepatol. 2021 Jul 27:S1542-3565(21)00822-3. doi: 10.1016/j.cgh.2021.07.040. Online ahead of print. PMID: 34329777
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients. Le Coz C, Nguyen DN, Su C, Nolan BE, Albrecht AV, Xhani S, Sun D, Demaree B, Pillarisetti P, Khanna C, Wright F, Chen PA, Yoon S, Stiegler AL, Maurer K, Garifallou JP, Rymaszewski A, Kroft SH, Olson TS, Seif AE, Wertheim G, Grant SFA, Vo LT, Puck JM, Sullivan KE, Routes JM, Zakharova V, Shcherbina A, Mukhina A, Rudy NL, Hurst ACE, Atkinson TP, Boggon TJ, Hakonarson H, Abate AR, Hajjar J, Nicholas SK, Lupski JR, Verbsky J, Chinn IK, Gonzalez MV, Wells AD, Marson A, Poon GMK, Romberg N. J Exp Med. 2021 Jul 5;218(7):e20201750. doi: 10.1084/jem.20201750. Epub 2021 May 5. PMID: 33951726 PMCID: PMC8105723
Identification of 22 susceptibility loci associated with testicular germ cell tumors. Pluta J, Pyle LC, Nead KT, Wilf R, Li M, Mitra N, Weathers B, D'Andrea K, Almstrup K, Anson-Cartwright L, Benitez J, Brown CD, Chanock S, Chen C, Cortessis VK, Ferlin A, Foresta C, Gamulin M, Gietema JA, Grasso C, Greene MH, Grotmol T, Hamilton RJ, Haugen TB, Hauser R, Hildebrandt MAT, Johnson ME, Karlsson R, Kiemeney LA, Lessel D, Lothe RA, Loud JT, Loveday C, Martin-Gimeno P, Meijer C, Nsengimana J, Quinn DI, Rafnar T, Ramdas S, Richiardi L, Skotheim RI, Stefansson K, Turnbull C, Vaughn DJ, Wiklund F, Wu X, Yang D, Zheng T, Wells AD, Grant SFA, Rajpert-De Meyts E, Schwartz SM, Bishop DT, McGlynn KA, Kanetsky PA, Nathanson KL; Testicular Cancer Consortium. Nat Commun. 2021 Jul 23;12(1):4487. doi: 10.1038/s41467-021-24334-y. PMID: 34301922
A Multidisciplinary Collaborative Approach to Retinal Toxic Effects Screening for Dermatology Patients Taking Antimalarials. Fett N, Werth VP. JAMA Dermatol. 2021 Jul 28. doi: 10.1001/jamadermatol.2021.2699. Online ahead of print. PMID: 34319351
Subsetting the subsets: Heterogeneity and developmental relationships of T cells in human tumors. Alanio C, Wherry EJ. Sci Immunol. 2021 Jul 23;6(61):eabj3067. doi: 10.1126/sciimmunol.abj3067. PMID: 34301801
A statistical framework for differential pseudotime analysis with multiple single-cell RNA-seq samples. Hou W, Ji Z, Chen Z, Wherry EJ, Hicks SC, Ji H. bioRxiv. 2021 Jul 12:2021.07.10.451910. doi: 10.1101/2021.07.10.451910. Preprint. PMID: 34282418 PMCID: PMC8288148
Changes in Neuronal Activity in the Anterior Cingulate Cortex and Primary Somatosensory Cortex With Nonlinear Burst and Tonic Spinal Cord Stimulation. Quindlen-Hotek JC, Kent AR, De Anda P, Kartha S, Benison AM, Winkelstein BA. Neuromodulation. 2020 Jul;23(5):594-604. doi: 10.1111/ner.13116. Epub 2020 Feb 6. PMID: 32027444 PMCID: PMC7771032
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency. Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Mol Cell. 2021 Jul 28:S1097-2765(21)00587-6. PMID: 34358447
B cells in multiple sclerosis - from targeted depletion to immune reconstitution therapies. Cencioni MT, Mattoscio M, Magliozzi R, Bar-Or A, Muraro PA. Nat Rev Neurol. 2021 Jul;17(7):399-414. PMID: 34075251
ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements. Bermudez CA, Crespo MM, Shlobin OA, Cantu E, Mazurek JA, Levine D, Gutsche J, Kanwar M, Dellgren G, Bush EL, Heresi GA, Cypel M, Hadler R, Kolatis N, Franco V, Benvenuto L, Mooney J, Pipeling M, King C, Mannem H, Raman S, Knoop C, Douglas A, Mercier O. J Heart Lung Transplant. 2021 Jul 29:S1053-2498(21)02435-9. PMID: 34404570
Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition. Liu X, Verma A, Garcia G, Ramage H, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. medRxiv. 2021 Jul 21:2021.02.17.21251933. PMID: 33655282 PMCID: PMC7924307
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit. Hall MD, Anderson JM, Anderson A, Baker D, Bradner J, Brimacombe KR, Campbell EA, Corbett KS, Carter K, Cherry S, Chiang L, Cihlar T, de Wit E, Denison M, Disney M, Fletcher CV, Ford-Scheimer SL, Götte M, Grossman AC, Hayden FG, Hazuda DJ, Lanteri CA, Marston H, Mesecar AD, Moore S, Nwankwo JO, O'Rear J, Painter G, Singh Saikatendu K, Schiffer CA, Sheahan TP, Shi PY, Smyth HD, Sofia MJ, Weetall M, Weller SK, Whitley R, Fauci AS, Austin CP, Collins FS, Conley AJ, Davis MI. J Infect Dis. 2021 Jul 15;224(Supplement_1):S1-S21. PMID: 34111271 PMCID: PMC8280938
Morphologically malignant nodular fasciitis with CALD1-USP6 fusion. Papke DJ Jr, Oliveira AM, Chou MM, Fletcher CDM. Virchows Arch. 2021 Jul 2. doi: 10.1007/s00428-021-03149-8. PMID: 34213575
Plasma Nucleosomes Are Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome. Yehya N, Fazelinia H, Lawrence GG, Spruce LA, Mai MV, Worthen GS, Christie JD. Crit Care Med. 2021 Jul 1;49(7):1149-1158. PMID: 33729723
Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients. Shah P, Lowery E, Chaparro C, Visner G, Hempstead SE, Abraham J, Bhakta Z, Carroll M, Christon L, Danziger-Isakov L, Diamond JM, Lease E, Leonard J, Litvin M, Poole R, Vlahos F, Werchan C, Murray MA, Tallarico E, Faro A, Pilewski JM, Hachem RR. J Heart Lung Transplant. 2021 Jul;40(7):539-556. PMID: 34103223
Auditory and olfactory findings in patients with USH2A-related retinal degeneration-Findings at baseline from the rate of progression in USH2A-related retinal degeneration natural history study (RUSH2A). Iannaccone A, Brewer CC, Cheng P, Duncan JL, Maguire MG, Audo I, Ayala AR, Bernstein PS, Bidelman GM, Cheetham JK, Doty RL, Durham TA, Hufnagel RB, Myers MH, Stingl K, Zein WM; Foundation Fighting Blindness Consortium Investigator Group. Am J Med Genet A. 2021 Jul 30. PMID: 34331386
Effect of Esketamine Nasal Spray on Olfactory Function and Nasal Tolerability in Patients with Treatment-Resistant Depression: Results from Four Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Studies. Doty RL, Popova V, Wylie C, Fedgchin M, Daly E, Janik A, Ochs-Ross R, Lane R, Lim P, Cooper K, Melkote R, Jamieson C, Singh J, Drevets WC. CNS Drugs. 2021 Jul;35(7):781-794. PMID: 34235612 PMCID: PMC8310483

