Archived Publications

2021
2020

2021

December 2021

Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children With Sepsis. Weiss SL, Henrickson SE, Lindell RB, Sartori LF, Zhang D, Bush J, Farooqi S, Starr J, Deutschman CS, McGowan FX Jr, Becker L, Tuluc F, Wherry EJ, Picard M, Wallace DC. Shock. 2021 Dec 28. doi: 10.1097/SHK.0000000000001903. Online ahead of print. PMID: 34966070
BLyS neutralization results in selective anti-HLA alloantibody depletion without successful desensitization. Agarwal D, Luning Prak ET, Bharani T, Everly M, Migone TS, Cancro M, Allman D, Choe I, Kearns JD, Trofe-Clark J, Naji A, Kamoun M. Transpl Immunol. 2021 Dec;69:101465. PMID: 34506905
The evolution of the ISHLT transplant registry. Preparing for the future. Stehlik J, Christie JD, Goldstein DR, Amarelli C, Bertolotti A, Chambers DC, Dorent R, Gonzalez-Vilchez F, Parameshwar J, Perch M, Zuckermann A, Coll E, Levy RD, Atik FA, Gomez-Mesa JE, Moayedi Y, Peled-Potashnik Y, Schultz G, Cherikh W, Danziger-Isakov L. J Heart Lung Transplant. 2021 Dec;40(12):1670-1681. PMID: 34657795
Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrel A, Lambert MP, Sullivan KE, Wherry EJ, Teachey DT, Bassiri H, Behrens EM. Nature Comunications. 2021 Dec 10;12(1):7222. PMID: 34893640
Pain killers: the interplay between nonsteroidal anti-inflammatory drugs and Clostridioides difficile infection. Soto Ocaña J, Bayard NU, Zackular JP. Curr Opin Microbiol. 2021 Dec 8;65:167-174. PMID: 34894543
Global Microbiota-Dependent Histone Acetylation Patterns Are Irreversible and Independent of Short Chain Fatty Acids. Saiman Y, Shen TD, Lund PJ, Gershuni VM, Jang C, Patel S, Jung S, Furth EE, Friedman ES, Chau L, Garcia BA, Wu GD. Hepatology. 2021 Dec;74(6):3427-3440. PMID: 34233020
Local tissue heterogeneity may modulate neuronal responses via altered axon strain fields: insights about innervated joint capsules from a computational model. Middendorf JM, Ita ME, Winkelstein BA, H Barocas V. Biomech Model Mechanobiol. 2021 Dec;20(6):2269-2285. PMID: 34514531
American College of Rheumatology White Paper on Antimalarial Cardiac Toxicity. Desmarais J, Rosenbaum JT, Costenbader KH, Ginzler EM, Fett N, Goodman S, O'Dell J, Pineau CA, Schmajuk G, Werth VP, Link MS, Kovacs R. Arthritis Rheumatol. 2021 Dec;73(12):2151-2160. PMID: 34697918

November 2021

Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination. Kahn B, Apostolidis SA, Bhatt V, Greenplate AR, Kallish S, LaCava A, Lucas A, Meyer NJ, Negoianu D, Ogdie AR, Shashaty MGS, Takach PA, Zuroff L, Wherry EJ, Anesi GL. Crit Care Explor. 2021 Nov 5;3(11):e0578. doi: 10.1097/CCE.0000000000000578. PMID: 34765984.
Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Nat Immunol. 2021 Nov;22(11):1465. PMID: 34588688
A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia. Bar KJ, Shaw PA, Choi GH, Aqui N, Fesnak A, Yang JB, Soto-Calderon H, Grajales L, Starr J, Andronov M, Mastellone M, Amonu C, Feret G, DeMarshall M, Buchanan M, Caturla M, Gordon J, Wanicur A, Monroy MA, Mampe F, Lindemuth E, Gouma S, Mullin AM, Barilla H, Pronina A, Irwin L, Thomas R, Eichinger RA, Demuth F, Luning Prak ET, Pascual JL, Short WR, Elovitz MA, Baron J, Meyer NJ, Degnan KO, Frank I, Hensley SE, Siegel DL, Tebas P. J Clin Invest. 2021 Nov 17:e155114. PMID: 34788233
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Apostolidis SA, Kakara M, Painter MM, Goel RR, Mathew D, Lenzi K, Rezk A, Patterson KR, Espinoza DA, Kadri JC, Markowitz DM, E Markowitz C, Mexhitaj I, Jacobs D, Babb A, Betts MR, Prak ETL, Weiskopf D, Grifoni A, Lundgreen KA, Gouma S, Sette A, Bates P, Hensley SE, Greenplate AR, Wherry EJ, Li R, Bar-Or A. Nat Med. 2021 Nov;27(11):1990-2001PMID: 34522051
Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells. Adeniji OS, Kuri-Cervantes L, Yu C, Xu Z, Ho M, Chew GM, Shikuma C, Tomescu C, George AF, Roan NR, Ndhlovu LC, Liu Q, Muthumani K, Weiner DB, Betts MR, Xiao H, Abdel-Mohsen M. PLoS Pathog. 2021 Nov 11;17(11):e1010034. PMID: 34762717
MELD-based allocation at 20: Can we evolve and mature? Bittermann T, Abt PL. Am J Transplant. 2021 Nov;21(11):3511-3512. PMID: 34375509
Diagnosis of bone metastases in breast cancer: Lesion-based sensitivity of dual-time-point FDG-PET/CT compared to low-dose CT and bone scintigraphy. Hansen JA, Naghavi-Behzad M, Gerke O, Baun C, Falch K, Duvnjak S, Alavi A, Høilund-Carlsen PF, Hildebrandt MG. PLoS One. 2021 Nov 18;16(11):e0260066. PMID: 34793550 PMCID: PMC8601566
Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments. McCorkell KA, Jayachandran N, Cully MD, Freund-Brown J, Weinkopff T, Monslow J, Hu Y, Puré E, Freedman BD, Alvarez JI, Cancro MP, May MJ. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2100195118. PMID: 34810256
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Alameh MG, Tombácz I, Bettini E, Lederer K, Sittplangkoon C, Wilmore JR, Gaudette BT, Soliman OY, Pine M, Hicks P, Manzoni TB, Knox JJ, Johnson JL, Laczkó D, Muramatsu H, Davis B, Meng W, Rosenfeld AM, Strohmeier S, Lin PJC, Mui BL, Tam YK, Karikó K, Jacquet A, Krammer F, Bates P, Cancro MP, Weissman D, Luning Prak ET, Allman D, Locci M, Pardi N. Immunity. 2021 Nov 4:S1074-7613(21)00490-8. PMID: 34852217 PMCID: PMC8566475
Clostridioides difficile and the Microbiota Early in Life. Semon AK, Keenan O, Zackular JP. J Pediatric Infect Dis Soc. 2021 Nov 17;10(Supplement_3):S3-S7. PMID: 34791400 PMCID: PMC8600012
Clostridioides difficile Infection in Children: Research Progress, Pitfalls, and Priorities. Kociolek LK, Burnham CD, Nicholson MR, Zackular JP. J Pediatric Infect Dis Soc. 2021 Nov 17;10(Supplement_3):S1-S2. PMID: 34791394
Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations. Kociolek LK, Zackular JP, Savidge T. J Pediatric Infect Dis Soc. 2021 Nov 17;10(Supplement_3):S8-S15. PMID: 34791392 PMCID: PMC8600028
SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens. Bartolo L, Afroz S, Pan YG, Xu R, Williams L, Lin CF, Friedman ES, Gimotty PA, Wu GD, Su LF. bioRxiv. 2021 Nov 30:2021.11.29.470421. PMID: 34873598 PMCID: PMC8647649
Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome. Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD. Gastroenterology. 2021 Nov 10:S0016-5085(21)03728-8. PMID: 34774538
Role of CXCL5 in Regulating Chemotaxis of Innate and Adaptive Leukocytes in Infected Lungs Upon Pulmonary Influenza Infection. Guo L, Li N, Yang Z, Li H, Zheng H, Yang J, Chen Y, Zhao X, Mei J, Shi H, Worthen GS, Liu L. Front Immunol. 2021 Nov 18;12:785457. PMID: 34868067
Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Myerson JW, Patel PN, Rubey KM, Zamora ME, Zaleski MH, Habibi N, Walsh LR, Lee YW, Luther DC, Ferguson LT, Marcos-Contreras OA, Glassman PM, Mazaleuskaya LL, Johnston I, Hood ED, Shuvaeva T, Wu J, Zhang HY, Gregory JV, Kiseleva RY, Nong J, Grosser T, Greineder CF, Mitragotri S, Worthen GS, Rotello VM, Lahann J, Muzykantov VR, Brenner JS. Nat Nanotechnol. 2021 Nov 18. doi: 10.1038/s41565-021-00997-y. PMID: 34795440
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits. Pahl MC, Doege CA, Hodge KM, Littleton SH, Leonard ME, Lu S, Rausch R, Pippin JA, De Rosa MC, Basak A, Bradfield JP, Hammond RK, Boehm K, Berkowitz RI, Lasconi C, Su C, Chesi A, Johnson ME, Wells AD, Voight BF, Leibel RL, Cousminer DL, Grant SFA. Nat Commun. 2021 Nov 19;12(1):6749. PMID: 34799566

October 2021

The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination. Beilinson HA, Glynn RA, Yadavalli AD, Xiao J, Corbett E, Saribasak H, Arya R, Miot C, Bhattacharyya A, Jones JM, Pongubala JMR, Bassing CH, Schatz DG .J Exp Med. 2021 Oct 4;218(10):e20210250. doi: 10.1084/jem.20210250. Epub 2021 Aug 17. PMID: 34402853
Non-invasive imaging for the diagnosis of acute rejection in transplantation: The next frontier. Matar AJ, Crepeau RL, Duran-Struuck R. Transpl Immunol. 2021 Oct;68:101431. doi: 10.1016/j.trim.2021.101431. Epub 2021 Jun 19. PMID: 34157374
A Cre-driven allele-conditioning line to interrogate CD4 + conventional T cells. Andrews LP, Vignali KM, Szymczak-Workman AL, Burton AR, Brunazzi EA, Ngiow SF, Harusato A, Sharpe AH, Wherry EJ, Taniuchi I, Workman CJ, Vignali DAA. Immunity. 2021 Oct 12;54(10):2209-2217.e6. doi: 10.1016/j.immuni.2021.08.029. Epub 2021 Sep 21. PMID: 34551314
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ, Adamski S, Alam Z, Addison MM, Byrne KT, Chandra A, Descamps HC, Han N, Kaminskiy Y, Kammerman SC, Kim J, Greenplate AR, Hamilton JT, Markosyan N, Noll JH, Omran DK, Pattekar A, Perkey E, Prager EM, Pueschl D, Rennels A, Shah JB, Shilan JS, Wilhausen N, Vanderbeck AN. Science. 2021 Oct 14;eabm0829. PMID: 34648302
Corrigendum: Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients. Corrigendum: Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients. Giron LB, Dweep H, Yin X, Wang H, Damra M, Goldman AR, Gorman N, Palmer CS, Tang HY, Shaikh MW, Forsyth CB, Balk RA, Zilberstein NF, Liu Q, Kossenkov A, Keshavarzian A, Landay A, Abdel-Mohsen M. Front Immunol. 2021 Oct 4;12:779064. PMID: 34671365
Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model. Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model. Patel A, Walters JN, Reuschel EL, Schultheis K, Parzych E, Gary EN, Maricic I, Purwar M, Eblimit Z, Walker SN, Guimet D, Bhojnagarwala P, Adeniji OS, Doan A, Xu Z, Elwood D, Reeder SM, Pessaint L, Kim KY, Cook A, Chokkalingam N, Finneyfrock B, Tello-Ruiz E, Dodson A, Choi J, Generotti A, Harrison J, Tursi NJ, Andrade VM, Dia Y, Zaidi FI, Andersen H, Abdel-Mohsen M, Lewis MG, Muthumani K, Kim JJ, Kulp DW, Humeau LM, Ramos SJ, Smith TRF, Weiner DB, Broderick KE. Cell Rep Med. 2021 Oct 19;2(10):100420. PMID: 34604818 PMCID: PMC8479327
Thromboelastography profiles for controlled circulatory death donors: Validating the role of heparin. Crannell WC, Sally M, McConnell K, Connelly C, Maynard E, Dewey E, Abt P, Enestvedt CK. Clin Transplant. 2021 Oct 19:e14518. PMID: 34668240
A pragmatic outreach pilot to understand and overcome barriers to COVID-19 vaccination in abdominal organ transplant. Serper M, Liu CH, Blumberg EA, Burdzy AE, Veasey S, Halpern S, Lander E, Sigafus MR, Bloom RD, Dunn TB, Abt PL, Reddy KR, Mehta SJ. Transpl Infect Dis. 2021 Oct;23(5):e13722. PMID: 34496115
Implementation of FDG-PET/CT imaging methodology for quantification of inflammatory response in patients with locally advanced non-small cell lung cancer: results from the ACRIN 6668/RTOG 0235 trial. Jahangiri P, Dreyfuss AD, Duan F, Snyder BS, Borja AJ, Pournazari K, Kothekar E, Arani L, Al-Zaghal A, Seraj SM, Hancin EC, Pinheiro B, Werner TJ, Swisher-McClure S, Feigenberg SJ, Torigian DA, Revheim ME, Simone CB 2nd, Alavi A. 2021 Oct 15;11(5):415-427. PMID: 34754612
Tau-PET imaging as a molecular modality for Alzheimer's disease. Ayubcha C, Rigney G, Borja AJ, Werner T, Alavi A. Am J Nucl Med Mol Imaging. 2021 Oct 15;11(5):374-386. PMID: 34754608 PMCID: PMC8569333
Critical review of PET imaging for detection and characterization of the atherosclerotic plaques with emphasis on limitations of FDG-PET compared to NaF-PET in this setting. Alavi A, Werner TJ, Raynor W, Høilund-Carlsen PF, Revheim ME. Am J Nucl Med Mol Imaging. 2021 Oct 15;11(5):337-351. PMID: 34754605 PMCID: PMC8569336
Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models. Awasthi S, Knox JJ, Desmond A, Alameh MG, Gaudette BT, Lubinski JM, Naughton A, Hook LM, Egan KP, Tam YK, Pardi N, Allman D, Luning Prak ET, Cancro MP, Weissman D, Cohen GH, Friedman HM. J Clin Invest. 2021 Oct 7:e152310. PMID: 34618692
Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation. Gaudette BT, Roman CJ, Ochoa TA, Gómez Atria D, Jones DD, Siebel CW, Maillard I, Allman D. J Clin Invest. 2021 Oct 15;131(20):e151975. PMID: 34473651 PMCID: PMC8516456
Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection. Bjanes E, Sillas RG, Matsuda R, Demarco B, Fettrelet T, DeLaney AA, Kornfeld OS, Lee BL, Rodríguez López EM, Grubaugh D, Wynosky-Dolfi MA, Philip NH, Krespan E, Tovar D, Joannas L, Beiting DP, Henao-Mejia J, Schaefer BC, Chen KW, Broz P, Brodsky IE. PLoS Pathog. 2021 Oct 14;17(10):e1009967. PMID: 34648590
Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis. Sivakumar P, Ammar R, Thompson JR, Luo Y, Streltsov D, Porteous M, McCoubrey C, Cantu E 3rd, Beers MF, Jarai G, Christie JD. Respir Res. 2021 Oct 24;22(1):273. PMID: 34689792 PMCID: PMC8543878
Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments. Bhatta M, Shenoy GN, Loyall JL, Gray BD, Bapardekar M, Conway A, Minderman H, Kelleher RJ Jr, Carreno BM, Linette G, Shultz LD, Odunsi K, Balu-Iyer SV, Pak KY, Bankert RB. J Immunother Cancer. 2021 Oct;9(10):e003148. PMID: 34599030 PMCID: PMC8488709
Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort. Shah S, Halvorson A, McBay B, Dorn C, Wilson O, Tuteja S, Chang KM, Cho K, Hauger R, Suzuki A, Hunt C, Siew E, Matheny M, Hung A, Greevy R, Roumie C. Gut. 2021 Oct 18:gutjnl-2021-325701. PMID: 34663578
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. Verma A, Tsao NL, Thomann L, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford D, Efird JT, Huffman J, Hung A, Ivey KL, Levin M, Lynch J, Natarajan P, Pyarajan S, Bick A, Costa L, Genovese G, Hauger R, Madduri R, Pathak GA, Polimanti R, Voight B, Vujkovic M, Zekavat M, Zhao H, Ritchie MD; VA Million Veteran Program COVID-19 Science Initiative, Chang KM, Cho K, Casas JP, Tsao PS, Gaziano JM, O'Donnell C, Damrauer SM, Liao KP. medRxiv. 2021 Oct 6:2021.05.18.21257396. PMID: 34642702 PMCID: PMC8509103
A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease. Levin MG, Klarin D, Georgakis MK, Lynch J, Liao KP, Voight BF, O'Donnell CJ, Chang KM, Assimes TL, Tsao PS, Damrauer SM; VA Million Veteran Program. Circ Res. 2021 Oct 29;129(10):968-970. PMID: 34547901 PMCID: PMC8556352
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. Liu X, Verma A, Garcia G Jr, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2113401118. PMID: 34593624 PMCID: PMC8594528
Early post-lung transplant calcineurin inhibitor management varies widely: An international survey. Farrell CL, Miano TA, Griffiths S, Christie JD, Diamond JM, Shashaty MGS. Clin Transplant. 2021 Oct 13:e14510. PMID: 34643962
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia. Lam LKM, Murphy S, Kokkinaki D, Venosa A, Sherrill-Mix S, Casu C, Rivella S, Weiner A, Park J, Shin S, Vaughan AE, Hahn BH, Odom John AR, Meyer NJ, Hunter CA, Worthen GS, Mangalmurti NS. Sci Transl Med. 2021 Oct 20;13(616):eabj1008. PMID: 34669439

