Publications

High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline. Wang G, Lyudovyk O, Kim JY, Lin YH, Elhanati Y, Mathew D, Wherry EJ, Herati RS, Greenplate AR, Greenbaum B, Vardhana SA, Huang AC. STAR Protoc. 2023 May 8;4(2):102289. doi: 10.1016/j.xpro.2023.102289. Online ahead of print. PMID: 37159385
CD38 as a pan-hematologic target for chimeric antigen receptor T cells. Glisovic-Aplenc T, Diorio C, Chukinas JA, Veliz K, Shestova O, Shen F, Nunez-Cruz S, Vincent TL, Miao F, Milone MC, June CH, Teachey DT, Tasian SK, Aplenc R, Gill SI. Blood Adv. 2023 May 12:bloodadvances.2022007059. doi: 10.1182/bloodadvances.2022007059. Online ahead of print. PMID: 37171449
TLR priming licenses NAIP inflammasome activation by immunoevasive ligands. Grayczyk JP, Egan MS, Liu L, Aunins E, Wynosky-Dolfi MA, Canna S, Minn AJ, Shin S, Brodsky IE. bioRxiv. 2023 May 4:2023.05.04.539437. doi: 10.1101/2023.05.04.539437. Preprint. PMID: 37205371
Dexamethasone and Statins in Patients Undergoing Primary Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Propensity-Matched Study in the TriNetX Research Network. Sioutas GS, Mannam SS, Tarbay AC, Nia AM, Salem MM, Vivanco-Suarez J, Burkhardt JK, Jankowitz BT, Srinivasan VM. World Neurosurg. 2023 May 8:S1878-8750(23)00611-3. doi: 10.1016/j.wneu.2023.04.127. Online ahead of print. PMID: 37164211
Safety and efficacy of the Pipeline Flex embolization device with Shield Technology for the acute treatment of ruptured internal carotid artery pseudoaneurysms: a multi-institution case series. Bounajem MT, Joyce E, Scoville JP, Seinfeld J, Hoffman J, Grossberg JA, Waiters V, White AC, Nerva J, Burkhardt JK, Tonetti DA, El Naamani K, Gooch MR, Jabbour P, Tjoumakaris S, Ortega Gutierrez S, Levitt MR, Lang M, Ares WJ, Desai S, Mascitelli JR, Kilburg CJ, Budohoski KP, Couldwell WT, Gross BA, Grandhi R. Neurosurg Focus. 2023 May;54(5):E4. doi: 10.3171/2023.2.FOCUS233. PMID: 37127036
Safety and efficacy of the p48 MW and p64 flow modulation devices: a systematic review and meta-analysis. Vivanco-Suarez J, Salem MM, Sioutas GS, Covell MM, Jankowitz BT, Srinivasan VM, Burkhardt JK. Neurosurg Focus. 2023 May;54(5):E7. doi: 10.3171/2023.2.FOCUS22648. PMID: 37127026
Sexual dimorphism in the response to chronic circadian misalignment on a high-fat diet. Anderson ST, Meng H, Brooks TG, Tang SY, Lordan R, Sengupta A, Nayak S, Mřela A, Sarantopoulou D, Lahens NF, Weljie A, Grant GR, Bushman FD, FitzGerald GA. Sci Transl Med. 2023 May 17;15(696):eabo2022. doi: 10.1126/scitranslmed.abo2022. Epub 2023 May 17. PMID: 37196066

In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40. Wu JE, Manne S, Ngiow SF, Baxter AE, Huang H, Freilich E, Clark ML, Lee JH, Chen Z, Khan O, Staupe RP, Huang YJ, Shi J, Giles JR, Wherry EJ. bioRxiv. 2023 Apr 17:2023.04.17.537229. doi: 10.1101/2023.04.17.537229. Preprint. PMID: 37131713