June 2021

Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV. Giron LB, Palmer CS, Liu Q, Yin X, Papasavvas E, Sharaf R, Etemad B, Damra M, Goldman AR, Tang HY, Johnston R, Mounzer K, Kostman JR, Tebas P, Landay A, Montaner LJ, Jacobson JM, Li JZ, Abdel-Mohsen M. Nat Commun. 2021 Jun 29;12(1):3922. PMID: 34188039
Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients. Giron LB, Dweep H, Yin X, Wang H, Damra M, Goldman AR, Gorman N, Palmer CS, Tang HY, Shaikh MW, Forsyth CB, Balk RA, Zilberstein NF, Liu Q, Kossenkov A, Keshavarzian A, Landay A, Abdel-Mohsen M. Front Immunol. 2021 Jun 9;12:686240. eCollection 2021. PMID: 34177935
Erratum for Adeniji et al., "COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions". Adeniji OS, Giron LB, Purwar M, Zilberstein NF, Kulkarni AJ, Shaikh MW, Balk RA, Moy JN, Forsyth CB, Liu Q, Dweep H, Kossenkov A, Weiner DB, Keshavarzian A, Landay A, Abdel-Mohsen M. mBio. 2021 Jun 8:e0124421. Online ahead of print. PMID: 34098736
Determinants of kidney transplant candidates' decision to accept organ donor intervention transplants and participate in post-transplant research: A conjoint analysis. Gordon EJ, Abt P, Lee J, Knopf E, Phillips C, Bermudez F, Krishnamurthi L, Karaca HS, Veatch R, Knight R, Conway PT, Dunn S, Reese PP. Clin Transplant. 2021 Jun;35(6):e14316. Epub 2021 May 2. PMID: 33844367
18F-Sodium Fluoride PET as a Diagnostic Modality for Metabolic, Autoimmune, and Osteogenic Bone Disorders: Cellular Mechanisms and Clinical Applications. Park PSU, Raynor WY, Sun Y, Werner TJ, Rajapakse CS, Alavi A. Int J Mol Sci. 2021 Jun 17;22(12):6504. PMID: 34204387
Expression of MRGPRX2 in skin mast cells of patients with maculopapular cutaneous mastocytosis. Deepak V, Komarow HD, Alblaihess AA, Carter MC, Metcalfe DD, Ali H. J Allergy Clin Immunol Pract. 2021 Jun 25:S2213-2198(21)00697-8. Online ahead of print. PMID: 34182161
Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis. Church ME, Ceja G, McGeehan M, Miller MC, Farias P, Sánchez MD, Swain GP, Assenmacher CA, Stopa EG, Vite CH, Bar-Or A, Alvarez JI. J Immunol. 2021 Jun 23:ji2000514. Online ahead of print. PMID: 34162727
The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients. Pyfrom S, Paneru B, Knox JJ, Cancro MP, Posso S, Buckner JH, Anguera MC. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2024624118. PMID: 34103397 PMCID: PMC8214693
Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances. Bar-Or A, Li R. Lancet Neurol. 2021 Jun;20(6):470-483. doi: 10.1016/S1474-4422(21)00063-6. Epub 2021 Apr 27. PMID: 33930317 Review.
TNF blockade uncouples toxicity from antitumor efficacy induced with CD40 chemoimmunotherapy. Stone ML, Lee J, Herrera VM, Graham K, Lee JW, Huffman A, Coho H, Tooker E, Myers MI, Giannone M, Li Y, Buckingham TH, Long KB, Beatty GL. JCI Insight. 2021 Jun 8:146314. Online ahead of print. PMID: 34101617
Serum Amyloid A Proteins and Their Impact on Metastasis and Immune Biology in Cancer. Lee J, Beatty GL. Cancers (Basel). 2021 Jun 25;13(13):3179. PMID: 34202272 Review.
Transcriptional regulation of T cell metabolism and metabolic control of T cell gene expression. Veliz K, Beier UH. Curr Opin Genet Dev. 2021 Jun 26;70:83-88. Online ahead of print. PMID: 34186442 Review.
Remodeling of the maternal gut microbiome during pregnancy is shaped by parity. Berry ASF, Pierdon MK, Misic AM, Sullivan MC, O'Brien K, Chen Y, Murray SJ, Ramharack LA, Baldassano RN, Parsons TD, Beiting DP. Microbiome. 2021 Jun 27;9(1):146. PMID: 34176489 PMCID: PMC8237508
Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs. Gui J, Zahedi F, Ortiz A, Cho C, Katlinski KV, Alicea-Torres K, Li J, Todd L, Zhang H, Beiting DP, Sander C, Kirkwood JM, Snow BE, Wakeham AC, Mak TW, Diehl JA, Koumenis C, Ryeom SW, Stanger BZ, Puré E, Gabrilovich DI, Fuchs SY. Nat Cancer. 2020 Jun;1(6):603-619. Epub 2020 May 25. PMID: 34124690 PMCID: PMC8194112
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML. Riedel SS, Lu C, Xie HM, Nestler K, Vermunt MW, Lenard A, Bennett L, Speck NA, Hanamura I, Lessard JA, Blobel GA, Garcia BA, Bernt KM. Mol Cell. 2021 Jun 3;81(11):2332-2348.e9. Epub 2021 May 10. PMID: 33974912
Integrative Multi-Omics Reveals Serum Markers of Tuberculosis in Advanced HIV. Krishnan S, Queiroz ATL, Gupta A, Gupte N, Bisson GP, Kumwenda J, Naidoo K, Mohapi L, Mave V, Mngqibisa R, Lama JR, Hosseinipour MC, Andrade BB, Karakousis PC. Front Immunol. 2021 Jun 8;12:676980. eCollection 2021. PMID: 34168648 PMCID: PMC8217878
Hematopoietic Stem Cell Transplantation Successfully Treats CD40LG Duplication. Sun D, Le Coz C, Bunin N, Romberg N. J Clin Immunol. 2021 Jun 22. . Online ahead of print. PMID: 34159508
The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients. Pyfrom S, Paneru B, Knox JJ, Cancro MP, Posso S, Buckner JH, Anguera MC. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2024624118. PMID: 34103397
A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury. Li C, Patel K, Tu Z, Yang X, Kulik L, Alawieh A, Allen P, Cheng Q, Wallace C, Kilkenny J, Kwon J, Gibney B, Cantu E, Sharma A, Pipkin M, Machuca T, Emtiazjoo A, Goddard M, Holers VM, Nadig S, Christie J, Tomlinson S, Atkinson C. Am J Transplant. 2021 Jun;21(6):2067-2078. Epub 2021 Feb 26. PMID: 33210808 PMCID: PMC8246004
Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure. Daghlas I, Karhunen V, Ray D, Zuber V, Burgess S, Tsao PS, Lynch JA, Lee KM, Voight BF, Chang KM, Baker EH, Damrauer SM, Howson JMM, Vujkovic M, Gill D. J Am Heart Assoc. 2021 Jun 29:e020331. Online ahead of print. PMID: 34184541
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease. Levin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM; VA Million Veteran Program. Circulation. 2021 Jun 18. Online ahead of print. PMID: 34139859
Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes. Khandelwal S, Barnes A, Rauova L, Sarkar A, Rux AH, Yarovoi SV, Zaitsev S, Lambris JD, Myoung SS, Johnson A, Lee GM, Duarte M, Poncz M, Arepally GM, Cines DB. Blood. 2021 Jun 29:blood.2020009487. Online ahead of print. PMID: 34189574
COVID-19 vaccination and immune thrombocytopenia. Pishko AM, Bussel JB, Cines DB. Nat Med. 2021 Jun 9. Online ahead of print. PMID: 34108715
SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. Cines DB, Bussel JB. N Engl J Med. 2021 Jun 10;384(23):2254-2256. Epub 2021 Apr 16. PMID: 33861524 PMCID: PMC8063912
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons. Sherrill-Mix S, Hwang Y, Roche AM, Glascock A, Weiss SR, Li Y, Haddad L, Deraska P, Monahan C, Kromer A, Graham-Wooten J, Taylor LJ, Abella BS, Ganguly A, Collman RG, Van Duyne GD, Bushman FD. Genome Biol. 2021 Jun 3;22(1):169. PMID: 34082799 PMCID: PMC8173101
Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel. Bouché M, Dong YC, Sheikh S, Taing K, Saxena D, Hsu JC, Chen MH, Salinas RD, Song H, Burdick JA, Dorsey J, Cormode DP. ACS Biomater Sci Eng. 2021 Jun 23. Online ahead of print. PMID: 34160196
Positive Long-Term Effects of Third Molar Extraction on Taste Function. Kim D, Doty RL. Chem Senses. 2021 Jun 23:bjab032. Online ahead of print. PMID: 34161573
Biopsy of the olfactory epithelium from the superior nasal septum: is it possible to obtain neurons without damaging olfaction? Garcia ECD, Luz LA, Anzolin LK, Barbosa da Silva JL, Doty RL, Pinna FR, Voegels RL, Fornazieri MA. Braz J Otorhinolaryngol. 2021 Jun 5:S1808-8694(21)00093-8. Online ahead of print. PMID: 34144902
Effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naïve adults living with HIV. Spitsin S, Pappa V, Kinder A, Evans DL, Rappaport J, Douglas SD. Medicine (Baltimore). 2021 Jun 11;100(23):e25313. PMID: 34114978 PMCID: PMC8202663
Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation. Toulmin SA, Bhadiadra C, Paris AJ, Lin JH, Katzen J, Basil MC, Morrisey EE, Worthen GS, Eisenlohr LC. Nat Commun. 2021 Jun 28;12(1):3993. PMID: 34183650
Urban residential tree canopy and perceived stress among pregnant women. Nguemeni Tiako MJ, South E, Shannon MM, McCarthy C, Meisel ZF, Elovitz MA, Burris HH. Environ Res. 2021 Jun 30:111620. Online ahead of print. PMID: 34216611
Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses. Uyanik B, Goloudina AR, Akbarali A, Grigorash BB, Petukhov AV, Singhal S, Eruslanov E, Chaloyard J, Lagorgette L, Hadi T, Baidyuk EV, Sakai H, Tessarollo L, Ryffel B, Mazur SJ, Lirussi F, Garrido C, Appella E, Demidov ON. Nat Commun. 2021 Jun 15;12(1):3622. PMID: 34131120 PMCID: PMC8206133
Budesonide Oral Suspension Improves Outcomes in Patients With Eosinophilic Esophagitis: Results from a Phase 3 Trial. Hirano I, Collins MH, Katzka DA, Mukkada VA, Falk GW, Morey R, Desai NK, Lan L, Williams J, Dellon ES. Clin Gastroenterol Hepatol. 2021 Jun 29:S1542-3565(21)00697-2. Online ahead of print. PMID: 34214677
Long-Term Treatment of Eosinophilic Esophagitis with Budesonide Oral Suspension. Dellon ES, Collins MH, Katzka DA, Mukkada VA, Falk GW, Morey R, Goodwin B, Eisner JD, Lan L, Desai NK, Williams J, Hirano I; ORBIT2/SHP621-302 investigators. Clin Gastroenterol Hepatol. 2021 Jun 25:S1542-3565(21)00684-4. Online ahead of print. PMID: 34182150
Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Ali Nabavizadeh S, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y. Nat Commun. 2021 Jun 8;12(1):3424. PMID: 34103524 PMCID: PMC8187342
A Systematic Review of the Potential Implication of Infectious Agents in Myasthenia Gravis. Leopardi V, Chang YM, Pham A, Luo J, Garden OA. Front Neurol. 2021 Jun 14;12:618021. eCollection 2021. PMID: 34194378 PMCID: PMC8236805
Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor. Uberoi A, Bartow-McKenney C, Zheng Q, Flowers L, Campbell A, Knight SAB, Chan N, Wei M, Lovins V, Bugayev J, Horwinski J, Bradley C, Meyer J, Crumrine D, Sutter CH, Elias P, Mauldin E, Sutter TR, Grice EA. Cell Host Microbe. 2021 Jun 29:S1931-3128(21)00239-0. Online ahead of print. PMID: 34214492
Early detection of SARS-CoV-2 and other infections in solid organ transplant recipients and household members using wearable devices. Keating BJ, Mukhtar EH, Elftmann ED, Eweje FR, Gao H, Ibrahim LI, Kathawate RG, Lee AC, Li EH, Moore KA, Nair N, Chaluvadi V, Reason J, Zanoni F, Honkala AT, Al-Ali AK, Abdullah Alrubaish F, Ahmad Al-Mozaini M, Al-Muhanna FA, Al-Romaih K, Goldfarb SB, Kellogg R, Kiryluk K, Kizilbash SJ, Kohut TJ, Kumar J, O'Connor MJ, Rand EB, Redfield RR, Rolnik B, Rossano J, Sanchez PG, Alavi A, Bahmani A, Bogu GK, Brooks AW, Metwally AA, Mishra T, Marks SD, Montgomery RA, Fishman JA, Amaral S, Jacobson PA, Wang M, Snyder MP. Transpl Int. 2021 Jun;34(6):1019-1031. Epub 2021 May 5. PMID: 33735480 PMCID: PMC8250335