September 2021

The special unfolded protein response in plasma cells. Ricci D, Gidalevitz T, Argon Y. Immunol Rev. 2021 Sep;303(1):35-51. doi: 10.1111/imr.13012. Epub 2021 Aug 8 PMID: 34368957
Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial. Reich DS, Arnold DL, Vermersch P, Bar-Or A, Fox RJ, Matta A, Turner T, Wallström E, Zhang X, Mareš M, Khabirov FA, Traboulsee A; Tolebrutinib Phase 2b Study Group. Lancet Neurol. 2021 Sep;20(9):729-738. PMID: 34418400
Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, Kleinhenz ME, Golden JA, Sutter N, Tietje-Ulrich G, Criner RN, Arcasoy SM, Christie JD, Diamond J, Singer JP. Ann Am Thorac Soc. 2021 Sep;18(9):1464-1474. doi: 10.1513/AnnalsATS.202007-796OC. PMID: 33565917
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency. Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. PMID: 34358447
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates . Zabaleta N, Dai W, Bhatt U, Hérate C, Maisonnasse P, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Naninck T, Kahlaoui N, Lemaitre J, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Contreras V, Marlin R, Tsong Fang RH, Chapon C, van der Werf S, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Le Grand R, Vandenberghe LH. Cell Host Microbe. 2021 Sep 8;29(9):1437-1453.e8. doi: 10.1016/j.chom.2021.08.002. Epub 2021 Aug 7. PMID: 34428428
The mechanisms of smell loss after SARS-CoV-2 infection. Doty RL. Lancet Neurol. 2021 Sep;20(9):693-695. PMID: 34339627 PMCID: PMC8324112
A pragmatic outreach pilot to understand and overcome barriers to COVID-19 vaccination in abdominal organ transplant. Serper M, Liu CH, Blumberg EA, Burdzy AE, Veasey S, Halpern S, Lander E, Sigafus M, Bloom RD, Dunn T, Abt P, Reddy KR, Mehta SJ. Transpl Infect Dis. 2021 Sep 8. doi: 10.1111/tid.13722. Online ahead of print. PMID: 34496115
Pregnancy Outcomes After Living Liver Donation: A Multi-Institutional Study. Sonnenberg EM, Lee-Riddle GS, Walls DO, Caicedo JC, Jackson WE, Hughes L, Ladner DP, Liapakis A, Pomfret EA, Sarkar M, Selzner N, Torres AM, Abt PL, Olthoff KM. Liver Transpl. 2021 Sep;27(9):1262-1272. doi: 10.1002/lt.26098. Epub 2021 Jul 13. PMID: 33993632
Living Donor Liver Transplantation: Is Recipient Age a Barrier? Abu-Gazala S, Abt PL. Liver Transpl. 2021 Sep;27(9):1237-1238. doi: 10.1002/lt.26085. Epub 2021 Jul 31. PMID: 33905597
Occult Hepatocellular Carcinoma Associated With Transjugular Intrahepatic Portosystemic Shunts in Liver Transplant Recipients. Krumeich LN, Mancinelli J, Cucchiara A, Eddinger K, Aufhauser D Jr, Goldberg DW, Siegelman ES, Rosen M, Reddy KR, Hoteit M, Furth EE, Olthoff KM, Shaked A, Levine M, Abt P. Liver Transpl. 2021 Sep;27(9):1248-1261. doi: 10.1002/lt.26073. Epub 2021 Jul 21. PMID: 33853207 PMCID: PMC8429178
BLyS neutralization results in selective anti-HLA alloantibody depletion without successful desensitization. Agarwal D, Luning Prak ET, Bharani T, Everly M, Migone TS, Cancro M, Allman D, Choe I, Kearns JD, Trofe-Clark J, Naji A, Kamoun M. Transpl Immunol. 2021 Sep 7:101465. doi: 10.1016/j.trim.2021.101465. Online ahead of print. PMID: 34506905
Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation. Gaudette BT, Roman CJ, Ochoa TA, Gómez Atria D, Jones DD, Siebel CW, Maillard I, Allman D. J Clin Invest. 2021 Sep 2:151975. doi: 10.1172/JCI151975. Online ahead of print. PMID: 34473651
To build a plasma cell . Allman D. Immunol Rev. 2021 Sep;303(1):5-7. doi: 10.1111/imr.13017. Epub 2021 Aug 15. PMID: 34396544
The special unfolded protein response in plasma cells. Ricci D, Gidalevitz T, Argon Y. Immunol Rev. 2021 Sep;303(1):35-51. doi: 10.1111/imr.13012. Epub 2021 Aug 8. PMID: 34368957
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency. Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. PMID: 34358447
CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein-Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Response. Lee DSW, Yam JY, Grasmuck C, Dasoveanu D, Michel L, Ward LA, Rojas OL, Zandee S, Bourbonnière L, Ramaglia V, Bar-Or A, Prat A, Gommerman JL. J Immunol. 2021 Sep 15;207(6):1513-1521. doi: 10.4049/jimmunol.2001413. Epub 2021 Aug 16. PMID: 34400521
Long-term safety and efficacy of dimethyl fumarate for up to 13 years in patients with relapsing-remitting multiple sclerosis: Final ENDORSE study results. Gold R, Arnold DL, Bar-Or A, Fox RJ, Kappos L, Mokliatchouk O, Jiang X, Lyons J, Kapadia S, Miller C. Mult Scler. 2021 Sep 1:13524585211037909. doi: 10.1177/13524585211037909. Online ahead of print. PMID: 34465252
Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial . Reich DS, Arnold DL, Vermersch P, Bar-Or A, Fox RJ, Matta A, Turner T, Wallström E, Zhang X, Mareš M, Khabirov FA, Traboulsee A; Tolebrutinib Phase 2b Study Group. Lancet Neurol. 2021 Sep;20(9):729-738. doi: 10.1016/S1474-4422(21)00237-4. PMID: 34418400
Clinical Perspectives on the Molecular and Pharmacological Attributes of Anti-CD20 Therapies for Multiple Sclerosis. Bar-Or A, O'Brien SM, Sweeney ML, Fox EJ, Cohen JA. CNS Drugs. 2021 Sep;35(9):985-997. doi: 10.1007/s40263-021-00843-8. Epub 2021 Aug 9. PMID: 34370283
Siponimod: Disentangling disability and relapses in secondary progressive multiple sclerosis . Cree BA, Magnusson B, Rouyrre N, Fox RJ, Giovannoni G, Vermersch P, Bar-Or A, Gold R, Piani Meier D, Karlsson G, Tomic D, Wolf C, Dahlke F, Kappos L. Mult Scler. 2021 Sep;27(10):1564-1576. doi: 10.1177/1352458520971819. Epub 2020 Nov 18. PMID: 33205682
Pulmonary Outcomes After Autologous Stem Cell Transplant for Hodgkin Lymphoma. Davidow K, Bunin N, Goldfarb S, Li Y, Freedman JL. J Pediatr Hematol Oncol. 2021 Sep 6. doi: 10.1097/MPH.0000000000002301. Online ahead of print. PMID: 34486541
Endovascular cerebral aneurysm treatment volume during coronavirus 2019. Frank TS, Lee JE, Starke RM, Mokin M, Colby GP, Wang AC, Johnson J, Burkhardt JK, Srinivasan V, Raper DM, Albuquerque F, Kan P. Interv Neuroradiol. 2021 Sep 13:15910199211040278. doi: 10.1177/15910199211040278. Online ahead of print. PMID: 34515557
Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7. Guérin A, Roy NH, Kugler EM, Berry L, Burkhardt JK, Shin JB, Striepen B. Cell Host Microbe. 2021 Sep 8;29(9):1407-1420.e5. doi: 10.1016/j.chom.2021.07.002. Epub 2021 Aug 3. PMID: 34348092
Safety and efficacy of balloon-mounted stent in the treatment of symptomatic intracranial atherosclerotic disease: a multicenter experience. Mohammaden MH, Nogueira RG, Tekle W, Ortega-Gutierrez S, Farooqui M, Zevallos CB, Hanel RA, Cortez GM, Aghaebrahim A, Starke RM, Aref H, Elbassiouny A, Gamea A, Alaraj A, Sadeh M, Grigoryan M, Kuybu O, Haussen DC, Sheth SA, Maud A, Cordina SM, Tanweer O, Kan P, Burkhardt JK, Grandhi R, Siddiq F, Hassan AE. J Neurointerv Surg. 2021 Aug 4:neurintsurg-2021-017818. doi: 10.1136/neurintsurg-2021-017818. Online ahead of print. PMID: 34349013
Excess Serum Interleukin-18 Distinguishes Patients with Pathogenic Mutations in PSTPIP1. Stone DL, Ombrello A, Arostegui JI, Schneider C, Dang V, de Jesus A, Girard-Guyonvarc'h C, Gabay C, Lee W, Chae JJ, Aksentijevich I, Goldbach-Mansky RT, Kastner DL, Canna SW. Arthritis Rheumatol.2021 Sep 7. doi: 10.1002/art.41976. Online ahead of print. PMID: 34492165
Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia. Rapaport F, Neelamraju Y, Baslan T, Hassane D, Gruszczynska A, Robert de Massy M, Farnoud N, Haddox S, Lee T, Medina-Martinez J, Sheridan C, Thurmond A, Becker M, Bekiranov S, Carroll M, Moses Murdock H, Valk PJM, Bullinger L, D'Andrea R, Lowe SW, Neuberg D, Levine RL, Melnick A, Garrett-Bakelman FE. Leukemia. 2021 Sep;35(9):2688-2692. doi: 10.1038/s41375-021-01153-0. Epub 2021 Feb 12. PMID: 33580203
A genome-wide association meta-analysis identifies new Eosinophilic esophagitis loci. Chang X, March M, Mentch F, Nguyen K, Glessner J, Qu H, Liu Y, Furuta G, Aceves S, Gonsalves N, Nadeau K, Cianferoni A, Spergel J, Sleiman P, Hakonarson H. J Allergy Clin Immunol. 2021 Sep 7:S0091-6749(21)01358-0. doi: 10.1016/j.jaci.2021.08.018. Online ahead of print. PMID: 34506852
Oral Food Challenge for FPIES in Practice-A Survey: Report from the Work Group on FPIES Within the Adverse Reactions to Foods Committee, FAED IS, AAAAI. Nicolaides R, Bird JA, Cianferoni A, Brown-Whitehorn T, Nowak-Wegrzyn A. J Allergy Clin Immunol Pract. 2021 Sep 2:S2213-2198(21)00899-0. doi: 10.1016/j.jaip.2021.06.061. Online ahead of print. PMID: 34483087
The Role of the Environment in Eosinophilic Esophagitis. Cianferoni A, Jensen E, Davis CM. J Allergy Clin Immunol Pract. 2021 Sep;9(9):3268-3274. doi: 10.1016/j.jaip.2021.07.032. PMID: 34507708
Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Nat Immunol. 2021 Sep 29. doi: 10.1038/s41590-021-01057-2. Online ahead of print.
PMID: 34588688
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Lederer K, Parvathaneni K, Painter MM, Bettini E, Agarwal D, Lundgreen KA, Weirick M, Goel RR, Xu X, Drapeau EM, Gouma S, Greenplate AR, Coz CL, Romberg N, Jones L, Rosen M, Besharatian B, Kaminiski M, Weiskopf D, Sette A, Hensley SE, Bates P, Wherry EJ, Naji A, Bhoj V, Locci M. medRxiv. 2021 Sep 21:2021.09.16.21263686. doi: 10.1101/2021.09.16.21263686. Preprint.
PMID: 34580676
New-onset IgG autoantibodies in hospitalized patients with COVID-19. Chang SE, Feng A, Meng W, Apostolidis SA, Mack E, Artandi M, Barman L, Bennett K, Chakraborty S, Chang I, Cheung P, Chinthrajah S, Dhingra S, Do E, Finck A, Gaano A, Geßner R, Giannini HM, Gonzalez J, Greib S, Gündisch M, Hsu AR, Kuo A, Manohar M, Mao R, Neeli I, Neubauer A, Oniyide O, Powell AE, Puri R, Renz H, Schapiro J, Weidenbacher PA, Wittman R, Ahuja N, Chung HR, Jagannathan P, James JA, Kim PS, Meyer NJ, Nadeau KC, Radic M, Robinson WH, Singh U, Wang TT, Wherry EJ, Skevaki C, Luning Prak ET, Utz PJ. Nat Commun. 2021 Sep 14;12(1):5417. doi: 10.1038/s41467-021-25509-3. PMID: 34521836
Pembrolizumab for B-cell lymphomas relapsing after or refractory to CD19-directed CAR T-cell therapy. Chong EA, Alanio C, Svoboda J, Nasta SD, Landsburg DJ, Lacey SF, Ruella M, Bhattacharyya S, Wherry EJ, Schuster SJ. Blood. 2021 Sep 9:blood.2021012634. doi: 10.1182/blood.2021012634. Online ahead of print. PMID: 34496014
To build a plasma cell. Allman D. Immunol Rev. 2021 Sep;303(1):5-7. PMID: 34396544
Biochemical coordination of plasma cell genesis. Gaudette BT, Allman D. Immunol Rev. 2021 Sep;303(1):52-61. PMID: 34313339
Mitigating selection bias in organ allocation models. Schnellinger EM, Cantu E 3rd, Harhay MO, Schaubel DE, Kimmel SE, Stephens-Shields AJ. BMC Med Res Methodol. 2021 Sep 21;21(1):191. PMID: 34548017
Prospects for the Global Elimination of Hepatitis B. Block TM, Chang KM, Guo JT. Annu Rev Virol. 2021 Sep 29;8(1):437-458. PMID: 34586871
Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness. Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM. Crit Care Med. 2021 Sep 29. doi: 10.1097/CCM.0000000000005333. PMID: 34593707
COVID-19 Critical Illness: A Data-Driven Review. Ginestra JC, Mitchell OJL, Anesi GL, Christie JD. Annu Rev Med. 2021 Sep 14. doi: 10.1146/annurev-med-042420-110629. PMID: 34520220

August 2021

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Nat Immunol. 2021 Aug;22(8):1008-1019. doi: 10.1038/s41590-021-00975-5. Epub 2021 Jul 26. PMID: 34312545
Identification of Novel Neutralizing Monoclonal Antibodies against SARS-CoV-2 Spike Glycoprotein. Bordoloi D, Xu Z, Ho M, Purwar M, Bhojnagarwala P, Cassel J, Giron LB, Walker S, Kulkarni AJ, Ruiz ET, Choi J, Zaidi FI, Wu Y, Wang S, Patel A, Ramos S, Smith T, Kulp D, Ugen KE, Srinivasan A, Abdel-Mohsen M, Humeau L, Weiner DB, Muthumani K. ACS Pharmacol Transl Sci. 2021 Jul 29;4(4):1349-1361. PMID: 34396059 PMCID: PMC8353887
Center Variability in Acute Rejection and Biliary Complications after Pediatric Liver Transplantation. Kanneganti M, Xu Y, Huang YS, Kitt E, Fisher BT, Abt PL, Rand EB, Schaubel DE, Bittermann T. Liver Transpl. 2021 Aug 8. doi: 10.1002/lt.26259 PMID: 34365719
CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein-Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Response. Lee DSW, Yam JY, Grasmuck C, Dasoveanu D, Michel L, Ward LA, Rojas OL, Zandee S, Bourbonnière L, Ramaglia V, Bar-Or A, Prat A, Gommerman JL. J Immunol. 2021 Aug 16:ji2001413. PMID: 34400521
Clinical Perspectives on the Molecular and Pharmacological Attributes of Anti-CD20 Therapies for Multiple Sclerosis. Bar-Or A, O'Brien SM, Sweeney ML, Fox EJ, Cohen JA. CNS Drugs. 2021 Aug 9:1-13. PMID: 34370283
Vaccination and multiple sclerosis in the era of the COVID-19 pandemic. Monschein T, Hartung HP, Zrzavy T, Barnett M, Boxberger N, Berger T, Chataway J, Bar-Or A, Rommer PS, Zettl UK. J Neurol Neurosurg Psychiatry. 2021 Aug 5:jnnp-2021-326839. PMID: 34353858
Distinct Bioenergetic Features of Human Invariant Natural Killer T Cells Enable Retained Functions in Nutrient-Deprived States. Khurana P, Burudpakdee C, Grupp SA, Beier UH, Barrett DM, Bassiri H. Front Immunol. 2021 Aug 9;12:700374. PMID: 34434191 PMCID: PMC8380770
Skewed Cytokine Responses Rather Than the Magnitude of the Cytokine Storm May Drive Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children. Chang JC, Matsubara D, Morgan RW, Diorio C, Nadaraj S, Teachey DT, Bassiri H, Behrens EM, Banerjee A. J Am Heart Assoc. 2021 Aug 17;10(16):e021428. PMID: 34365798
The biological underpinnings of therapeutic resistance in pancreatic cancer. Beatty GL, Werba G, Lyssiotis CA, Simeone DM. Genes Dev. 2021 Jul 1;35(13-14):940-962. PMID: 34117095 PMCID: PMC8247606
Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury. Akimova T, Zhang T, Christensen LM, Wang Z, Han R, Negorev D, Samanta A, Sasson IE, Gaddapara T, Jiao J, Wang L, Bhatti TR, Levine MH, Diamond JM, Beier UH, Simmons RA, Cantu E, Wilkes DS, Lederer DJ, Anderson M, Christie JD, Hancock WW. Am J Respir Crit Care Med. 2021 Aug 4. PMID: 34346860
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates. Zabaleta N, Dai W, Bhatt U, Hérate C, Maisonnasse P, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Naninck T, Kahlaoui N, Lemaitre J, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Contreras V, Marlin R, Tsong Fang RH, Chapon C, van der Werf S, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Le Grand R, Vandenberghe LH. Cell Host Microbe. 2021 Aug 7:S1931-3128(21)00378-4. PMID: 34428428 PMCID: PMC8346325
Urine Lipoarabinomannan Testing in Adults With Advanced Human Immunodeficiency Virus in a Trial of Empiric Tuberculosis Therapy. Matoga MM, Bisson GP, Gupta A, Miyahara S, Sun X, Fry C, Manabe YC, Kumwenda J, Cecilia K, Nyirenda M, Ngongondo M, Mbewe A, Lagat D, Wallis C, Mugerwa H, Hosseinipour MC. Clin Infect Dis. 2021 Aug 16;73(4):e870-e877. PMID: 34398958 PMCID: PMC8366821
Memory B cells and plasma cells: The differentiative continuum of humoral immunity. Cancro MP, Tomayko MM. Immunol Rev. 2021 Sep;303(1):72-82. PMID: 34396546
Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ. Van Der Kraak LA, Schneider C, Dang V, Burr AHP, Weiss ES, Varghese JA, Yang L, Hand TW, Canna SW. Mucosal Immunol. 2021 Sep;14(5):1100-1112. PMID: 34103660
Lung Transplantation Outcomes after Crossing Low-Level Donor Specific Antibodies Without Planned Augmented Immunosuppression. Courtwright AM, Kamoun M, Diamond JM, Kearns J, Ahya VN, Christie JD, Clausen E, Hadjiliadis D, Patel N, Salgado JC, Cevasco M, Cantu EE, Crespo MM, Bermudez CA. Clin Transplant. 2021 Aug 8. PMID: 34365656
Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model. Kim MM, Verginadis II, Goia D, Haertter A, Shoniyozov K, Zou W, Maity A, Busch TM, Metz JM, Cengel KA, Dong L, Koumenis C, Diffenderfer ES. Cancers (Basel). 2021 Aug 23;13(16):4244. PMID: 34439398
American Association for the Study of Liver Diseases Expert Panel Consensus Statement: Vaccines to Prevent Coronavirus Disease 2019 Infection in Patients With Liver Disease. Fix OK, Blumberg EA, Chang KM, Chu J, Chung RT, Goacher EK, Hameed B, Kaul DR, Kulik LM, Kwok RM, McGuire BM, Mulligan DC, Price JC, Reau NS, Reddy KR, Reynolds A, Rosen HR, Russo MW, Schilsky ML, Verna EC, Ward JW, Fontana RJ; AASLD COVID-19 Vaccine Working Group. Hepatology. 2021 Aug;74(2):1049-1064. PMID: 33577086 PMCID: PMC8014184
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking. Chen H, Li Z, Feng S, Richard-Greenblatt M, Hutson E, Andrianus S, Glaser LJ, Rodino KG, Qian J, Jayaraman D, Collman RG, Glascock A, Bushman FD, Lee JS, Cherry S, Fausto A, Weiss SR, Koo H, Corby PM, Oceguera A, O'Doherty U, Garfall AL, Vogl DT, Stadtmauer EA, Wang P. Clin Chem. 2021 Aug 12:hvab158. PMID: 34383886
Multiplexed detection of SARS-CoV-2 genomic and subgenomic RNA using in situ hybridization. Acheampong KK, Schaff DL, Emert BL, Lake J, Reffsin S, Shea EK, Comar CE, Litzky LA, Khurram NA, Linn RL, Feldman M, Weiss SR, Montone KT, Cherry S, Shaffer SM. bioRxiv. 2021 Aug 11:2021.08.11.455959. PMID: 34401878
Redondovirus diversity and evolution on global, individual, and molecular scales. Taylor LJ, Dothard MI, Rubel MA, Allen AA, Hwang Y, Roche AM, Graham-Wooten J, Fitzgerald AS, Khatib LA, Ranciaro A, Thompson SR, Beggs WR, Campbell MC, Mokone GG, Mpoloka SW, Fokunang C, Njamnshi AK, Mbunwe E, Woldemeskel D, Belay G, Nyambo T, Tishkoff SA, Collman RG, Bushman FD. J Virol. 2021 Aug 18:JVI0081721. PMID: 34406857
Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome. Merenstein C, Liang G, Whiteside SA, Cobián-Güemes AG, Merlino MS, Taylor LJ, Glascock A, Bittinger K, Tanes C, Graham-Wooten J, Khatib LA, Fitzgerald AS, Reddy S, Baxter AE, Giles JR, Oldridge DA, Meyer NJ, Wherry EJ, McGinniss JE, Bushman FD, Collman RG. mBio. 2021 Aug 17:e0177721. PMID: 34399607
The lung microbiome: progress and promise. Whiteside SA, McGinniss JE, Collman RG. J Clin Invest. 2021 Aug 2;131(15):e150473. PMID: 34338230 PMCID: PMC8321564
The lung microbiome in lung transplantation. McGinniss JE, Whiteside SA, Simon-Soro A, Diamond JM, Christie JD, Bushman FD, Collman RG. J Heart Lung Transplant. 2021 Aug;40(8):733-744. PMID: 34120840 PMCID: PMC8335643
Phase II Study of Maintenance Rucaparib in Patients With Platinum-Sensitive Advanced Pancreatic Cancer and a Pathogenic Germline or Somatic Variant in BRCA1, BRCA2, or PALB2. Reiss KA, Mick R, O'Hara MH, Teitelbaum U, Karasic TB, Schneider C, Cowden S, Southwell T, Romeo J, Izgur N, Hannan ZM, Tondon R, Nathanson K, Vonderheide RH, Wattenberg MM, Beatty G, Domchek SM. J Clin Oncol. 2021 Aug 1;39(22):2497-2505. doi: 10.1200/JCO.21.00003. Epub 2021 May 10. PMID: 33970687
Interpretative differences of combined cytogenetic and molecular profiling highlights differences between MRC and ELN classifications of AML. Sussman RT, Manning B, Ackerman D, Bigdeli A, Pammer P, Velu PD, Luger SM, Bagg A, Carroll M, Morrissette JJD. Cancer Genet. 2021 Aug;256-257:68-76. doi: 10.1016/j.cancergen.2021.04.004. Epub 2021 Apr 16. PMID: 33915454
Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model. Kim MM, Verginadis II, Goia D, Haertter A, Shoniyozov K, Zou W, Maity A, Busch TM, Metz JM, Cengel KA, Dong L, Koumenis C, Diffenderfer ES. Cancers (Basel). 2021 Aug 23;13(16):4244. doi: 10.3390/cancers13164244. PMID: 34439398
Hepatitis B e antigen loss in adults and children with chronic hepatitis B living in North America: A prospective cohort study. Lee WM, King WC, Janssen HLA, Ghany MG, Fontana RJ, Fried M, Sterling RK, Feld JJ, Wang J, Mogul DB, Cooper SL, Bisceglie AMD; Hepatitis B Research Network (HBRN) .J Viral Hepat. 2021 Aug 6. doi: 10.1111/jvh.13591. Online ahead of print. PMID: 34355475
Set Up for Failure: Pre-Existing Autoantibodies in Lung Transplant. McQuiston A, Emtiazjoo A, Angel P, Machuca T, Christie J, Atkinson C. Front Immunol. 2021 Aug 11;12:711102. doi: 10.3389/fimmu.2021.711102. eCollection 2021. PMID: 34456920
Oral delivery of therapeutic proteins bioencapsulated in plant cells: preclinical and clinical advances . Khan I, Daniell H. Curr Opin Colloid Interface Sci. 2021 Aug;54:101452. doi: 10.1016/j.cocis.2021.101452. Epub 2021 Mar 24. PMID: 33967586
A Randomized Phase 2 Study Of Nivolumab Monotherapy Or Nivolumab Combined with Ipilimumab In Patients with Advanced Gastrointestinal Stromal Tumors. Singh AS, Hecht JR, Rosen L, Wainberg ZA, Wang X, Douek M, Hagopian A, Andes R, Sauer L, Brackert SR, Chow W, DeMatteo R, Eilber FC, Glaspy JA, Chmielowski B. Clin Cancer Res. 2021 Aug 18:clincanres.0878.2021. doi: 10.1158/1078-0432.CCR-21-0878. Online ahead of print. PMID: 34407970
What is the patient experience of surgical care during the coronavirus disease 2019 (COVID-19) pandemic? A mixed-methods study at a single institution . Shannon AB, Roberson JL, Clapp JT, Vaughan C, Kleid M, Song Y, Miura JT, Dempsey DT, DeMatteo RP, Fleisher LA, Karakousis GC. Surgery. 2021 Aug;170(2):550-557. doi: 10.1016/j.surg.2020.12.031. Epub 2020 Dec 29. PMID: 33715849
Sex Differences in Cardiovascular Outcomes in CKD: Findings From the CRIC Study. Toth-Manikowski SM, Yang W, Appel L, Chen J, Deo R, Frydrych A, Krousel-Wood M, Rahman M, Rosas SE, Sha D, Wright J, Daviglus ML, Go AS, Lash JP, Ricardo AC; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Am J Kidney Dis. 2021 Aug;78(2):200-209.e1. doi: 10.1053/j.ajkd.2021.01.020. Epub 2021 Apr 20. PMID: 33857532

