Publications

Transcriptomic analysis-guided assessment of precision-cut tumor slices (PCTS) as an ex-vivo tool in cancer research. Trivedi S, Tilsed C, Liousia M, Brody RM, Rajasekaran K, Singhal S, Albelda SM, Klampatsa A. Sci Rep. 2024 May 14;14(1):11006. doi: 10.1038/s41598-024-61684-1. PMID: 38744944
Human IL-6 fosters long-term engraftment of patient derived disease-driving myeloma cells in immunodeficient mice. Hasanali ZS, Garfall AL, Burzenski L, Shultz LD, Tang Y, Kadu S, Sheppard NC, Liu W, Dopkin D, Vogl DT, Cohen AD, Waxman AJ, Susanibar-Adaniya SP, Carroll M, Stadtmauer EA, Allman D. JCI Insight. 2024 May 7:e177300. doi: 10.1172/jci.insight.177300. Online ahead of print. PMID: 38713510
Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis . Li R, Lei Y, Rezk A, Diego A Espinoza, Wang J, Feng H, Zhang B, Barcelos IP, Zhang H, Yu J, Huo X, Zhu F, Yang C, Tang H, Goldstein AC, Banwell BL, Hakonarson H, Xu H, Mingueneau M, Sun B, Li H, Bar-Or A. Sci Immunol. 2024 May 3;9(95):eadk0865. doi: 10.1126/sciimmunol.adk0865. Epub 2024 May 3. PMID: 38701189
Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins. Stone ML, Lee J, Lee JW, Coho H, Tariveranmoshabad M, Wattenberg MM, Choi H, Herrera VM, Xue Y, Choi-Bose S, Zingone SK, Patel D, Markowitz K, Delman D, Balachandran VP, Beatty GL. Nat Immunol. 2024 May;25(5):755-763. doi: 10.1038/s41590-024-01820-1. Epub 2024 Apr 19. PMID: 38641718
ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes. Lu Z, McBrearty N, Chen J, Tomar VS, Zhang H, De Rosa G, Tan A, Weljie AM, Beiting DP, Miao Z, George SS, Berger A, Saggu G, Diehl JA, Koumenis C, Fuchs SY. Cell Metab. 2024 May 7;36(5):1164-1167. doi: 10.1016/j.cmet.2024.04.002. Epub 2024 Apr 11. PMID: 38604169
Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation . Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE. Nat Commun. 2024 May 18;15(1):4235. doi: 10.1038/s41467-024-48589-3. PMID: 38762489
Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Chong ACN, Vandana JJ, Jeng G, Li G, Meng Z, Duan X, Zhang T, Qiu Y, Duran-Struuck R, Coker K, Wang W, Li Y, Min Z, Zuo X, de Silva N, Chen Z, Naji A, Hao M, Liu C, Chen S. Nat Chem Biol. 2024 May;20(5):566-576. doi: 10.1038/s41589-023-01466-4. Epub 2023 Nov 9. PMID: 37945898
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics . Mongia A, Zohora FT, Burget NG, Zhou Y, Saunders DC, Wang YJ, Brissova M, Powers AC, Kaestner KH, Vahedi G, Naji A, Schwartz GW, Faryabi RB. Nat Commun. 2024 May 3;15(1):3744. doi: 10.1038/s41467-024-47334-0. PMID: 38702321
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion. Uslu U, Sun L, Castelli S, Finck AV, Assenmacher CA, Young RM, Chen ZJ, June CH. Nat Commun. 2024 May 10;15(1):3933. doi: 10.1038/s41467-024-47692-9. PMID: 38730243
Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation. Berjis A, Muthumani D, Aguilar OA, Pomp O, Johnson O, Finck AV, Engel NW, Chen L, Plachta N, Scholler J, Lanier LL, June CH, Sheppard NC. Nat Commun. 2024 May 10;15(1):3937. doi: 10.1038/s41467-024-47574-0. PMID: 38729924
Alternative 3'UTR expression induced by T cell activation is regulated in a temporal and signal dependent manner. Blake D, Gazzara MR, Breuer I, Ferretti M, Lynch KW. Sci Rep. 2024 May 14;14(1):10987. doi: 10.1038/s41598-024-61951-1. PMID: 38745101
A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies. Liu X, Devadiga SA, Stanley RF, Morrow RM, Janssen KA, Quesnel-Vallières M, Pomp O, Moverley AA, Li C, Skuli N, Carroll MP, Huang J, Wallace DC, Lynch KW, Abdel-Wahab O, Klein PS. J Clin Invest. 2024 May 7:e175619. doi: 10.1172/JCI175619. Online ahead of print. PMID: 38713535
Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma. Tian M, Wei JS, Shivaprasad N, Highfill SL, Gryder BE, Milewski D, Brown GT, Moses L, Song H, Wu JT, Azorsa P, Kumar J, Schneider D, Chou HC, Song YK, Rahmy A, Masih KE, Kim YY, Belyea B, Linardic CM, Dropulic B, Sullivan PM, Sorensen PH, Dimitrov DS, Maris JM, Mackall CL, Orentas RJ, Cheuk AT, Khan J. Cell Rep Med. 2024 May 8:101586. doi: 10.1016/j.xcrm.2024.101586. Online ahead of print. PMID: 38723625
Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE. Nat Commun. 2024 May 18;15(1):4235. doi: 10.1038/s41467-024-48589-3. PMID: 38762489
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction. Jia G, Ping J, Guo X, Yang Y, Tao R, Li B, Ambs S, Barnard ME, Chen Y, Garcia-Closas M, Gu J, Hu JJ, Huo D, John EM, Li CI, Li JL, Nathanson KL, Nemesure B, Olopade OI, Pal T, Press MF, Sanderson M, Sandler DP, Shu XO, Troester MA, Yao S, Adejumo PO, Ahearn T, Brewster AM, Hennis AJM, Makumbi T, Ndom P, O'Brien KM, Olshan AF, Oluwasanu MM, Reid S, Butler EN, Huang M, Ntekim A, Qian H, Zhang H, Ambrosone CB, Cai Q, Long J, Palmer JR, Haiman CA, Zheng W. Nat Genet. 2024 May;56(5):819-826. doi: 10.1038/s41588-024-01736-4. Epub 2024 May 13. PMID: 38741014