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing. Zhang Z, Baxter AE, Ren D, Qin K, Chen Z, Collins SM, Huang H, Komar CA, Bailer PF, Parker JB, Blobel GA, Kohli RM, Wherry EJ, Berger SL, Shi J. Nat Biotechnol. 2023 Apr 24. doi: 10.1038/s41587-023-01756-1. Online ahead of print. PMID: 37095348
Human T follicular helper clones seed the germinal center-resident regulatory pool. Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, Wherry EJ, Gonzalez M, Romberg N. Sci Immunol. 2023 Apr 14;8(82):eade8162. doi: 10.1126/sciimmunol.ade8162. Epub 2023 Apr 7. PMID: 37027481
Tumor-derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors. Zhong W, Xiao Z, Qin Z, Yang J, Wen Y, Yu Z, Li Y, Sheppard NC, Fuchs SY, Xu X, Herlyn M, June CH, Pure E, Guo W. Cancer Res. 2023 Apr 28:CAN-22-2220. doi: 10.1158/0008-5472.CAN-22-2220. Online ahead of print. PMID: 37115855
Disruption of desmoplastic stroma overcomes restrictions to T cell extravasation, immune exclusion and immunosuppression in solid tumors. Xiao Z, Lu Z, Todd L, Huang L, Kopp M, Huang L, Zhong W, Li Y, Guo W, Scholler J, June CH, Albelda SM, Pur E. bioRxiv. 2023 Apr 16:2023.04.13.536777. doi: 10.1101/2023.04.13.536777. Preprint. PMID: 37090547
Identifying highly active anti-CCR4-CAR T cells for the treatment of T-cell lymphoma. Watanabe K, Aznar MA, Kuramitsu S, Siurala M, Da T, Agarwal S, Song D, Scholler J, Rotolo A, Posey AD, Rook AH, Haun PL, Ruella M, Young RM, June CH. Blood Adv. 2023 Apr 14:bloodadvances.2022008327. doi: 10.1182/bloodadvances.2022008327. Online ahead of print. PMID: 37058474
A model for crowdsourcing high-impact research questions for Castleman disease and other rare diseases. Korsunska A, Repasky M, Zuccato M, Fajgenbaum DC. Orphanet J Rare Dis. 2023 Apr 11;18(1):75. doi: 10.1186/s13023-023-02678-6. PMID: 37041585
Dev elopment of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus. Furey C, Ye N, Kercher L, DeBeauchamp J, Crumpton JC, Jeevan T, Patton C, Franks J, Alameh MG, Fan SHY, Phan AT, Hunter CA, Webby RJ, Weissman D, Hensley SE. bioRxiv. 2023 Apr 30:2023.04.30.538854. doi: 10.1101/2023.04.30.538854. Preprint. PMID: 37162920
Improved eukaryotic detection compatible with large-scale automated analysis of metagenomes . Bazant W, Blevins AS, Crouch K, Beiting DP. Microbiome. 2023 Apr 10;11(1):72. doi: 10.1186/s40168-023-01505-1. PMID: 37032329
Inflammatory monocytes promote granuloma control of Yersinia infection. Sorobetea D, Matsuda R, Peterson ST, Grayczyk JP, Rao I, Krespan E, Lanza M, Assenmacher CA, Mack M, Beiting DP, Radaelli E, Brodsky IE. Nat Microbiol. 2023 Apr;8(4):666-678. doi: 10.1038/s41564-023-01338-6. Epub 2023 Mar 6. PMID: 36879169
Genetic Ablation of a Female-Specific Apetala 2 Transcription Factor Blocks Oocyst Shedding in Cryptosporidium parvum. Tandel J, Walzer KA, Byerly JH, Pinkston B, Beiting DP, Striepen B. mBio. 2023 Apr 25;14(2):e0326122. doi: 10.1128/mbio.03261-22. Epub 2023 Feb 14. PMID: 36786597