July 2021

Trends in Liver Transplantation for Acute Alcohol-Associated Hepatitis During the COVID-19 Pandemic in the US. Bittermann T, Mahmud N, Abt P. JAMA Netw Open. 2021 Jul 1;4(7):e2118713. doi: 10.1001/jamanetworkopen.2021.18713. PMID: 34323988
Biochemical coordination of plasma cell genesis. Gaudette BT, Allman D. Immunol Rev. 2021 Jul 26. doi: 10.1111/imr.12992. Online ahead of print. PMID: 34313339 Review.
An Open-Source Toolkit To Expand Bioinformatics Training in Infectious Diseases. Berry ASF, Farias Amorim C, Berry CL, Syrett CM, English ED, Beiting DP. mBio. 2021 Jul 6:e0121421. doi: 10.1128/mBio.01214-21. Online ahead of print. PMID: 34225494
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells. Di Giorgio E, Wang L, Xiong Y, Christensen LM, Akimova T, Han R, Samanta A, Trevisanut M, Brancolini C, Beier UH, Hancock WW. Front Immunol.2021 Jul 5;12:703632. doi: 10.3389/fimmu.2021.703632. eCollection 2021. PMID: 34290714 PMCID: PMC8287581
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling. Chen KW, Demarco B, Ramos S, Heilig R, Goris M, Grayczyk JP, Assenmacher CA, Radaelli E, Joannas LD, Henao-Mejia J, Tacchini-Cottier F, Brodsky IE, Broz P. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2101189118. doi: 10.1073/pnas.2101189118. PMID: 34260403 PMCID: PMC8285957
Immune Dysregulation in Human ITCH Deficiency Successfully Treated with Hematopoietic Cell Transplantation. Patel T, Henrickson SE, Moser EK, Field NS, Maurer K, Dawany N, Conrad M, Bunin N, Freedman JL, Heimall J, Arnold DE, Wang J, Markowitz JE, Payne-Poff SB, Williams KW, Russo PA, Wherry EJ, Devoto M, Oliver P, Sullivan KE, Kelsen JR. J Allergy Clin Immunol Pract. 2021 Jul;9(7):2885-2893.e3. doi: 10.1016/j.jaip.2021.04.010. Epub 2021 Apr 21. PMID: 33894394
Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting. Bear AS, Blanchard T, Cesare J, Ford MJ, Richman LP, Xu C, Baroja ML, McCuaig S, Costeas C, Gabunia K, Scholler J, Posey AD Jr, O'Hara MH, Smole A, Powell DJ Jr, Garcia BA, Vonderheide RH, Linette GP, Carreno BM. Nat Commun. 2021 Jul 16;12(1):4365. doi: 10.1038/s41467-021-24562-2. PMID: 34272369 PMCID: PMC8285372
FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Velalopoulou A, Karagounis IV, Cramer GM, Kim MM, Skoufos G, Goia D, Hagan S, Verginadis II, Shoniyozov K, Chiango J, Cerullo M, Varner K, Yao L, Qin L, Hatzigeorgiou AG, Minn AJ, Putt M, Lanza M, Assenmacher CA, Radaelli E, Huck J, Diffenderfer E, Dong L, Metz J, Koumenis C, Cengel KA, Maity A, Busch TM. Cancer Res. 2021 Jul 28:canres.1500.2021. doi: 10.1158/0008-5472.CAN-21-1500. Online ahead of print. PMID: 34321243
Adjuvant Photodynamic Therapy, Mediated via Topical Versus Systemic Administration of 5-Aminolevulinic Acid for Control of Murine Mammary Tumor after Surgical Resection†. Carter S, Miller J, Cramer G, Yuan M, Guzman S, Putt ME, Cengel KA, Freedman GM, Busch TM. Photochem Photobiol. 2021 Jul 5. doi: 10.1111/php.13482. Online ahead of print. PMID: 34224156
Characterization of a high-resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery. Zou W, Diffenderfer ES, Ota K, Boisseau P, Kim MM, Cai Y, Avery SM, Carlson DJ, Wiersma RD, Lin A, Koumenis C, Cengel KA, Metz JM, Dong L, Teo BK. Med Phys. 2021 Jul;48(7):3948-3957. doi: 10.1002/mp.14882. Epub 2021 Jun 3. PMID: 33843065
RNA sequencing identifies global transcriptional changes in peripheral CD4+ cells during active oesophagitis and following epicutaneous immunotherapy in eosinophilic oesophagitis. Ruffner MA, Zhang Z, Maurer K, Muir AB, Cianferoni A, Sullivan KE, Spergel JM. Clin Transl Immunology. 2021 Jul 22;10(7):e1314. doi: 10.1002/cti2.1314. eCollection 2021. PMID: 34322233
Erythrocytes Identify Complement Activation in Patients with COVID-19. Lam LM, Reilly JP, Rux AH, Murphy S, Kuri-Cervantes L, Weisman A, Ittner CA, Pampena MB, Betts M, Wherry EJ, Song WC, Lambris JD, Meyer NJ, Cines DB, Mangalmurti NS. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 7. doi: 10.1152/ajplung.00231.2021. Online ahead of print. PMID: 34231390
COVID-19 vaccination and immune thrombocytopenia. Pishko AM, Bussel JB, Cines DB. Nat Med. 2021 Jul;27(7):1145-1146. doi: 10.1038/s41591-021-01419-1. PMID: 34108715
Alpha-defensins: risk factor for thrombosis in COVID-19 infection. Abdeen S, Bdeir K, Abu-Fanne R, Maraga E, Higazi M, Khurram N, Feldman M, Deshpande C, Litzky LA, Heyman SN, Montone KT, Cines DB, Higazi AA. Br J Haematol. 2021 Jul;194(1):44-52. doi: 10.1111/bjh.17503. Epub 2021 May 30. PMID: 34053084
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Du M, Garcia JGN, Christie JD, Xin J, Cai G, Meyer NJ, Zhu Z, Yuan Q, Zhang Z, Su L, Shen S, Dong X, Li H, Hutchinson JN, Tejera P, Lin X, Wang M, Chen F, Christiani DC. Intensive Care Med.2021 Jul;47(7):761-771. doi: 10.1007/s00134-021-06410-5. Epub 2021 May 25. PMID: 34032881
Comparative safety of dipeptidyl peptidase-4 inhibitors and sudden cardiac arrest and ventricular arrhythmia: Population-based cohort studies. Dawwas GK, Hennessy S, Brensinger CM, Deo R, Bilker WB, Soprano SE, Dhopeshwarkar N, Flory JH, Bloomgarden ZT, Aquilante CL, Kimmel SE, Leonard CE. Clin Pharmacol Ther. 2021 Jul 31. doi: 10.1002/cpt.2381. Online ahead of print. PMID: 34331322
Number of opioid overdoses and depression as a predictor of suicidal thoughts. Brown LA, Denis CM, Leon A, Blank MB, Douglas SD, Morales KH, Crits-Christoph PF, Metzger DS, Evans DL. Drug Alcohol Depend. 2021 Jul 1;224:108728. doi: 10.1016/j.drugalcdep.2021.108728. Epub 2021 Apr 24. PMID: 33971515
HIV Infection and Depression Among Opiate Users in a US Epicenter of the Opioid Epidemic. Denis CM, Dominique T, Smith P, Fiore D, Ku YC, Culhane A, Dunbar D, Brown D, Daramay M, Voytek C, Morales KH, Blank MB, Crits-Christoph PF, Douglas SD, Spitsin S, Frank I, Colon-Rivera K, Montaner LJ, Metzger DS, Evans DL. AIDS Behav. 2021 Jul;25(7):2230-2239. doi: 10.1007/s10461-020-03151-2. Epub 2021 Jan 15. PMID: 33449236
DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells. Lim JY, Duttke SH, Baker TS, Lee J, Gambino KJ, Venturini NJ, Ho JSY, Zheng S, Fstkchyan YS, Pillai V, Fajgenbaum DC, Marazzi I, Benner C, Byun M. J Exp Med. 2021 Jul 5;218(7):e20202733. doi: 10.1084/jem.20202733. Epub 2021 May 10. PMID: 33970190
Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease. Nishimura Y, Fajgenbaum DC, Pierson SK, Iwaki N, Nishikori A, Kawano M, Nakamura N, Izutsu K, Takeuchi K, Nishimura MF, Maeda Y, Otsuka F, Yoshizaki K, Oksenhendler E, van Rhee F, Sato Y. Am J Hematol. 2021 Jul 15. doi: 10.1002/ajh.26292. Online ahead of print. PMID: 34265103
Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate. Mehta P, Fajgenbaum DC. Curr Opin Rheumatol. 2021 Jul 15. doi: 10.1097/BOR.0000000000000822. Online ahead of print. PMID: 34264880
Commentary: "Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and Its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing. Lucas A, Eberwine JH, Bagley SJ, Fan Y, Nasrallah MP, Brem S. Neurosurgery. 2021 Jul 31:nyab288. doi: 10.1093/neuros/nyab288. Online ahead of print. PMID: 34332498
18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Following Chimeric Antigen Receptor T-cell Therapy in Large B-cell Lymphoma. Ruff A, Ballard HJ, Pantel AR, Namoglu EC, Hughes ME, Nasta SD, Chong EA, Bagg A, Ruella M, Farwell MD, Svoboda J, Sellmyer MA. Mol Imaging Biol. 2021 Jul 6. doi: 10.1007/s11307-021-01627-8. Online ahead of print. PMID: 34231105
Clinical features and outcome of acquired myasthenia gravis in 94 dogs. Forgash JT, Chang YM, Mittelman NS, Petesch S, Benedicenti L, Galban E, Hammond JJ, Glass EN, Barker JR, Shelton GD, Luo J, Garden OA. J Vet Intern Med. 2021 Jul 31. doi: 10.1111/jvim.16223. Online ahead of print. PMID: 34331481
Subclinical Liver Disease is Associated with Subclinical Atherosclerosis in Psoriasis: Results from Two Observational Studies. Gonzalez-Cantero A, Teklu M, Sorokin AV, Prussick R, González-Cantero J, Martin-Rodriguez JL, Patel N, Parel PM, Manyak GA, Teague HL, Rodante JA, Keel A, Pérez-Hortet C, Sanchéz-Moya AI, Jiménez N, Ballester A, Solis J, Fernandez-Friera L, Barderas MG, Gonzalez-Calvin JL, Jaen P, Playford MP, Dey AK, Gelfand JM, Mehta NN. J Invest Dermatol. 2021 Jul 19:S0022-202X(21)01461-5. doi: 10.1016/j.jid.2021.05.034. Online ahead of print. PMID: 34293354
Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors. Guidon AC, Burton LB, Chwalisz BK, Hillis J, Schaller TH, Amato AA, Betof Warner A, Brastianos PK, Cho TA, Clardy SL, Cohen JV, Dietrich J, Dougan M, Doughty CT, Dubey D, Gelfand JM, Guptill JT, Johnson DB, Juel VC, Kadish R, Kolb N, LeBoeuf NR, Linnoila J, Mammen AL, Martinez-Lage M, Mooradian MJ, Naidoo J, Neilan TG, Reardon DA, Rubin KM, Santomasso BD, Sullivan RJ, Wang N, Woodman K, Zubiri L, Louv WC, Reynolds KL J Immunother Cancer. 2021 Jul;9(7):e002890. doi: 10.1136/jitc-2021-002890. PMID: 34281989 PMCID: PMC8291304
Disabling the Nuclear Translocalization of RelA/NF-κB by a Small Molecule Inhibits Triple-Negative Breast Cancer Growth. Kanzaki H, Chatterjee A, Hossein Nejad Ariani H, Zhang X, Chung S, Deng N, Ramanujan VK, Cui X, Greene MI, Murali R. Breast Cancer (Dove Med Press). 2021 Jul 5;13:419-430. doi: 10.2147/BCTT.S310231. eCollection 2021. PMID: 34262338 PMCID: PMC8275049
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion. Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobsen EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T. Science. 2021 Jul 30;373(6554):eabd2893. doi: 10.1126/science.abd2893. PMID: 34326208
Integrin Crosstalk Modulates Stiffness-independent Motility of CD4+ T Lymphocytes. Kim SHJ, Hammer DA. Mol Biol Cell. 2021 Jul 7:mbcE21030131. doi: 10.1091/mbc.E21-03-0131. Online ahead of print. PMID: 34232700
Health care worker sero-monitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration. Gouma S, Weirick ME, Bolton MJ, Arevalo CP, Goodwin EC, Anderson EM, McAllister CM, Christensen SR, Dunbar D, Fiore D, Brock A, Weaver J, Millar JS, DerOhannessian S, Frank I, Rader DJ, Wherry EJ, Hensley SE. JCI Insight. 2021 Jul 8:150449. doi: 10.1172/jci.insight.150449. Online ahead of print. PMID: 34237028
Immune Dysregulation in Human ITCH Deficiency Successfully Treated with Hematopoietic Cell Transplantation. Patel T, Henrickson SE, Moser EK, Field NS, Maurer K, Dawany N, Conrad M, Bunin N, Freedman JL, Heimall J, Arnold DE, Wang J, Markowitz JE, Payne-Poff SB, Williams KW, Russo PA, Wherry EJ, Devoto M, Oliver P, Sullivan KE, Kelsen JR. J Allergy Clin Immunol Pract. 2021 Jul;9(7):2885-2893.e3. doi: 10.1016/j.jaip.2021.04.010. Epub 2021 Apr 21. PMID: 33894394
Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma. Karmacharya MB, Sultan LR, Hunt SJ, Sehgal CM. Sci Rep. 2021 Jul 30;11(1):15553. doi: 10.1038/s41598-021-94323-0. PMID: 34330960 PMCID: PMC8324788
Demographic Trends in Female Interventional Radiology Trainees With the Advent of the Integrated Interventional Radiology Residency. Parikh RS, Shamimi-Noori S, Reddy S, Gade T, Nadolski GJ, Hunt SJ. J Am Coll Radiol. 2021 Jul 8:S1546-1440(21)00546-9. doi: 10.1016/j.jacr.2021.06.016. Online ahead of print. PMID: 34246646
Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells. Thakur A, Scholler J, Kubicka E, Bliemeister ET, Schalk DL, June CH, Lum LG. Front Immunol. 2021 Jul 5;12:690437. doi: 10.3389/fimmu.2021.690437. eCollection 2021. PMID: 34290709 PMCID: PMC8288104
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling. Sharma P, Yadav SK, Shah SD, Javed E, Lim JM, Pan S, Nayak AP, Panettieri RA Jr, Penn RB, Kambayashi T, Deshpande DA. Am J Respir Cell Mol Biol. 2021 Jul 22. doi: 10.1165/rcmb.2021-0106OC. Online ahead of print. PMID: 34293268
Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase. Yadav SK, Sharma P, Shah SD, Panettieri RA, Kambayashi T, Penn RB, Deshpande DA. J Cell Physiol. 2021 Jul 18. doi: 10.1002/jcp.30528. Online ahead of print. PMID: 34278583
Identifying Patients at Highest Risk of Remaining Unvaccinated against SARS-CoV-2 in a Large Veterans Health Administration Cohort. Mahmud N, Chapin SE, Kaplan DE, Marina S. Liver Transpl. 2021 Jul 22. doi: 10.1002/lt.26235. Online ahead of print. PMID: 34293247
Risk Prediction Models for Postoperative Decompensation and Infection in Patients With Cirrhosis: A Veterans Affairs Cohort Study. Mahmud N, Fricker Z, Lewis JD, Taddei TH, Goldberg DS, Kaplan DE. Clin Gastroenterol Hepatol. 2021 Jul 8:S1542-3565(21)00721-7. doi: 10.1016/j.cgh.2021.06.050. Online ahead of print. PMID: 34246794
Impact of SGLT2 inhibitors in comparison with DPP4 inhibitors on ascites and death in veterans with cirrhosis on metformin. Saffo S, Kaplan DE, Mahmud N, Serper M, John BV, Ross JS, Taddei T. Diabetes Obes Metab. 2021 Jul 6. doi: 10.1111/dom.14488. Online ahead of print. PMID: 34227216
Genetics of HLA Peptide Presentation and Impact on Outcomes in HLA-Matched Allogeneic Hematopoietic Cell Transplantation. Story CM, Wang T, Bhatt VR, Battiwalla M, Badawy SM, Kamoun M, Gragert L, Brown V, Baxter-Lowe LA, Marsh SGE, Gadalla SM, Schetelig J, Mytilineos J, Miklos D, Waller EK, Kuxhausen M, Spellman S, Lee S, Paczesny S, Lansford JL, Vincent BG, Riches ML, Armistead PM; Center for International Blood and Marrow Transplant Research Immunobiology Working Committee. Transplant Cell Ther. 2021 Jul;27(7):591-599. doi: 10.1016/j.jtct.2021.04.003. Epub 2021 Apr 18. PMID: 33882342 PMCID: PMC8343993
An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement. O'Donnell JC, Purvis EM, Helm KVT, Adewole DO, Zhang Q, Le AD, Cullen DK. Commun Biol. 2021 Jul 15;4(1):879. doi: 10.1038/s42003-021-02392-8. PMID: 34267315 PMCID: PMC8282659
TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells. Garcia de Mattos Barbosa M, Lefferts AR, Huynh D, Liu H, Zhang Y, Fu B, Barnes J, Samaniego M, Bram RJ, Geha R, Shikanov A, Luning Prak ET, Farkash EA, Platt JL, Cascalho M. JCI Insight. 2021 Jul 20:150483. doi: 10.1172/jci.insight.150483. Online ahead of print. PMID: 34283811
Advancing precision medicine for acute respiratory distress syndrome. Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Lancet Respir Med. 2021 Jul 23:S2213-2600(21)00157-0. doi: 10.1016/S2213-2600(21)00157-0. Online ahead of print. PMID: 34310901 PMCID: PMC8302189
The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU. Prasad N, Grossestreuer AV, Meyer NJ, Perman SM, Mikkelsen ME, Hollander J, Gaieski DF. Sci Rep. 2021 Jul 23;11(1):15114. doi: 10.1038/s41598-021-94473-1. PMID: 34302025
Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate with Organ Dysfunction and Mortality in Sepsis. Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Weisman AR, Agyekum R, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ. Shock. 2021 Jul 8. doi: 10.1097/SHK.0000000000001833. Online ahead of print. PMID: 34265829
Acute respiratory distress syndrome. Meyer NJ, Gattinoni L, Calfee CS. Lancet. 2021 Jul 1:S0140-6736(21)00439-6. doi: 10.1016/S0140-6736(21)00439-6. Online ahead of print. PMID: 34217425
Developing a composite outcome tool to measure response to treatment in ANCA-associated vasculitis: A mixed methods study from OMERACT 2020. Quinn KA, Monti S, Christensen R, Jayne D, Langford CA, Lanier GE, Mahr A, Pagnoux C, Shea B, Tugwell P, Viðarsdóttir MB, Tomasson G, Merkel PA. Semin Arthritis Rheum. 2021 Jul 8:S0049-0172(21)00125-6. doi: 10.1016/j.semarthrit.2021.07.001. Online ahead of print. PMID: 34274125
BCL6 BTB-specific inhibitor reversely represses T Cell activation, Tfh cells differentiation and germinal center reaction in vivo. Cai Y, Poli ANR, Vadrevu S, Gyampoh K, Hart C, Ross B, Fair M, Xue F, Salvino JM, Montaner LJ. Eur J Immunol. 2021 Jul 21. doi: 10.1002/eji.202049150. Online ahead of print. PMID: 34287839
Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies. Poussin M, Sereno A, Wu X, Huang F, Manro J, Cao S, Carpenito C, Glasebrook A, Powell DJ Jr, Demarest S. J Immunother Cancer. 2021 Jul;9(7):e002444. doi: 10.1136/jitc-2021-002444. PMID: 34253637 PMCID: PMC8276301
Letter to the Editor in response to "Response to Kovanen PT, et al. Letter to the Editor" for original article COVID-19 increases risk of myocardial infarction in persons with familial hypercholesterolemia with or without ASCVD. Myers KD, Wilemon K, McGowan MP, Howard W, Staszak D, Rader DJ. Am J Prev Cardiol. 2021 Sep;7:100225. doi: 10.1016/j.ajpc.2021.100225. Epub 2021 Jul 20. PMID: 34308404
Associations of HDL metrics with coronary artery calcium score and density among women traversing menopause. El Khoudary SR, Nasr A, Matthews KA, Orchard TJ, Brooks MM, Billheimer J, McConnell D, Janssen I, Everson-Rose SA, Crawford S, Rader DJ. J Lipid Res. 2021 Jul 22:100098. doi: 10.1016/j.jlr.2021.100098. Online ahead of print. PMID: 34303684
A Genome-First Approach to Rare Variants in Dominant Postlingual Hearing Loss Genes in a Large Adult Population. Ahmadmehrabi S, Li B, Hui D, Park J, Ritchie M, Rader DJ, Ruckenstein MJ, Epstein DJ, Brant J. Otolaryngol Head Neck Surg. 2021 Jul 20:1945998211029544. doi: 10.1177/01945998211029544. Online ahead of print. PMID: 34281439
A genome-first approach to mortality and metabolic phenotypes in MTARC1 p.Ala165Thr (rs2642438) heterozygotes and homozygotes. Schneider CV, Schneider KM, Conlon DM, Park J, Vujkovic M, Zandvakili I, Ko YA, Trautwein C, Center R, Carr RM, Strnad P, Thaiss CA, Rader DJ. Med (N Y). 2021 Jul 9;2(7):851-863.e3. doi: 10.1016/j.medj.2021.04.011. PMID: 34258604
Understanding VITT(ual) reality. Rauova L, Poncz M. Blood. 2021 Jul 29;138(4):285-286. doi: 10.1182/blood.2021012524. PMID: 34323943 PMCID: PMC8320444
COVID-19 vaccination: possible short-term exacerbations of oral mucosal diseases. Kulkarni R, Sollecito TP. Int J Dermatol. 2021 Jul 12. doi: 10.1111/ijd.15779. Online ahead of print. PMID: 34251026
Management of Eosinophilic Esophagitis During Oral Immunotherapy. Chu DK, Spergel JM, Vickery BP. J Allergy Clin Immunol Pract. 2021 Jul 26:S2213-2198(21)00818-7. doi: 10.1016/j.jaip.2021.07.017. Online ahead of print. PMID: 34325036
Development of the Child- and Parent-Rated Scales of Food Allergy Anxiety (SOFAA). Dahlsgaard KK, Wilkey LK, Stites SD, Lewis MO, Spergel JM. J Allergy Clin Immunol Pract. 2021 Jul 12:S2213-2198(21)00770-4. doi: 10.1016/j.jaip.2021.06.039. Online ahead of print. PMID: 34265450
Ruxolitinib: Targeted Approach for Treatment of Autoinflammatory Very Early Onset- Inflammatory Bowel Disease. Rudra S, Shaul E, Conrad M, Patel T, Moore A, Dawany N, Canavan MC, Sullivan KE, Behrens E, Kelsen JR. Clin Gastroenterol Hepatol. 2021 Jul 27:S1542-3565(21)00822-3. doi: 10.1016/j.cgh.2021.07.040. Online ahead of print. PMID: 34329777
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients. Le Coz C, Nguyen DN, Su C, Nolan BE, Albrecht AV, Xhani S, Sun D, Demaree B, Pillarisetti P, Khanna C, Wright F, Chen PA, Yoon S, Stiegler AL, Maurer K, Garifallou JP, Rymaszewski A, Kroft SH, Olson TS, Seif AE, Wertheim G, Grant SFA, Vo LT, Puck JM, Sullivan KE, Routes JM, Zakharova V, Shcherbina A, Mukhina A, Rudy NL, Hurst ACE, Atkinson TP, Boggon TJ, Hakonarson H, Abate AR, Hajjar J, Nicholas SK, Lupski JR, Verbsky J, Chinn IK, Gonzalez MV, Wells AD, Marson A, Poon GMK, Romberg N. J Exp Med. 2021 Jul 5;218(7):e20201750. doi: 10.1084/jem.20201750. Epub 2021 May 5. PMID: 33951726 PMCID: PMC8105723
Identification of 22 susceptibility loci associated with testicular germ cell tumors. Pluta J, Pyle LC, Nead KT, Wilf R, Li M, Mitra N, Weathers B, D'Andrea K, Almstrup K, Anson-Cartwright L, Benitez J, Brown CD, Chanock S, Chen C, Cortessis VK, Ferlin A, Foresta C, Gamulin M, Gietema JA, Grasso C, Greene MH, Grotmol T, Hamilton RJ, Haugen TB, Hauser R, Hildebrandt MAT, Johnson ME, Karlsson R, Kiemeney LA, Lessel D, Lothe RA, Loud JT, Loveday C, Martin-Gimeno P, Meijer C, Nsengimana J, Quinn DI, Rafnar T, Ramdas S, Richiardi L, Skotheim RI, Stefansson K, Turnbull C, Vaughn DJ, Wiklund F, Wu X, Yang D, Zheng T, Wells AD, Grant SFA, Rajpert-De Meyts E, Schwartz SM, Bishop DT, McGlynn KA, Kanetsky PA, Nathanson KL; Testicular Cancer Consortium. Nat Commun. 2021 Jul 23;12(1):4487. doi: 10.1038/s41467-021-24334-y. PMID: 34301922
A Multidisciplinary Collaborative Approach to Retinal Toxic Effects Screening for Dermatology Patients Taking Antimalarials. Fett N, Werth VP. JAMA Dermatol. 2021 Jul 28. doi: 10.1001/jamadermatol.2021.2699. Online ahead of print. PMID: 34319351
Subsetting the subsets: Heterogeneity and developmental relationships of T cells in human tumors. Alanio C, Wherry EJ. Sci Immunol. 2021 Jul 23;6(61):eabj3067. doi: 10.1126/sciimmunol.abj3067. PMID: 34301801
A statistical framework for differential pseudotime analysis with multiple single-cell RNA-seq samples. Hou W, Ji Z, Chen Z, Wherry EJ, Hicks SC, Ji H. bioRxiv. 2021 Jul 12:2021.07.10.451910. doi: 10.1101/2021.07.10.451910. Preprint. PMID: 34282418 PMCID: PMC8288148
Changes in Neuronal Activity in the Anterior Cingulate Cortex and Primary Somatosensory Cortex With Nonlinear Burst and Tonic Spinal Cord Stimulation. Quindlen-Hotek JC, Kent AR, De Anda P, Kartha S, Benison AM, Winkelstein BA. Neuromodulation. 2020 Jul;23(5):594-604. doi: 10.1111/ner.13116. Epub 2020 Feb 6. PMID: 32027444 PMCID: PMC7771032
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency. Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Mol Cell. 2021 Jul 28:S1097-2765(21)00587-6. PMID: 34358447
B cells in multiple sclerosis - from targeted depletion to immune reconstitution therapies. Cencioni MT, Mattoscio M, Magliozzi R, Bar-Or A, Muraro PA. Nat Rev Neurol. 2021 Jul;17(7):399-414. PMID: 34075251
ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements. Bermudez CA, Crespo MM, Shlobin OA, Cantu E, Mazurek JA, Levine D, Gutsche J, Kanwar M, Dellgren G, Bush EL, Heresi GA, Cypel M, Hadler R, Kolatis N, Franco V, Benvenuto L, Mooney J, Pipeling M, King C, Mannem H, Raman S, Knoop C, Douglas A, Mercier O. J Heart Lung Transplant. 2021 Jul 29:S1053-2498(21)02435-9. PMID: 34404570
Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition. Liu X, Verma A, Garcia G, Ramage H, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. medRxiv. 2021 Jul 21:2021.02.17.21251933. PMID: 33655282 PMCID: PMC7924307
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit. Hall MD, Anderson JM, Anderson A, Baker D, Bradner J, Brimacombe KR, Campbell EA, Corbett KS, Carter K, Cherry S, Chiang L, Cihlar T, de Wit E, Denison M, Disney M, Fletcher CV, Ford-Scheimer SL, Götte M, Grossman AC, Hayden FG, Hazuda DJ, Lanteri CA, Marston H, Mesecar AD, Moore S, Nwankwo JO, O'Rear J, Painter G, Singh Saikatendu K, Schiffer CA, Sheahan TP, Shi PY, Smyth HD, Sofia MJ, Weetall M, Weller SK, Whitley R, Fauci AS, Austin CP, Collins FS, Conley AJ, Davis MI. J Infect Dis. 2021 Jul 15;224(Supplement_1):S1-S21. PMID: 34111271 PMCID: PMC8280938
Morphologically malignant nodular fasciitis with CALD1-USP6 fusion. Papke DJ Jr, Oliveira AM, Chou MM, Fletcher CDM. Virchows Arch. 2021 Jul 2. doi: 10.1007/s00428-021-03149-8. PMID: 34213575
Plasma Nucleosomes Are Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome. Yehya N, Fazelinia H, Lawrence GG, Spruce LA, Mai MV, Worthen GS, Christie JD. Crit Care Med. 2021 Jul 1;49(7):1149-1158. PMID: 33729723
Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients. Shah P, Lowery E, Chaparro C, Visner G, Hempstead SE, Abraham J, Bhakta Z, Carroll M, Christon L, Danziger-Isakov L, Diamond JM, Lease E, Leonard J, Litvin M, Poole R, Vlahos F, Werchan C, Murray MA, Tallarico E, Faro A, Pilewski JM, Hachem RR. J Heart Lung Transplant. 2021 Jul;40(7):539-556. PMID: 34103223
Auditory and olfactory findings in patients with USH2A-related retinal degeneration-Findings at baseline from the rate of progression in USH2A-related retinal degeneration natural history study (RUSH2A). Iannaccone A, Brewer CC, Cheng P, Duncan JL, Maguire MG, Audo I, Ayala AR, Bernstein PS, Bidelman GM, Cheetham JK, Doty RL, Durham TA, Hufnagel RB, Myers MH, Stingl K, Zein WM; Foundation Fighting Blindness Consortium Investigator Group. Am J Med Genet A. 2021 Jul 30. PMID: 34331386
Effect of Esketamine Nasal Spray on Olfactory Function and Nasal Tolerability in Patients with Treatment-Resistant Depression: Results from Four Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Studies. Doty RL, Popova V, Wylie C, Fedgchin M, Daly E, Janik A, Ochs-Ross R, Lane R, Lim P, Cooper K, Melkote R, Jamieson C, Singh J, Drevets WC. CNS Drugs. 2021 Jul;35(7):781-794. PMID: 34235612 PMCID: PMC8310483