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer. Sussman J, Kim NY, Kemp SB, Traum D, Katsuda T, Kahn BM, Xu J, Kim IK, Eskandarian C, Delman D, Beatty GL, Kaestner KH, Simpson AL, Stanger BZ. Cancer Res. 2024 May 2. doi: 10.1158/0008-5472.CAN-23-2352. Online ahead of print. PMID: 38695869
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics. Mongia A, Zohora FT, Burget NG, Zhou Y, Saunders DC, Wang YJ, Brissova M, Powers AC, Kaestner KH, Vahedi G, Naji A, Schwartz GW, Faryabi RB. Nat Commun. 2024 May 3;15(1):3744. doi: 10.1038/s41467-024-47334-0. PMID: 38702321
Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins. Stone ML, Lee J, Lee JW, Coho H, Tariveranmoshabad M, Wattenberg MM, Choi H, Herrera VM, Xue Y, Choi-Bose S, Zingone SK, Patel D, Markowitz K, Delman D, Balachandran VP, Beatty GL. Nat Immunol. 2024 May;25(5):755-763. doi: 10.1038/s41590-024-01820-1. Epub 2024 Apr 19. PMID: 38641718
FOXO1 is a master regulator of memory programming in CAR T cells. Doan AE, Mueller KP, Chen AY, Rouin GT, Chen Y, Daniel B, Lattin J, Markovska M, Mozarsky B, Arias-Umana J, Hapke R, Jung IY, Wang A, Xu P, Klysz D, Zuern G, Bashti M, Quinn PJ, Miao Z, Sandor K, Zhang W, Chen GM, Ryu F, Logun M, Hall J, Tan K, Grupp SA, McClory SE, Lareau CA, Fraietta JA, Sotillo E, Satpathy AT, Mackall CL, Weber EW. Nature. 2024 May;629(8010):211-218. doi: 10.1038/s41586-024-07300-8. Epub 2024 Apr 10. PMID: 38600391
Interferon signaling in the nasal epithelium distinguishes among lethal and common cold coronaviruses and mediates viral clearance. Otter CJ, Renner DM, Fausto A, Tan LH, Cohen NA, Weiss SR. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2402540121. doi: 10.1073/pnas.2402540121. Epub 2024 May 17. PMID: 38758698

Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection. Giron LB, Liu Q, Adeniji OS, Yin X, Kannan T, Ding J, Lu DY, Langan S, Zhang J, Azevedo JLLC, Li SH, Shalygin S, Azadi P, Hanna DB, Ofotokun I, Lazar J, Fischl MA, Haberlen S, Macatangay B, Adimora AA, Jamieson BD, Rinaldo C, Merenstein D, Roan NR, Kutsch O, Gange S, Wolinsky SM, Witt MD, Post WS, Kossenkov A, Landay AL, Frank I, Tien PC, Gross R, Brown TT, Abdel-Mohsen M. Nat Commun. 2024 Apr 10;15(1):3035. doi: 10.1038/s41467-024-47279-4. PMID: 38600088
Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade. Nie H, Saini P, Miyamoto T, Liao L, Zielinski RJ, Liu H, Zhou W, Wang C, Murphy B, Towers M, Yang T, Qi Y, Kannan T, Kossenkov A, Tateno H, Claiborne DT, Zhang N, Abdel-Mohsen M, Zhang R. Nat Commun. 2024 Apr 2;15(1):2853. doi: 10.1038/s41467-024-47069-y. PMID: 38565883
22q11.2 Deletion-Associated Blood-Brain Barrier Permeability Potentiates Systemic Capillary Leak Syndrome Neurologic Features. Crockett AM, Kebir H, Anderson SA, Jyonouchi S, Romberg N, Alvarez JI. J Clin Immunol. 2024 Apr 5;44(4):87. doi: 10.1007/s10875-024-01686-w. PMID: 38578402
Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome. Yehya N, Booth TJ, Ardhanari GD, Thompson JM, Lam LKM, Till JE, Mai MV, Keim G, McKeone DJ, Halstead ES, Lahni P, Varisco BM, Zhou W, Carpenter EL, Christie JD, Mangalmurti NS. J Clin Invest. 2024 Apr 4;134(10):e177896. doi: 10.1172/JCI177896. PMID: 38573766
The common variable immunodeficiency IgM repertoire narrowly recognizes erythrocyte and platelet glycans. Le Coz C, Trofa M, Butler DL, Yoon S, Tian T, Reid W, Cruz Cabrera E, Knox AVC, Khanna C, Sullivan KE, Heimall J, Takach P, Fadugba OO, Lawrence M, Jyonouchi S, Hakonarson H, Wells AD, Handler S, Zur KB, Pillai V, Gildersleeve JC, Romberg N. J Allergy Clin Immunol. 2024 Apr 29:S0091-6749(24)00418-4. doi: 10.1016/j.jaci.2024.04.018. Online ahead of print. PMID: 38692308
Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets. Patil AR, Schug J, Liu C, Lahori D, Descamps HC; Human Pancreas Analysis Consortium; Naji A, Kaestner KH, Faryabi RB, Vahedi G. Cell Rep Med. 2024 Apr 25:101535. doi: 10.1016/j.xcrm.2024.101535. Online ahead of print.PMID: 38677282
The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally. Harris JC, Trigg NA, Goshu B, Yokoyama Y, Dohnalová L, White EK, Harman A, Murga-Garrido SM, Ting-Chun Pan J, Bhanap P, Thaiss CA, Grice EA, Conine CC, Kambayashi T. Cell Rep. 2024 Apr 23;43(4):114029. doi: 10.1016/j.celrep.2024.114029. Epub 2024 Apr 4. PMID: 38573852
Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment. Fuller AM, Pruitt HC, Liu Y, Irizarry-Negron VM, Pan H, Song H, DeVine A, Katti RS, Devalaraja S, Ciotti GE, Gonzalez MV, Williams EF, Murazzi I, Ntekoumes D, Skuli N, Hakonarson H, Zabransky DJ, Trevino JG, Weeraratna A, Weber K, Haldar M, Fraietta JA, Gerecht S, Eisinger-Mathason TSK. J Clin Invest. 2024 Apr 23:e167826. doi: 10.1172/JCI167826. Online ahead of print. PMID: 38652549