Multivariable Dependence of Acoustic Contrast of Fluorocarbon and Xenon Microbubbles under Flow. Chattaraj R, Hammer DA, Lee D, Sehgal CM. Ultrasound Med Biol. 2021 Jun 7:S0301-5629(21)00204-0. Online ahead of print. PMID: 34112553
SARS-CoV-2 Seropositivity and Seroconversion in Patients Undergoing Active Cancer-Directed Therapy. Sun L, Surya S, Goodman NG, Le AN, Kelly G, Owoyemi O, Desai H, Zheng C, DeLuca S, Good ML, Hussain J, Jeffries SD, Kry YR, Kugler EM, Mansour M, Ndicu J, Osei-Akoto A, Prior T, Pundock SL, Varughese LA, Weaver J, Doucette A, Dudek S, Verma SS, Gouma S, Weirick ME, McAllister CM, Bange E, Gabriel P, Ritchie M, Rader DJ, Vonderheide RH, Schuchter LM, Verma A, Maillard I, Mamtani R, Hensley SE, Gross R, Wileyto EP, Huang AC, Maxwell KN, DeMichele A. JCO Oncol Pract. 2021 Jun 16:OP2100113. Online ahead of print. PMID: 34133219
An Egg-Derived Sulfated N-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines. Guthmiller JJ, Utset HA, Henry C, Li L, Zheng NY, Sun W, Costa Vieira M, Zost S, Huang M, Hensley SE, Cobey S, Palese P, Wilson PC. mBio. 2021 Jun 15:e0083821. Online ahead of print. PMID: 34126773
Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia. Myers RM, Li Y, Barz Leahy A, Barrett DM, Teachey DT, Callahan C, Fasano CC, Rheingold SR, DiNofia A, Wray L, Aplenc R, Baniewicz D, Liu H, Shaw PA, Pequignot E, Getz KD, Brogdon JL, Fesnak AD, Siegel DL, Davis MM, Bartoszek C, Lacey SF, Hexner EO, Chew A, Wertheim GB, Levine BL, June CH, Grupp SA, Maude SL. J Clin Oncol. 2021 Jun 22:JCO2003458. Online ahead of print. PMID: 34156874
SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms. Vazquez C, Swanson SE, Negatu SG, Dittmar M, Miller J, Ramage HR, Cherry S, Jurado KA. PLoS One. 2021 Jun 24;16(6):e0253089. eCollection 2021. PMID: 34166398
Cerebral Cavernous Malformation: From Mechanism to Therapy. Snellings DA, Hong CC, Ren AA, Lopez-Ramirez MA, Girard R, Srinath A, Marchuk DA, Ginsberg MH, Awad IA, Kahn ML. Circ Res. 2021 Jun 25;129(1):195-215. Epub 2021 Jun 24. PMID: 34166073
Maintenance of the human memory T cell repertoire by subset and tissue site. Miron M, Meng W, Rosenfeld AM, Dvorkin S, Poon MML, Lam N, Kumar BV, Louzoun Y, Luning Prak ET, Farber DL. Genome Med. 2021 Jun 14;13(1):100. PMID: 34127056 PMCID: PMC8204429
MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis. Slaff B, Radens CM, Jewell P, Jha A, Lahens NF, Grant GR, Thomas-Tikhonenko A, Lynch KW, Barash Y. Nat Commun. 2021 Jun 7;12(1):3353. PMID: 34099673 PMCID: PMC8184769
Deep learning to detect acute respiratory distress syndrome on chest radiographs: a retrospective study with external validation. Sjoding MW, Taylor D, Motyka J, Lee E, Co I, Claar D, McSparron JI, Ansari S, Kerlin MP, Reilly JP, Shashaty MGS, Anderson BJ, Jones TK, Drebin HM, Ittner CAG, Meyer NJ, Iwashyna TJ, Ward KR, Gillies CE. Lancet Digit Health. 2021 Jun;3(6):e340-e348. Epub 2021 Apr 20. PMID: 33893070 PMCID: PMC8182690
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV. Giron LB, Palmer CS, Liu Q, Yin X, Papasavvas E, Sharaf R, Etemad B, Damra M, Goldman AR, Tang HY, Johnston R, Mounzer K, Kostman JR, Tebas P, Landay A, Montaner LJ, Jacobson JM, Li JZ, Abdel-Mohsen M. Nat Commun. 2021 Jun 29;12(1):3922. PMID: 34188039
Myeloablative versus Reduced-Intensity Conditioning for Hematopoietic Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndromes-Long-Term Follow-Up of the BMT CTN 0901 Clinical Trial. Scott BL, Pasquini MC, Fei M, Fraser R, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick E, Fernandez HF, Soiffer RJ, Alyea E, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Hourigan CS, Gui G, Mendizabal A, Horowitz MM, Deeg HJ, Horwitz ME. Transplant Cell Ther. 2021 Jun;27(6):483.e1-483.e6. Epub 2021 Feb 26. PMID: 33775615 PMCID: PMC8217373
Do Corticosteroid Injections for the Treatment of Pain Influence the Efficacy of Adenovirus Vector-Based COVID-19 Vaccines? Lee H, Punt JA, Patel J, Stojanovic MP, Duszynski B, McCormick ZL; Spine Intervention Society’s Patient Safety Committee. Pain Med. 2021 Jun 4;22(6):1441-1464. PMID: 33839780 PMCID: PMC8083288
Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism. Abbey D, Conlon D, Rainville C, Elwyn S, Quiroz-Figueroa K, Billheimer J, Schultz DC, Hand NJ, Cherry S, Rader DJ. Clin Transl Sci. 2021 Jun 22. Online ahead of print. PMID: 34156146
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.Veturi Y, Lucas A, Bradford Y, Hui D, Dudek S, Theusch E, Verma A, Miller JE, Kullo I, Hakonarson H, Sleiman P, Schaid D, Stein CM, Edwards DRV, Feng Q, Wei WQ, Medina MW, Krauss RM, Hoffmann TJ, Risch N, Voight BF, Rader DJ, Ritchie MD. Nat Genet. 2021 Jun 17. Online ahead of print. PMID: 34140684
Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes. Khandelwal S, Barnes A, Rauova L, Sarkar A, Rux AH, Yarovoi SV, Zaitsev S, Lambris JD, Myoung SS, Johnson A, Lee GM, Duarte M, Poncz M, Arepally GM, Cines DB. Blood. 2021 Jun 29:blood.2020009487. Online ahead of print. PMID: 34189574
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML. Riedel SS, Lu C, Xie HM, Nestler K, Vermunt MW, Lenard A, Bennett L, Speck NA, Hanamura I, Lessard JA, Blobel GA, Garcia BA, Bernt KM. Mol Cell. 2021 Jun 3;81(11):2332-2348.e9. Epub 2021 May 10. PMID: 33974912
The Risk of Allergic Reaction to SARS-CoV-2 Vaccines and Recommended Evaluation and Management: A Systematic Review, Meta-analysis, GRADE Assessment, and International Consensus Approach. Greenhawt M, Abrams EM, Shaker M, Chu DK, Kahn D, Akin C, Alqurashi W, Arkwright P, Baldwin JL, Ben-Shoshan M, Bernstein J, Bingeman T, Blumchen K, Byrne A, Bognanni A, Campbell D, Campbell R, Chagla Z, Chan ES, Chan J, Comberiatti P, Dribin TE, Ellis AK, Fleischer DM, Fox A, Frischmeyer-Guerrerio PA, Gagnon R, Grayson MH, Horner CC, Hourihane J, Katelaris CH, Kim H, Kelso JM, Lang D, Ledford D, Levin M, Lieberman J, Loh R, Mack D, Mazer B, Mosnaim G, Munblit D, Mustafa SS, Nanda A, Oppenheimer J, Perrett KP, Ramsey A, Rank M, Robertson K, Shiek J, Spergel JM, Stukus D, Tang ML, Tracy JM, Turner PJ, Whalen-Browne A, Wallace D, Wang J, Wasserman S, Witty JK, Worm M, Vander Leek TK, Golden DB. J Allergy Clin Immunol Pract. 2021 Jun 18:S2213-2198(21)00671-1. Online ahead of print. PMID: 34153517 PMCID: PMC8248554
Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors. Arehart CH, Daya M, Campbell M, Boorgula MP, Rafaels N, Chavan S, David G, Hanifin J, Slifka MK, Gallo RL, Hata T, Schneider LC, Paller AS, Ong PY, Spergel JM, Guttman-Yassky E, Leung DYM, Beck LA, Gignoux CR, Mathias RA, Barnes KC. J Allergy Clin Immunol. 2021 Jun 7:S0091-6749(21)00895-2. Online ahead of print. PMID: 34111454
Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency. Magg T, Okano T, Koenig LM, Boehmer DFR, Schwartz SL, Inoue K, Heimall J, Licciardi F, Ley-Zaporozhan J, Ferdman RM, Caballero-Oteyza A, Park EN, Calderon BM, Dey D, Kanegane H, Cho K, Montin D, Reiter K, Griese M, Albert MH, Rohlfs M, Gray P, Walz C, Conn GL, Sullivan KE, Klein C, Morio T, Hauck F. Sci Immunol. 2021 Jun 18;6(60):eabf9564. PMID: 34145065
Distinct immune trajectories in patients with chromosome 22q11.2 deletion syndrome and immune-mediated diseases. Crowley TB, Campbell IM, Liebling EJ, Lambert MP, Levitt Katz LE, Heimall J, Bailey A, McGinn DE, McDonald McGinn DM, Sullivan KE. J Allergy Clin Immunol. 2021 Jun 16:S0091-6749(21)00939-8. Online ahead of print. PMID: 34144109
Mucosal Invariant T cells are Diminished in Very Early-Onset Inflammatory Bowel Disease. Dou Y, Maurer K, Conrad M, Patel T, Shraim R, Sullivan KE, Kelsen J. J Pediatr Gastroenterol Nutr. 2021 Jun 7. Online ahead of print. PMID: 34117197
Therapeutic options for CTLA-4 Insufficiency. Egg D, Rump IC, Mitsuiki N, Rojas-Restrepo J, Maccari ME, Schwab C, Gabrysch A, Warnatz K, Goldacker S, Patiño V, Wolff D, Okada S, Hayakawa S, Shikama Y, Kanda K, Imai K, Sotomatsu M, Kuwashima M, Kamiya T, Morio T, Matsumoto K, Mori T, Yoshimoto Y, Dybedal I, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Lorenz HM, Sullivan KE, Heimall J, Moutschen M, Litzman J, Recher M, Albert MH, Hauck F, Seneviratne S, Schmid JP, Kolios A, Unglik G, Klemann C, Snapper S, Giulino-Roth L, Svaton M, Platt CD, Hambleton S, Neth O, Gosse G, Reinsch S, Holzinger D, Kim YJ, Bakhtiar S, Atschekzei F, Schmidt R, Sogkas G, Chandrakasan S, Rae W, Derfalvi B, Marquart HV, Ozen A, Kiykim A, Karakoc-Aydiner E, Králíčková P, de Bree G, Kiritsi D, Seidel MG, Kobbe R, Dantzer J, Alsina L, Armangue T, Lougaris V, Agyeman P, Nyström S, Buchbinder D, Arkwright PD, Grimbacher B. J Allergy Clin Immunol. 2021 Jun 7:S0091-6749(21)00891-5. Online ahead of print. PMID: 34111452
Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia. Li Y, Yang W, Devidas M, Winter SS, Kesserwan C, Yang W, Dunsmore KP, Smith C, Qian M, Zhao X, Zhang R, Gastier-Foster JM, Raetz EA, Carroll WL, Li C, Liu PP, Rabin KR, Sanda T, Mullighan CG, Nichols KE, Evans WE, Pui CH, Hunger SP, Teachey DT, Relling MV, Loh ML, Yang JJ. J Clin Invest. 2021 Jun 24:147898. Online ahead of print. PMID: 34166225
Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia. Myers RM, Li Y, Barz Leahy A, Barrett DM, Teachey DT, Callahan C, Fasano CC, Rheingold SR, DiNofia A, Wray L, Aplenc R, Baniewicz D, Liu H, Shaw PA, Pequignot E, Getz KD, Brogdon JL, Fesnak AD, Siegel DL, Davis MM, Bartoszek C, Lacey SF, Hexner EO, Chew A, Wertheim GB, Levine BL, June CH, Grupp SA, Maude SL. J Clin Oncol. 2021 Jun 22:JCO2003458. Online ahead of print. PMID: 34156874
Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection. Schultz DC, Johnson RM, Ayyanathan K, Miller J, Whig K, Kamalia B, Dittmar M, Weston S, Hammond HL, Dillen C, Castellana L, Lee JS, Li M, Lee E, Constant S, Ferrer M, Thaiss CA, Frieman MB, Cherry S. bioRxiv. 2021 Jun 24:2021.06.24.449811. Preprint. PMID: 34189531 PMCID: PMC8240684
Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts. Schulz L, Torres-Diz M, Cortés-López M, Hayer KE, Asnani M, Tasian SK, Barash Y, Sotillo E, Zarnack K, König J, Thomas-Tikhonenko A. Genome Biol. 2021 Jun 28;22(1):190. PMID: 34183059 PMCID: PMC8240250
Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling. Altshuler PJ, Schiazza AR, Luo L, Helmers MR, Chhay B, Han JJ, Hu R, Herbst DA, Tsourkas A, Cheng Z, Atluri P. Adv Ther (Weinh). 2021 Jun;4(6):2100036. Epub 2021 Apr 23. PMID: 34179348 PMCID: PMC8225225
Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis. Vukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N; GRADS Investigators. Eur Respir J. 2021 Jun 3:2002950. PMID: 34083402