June 2021

Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV. Giron LB, Palmer CS, Liu Q, Yin X, Papasavvas E, Sharaf R, Etemad B, Damra M, Goldman AR, Tang HY, Johnston R, Mounzer K, Kostman JR, Tebas P, Landay A, Montaner LJ, Jacobson JM, Li JZ, Abdel-Mohsen M. Nat Commun. 2021 Jun 29;12(1):3922. PMID: 34188039
Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients. Giron LB, Dweep H, Yin X, Wang H, Damra M, Goldman AR, Gorman N, Palmer CS, Tang HY, Shaikh MW, Forsyth CB, Balk RA, Zilberstein NF, Liu Q, Kossenkov A, Keshavarzian A, Landay A, Abdel-Mohsen M. Front Immunol. 2021 Jun 9;12:686240. eCollection 2021. PMID: 34177935
Erratum for Adeniji et al., "COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions". Adeniji OS, Giron LB, Purwar M, Zilberstein NF, Kulkarni AJ, Shaikh MW, Balk RA, Moy JN, Forsyth CB, Liu Q, Dweep H, Kossenkov A, Weiner DB, Keshavarzian A, Landay A, Abdel-Mohsen M. mBio. 2021 Jun 8:e0124421. Online ahead of print. PMID: 34098736
Determinants of kidney transplant candidates' decision to accept organ donor intervention transplants and participate in post-transplant research: A conjoint analysis. Gordon EJ, Abt P, Lee J, Knopf E, Phillips C, Bermudez F, Krishnamurthi L, Karaca HS, Veatch R, Knight R, Conway PT, Dunn S, Reese PP. Clin Transplant. 2021 Jun;35(6):e14316. Epub 2021 May 2. PMID: 33844367
18F-Sodium Fluoride PET as a Diagnostic Modality for Metabolic, Autoimmune, and Osteogenic Bone Disorders: Cellular Mechanisms and Clinical Applications. Park PSU, Raynor WY, Sun Y, Werner TJ, Rajapakse CS, Alavi A. Int J Mol Sci. 2021 Jun 17;22(12):6504. PMID: 34204387
Expression of MRGPRX2 in skin mast cells of patients with maculopapular cutaneous mastocytosis. Deepak V, Komarow HD, Alblaihess AA, Carter MC, Metcalfe DD, Ali H. J Allergy Clin Immunol Pract. 2021 Jun 25:S2213-2198(21)00697-8. Online ahead of print. PMID: 34182161
Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis. Church ME, Ceja G, McGeehan M, Miller MC, Farias P, Sánchez MD, Swain GP, Assenmacher CA, Stopa EG, Vite CH, Bar-Or A, Alvarez JI. J Immunol. 2021 Jun 23:ji2000514. Online ahead of print. PMID: 34162727
The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients. Pyfrom S, Paneru B, Knox JJ, Cancro MP, Posso S, Buckner JH, Anguera MC. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2024624118. PMID: 34103397 PMCID: PMC8214693
Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances. Bar-Or A, Li R. Lancet Neurol. 2021 Jun;20(6):470-483. doi: 10.1016/S1474-4422(21)00063-6. Epub 2021 Apr 27. PMID: 33930317 Review.
TNF blockade uncouples toxicity from antitumor efficacy induced with CD40 chemoimmunotherapy. Stone ML, Lee J, Herrera VM, Graham K, Lee JW, Huffman A, Coho H, Tooker E, Myers MI, Giannone M, Li Y, Buckingham TH, Long KB, Beatty GL. JCI Insight. 2021 Jun 8:146314. Online ahead of print. PMID: 34101617
Serum Amyloid A Proteins and Their Impact on Metastasis and Immune Biology in Cancer. Lee J, Beatty GL. Cancers (Basel). 2021 Jun 25;13(13):3179. PMID: 34202272 Review.
Transcriptional regulation of T cell metabolism and metabolic control of T cell gene expression. Veliz K, Beier UH. Curr Opin Genet Dev. 2021 Jun 26;70:83-88. Online ahead of print. PMID: 34186442 Review.
Remodeling of the maternal gut microbiome during pregnancy is shaped by parity. Berry ASF, Pierdon MK, Misic AM, Sullivan MC, O'Brien K, Chen Y, Murray SJ, Ramharack LA, Baldassano RN, Parsons TD, Beiting DP. Microbiome. 2021 Jun 27;9(1):146. PMID: 34176489 PMCID: PMC8237508
Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs. Gui J, Zahedi F, Ortiz A, Cho C, Katlinski KV, Alicea-Torres K, Li J, Todd L, Zhang H, Beiting DP, Sander C, Kirkwood JM, Snow BE, Wakeham AC, Mak TW, Diehl JA, Koumenis C, Ryeom SW, Stanger BZ, Puré E, Gabrilovich DI, Fuchs SY. Nat Cancer. 2020 Jun;1(6):603-619. Epub 2020 May 25. PMID: 34124690 PMCID: PMC8194112
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML. Riedel SS, Lu C, Xie HM, Nestler K, Vermunt MW, Lenard A, Bennett L, Speck NA, Hanamura I, Lessard JA, Blobel GA, Garcia BA, Bernt KM. Mol Cell. 2021 Jun 3;81(11):2332-2348.e9. Epub 2021 May 10. PMID: 33974912
Integrative Multi-Omics Reveals Serum Markers of Tuberculosis in Advanced HIV. Krishnan S, Queiroz ATL, Gupta A, Gupte N, Bisson GP, Kumwenda J, Naidoo K, Mohapi L, Mave V, Mngqibisa R, Lama JR, Hosseinipour MC, Andrade BB, Karakousis PC. Front Immunol. 2021 Jun 8;12:676980. eCollection 2021. PMID: 34168648 PMCID: PMC8217878
Hematopoietic Stem Cell Transplantation Successfully Treats CD40LG Duplication. Sun D, Le Coz C, Bunin N, Romberg N. J Clin Immunol. 2021 Jun 22. . Online ahead of print. PMID: 34159508
The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients. Pyfrom S, Paneru B, Knox JJ, Cancro MP, Posso S, Buckner JH, Anguera MC. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2024624118. PMID: 34103397
A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury. Li C, Patel K, Tu Z, Yang X, Kulik L, Alawieh A, Allen P, Cheng Q, Wallace C, Kilkenny J, Kwon J, Gibney B, Cantu E, Sharma A, Pipkin M, Machuca T, Emtiazjoo A, Goddard M, Holers VM, Nadig S, Christie J, Tomlinson S, Atkinson C. Am J Transplant. 2021 Jun;21(6):2067-2078. Epub 2021 Feb 26. PMID: 33210808 PMCID: PMC8246004
Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure. Daghlas I, Karhunen V, Ray D, Zuber V, Burgess S, Tsao PS, Lynch JA, Lee KM, Voight BF, Chang KM, Baker EH, Damrauer SM, Howson JMM, Vujkovic M, Gill D. J Am Heart Assoc. 2021 Jun 29:e020331. Online ahead of print. PMID: 34184541
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease. Levin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM; VA Million Veteran Program. Circulation. 2021 Jun 18. Online ahead of print. PMID: 34139859
Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes. Khandelwal S, Barnes A, Rauova L, Sarkar A, Rux AH, Yarovoi SV, Zaitsev S, Lambris JD, Myoung SS, Johnson A, Lee GM, Duarte M, Poncz M, Arepally GM, Cines DB. Blood. 2021 Jun 29:blood.2020009487. Online ahead of print. PMID: 34189574
COVID-19 vaccination and immune thrombocytopenia. Pishko AM, Bussel JB, Cines DB. Nat Med. 2021 Jun 9. Online ahead of print. PMID: 34108715
SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. Cines DB, Bussel JB. N Engl J Med. 2021 Jun 10;384(23):2254-2256. Epub 2021 Apr 16. PMID: 33861524 PMCID: PMC8063912
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons. Sherrill-Mix S, Hwang Y, Roche AM, Glascock A, Weiss SR, Li Y, Haddad L, Deraska P, Monahan C, Kromer A, Graham-Wooten J, Taylor LJ, Abella BS, Ganguly A, Collman RG, Van Duyne GD, Bushman FD. Genome Biol. 2021 Jun 3;22(1):169. PMID: 34082799 PMCID: PMC8173101
Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel. Bouché M, Dong YC, Sheikh S, Taing K, Saxena D, Hsu JC, Chen MH, Salinas RD, Song H, Burdick JA, Dorsey J, Cormode DP. ACS Biomater Sci Eng. 2021 Jun 23. Online ahead of print. PMID: 34160196
Positive Long-Term Effects of Third Molar Extraction on Taste Function. Kim D, Doty RL. Chem Senses. 2021 Jun 23:bjab032. Online ahead of print. PMID: 34161573
Biopsy of the olfactory epithelium from the superior nasal septum: is it possible to obtain neurons without damaging olfaction? Garcia ECD, Luz LA, Anzolin LK, Barbosa da Silva JL, Doty RL, Pinna FR, Voegels RL, Fornazieri MA. Braz J Otorhinolaryngol. 2021 Jun 5:S1808-8694(21)00093-8. Online ahead of print. PMID: 34144902
Effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naïve adults living with HIV. Spitsin S, Pappa V, Kinder A, Evans DL, Rappaport J, Douglas SD. Medicine (Baltimore). 2021 Jun 11;100(23):e25313. PMID: 34114978 PMCID: PMC8202663
Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation. Toulmin SA, Bhadiadra C, Paris AJ, Lin JH, Katzen J, Basil MC, Morrisey EE, Worthen GS, Eisenlohr LC. Nat Commun. 2021 Jun 28;12(1):3993. PMID: 34183650
Urban residential tree canopy and perceived stress among pregnant women. Nguemeni Tiako MJ, South E, Shannon MM, McCarthy C, Meisel ZF, Elovitz MA, Burris HH. Environ Res. 2021 Jun 30:111620. Online ahead of print. PMID: 34216611
Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses. Uyanik B, Goloudina AR, Akbarali A, Grigorash BB, Petukhov AV, Singhal S, Eruslanov E, Chaloyard J, Lagorgette L, Hadi T, Baidyuk EV, Sakai H, Tessarollo L, Ryffel B, Mazur SJ, Lirussi F, Garrido C, Appella E, Demidov ON. Nat Commun. 2021 Jun 15;12(1):3622. PMID: 34131120 PMCID: PMC8206133
Budesonide Oral Suspension Improves Outcomes in Patients With Eosinophilic Esophagitis: Results from a Phase 3 Trial. Hirano I, Collins MH, Katzka DA, Mukkada VA, Falk GW, Morey R, Desai NK, Lan L, Williams J, Dellon ES. Clin Gastroenterol Hepatol. 2021 Jun 29:S1542-3565(21)00697-2. Online ahead of print. PMID: 34214677
Long-Term Treatment of Eosinophilic Esophagitis with Budesonide Oral Suspension. Dellon ES, Collins MH, Katzka DA, Mukkada VA, Falk GW, Morey R, Goodwin B, Eisner JD, Lan L, Desai NK, Williams J, Hirano I; ORBIT2/SHP621-302 investigators. Clin Gastroenterol Hepatol. 2021 Jun 25:S1542-3565(21)00684-4. Online ahead of print. PMID: 34182150
Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Ali Nabavizadeh S, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y. Nat Commun. 2021 Jun 8;12(1):3424. PMID: 34103524 PMCID: PMC8187342
A Systematic Review of the Potential Implication of Infectious Agents in Myasthenia Gravis. Leopardi V, Chang YM, Pham A, Luo J, Garden OA. Front Neurol. 2021 Jun 14;12:618021. eCollection 2021. PMID: 34194378 PMCID: PMC8236805
Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor. Uberoi A, Bartow-McKenney C, Zheng Q, Flowers L, Campbell A, Knight SAB, Chan N, Wei M, Lovins V, Bugayev J, Horwinski J, Bradley C, Meyer J, Crumrine D, Sutter CH, Elias P, Mauldin E, Sutter TR, Grice EA. Cell Host Microbe. 2021 Jun 29:S1931-3128(21)00239-0. Online ahead of print. PMID: 34214492
Early detection of SARS-CoV-2 and other infections in solid organ transplant recipients and household members using wearable devices. Keating BJ, Mukhtar EH, Elftmann ED, Eweje FR, Gao H, Ibrahim LI, Kathawate RG, Lee AC, Li EH, Moore KA, Nair N, Chaluvadi V, Reason J, Zanoni F, Honkala AT, Al-Ali AK, Abdullah Alrubaish F, Ahmad Al-Mozaini M, Al-Muhanna FA, Al-Romaih K, Goldfarb SB, Kellogg R, Kiryluk K, Kizilbash SJ, Kohut TJ, Kumar J, O'Connor MJ, Rand EB, Redfield RR, Rolnik B, Rossano J, Sanchez PG, Alavi A, Bahmani A, Bogu GK, Brooks AW, Metwally AA, Mishra T, Marks SD, Montgomery RA, Fishman JA, Amaral S, Jacobson PA, Wang M, Snyder MP. Transpl Int. 2021 Jun;34(6):1019-1031. Epub 2021 May 5. PMID: 33735480 PMCID: PMC8250335
Multivariable Dependence of Acoustic Contrast of Fluorocarbon and Xenon Microbubbles under Flow. Chattaraj R, Hammer DA, Lee D, Sehgal CM. Ultrasound Med Biol. 2021 Jun 7:S0301-5629(21)00204-0. Online ahead of print. PMID: 34112553
SARS-CoV-2 Seropositivity and Seroconversion in Patients Undergoing Active Cancer-Directed Therapy. Sun L, Surya S, Goodman NG, Le AN, Kelly G, Owoyemi O, Desai H, Zheng C, DeLuca S, Good ML, Hussain J, Jeffries SD, Kry YR, Kugler EM, Mansour M, Ndicu J, Osei-Akoto A, Prior T, Pundock SL, Varughese LA, Weaver J, Doucette A, Dudek S, Verma SS, Gouma S, Weirick ME, McAllister CM, Bange E, Gabriel P, Ritchie M, Rader DJ, Vonderheide RH, Schuchter LM, Verma A, Maillard I, Mamtani R, Hensley SE, Gross R, Wileyto EP, Huang AC, Maxwell KN, DeMichele A. JCO Oncol Pract. 2021 Jun 16:OP2100113. Online ahead of print. PMID: 34133219
An Egg-Derived Sulfated N-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines. Guthmiller JJ, Utset HA, Henry C, Li L, Zheng NY, Sun W, Costa Vieira M, Zost S, Huang M, Hensley SE, Cobey S, Palese P, Wilson PC. mBio. 2021 Jun 15:e0083821. Online ahead of print. PMID: 34126773
Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia. Myers RM, Li Y, Barz Leahy A, Barrett DM, Teachey DT, Callahan C, Fasano CC, Rheingold SR, DiNofia A, Wray L, Aplenc R, Baniewicz D, Liu H, Shaw PA, Pequignot E, Getz KD, Brogdon JL, Fesnak AD, Siegel DL, Davis MM, Bartoszek C, Lacey SF, Hexner EO, Chew A, Wertheim GB, Levine BL, June CH, Grupp SA, Maude SL. J Clin Oncol. 2021 Jun 22:JCO2003458. Online ahead of print. PMID: 34156874
SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms. Vazquez C, Swanson SE, Negatu SG, Dittmar M, Miller J, Ramage HR, Cherry S, Jurado KA. PLoS One. 2021 Jun 24;16(6):e0253089. eCollection 2021. PMID: 34166398
Cerebral Cavernous Malformation: From Mechanism to Therapy. Snellings DA, Hong CC, Ren AA, Lopez-Ramirez MA, Girard R, Srinath A, Marchuk DA, Ginsberg MH, Awad IA, Kahn ML. Circ Res. 2021 Jun 25;129(1):195-215. Epub 2021 Jun 24. PMID: 34166073
Maintenance of the human memory T cell repertoire by subset and tissue site. Miron M, Meng W, Rosenfeld AM, Dvorkin S, Poon MML, Lam N, Kumar BV, Louzoun Y, Luning Prak ET, Farber DL. Genome Med. 2021 Jun 14;13(1):100. PMID: 34127056 PMCID: PMC8204429
MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis. Slaff B, Radens CM, Jewell P, Jha A, Lahens NF, Grant GR, Thomas-Tikhonenko A, Lynch KW, Barash Y. Nat Commun. 2021 Jun 7;12(1):3353. PMID: 34099673 PMCID: PMC8184769
Deep learning to detect acute respiratory distress syndrome on chest radiographs: a retrospective study with external validation. Sjoding MW, Taylor D, Motyka J, Lee E, Co I, Claar D, McSparron JI, Ansari S, Kerlin MP, Reilly JP, Shashaty MGS, Anderson BJ, Jones TK, Drebin HM, Ittner CAG, Meyer NJ, Iwashyna TJ, Ward KR, Gillies CE. Lancet Digit Health. 2021 Jun;3(6):e340-e348. Epub 2021 Apr 20. PMID: 33893070 PMCID: PMC8182690
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV. Giron LB, Palmer CS, Liu Q, Yin X, Papasavvas E, Sharaf R, Etemad B, Damra M, Goldman AR, Tang HY, Johnston R, Mounzer K, Kostman JR, Tebas P, Landay A, Montaner LJ, Jacobson JM, Li JZ, Abdel-Mohsen M. Nat Commun. 2021 Jun 29;12(1):3922. PMID: 34188039
Myeloablative versus Reduced-Intensity Conditioning for Hematopoietic Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndromes-Long-Term Follow-Up of the BMT CTN 0901 Clinical Trial. Scott BL, Pasquini MC, Fei M, Fraser R, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick E, Fernandez HF, Soiffer RJ, Alyea E, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Hourigan CS, Gui G, Mendizabal A, Horowitz MM, Deeg HJ, Horwitz ME. Transplant Cell Ther. 2021 Jun;27(6):483.e1-483.e6. Epub 2021 Feb 26. PMID: 33775615 PMCID: PMC8217373
Do Corticosteroid Injections for the Treatment of Pain Influence the Efficacy of Adenovirus Vector-Based COVID-19 Vaccines? Lee H, Punt JA, Patel J, Stojanovic MP, Duszynski B, McCormick ZL; Spine Intervention Society’s Patient Safety Committee. Pain Med. 2021 Jun 4;22(6):1441-1464. PMID: 33839780 PMCID: PMC8083288
Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism. Abbey D, Conlon D, Rainville C, Elwyn S, Quiroz-Figueroa K, Billheimer J, Schultz DC, Hand NJ, Cherry S, Rader DJ. Clin Transl Sci. 2021 Jun 22. Online ahead of print. PMID: 34156146
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.Veturi Y, Lucas A, Bradford Y, Hui D, Dudek S, Theusch E, Verma A, Miller JE, Kullo I, Hakonarson H, Sleiman P, Schaid D, Stein CM, Edwards DRV, Feng Q, Wei WQ, Medina MW, Krauss RM, Hoffmann TJ, Risch N, Voight BF, Rader DJ, Ritchie MD. Nat Genet. 2021 Jun 17. Online ahead of print. PMID: 34140684
Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes. Khandelwal S, Barnes A, Rauova L, Sarkar A, Rux AH, Yarovoi SV, Zaitsev S, Lambris JD, Myoung SS, Johnson A, Lee GM, Duarte M, Poncz M, Arepally GM, Cines DB. Blood. 2021 Jun 29:blood.2020009487. Online ahead of print. PMID: 34189574
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML. Riedel SS, Lu C, Xie HM, Nestler K, Vermunt MW, Lenard A, Bennett L, Speck NA, Hanamura I, Lessard JA, Blobel GA, Garcia BA, Bernt KM. Mol Cell. 2021 Jun 3;81(11):2332-2348.e9. Epub 2021 May 10. PMID: 33974912
The Risk of Allergic Reaction to SARS-CoV-2 Vaccines and Recommended Evaluation and Management: A Systematic Review, Meta-analysis, GRADE Assessment, and International Consensus Approach. Greenhawt M, Abrams EM, Shaker M, Chu DK, Kahn D, Akin C, Alqurashi W, Arkwright P, Baldwin JL, Ben-Shoshan M, Bernstein J, Bingeman T, Blumchen K, Byrne A, Bognanni A, Campbell D, Campbell R, Chagla Z, Chan ES, Chan J, Comberiatti P, Dribin TE, Ellis AK, Fleischer DM, Fox A, Frischmeyer-Guerrerio PA, Gagnon R, Grayson MH, Horner CC, Hourihane J, Katelaris CH, Kim H, Kelso JM, Lang D, Ledford D, Levin M, Lieberman J, Loh R, Mack D, Mazer B, Mosnaim G, Munblit D, Mustafa SS, Nanda A, Oppenheimer J, Perrett KP, Ramsey A, Rank M, Robertson K, Shiek J, Spergel JM, Stukus D, Tang ML, Tracy JM, Turner PJ, Whalen-Browne A, Wallace D, Wang J, Wasserman S, Witty JK, Worm M, Vander Leek TK, Golden DB. J Allergy Clin Immunol Pract. 2021 Jun 18:S2213-2198(21)00671-1. Online ahead of print. PMID: 34153517 PMCID: PMC8248554
Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors. Arehart CH, Daya M, Campbell M, Boorgula MP, Rafaels N, Chavan S, David G, Hanifin J, Slifka MK, Gallo RL, Hata T, Schneider LC, Paller AS, Ong PY, Spergel JM, Guttman-Yassky E, Leung DYM, Beck LA, Gignoux CR, Mathias RA, Barnes KC. J Allergy Clin Immunol. 2021 Jun 7:S0091-6749(21)00895-2. Online ahead of print. PMID: 34111454
Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency. Magg T, Okano T, Koenig LM, Boehmer DFR, Schwartz SL, Inoue K, Heimall J, Licciardi F, Ley-Zaporozhan J, Ferdman RM, Caballero-Oteyza A, Park EN, Calderon BM, Dey D, Kanegane H, Cho K, Montin D, Reiter K, Griese M, Albert MH, Rohlfs M, Gray P, Walz C, Conn GL, Sullivan KE, Klein C, Morio T, Hauck F. Sci Immunol. 2021 Jun 18;6(60):eabf9564. PMID: 34145065
Distinct immune trajectories in patients with chromosome 22q11.2 deletion syndrome and immune-mediated diseases. Crowley TB, Campbell IM, Liebling EJ, Lambert MP, Levitt Katz LE, Heimall J, Bailey A, McGinn DE, McDonald McGinn DM, Sullivan KE. J Allergy Clin Immunol. 2021 Jun 16:S0091-6749(21)00939-8. Online ahead of print. PMID: 34144109
Mucosal Invariant T cells are Diminished in Very Early-Onset Inflammatory Bowel Disease. Dou Y, Maurer K, Conrad M, Patel T, Shraim R, Sullivan KE, Kelsen J. J Pediatr Gastroenterol Nutr. 2021 Jun 7. Online ahead of print. PMID: 34117197
Therapeutic options for CTLA-4 Insufficiency. Egg D, Rump IC, Mitsuiki N, Rojas-Restrepo J, Maccari ME, Schwab C, Gabrysch A, Warnatz K, Goldacker S, Patiño V, Wolff D, Okada S, Hayakawa S, Shikama Y, Kanda K, Imai K, Sotomatsu M, Kuwashima M, Kamiya T, Morio T, Matsumoto K, Mori T, Yoshimoto Y, Dybedal I, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Lorenz HM, Sullivan KE, Heimall J, Moutschen M, Litzman J, Recher M, Albert MH, Hauck F, Seneviratne S, Schmid JP, Kolios A, Unglik G, Klemann C, Snapper S, Giulino-Roth L, Svaton M, Platt CD, Hambleton S, Neth O, Gosse G, Reinsch S, Holzinger D, Kim YJ, Bakhtiar S, Atschekzei F, Schmidt R, Sogkas G, Chandrakasan S, Rae W, Derfalvi B, Marquart HV, Ozen A, Kiykim A, Karakoc-Aydiner E, Králíčková P, de Bree G, Kiritsi D, Seidel MG, Kobbe R, Dantzer J, Alsina L, Armangue T, Lougaris V, Agyeman P, Nyström S, Buchbinder D, Arkwright PD, Grimbacher B. J Allergy Clin Immunol. 2021 Jun 7:S0091-6749(21)00891-5. Online ahead of print. PMID: 34111452
Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia. Li Y, Yang W, Devidas M, Winter SS, Kesserwan C, Yang W, Dunsmore KP, Smith C, Qian M, Zhao X, Zhang R, Gastier-Foster JM, Raetz EA, Carroll WL, Li C, Liu PP, Rabin KR, Sanda T, Mullighan CG, Nichols KE, Evans WE, Pui CH, Hunger SP, Teachey DT, Relling MV, Loh ML, Yang JJ. J Clin Invest. 2021 Jun 24:147898. Online ahead of print. PMID: 34166225
Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia. Myers RM, Li Y, Barz Leahy A, Barrett DM, Teachey DT, Callahan C, Fasano CC, Rheingold SR, DiNofia A, Wray L, Aplenc R, Baniewicz D, Liu H, Shaw PA, Pequignot E, Getz KD, Brogdon JL, Fesnak AD, Siegel DL, Davis MM, Bartoszek C, Lacey SF, Hexner EO, Chew A, Wertheim GB, Levine BL, June CH, Grupp SA, Maude SL. J Clin Oncol. 2021 Jun 22:JCO2003458. Online ahead of print. PMID: 34156874
Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection. Schultz DC, Johnson RM, Ayyanathan K, Miller J, Whig K, Kamalia B, Dittmar M, Weston S, Hammond HL, Dillen C, Castellana L, Lee JS, Li M, Lee E, Constant S, Ferrer M, Thaiss CA, Frieman MB, Cherry S. bioRxiv. 2021 Jun 24:2021.06.24.449811. Preprint. PMID: 34189531 PMCID: PMC8240684
Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts. Schulz L, Torres-Diz M, Cortés-López M, Hayer KE, Asnani M, Tasian SK, Barash Y, Sotillo E, Zarnack K, König J, Thomas-Tikhonenko A. Genome Biol. 2021 Jun 28;22(1):190. PMID: 34183059 PMCID: PMC8240250
Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling. Altshuler PJ, Schiazza AR, Luo L, Helmers MR, Chhay B, Han JJ, Hu R, Herbst DA, Tsourkas A, Cheng Z, Atluri P. Adv Ther (Weinh). 2021 Jun;4(6):2100036. Epub 2021 Apr 23. PMID: 34179348 PMCID: PMC8225225
Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis. Vukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N; GRADS Investigators. Eur Respir J. 2021 Jun 3:2002950. PMID: 34083402