The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally. Harris JC, Trigg NA, Goshu B, Yokoyama Y, Dohnalová L, White EK, Harman A, Murga-Garrido SM, Ting-Chun Pan J, Bhanap P, Thaiss CA, Grice EA, Conine CC, Kambayashi T. Cell Rep. 2024 Apr 23;43(4):114029. doi: 10.1016/j.celrep.2024.114029. Epub 2024 Apr 4. PMID: 38573852
Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment. Fuller AM, Pruitt HC, Liu Y, Irizarry-Negron VM, Pan H, Song H, DeVine A, Katti RS, Devalaraja S, Ciotti GE, Gonzalez MV, Williams EF, Murazzi I, Ntekoumes D, Skuli N, Hakonarson H, Zabransky DJ, Trevino JG, Weeraratna A, Weber K, Haldar M, Fraietta JA, Gerecht S, Eisinger-Mathason TSK. J Clin Invest. 2024 Apr 23:e167826. doi: 10.1172/JCI167826. Online ahead of print. PMID: 38652549
Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants. Johnston TS, Li SH, Painter MM, Atkinson RK, Douek NR, Reeg DB, Douek DC, Wherry EJ, Hensley SE. Immunity. 2024 Apr 9;57(4):912-925.e4. doi: 10.1016/j.immuni.2024.02.017. Epub 2024 Mar 14. PMID: 38490198
Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception. Gautam M, Yamada A, Yamada AI, Wu Q, Kridsada K, Ling J, Yu H, Dong P, Ma M, Gu J, Luo W. Nat Commun. 2024 Apr 4;15(1):2911. doi: 10.1038/s41467-024-47245-0. PMID: 38575590
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Morral C, Ayyaz A, Kuo HC, Fink M, Verginadis II, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, Ghinnagow R, Luo L, Ma Y, Attardi LD, Koumenis C, Minn AJ, Wrana JL, Lee CL, Kirsch DG. Nat Commun. 2024 Apr 8;15(1):3018. doi: 10.1038/s41467-024-47124-8. PMID: 38589357
Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets. Patil AR, Schug J, Liu C, Lahori D, Descamps HC; Human Pancreas Analysis Consortium; Naji A, Kaestner KH, Faryabi RB, Vahedi G. Cell Rep Med. 2024 Apr 25:101535. doi: 10.1016/j.xcrm.2024.101535. Online ahead of print. PMID: 38677282
SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling. Otter CJ, Bracci N, Parenti NA, Ye C, Asthana A, Blomqvist EK, Tan LH, Pfannenstiel JJ, Jackson N, Fehr AR, Silverman RH, Burke JM, Cohen NA, Martinez-Sobrido L, Weiss SR. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2320194121. doi: 10.1073/pnas.2320194121. Epub 2024 Apr 3. PMID: 38568967
Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analyses. Friedman CF, Manning-Geist BL, Zhou Q, Soumerai T, Holland A, Da Cruz Paula A, Green H, Ozsoy MA, Iasonos A, Hollmann T, Leitao MM Jr, Mueller JJ, Makker V, Tew WP, O'Cearbhaill RE, Liu YL, Rubinstein MM, Troso-Sandoval T, Lichtman SM, Schram A, Kyi C, Grisham RN, Causa Andrieu P, Wherry EJ, Aghajanian C, Weigelt B, Hensley ML, Zamarin D. Nat Med. 2024 Apr 23. doi: 10.1038/s41591-024-02942-7. Online ahead of print. PMID: 38653864

Neonatal CD8+ T Cells Resist Exhaustion during Chronic Infection. Maymí VI, Zhu H, Jager M, Johnson S, Getchell R, Casey JW, Grenier JK, Wherry EJ, Smith NL, Grimson A, Rudd BD . J Immunol. 2024 Mar 1;212(5):834-843. doi: 10.4049/jimmunol.2300396. PMID: 38231127
Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis. Cross AH, Gelfand JM, Thebault S, Bennett JL, von Büdingen HC, Cameron B, Carruthers R, Edwards K, Fallis R, Gerstein R, Giacomini PS, Greenberg B, Hafler DA, Ionete C, Kaunzner UW, Kodama L, Lock C, Longbrake EE, Musch B, Pardo G, Piehl F, Weber MS, Yuen S, Ziemssen T, Bose G, Freedman MS, Anania VG, Ramesh A, Winger RC, Jia X, Herman A, Harp C, Bar-Or A. JAMA Neurol. 2024 Mar 11. doi: 10.1001/jamaneurol.2024.0017. Online ahead of print. PMID: 38466277
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas. Matsuda R, Sorobetea D, Zhang J, Peterson ST, Grayczyk JP, Yost W, Apenes N, Kovalik ME, Herrmann B, O'Neill RJ, Bohrer AC, Lanza M, Assenmacher CA, Mayer-Barber KD, Shin S, Brodsky IE. J Exp Med. 2024 Mar 4;221(3):e20230679. doi: 10.1084/jem.20230679. Epub 2024 Feb 16. PMID: 38363547
The hyphal-specific toxin candidalysin promotes fungal gut commensalism. Liang SH, Sircaik S, Dainis J, Kakade P, Penumutchu S, McDonough LD, Chen YH, Frazer C, Schille TB, Allert S, Elshafee O, Hänel M, Mogavero S, Vaishnava S, Cadwell K, Belenky P, Perez JC, Hube B, Ene IV, Bennett RJ. Nature. 2024 Mar 6. doi: 10.1038/s41586-024-07142-4. Online ahead of print. PMID: 38448595
Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants. Johnston TS, Li SH, Painter MM, Atkinson RK, Douek NR, Reeg DB, Douek DC, Wherry EJ, Hensley SE. Immunity. 2024 Mar 8:S1074-7613(24)00093-1. doi: 10.1016/j.immuni.2024.02.017. Online ahead of print. PMID: 38490198
IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation. Tilsed CM, Sadiq BA, Papp TE, Areesawangkit P, Kimura K, Noguera-Ortega E, Scholler J, Cerda N, Aghajanian H, Bot A, Mui B, Tam Y, Weissman D, June CH, Albelda SM, Parhiz H. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2319856121. doi: 10.1073/pnas.2319856121. Epub 2024 Mar 21. PMID: 38513098
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics. Turner L, Van Le TN, Cross E, Queriault C, Knight M, Trihemasava K, Davis J, Schaefer P, Nguyen J, Xu J, Goldspiel B, Hall E, Rome K, Scaglione M, Eggert J, Au-Yeung B, Wallace DC, Mesaros C, Baur JA, Bailis W. Sci Immunol. 2024 Mar 15;9(93):eadj7238. doi: 10.1126/sciimmunol.adj7238. Epub 2024 Mar 15. PMID: 38489349
Mitochondrial ATP generation is more proteome efficient than glycolysis. Shen Y, Dinh HV, Cruz ER, Chen Z, Bartman CR, Xiao T, Call CM, Ryseck RP, Pratas J, Weilandt D, Baron H, Subramanian A, Fatma Z, Wu ZY, Dwaraknath S, Hendry JI, Tran VG, Yang L, Yoshikuni Y, Zhao H, Maranas CD, Wühr M, Rabinowitz JD. Nat Chem Biol. 2024 Mar 6. doi: 10.1038/s41589-024-01571-y. Online ahead of print. PMID: 38448734
Mapping human hematopoiesis. Bernt KM. Nat Immunol. 2024 Mar 21. doi: 10.1038/s41590-024-01793-1. Online ahead of print. PMID: 38514889
Neoadjuvant chemo-immunotherapy is improved with a novel pulsed electric field technology in an immune-cold murine model. Pastori C, Nafie EHO, Wagh MS, Hunt SJ, Neal RE 2nd. PLoS One. 2024 Mar 25;19(3):e0299499. doi: 10.1371/journal.pone.0299499. eCollection 2024. PMID: 38527041
Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results. Bagley SJ, Logun M, Fraietta JA, Wang X, Desai AS, Bagley LJ, Nabavizadeh A, Jarocha D, Martins R, Maloney E, Lledo L, Stein C, Marshall A, Leskowitz R, Jadlowsky JK, Christensen S, Oner BS, Plesa G, Brennan A, Gonzalez V, Chen F, Sun Y, Gladney W, Barrett D, Nasrallah MP, Hwang WT, Ming GL, Song H, Siegel DL, June CH, Hexner EO, Binder ZA, O'Rourke DM. Nat Med. 2024 Mar 13. doi: 10.1038/s41591-024-02893-z. Online ahead of print. PMID: 38480922
Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α . Roselle C, Horikawa I, Chen L, Kelly AR, Gonzales D, Da T, Wellhausen N, Rommel PC, Baker D, Suhoski M, Scholler J, O'Connor RS, Young RM, Harris CC, June CH. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2317735121. doi: 10.1073/pnas.2317735121. Epub 2024 Feb 26. PMID: 38408246
Charting a course for precision therapy trials in sepsis. Lindell RB, Meyer NJ. Lancet Respir Med. 2024 Mar 11:S2213-2600(24)00070-5. doi: 10.1016/S2213-2600(24)00070-5. Online ahead of print. PMID: 38484747
ALK upregulates POSTN and WNT signaling to drive neuroblastoma. Huang M, Fang W, Farrel A, Li L, Chronopoulos A, Nasholm N, Cheng B, Zheng T, Yoda H, Barata MJ, Porras T, Miller ML, Zhen Q, Ghiglieri L, McHenry L, Wang L, Asgharzadeh S, Park J, Gustafson WC, Matthay KK, Maris JM, Weiss WA. Cell Rep. 2024 Mar 5;43(3):113927. doi: 10.1016/j.celrep.2024.113927. Online ahead of print. PMID: 38451815
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells. Board NL, Yuan Z, Wu F, Moskovljevic M, Ravi M, Sengupta S, Mun SS, Simonetti FR, Lai J, Tebas P, Lynn K, Hoh R, Deeks SG, Siliciano JD, Montaner LJ, Siliciano RF. Nat Immunol. 2024 Mar;25(3):462-470. doi: 10.1038/s41590-023-01741-5. Epub 2024 Jan 26. PMID: 38278966
CRL4b Inhibition Ameliorates Experimental Autoimmune Encephalomyelitis Progression. Dar AA, Ortega Y, Aktas S, Wu K, Guha I, Porter N, Rosen S, DeVita RJ, Pan ZQ, Oliver PM. J Immunol. 2024 Mar 15;212(6):982-991. doi: 10.4049/jimmunol.2300754. PMID: 38265261
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination. Fumagalli V, Ravà M, Marotta D, Di Lucia P, Bono EB, Giustini L, De Leo F, Casalgrandi M, Monteleone E, Mouro V, Malpighi C, Perucchini C, Grillo M, De Palma S, Donnici L, Marchese S, Conti M, Muramatsu H, Perlman S, Pardi N, Kuka M, De Francesco R, Bianchi ME, Guidotti LG, Iannacone M. Nat Immunol. 2024 Mar 14. doi: 10.1038/s41590-024-01787-z. Online ahead of print. PMID: 38486021
Enhancing prime editor activity by directed protein evolution in yeast. Weber Y, Böck D, Ivașcu A, Mathis N, Rothgangl T, Ioannidi EI, Blaudt AC, Tidecks L, Vadovics M, Muramatsu H, Reichmuth A, Marquart KF, Kissling L, Pardi N, Jinek M, Schwank G. Nat Commun. 2024 Mar 7;15(1):2092. doi: 10.1038/s41467-024-46107-z. PMID: 38453904
Common variable immunodeficiency, cross currents, and prevailing winds. Romberg N, Le Coz C. Immunol Rev. 2024 Mar;322(1):233-243. doi: 10.1111/imr.13291. Epub 2023 Nov 28. PMID: 38014621