May 2021

Prevalence of asthma in hospitalized and non-hospitalized children with COVID-19. Floyd GC, Dudley JW, Xiao R, Feudtner C, Taquechel K, Miller K, Henrickson SE, Hill DA, Kenyon CC. J Allergy Clin Immunol Pract. 2021 May;9(5):2077-2079.e2. doi: 10.1016/j.jaip.2021.02.038. PMID: 33676051
B-cell maturation antigen chimeric antigen receptor T-cell re-expansion in a patient with myeloma following salvage programmed cell death protein 1 inhibitor-based combination therapy. Bernabei L, Tian L, Garfall AL, Melenhorst JJ, Lacey SF, Stadtmauer EA, Vogl DT, Gonzalez VE, Plesa G, Young RM, Waxman A, Levine BL, June CH, Milone MC, Cohen AD. Br J Haematol. 2021 May;193(4):851-855. PMID: 33713436
IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity. Garcia de Mattos Barbosa M, Liu H, Huynh D, Shelley G, Keller ET, Emmer BT, Sherman EJ, Ginsburg D, Kennedy AA, Tai AW, Wobus CE, Mirabelli C, Lanigan TM, Samaniego M, Meng W, Rosenfeld AM, Luning Prak ET, Platt JL, Cascalho M. JCI Insight. 2021 Mar 26:147386. doi: 10.1172/jci.insight.147386. Online ahead of print. PMID: 33769311
ANGPTL3 Inhibition With Evinacumab Results in Faster Clearance of IDL and LDL apoB in Patients With Homozygous Familial Hypercholesterolemia. Reeskamp LF, Millar JS, Wu L, Jansen H, van Harskamp D, Schierbeek H, Gipe DA, Rader DJ, Dallinga-Thie GM, Hovingh GK, Cuchel M. Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1753-1759. Online ahead of print. PMID: 33691480
Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization. Chompunud Na Ayudhya C, Amponnawarat A, Ali H. Int J Mol Sci. 2021 May 18;22(10):5318. doi: 10.3390/ijms22105318. PMID: 34070125
Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease. Roy S, Chompunud Na Ayudhya C, Thapaliya M, Deepak V, Ali H. J Allergy Clin Immunol. 2021 May 4:S0091-6749(21)00721-1. doi: 10.1016/j.jaci.2021.03.049. Online ahead of print. PMID: 33957166
A n interdomain helix in IRE1α mediates the conformational change required for the sensor's activation. Ricci D, Tutton S, Marrocco I, Ying M, Blumenthal D, Eletto D, Vargas J, Boyle S, Fazelinia H, Qian L, Suresh K, Taylor D, Paton JC, Paton AW, Anthony Tang CH, Andrew Hu CC, Radhakrishnan R, Gidalevitz T, Argon Y. J Biol Chem. 2021 May 14:100781. doi: 10.1016/j.jbc.2021.100781. Online ahead of print. PMID: 34000298 PMCID: PMC8203841
Factor IX assay discrepancies in the setting of liver gene therapy using a hyperfunctional variant factor IX-Padua . Robinson MM, George LA, Carr ME, Samelson-Jones BJ, Arruda VR, Murphy JE, Rybin D, Rupon J, High KA, Tiefenbacher S. J Thromb Haemost. 2021 May;19(5):1212-1218. doi: 10.1111/jth.15281. Epub 2021 Mar 28. PMID: 33636038 PMCID: PMC8130854
Examining cognitive speed and accuracy dysfunction in youth and young adults with pediatric-onset multiple sclerosis using a computerized neurocognitive battery. Barlow-Krelina E, Fabri TL, O'Mahony J, Gur RC, Gur RE, De Somma E, Bolongaita L, Dunn CL, Bacchus M, Yeh EA, Marrie RA, Bar-Or A, Banwell BL, Till C. Neuropsychology. 2021 May;35(4):388-398. doi: 10.1037/neu0000729. PMID: 34043389
Author Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study.
Bar-Or A, Herman A, Stokmaier D. Neurology. 2021 May 4;96(18):870. doi: 10.1212/WNL.0000000000011868. PMID: 34032593 No abstract available.
Artificial intelligence extension of the OSCAR-IB criteria. Petzold A, Albrecht P, Balcer L, Bekkers E, Brandt AU, Calabresi PA, Deborah OG, Graves JS, Green A, Keane PA, Nij Bijvank JA, Sander JW, Paul F, Saidha S, Villoslada P, Wagner SK, Yeh EA; IMSVISUAL, ERN-EYE Consortium. Ann Clin Transl Neurol. 2021 May 19. doi: 10.1002/acn3.51320. Online ahead of print. PMID: 34008926 Review.
Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19). Anderson EM, Diorio C, Goodwin EC, McNerney KO, Weirick ME, Gouma S, Bolton MJ, Arevalo CP, Chase J, Hicks P, Manzoni TB, Baxter AE, Andrea KP, Burudpakdee C, Lee JH, Vella LA, Henrickson SE, Harris RM, Wherry EJ, Bates P, Bassiri H, Behrens EM, Teachey DT, Hensley SE. J Pediatric Infect Dis Soc. 2021 May 28;10(5):669-673. doi: 10.1093/jpids/piaa161. PMID: 33263756 PMCID: PMC7799010
Amelioration of Murine Macrophage Activation Syndrome by Monomethyl Fumarate in Both a Heme Oxygenase 1-Dependent and Heme Oxygenase 1-Independent Manner. Biswas C, Chu N, Burn TN, Kreiger PA, Behrens EM. Arthritis Rheumatol. 2021 May;73(5):885-895. doi: 10.1002/art.41591. Epub 2021 Mar 25. PMID: 33191652 PMCID: PMC8084959
Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies. Lu Z, Ortiz A, Verginadis II, Peck AR, Zahedi F, Cho C, Yu P, DeRita RM, Zhang H, Kubanoff R, Sun Y, Yaspan AT, Krespan E, Beiting DP, Radaelli E, Ryeom SW, Diehl JA, Rui H, Koumenis C, Fuchs SY. J Clin Invest. 2021 May 17;131(10):e144225. doi: 10.1172/JCI144225. PMID: 33998600 PMCID: PMC8121529
Inhibition of Gamma-secretase activity without interfering in Notch signaling decreases inflammatory response in patients with cutaneous leishmaniasis. Nascimento MT, Franca M, Carvalho AM, Amorim C, Peixoto F, Beiting D, Scott P, Carvalho EM, Carvalho LP. Emerg Microbes Infect. 2021 May 19:1-20. doi: 10.1080/22221751.2021.1932608. Online ahead of print. PMID: 34009107
Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells. McLane LM, Ngiow SF, Chen Z, Attanasio J, Manne S, Ruthel G, Wu JE, Staupe RP, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Freedman BD, Betts MR, Wherry EJ. Cell Rep. 2021 May 11;35(6):109120. doi: 10.1016/j.celrep.2021.109120. PMID: 33979613 PMCID: PMC8195461
Engineering three-dimensional genome folding. Zhang D, Lam J, Blobel GA. Nat Genet. 2021 May;53(5):602-611. doi: 10.1038/s41588-021-00860-9. Epub 2021 May 6. PMID: 33958782 Review.
Remodeling of the Posterior Cerebral Artery P1-Segment after Pipeline Flow Diverter Treatment of Posterior Communicating Artery Aneurysms . Litao MS, Burkhardt JK, Tanweer O, Raz E, Huang P, Becske T, Shapiro M, Riina H, Nelson PK. Neurol Int. 2021 May 7;13(2):195-201. doi: 10.3390/neurolint13020020. PMID: 34066972
Postmarket American Experience With Woven EndoBridge Device: Adjudicated Multicenter Case Series. Cherian J, Chen SR, Puri A, Vakharia K, Levy E, Eshraghi S, Howard BM, Tong FC, Cawley CM, Gross B, Alexander MD, Grandhi R, Srinivasan VM, Burkhardt JK, Johnson JN, Kan P. Neurosurgery. 2021 May 14:nyab158. doi: 10.1093/neuros/nyab158. Online ahead of print. PMID: 33989398
Flared non-flow diverting ends of the FRED flow diverter for cerebral aneurysms facilitate device anchoring at the arterial bifurcation. Burkhardt JK, McGuire LS, Griessenauer CJ. Neuroradiol J. 2021 May 4:19714009211013508. doi: 10.1177/19714009211013508. Online ahead of print. PMID: 33942661
Peel Learning for Pathway-Related Outcome Prediction. Li Y, Wang F, Yan M, Cantu E, Yang FN, Rao H, Feng R. Bioinformatics. 2021 May 27:btab402. doi: 10.1093/bioinformatics/btab402. Online ahead of print. PMID: 34042937
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Du M, Garcia JGN, Christie JD, Xin J, Cai G, Meyer NJ, Zhu Z, Yuan Q, Zhang Z, Su L, Shen S, Dong X, Li H, Hutchinson JN, Tejera P, Lin X, Wang M, Chen F, Christiani DC. Intensive Care Med. 2021 May 25:1-11. doi: 10.1007/s00134-021-06410-5. Online ahead of print. PMID: 34032881
The Supportive Care Needs of Primary Caregivers of Lung Transplant Candidates. Pawlow PC, Blumenthal NP, Christie JD, Matura LA, Aryal S, Ersek M. J Pain Symptom Manage. 2021 May 13:S0885-3924(21)00330-4. doi: 10.1016/j.jpainsymman.2021.05.004. Online ahead of print. PMID: 33992758
Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program. Song RJ, Ho YL, Schubert P, Park Y, Posner D, Lord EM, Costa L, Gerlovin H, Kurgansky KE, Anglin-Foote T, DuVall S, Huffman JE, Pyarajan S, Beckham JC, Chang KM, Liao KP, Djousse L, Gagnon DR, Whitbourne SB, Ramoni R, Muralidhar S, Tsao PS, O'Donnell CJ, Gaziano JM, Casas JP, Cho K; VA Million Veteran Program COVID-19 Science Initiative. PLoS One. 2021 May 13;16(5):e0251651. doi: 10.1371/journal.pone.0251651. eCollection 2021. PMID: 33984066 PMCID: PMC8118298
Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns. Gargano D, Appanna R, Santonicola A, De Bartolomeis F, Stellato C, Cianferoni A, Casolaro V, Iovino P. Nutrients. 2021 May 13;13(5):1638. doi: 10.3390/nu13051638. PMID: 34068047 PMCID: PMC8152468
Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus. Ma C, Schoepfer AM, Safroneeva E; COREOS Collaborators. Gastroenterology. 2021 May 19:S0016-5085(21)03020-1. doi: 10.1053/j.gastro.2021.04.080. Online ahead of print. PMID: 34022180
Food protein-induced enterocolitis syndrome epidemiology. Cianferoni A. Ann Allergy Asthma Immunol. 2021 May;126(5):469-477. doi: 10.1016/j.anai.2021.02.006. Epub 2021 Feb 16. PMID: 33607250
Alpha-defensins: risk factor for thrombosis in COVID-19 infection. Abdeen S, Bdeir K, Abu-Fanne R, Maraga E, Higazi M, Khurram N, Feldman M, Deshpande C, Litzky LA, Heyman SN, Montone KT, Cines DB, Higazi AA. Br J Haematol. 2021 May 30. doi: 10.1111/bjh.17503. Online ahead of print. PMID: 34053084
Precision targeting of the plasminogen activator inhibitor-1 mechanism increases efficacy of fibrinolytic therapy in empyema. Florova G, Girard RA, Azghani AO, Sarva K, Buchanan A, Karandashova S, DeVera CJ, Morris D, Chamiso M, Koenig K, Cines DB, Idell S, Komissarov AA. Physiol Rep. 2021 May;9(9):e14861. doi: 10.14814/phy2.14861. PMID: 33991465
An integrated self-powered 3D printed sample concentrator for highly sensitive molecular detection of HIV in whole blood at the point of care. Kadimisetty K , Yin K , Roche AM , Yi Y , Bushman FD , Collman RG , Gross R , Feng L , Liu C .Analyst. 2021 May 21;146(10):3234-3241. doi: 10.1039/d0an02482a. Epub 2021 Apr 8.PMID: 33999045
Rengasvirus, a Circular Replication-Associated Protein-Encoding Single-Stranded DNA Virus-Related Genome That Is a Common Contaminant in Metagenomic Data. Keeler EL, Taylor LJ, Abbas A, Collman RG, Bushman FD. Microbiol Resour Announc. 2021 May 6;10(18):e00273-21. doi: 10.1128/MRA.00273-21. PMID: 33958399 PMCID: PMC8103869
Detecting and Monitoring Hydrogels with Medical Imaging. Dong YC, Bouché M, Uman S, Burdick JA, Cormode DP. ACS Biomater Sci Eng. 2021 May 12. doi: 10.1021/acsbiomaterials.0c01547. Online ahead of print. PMID: 33979137
In Vivo Molecular K-Edge Imaging of Atherosclerotic Plaque Using Photon-counting CT. Si-Mohamed SA, Sigovan M, Hsu JC, Tatard-Leitman V, Chalabreysse L, Naha PC, Garrivier T, Dessouky R, Carnaru M, Boussel L, Cormode DP, Douek PC. Radiology. 2021 May 4:203968. doi: 10.1148/radiol.2021203968. Online ahead of print. PMID: 33944628
Preclinical development of plant-based oral immune modulatory therapy for haemophilia B . Srinivasan A, Herzog RW, Khan I, Sherman A, Bertolini T, Wynn T, Daniell H. Plant Biotechnol J. 2021 May 5. doi: 10.1111/pbi.13608. Online ahead of print. PMID: 33949086
Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Cohen JB, Yang W, Li L, Zhang X, Zheng Z, Orlandi P, Bansal N, Deo R, Lash JP, Rahman M, He J, Shafi T, Chen J, Cohen DL, Matsushita K, Shlipak MG, Wolf M, Go AS, Feldman HI; CRIC Study Investigators. Am J Kidney Dis. 2021 May 27:S0272-6386(21)00629-6. doi: 10.1053/j.ajkd.2021.03.021. Online ahead of print. PMID: 34052355
The "Shocking" Reality of ICD Therapies. Deo R, Pothineni NVK. J Am Coll Cardiol. 2021 May 25;77(20):2463-2465. doi: 10.1016/j.jacc.2021.04.019. PMID: 34016258
Universal HbA1c screening and gestational diabetes: a comparison with clinical risk factors. Bender W, McCarthy C, Elovitz M, Parry S, Durnwald C. J Matern Fetal Neonatal Med. 2021 May 27:1-7. doi: 10.1080/14767058.2021.1914578. Online ahead of print. PMID: 34044736
Adrenalitis and anasarca in idiopathic multicentric Castleman's disease. Chen LYC, Skinnider BF, Wilson D, Fajgenbaum DC. Lancet. 2021 May 8;397(10286):1749. doi: 10.1016/S0140-6736(21)00674-7. PMID: 33965090
Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis. Safroneeva E, Pan Z, King E, Martin LJ, Collins MH, Yang GY, Capocelli KE, Arva NC, Abonia JP, Atkins D, Bonis PA, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Leung J, Menard-Katcher PA, Mukkada VA, Schoepfer AM, Spergel JM, Wershil BK, Rothenberg ME, Aceves SS, Furuta GT; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Clin Gastroenterol Hepatol. 2021 May 29:S1542-3565(21)00588-7. doi: 10.1016/j.cgh.2021.05.049. Online ahead of print. PMID: 34062314
Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus. Ma C, Schoepfer AM, Safroneeva E; COREOS Collaborators. Gastroenterology. 2021 May 19:S0016-5085(21)03020-1. doi: 10.1053/j.gastro.2021.04.080. Online ahead of print. PMID: 34022180
Dichotomous and stable gamma delta T-cell number and function in healthy individuals. Ou L, Wang H, Liu Q, Zhang J, Lu H, Luo L, Shi C, Lin S, Dong L, Guo Y, Huang L, Zhu J, Yin X, Huang AC, Karakousis G, Schuchter L, Amaravadi R, Zheng C, Fan Y, Guo W, Xu X. J Immunother Cancer. 2021 May;9(5):e002274. doi: 10.1136/jitc-2020-002274. PMID: 34011536 PMCID: PMC8137237
Microbial Sharing between Pediatric Patients and Therapy Dogs during Hospital Animal-Assisted Intervention Programs. Dalton KR, Ruble K, Redding LE, Morris DO, Mueller NT, Thorpe RJ Jr, Agnew J, Carroll KC, Planet PJ, Rubenstein RC, Chen AR, Grice EA, Davis MF. Microorganisms. 2021 May 13;9(5):1054. doi: 10.3390/microorganisms9051054. PMID: 34068292 PMCID: PMC8153335
Insights into the skin microbiome of sickle cell disease leg ulcers. Byeon J, Blizinsky KD, Persaud A, Findley K, Lee JJ, Buscetta AJ, You S, Bittinger K, Minniti CP, Bonham VL, Grice EA. Wound Repair Regen. 2021 May 8. doi: 10.1111/wrr.12924. Online ahead of print. PMID: 33964094
A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen. Hoare A, Wang H, Meethil A, Abusleme L, Hong BY, Moutsopoulos NM, Marsh PD, Hajishengallis G, Diaz PI. ISME J. 2021 May;15(5):1490-1504. doi: 10.1038/s41396-020-00865-y. Epub 2020 Dec 28. PMID: 33372193 PMCID: PMC8115154
Successful Recanalization of Complete Bronchus Intermedius Stenosis after Lung Transplantation Guided by Intraprocedural Computed Tomographic Imaging. Ma KC, DiBardino DM, Haas AR. Ann Am Thorac Soc. 2021 May;18(5):889-892. doi: 10.1513/AnnalsATS.202006-633CC. PMID: 33929308
A new perspective on mesenchymal-immune interactions in adipose tissue. Jimenez MT, Michieletto MF, Henao-Mejia J. Trends Immunol. 2021 May;42(5):375-388. doi: 10.1016/j.it.2021.03.001. Epub 2021 Apr 10. PMID: 33849777 PMCID: PMC8202037
Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory. Morrison TA, Hudson WH, Chisolm DA, Kanno Y, Shih HY, Ahmed R, Henao-Mejia J, Hafner M, O'Shea JJ. Cold Spring Harb Perspect Biol. 2021 May 17:a037952. doi: 10.1101/cshperspect.a037952. Online ahead of print. PMID: 34001528
CD8⁺ T cells contribute to survival in patients with COVID-19 and hematologic cancer. Bange EM, Han NA, Wileyto P, Kim JY, Gouma S, Robinson J, Greenplate AR, Hwee MA, Porterfield F, Owoyemi O, Naik K, Zheng C, Galantino M, Weisman AR, Ittner CAG, Kugler EM, Baxter AE, Oniyide O, Agyekum RS, Dunn TG, Jones TK, Giannini HM, Weirick ME, McAllister CM, Babady NE, Kumar A, Widman AJ, DeWolf S, Boutemine SR, Roberts C, Budzik KR, Tollett S, Wright C, Perloff T, Sun L, Mathew D, Giles JR, Oldridge DA, Wu JE, Alanio C, Adamski S, Garfall AL, Vella LA, Kerr SJ, Cohen JV, Oyer RA, Massa R, Maillard IP, Maxwell KN, Reilly JP, Maslak PG, Vonderheide RH, Wolchok JD, Hensley SE, Wherry EJ, Meyer NJ, DeMichele AM, Vardhana SA, Mamtani R, Huang AC. Nat Med. 2021 May 20. doi: 10.1038/s41591-021-01386-7. Online ahead of print. PMID: 34017137
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults. Pan YG, Aiamkitsumrit B, Bartolo L, Wang Y, Lavery C, Marc A, Holec PV, Rappazzo CG, Eilola T, Gimotty PA, Hensley SE, Antia R, Zarnitsyna VI, Birnbaum ME, Su LF. Immunity. 2021 May 17:S1074-7613(21)00185-0. doi: 10.1016/j.immuni.2021.04.023. Online ahead of print. PMID: 34004140 PMCID: PMC8192456
Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19 . Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles J, Wu JE, Chen Z, Huang YJ, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ. bioRxiv. 2021 May 3:2021.05.01.442279. doi: 10.1101/2021.05.01.442279. Preprint. PMID: 33972943 PMCID: PMC8109205
One march, many paths: Insights into allergic march trajectories. Gabryszewski SJ, Hill DA. Ann Allergy Asthma Immunol. 2021 May 7:S1081-1206(21)00344-6. doi: 10.1016/j.anai.2021.04.036. Online ahead of print. PMID: 33971364
Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma. Durgin JS, Henderson F Jr, Nasrallah MP, Mohan S, Wang S, Lacey SF, Melenhorst JJ, Desai AS, Lee JYK, Maus MV, June CH, Brem S, O'Connor RS, Binder Z, O'Rourke DM. Front Oncol. 2021 May 7;11:669071. doi: 10.3389/fonc.2021.669071. eCollection 2021. PMID: 34026647 PMCID: PMC8138201
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells. Bai Z, Lundh S, Kim D, Woodhouse S, Barrett DM, Myers RM, Grupp SA, Maus MV, June CH, Camara PG, Melenhorst JJ, Fan R. J Immunother Cancer. 2021 May;9(5):e002328. doi: 10.1136/jitc-2020-002328. PMID: 34006631 PMCID: PMC8137188
Response to "Is Male Gender Associated with Increased Liver-related Mortality in Primary Biliary Cholangitis and Cirrhosis?". John BV, Deng Y, Martin P, Levy C, Taddei TH, Kaplan DE, Dahman B. Hepatology. 2021 May 22. doi: 10.1002/hep.31917. Online ahead of print. PMID: 34021933
Ursodeoxycholic Acid Response Is Associated With Reduced Mortality in Primary Biliary Cholangitis With Compensated Cirrhosis. John BV, Khakoo NS, Schwartz KB, Aitchenson G, Levy C, Dahman B, Deng Y, Goldberg DS, Martin P, Kaplan DE, Taddei TH. Am J Gastroenterol. 2021 May 13. doi: 10.14309/ajg.0000000000001280. Online ahead of print. PMID: 33989225
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. Pazoki R, Vujkovic M, Elliott J, Evangelou E, Gill D, Ghanbari M, van der Most PJ, Pinto RC, Wielscher M, Farlik M, Zuber V, de Knegt RJ, Snieder H, Uitterlinden AG; Lifelines Cohort Study, Lynch JA, Jiang X, Said S, Kaplan DE, Lee KM, Serper M, Carr RM, Tsao PS, Atkinson SR, Dehghan A, Tzoulaki I, Ikram MA, Herzig KH, Järvelin MR, Alizadeh BZ, O'Donnell CJ, Saleheen D, Voight BF, Chang KM, Thursz MR, Elliott P; VA Million Veteran Program. Nat Commun. 2021 May 10;12(1):2579. doi: 10.1038/s41467-021-22338-2. PMID: 33972514 PMCID: PMC8110798
Response to Lleo and Hirschfield. John BV, Dahman B, Taddei TH, Levy C, Kaplan DE. Hepatology. 2021 May 3. doi: 10.1002/hep.31876. Online ahead of print. PMID: 33942361