May 2021

Prevalence of asthma in hospitalized and non-hospitalized children with COVID-19. Floyd GC, Dudley JW, Xiao R, Feudtner C, Taquechel K, Miller K, Henrickson SE, Hill DA, Kenyon CC. J Allergy Clin Immunol Pract. 2021 May;9(5):2077-2079.e2. doi: 10.1016/j.jaip.2021.02.038. PMID: 33676051
B-cell maturation antigen chimeric antigen receptor T-cell re-expansion in a patient with myeloma following salvage programmed cell death protein 1 inhibitor-based combination therapy. Bernabei L, Tian L, Garfall AL, Melenhorst JJ, Lacey SF, Stadtmauer EA, Vogl DT, Gonzalez VE, Plesa G, Young RM, Waxman A, Levine BL, June CH, Milone MC, Cohen AD. Br J Haematol. 2021 May;193(4):851-855. PMID: 33713436
IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity. Garcia de Mattos Barbosa M, Liu H, Huynh D, Shelley G, Keller ET, Emmer BT, Sherman EJ, Ginsburg D, Kennedy AA, Tai AW, Wobus CE, Mirabelli C, Lanigan TM, Samaniego M, Meng W, Rosenfeld AM, Luning Prak ET, Platt JL, Cascalho M. JCI Insight. 2021 Mar 26:147386. doi: 10.1172/jci.insight.147386. Online ahead of print. PMID: 33769311
ANGPTL3 Inhibition With Evinacumab Results in Faster Clearance of IDL and LDL apoB in Patients With Homozygous Familial Hypercholesterolemia. Reeskamp LF, Millar JS, Wu L, Jansen H, van Harskamp D, Schierbeek H, Gipe DA, Rader DJ, Dallinga-Thie GM, Hovingh GK, Cuchel M. Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1753-1759. Online ahead of print. PMID: 33691480
Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization. Chompunud Na Ayudhya C, Amponnawarat A, Ali H. Int J Mol Sci. 2021 May 18;22(10):5318. doi: 10.3390/ijms22105318. PMID: 34070125
Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease. Roy S, Chompunud Na Ayudhya C, Thapaliya M, Deepak V, Ali H. J Allergy Clin Immunol. 2021 May 4:S0091-6749(21)00721-1. doi: 10.1016/j.jaci.2021.03.049. Online ahead of print. PMID: 33957166
A n interdomain helix in IRE1α mediates the conformational change required for the sensor's activation. Ricci D, Tutton S, Marrocco I, Ying M, Blumenthal D, Eletto D, Vargas J, Boyle S, Fazelinia H, Qian L, Suresh K, Taylor D, Paton JC, Paton AW, Anthony Tang CH, Andrew Hu CC, Radhakrishnan R, Gidalevitz T, Argon Y. J Biol Chem. 2021 May 14:100781. doi: 10.1016/j.jbc.2021.100781. Online ahead of print. PMID: 34000298 PMCID: PMC8203841
Factor IX assay discrepancies in the setting of liver gene therapy using a hyperfunctional variant factor IX-Padua . Robinson MM, George LA, Carr ME, Samelson-Jones BJ, Arruda VR, Murphy JE, Rybin D, Rupon J, High KA, Tiefenbacher S. J Thromb Haemost. 2021 May;19(5):1212-1218. doi: 10.1111/jth.15281. Epub 2021 Mar 28. PMID: 33636038 PMCID: PMC8130854
Examining cognitive speed and accuracy dysfunction in youth and young adults with pediatric-onset multiple sclerosis using a computerized neurocognitive battery. Barlow-Krelina E, Fabri TL, O'Mahony J, Gur RC, Gur RE, De Somma E, Bolongaita L, Dunn CL, Bacchus M, Yeh EA, Marrie RA, Bar-Or A, Banwell BL, Till C. Neuropsychology. 2021 May;35(4):388-398. doi: 10.1037/neu0000729. PMID: 34043389
Author Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study.
Bar-Or A, Herman A, Stokmaier D. Neurology. 2021 May 4;96(18):870. doi: 10.1212/WNL.0000000000011868. PMID: 34032593 No abstract available.
Artificial intelligence extension of the OSCAR-IB criteria. Petzold A, Albrecht P, Balcer L, Bekkers E, Brandt AU, Calabresi PA, Deborah OG, Graves JS, Green A, Keane PA, Nij Bijvank JA, Sander JW, Paul F, Saidha S, Villoslada P, Wagner SK, Yeh EA; IMSVISUAL, ERN-EYE Consortium. Ann Clin Transl Neurol. 2021 May 19. doi: 10.1002/acn3.51320. Online ahead of print. PMID: 34008926 Review.
Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19). Anderson EM, Diorio C, Goodwin EC, McNerney KO, Weirick ME, Gouma S, Bolton MJ, Arevalo CP, Chase J, Hicks P, Manzoni TB, Baxter AE, Andrea KP, Burudpakdee C, Lee JH, Vella LA, Henrickson SE, Harris RM, Wherry EJ, Bates P, Bassiri H, Behrens EM, Teachey DT, Hensley SE. J Pediatric Infect Dis Soc. 2021 May 28;10(5):669-673. doi: 10.1093/jpids/piaa161. PMID: 33263756 PMCID: PMC7799010
Amelioration of Murine Macrophage Activation Syndrome by Monomethyl Fumarate in Both a Heme Oxygenase 1-Dependent and Heme Oxygenase 1-Independent Manner. Biswas C, Chu N, Burn TN, Kreiger PA, Behrens EM. Arthritis Rheumatol. 2021 May;73(5):885-895. doi: 10.1002/art.41591. Epub 2021 Mar 25. PMID: 33191652 PMCID: PMC8084959
Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies. Lu Z, Ortiz A, Verginadis II, Peck AR, Zahedi F, Cho C, Yu P, DeRita RM, Zhang H, Kubanoff R, Sun Y, Yaspan AT, Krespan E, Beiting DP, Radaelli E, Ryeom SW, Diehl JA, Rui H, Koumenis C, Fuchs SY. J Clin Invest. 2021 May 17;131(10):e144225. doi: 10.1172/JCI144225. PMID: 33998600 PMCID: PMC8121529
Inhibition of Gamma-secretase activity without interfering in Notch signaling decreases inflammatory response in patients with cutaneous leishmaniasis. Nascimento MT, Franca M, Carvalho AM, Amorim C, Peixoto F, Beiting D, Scott P, Carvalho EM, Carvalho LP. Emerg Microbes Infect. 2021 May 19:1-20. doi: 10.1080/22221751.2021.1932608. Online ahead of print. PMID: 34009107
Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells. McLane LM, Ngiow SF, Chen Z, Attanasio J, Manne S, Ruthel G, Wu JE, Staupe RP, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Freedman BD, Betts MR, Wherry EJ. Cell Rep. 2021 May 11;35(6):109120. doi: 10.1016/j.celrep.2021.109120. PMID: 33979613 PMCID: PMC8195461
Engineering three-dimensional genome folding. Zhang D, Lam J, Blobel GA. Nat Genet. 2021 May;53(5):602-611. doi: 10.1038/s41588-021-00860-9. Epub 2021 May 6. PMID: 33958782 Review.
Remodeling of the Posterior Cerebral Artery P1-Segment after Pipeline Flow Diverter Treatment of Posterior Communicating Artery Aneurysms . Litao MS, Burkhardt JK, Tanweer O, Raz E, Huang P, Becske T, Shapiro M, Riina H, Nelson PK. Neurol Int. 2021 May 7;13(2):195-201. doi: 10.3390/neurolint13020020. PMID: 34066972
Postmarket American Experience With Woven EndoBridge Device: Adjudicated Multicenter Case Series. Cherian J, Chen SR, Puri A, Vakharia K, Levy E, Eshraghi S, Howard BM, Tong FC, Cawley CM, Gross B, Alexander MD, Grandhi R, Srinivasan VM, Burkhardt JK, Johnson JN, Kan P. Neurosurgery. 2021 May 14:nyab158. doi: 10.1093/neuros/nyab158. Online ahead of print. PMID: 33989398
Flared non-flow diverting ends of the FRED flow diverter for cerebral aneurysms facilitate device anchoring at the arterial bifurcation. Burkhardt JK, McGuire LS, Griessenauer CJ. Neuroradiol J. 2021 May 4:19714009211013508. doi: 10.1177/19714009211013508. Online ahead of print. PMID: 33942661
Peel Learning for Pathway-Related Outcome Prediction. Li Y, Wang F, Yan M, Cantu E, Yang FN, Rao H, Feng R. Bioinformatics. 2021 May 27:btab402. doi: 10.1093/bioinformatics/btab402. Online ahead of print. PMID: 34042937
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Du M, Garcia JGN, Christie JD, Xin J, Cai G, Meyer NJ, Zhu Z, Yuan Q, Zhang Z, Su L, Shen S, Dong X, Li H, Hutchinson JN, Tejera P, Lin X, Wang M, Chen F, Christiani DC. Intensive Care Med. 2021 May 25:1-11. doi: 10.1007/s00134-021-06410-5. Online ahead of print. PMID: 34032881
The Supportive Care Needs of Primary Caregivers of Lung Transplant Candidates. Pawlow PC, Blumenthal NP, Christie JD, Matura LA, Aryal S, Ersek M. J Pain Symptom Manage. 2021 May 13:S0885-3924(21)00330-4. doi: 10.1016/j.jpainsymman.2021.05.004. Online ahead of print. PMID: 33992758
Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program. Song RJ, Ho YL, Schubert P, Park Y, Posner D, Lord EM, Costa L, Gerlovin H, Kurgansky KE, Anglin-Foote T, DuVall S, Huffman JE, Pyarajan S, Beckham JC, Chang KM, Liao KP, Djousse L, Gagnon DR, Whitbourne SB, Ramoni R, Muralidhar S, Tsao PS, O'Donnell CJ, Gaziano JM, Casas JP, Cho K; VA Million Veteran Program COVID-19 Science Initiative. PLoS One. 2021 May 13;16(5):e0251651. doi: 10.1371/journal.pone.0251651. eCollection 2021. PMID: 33984066 PMCID: PMC8118298
Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns. Gargano D, Appanna R, Santonicola A, De Bartolomeis F, Stellato C, Cianferoni A, Casolaro V, Iovino P. Nutrients. 2021 May 13;13(5):1638. doi: 10.3390/nu13051638. PMID: 34068047 PMCID: PMC8152468
Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus. Ma C, Schoepfer AM, Safroneeva E; COREOS Collaborators. Gastroenterology. 2021 May 19:S0016-5085(21)03020-1. doi: 10.1053/j.gastro.2021.04.080. Online ahead of print. PMID: 34022180
Food protein-induced enterocolitis syndrome epidemiology. Cianferoni A. Ann Allergy Asthma Immunol. 2021 May;126(5):469-477. doi: 10.1016/j.anai.2021.02.006. Epub 2021 Feb 16. PMID: 33607250
Alpha-defensins: risk factor for thrombosis in COVID-19 infection. Abdeen S, Bdeir K, Abu-Fanne R, Maraga E, Higazi M, Khurram N, Feldman M, Deshpande C, Litzky LA, Heyman SN, Montone KT, Cines DB, Higazi AA. Br J Haematol. 2021 May 30. doi: 10.1111/bjh.17503. Online ahead of print. PMID: 34053084
Precision targeting of the plasminogen activator inhibitor-1 mechanism increases efficacy of fibrinolytic therapy in empyema. Florova G, Girard RA, Azghani AO, Sarva K, Buchanan A, Karandashova S, DeVera CJ, Morris D, Chamiso M, Koenig K, Cines DB, Idell S, Komissarov AA. Physiol Rep. 2021 May;9(9):e14861. doi: 10.14814/phy2.14861. PMID: 33991465
An integrated self-powered 3D printed sample concentrator for highly sensitive molecular detection of HIV in whole blood at the point of care. Kadimisetty K , Yin K , Roche AM , Yi Y , Bushman FD , Collman RG , Gross R , Feng L , Liu C .Analyst. 2021 May 21;146(10):3234-3241. doi: 10.1039/d0an02482a. Epub 2021 Apr 8.PMID: 33999045
Rengasvirus, a Circular Replication-Associated Protein-Encoding Single-Stranded DNA Virus-Related Genome That Is a Common Contaminant in Metagenomic Data. Keeler EL, Taylor LJ, Abbas A, Collman RG, Bushman FD. Microbiol Resour Announc. 2021 May 6;10(18):e00273-21. doi: 10.1128/MRA.00273-21. PMID: 33958399 PMCID: PMC8103869
Detecting and Monitoring Hydrogels with Medical Imaging. Dong YC, Bouché M, Uman S, Burdick JA, Cormode DP. ACS Biomater Sci Eng. 2021 May 12. doi: 10.1021/acsbiomaterials.0c01547. Online ahead of print. PMID: 33979137
In Vivo Molecular K-Edge Imaging of Atherosclerotic Plaque Using Photon-counting CT. Si-Mohamed SA, Sigovan M, Hsu JC, Tatard-Leitman V, Chalabreysse L, Naha PC, Garrivier T, Dessouky R, Carnaru M, Boussel L, Cormode DP, Douek PC. Radiology. 2021 May 4:203968. doi: 10.1148/radiol.2021203968. Online ahead of print. PMID: 33944628
Preclinical development of plant-based oral immune modulatory therapy for haemophilia B . Srinivasan A, Herzog RW, Khan I, Sherman A, Bertolini T, Wynn T, Daniell H. Plant Biotechnol J. 2021 May 5. doi: 10.1111/pbi.13608. Online ahead of print. PMID: 33949086
Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Cohen JB, Yang W, Li L, Zhang X, Zheng Z, Orlandi P, Bansal N, Deo R, Lash JP, Rahman M, He J, Shafi T, Chen J, Cohen DL, Matsushita K, Shlipak MG, Wolf M, Go AS, Feldman HI; CRIC Study Investigators. Am J Kidney Dis. 2021 May 27:S0272-6386(21)00629-6. doi: 10.1053/j.ajkd.2021.03.021. Online ahead of print. PMID: 34052355
The "Shocking" Reality of ICD Therapies. Deo R, Pothineni NVK. J Am Coll Cardiol. 2021 May 25;77(20):2463-2465. doi: 10.1016/j.jacc.2021.04.019. PMID: 34016258
Universal HbA1c screening and gestational diabetes: a comparison with clinical risk factors. Bender W, McCarthy C, Elovitz M, Parry S, Durnwald C. J Matern Fetal Neonatal Med. 2021 May 27:1-7. doi: 10.1080/14767058.2021.1914578. Online ahead of print. PMID: 34044736
Adrenalitis and anasarca in idiopathic multicentric Castleman's disease. Chen LYC, Skinnider BF, Wilson D, Fajgenbaum DC. Lancet. 2021 May 8;397(10286):1749. doi: 10.1016/S0140-6736(21)00674-7. PMID: 33965090
Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis. Safroneeva E, Pan Z, King E, Martin LJ, Collins MH, Yang GY, Capocelli KE, Arva NC, Abonia JP, Atkins D, Bonis PA, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Leung J, Menard-Katcher PA, Mukkada VA, Schoepfer AM, Spergel JM, Wershil BK, Rothenberg ME, Aceves SS, Furuta GT; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Clin Gastroenterol Hepatol. 2021 May 29:S1542-3565(21)00588-7. doi: 10.1016/j.cgh.2021.05.049. Online ahead of print. PMID: 34062314
Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus. Ma C, Schoepfer AM, Safroneeva E; COREOS Collaborators. Gastroenterology. 2021 May 19:S0016-5085(21)03020-1. doi: 10.1053/j.gastro.2021.04.080. Online ahead of print. PMID: 34022180
Dichotomous and stable gamma delta T-cell number and function in healthy individuals. Ou L, Wang H, Liu Q, Zhang J, Lu H, Luo L, Shi C, Lin S, Dong L, Guo Y, Huang L, Zhu J, Yin X, Huang AC, Karakousis G, Schuchter L, Amaravadi R, Zheng C, Fan Y, Guo W, Xu X. J Immunother Cancer. 2021 May;9(5):e002274. doi: 10.1136/jitc-2020-002274. PMID: 34011536 PMCID: PMC8137237
Microbial Sharing between Pediatric Patients and Therapy Dogs during Hospital Animal-Assisted Intervention Programs. Dalton KR, Ruble K, Redding LE, Morris DO, Mueller NT, Thorpe RJ Jr, Agnew J, Carroll KC, Planet PJ, Rubenstein RC, Chen AR, Grice EA, Davis MF. Microorganisms. 2021 May 13;9(5):1054. doi: 10.3390/microorganisms9051054. PMID: 34068292 PMCID: PMC8153335
Insights into the skin microbiome of sickle cell disease leg ulcers. Byeon J, Blizinsky KD, Persaud A, Findley K, Lee JJ, Buscetta AJ, You S, Bittinger K, Minniti CP, Bonham VL, Grice EA. Wound Repair Regen. 2021 May 8. doi: 10.1111/wrr.12924. Online ahead of print. PMID: 33964094
A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen. Hoare A, Wang H, Meethil A, Abusleme L, Hong BY, Moutsopoulos NM, Marsh PD, Hajishengallis G, Diaz PI. ISME J. 2021 May;15(5):1490-1504. doi: 10.1038/s41396-020-00865-y. Epub 2020 Dec 28. PMID: 33372193 PMCID: PMC8115154
Successful Recanalization of Complete Bronchus Intermedius Stenosis after Lung Transplantation Guided by Intraprocedural Computed Tomographic Imaging. Ma KC, DiBardino DM, Haas AR. Ann Am Thorac Soc. 2021 May;18(5):889-892. doi: 10.1513/AnnalsATS.202006-633CC. PMID: 33929308
A new perspective on mesenchymal-immune interactions in adipose tissue. Jimenez MT, Michieletto MF, Henao-Mejia J. Trends Immunol. 2021 May;42(5):375-388. doi: 10.1016/j.it.2021.03.001. Epub 2021 Apr 10. PMID: 33849777 PMCID: PMC8202037
Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory. Morrison TA, Hudson WH, Chisolm DA, Kanno Y, Shih HY, Ahmed R, Henao-Mejia J, Hafner M, O'Shea JJ. Cold Spring Harb Perspect Biol. 2021 May 17:a037952. doi: 10.1101/cshperspect.a037952. Online ahead of print. PMID: 34001528
CD8⁺ T cells contribute to survival in patients with COVID-19 and hematologic cancer. Bange EM, Han NA, Wileyto P, Kim JY, Gouma S, Robinson J, Greenplate AR, Hwee MA, Porterfield F, Owoyemi O, Naik K, Zheng C, Galantino M, Weisman AR, Ittner CAG, Kugler EM, Baxter AE, Oniyide O, Agyekum RS, Dunn TG, Jones TK, Giannini HM, Weirick ME, McAllister CM, Babady NE, Kumar A, Widman AJ, DeWolf S, Boutemine SR, Roberts C, Budzik KR, Tollett S, Wright C, Perloff T, Sun L, Mathew D, Giles JR, Oldridge DA, Wu JE, Alanio C, Adamski S, Garfall AL, Vella LA, Kerr SJ, Cohen JV, Oyer RA, Massa R, Maillard IP, Maxwell KN, Reilly JP, Maslak PG, Vonderheide RH, Wolchok JD, Hensley SE, Wherry EJ, Meyer NJ, DeMichele AM, Vardhana SA, Mamtani R, Huang AC. Nat Med. 2021 May 20. doi: 10.1038/s41591-021-01386-7. Online ahead of print. PMID: 34017137
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults. Pan YG, Aiamkitsumrit B, Bartolo L, Wang Y, Lavery C, Marc A, Holec PV, Rappazzo CG, Eilola T, Gimotty PA, Hensley SE, Antia R, Zarnitsyna VI, Birnbaum ME, Su LF. Immunity. 2021 May 17:S1074-7613(21)00185-0. doi: 10.1016/j.immuni.2021.04.023. Online ahead of print. PMID: 34004140 PMCID: PMC8192456
Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19 . Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles J, Wu JE, Chen Z, Huang YJ, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ. bioRxiv. 2021 May 3:2021.05.01.442279. doi: 10.1101/2021.05.01.442279. Preprint. PMID: 33972943 PMCID: PMC8109205
One march, many paths: Insights into allergic march trajectories. Gabryszewski SJ, Hill DA. Ann Allergy Asthma Immunol. 2021 May 7:S1081-1206(21)00344-6. doi: 10.1016/j.anai.2021.04.036. Online ahead of print. PMID: 33971364
Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma. Durgin JS, Henderson F Jr, Nasrallah MP, Mohan S, Wang S, Lacey SF, Melenhorst JJ, Desai AS, Lee JYK, Maus MV, June CH, Brem S, O'Connor RS, Binder Z, O'Rourke DM. Front Oncol. 2021 May 7;11:669071. doi: 10.3389/fonc.2021.669071. eCollection 2021. PMID: 34026647 PMCID: PMC8138201
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells. Bai Z, Lundh S, Kim D, Woodhouse S, Barrett DM, Myers RM, Grupp SA, Maus MV, June CH, Camara PG, Melenhorst JJ, Fan R. J Immunother Cancer. 2021 May;9(5):e002328. doi: 10.1136/jitc-2020-002328. PMID: 34006631 PMCID: PMC8137188
Response to "Is Male Gender Associated with Increased Liver-related Mortality in Primary Biliary Cholangitis and Cirrhosis?". John BV, Deng Y, Martin P, Levy C, Taddei TH, Kaplan DE, Dahman B. Hepatology. 2021 May 22. doi: 10.1002/hep.31917. Online ahead of print. PMID: 34021933
Ursodeoxycholic Acid Response Is Associated With Reduced Mortality in Primary Biliary Cholangitis With Compensated Cirrhosis. John BV, Khakoo NS, Schwartz KB, Aitchenson G, Levy C, Dahman B, Deng Y, Goldberg DS, Martin P, Kaplan DE, Taddei TH. Am J Gastroenterol. 2021 May 13. doi: 10.14309/ajg.0000000000001280. Online ahead of print. PMID: 33989225
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. Pazoki R, Vujkovic M, Elliott J, Evangelou E, Gill D, Ghanbari M, van der Most PJ, Pinto RC, Wielscher M, Farlik M, Zuber V, de Knegt RJ, Snieder H, Uitterlinden AG; Lifelines Cohort Study, Lynch JA, Jiang X, Said S, Kaplan DE, Lee KM, Serper M, Carr RM, Tsao PS, Atkinson SR, Dehghan A, Tzoulaki I, Ikram MA, Herzig KH, Järvelin MR, Alizadeh BZ, O'Donnell CJ, Saleheen D, Voight BF, Chang KM, Thursz MR, Elliott P; VA Million Veteran Program. Nat Commun. 2021 May 10;12(1):2579. doi: 10.1038/s41467-021-22338-2. PMID: 33972514 PMCID: PMC8110798
Response to Lleo and Hirschfield. John BV, Dahman B, Taddei TH, Levy C, Kaplan DE. Hepatology. 2021 May 3. doi: 10.1002/hep.31876. Online ahead of print. PMID: 33942361