Genome folding dynamics during the M-to-G1-phase transition . Zhang H, Blobel GA. Curr Opin Genet Dev. 2023 Apr 24;80:102036. doi: 10.1016/j.gde.2023.102036. Online ahead of print. PMID: 37099832
A TNF-IL-1 circuit controls Yersinia within intestinal granulomas. Matsuda R, Sorobetea D, Zhang J, Peterson ST, Grayczyk JP, Herrmann B, Yost W, O'Neill R, Bohrer AC, Lanza M, Assenmacher CA, Mayer-Barber KD, Shin S, Brodsky IE. bioRxiv. 2023 Apr 22:2023.04.21.537749. doi: 10.1101/2023.04.21.537749. Preprint. PMID: 37197029
Arresting microbiome development limits immune system maturation and resistance to infection in mice. Lubin JB, Green J, Maddux S, Denu L, Duranova T, Lanza M, Wynosky-Dolfi M, Flores JN, Grimes LP, Brodsky IE, Planet PJ, Silverman MA. Cell Host Microbe. 2023 Apr 12;31(4):554-570.e7. doi: 10.1016/j.chom.2023.03.006. Epub 2023 Mar 29. PMID: 36996818
Commentary: Twenty Years, 10 Fellows, 1 Article: Reflections on Cerebrovascular Training and the Evolution of Basilar Apex Aneurysm Treatments. Graffeo CS, Srinivasan VM, Frisoli F, Lang MJ, Mascitelli JR, Burkhardt JK, Walcott BP, Owen CM, Rodriguez-Hernandez A, Abla AA. Neurosurgery. 2023 Apr 19. doi: 10.1227/neu.0000000000002500. Online ahead of print. PMID: 37074050
Crosstalk between skin microbiota and immune system in health and disease. Liu Q, Ranallo R, Rios C, Grice EA, Moon K, Gallo RL. Nat Immunol. 2023 Apr 20. doi: 10.1038/s41590-023-01500-6. Online ahead of print. PMID: 37081151
A miRNA/CXCR4 signaling axis impairs monopoiesis and angiogenesis in diabetic critical limb ischemia . Cheng HS, Zhuang R, Pérez-Cremades D, Chen J, Jamaiyar A, Wu W, Sausen G, Tzani A, Plutzky J, Henao-Mejia J, Goodney PP, Creager MA, Sabatine MS, Bonaca MP, Feinberg MW. JCI Insight. 2023 Apr 10;8(7):e163360. doi: 10.1172/jci.insight.163360. PMID: 36821386

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. Tsuchida CA, Brandes N, Bueno R, Trinidad M, Mazumder T, Yu B, Hwang B, Chang C, Liu J, Sun Y, Hopkins CR, Parker KR, Qi Y, Satpathy AT, Stadtmauer EA, Cate JHD, Eyquem J, Fraietta JA, June CH, Chang HY, Ye CJ, Doudna JA. bioRxiv. 2023 Mar 22:2023.03.22.533709. doi: 10.1101/2023.03.22.533709. Preprint.PMID: 36993359
Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells. Mai D, Johnson O, Reff J, Fan TJ, Scholler J, Sheppard NC, June CH. Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2218632120. doi: 10.1073/pnas.2218632120. Epub 2023 Mar 15. PMID: 36920923
Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies. Pilling OA, Reis-Cunha JL, Grace CA, Berry ASF, Mitchell MW, Yu JA, Malekshahi CR, Krespan E, Go CK, Lombana C, Song YS, Amorim CF, Lago AS, Carvalho LP, Carvalho EM, Brisson D, Scott P, Jeffares DC, Beiting DP. PLoS Pathog. 2023 Mar 20;19(3):e1011230. doi: 10.1371/journal.ppat.1011230. eCollection 2023 Mar. PMID: 36940219
Multivariate indicators of disease severity in COVID-19. Bean J, Kuri-Cervantes L, Pennella M, Betts MR, Meyer NJ, Hassan WM. Sci Rep. 2023 Mar 29;13(1):5145. doi: 10.1038/s41598-023-31683-9. PMID: 36991002