April 2021

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Cummins KD, Lee YG, Pajarillo R, Chun I, Shyu A, Highfill SL, Price A, Zhao L, Peng L, Granda B, Ramones M, Lu XM, Christian DA, Perazzelli J, Lacey SF, Roy NH, Burkhardt JK, Colomb F, Damra M, Abdel-Mohsen M, Liu T, Liu D, Standley DM, Young RM, Brogdon JL, Grupp SA, June CH, Maude SL, Gill S, Ruella M. Nat Med. 2021 Apr 22. doi: 10.1038/s41591-021-01326-5. Online ahead of print. PMID: 33888899
COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions. Adeniji OS, Giron LB, Purwar M, Zilberstein NF, Kulkarni AJ, Shaikh MW, Balk RA, Moy JN, Forsyth CB, Liu Q, Dweep H, Kossenkov A, Weiner DB, Keshavarzian A, Landay A, Abdel-Mohsen M. mBio. 2021 Apr 20;12(2):e00281-21. doi: 10.1128/mBio.00281-21.
PMID: 33879594
STARCH SYNTHASE5, a Noncanonical Starch Synthase-Like Protein, Promotes Starch Granule Initiation in Arabidopsis. Abt MR, Pfister B, Sharma M, Eicke S, Bürgy L, Neale I, Seung D, Zeeman SC. Plant Cell. 2020 Aug 3;32(8):2543-2565. doi: 10.1105/tpc.19.00946. PMID: 33822996
Living Donor Liver Transplantation: Is Recipient Age a Barrier? Abu-Gazala S, Abt PL. Liver Transpl. 2021 Apr 27. doi: 10.1002/lt.26085. Online ahead of print. PMID: 33905597
Occult Hepatocellular Carcinoma Associated with Transjugular Intrahepatic Portosystemic Shunts in Liver Transplant Recipients. Krumeich LN, Mancinelli J, Cucchiara A, Eddinger K, Aufhauser D, Goldberg DW, Siegelman ES, Rosen M, Reddy KR, Hoteit M, Furth EE, Olthoff KM, Shaked A, Levine M, Abt P. Liver Transpl. 2021 Apr 14. doi: 10.1002/lt.26073. Online ahead of print. PMID: 33853207
Determinants of kidney transplant candidates' decision to accept organ donor intervention transplants and participate in post-transplant research: A conjoint analysis. Gordon EJ, Abt P, Lee J, Knopf E, Phillips C, Bermudez F, Krishnamurthi L, Karaca HS, Veatch R, Knight R, Conway PT, Dunn S, Reese PP. Clin Transplant. 2021 Apr 12:e14316. doi: 10.1111/ctr.14316. Online ahead of print. PMID: 33844367
A response to Kong et al.'s January 2021 article "Cannabinoids in dermatologic surgery". Abdalla T, Lytvyn Y, McDonald KA, Mufti A, Alavi A. J Am Acad Dermatol. 2021 Apr 26:S0190-9622(21)00912-9. doi: 10.1016/j.jaad.2021.04.068. Online ahead of print. PMID: 33915241
Coexistence of Hidradenitis Suppurativa and Steatocystoma Multiplex; Is It a New Variant of Hidradenitis Suppurativa? Fletcher J, Posso-De Los Rios C, Jambrosic J, Alavi A. J Cutan Med Surg. 2021 Apr 28:12034754211010145. doi: 10.1177/12034754211010145. Online ahead of print. PMID: 33908804
National Marrow Donor Program-Sponsored Multicenter, Phase II Trial of HLA-Mismatched Unrelated Donor Bone Marrow Transplantation Using Post-Transplant Cyclophosphamide. Shaw BE, Jimenez-Jimenez AM, Burns LJ, Logan BR, Khimani F, Shaffer BC, Shah NN, Mussetter A, Tang XY, McCarty JM, Alavi A, Farhadfar N, Jamieson K, Hardy NM, Choe H, Ambinder RF, Anasetti C, Perales MA, Spellman SR, Howard A, Komanduri KV, Luznik L, Norkin M, Pidala JA, Ratanatharathorn V, Confer DL, Devine SM, Horowitz MM, Bolaños-Meade J. J Clin Oncol. 2021 Apr 27:JCO2003502. doi: 10.1200/JCO.20.03502. Online ahead of print. PMID: 33905264
Carotid artery molecular calcification assessed by [¹⁸F]fluoride PET/CT: correlation with cardiovascular and thromboembolic risk factors. Castro SA, Muser D, Lee H, Hancin EC, Borja AJ, Acosta O, Werner TJ, Thomassen A, Constantinescu C, Høilund-Carlsen PF, Alavi A. Eur Radiol. 2021 Apr 17. doi: 10.1007/s00330-021-07917-7. Online ahead of print.
PMID: 33866386
Wound Bed Preparation 2021. Sibbald RG, Elliott JA, Persaud-Jaimangal R, Goodman L, Armstrong DG, Harley C, Coelho S, Xi N, Evans R, Mayer DO, Zhao X, Heil J, Kotru B, Delmore B, LeBlanc K, Ayello EA, Smart H, Tariq G, Alavi A, Somayaji R. Adv Skin Wound Care. 2021 Apr 1;34(4):183-195. doi: 10.1097/01.ASW.0000733724.87630.d6. PMID: 33739948
Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs. Ali H. Curr Opin Immunol. 2021 Apr 12;72:65-71. doi: 10.1016/j.coi.2021.03.011. Online ahead of print. PMID: 33857758 Review.
Disruption of the blood-brain barrier in 22q11.2 deletion syndrome. Crockett AM, Ryan SK, Vásquez AH, Canning C, Kanyuch N, Kebir H, Ceja G, Gesualdi J, Zackai E, McDonald-McGinn D, Viaene A, Kapoor R, Benallegue N, Gur R, Anderson SA, Alvarez JI. Brain. 2021 Apr 20:awab055. doi: 10.1093/brain/awab055. Online ahead of print. PMID: 33876226
Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances. Bar-Or A, Li R. Lancet Neurol. 2021 Apr 27:S1474-4422(21)00063-6. doi: 10.1016/S1474-4422(21)00063-6. Online ahead of print. PMID: 33930317 Review.
Effect of continuous positive airway pressure treatment of obstructive sleep apnea-hypopnea in multiple sclerosis: A randomized, double-blind, placebo-controlled trial (SAMS-PAP study). Khadadah S, Kimoff RJ, Duquette P, Jobin V, Lapierre Y, Benedetti A, Johara FT, Robinson A, Roger E, Bar-Or A, Leonard G, Kaminska M, Trojan DA. Mult Scler. 2021 Apr 23:13524585211010390. doi: 10.1177/13524585211010390. Online ahead of print. PMID: 33890515
Proteomic Profiling of MIS-C Patients Reveals Heterogeneity Relating to Interferon Gamma Dysregulation and Vascular Endothelial Dysfunction. Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrell A, Lambert MP, Sullivan KE, John Wherry E, Teachey DT, Bassiri H, Behrens EM. medRxiv. 2021 Apr 20:2021.04.13.21255439. doi: 10.1101/2021.04.13.21255439. Preprint.
HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury. Aufhauser DD Jr, Hernandez P, Concors SJ, O'Brien C, Wang Z, Murken DR, Samanta A, Beier UH, Krumeich L, Bhatti TR, Wang Y, Ge G, Wang L, Cheraghlou S, Wagner FF, Holson EB, Kalin JH, Cole PA, Hancock WW, Levine MH. Sci Rep. 2021 Apr 27;11(1):9018. doi: 10.1038/s41598-021-88242-3. PMID: 33907245
Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γsignature. Farias Amorim C, O Novais F, Nguyen BT, Nascimento MT, Lago J, Lago AS, Carvalho LP, Beiting DP, Scott P. PLoS Negl Trop Dis. 2021 Apr 1;15(4):e0009321. doi: 10.1371/journal.pntd.0009321. Online ahead of print. PMID: 33793565
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination. Goel RR, Apostolidis SA, Painter MM, Mathew D, Pattekar A, Kuthuru O, Gouma S, Hicks P, Meng W, Rosenfeld AM, Dysinger S, Lundgreen KA, Kuri-Cervantes L, Adamski S, Hicks A, Korte S, Oldridge DA, Baxter AE, Giles JR, Weirick ME, McAllister CM, Dougherty J, Long S, D'Andrea K, Hamilton JT, Betts MR, Luning Prak ET, Bates P, Hensley SE, Greenplate AR, Wherry EJ. Sci Immunol. 2021 Apr 15;6(58):eabi6950. doi: 10.1126/sciimmunol.abi6950. PMID: 33858945
BCR-Induced Ca²⁺ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells. Berry CT, Liu X, Myles A, Nandi S, Chen YH, Hershberg U, Brodsky IE, Cancro MP, Lengner CJ, May MJ, Freedman BD. Cell Rep. 2020 Apr 14;31(2):107474. doi: 10.1016/j.celrep.2020.03.038. PMID: 32294437
Immune dysregulation in human ITCH deficiency successfully treated with hematopoietic cell transplantation. Patel T, Henrickson SE, Moser EK, Field NS, Maurer K, Dawany N, Conrad M, Bunin N, Freedman JL, Heimall J, Arnold DE, Wang J, Markowitz JE, Payne-Poff SB, Williams KW, Russo PA, Wherry EJ, Devoto M, Oliver P, Sullivan KE, Kelsen JR. J Allergy Clin Immunol Pract. 2021 Apr 21:S2213-2198(21)00450-5. doi: 10.1016/j.jaip.2021.04.010. Online ahead of print. PMID: 33894394
Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Cummins KD, Lee YG, Pajarillo R, Chun I, Shyu A, Highfill SL, Price A, Zhao L, Peng L, Granda B, Ramones M, Lu XM, Christian DA, Perazzelli J, Lacey SF, Roy NH, Burkhardt JK, Colomb F, Damra M, Abdel-Mohsen M, Liu T, Liu D, Standley DM, Young RM, Brogdon JL, Grupp SA, June CH, Maude SL, Gill S, Ruella M. Nat Med. 2021 Apr 22. doi: 10.1038/s41591-021-01326-5. Online ahead of print. PMID: 33888899
Foramen Magnum Dural Arteriovenous Fistula Presenting With Thoracic Myelopathy: Technical Case Report With 2-Dimensional Operative Video. Gadot R, Gopakumar S, Wagner K, Xu DS, Raper DMS, Burkhardt JK, Ropper AE. Oper Neurosurg (Hagerstown). 2021 Apr 7:opab077. doi: 10.1093/ons/opab077. Online ahead of print. PMID: 33825904
Crossing the Carotid Siphon: Techniques to Facilitate Distal Access in Tortuous Anatomy: 2-Dimensional Operative Video. Hadley C, Burkhardt JK, Johnson JN, Kan P; Endovascular Neurosurgery Research Group. Oper Neurosurg (Hagerstown). 2021 Apr 2:opab084. doi: 10.1093/ons/opab084. Online ahead of print. PMID: 33822191
Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation. Li L, Zhang X, Wang X, Kim SW, Herndon JM, Becker-Hapak MK, Carreno BM, Myers NB, Sturmoski MA, McLellan MD, Miller CA, Johanns TM, Tan BR, Dunn GP, Fleming TP, Hansen TH, Goedegebuure SP, Gillanders WE. Genome Med. 2021 Apr 21;13(1):56. doi: 10.1186/s13073-021-00872-4. PMID: 33879241
Empirical Mode Decomposition-Derived Entropy Features Are Beneficial to Distinguish Elderly People with a Falling History on a Force Plate Signal. Chou LW, Chang KM, Wei YC, Lu MK. Entropy (Basel). 2021 Apr 16;23(4):472. doi: 10.3390/e23040472. PMID: 33923557
Disseminated Kaposi sarcoma with cytokine release in an AIDS patient. Chang KM, Hsieh SL, Harris CA. J Microbiol Immunol Infect. 2021 Apr 8:S1684-1182(21)00088-8. doi: 10.1016/j.jmii.2021.03.019. PMID: 33893052 No abstract available.
Mucormycosis after Coronavirus disease 2019 infection in a heart transplant recipient - Case report and review of literature. Khatri A, Chang KM, Berlinrut I, Wallach F. J Mycol Med. 2021 Apr 2;31(2):101125. doi: 10.1016/j.mycmed.2021.101125. PMID: 33857916