April 2021

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Cummins KD, Lee YG, Pajarillo R, Chun I, Shyu A, Highfill SL, Price A, Zhao L, Peng L, Granda B, Ramones M, Lu XM, Christian DA, Perazzelli J, Lacey SF, Roy NH, Burkhardt JK, Colomb F, Damra M, Abdel-Mohsen M, Liu T, Liu D, Standley DM, Young RM, Brogdon JL, Grupp SA, June CH, Maude SL, Gill S, Ruella M. Nat Med. 2021 Apr 22. doi: 10.1038/s41591-021-01326-5. Online ahead of print. PMID: 33888899
COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions. Adeniji OS, Giron LB, Purwar M, Zilberstein NF, Kulkarni AJ, Shaikh MW, Balk RA, Moy JN, Forsyth CB, Liu Q, Dweep H, Kossenkov A, Weiner DB, Keshavarzian A, Landay A, Abdel-Mohsen M. mBio. 2021 Apr 20;12(2):e00281-21. doi: 10.1128/mBio.00281-21.
PMID: 33879594
STARCH SYNTHASE5, a Noncanonical Starch Synthase-Like Protein, Promotes Starch Granule Initiation in Arabidopsis. Abt MR, Pfister B, Sharma M, Eicke S, Bürgy L, Neale I, Seung D, Zeeman SC. Plant Cell. 2020 Aug 3;32(8):2543-2565. doi: 10.1105/tpc.19.00946. PMID: 33822996
Living Donor Liver Transplantation: Is Recipient Age a Barrier? Abu-Gazala S, Abt PL. Liver Transpl. 2021 Apr 27. doi: 10.1002/lt.26085. Online ahead of print. PMID: 33905597
Occult Hepatocellular Carcinoma Associated with Transjugular Intrahepatic Portosystemic Shunts in Liver Transplant Recipients. Krumeich LN, Mancinelli J, Cucchiara A, Eddinger K, Aufhauser D, Goldberg DW, Siegelman ES, Rosen M, Reddy KR, Hoteit M, Furth EE, Olthoff KM, Shaked A, Levine M, Abt P. Liver Transpl. 2021 Apr 14. doi: 10.1002/lt.26073. Online ahead of print. PMID: 33853207
Determinants of kidney transplant candidates' decision to accept organ donor intervention transplants and participate in post-transplant research: A conjoint analysis. Gordon EJ, Abt P, Lee J, Knopf E, Phillips C, Bermudez F, Krishnamurthi L, Karaca HS, Veatch R, Knight R, Conway PT, Dunn S, Reese PP. Clin Transplant. 2021 Apr 12:e14316. doi: 10.1111/ctr.14316. Online ahead of print. PMID: 33844367
A response to Kong et al.'s January 2021 article "Cannabinoids in dermatologic surgery". Abdalla T, Lytvyn Y, McDonald KA, Mufti A, Alavi A. J Am Acad Dermatol. 2021 Apr 26:S0190-9622(21)00912-9. doi: 10.1016/j.jaad.2021.04.068. Online ahead of print. PMID: 33915241
Coexistence of Hidradenitis Suppurativa and Steatocystoma Multiplex; Is It a New Variant of Hidradenitis Suppurativa? Fletcher J, Posso-De Los Rios C, Jambrosic J, Alavi A. J Cutan Med Surg. 2021 Apr 28:12034754211010145. doi: 10.1177/12034754211010145. Online ahead of print. PMID: 33908804
National Marrow Donor Program-Sponsored Multicenter, Phase II Trial of HLA-Mismatched Unrelated Donor Bone Marrow Transplantation Using Post-Transplant Cyclophosphamide. Shaw BE, Jimenez-Jimenez AM, Burns LJ, Logan BR, Khimani F, Shaffer BC, Shah NN, Mussetter A, Tang XY, McCarty JM, Alavi A, Farhadfar N, Jamieson K, Hardy NM, Choe H, Ambinder RF, Anasetti C, Perales MA, Spellman SR, Howard A, Komanduri KV, Luznik L, Norkin M, Pidala JA, Ratanatharathorn V, Confer DL, Devine SM, Horowitz MM, Bolaños-Meade J. J Clin Oncol. 2021 Apr 27:JCO2003502. doi: 10.1200/JCO.20.03502. Online ahead of print. PMID: 33905264
Carotid artery molecular calcification assessed by [¹⁸F]fluoride PET/CT: correlation with cardiovascular and thromboembolic risk factors. Castro SA, Muser D, Lee H, Hancin EC, Borja AJ, Acosta O, Werner TJ, Thomassen A, Constantinescu C, Høilund-Carlsen PF, Alavi A. Eur Radiol. 2021 Apr 17. doi: 10.1007/s00330-021-07917-7. Online ahead of print.
PMID: 33866386
Wound Bed Preparation 2021. Sibbald RG, Elliott JA, Persaud-Jaimangal R, Goodman L, Armstrong DG, Harley C, Coelho S, Xi N, Evans R, Mayer DO, Zhao X, Heil J, Kotru B, Delmore B, LeBlanc K, Ayello EA, Smart H, Tariq G, Alavi A, Somayaji R. Adv Skin Wound Care. 2021 Apr 1;34(4):183-195. doi: 10.1097/01.ASW.0000733724.87630.d6. PMID: 33739948
Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs. Ali H. Curr Opin Immunol. 2021 Apr 12;72:65-71. doi: 10.1016/j.coi.2021.03.011. Online ahead of print. PMID: 33857758 Review.
Disruption of the blood-brain barrier in 22q11.2 deletion syndrome. Crockett AM, Ryan SK, Vásquez AH, Canning C, Kanyuch N, Kebir H, Ceja G, Gesualdi J, Zackai E, McDonald-McGinn D, Viaene A, Kapoor R, Benallegue N, Gur R, Anderson SA, Alvarez JI. Brain. 2021 Apr 20:awab055. doi: 10.1093/brain/awab055. Online ahead of print. PMID: 33876226
Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances. Bar-Or A, Li R. Lancet Neurol. 2021 Apr 27:S1474-4422(21)00063-6. doi: 10.1016/S1474-4422(21)00063-6. Online ahead of print. PMID: 33930317 Review.
Effect of continuous positive airway pressure treatment of obstructive sleep apnea-hypopnea in multiple sclerosis: A randomized, double-blind, placebo-controlled trial (SAMS-PAP study). Khadadah S, Kimoff RJ, Duquette P, Jobin V, Lapierre Y, Benedetti A, Johara FT, Robinson A, Roger E, Bar-Or A, Leonard G, Kaminska M, Trojan DA. Mult Scler. 2021 Apr 23:13524585211010390. doi: 10.1177/13524585211010390. Online ahead of print. PMID: 33890515
Proteomic Profiling of MIS-C Patients Reveals Heterogeneity Relating to Interferon Gamma Dysregulation and Vascular Endothelial Dysfunction. Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrell A, Lambert MP, Sullivan KE, John Wherry E, Teachey DT, Bassiri H, Behrens EM. medRxiv. 2021 Apr 20:2021.04.13.21255439. doi: 10.1101/2021.04.13.21255439. Preprint.
HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury. Aufhauser DD Jr, Hernandez P, Concors SJ, O'Brien C, Wang Z, Murken DR, Samanta A, Beier UH, Krumeich L, Bhatti TR, Wang Y, Ge G, Wang L, Cheraghlou S, Wagner FF, Holson EB, Kalin JH, Cole PA, Hancock WW, Levine MH. Sci Rep. 2021 Apr 27;11(1):9018. doi: 10.1038/s41598-021-88242-3. PMID: 33907245
Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γsignature. Farias Amorim C, O Novais F, Nguyen BT, Nascimento MT, Lago J, Lago AS, Carvalho LP, Beiting DP, Scott P. PLoS Negl Trop Dis. 2021 Apr 1;15(4):e0009321. doi: 10.1371/journal.pntd.0009321. Online ahead of print. PMID: 33793565
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination. Goel RR, Apostolidis SA, Painter MM, Mathew D, Pattekar A, Kuthuru O, Gouma S, Hicks P, Meng W, Rosenfeld AM, Dysinger S, Lundgreen KA, Kuri-Cervantes L, Adamski S, Hicks A, Korte S, Oldridge DA, Baxter AE, Giles JR, Weirick ME, McAllister CM, Dougherty J, Long S, D'Andrea K, Hamilton JT, Betts MR, Luning Prak ET, Bates P, Hensley SE, Greenplate AR, Wherry EJ. Sci Immunol. 2021 Apr 15;6(58):eabi6950. doi: 10.1126/sciimmunol.abi6950. PMID: 33858945
BCR-Induced Ca²⁺ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells. Berry CT, Liu X, Myles A, Nandi S, Chen YH, Hershberg U, Brodsky IE, Cancro MP, Lengner CJ, May MJ, Freedman BD. Cell Rep. 2020 Apr 14;31(2):107474. doi: 10.1016/j.celrep.2020.03.038. PMID: 32294437
Immune dysregulation in human ITCH deficiency successfully treated with hematopoietic cell transplantation. Patel T, Henrickson SE, Moser EK, Field NS, Maurer K, Dawany N, Conrad M, Bunin N, Freedman JL, Heimall J, Arnold DE, Wang J, Markowitz JE, Payne-Poff SB, Williams KW, Russo PA, Wherry EJ, Devoto M, Oliver P, Sullivan KE, Kelsen JR. J Allergy Clin Immunol Pract. 2021 Apr 21:S2213-2198(21)00450-5. doi: 10.1016/j.jaip.2021.04.010. Online ahead of print. PMID: 33894394
Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Cummins KD, Lee YG, Pajarillo R, Chun I, Shyu A, Highfill SL, Price A, Zhao L, Peng L, Granda B, Ramones M, Lu XM, Christian DA, Perazzelli J, Lacey SF, Roy NH, Burkhardt JK, Colomb F, Damra M, Abdel-Mohsen M, Liu T, Liu D, Standley DM, Young RM, Brogdon JL, Grupp SA, June CH, Maude SL, Gill S, Ruella M. Nat Med. 2021 Apr 22. doi: 10.1038/s41591-021-01326-5. Online ahead of print. PMID: 33888899
Foramen Magnum Dural Arteriovenous Fistula Presenting With Thoracic Myelopathy: Technical Case Report With 2-Dimensional Operative Video. Gadot R, Gopakumar S, Wagner K, Xu DS, Raper DMS, Burkhardt JK, Ropper AE. Oper Neurosurg (Hagerstown). 2021 Apr 7:opab077. doi: 10.1093/ons/opab077. Online ahead of print. PMID: 33825904
Crossing the Carotid Siphon: Techniques to Facilitate Distal Access in Tortuous Anatomy: 2-Dimensional Operative Video. Hadley C, Burkhardt JK, Johnson JN, Kan P; Endovascular Neurosurgery Research Group. Oper Neurosurg (Hagerstown). 2021 Apr 2:opab084. doi: 10.1093/ons/opab084. Online ahead of print. PMID: 33822191
Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation. Li L, Zhang X, Wang X, Kim SW, Herndon JM, Becker-Hapak MK, Carreno BM, Myers NB, Sturmoski MA, McLellan MD, Miller CA, Johanns TM, Tan BR, Dunn GP, Fleming TP, Hansen TH, Goedegebuure SP, Gillanders WE. Genome Med. 2021 Apr 21;13(1):56. doi: 10.1186/s13073-021-00872-4. PMID: 33879241
Empirical Mode Decomposition-Derived Entropy Features Are Beneficial to Distinguish Elderly People with a Falling History on a Force Plate Signal. Chou LW, Chang KM, Wei YC, Lu MK. Entropy (Basel). 2021 Apr 16;23(4):472. doi: 10.3390/e23040472. PMID: 33923557
Disseminated Kaposi sarcoma with cytokine release in an AIDS patient. Chang KM, Hsieh SL, Harris CA. J Microbiol Immunol Infect. 2021 Apr 8:S1684-1182(21)00088-8. doi: 10.1016/j.jmii.2021.03.019. PMID: 33893052 No abstract available.
Mucormycosis after Coronavirus disease 2019 infection in a heart transplant recipient - Case report and review of literature. Khatri A, Chang KM, Berlinrut I, Wallach F. J Mycol Med. 2021 Apr 2;31(2):101125. doi: 10.1016/j.mycmed.2021.101125. PMID: 33857916