A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer. Brown BA, Myers PJ, Adair SJ, Pitarresi JR, Sah-Teli SK, Campbell LA, Hart WS, Barbeau MC, Leong K, Seyler N, Kane W, Lee KE, Stelow E, Jones M, Simon MC, Koivunen P, Bauer TW, Stanger BZ, Lazzara MJ. Cancer Res. 2024 Mar 12. doi: 10.1158/0008-5472.CAN-22-2945. Online ahead of print. PMID: 38471099
Inflammatory Proteomic Analysis of 22q11.2 Deletion Syndrome. Frusone V, Maurer K, Emanuel BS, McDonald-McGinn D, Sullivan KE. J Clin Immunol. 2024 Mar 15;44(3):82. doi: 10.1007/s10875-024-01689-7. PMID: 38488991
Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity . Kilich G, Perelygina L, Sullivan KE. Immunol Rev. 2024 Mar;322(1):113-137. doi: 10.1111/imr.13290. Epub 2023 Nov 27. PMID: 38009321
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics. Turner L, Van Le TN, Cross E, Queriault C, Knight M, Trihemasava K, Davis J, Schaefer P, Nguyen J, Xu J, Goldspiel B, Hall E, Rome K, Scaglione M, Eggert J, Au-Yeung B, Wallace DC, Mesaros C, Baur JA, Bailis W. Sci Immunol. 2024 Mar 15;9(93):eadj7238. doi: 10.1126/sciimmunol.adj7238. Epub 2024 Mar 15.PMID: 38489349
Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties. Mani S, Garifallou J, Kim SJ, Simoni MK, Huh DD, Gordon SM, Mainigi M. Front Immunol. 2024 Mar 19;15:1364036. doi: 10.3389/fimmu.2024.1364036. eCollection 2024.PMID: 38566989
Circadian regulation of lung repair and regeneration. Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S. JCI Insight. 2024 Mar 8;9(5):e179745. doi: 10.1172/jci.insight.179745.PMID: 38456509
Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae. Hecht AL, Harling LC, Friedman ES, Tanes C, Lee J, Firrman J, Hao F, Tu V, Liu L, Patterson AD, Bittinger K, Goulian M, Wu GD. J Clin Invest. 2024 Mar 21;134(9):e174726. doi: 10.1172/JCI174726.PMID: 38512401

Efficient engineering of human and mouse primary cells using peptide-assisted genome editing . Zhang Z, Baxter AE, Ren D, Qin K, Chen Z, Collins SM, Huang H, Komar CA, Bailer PF, Parker JB, Blobel GA, Kohli RM, Wherry EJ, Berger SL, Shi J. Nat Biotechnol. 2024 Feb;42(2):305-315. doi: 10.1038/s41587-023-01756-1. Epub 2023 Apr 24. PMID: 37095348
Bone marrow plasma cells require P2RX4 to sense extracellular ATP . Ishikawa M, Hasanali ZS, Zhao Y, Das A, Lavaert M, Roman CJ, Londregan J, Allman D, Bhandoola A. Nature. 2024 Feb;626(8001):1102-1107. doi: 10.1038/s41586-024-07047-2. Epub 2024 Feb 14. PMID: 38355795
The conneXion between sex and immune responses . Forsyth KS, Jiwrajka N, Lovell CD, Toothacre NE, Anguera MC. Nat Rev Immunol. 2024 Feb 21. doi: 10.1038/s41577-024-00996-9. Online ahead of print. PMID: 38383754
Ocrelizumab exposure in relapsing-remitting multiple sclerosis: 10-year analysis of the phase 2 randomized clinical trial and its extension. Kappos L, Traboulsee A, Li DKB, Bar-Or A, Barkhof F, Montalban X, Leppert D, Baldinotti A, Schneble HM, Koendgen H, Sauter A, Wang Q, Hauser SL. J Neurol. 2024 Feb;271(2):642-657. doi: 10.1007/s00415-023-11943-4. Epub 2023 Oct 31. PMID: 37906326
The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination . Culberson EJ, Shields KC, Glynn RA, Allyn BM, Hayer KE, Bassing CH. J Immunol. 2024 Feb 15;212(4):534-540. doi: 10.4049/jimmunol.2300623. PMID: 38117277
Locus folding mechanisms determine modes of antigen receptor gene assembly . Allyn BM, Hayer KE, Oyeniran C, Nganga V, Lee K, Mishra B, Sacan A, Oltz EM, Bassing CH. J Exp Med. 2024 Feb 5;221(2):e20230985. doi: 10.1084/jem.20230985. Epub 2024 Jan 8. PMID: 38189780
Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer . Li Y, Chang RB, Stone ML, Delman D, Markowitz K, Xue Y, Coho H, Herrera VM, Li JH, Zhang L, Choi-Bose S, Giannone M, Shin SM, Coyne EM, Hernandez A, Gross NE, Charmsaz S, Ho WJ, Lee JW, Beatty GL. Cell Rep Med. 2024 Feb 20;5(2):101397. doi: 10.1016/j.xcrm.2024.101397. Epub 2024 Feb 1. PMID: 38307029
Synthetic angiotensin II peptide derivatives confer protection against cerebral and severe non-cerebral malaria in murine models. Silva AF, Torres MDT, Silva LS, Alves FL, Miranda A, Oliveira VX Jr, de la Fuente-Nunez C, Pinheiro AAS. Sci Rep. 2024 Feb 26;14(1):4682. doi: 10.1038/s41598-024-51267-5. PMID: 38409185
Psoriasis - More Progress but More Questions . Gelfand JM. N Engl J Med. 2024 Feb 8;390(6):561-562. doi: 10.1056/NEJMe2314345. PMID: 38324492
Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a . Armani-Tourret M, Gao C, Hartana CA, Sun W, Carrere L, Vela L, Hochroth A, Bellefroid M, Sbrolla A, Shea K, Flynn T, Roseto I, Rassadkina Y, Lee C, Giguel F, Malhotra R, Bushman FD, Gandhi RT, Yu XG, Kuritzkes DR, Lichterfeld M.Cell. 2024 Feb 29;187(5):1238-1254.e14. doi: 10.1016/j.cell.2024.01.037. Epub 2024 Feb 17. PMID: 38367616