March 2021

Impact of Advanced Renal Dysfunction on Posttransplant Outcomes After Living Donor Liver Transplantation in the United States. Bittermann T, Abt PL, Olthoff KM, Kaur N, Heimbach JK, Emamaullee J. Transplantation. 2021 Mar 2. doi: 10.1097/TP.0000000000003728. Online ahead of print. PMID: 33660658
The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation. Benallegue N, Kebir H, Kapoor R, Crockett A, Li C, Cheslow L, Abdel-Hakeem MS, Gesualdi J, Miller MC, Wherry EJ, Church ME, Blanco MA, Alvarez JI. Brain. 2021 Mar 16:awab083. doi: 10.1093/brain/awab083. Online ahead of print. PMID: 33723591
Deep learning segmentation of orbital fat to calibrate conventional MRI for longitudinal studies. Brown RA, Fetco D, Fratila R, Fadda G, Jiang S, Alkhawajah NM, Yeh EA, Banwell B, Bar-Or A, Arnold DL; Canadian Pediatric Demyelinating Disease Network.Neuroimage. 2020 Mar;208:116442. doi: 10.1016/j.neuroimage.2019.116442. Epub 2019 Dec 9. PMID: 31821865
Gene Therapy for Inherited Bleeding Disorders. Arruda VR, Weber J, Samelson-Jones BJ. Semin Thromb Hemost. 2021 Mar;47(2):161-173. doi: 10.1055/s-0041-1722862. Epub 2021 Feb 26. PMID: 33636747
Evolutionary insights into coagulation factor IX Padua and other high-specific-activity variants. Samelson-Jones BJ, Finn JD, Raffini LJ, Merricks EP, Camire RM, Nichols TC, Arruda VR. Blood Adv. 2021 Mar 9;5(5):1324-1332. doi: 10.1182/bloodadvances.2019000405. PMID: 33656538
B cell activating factor modulates the factor VIII immune response in hemophilia A. Doshi BS, Rana J, Castaman G, Shaheen MA, Kaczmarek R, Butterfield JSS, Meeks SL, Leissinger C, Biswas M, Arruda VR. J Clin Invest. 2021 Mar 2:142906. doi: 10.1172/JCI142906. Online ahead of print. PMID: 33651716
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. Vella LA,Giles JR, Baxter AE, Oldridge DA, Diorio C, Kuri-Cervantes L, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen CJ, Conrey PE, Sayed S, Giannini HM, D'Andrea K; UPenn COVID Processing Unit, Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MR, Wherry EJ. Sci Immunol. 2021 Mar 2;6(57):eabf7570. doi: 10.1126/sciimmunol.abf7570. PMID: 33653907
Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis. Si SJ, Tasian SK, Bassiri H, Fisher BT, Atalla J, Patel R, Romberg N, Lambert MP, Paessler M, Behrens EJ, Teachey DT, Sullivan KE. J Clin Immunol. 2021 Mar 24:1-6. doi: 10.1007/s10875-021-01025-3. Online ahead of print. PMID: 33761058
Combined use of emapalumab and ruxolitinib in a patient with refractory hemophagocytic lymphohistiocytosis was safe and effective. Triebwasser MP, Barrett DM, Bassiri H, Bunin N, Elgarten C, Freedman J, Geera AS, Monos D, Lambert MP, Olson T, Seif AE, Paessler M, Petrosa W, Reilly AF, Romberg N, Sullivan KE, Quinn GZ, Behrens E, Teachey DT. Pediatr Blood Cancer. 2021 Mar 22:e29026. doi: 10.1002/pbc.29026. Online ahead of print. PMID: 33754483
Longitudinal Analysis Reveals Distinct Antibody and Memory B Cell Responses in SARS-CoV2 Naïve and Recovered Individuals Following mRNA Vaccination. Goel RR, Apostolidis SA, Painter MM, Mathew D, Pattekar A, Kuthuru O, Gouma S, Kuri-Cervantes L, Meng W, Adamski S, Baxter AE, Giles JR, Weirick ME, McAllister CM, Hicks A, Korte S, Dougherty J, Long S, D'Andrea K, Hamilton JT, Luning Prak ET, Betts MR, Bates P, Hensley SE, Greenplate AR, Wherry EJ. medRxiv. 2021 Mar 6:2021.03.03.21252872. doi: 10.1101/2021.03.03.21252872. Preprint. PMID: 33688691
Effects of sheared chromatin length on ChIP-seq quality and sensitivity. Keller CA, Wixom AQ, Heuston EF, Giardine B, Hsiung CC, Long MR, Miller A, Anderson SM, Cockburn A, Blobel GA, Bodine DM, Hardison RC. G3 (Bethesda). 2021 Mar 31:jkab101. doi: 10.1093/g3journal/jkab101. Online ahead of print. PMID: 33788948
Jack-of-all-trades: itaconate tolerizes NLRP3 inflammasome activation. Fischer NL, Shin S, Brodsky IE. Cell Rep. 2021 Mar 9;34(10):108855. doi: 10.1016/j.celrep.2021.108855. PMID: 33691120
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Dynamics Tracking. Chen H, Li Z, Feng S, Wang A, Richard-Greenblatt M, Hutson E, Andrianus S, Glaser LJ, Rodino KG, Qian J, Jayaraman D, Collman RG, Glascock A, Bushman FD, Lee JS, Cherry S, Fausto A, Weiss SR, Koo H, Corby PM, O'Doherty U, Garfall AL, Vogl DT, Stadtmauer EA, Wang P. medRxiv. 2021 Mar 26:2021.03.17.21253847. doi: 10.1101/2021.03.17.21253847. Preprint. PMID: 33791710
Detection of Microbial Agents in Oropharyngeal and Nasopharyngeal Samples of SARS-CoV-2 Patients. Seckar T, Lin X, Bose D, Wei Z, Rohrbaugh J, Collman RG, Robertson ES. Front Microbiol. 2021 Mar 9;12:637202. doi: 10.3389/fmicb.2021.637202. eCollection 2021. PMID: 33790878
Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function. Weiss SL, Bittinger K, Lee JJ, Friedman ES, Mattei LM, Graham K, Zhang D, Bush J, Balamuth F, McGowan FX Jr, Bushman FD, Baldassano RN, Wu GD, Wallace DC, Collman RG. Crit Care Explor. 2021 Mar 17;3(3):e0360. doi: 10.1097/CCE.0000000000000360. eCollection 2021 Mar. PMID: 33786436
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses. Russell RM, Bibollet-Ruche F, Liu W, Sherrill-Mix S, Li Y, Connell J, Loy DE, Trimboli S, Smith AG, Avitto AN, Gondim MVP, Plenderleith LJ, Wetzel KS, Collman RG, Ayouba A, Esteban A, Peeters M, Kohler WJ, Miller RA, François-Souquiere S, Switzer WM, Hirsch VM, Marx PA, Piel AK, Stewart FA, Georgiev AV, Sommer V, Bertolani P, Hart JA, Hart TB, Shaw GM, Sharp PM, Hahn BH. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2025914118. doi: 10.1073/pnas.2025914118. PMID: 33771926
Dynamic Changes in the Nasal Microbiome Associated with Disease Activity in Patients with Granulomatosis with Polyangiitis. Rhee RL, Lu J, Bittinger K, Lee JJ, Mattei LM, Sreih AG, Chou S, Miner JJ, Cohen NA, Kelly BJ, Lee H, Grayson PC, Collman RG, Merkel PA. Arthritis Rheumatol. 2021 Mar 7. doi: 10.1002/art.41723. Online ahead of print. PMID: 33682371
Green giant-a tiny chloroplast genome with mighty power to produce high-value proteins: history and phylogeny. Daniell H, Jin S, Zhu XG, Gitzendanner MA, Soltis DE, Soltis PS. Plant Biotechnol J. 2021 Mar;19(3):430-447. doi: 10.1111/pbi.13556. Epub 2021 Feb 22. PMID: 33484606
Longitudinal Changes in Prorenin and Renin in the Chronic Renal Insufficiency Cohort. Cho ME, Sweeney C, Fino N, Greene T, Ramkumar N, Huang Y, Ricardo AC, Shafi T, Deo R, Anderson A, Mills KT, Cheung AK; CRIC Study Investigators. Am J Nephrol. 2021 Mar 18:1-11. doi: 10.1159/000514302. Online ahead of print. PMID: 33735863
COVID-19 vaccine response in pregnant and lactating women: a cohort study. Gray KJ, Bordt EA, Atyeo C, Deriso E, Akinwunmi B, Young N, Medina Baez A, Shook LL, Cvrk D, James K, De Guzman R, Brigida S, Diouf K, Goldfarb I, Bebell LM, Yonker LM, Fasano A, Rabi SA, Elovitz MA, Alter G, Edlow AG. Am J Obstet Gynecol. 2021 Mar 24:S0002-9378(21)00187-3. doi: 10.1016/j.ajog.2021.03.023. Online ahead of print. PMID: 33775692
Maternal gut microbiota reflecting poor diet quality is associated with spontaneous preterm birth in a prospective cohort study. Gershuni V, Li Y, Elovitz M, Li H, Wu GD, Compher CW. Am J Clin Nutr. 2021 Mar 11;113(3):602-611. doi: 10.1093/ajcn/nqaa361. PMID: 33515003
Emerging role of 18F-FDG PET/CT in Castleman disease: a review. Koa B, Borja AJ, Aly M, Padmanabhan S, Tran J, Zhang V, Rojulpote C, Pierson SK, Tamakloe MA, Khor JS, Werner TJ, Fajgenbaum DC, Alavi A, Revheim ME. Insights Imaging. 2021 Mar 11;12(1):35. doi: 10.1186/s13244-021-00963-1. PMID: 33709329
Development of quality indicators for the diagnosis and management of achalasia. Kamal AN, Kathpalia P, Otaki F, Bredenoord AJ, Castell DO, Clarke JO, Falk GW, Fass R, Prakash Gyawali C, Kahrilas PJ, Katz PO, Katzka DA, Pandolfino JE, Penagini R, Richter JE, Roman S, Savarino E, Triadafilopoulos G, Vaezi MF, Vela MF, Leiman DA. Neurogastroenterol Motil. 2021 Mar 15:e14118. doi: 10.1111/nmo.14118. Online ahead of print. PMID: 33720448
Age of diagnosis in familial Barrett's associated neoplasia. Glamour BK, Alaber O, Cioffi G, Chandar AK, Barnholtz-Sloan J, Brock W, Falk GW, Canto MI, Wang JS, Iyer PG, Shaheen NJ, Grady WM, Abrams JA, Thota PN, Chak A, Blum AE. Fam Cancer. 2021 Mar 11. doi: 10.1007/s10689-021-00239-z. Online ahead of print. PMID: 33694069
Clinical Research after COVID-19: Embracing a New Normal. Gelfand JM, Hefele BE. J Invest Dermatol. 2021 Mar;141(3):481-483. doi: 10.1016/j.jid.2020.08.004. Epub 2020 Sep 2. PMID: 32890628
Remote intervention engagement and outcomes in the Clinical Trials in Organ Transplantation in Children consortium multisite trial. Duncan-Park S, Dunphy C, Becker J, D'Urso C, Annunziato R, Blatter J, Conrad C, Goldfarb SB, Hayes D Jr, Melicoff-Portillo E, Schecter M, Visner G, Armstrong B, Chin H, Kesler K, Williams NM, Odim JN, Sweet SC, Danziger-Isakov L, Shemesh E. Am J Transplant. 2021 Mar 22. doi: 10.1111/ajt.16567. Online ahead of print. PMID: 33752251
Epithelial cell transforming 2 is regulated by Yes-associated protein 1 and mediates pancreatic cancer progression and metastasis. Li C, Peng Z, Wang Y, Lam G, Nissen N, Tang J, Yuan X, Lewis M, Greene MI, Pandol SJ, Wang Q. Am J Physiol Gastrointest Liver Physiol. 2021 Mar 1;320(3):G380-G395. doi: 10.1152/ajpgi.00185.2020. Epub 2021 Jan 27. PMID: 33501895
Bacteria induce skin regeneration via IL-1β signaling. Wang G, Sweren E, Liu H, Wier E, Alphonse MP, Chen R, Islam N, Li A, Xue Y, Chen J, Chen Y, Lee S, Wang Y, Wang S, Archer NK, Andrews W, Kane MA, Dare E, Reddy SK, Hu Z, Grice EA, Miller LS, Garza LA. Cell Host Microbe. 2021 Mar 26:S1931-3128(21)00131-1. doi: 10.1016/j.chom.2021.03.003. Online ahead of print. PMID: 33798492
Glycolysis is integral to histamine-induced endothelial hyperpermeability. Ziogas A, Sajib MS, Lim JH, Alves TC, Das A, Witt A, Hagag E, Androulaki N, Grossklaus S, Gerlach M, Noll T, Grinenko T, Mirtschink P, Hajishengallis G, Chavakis T, Mikelis CM, Sprott D. FASEB J. 2021 Mar;35(3):e21425. doi: 10.1096/fj.202001634R. PMID: 33566443
Polymicrobial communities in periodontal disease: Their quasi-organismal nature and dialogue with the host. Hajishengallis G, Lamont RJ. Periodontol 2000. 2021 Mar 10. doi: 10.1111/prd.12371. Online ahead of print. PMID: 33690950 Review.
Phagocytosis of Apoptotic Cells in Resolution of Inflammation. Kourtzelis I, Hajishengallis G, Chavakis T. Front Immunol. 2020 Mar 31;11:553. doi: 10.3389/fimmu.2020.00553. eCollection 2020. PMID: 32296442
Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality. Dang MT, Gonzalez MV, Gaonkar KS, Rathi KS, Young P, Arif S, Zhai L, Alam Z, Devalaraja S, To TKJ, Folkert IW, Raman P, Rokita JL, Martinez D, Taroni JN, Shapiro JA, Greene CS, Savonen C, Mafra F, Hakonarson H, Curran T, Haldar M. Cell Rep. 2021 Mar 30;34(13):108917. doi: 10.1016/j.celrep.2021.108917. PMID: 33789113
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1. Zhang Y, Varela L, Szigeti-Buck K, Williams A, Stoiljkovic M, Šestan-Peša M, Henao-Mejia J, D'Acunzo P, Levy E, Flavell RA, Horvath TL, Kaczmarek LK. Nat Commun. 2021 Mar 19;12(1):1731. doi: 10.1038/s41467-021-22003-8. PMID: 33741962
SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2. Kiseleva AA, Troisi EM, Hensley SE, Kohli RM, Epstein JA. J Biochem. 2021 Mar 27:mvab041. doi: 10.1093/jb/mvab041. Online ahead of print. PMID: 33774672
Production of Human CRISPR-Engineered CAR-T Cells. Agarwal S, Wellhausen N, Levine BL, June CH. J Vis Exp. 2021 Mar 15;(169). doi: 10.3791/62299. PMID: 33779622
CAR T cells targeting CD13 controllably induce eradication of acute myeloid leukemia with a single domain antibody switch. He X, Feng Z, Ma J, Zhang X, Ling S, Cao Y, Xing B, Wu Y, Wang L, Katona BW, June CH, Hua X. Leukemia. 2021 Mar 12. doi: 10.1038/s41375-021-01208-2. Online ahead of print. PMID: 33712688
External Validation of the VOCAL-Penn Cirrhosis Surgical Risk Score in Two Large, Independent Health Systems. Mahmud N, Fricker Z, Panchal S, Lewis JD, Goldberg DS, Kaplan DE. Liver Transpl. 2021 Mar 31. doi: 10.1002/lt.26060. Online ahead of print. PMID: 33788365
SACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation. Kaplan DE, Mehta R, Garcia-Tsao G, Albrecht J, Aytaman A, Baffy G, Bajaj J, Hernaez R, Hunt K, Ioannou G, Johnson K, Kanwal F, Lee TH, Monto A, Pandya P, Schaubel D, Taddei TH. Contemp Clin Trials. 2021 Mar 24;104:106367. doi: 10.1016/j.cct.2021.106367. Online ahead of print. PMID: 33771685
Race Adjustment in eGFR Equations Does Not Improve Estimation of Acute Kidney Injury Events in Patients with Cirrhosis. Mahmud N, Asrani SK, Reese PP, Kaplan DE, Taddei TH, Nadim MK, Serper M. Dig Dis Sci. 2021 Mar 24. doi: 10.1007/s10620-021-06943-1. Online ahead of print. PMID: 33761091
Notch signaling at the crossroads of innate and adaptive immunity. Vanderbeck A, Maillard I. J Leukoc Biol. 2021 Mar;109(3):535-548. doi: 10.1002/JLB.1RI0520-138R. Epub 2020 Jun 18. PMID: 32557824 Review.
IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity. Garcia de Mattos Barbosa M, Liu H, Huynh D, Shelley G, Keller ET, Emmer BT, Sherman EJ, Ginsburg D, Kennedy AA, Tai AW, Wobus CE, Mirabelli C, Lanigan TM, Samaniego M, Meng W, Rosenfeld AM, Luning Prak ET, Platt JL, Cascalho M. JCI Insight. 2021 Mar 26:147386. doi: 10.1172/jci.insight.147386. Online ahead of print. PMID: 33769311
Pulmonary Involvement in Primary Systemic Vasculitides. Makhzoum JP, Grayson PC, Ponte C, Robson J, Suppiah R, Watts RA, Luqmani R, Merkel PA, Pagnoux C; DCVAS collaborators. Rheumatology (Oxford). 2021 Mar 31:keab325. doi: 10.1093/rheumatology/keab325. Online ahead of print. PMID: 33788906
Dynamic Changes in the Nasal Microbiome Associated with Disease Activity in Patients with Granulomatosis with Polyangiitis. Rhee RL, Lu J, Bittinger K, Lee JJ, Mattei LM, Sreih AG, Chou S, Miner JJ, Cohen NA, Kelly BJ, Lee H, Grayson PC, Collman RG, Merkel PA. Arthritis Rheumatol. 2021 Mar 7. doi: 10.1002/art.41723. Online ahead of print. PMID: 33682371
Hypertension in Children and Adolescents with Turner Syndrome (TS), Neurofibromatosis 1 (NF1), and Williams Syndrome (WS). Sivasubramanian R, Meyers KE. Curr Hypertens Rep. 2021 Mar 29;23(4):18. doi: 10.1007/s11906-021-01136-7. PMID: 33779870 Review.
Association of Obesity with Cardiovascular Risk Factors and Kidney Disease Outcomes in Primary Proteinuric Glomerulopathies. Shah PP, Brady TM, Meyers KEC, O'Shaughnessy MM, Gibson KL, Srivastava T, Zee J, Cattran D, Tuttle KR, Gadegbeku C, Glenn D, Derebail V, Smith A, Wang CS, Gillespie BW, Bitzer M, Sethna CB. Nephron. 2021 Mar 5:1-11. doi: 10.1159/000513869. Online ahead of print. PMID: 33677435
Updated international expert recommendations for the management of autoimmune bullous diseases during the COVID-19 pandemic. Kasperkiewicz M, Schmidt E, Amagai M, Fairley JA, Joly P, Murrell DF, Payne AS, Yale ML, Zillikens D, Woodley DT. J Eur Acad Dermatol Venereol. 2021 Mar 2:10.1111/jdv.17207. doi: 10.1111/jdv.17207. Online ahead of print. PMID: 33655539
Survival time of juvenile dogs with oral squamous cell carcinoma treated with surgery alone: A Veterinary Society of Surgical Oncology retrospective study. Sharma S, Boston SE, Skinner OT, Perry JA, Verstraete FJM, Lee DB, Van Stee LLL, Thompson C, Boylan M, McKee T, Bergman PJ. Vet Surg. 2021 Mar 27. doi: 10.1111/vsu.13625. Online ahead of print. PMID: 33772819
Personalized cancer vaccine strategy elicits polyfunctional T cells and demonstrates clinical benefits in ovarian cancer. Tanyi JL, Chiang CL, Chiffelle J, Thierry AC, Baumgartener P, Huber F, Goepfert C, Tarussio D, Tissot S, Torigian DA, Nisenbaum HL, Stevenson BJ, Guiren HF, Ahmed R, Huguenin-Bergenat AL, Zsiros E, Bassani-Sternberg M, Mick R, Powell DJ Jr, Coukos G, Harari A, Kandalaft LE. NPJ Vaccines. 2021 Mar 15;6(1):36. doi: 10.1038/s41541-021-00297-5. PMID: 33723260
Laboratory, Clinical, and Survival Outcomes Associated With Peptide Receptor Radionuclide Therapy in Patients With Gastroenteropancreatic Neuroendocrine Tumors. Kipnis ST, Hung M, Kumar S, Heckert JM, Lee H, Bennett B, Soulen MC, Pryma DA, Mankoff DA, Metz DC, Eads JR, Katona BW. JAMA Netw Open. 2021 Mar 1;4(3):e212274. doi: 10.1001/jamanetworkopen.2021.2274. PMID: 33755166
High-specific-activity ¹³¹I-MIBG vs ¹⁷⁷Lu-DOTATATE targeted radionuclide therapy for metastatic pheochromocytoma and paraganglioma. Jha A, Taieb D, Carrasquillo JA, Pryma DA, Patel M, Millo C, de Herder WW, Del Rivero J, Crona J, Shulkin BL, Virgolini I, Chen AP, Mittal BR, Basu S, Dillon JS, Hope TA, Mari Aparici C, Iagaru A, Hicks RJ, Avram AM, Strosberg JR, Civelek AC, Lin FI, Pandit-Taskar N, Pacak K. Clin Cancer Res. 2021 Mar 8:clincanres.3703.2020. doi: 10.1158/1078-0432.CCR-20-3703. Online ahead of print. PMID: 33685867
Disrupting upstream translation in mRNAs is associated with human disease. Lee DSM, Park J, Kromer A, Baras A, Rader DJ, Ritchie MD, Ghanem LR, Barash Y. Nat Commun. 2021 Mar 9;12(1):1515. doi: 10.1038/s41467-021-21812-1. PMID: 33750777
Genome-first approach to rare EYA4 variants and cardio-auditory phenotypes in adults. Ahmadmehrabi S, Li B, Park J, Devkota B, Vujkovic M, Ko YA, Van Wagoner D, Tang WHW, Krantz I, Ritchie M; Regeneron Genetics Center, Brant J, Ruckenstein MJ, Epstein DJ, Rader DJ. Hum Genet. 2021 Mar 21. doi: 10.1007/s00439-021-02263-6. Online ahead of print. PMID: 33745059
Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection. Parzych EM, Gulati S, Zheng B, Bah MA, Elliott STC, Chu JD, Nowak N, Reed GW, Beurskens FJ, Schuurman J, Rice PA, Weiner DB, Ram S. mBio. 2021 Mar 16;12(2):e00242-21. doi: 10.1128/mBio.00242-21. PMID: 33727348
Activation of STING signaling pathway effectively blocks human coronavirus infection. Liu W, Reyes HM, Yang JF, Li Y, Stewart KM, Basil MC, Lin SM, Katzen J, Morrisey EE, Weiss SR, You J. J Virol. 2021 Mar 31:JVI.00490-21. doi: 10.1128/JVI.00490-21. Online ahead of print. PMID: 33789998
Highly multiplexed mass cytometry identifies the immunophenotype in the skin of Dermatomyositis. Patel J, Maddukuri S, Li Y, Bax C, Werth VP. J Invest Dermatol. 2021 Mar 22:S0022-202X(21)01014-9. doi: 10.1016/j.jid.2021.02.748. Online ahead of print. PMID: 33766508
Collaboration for the Management of Hydroxychloroquine. Rosenbaum JT, Costenbader KH, Desmarais J, Ginzler EM, Fett N, Goodman SM, O'Dell JR, Schmajuk G, Werth VP, Melles RB, Marmor MF. Ophthalmology. 2021 Mar 19:S0161-6420(21)00127-5. doi: 10.1016/j.ophtha.2021.02.015. Online ahead of print. PMID: 33752915
Managing interventional clinical trials in the setting of COVID-19: Experience in an autoimmune skin disease unit. Borucki R, Concha JSS, Burroughs J, Okawa J, Werth VP. JAAD Int. 2021 Mar;2:94-95. doi: 10.1016/j.jdin.2020.11.002. Epub 2020 Dec 9. PMID: 33733244
Guidelines for the use of prophylactic agents in pemphigus patients treated with rituximab depend on the individual patient's risk factors. Murrell DF, Joly P, Werth VP. J Am Acad Dermatol. 2021 Mar 10:S0190-9622(21)00510-7. doi: 10.1016/j.jaad.2021.03.018. Online ahead of print. PMID: 33713786
In vivo CD8⁺ T cell CRISPR screening reveals control by Fli1 in infection and cancer. Chen Z, Arai E, Khan O, Zhang Z, Ngiow SF, He Y, Huang H, Manne S, Cao Z, Baxter AE, Cai Z, Freilich E, Ali MA, Giles JR, Wu JE, Greenplate AR, Hakeem MA, Chen Q, Kurachi M, Nzingha K, Ekshyyan V, Mathew D, Wen Z, Speck NA, Battle A, Berger SL, Wherry EJ, Shi J. Cell. 2021 Mar 4;184(5):1262-1280.e22. doi: 10.1016/j.cell.2021.02.019. Epub 2021 Feb 25. PMID: 33636129
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells. Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Nat Immunol. 2021 Mar;22(3):370-380. doi: 10.1038/s41590-021-00868-7. Epub 2021 Feb 11. PMID: 33574619
Memory T-Cell Heterogeneity and Terminology. Muroyama Y, Wherry EJ. Cold Spring Harb Perspect Biol. 2021 Mar 29:a037929. doi: 10.1101/cshperspect.a037929. Online ahead of print. PMID: 33782027
Loss of IL-10 signaling promotes IL-22 dependent host defenses against acute Clostridioides difficile infection. Cribas ES, Denny JE, Maslanka JR, Abt MC.Infect Immun. 2021 Mar 1:IAI.00730-20. doi: 10.1128/IAI.00730-20. Online ahead of print. PMID: 33649048 PMCID: PMC8091099
Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺T cells. Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Nat Immunol. 2021 Mar 3. doi: 10.1038/s41590-021-00906-4. Online ahead of print. PMID: 33658708