March 2021

Impact of Advanced Renal Dysfunction on Posttransplant Outcomes After Living Donor Liver Transplantation in the United States. Bittermann T, Abt PL, Olthoff KM, Kaur N, Heimbach JK, Emamaullee J. Transplantation. 2021 Mar 2. doi: 10.1097/TP.0000000000003728. Online ahead of print. PMID: 33660658
The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation. Benallegue N, Kebir H, Kapoor R, Crockett A, Li C, Cheslow L, Abdel-Hakeem MS, Gesualdi J, Miller MC, Wherry EJ, Church ME, Blanco MA, Alvarez JI. Brain. 2021 Mar 16:awab083. doi: 10.1093/brain/awab083. Online ahead of print. PMID: 33723591
Deep learning segmentation of orbital fat to calibrate conventional MRI for longitudinal studies. Brown RA, Fetco D, Fratila R, Fadda G, Jiang S, Alkhawajah NM, Yeh EA, Banwell B, Bar-Or A, Arnold DL; Canadian Pediatric Demyelinating Disease Network.Neuroimage. 2020 Mar;208:116442. doi: 10.1016/j.neuroimage.2019.116442. Epub 2019 Dec 9. PMID: 31821865
Gene Therapy for Inherited Bleeding Disorders. Arruda VR, Weber J, Samelson-Jones BJ. Semin Thromb Hemost. 2021 Mar;47(2):161-173. doi: 10.1055/s-0041-1722862. Epub 2021 Feb 26. PMID: 33636747
Evolutionary insights into coagulation factor IX Padua and other high-specific-activity variants. Samelson-Jones BJ, Finn JD, Raffini LJ, Merricks EP, Camire RM, Nichols TC, Arruda VR. Blood Adv. 2021 Mar 9;5(5):1324-1332. doi: 10.1182/bloodadvances.2019000405. PMID: 33656538
B cell activating factor modulates the factor VIII immune response in hemophilia A. Doshi BS, Rana J, Castaman G, Shaheen MA, Kaczmarek R, Butterfield JSS, Meeks SL, Leissinger C, Biswas M, Arruda VR. J Clin Invest. 2021 Mar 2:142906. doi: 10.1172/JCI142906. Online ahead of print. PMID: 33651716
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. Vella LA,Giles JR, Baxter AE, Oldridge DA, Diorio C, Kuri-Cervantes L, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen CJ, Conrey PE, Sayed S, Giannini HM, D'Andrea K; UPenn COVID Processing Unit, Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MR, Wherry EJ. Sci Immunol. 2021 Mar 2;6(57):eabf7570. doi: 10.1126/sciimmunol.abf7570. PMID: 33653907
Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis. Si SJ, Tasian SK, Bassiri H, Fisher BT, Atalla J, Patel R, Romberg N, Lambert MP, Paessler M, Behrens EJ, Teachey DT, Sullivan KE. J Clin Immunol. 2021 Mar 24:1-6. doi: 10.1007/s10875-021-01025-3. Online ahead of print. PMID: 33761058
Combined use of emapalumab and ruxolitinib in a patient with refractory hemophagocytic lymphohistiocytosis was safe and effective. Triebwasser MP, Barrett DM, Bassiri H, Bunin N, Elgarten C, Freedman J, Geera AS, Monos D, Lambert MP, Olson T, Seif AE, Paessler M, Petrosa W, Reilly AF, Romberg N, Sullivan KE, Quinn GZ, Behrens E, Teachey DT. Pediatr Blood Cancer. 2021 Mar 22:e29026. doi: 10.1002/pbc.29026. Online ahead of print. PMID: 33754483
Longitudinal Analysis Reveals Distinct Antibody and Memory B Cell Responses in SARS-CoV2 Naïve and Recovered Individuals Following mRNA Vaccination. Goel RR, Apostolidis SA, Painter MM, Mathew D, Pattekar A, Kuthuru O, Gouma S, Kuri-Cervantes L, Meng W, Adamski S, Baxter AE, Giles JR, Weirick ME, McAllister CM, Hicks A, Korte S, Dougherty J, Long S, D'Andrea K, Hamilton JT, Luning Prak ET, Betts MR, Bates P, Hensley SE, Greenplate AR, Wherry EJ. medRxiv. 2021 Mar 6:2021.03.03.21252872. doi: 10.1101/2021.03.03.21252872. Preprint. PMID: 33688691
Effects of sheared chromatin length on ChIP-seq quality and sensitivity. Keller CA, Wixom AQ, Heuston EF, Giardine B, Hsiung CC, Long MR, Miller A, Anderson SM, Cockburn A, Blobel GA, Bodine DM, Hardison RC. G3 (Bethesda). 2021 Mar 31:jkab101. doi: 10.1093/g3journal/jkab101. Online ahead of print. PMID: 33788948
Jack-of-all-trades: itaconate tolerizes NLRP3 inflammasome activation. Fischer NL, Shin S, Brodsky IE. Cell Rep. 2021 Mar 9;34(10):108855. doi: 10.1016/j.celrep.2021.108855. PMID: 33691120
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Dynamics Tracking. Chen H, Li Z, Feng S, Wang A, Richard-Greenblatt M, Hutson E, Andrianus S, Glaser LJ, Rodino KG, Qian J, Jayaraman D, Collman RG, Glascock A, Bushman FD, Lee JS, Cherry S, Fausto A, Weiss SR, Koo H, Corby PM, O'Doherty U, Garfall AL, Vogl DT, Stadtmauer EA, Wang P. medRxiv. 2021 Mar 26:2021.03.17.21253847. doi: 10.1101/2021.03.17.21253847. Preprint. PMID: 33791710
Detection of Microbial Agents in Oropharyngeal and Nasopharyngeal Samples of SARS-CoV-2 Patients. Seckar T, Lin X, Bose D, Wei Z, Rohrbaugh J, Collman RG, Robertson ES. Front Microbiol. 2021 Mar 9;12:637202. doi: 10.3389/fmicb.2021.637202. eCollection 2021. PMID: 33790878
Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function. Weiss SL, Bittinger K, Lee JJ, Friedman ES, Mattei LM, Graham K, Zhang D, Bush J, Balamuth F, McGowan FX Jr, Bushman FD, Baldassano RN, Wu GD, Wallace DC, Collman RG. Crit Care Explor. 2021 Mar 17;3(3):e0360. doi: 10.1097/CCE.0000000000000360. eCollection 2021 Mar. PMID: 33786436
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses. Russell RM, Bibollet-Ruche F, Liu W, Sherrill-Mix S, Li Y, Connell J, Loy DE, Trimboli S, Smith AG, Avitto AN, Gondim MVP, Plenderleith LJ, Wetzel KS, Collman RG, Ayouba A, Esteban A, Peeters M, Kohler WJ, Miller RA, François-Souquiere S, Switzer WM, Hirsch VM, Marx PA, Piel AK, Stewart FA, Georgiev AV, Sommer V, Bertolani P, Hart JA, Hart TB, Shaw GM, Sharp PM, Hahn BH. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2025914118. doi: 10.1073/pnas.2025914118. PMID: 33771926
Dynamic Changes in the Nasal Microbiome Associated with Disease Activity in Patients with Granulomatosis with Polyangiitis. Rhee RL, Lu J, Bittinger K, Lee JJ, Mattei LM, Sreih AG, Chou S, Miner JJ, Cohen NA, Kelly BJ, Lee H, Grayson PC, Collman RG, Merkel PA. Arthritis Rheumatol. 2021 Mar 7. doi: 10.1002/art.41723. Online ahead of print. PMID: 33682371
Green giant-a tiny chloroplast genome with mighty power to produce high-value proteins: history and phylogeny. Daniell H, Jin S, Zhu XG, Gitzendanner MA, Soltis DE, Soltis PS. Plant Biotechnol J. 2021 Mar;19(3):430-447. doi: 10.1111/pbi.13556. Epub 2021 Feb 22. PMID: 33484606
Longitudinal Changes in Prorenin and Renin in the Chronic Renal Insufficiency Cohort. Cho ME, Sweeney C, Fino N, Greene T, Ramkumar N, Huang Y, Ricardo AC, Shafi T, Deo R, Anderson A, Mills KT, Cheung AK; CRIC Study Investigators. Am J Nephrol. 2021 Mar 18:1-11. doi: 10.1159/000514302. Online ahead of print. PMID: 33735863
COVID-19 vaccine response in pregnant and lactating women: a cohort study. Gray KJ, Bordt EA, Atyeo C, Deriso E, Akinwunmi B, Young N, Medina Baez A, Shook LL, Cvrk D, James K, De Guzman R, Brigida S, Diouf K, Goldfarb I, Bebell LM, Yonker LM, Fasano A, Rabi SA, Elovitz MA, Alter G, Edlow AG. Am J Obstet Gynecol. 2021 Mar 24:S0002-9378(21)00187-3. doi: 10.1016/j.ajog.2021.03.023. Online ahead of print. PMID: 33775692
Maternal gut microbiota reflecting poor diet quality is associated with spontaneous preterm birth in a prospective cohort study. Gershuni V, Li Y, Elovitz M, Li H, Wu GD, Compher CW. Am J Clin Nutr. 2021 Mar 11;113(3):602-611. doi: 10.1093/ajcn/nqaa361. PMID: 33515003
Emerging role of 18F-FDG PET/CT in Castleman disease: a review. Koa B, Borja AJ, Aly M, Padmanabhan S, Tran J, Zhang V, Rojulpote C, Pierson SK, Tamakloe MA, Khor JS, Werner TJ, Fajgenbaum DC, Alavi A, Revheim ME. Insights Imaging. 2021 Mar 11;12(1):35. doi: 10.1186/s13244-021-00963-1. PMID: 33709329
Development of quality indicators for the diagnosis and management of achalasia. Kamal AN, Kathpalia P, Otaki F, Bredenoord AJ, Castell DO, Clarke JO, Falk GW, Fass R, Prakash Gyawali C, Kahrilas PJ, Katz PO, Katzka DA, Pandolfino JE, Penagini R, Richter JE, Roman S, Savarino E, Triadafilopoulos G, Vaezi MF, Vela MF, Leiman DA. Neurogastroenterol Motil. 2021 Mar 15:e14118. doi: 10.1111/nmo.14118. Online ahead of print. PMID: 33720448
Age of diagnosis in familial Barrett's associated neoplasia. Glamour BK, Alaber O, Cioffi G, Chandar AK, Barnholtz-Sloan J, Brock W, Falk GW, Canto MI, Wang JS, Iyer PG, Shaheen NJ, Grady WM, Abrams JA, Thota PN, Chak A, Blum AE. Fam Cancer. 2021 Mar 11. doi: 10.1007/s10689-021-00239-z. Online ahead of print. PMID: 33694069
Clinical Research after COVID-19: Embracing a New Normal. Gelfand JM, Hefele BE. J Invest Dermatol. 2021 Mar;141(3):481-483. doi: 10.1016/j.jid.2020.08.004. Epub 2020 Sep 2. PMID: 32890628
Remote intervention engagement and outcomes in the Clinical Trials in Organ Transplantation in Children consortium multisite trial. Duncan-Park S, Dunphy C, Becker J, D'Urso C, Annunziato R, Blatter J, Conrad C, Goldfarb SB, Hayes D Jr, Melicoff-Portillo E, Schecter M, Visner G, Armstrong B, Chin H, Kesler K, Williams NM, Odim JN, Sweet SC, Danziger-Isakov L, Shemesh E. Am J Transplant. 2021 Mar 22. doi: 10.1111/ajt.16567. Online ahead of print. PMID: 33752251
Epithelial cell transforming 2 is regulated by Yes-associated protein 1 and mediates pancreatic cancer progression and metastasis. Li C, Peng Z, Wang Y, Lam G, Nissen N, Tang J, Yuan X, Lewis M, Greene MI, Pandol SJ, Wang Q. Am J Physiol Gastrointest Liver Physiol. 2021 Mar 1;320(3):G380-G395. doi: 10.1152/ajpgi.00185.2020. Epub 2021 Jan 27. PMID: 33501895
Bacteria induce skin regeneration via IL-1β signaling. Wang G, Sweren E, Liu H, Wier E, Alphonse MP, Chen R, Islam N, Li A, Xue Y, Chen J, Chen Y, Lee S, Wang Y, Wang S, Archer NK, Andrews W, Kane MA, Dare E, Reddy SK, Hu Z, Grice EA, Miller LS, Garza LA. Cell Host Microbe. 2021 Mar 26:S1931-3128(21)00131-1. doi: 10.1016/j.chom.2021.03.003. Online ahead of print. PMID: 33798492
Glycolysis is integral to histamine-induced endothelial hyperpermeability. Ziogas A, Sajib MS, Lim JH, Alves TC, Das A, Witt A, Hagag E, Androulaki N, Grossklaus S, Gerlach M, Noll T, Grinenko T, Mirtschink P, Hajishengallis G, Chavakis T, Mikelis CM, Sprott D. FASEB J. 2021 Mar;35(3):e21425. doi: 10.1096/fj.202001634R. PMID: 33566443
Polymicrobial communities in periodontal disease: Their quasi-organismal nature and dialogue with the host. Hajishengallis G, Lamont RJ. Periodontol 2000. 2021 Mar 10. doi: 10.1111/prd.12371. Online ahead of print. PMID: 33690950 Review.
Phagocytosis of Apoptotic Cells in Resolution of Inflammation. Kourtzelis I, Hajishengallis G, Chavakis T. Front Immunol. 2020 Mar 31;11:553. doi: 10.3389/fimmu.2020.00553. eCollection 2020. PMID: 32296442
Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality. Dang MT, Gonzalez MV, Gaonkar KS, Rathi KS, Young P, Arif S, Zhai L, Alam Z, Devalaraja S, To TKJ, Folkert IW, Raman P, Rokita JL, Martinez D, Taroni JN, Shapiro JA, Greene CS, Savonen C, Mafra F, Hakonarson H, Curran T, Haldar M. Cell Rep. 2021 Mar 30;34(13):108917. doi: 10.1016/j.celrep.2021.108917. PMID: 33789113
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1. Zhang Y, Varela L, Szigeti-Buck K, Williams A, Stoiljkovic M, Šestan-Peša M, Henao-Mejia J, D'Acunzo P, Levy E, Flavell RA, Horvath TL, Kaczmarek LK. Nat Commun. 2021 Mar 19;12(1):1731. doi: 10.1038/s41467-021-22003-8. PMID: 33741962
SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2. Kiseleva AA, Troisi EM, Hensley SE, Kohli RM, Epstein JA. J Biochem. 2021 Mar 27:mvab041. doi: 10.1093/jb/mvab041. Online ahead of print. PMID: 33774672
Production of Human CRISPR-Engineered CAR-T Cells. Agarwal S, Wellhausen N, Levine BL, June CH. J Vis Exp. 2021 Mar 15;(169). doi: 10.3791/62299. PMID: 33779622
CAR T cells targeting CD13 controllably induce eradication of acute myeloid leukemia with a single domain antibody switch. He X, Feng Z, Ma J, Zhang X, Ling S, Cao Y, Xing B, Wu Y, Wang L, Katona BW, June CH, Hua X. Leukemia. 2021 Mar 12. doi: 10.1038/s41375-021-01208-2. Online ahead of print. PMID: 33712688
External Validation of the VOCAL-Penn Cirrhosis Surgical Risk Score in Two Large, Independent Health Systems. Mahmud N, Fricker Z, Panchal S, Lewis JD, Goldberg DS, Kaplan DE. Liver Transpl. 2021 Mar 31. doi: 10.1002/lt.26060. Online ahead of print. PMID: 33788365
SACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation. Kaplan DE, Mehta R, Garcia-Tsao G, Albrecht J, Aytaman A, Baffy G, Bajaj J, Hernaez R, Hunt K, Ioannou G, Johnson K, Kanwal F, Lee TH, Monto A, Pandya P, Schaubel D, Taddei TH. Contemp Clin Trials. 2021 Mar 24;104:106367. doi: 10.1016/j.cct.2021.106367. Online ahead of print. PMID: 33771685
Race Adjustment in eGFR Equations Does Not Improve Estimation of Acute Kidney Injury Events in Patients with Cirrhosis. Mahmud N, Asrani SK, Reese PP, Kaplan DE, Taddei TH, Nadim MK, Serper M. Dig Dis Sci. 2021 Mar 24. doi: 10.1007/s10620-021-06943-1. Online ahead of print. PMID: 33761091
Notch signaling at the crossroads of innate and adaptive immunity. Vanderbeck A, Maillard I. J Leukoc Biol. 2021 Mar;109(3):535-548. doi: 10.1002/JLB.1RI0520-138R. Epub 2020 Jun 18. PMID: 32557824 Review.
IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity. Garcia de Mattos Barbosa M, Liu H, Huynh D, Shelley G, Keller ET, Emmer BT, Sherman EJ, Ginsburg D, Kennedy AA, Tai AW, Wobus CE, Mirabelli C, Lanigan TM, Samaniego M, Meng W, Rosenfeld AM, Luning Prak ET, Platt JL, Cascalho M. JCI Insight. 2021 Mar 26:147386. doi: 10.1172/jci.insight.147386. Online ahead of print. PMID: 33769311
Pulmonary Involvement in Primary Systemic Vasculitides. Makhzoum JP, Grayson PC, Ponte C, Robson J, Suppiah R, Watts RA, Luqmani R, Merkel PA, Pagnoux C; DCVAS collaborators. Rheumatology (Oxford). 2021 Mar 31:keab325. doi: 10.1093/rheumatology/keab325. Online ahead of print. PMID: 33788906
Dynamic Changes in the Nasal Microbiome Associated with Disease Activity in Patients with Granulomatosis with Polyangiitis. Rhee RL, Lu J, Bittinger K, Lee JJ, Mattei LM, Sreih AG, Chou S, Miner JJ, Cohen NA, Kelly BJ, Lee H, Grayson PC, Collman RG, Merkel PA. Arthritis Rheumatol. 2021 Mar 7. doi: 10.1002/art.41723. Online ahead of print. PMID: 33682371
Hypertension in Children and Adolescents with Turner Syndrome (TS), Neurofibromatosis 1 (NF1), and Williams Syndrome (WS). Sivasubramanian R, Meyers KE. Curr Hypertens Rep. 2021 Mar 29;23(4):18. doi: 10.1007/s11906-021-01136-7. PMID: 33779870 Review.
Association of Obesity with Cardiovascular Risk Factors and Kidney Disease Outcomes in Primary Proteinuric Glomerulopathies. Shah PP, Brady TM, Meyers KEC, O'Shaughnessy MM, Gibson KL, Srivastava T, Zee J, Cattran D, Tuttle KR, Gadegbeku C, Glenn D, Derebail V, Smith A, Wang CS, Gillespie BW, Bitzer M, Sethna CB. Nephron. 2021 Mar 5:1-11. doi: 10.1159/000513869. Online ahead of print. PMID: 33677435
Updated international expert recommendations for the management of autoimmune bullous diseases during the COVID-19 pandemic. Kasperkiewicz M, Schmidt E, Amagai M, Fairley JA, Joly P, Murrell DF, Payne AS, Yale ML, Zillikens D, Woodley DT. J Eur Acad Dermatol Venereol. 2021 Mar 2:10.1111/jdv.17207. doi: 10.1111/jdv.17207. Online ahead of print. PMID: 33655539
Survival time of juvenile dogs with oral squamous cell carcinoma treated with surgery alone: A Veterinary Society of Surgical Oncology retrospective study. Sharma S, Boston SE, Skinner OT, Perry JA, Verstraete FJM, Lee DB, Van Stee LLL, Thompson C, Boylan M, McKee T, Bergman PJ. Vet Surg. 2021 Mar 27. doi: 10.1111/vsu.13625. Online ahead of print. PMID: 33772819
Personalized cancer vaccine strategy elicits polyfunctional T cells and demonstrates clinical benefits in ovarian cancer. Tanyi JL, Chiang CL, Chiffelle J, Thierry AC, Baumgartener P, Huber F, Goepfert C, Tarussio D, Tissot S, Torigian DA, Nisenbaum HL, Stevenson BJ, Guiren HF, Ahmed R, Huguenin-Bergenat AL, Zsiros E, Bassani-Sternberg M, Mick R, Powell DJ Jr, Coukos G, Harari A, Kandalaft LE. NPJ Vaccines. 2021 Mar 15;6(1):36. doi: 10.1038/s41541-021-00297-5. PMID: 33723260
Laboratory, Clinical, and Survival Outcomes Associated With Peptide Receptor Radionuclide Therapy in Patients With Gastroenteropancreatic Neuroendocrine Tumors. Kipnis ST, Hung M, Kumar S, Heckert JM, Lee H, Bennett B, Soulen MC, Pryma DA, Mankoff DA, Metz DC, Eads JR, Katona BW. JAMA Netw Open. 2021 Mar 1;4(3):e212274. doi: 10.1001/jamanetworkopen.2021.2274. PMID: 33755166
High-specific-activity ¹³¹I-MIBG vs ¹⁷⁷Lu-DOTATATE targeted radionuclide therapy for metastatic pheochromocytoma and paraganglioma. Jha A, Taieb D, Carrasquillo JA, Pryma DA, Patel M, Millo C, de Herder WW, Del Rivero J, Crona J, Shulkin BL, Virgolini I, Chen AP, Mittal BR, Basu S, Dillon JS, Hope TA, Mari Aparici C, Iagaru A, Hicks RJ, Avram AM, Strosberg JR, Civelek AC, Lin FI, Pandit-Taskar N, Pacak K. Clin Cancer Res. 2021 Mar 8:clincanres.3703.2020. doi: 10.1158/1078-0432.CCR-20-3703. Online ahead of print. PMID: 33685867
Disrupting upstream translation in mRNAs is associated with human disease. Lee DSM, Park J, Kromer A, Baras A, Rader DJ, Ritchie MD, Ghanem LR, Barash Y. Nat Commun. 2021 Mar 9;12(1):1515. doi: 10.1038/s41467-021-21812-1. PMID: 33750777
Genome-first approach to rare EYA4 variants and cardio-auditory phenotypes in adults. Ahmadmehrabi S, Li B, Park J, Devkota B, Vujkovic M, Ko YA, Van Wagoner D, Tang WHW, Krantz I, Ritchie M; Regeneron Genetics Center, Brant J, Ruckenstein MJ, Epstein DJ, Rader DJ. Hum Genet. 2021 Mar 21. doi: 10.1007/s00439-021-02263-6. Online ahead of print. PMID: 33745059
Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection. Parzych EM, Gulati S, Zheng B, Bah MA, Elliott STC, Chu JD, Nowak N, Reed GW, Beurskens FJ, Schuurman J, Rice PA, Weiner DB, Ram S. mBio. 2021 Mar 16;12(2):e00242-21. doi: 10.1128/mBio.00242-21. PMID: 33727348
Activation of STING signaling pathway effectively blocks human coronavirus infection. Liu W, Reyes HM, Yang JF, Li Y, Stewart KM, Basil MC, Lin SM, Katzen J, Morrisey EE, Weiss SR, You J. J Virol. 2021 Mar 31:JVI.00490-21. doi: 10.1128/JVI.00490-21. Online ahead of print. PMID: 33789998
Highly multiplexed mass cytometry identifies the immunophenotype in the skin of Dermatomyositis. Patel J, Maddukuri S, Li Y, Bax C, Werth VP. J Invest Dermatol. 2021 Mar 22:S0022-202X(21)01014-9. doi: 10.1016/j.jid.2021.02.748. Online ahead of print. PMID: 33766508
Collaboration for the Management of Hydroxychloroquine. Rosenbaum JT, Costenbader KH, Desmarais J, Ginzler EM, Fett N, Goodman SM, O'Dell JR, Schmajuk G, Werth VP, Melles RB, Marmor MF. Ophthalmology. 2021 Mar 19:S0161-6420(21)00127-5. doi: 10.1016/j.ophtha.2021.02.015. Online ahead of print. PMID: 33752915
Managing interventional clinical trials in the setting of COVID-19: Experience in an autoimmune skin disease unit. Borucki R, Concha JSS, Burroughs J, Okawa J, Werth VP. JAAD Int. 2021 Mar;2:94-95. doi: 10.1016/j.jdin.2020.11.002. Epub 2020 Dec 9. PMID: 33733244
Guidelines for the use of prophylactic agents in pemphigus patients treated with rituximab depend on the individual patient's risk factors. Murrell DF, Joly P, Werth VP. J Am Acad Dermatol. 2021 Mar 10:S0190-9622(21)00510-7. doi: 10.1016/j.jaad.2021.03.018. Online ahead of print. PMID: 33713786
In vivo CD8⁺ T cell CRISPR screening reveals control by Fli1 in infection and cancer. Chen Z, Arai E, Khan O, Zhang Z, Ngiow SF, He Y, Huang H, Manne S, Cao Z, Baxter AE, Cai Z, Freilich E, Ali MA, Giles JR, Wu JE, Greenplate AR, Hakeem MA, Chen Q, Kurachi M, Nzingha K, Ekshyyan V, Mathew D, Wen Z, Speck NA, Battle A, Berger SL, Wherry EJ, Shi J. Cell. 2021 Mar 4;184(5):1262-1280.e22. doi: 10.1016/j.cell.2021.02.019. Epub 2021 Feb 25. PMID: 33636129
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells. Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Nat Immunol. 2021 Mar;22(3):370-380. doi: 10.1038/s41590-021-00868-7. Epub 2021 Feb 11. PMID: 33574619
Memory T-Cell Heterogeneity and Terminology. Muroyama Y, Wherry EJ. Cold Spring Harb Perspect Biol. 2021 Mar 29:a037929. doi: 10.1101/cshperspect.a037929. Online ahead of print. PMID: 33782027
Loss of IL-10 signaling promotes IL-22 dependent host defenses against acute Clostridioides difficile infection. Cribas ES, Denny JE, Maslanka JR, Abt MC.Infect Immun. 2021 Mar 1:IAI.00730-20. doi: 10.1128/IAI.00730-20. Online ahead of print. PMID: 33649048 PMCID: PMC8091099
Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺T cells. Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Nat Immunol. 2021 Mar 3. doi: 10.1038/s41590-021-00906-4. Online ahead of print. PMID: 33658708