Diagnostic challenges of the idiopathic plasmacytic lymphadenopathy (IPL) subtype of idiopathic multicentric Castleman disease (iMCD): Factors to differentiate from IgG4-related disease. Nishikori A, Nishimura MF, Fajgenbaum DC, Nishimura Y, Maehama K, Haratake T, Tabata T, Kawano M, Nakamura N, Momose S, Sumiyoshi R, Koga T, Yamamoto H, van Rhee F, Kawakami A, Sato Y. J Clin Pathol. 2024 Feb 20:jcp-2023-209280. doi: 10.1136/jcp-2023-209280. Online ahead of print. PMID: 38378248
Incident Asthma, Asthma Exacerbations, and Asthma-Related Hospitalizations in Patients With Atopic Dermatitis. Wan J, Wang S, Shin DB, Syed MN, Abuabara K, Lemeshow AR, Gelfand JM. J Allergy Clin Immunol Pract. 2024 Feb;12(2):421-430.e1. doi: 10.1016/j.jaip.2023.11.009. Epub 2023 Nov 14. PMID: 37972919
RALDH1 Inhibition Shows Immunotherapeutic Efficacy in Hepatocellular Carcinoma . Yu P, Cao S, Yang SM, Rai G, Martinez NJ, Yasgar A, Zakharov AV, Simeonov A, Molina Arocho WA, Lobel GP, Mohei H, Scott AL, Zhai L, Furth EE, Simon MC, Haldar M. Cancer Immunol Res. 2024 Feb 2;12(2):180-194. doi: 10.1158/2326-6066.CIR-22-1023. PMID: 38051215
Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential. Hamley M, Leyk S, Casar C, Liebold I, Jawazneh AA, Lanzloth C, Böttcher M, Haas H, Richardt U, Rothlin CV, Jacobs T, Huber S, Adlung L, Pelczar P, Henao-Mejia J, Bosurgi L. Eur J Immunol. 2024 Feb;54(2):e2350434. doi: 10.1002/eji.202350434. Epub 2023 Nov 28. PMID: 37971166
Immunity to Cryptosporidium: insights into principles of enteric responses to infection . Pardy RD, Wallbank BA, Striepen B, Hunter CA. Nat Rev Immunol. 2024 Feb;24(2):142-155. doi: 10.1038/s41577-023-00932-3. Epub 2023 Sep 11. PMID: 37697084
ZFP36 disruption is insufficient to enhance the function of mesothelin-targeting human CAR-T cells . Mai D, Boyce T, Mehta A, Reff J, Scholler J, Sheppard NC, June CH. Sci Rep. 2024 Feb 7;14(1):3113. doi: 10.1038/s41598-024-53769-8. PMID: 38326511
Unanswered questions following reports of secondary malignancies after CAR-T cell therapy . Levine BL, Pasquini MC, Connolly JE, Porter DL, Gustafson MP, Boelens JJ, Horwitz EM, Grupp SA, Maus MV, Locke FL, Ciceri F, Ruggeri A, Snowden J, Heslop HE, Mackall CL, June CH, Sureda AM, Perales MA. Nat Med. 2024 Feb;30(2):338-341. doi: 10.1038/s41591-023-02767-w. PMID: 38195751
Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation. Lo Faro V, Bhattacharya A, Zhou W, Zhou D, Wang Y, Läll K, Kanai M, Lopera-Maya E, Straub P, Pawar P, Tao R, Zhong X, Namba S; Global Biobank Meta-analysis Initiative; Sanna S, Nolte IM, Okada Y, Ingold N, MacGregor S, Snieder H, Surakka I, Shortt J, Gignoux C, Rafaels N, Crooks K, Verma A, Verma SS, Guare L, Rader DJ, Willer C, Martin AR, Brantley MA Jr, Gamazon ER, Jansonius NM, Joos K, Cox NJ, Hirbo J. Cell Rep Med. 2024 Feb 20;5(2):101430. doi: 10.1016/j.xcrm.2024.101430. PMID: 38382466
Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity . Katsuda T, Sussman JH, Ito K, Katznelson A, Yuan S, Takenaka N, Li J, Merrell AJ, Cure H, Li Q, Rasool RU, Asangani IA, Zaret KS, Stanger BZ. Nat Commun. 2024 Feb 26;15(1):1761. doi: 10.1038/s41467-024-45939-z. PMID: 38409161
Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma . Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH, Stanger BZ. Nat Commun. 2024 Feb 20;15(1):1532. doi: 10.1038/s41467-024-46048-7. PMID: 38378697
Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans. Feng Y, Xie N, Inoue F, Fan S, Saskin J, Zhang C, Zhang F, Hansen MEB, Nyambo T, Mpoloka SW, Mokone GG, Fokunang C, Belay G, Njamnshi AK, Marks MS, Oancea E, Ahituv N, Tishkoff SA. Nat Genet. 2024 Feb;56(2):258-272. doi: 10.1038/s41588-023-01626-1. Epub 2024 Jan 10. PMID: 38200130
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models . Xue L, Hamilton AG, Zhao G, Xiao Z, El-Mayta R, Han X, Gong N, Xiong X, Xu J, Figueroa-Espada CG, Shepherd SJ, Mukalel AJ, Alameh MG, Cui J, Wang K, Vaughan AE, Weissman D, Mitchell MJ. Nat Commun. 2024 Feb 29;15(1):1884. doi: 10.1038/s41467-024-45422-9. PMID: 38424061
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Han X, Xu J, Xu Y, Alameh MG, Xue L, Gong N, El-Mayta R, Palanki R, Warzecha CC, Zhao G, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ. Nat Commun. 2024 Feb 26;15(1):1762. doi: 10.1038/s41467-024-45537-z. PMID: 38409275
Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery . Zhao G, Xue L, Geisler HC, Xu J, Li X, Mitchell MJ, Vaughan AE. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2314747121. doi: 10.1073/pnas.2314747121. Epub 2024 Feb 5. PMID: 38315853