February 2021

Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia. Levine L, Arany Z, Kern-Goldberger A, Koelper N, Lewey J, Sammel MD, Elovitz MA, Ky B. Hypertens Pregnancy 2021 Feb;40(1):44-49. PMID: 33345653 PMCID: PMC7856576
Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply is Limited. Ribas A, Sengupta R, Locke T, Zaidi SK, Campbell KM, Carethers JM, Jaffee EM, Wherry EJ, Soria JC, D'Souza G. Cancer Discovery 2021 Feb;11(2):233-236 PMID: 33355178
Cutaneous Findings in SARS-CoV-2-Associated Multisystem Inflammatory Disease in Children. Blatz AM, Oboite M, Chiotos K, Castelo-Soccio L, Odom John AR; Children’s Hospital of Philadelphia MIS-C Research Collaborative. Open Forum Infect Dis. 2021 Feb 16;8(3):ofab074. doi: 10.1093/ofid/ofab074. eCollection 2021 Mar. PMID: 33778091

January 2021

The vascular landscape of human cancer. Kahn BM, Lucas A, Alur R, Wengyn MD, Schwartz GW, Li J, Sun K, Maurer HC, Olive KP, Faryabi RB, Stanger B. J Clin Invest. 2021 Jan 19;131(2):e136655. PMID: 33258803 PMCID: PMC7810485.
ICTV Virus Taxonomy Profile: Redondoviridae. Abbas A, Taylor LJ, Collman RG, Bushman FD, Ictv Report Consortium. J Gen Virol. 2021 Jan;102(1). PMID: 33258767
CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study. O'Hara MH, O'Reilly EM, Varadhachary G, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Mick R, Gherardini PF, Kitch LJ, Xu J, Samuel T, Karakunnel J, Fairchild J, Bucktrout S, LaVallee TM, Selinsky C, Till JE, Carpenter EL, Alanio C, Byrne KT, Chen RO, Trifan OC, Dugan U, Horak C, Hubbard-Lucey VM, Wherry EJ, Ibrahim R, Vonderheide RH. Lancet Oncology 2021 Jan;22(1):118-131. PMID: 33387490

2020

December 2020

Global brain glucose uptake on 18F-FDG-PET/CT is influenced by chronic cardiovascular risk. Borja AJ, Hancin EC, Zhang V, Koa B, Bhattaru A, Rojulpote C, Detchou DK, Aly M, Kaghazchi F, Gerke O, Patil S, Gonuguntla K, Werner TJ, Revheim ME, Høilund-Carlsen PF, Alavi A. Nucl Med Commun. 2020 Dec 14. doi: 10.1097/MNM.0000000000001349. Online ahead of print. PMID: 33323870
Rubella virus-associated chronic inflammation in primary immunodeficiency diseases. Perelygina L, Icenogle J, Sullivan KE. Curr Opin Allergy Clin Immunol. 2020 Dec;20(6):574-581. PMID: 33044342 PMCID: PMC7730704
Magnetic resonance imaging-based partial volume-corrected 18F-sodium fluoride positron emission tomography in the femoral neck. Ayubcha C, Raynor WY, Borja AJ, Seraj SM, Rojulpote C, Werner TJ, Revheim ME, Rajapakse CS, Alavi A. Nucl Med Commun. 2020 Dec 9. doi: 10.1097/MNM.0000000000001344. Online ahead of print. PMID: 33306627
Derivation and investigation of the first human cell-based model of Beckwith-Wiedemann syndrome. Chang S, Hur SK, Naveh NSS, Thorvaldsen JL, French DL, Gagne AL, Jobaliya CD, Anguera MC, Bartolomei MS, Kalish JM. Epigenetics. 2020 Dec 10. doi: 10.1080/15592294.2020.1861172. Online ahead of print.PMID: 33300436
The Identity of Human Tissue-Emigrant CD8⁺ T Cells. Buggert M, Vella LA, Nguyen S, Wu VH, Chen Z, Sekine T, Perez-Potti A, Maldini CR, Manne S, Darko S, Ransier A, Kuri-Cervantes L, Japp AS, Brody IB, Ivarsson MA, Gorin JB, Rivera-Ballesteros O, Hertwig L, Antel JP, Johnson ME, Okoye A, Picker L, Vahedi G, Sparrelid E, Llewellyn-Lacey S, Gostick E, Sandberg JK, Björkström N, Bar-Or A, Dori Y, Naji A, Canaday DH, Laufer TM, Wells AD, Price DA, Frank I, Douek DC, Wherry EJ, Itkin MG, Betts MR. Cell. 2020 Dec 4:S0092-8674(20)31536-1. doi: 10.1016/j.cell.2020.11.019. Online ahead of print.PMID: 33306960
Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT. Blood Adv. 2020 Dec 8;4(23):6051-6063. doi: 10.1182/bloodadvances.2020003471.PMID: 33290544
American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID-19. Version 2. Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Ferris A, Kernan KF, Schulert GS, Seo P, Son MBF, Tremoulet AH, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta JJ. Arthritis Rheumatol. 2020 Dec 5. doi: 10.1002/art.41616. Online ahead of print.PMID: 33277976
SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19. Anderson EM, Diorio C, Goodwin EC, McNerney KO, Weirick ME, Gouma S, Bolton MJ, Arevalo CP, Chase J, Hicks P, Manzoni TB, Baxter AE, Andrea KP, Burudpakdee C, Lee JH, Vella LA, Henrickson SE, Harris RM, Wherry EJ, Bates P, Bassiri H, Behrens EM, Teachey DT, Hensley SE. J Pediatric Infect Dis Soc. 2020 Dec 2:piaa161. doi: 10.1093/jpids/piaa161. Online ahead of print.PMID: 33263756
A Pilot Study of Galunisertib Plus Stereotactic Body Radiotherapy in Patients with Advanced Hepatocellular Carcinoma. Reiss KA, Wattenberg MM, Damjanov N, Prechtel Dunphy E, Jacobs-Small M, Lubas MJ, Robinson J, Dicicco L, Garcia-Marcano L, Giannone MA, Karasic TB, Furth EE, Carpenter EL, Wojcieszynski AP, Vonderheide RH, Beatty GL, Ben-Josef E. Mol Cancer Ther. 2020 Dec 2:molcanther.0632.2020. doi: 10.1158/1535-7163.MCT-20-0632. Online ahead of print.PMID: 33268571