February 2021

Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia. Levine L, Arany Z, Kern-Goldberger A, Koelper N, Lewey J, Sammel MD, Elovitz MA, Ky B. Hypertens Pregnancy 2021 Feb;40(1):44-49. PMID: 33345653 PMCID: PMC7856576
Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply is Limited. Ribas A, Sengupta R, Locke T, Zaidi SK, Campbell KM, Carethers JM, Jaffee EM, Wherry EJ, Soria JC, D'Souza G. Cancer Discovery 2021 Feb;11(2):233-236 PMID: 33355178
Cutaneous Findings in SARS-CoV-2-Associated Multisystem Inflammatory Disease in Children. Blatz AM, Oboite M, Chiotos K, Castelo-Soccio L, Odom John AR; Children’s Hospital of Philadelphia MIS-C Research Collaborative. Open Forum Infect Dis. 2021 Feb 16;8(3):ofab074. doi: 10.1093/ofid/ofab074. eCollection 2021 Mar. PMID: 33778091

January 2021

The vascular landscape of human cancer. Kahn BM, Lucas A, Alur R, Wengyn MD, Schwartz GW, Li J, Sun K, Maurer HC, Olive KP, Faryabi RB, Stanger B. J Clin Invest. 2021 Jan 19;131(2):e136655. PMID: 33258803 PMCID: PMC7810485.
ICTV Virus Taxonomy Profile: Redondoviridae. Abbas A, Taylor LJ, Collman RG, Bushman FD, Ictv Report Consortium. J Gen Virol. 2021 Jan;102(1). PMID: 33258767
CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study. O'Hara MH, O'Reilly EM, Varadhachary G, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Mick R, Gherardini PF, Kitch LJ, Xu J, Samuel T, Karakunnel J, Fairchild J, Bucktrout S, LaVallee TM, Selinsky C, Till JE, Carpenter EL, Alanio C, Byrne KT, Chen RO, Trifan OC, Dugan U, Horak C, Hubbard-Lucey VM, Wherry EJ, Ibrahim R, Vonderheide RH. Lancet Oncology 2021 Jan;22(1):118-131. PMID: 33387490

2020

December 2020

Global brain glucose uptake on 18F-FDG-PET/CT is influenced by chronic cardiovascular risk. Borja AJ, Hancin EC, Zhang V, Koa B, Bhattaru A, Rojulpote C, Detchou DK, Aly M, Kaghazchi F, Gerke O, Patil S, Gonuguntla K, Werner TJ, Revheim ME, Høilund-Carlsen PF, Alavi A. Nucl Med Commun. 2020 Dec 14. doi: 10.1097/MNM.0000000000001349. Online ahead of print. PMID: 33323870
Rubella virus-associated chronic inflammation in primary immunodeficiency diseases. Perelygina L, Icenogle J, Sullivan KE. Curr Opin Allergy Clin Immunol. 2020 Dec;20(6):574-581. PMID: 33044342 PMCID: PMC7730704
Magnetic resonance imaging-based partial volume-corrected 18F-sodium fluoride positron emission tomography in the femoral neck. Ayubcha C, Raynor WY, Borja AJ, Seraj SM, Rojulpote C, Werner TJ, Revheim ME, Rajapakse CS, Alavi A. Nucl Med Commun. 2020 Dec 9. doi: 10.1097/MNM.0000000000001344. Online ahead of print. PMID: 33306627
Derivation and investigation of the first human cell-based model of Beckwith-Wiedemann syndrome. Chang S, Hur SK, Naveh NSS, Thorvaldsen JL, French DL, Gagne AL, Jobaliya CD, Anguera MC, Bartolomei MS, Kalish JM. Epigenetics. 2020 Dec 10. doi: 10.1080/15592294.2020.1861172. Online ahead of print.PMID: 33300436
The Identity of Human Tissue-Emigrant CD8⁺ T Cells. Buggert M, Vella LA, Nguyen S, Wu VH, Chen Z, Sekine T, Perez-Potti A, Maldini CR, Manne S, Darko S, Ransier A, Kuri-Cervantes L, Japp AS, Brody IB, Ivarsson MA, Gorin JB, Rivera-Ballesteros O, Hertwig L, Antel JP, Johnson ME, Okoye A, Picker L, Vahedi G, Sparrelid E, Llewellyn-Lacey S, Gostick E, Sandberg JK, Björkström N, Bar-Or A, Dori Y, Naji A, Canaday DH, Laufer TM, Wells AD, Price DA, Frank I, Douek DC, Wherry EJ, Itkin MG, Betts MR. Cell. 2020 Dec 4:S0092-8674(20)31536-1. doi: 10.1016/j.cell.2020.11.019. Online ahead of print.PMID: 33306960
Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT. Blood Adv. 2020 Dec 8;4(23):6051-6063. doi: 10.1182/bloodadvances.2020003471.PMID: 33290544
American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID-19. Version 2. Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Ferris A, Kernan KF, Schulert GS, Seo P, Son MBF, Tremoulet AH, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta JJ. Arthritis Rheumatol. 2020 Dec 5. doi: 10.1002/art.41616. Online ahead of print.PMID: 33277976
SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19. Anderson EM, Diorio C, Goodwin EC, McNerney KO, Weirick ME, Gouma S, Bolton MJ, Arevalo CP, Chase J, Hicks P, Manzoni TB, Baxter AE, Andrea KP, Burudpakdee C, Lee JH, Vella LA, Henrickson SE, Harris RM, Wherry EJ, Bates P, Bassiri H, Behrens EM, Teachey DT, Hensley SE. J Pediatric Infect Dis Soc. 2020 Dec 2:piaa161. doi: 10.1093/jpids/piaa161. Online ahead of print.PMID: 33263756
A Pilot Study of Galunisertib Plus Stereotactic Body Radiotherapy in Patients with Advanced Hepatocellular Carcinoma. Reiss KA, Wattenberg MM, Damjanov N, Prechtel Dunphy E, Jacobs-Small M, Lubas MJ, Robinson J, Dicicco L, Garcia-Marcano L, Giannone MA, Karasic TB, Furth EE, Carpenter EL, Wojcieszynski AP, Vonderheide RH, Beatty GL, Ben-Josef E. Mol Cancer Ther. 2020 Dec 2:molcanther.0632.2020. doi: 10.1158/1535-7163.MCT-20-0632. Online ahead of print.PMID: 33268571

November 2020

Is it safe to eat in a restaurant if you have peanut allergy? Jonathan Spergel. Ann Allergy Astma Immunol. 2020 Nov; 125(5):499-500. PMID:33097165
Pathogenesis of heparin - induced thrombocytopenia. Gowthami Arepally, Douglas Cines. Transl Res. 2020 Nov;225:131-140. PMID: 32417430 PMCID: PMC7487042
From conception to COVID-19: an arduous journey of tribulations of racism and triumphs. Henry Daniell. Plant Biotechnol J. 2020 Nov;18(11):2147-2154. PMID: 32799416 PMCID: PMC7460971

October 2020

Anti-drug antibodies to TNF inhibitors in hidradenitis suppurativa: a systematic review. Lu JD, Milakovic M, Piguet V, Alavi A. Br J Dermatol. 2020 Oct 2. doi: 10.1111/bjd.19591. Online ahead of print. PMID: 33006769
Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers. Dorsey MJ, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, Chandra S, Chaudhury S, Chen K, Chong H, Cuvelier GDE, Dalal J, DeFelice ML, DeSantes KB, Forbes LR, Gillio A, Goldman F, Joshi AY, Kapoor N, Knutsen AP, Kobrynski L, Lieberman JA, Leiding JW, Oshrine B, Patel KP, Prockop S, Quigg TC, Quinones R, Schultz KR, Seroogy C, Shyr D, Siegel S, Smith AR, Torgerson TR, Vander Lugt MT, Yu LC, Cowan MJ, Buckley RH, Dvorak CC, Griffith LM, Haddad E, Kohn DB, Logan B, Notarangelo LD, Pai SY, Puck J, Pulsipher MA, Heimall J. J Clin Immunol. 2020 Oct 2. doi: 10.1007/s10875-020-00865-9. Online ahead of print.
PMID: 33006109
STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Paris AJ, Hayer KE, Oved JH, Avgousti DC, Toulmin SA, Zepp JA, Zacharias WJ, Katzen JB, Basil MC, Kremp MM, Slamowitz AR, Jayachandran S, Sivakumar A, Dai N, Wang P, Frank DB, Eisenlohr LC, Cantu E 3rd, Beers MF, Weitzman MD, Morrisey EE, Worthen GS. Nat Cell Biol. 2020 Oct;22(10):1197-1210. doi: 10.1038/s41556-020-0569-x. Epub 2020 Sep 28. PMID: 32989251
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies. Parker KR, Migliorini D, Perkey E, Yost KE, Bhaduri A, Bagga P, Haris M, Wilson NE, Liu F, Gabunia K, Scholler J, Montine TJ, Bhoj VG, Reddy R, Mohan S, Maillard I, Kriegstein AR, June CH, Chang HY, Posey AD Jr, Satpathy AT. Cell. 2020 Oct 1;183(1):126-142.e17. doi: 10.1016/j.cell.2020.08.022. Epub 2020 Sep 21. PMID: 32961131
Echocardiographic strain analysis reflects impaired ventricular function in youth with pediatric-onset systemic lupus erythematosus. Chang JC, Wang Y, Xiao R, Fedec A, Meyers KE, Tinker C, Natarajan SS, Knight AM, Weiss PF, Mercer-Rosa L. Echocardiography. 2020 Oct 3. doi: 10.1111/echo.14872. Online ahead of print. PMID: 33009676
Implications of Tattoos That Oral Healthcare Providers Should Consider. Bindakhil MA, Sollecito TP, Stoopler ET. Compend Contin Educ Dent.2020 Oct;41(9):e10-e11. PMID: 33001662
Erratum to: Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to mifraine headache. Siewert KM, Klarin D, Damrauer SM, Chang KM, Tsao PS, Assimes TL, Smith GD, Voight BF. Int J Epidemiol 2020 Oct 1;49(5):1759. PMID: 33280006 PMCID: PMC7746405.

September 2020

Pyoderma gangrenosum: proposed pathogenesis and current use of biologics with an emphasis on complement C5a inhibitor IFX-1. Lu JD, Milakovic M, Ortega-Loayza AG, Marzano AV, Alavi A. Expert Opin Investig Drugs. 2020 Sep 3. Online ahead of print. PMID: 32880206
Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome. Diorio C, Anderson EM, McNerney KO, Goodwin EC, Chase JC, Bolton MJ, Arevalo CP, Weirick ME, Gouma S, Vella LA, Henrickson SE, Chiotos K, Fitzgerald JC, Kilbaugh TJ, John ARO, Blatz AM, Lambert MP, Sullivan KE, Tartaglione MR, Zambrano D, Martin M, Lee JH, Young P, Friedman D, Sesok-Pizzini DA, Hensley SE, Behrens EM, Bassiri H, Teachey DT. Pediatr Blood Cancer. 2020 Sep 4:e28693. Online ahead of print. PMID: 32885904
Dural substitutes differentially interfere with imaging quality of sonolucent trans-cranioplasty ultrasound assessment in benchtop model. Flores A, Srinivasan VM, Gadot R, Kan P, Burkhardt JK. World Neurosurg. 2020 Sep 2:S1878-8750(20)31935-5. PMID: 32890844
Local complement activation is associated with primary graft dysfunction after lung transplantation. Kulkarni HS, Ramphal K, Ma L, Brown M, Oyster M, Speckhart KN, Takahashi T, Byers DE, Porteous MK, Kalman L, Hachem RR, Rushefski M, McPhatter J, Cano M, Kreisel D, Scavuzzo M, Mittler B, Cantu E 3rd, Pilely K, Garred P, Christie JD, Atkinson JP, Gelman AE, Diamond JM. JCI Insight. 2020 Sep 3;5(17):138358. PMID: 32750037
Validation of the Waterless Empirical Taste Test (WETT ®) Doty RL, Wylie C, Potter M. Behav Res Methods. 2020 Sep 3. PMID: 32885386
Chemosensory Dysfunction in COVID-19: Prevalences, Recovery Rates, and Clinical Associations on a Large Brazilian Sample. Brandão Neto D, Fornazieri MA, Dib C, Di Francesco RC, Doty RL, Voegels RL, Pinna FR. Otolaryngol Head Neck Surg. 2020 Sep 1:194599820954825. PMID: 32867582
Clinical research post COVID-19: Embracing a new normal. Gelfand JM, Hefele BE. J Invest Dermatol. 2020 Sep 2:S0022-202X(20)31979-5. PMID: 32890628 PMCID: PMC7466954
Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms. Singh BK, Lu W, Schmidt Paustian AM, Ge MQ, Koziol-White CJ, Flayer CH, Killingbeck SS, Wang N, Dong X, Riese MJ, Deshpande DA, Panettieri RA Jr, Haczku A, Kambayashi T. Sci Signal. 2019 Sep 3;12(597):eaax3332. PMID: 31481522 PMCID: PMC6996596
Hepatitis C Virus. Kaplan DE. Ann Intern Med. 2020 Sep 1;173(5):ITC33-ITC48. PMID: 32866406
Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses. Chen J, Harding SM, Natesan R, Tian L, Benci JL, Li W, Minn AJ, Asangani IA, Greenberg RA. Cell Rep. 2020 Sep 1;32(9):108080. PMID: 32877684
68 Ga-DOTATATE PET/CT quantification predicts response to somatostatin analog therapy in gastroenteropancreatic neuroendocrine tumors. Lee H, Eads JR, Pryma DA. Oncologist. 2020 Sep 4. PMID: 32886441
Anti-Inflammatory HDL Function, Incident Cardiovascular Events, and Mortality: A Secondary Analysis of the JUPITER Randomized Clinical Trial. Ajala ON, Demler OV, Liu Y, Farukhi Z, Adelman SJ, Collins HL, Ridker PM, Rader DJ, Glynn RJ, Mora S. J Am Heart Assoc. 2020 Sep;9(17):e016507. Aug 15. PMID: 32799709
Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID) in the US Immunodeficiency Network (USIDNet) Registry. Kuo CY, Garabedian E, Puck J, Cowan MJ, Sullivan KE, Buckley RH, Cunningham-Rundles C, Marsh R, Candotti F, Kohn DB. J Clin Immunol.2020 Sep 2. PMID: 32880085
Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala. O'Leary TP, Sullivan KE, Wang L, Clements J, Lemire AL, Cembrowski MS. Elife. 2020 Sep 1;9:e59003. PMID: 32869744
Optimizing Therapy in the Modern Age: Differences in Length of Maintenance Therapy in Acute Lymphoblastic Leukemia. Teachey DT, Hunger SP, Loh ML. Blood. 2020 Sep 2:blood.2020007702. PMID: 32877503
PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma. Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA, Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. JCI Insight. 2020 Sep 3;5(17):133225. PMID: 32780726
Pioneer Transcription Factors Initiating Gene Network Changes. Zaret KS. Annu Rev Genet. 2020 Sep 4. PMID: 32886547

August 2020

Type 1 Conventional Dendritic Cells Are Systemically Dysregulated Early in Pancreatic Carcinogenesis. Lin JH, Huffman AP, Wattenberg MM, Walter DM, Carpenter EL, Feldser DM, Beatty GL, Furth EE, Vonderheide RH. J Exp Med. 2020 Aug 3;217(8). PMID: 32453421 PMCID: PMC7398166
Wide Variation in the Percentage of Donation After Circulatory Death Donors Across Donor Service Areas: A Potential Target for Improvement. Sonnenberg EM, Hsu JY, Reese PP, Goldberg DS, Abt PL. Transplantation. 2020 Aug;104(8):1668-1674. PMID: 32732846
Multiple roles for hepatitis B and C viruses and the host in the development of hepatocellular carcinoma. Wangensteen KJ, Chang KM. Hepatology. 2020 Aug 1. doi: 10.1002/hep.31481. Online ahead of print. PMID: 32737895
Hepatitis C virus modulates IgG glycosylation in HIV co-infected antiretroviral therapy suppressed individuals. Giron LB, Azzoni L, Yin X, Lynn KM, Ross BN, Fair M, Damra M, Sciorillo AC, Liu Q, Jacobson JM, Mounzer K, Kostman JR, Abdel-Mohsen M, Montaner LJ, Papasavvas E. AIDS. 2020 Aug 1;34(10):1461-1466. PMID: 32675559 PMCID: PMC7371238
ACR-ACNM-ASTRO-SNMMI Practice Parameter for the Performance of Therapy With Radium-223. Hurwitz M, Buscombe JR, Jacene HA, Klitzke AK, Lamonica D, Lu Y, Pryma DA, Rohren EM, Speer TW, Subramaniam RM, Thompson HM, Tomblyn MB, Wong WW, Xiao Y, Banks KP, Brown RKJ. Am J Clin Oncol. 2020 Aug;43(8):539-544. PMID: 32520788
Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [68Ga]Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies. Doot RK, Young AJ, Daube-Witherspoon ME, Alexoff D, Labban KJ, Lee H, Wu Z, Zha Z, Choi SR, Ploessl KH, Schubert EK, Lee H, Zhu L, Reddin JS, Karp JS, Kung H, Pryma DA. Nucl Med Biol. 2020 Jul-Aug;86-87:1-8. PMID: 32361089 PMCID: PMC7311273
Using scholarly productivity as an outcome assessment of a dental residency program. Stoopler ET, De Rossi SS, Greenberg MS, Sollecito TP. Spec Care Dentist. 2020 Sep 2. PMID: 32880996 No abstract available.
Introduction to dental medicine: Analysis of a massive open online course in dentistry. France K, Hangorsky U, Wu CW, Sollecito TP, Stoopler ET. J Dent Educ. 2020 Sep 2. PMID: 32876333
CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA, Zon LI. Proc Natl Acad Sci U S A. 2020 Sep 3:202003228. PMID: 32883883

July 2020

Evaluating the impact of prior authorizations in patients with complex dermatological conditions. Jew OS, Okawa J, Barbieri JS, McCaffrey J, Hayward E, Werth VP. J Am Acad Dermatol. 2020 Jul 1.
Good news for the treatment of narrow-caliber esophagus ineosinophilic esophagitis. Lynch KL, Falk GW. Gastrointest Endosc. 2020 Jul;92(1):54-55.
Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells. Su C, Johnson ME, Torres A, Thomas RM, Manduchi E, Sharma P, Mehra P, Le Coz C, Leonard ME, Lu S, Hodge KM, Chesi A, Pippin J, Romberg N, Grant SFA, Wells AD. Nat Commun. 2020 Jul 3;11(1):3294
Nucleic Acid Approaches to Antibody-based Therapeutics for COVID-19: A Perspective. Parzych E, Weiner DB. J Allergy Clin Immunol. 2020 Jul 2.
Recommendations for phototherapy during the COVID-19 pandemic. Lim HW, Feldman SR, Van Voorhees AS, Gelfand JM. J Am Acad Dermatol. 2020 Jul;83(1):287-288
Reply to: "Do IL-17 Inhibitors Increase Risk of Respiratory Tract Infections?" Wan MT, Shin DB, Winthrop KL, Gelfand JM. J Am Acad Dermatol. 2020 Jul 1.
The Risk of Respiratory Tract Infections in Psoriasis Patients Treated With IL-23-pathway Inhibiting Biologics: A Meta-Estimate of Pivotal Trials Relevant to Decision-Making During the COVID-19 Pandemic. Syed MN, Shin DB, Wan MT, Winthrop KL, Gelfand JM. J Am Acad Dermatol. 2020 Jul 2.
TOX is expressed by exhausted and polyfunctional human effector memory CD8 ⁺ T cells. Sekine T, Perez-Potti A, Nguyen S, Gorin JB, Wu VH, Gostick E, Llewellyn-Lacey S, Hammer Q, Falck-Jones S, Vangeti S, Yu M, Smed-Sörensen A, Gaballa A, Uhlin M, Sandberg JK, Brander C, Nowak P, Goepfert PA, Price DA, Betts MR, Buggert M. Sci Immunol. 2020 Jul 3;5(49).
Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells. Gao P, Chen C, Howell ED, Li Y, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann AF, Speck NA, Tan K. Genes Dev. 2020 Jul 1;34(13-14):950-964.
Predictors, Presentation, and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience. Ekpanyapong S, Philips N, Loza BL, Abt P, Furth EE, Tondon R, Khungar V, Olthoff K, Shaked A, Hoteit MA, Reddy KR. J Clin Exp Hepatol. 2020 Jul-Aug;10(4):304-315. doi: 10.1016/j.jceh.2019.11.003. Epub 2019 Nov 22. PMID: 32655233 PMCID: PMC7335705