Machine learning links T-cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer. Blise KE, Sivagnanam S, Betts CB, Betre K, Kirchberger N, Tate BJ, Furth EE, Dias Costa A, Nowak JA, Wolpin BM, Vonderheide RH, Goecks J, Coussens LM, Byrne KT. Cancer Immunol Res. 2024 Feb 21. doi: 10.1158/2326-6066.CIR-23-0873. Online ahead of print. PMID: 38381401
Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma. Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH, Stanger BZ. Nat Commun. 2024 Feb 20;15(1):1532. doi: 10.1038/s41467-024-46048-7. PMID: 38378697
Unsupervised and supervised discovery of tissue cellular neighborhoods from cell phenotypes. Hu Y, Rong J, Xu Y, Xie R, Peng J, Gao L, Tan K. Nat Methods. 2024 Feb;21(2):267-278. doi: 10.1038/s41592-023-02124-2. Epub 2024 Jan 8. PMID: 38191930
Bile salt hydrolase catalyses formation of amine-conjugated bile acids . Rimal B, Collins SL, Tanes CE, Rocha ER, Granda MA, Solanki S, Hoque NJ, Gentry EC, Koo I, Reilly ER, Hao F, Paudel D, Singh V, Yan T, Kim MS, Bittinger K, Zackular JP, Krausz KW, Desai D, Amin S, Coleman JP, Shah YM, Bisanz JE, Gonzalez FJ, Vanden Heuvel JP, Wu GD, Zemel BS, Dorrestein PC, Weinert EE, Patterson AD. Nature. 2024 Feb;626(8000):859-863. doi: 10.1038/s41586-023-06990-w. Epub 2024 Feb 7. PMID: 38326609

Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial . Bagley SJ, Binder ZA, Lamrani L, Marinari E, Desai AS, Nasrallah MP, Maloney E, Brem S, Lustig RA, Kurtz G, Alonso-Basanta M, Bonté PE, Goudot C, Richer W, Piaggio E, Kothari S, Guyonnet L, Guerin CL, Waterfall JJ, Mohan S, Hwang WT, Tang OY, Logun M, Bhattacharyya M, Markowitz K, Delman D, Marshall A, Wherry EJ, Amigorena S, Beatty GL, Brogdon JL, Hexner E, Migliorini D, Alanio C, O'Rourke DM. Nat Cancer. 2024 Jan 12. doi: 10.1038/s43018-023-00709-6. Online ahead of print. PMID: 38216766
CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn. Albelda SM. Nat Rev Clin Oncol. 2024 Jan;21(1):47-66. doi: 10.1038/s41571-023-00832-4. Epub 2023 Oct 30. PMID: 37904019
The Underlying Rab Network of MRGPRX2-Stimulated Secretion Unveils the Impact of Receptor Trafficking on Secretory Granule Biogenesis and Secretion . Lazki-Hagenbach P, Kleeblatt E, Fukuda M, Ali H, Sagi-Eisenberg R. Cells. 2024 Jan 1;13(1):93. doi: 10.3390/cells13010093. PMID: 38201297
S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes . Dixit D, Hallisey VM, Zhu EY, Okuniewska M, Cadwell K, Chipuk JE, Axelrad JE, Schwab SR. J Clin Invest. 2024 Jan 9;134(4):e174984. doi: 10.1172/JCI174984. PMID: 38194271
Cytokine signature in convalescent SARS-CoV-2 patients with inflammatory bowel disease receiving vedolizumab. Dallari S, Martinez Pazos V, Munoz Eusse J, Wellens J, Thompson C, Colombel JF, Satsangi J, Cadwell K, Wong SY; ICARUS-IBD Working Group. Sci Rep. 2024 Jan 2;14(1):186. doi: 10.1038/s41598-023-50035-1. PMID: 38168138
Beyond antiviral: Interferon induced by bacteria maintains tolerance in the gut. Yang Y, Cadwell K. J Exp Med. 2024 Jan 1;221(1):e20232011. doi: 10.1084/jem.20232011. Epub 2023 Dec 13. PMID: 38091026
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue . Zhao G, Xue L, Weiner AI, Gong N, Adams-Tzivelekidis S, Wong J, Gentile ME, Nottingham AN, Basil MC, Lin SM, Niethamer TK, Diamond JM, Bermudez CA, Cantu E, Han X, Cao Y, Alameh MG, Weissman D, Morrisey EE, Mitchell MJ, Vaughan AE. Sci Transl Med. 2024 Jan 31;16(732):eadg6229. doi: 10.1126/scitranslmed.adg6229. Epub 2024 Jan 31. PMID: 38295183
Facts and hopes in immunotherapy strategies targeting antigens derived from KRAS mutations . Linette GP, Bear AS, Carreno BM. Clin Cancer Res. 2024 Jan 24. doi: 10.1158/1078-0432.CCR-23-1212. Online ahead of print. PMID: 38266167
Acute hospitalizations after proton therapy versus intensity-modulated radiotherapy for locally advanced non-small cell lung cancer in the durvalumab era . Iocolano M, Yegya-Raman N, Friedes C, Wang X, Kegelman T, Lee SH, Duan L, Li B, Levin WP, Cengel KA, Konski A, Langer CJ, Cohen RB, Sun L, Aggarwal C, Doucette A, Xiao Y, Kevin Teo BK, O'Reilly S, Zou W, Bradley JD, Simone CB 2nd, Feigenberg SJ. Cancer. 2024 Jan 31. doi: 10.1002/cncr.35230. Online ahead of print. PMID: 38294959
MARS an improved de novo peptide candidate selection method for non-canonical antigen target discovery in cancer. Liao H, Barra C, Zhou Z, Peng X, Woodhouse I, Tailor A, Parker R, Carré A, Borrow P, Hogan MJ, Paes W, Eisenlohr LC, Mallone R, Nielsen M, Ternette N. Nat Commun. 2024 Jan 22;15(1):661. doi: 10.1038/s41467-023-44460-z. PMID: 38253617
Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy. Zhang D, Cleveland AH, Krimitza E, Han K, Yi C, Stout AL, Zou W, Dorsey JF, Gong Y, Fan Y. Nat Protoc. 2024 Jan 11. doi: 10.1038/s41596-023-00941-5. Online ahead of print. PMID: 38212641
FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced Melanoma . Anderson TM, Chang BH, Huang AC, Xu X, Yoon D, Shang CG, Mick R, Schubert E, McGettigan S, Kreider K, Xu W, Wherry EJ, Schuchter LM, Amaravadi RK, Mitchell TC, Farwell MD. Clin Cancer Res. 2024 Jan 24:OF1-OF10. doi: 10.1158/1078-0432.CCR-23-2390. Online ahead of print. PMID: 38263597
Human tumor-associated macrophages and neutrophils regulate anti-tumor antibody efficacy through lethal and sublethal trogocytosis . Singhal S, Rao AS, Stadanlick J, Bruns K, Sullivan NT, Bermudez A, Honig-Frand A, Krouse R, Arambepola S, Guo E, Moon EK, Georgiou G, Valerius T, Albelda SM, Eruslanov EB. Cancer Res. 2024 Jan 25. doi: 10.1158/0008-5472.CAN-23-2135. Online ahead of print. PMID: 38270915
T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy. Ghilardi G, Fraietta JA, Gerson JN, Van Deerlin VM, Morrissette JJD, Caponetti GC, Paruzzo L, Harris JC, Chong EA, Susanibar Adaniya SP, Svoboda J, Nasta SD, Ugwuanyi OH, Landsburg DJ, Fardella E, Waxman AJ, Chong ER, Patel V, Pajarillo R, Kulikovskaya I, Lieberman DB, Cohen AD, Levine BL, Stadtmauer EA, Frey NV, Vogl DT, Hexner EO, Barta SK, Porter DL, Garfall AL, Schuster SJ, June CH, Ruella M. Nat Med. 2024 Jan 24. doi: 10.1038/s41591-024-02826-w. Online ahead of print. PMID: 38266761
Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies . Medina-Munoz HC, Kofman E, Jagannatha P, Boyle EA, Yu T, Jones KL, Mueller JR, Lykins GD, Doudna AT, Park SS, Blue SM, Ranzau BL, Kohli RM, Komor AC, Yeo GW. Nat Commun. 2024 Jan 29;15(1):875. doi: 10.1038/s41467-024-45009-4. PMID: 38287010
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation. Haque TT, Weissler KA, Schmiechen Z, Laky K, Schwartz DM, Li J, Locci M, Turfkruyer M, Yao C, Schaughency P, Leak L, Lack J, Kanno Y, O'Shea J, Frischmeyer-Guerrerio PA. Sci Immunol. 2024 Jan 19;9(91):eadg8691. doi: 10.1126/sciimmunol.adg8691. Epub 2024 Jan 19. PMID: 38241399
mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis . Matias J, Cui Y, Lynn GE, DePonte K, Mesquita E, Muramatsu H, Alameh MG, Dwivedi G, Tam YK, Pardi N, Weissman D, Fikrig E. Sci Rep. 2024 Jan 4;14(1):496. doi: 10.1038/s41598-023-50389-6. PMID: 38177212
mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b . Uehara K, Lee WD, Stefkovich M, Biswas D, Santoleri D, Garcia Whitlock AE, Quinn Iii WJ, Coopersmith TN, Creasy KT, Rader DJ, Sakamoto K, Rabinowitz JD, Titchenell PM. J Clin Invest. 2024 Jan 30:e173782. doi: 10.1172/JCI173782. Online ahead of print. PMID: 38290087
Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis . Song I, Thompson EW, Verma A, MacLean MT, Duda J, Elahi A, Tran R, Raghupathy P, Swago S, Hazim M, Bhattaru A, Schneider C, Vujkovic M, Torigian DA, Kahn CE, Gee JC, Borthakur A, Kripke CM, Carson CC, Carr R, Jehangir Q, Ko YA, Litt H, Rosen M, Mankoff DA, Schnall MD, Shou H, Chirinos J, Damrauer SM, Serper M, Chen J, Rader DJ; Penn Medicine BioBank; Witschey WRT, Sagreiya H. Sci Rep. 2024 Jan 2;14(1):53. doi: 10.1038/s41598-023-49470-x. PMID: 38167550
Antibodies targeting the fusion peptide on the HIV envelope provide protection to rhesus macaques against mucosal SHIV challenge. Pegu A, Lovelace SE, DeMouth ME, Cully MD, Morris DJ, Li Y, Wang K, Schmidt SD, Choe M, Liu C, Chen X, Viox E, Rowshan A, Taft JD, Zhang B, Xu K, Duan H, Ou L, Todd JP, Kong R, Li H, Shaw GM, Doria-Rose NA, Kwong PD, Koup RA, Mascola JR. Sci Transl Med. 2024 Jan 17;16(730):eadh9039. doi: 10.1126/scitranslmed.adh9039. Epub 2024 Jan 17. PMID: 38232141
Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection. Frumento N, Sinnis-Bourozikas A, Paul HT, Stavrakis G, Zahid MN, Wang S, Ray SC, Flyak AI, Shaw GM, Cox AL, Bailey JR. Immunity. 2024 Jan 9;57(1):40-51.e5. doi: 10.1016/j.immuni.2023.12.004. Epub 2024 Jan 2. PMID: 38171362
Sustained rhoptry docking and discharge requires Toxoplasma gondii intraconoidal microtubule-associated proteins . Dos Santos Pacheco N, Tell I Puig A, Guérin A, Martinez M, Maco B, Tosetti N, Delgado-Betancourt E, Lunghi M, Striepen B, Chang YW, Soldati-Favre D. Nat Commun. 2024 Jan 9;15(1):379. doi: 10.1038/s41467-023-44631-y. PMID: 38191574
Genetic crosses within and between species of Cryptosporidium. Shaw S, Cohn IS, Baptista RP, Xia G, Melillo B, Agyabeng-Dadzie F, Kissinger JC, Striepen B. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2313210120. doi: 10.1073/pnas.2313210120. Epub 2023 Dec 26. PMID: 38147547
Reversible synaptic adaptations in a subpopulation of murine hippocampal neurons following early-life seizures . Xing B, Barbour AJ, Vithayathil J, Li X, Dutko S, Fawcett-Patel J, Lancaster E, Talos DM, Jensen FE. J Clin Invest. 2024 Jan 16;134(5):e175167. doi: 10.1172/JCI175167. PMID: 38227384

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