November 2020

Is it safe to eat in a restaurant if you have peanut allergy? Jonathan Spergel. Ann Allergy Astma Immunol. 2020 Nov; 125(5):499-500. PMID:33097165
Pathogenesis of heparin - induced thrombocytopenia. Gowthami Arepally, Douglas Cines. Transl Res. 2020 Nov;225:131-140. PMID: 32417430 PMCID: PMC7487042
From conception to COVID-19: an arduous journey of tribulations of racism and triumphs. Henry Daniell. Plant Biotechnol J. 2020 Nov;18(11):2147-2154. PMID: 32799416 PMCID: PMC7460971

October 2020

Anti-drug antibodies to TNF inhibitors in hidradenitis suppurativa: a systematic review. Lu JD, Milakovic M, Piguet V, Alavi A. Br J Dermatol. 2020 Oct 2. doi: 10.1111/bjd.19591. Online ahead of print. PMID: 33006769
Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers. Dorsey MJ, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, Chandra S, Chaudhury S, Chen K, Chong H, Cuvelier GDE, Dalal J, DeFelice ML, DeSantes KB, Forbes LR, Gillio A, Goldman F, Joshi AY, Kapoor N, Knutsen AP, Kobrynski L, Lieberman JA, Leiding JW, Oshrine B, Patel KP, Prockop S, Quigg TC, Quinones R, Schultz KR, Seroogy C, Shyr D, Siegel S, Smith AR, Torgerson TR, Vander Lugt MT, Yu LC, Cowan MJ, Buckley RH, Dvorak CC, Griffith LM, Haddad E, Kohn DB, Logan B, Notarangelo LD, Pai SY, Puck J, Pulsipher MA, Heimall J. J Clin Immunol. 2020 Oct 2. doi: 10.1007/s10875-020-00865-9. Online ahead of print.
PMID: 33006109
STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Paris AJ, Hayer KE, Oved JH, Avgousti DC, Toulmin SA, Zepp JA, Zacharias WJ, Katzen JB, Basil MC, Kremp MM, Slamowitz AR, Jayachandran S, Sivakumar A, Dai N, Wang P, Frank DB, Eisenlohr LC, Cantu E 3rd, Beers MF, Weitzman MD, Morrisey EE, Worthen GS. Nat Cell Biol. 2020 Oct;22(10):1197-1210. doi: 10.1038/s41556-020-0569-x. Epub 2020 Sep 28. PMID: 32989251
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies. Parker KR, Migliorini D, Perkey E, Yost KE, Bhaduri A, Bagga P, Haris M, Wilson NE, Liu F, Gabunia K, Scholler J, Montine TJ, Bhoj VG, Reddy R, Mohan S, Maillard I, Kriegstein AR, June CH, Chang HY, Posey AD Jr, Satpathy AT. Cell. 2020 Oct 1;183(1):126-142.e17. doi: 10.1016/j.cell.2020.08.022. Epub 2020 Sep 21. PMID: 32961131
Echocardiographic strain analysis reflects impaired ventricular function in youth with pediatric-onset systemic lupus erythematosus. Chang JC, Wang Y, Xiao R, Fedec A, Meyers KE, Tinker C, Natarajan SS, Knight AM, Weiss PF, Mercer-Rosa L. Echocardiography. 2020 Oct 3. doi: 10.1111/echo.14872. Online ahead of print. PMID: 33009676
Implications of Tattoos That Oral Healthcare Providers Should Consider. Bindakhil MA, Sollecito TP, Stoopler ET. Compend Contin Educ Dent.2020 Oct;41(9):e10-e11. PMID: 33001662
Erratum to: Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to mifraine headache. Siewert KM, Klarin D, Damrauer SM, Chang KM, Tsao PS, Assimes TL, Smith GD, Voight BF. Int J Epidemiol 2020 Oct 1;49(5):1759. PMID: 33280006 PMCID: PMC7746405.

September 2020

Pyoderma gangrenosum: proposed pathogenesis and current use of biologics with an emphasis on complement C5a inhibitor IFX-1. Lu JD, Milakovic M, Ortega-Loayza AG, Marzano AV, Alavi A. Expert Opin Investig Drugs. 2020 Sep 3. Online ahead of print. PMID: 32880206
Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome. Diorio C, Anderson EM, McNerney KO, Goodwin EC, Chase JC, Bolton MJ, Arevalo CP, Weirick ME, Gouma S, Vella LA, Henrickson SE, Chiotos K, Fitzgerald JC, Kilbaugh TJ, John ARO, Blatz AM, Lambert MP, Sullivan KE, Tartaglione MR, Zambrano D, Martin M, Lee JH, Young P, Friedman D, Sesok-Pizzini DA, Hensley SE, Behrens EM, Bassiri H, Teachey DT. Pediatr Blood Cancer. 2020 Sep 4:e28693. Online ahead of print. PMID: 32885904
Dural substitutes differentially interfere with imaging quality of sonolucent trans-cranioplasty ultrasound assessment in benchtop model. Flores A, Srinivasan VM, Gadot R, Kan P, Burkhardt JK. World Neurosurg. 2020 Sep 2:S1878-8750(20)31935-5. PMID: 32890844
Local complement activation is associated with primary graft dysfunction after lung transplantation. Kulkarni HS, Ramphal K, Ma L, Brown M, Oyster M, Speckhart KN, Takahashi T, Byers DE, Porteous MK, Kalman L, Hachem RR, Rushefski M, McPhatter J, Cano M, Kreisel D, Scavuzzo M, Mittler B, Cantu E 3rd, Pilely K, Garred P, Christie JD, Atkinson JP, Gelman AE, Diamond JM. JCI Insight. 2020 Sep 3;5(17):138358. PMID: 32750037
Validation of the Waterless Empirical Taste Test (WETT ®) Doty RL, Wylie C, Potter M. Behav Res Methods. 2020 Sep 3. PMID: 32885386
Chemosensory Dysfunction in COVID-19: Prevalences, Recovery Rates, and Clinical Associations on a Large Brazilian Sample. Brandão Neto D, Fornazieri MA, Dib C, Di Francesco RC, Doty RL, Voegels RL, Pinna FR. Otolaryngol Head Neck Surg. 2020 Sep 1:194599820954825. PMID: 32867582
Clinical research post COVID-19: Embracing a new normal. Gelfand JM, Hefele BE. J Invest Dermatol. 2020 Sep 2:S0022-202X(20)31979-5. PMID: 32890628 PMCID: PMC7466954
Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms. Singh BK, Lu W, Schmidt Paustian AM, Ge MQ, Koziol-White CJ, Flayer CH, Killingbeck SS, Wang N, Dong X, Riese MJ, Deshpande DA, Panettieri RA Jr, Haczku A, Kambayashi T. Sci Signal. 2019 Sep 3;12(597):eaax3332. PMID: 31481522 PMCID: PMC6996596
Hepatitis C Virus. Kaplan DE. Ann Intern Med. 2020 Sep 1;173(5):ITC33-ITC48. PMID: 32866406
Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses. Chen J, Harding SM, Natesan R, Tian L, Benci JL, Li W, Minn AJ, Asangani IA, Greenberg RA. Cell Rep. 2020 Sep 1;32(9):108080. PMID: 32877684
68 Ga-DOTATATE PET/CT quantification predicts response to somatostatin analog therapy in gastroenteropancreatic neuroendocrine tumors. Lee H, Eads JR, Pryma DA. Oncologist. 2020 Sep 4. PMID: 32886441
Anti-Inflammatory HDL Function, Incident Cardiovascular Events, and Mortality: A Secondary Analysis of the JUPITER Randomized Clinical Trial. Ajala ON, Demler OV, Liu Y, Farukhi Z, Adelman SJ, Collins HL, Ridker PM, Rader DJ, Glynn RJ, Mora S. J Am Heart Assoc. 2020 Sep;9(17):e016507. Aug 15. PMID: 32799709
Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID) in the US Immunodeficiency Network (USIDNet) Registry. Kuo CY, Garabedian E, Puck J, Cowan MJ, Sullivan KE, Buckley RH, Cunningham-Rundles C, Marsh R, Candotti F, Kohn DB. J Clin Immunol.2020 Sep 2. PMID: 32880085
Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala. O'Leary TP, Sullivan KE, Wang L, Clements J, Lemire AL, Cembrowski MS. Elife. 2020 Sep 1;9:e59003. PMID: 32869744
Optimizing Therapy in the Modern Age: Differences in Length of Maintenance Therapy in Acute Lymphoblastic Leukemia. Teachey DT, Hunger SP, Loh ML. Blood. 2020 Sep 2:blood.2020007702. PMID: 32877503
PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma. Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA, Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. JCI Insight. 2020 Sep 3;5(17):133225. PMID: 32780726
Pioneer Transcription Factors Initiating Gene Network Changes. Zaret KS. Annu Rev Genet. 2020 Sep 4. PMID: 32886547

August 2020

Type 1 Conventional Dendritic Cells Are Systemically Dysregulated Early in Pancreatic Carcinogenesis. Lin JH, Huffman AP, Wattenberg MM, Walter DM, Carpenter EL, Feldser DM, Beatty GL, Furth EE, Vonderheide RH. J Exp Med. 2020 Aug 3;217(8). PMID: 32453421 PMCID: PMC7398166
Wide Variation in the Percentage of Donation After Circulatory Death Donors Across Donor Service Areas: A Potential Target for Improvement. Sonnenberg EM, Hsu JY, Reese PP, Goldberg DS, Abt PL. Transplantation. 2020 Aug;104(8):1668-1674. PMID: 32732846
Multiple roles for hepatitis B and C viruses and the host in the development of hepatocellular carcinoma. Wangensteen KJ, Chang KM. Hepatology. 2020 Aug 1. doi: 10.1002/hep.31481. Online ahead of print. PMID: 32737895
Hepatitis C virus modulates IgG glycosylation in HIV co-infected antiretroviral therapy suppressed individuals. Giron LB, Azzoni L, Yin X, Lynn KM, Ross BN, Fair M, Damra M, Sciorillo AC, Liu Q, Jacobson JM, Mounzer K, Kostman JR, Abdel-Mohsen M, Montaner LJ, Papasavvas E. AIDS. 2020 Aug 1;34(10):1461-1466. PMID: 32675559 PMCID: PMC7371238
ACR-ACNM-ASTRO-SNMMI Practice Parameter for the Performance of Therapy With Radium-223. Hurwitz M, Buscombe JR, Jacene HA, Klitzke AK, Lamonica D, Lu Y, Pryma DA, Rohren EM, Speer TW, Subramaniam RM, Thompson HM, Tomblyn MB, Wong WW, Xiao Y, Banks KP, Brown RKJ. Am J Clin Oncol. 2020 Aug;43(8):539-544. PMID: 32520788
Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [68Ga]Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies. Doot RK, Young AJ, Daube-Witherspoon ME, Alexoff D, Labban KJ, Lee H, Wu Z, Zha Z, Choi SR, Ploessl KH, Schubert EK, Lee H, Zhu L, Reddin JS, Karp JS, Kung H, Pryma DA. Nucl Med Biol. 2020 Jul-Aug;86-87:1-8. PMID: 32361089 PMCID: PMC7311273
Using scholarly productivity as an outcome assessment of a dental residency program. Stoopler ET, De Rossi SS, Greenberg MS, Sollecito TP. Spec Care Dentist. 2020 Sep 2. PMID: 32880996 No abstract available.
Introduction to dental medicine: Analysis of a massive open online course in dentistry. France K, Hangorsky U, Wu CW, Sollecito TP, Stoopler ET. J Dent Educ. 2020 Sep 2. PMID: 32876333
CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA, Zon LI. Proc Natl Acad Sci U S A. 2020 Sep 3:202003228. PMID: 32883883

July 2020

Evaluating the impact of prior authorizations in patients with complex dermatological conditions. Jew OS, Okawa J, Barbieri JS, McCaffrey J, Hayward E, Werth VP. J Am Acad Dermatol. 2020 Jul 1.
Good news for the treatment of narrow-caliber esophagus ineosinophilic esophagitis. Lynch KL, Falk GW. Gastrointest Endosc. 2020 Jul;92(1):54-55.
Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells. Su C, Johnson ME, Torres A, Thomas RM, Manduchi E, Sharma P, Mehra P, Le Coz C, Leonard ME, Lu S, Hodge KM, Chesi A, Pippin J, Romberg N, Grant SFA, Wells AD. Nat Commun. 2020 Jul 3;11(1):3294
Nucleic Acid Approaches to Antibody-based Therapeutics for COVID-19: A Perspective. Parzych E, Weiner DB. J Allergy Clin Immunol. 2020 Jul 2.
Recommendations for phototherapy during the COVID-19 pandemic. Lim HW, Feldman SR, Van Voorhees AS, Gelfand JM. J Am Acad Dermatol. 2020 Jul;83(1):287-288
Reply to: "Do IL-17 Inhibitors Increase Risk of Respiratory Tract Infections?" Wan MT, Shin DB, Winthrop KL, Gelfand JM. J Am Acad Dermatol. 2020 Jul 1.
The Risk of Respiratory Tract Infections in Psoriasis Patients Treated With IL-23-pathway Inhibiting Biologics: A Meta-Estimate of Pivotal Trials Relevant to Decision-Making During the COVID-19 Pandemic. Syed MN, Shin DB, Wan MT, Winthrop KL, Gelfand JM. J Am Acad Dermatol. 2020 Jul 2.
TOX is expressed by exhausted and polyfunctional human effector memory CD8 ⁺ T cells. Sekine T, Perez-Potti A, Nguyen S, Gorin JB, Wu VH, Gostick E, Llewellyn-Lacey S, Hammer Q, Falck-Jones S, Vangeti S, Yu M, Smed-Sörensen A, Gaballa A, Uhlin M, Sandberg JK, Brander C, Nowak P, Goepfert PA, Price DA, Betts MR, Buggert M. Sci Immunol. 2020 Jul 3;5(49).
Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells. Gao P, Chen C, Howell ED, Li Y, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann AF, Speck NA, Tan K. Genes Dev. 2020 Jul 1;34(13-14):950-964.
Predictors, Presentation, and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience. Ekpanyapong S, Philips N, Loza BL, Abt P, Furth EE, Tondon R, Khungar V, Olthoff K, Shaked A, Hoteit MA, Reddy KR. J Clin Exp Hepatol. 2020 Jul-Aug;10(4):304-315. doi: 10.1016/j.jceh.2019.11.003. Epub 2019 Nov 22. PMID: 32655233 PMCID: PMC7335705