COVID-19 Self-Testing Preferences Linked to Political Perspectives: Social Determinants in the U.S. Pandemic. Fishman J, Bien-Gund CH, Bisson GP, Baik Y. Am J Prev Med. 2023 Mar;64(3):438-440. doi: 10.1016/j.amepre.2022.09.024. Epub 2022 Nov 3. PMID: 36411144
Molecular basis of polycomb group protein-mediated fetal hemoglobin repression. Qin K, Lan X, Huang P, Saari MS, Khandros E, Keller CA, Giardine BM, Abdulmalik O, Shi J, Hardison RC, Blobel GA. Blood. 2023 Mar 9:blood.2022019578. doi: 10.1182/blood.2022019578. Online ahead of print. PMID: 36893455
Gene silencing dynamics are modulated by transiently active regulatory elements. Vermunt MW, Luan J, Zhang Z, Thrasher AJ, Huang A, Saari MS, Khandros E, Beagrie RA, Zhang S, Vemulamada P, Brilleman M, Lee K, Yano JA, Giardine BM, Keller CA, Hardison RC, Blobel GA. Mol Cell. 2023 Mar 2;83(5):715-730.e6. doi: 10.1016/j.molcel.2023.02.006. PMID: 36868189
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate. Shiraishi K, Shah PP, Morley MP, Loebel C, Santini GT, Katzen J, Basil MC, Lin SM, Planer JD, Cantu E, Jones DL, Nottingham AN, Li S, Cardenas-Diaz FL, Zhou S, Burdick JA, Jain R, Morrisey EE. Cell. 2023 Mar 30;186(7):1478-1492.e15. doi: 10.1016/j.cell.2023.02.010. Epub 2023 Mar 3. PMID: 36870331
Harnessing imaging tools to guide immunotherapy trials: summary from the National Cancer Institute Cancer Imaging Steering Committee workshop. Shankar LK, Schöder H, Sharon E, Wolchok J, Knopp MV, Wahl RL, Ellingson BM, Hall NC, Yaffe MJ, Towbin AJ, Farwell MD, Pryma D, Poussaint TY, Wright CL, Schwartz L, Harisinghani M, Mahmood U, Wu AM, Leung D, de Vries EGE, Tang Y, Beach G, Reeves SA. Lancet Oncol. 2023 Mar;24(3):e133-e143. doi: 10.1016/S1470-2045(22)00742-2. PMID: 36858729
HIV post-treatment controllers have distinct immunological and virological features. Etemad B, Sun X, Li Y, Melberg M, Moisi D, Gottlieb R, Ahmed H, Aga E, Bosch RJ, Acosta EP, Yuki Y, Martin MP, Carrington M, Gandhi RT, Jacobson JM, Volberding P, Connick E, Mitsuyasu R, Frank I, Saag M, Eron JJ, Skiest D, Margolis DM, Havlir D, Schooley RT, Lederman MM, Yu XG, Li JZ. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218960120. doi: 10.1073/pnas.2218960120. Epub 2023 Mar 6. PMID: 36877848
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation. Ko KI, DerGarabedian BP, Chen Z, Debnath R, Ko A, Link BN, Korostoff JM, Graves DT. J Exp Med. 2023 Mar 6;220(3):e20221350. doi: 10.1084/jem.20221350. Epub 2022 Dec 30. PMID: 36584405
Clinical Outcomes Associated With Pembrolizumab Monotherapy Among Adults With Diffuse Malignant Peritoneal Mesothelioma. Marmarelis ME, Wang X, Roshkovan L, Grady CB, Miura JT, Ginsberg MS, Ciunci CA, Egger J, Walker S, Cercek A, Foote MB, Litzky LA, Nash G, Haas AR, Karakousis GC, Cengel KA, Katz SI, Zauderer MG, Langer CJ, Offin M. JAMA Netw Open. 2023 Mar 1;6(3):e232526. doi: 10.1001/jamanetworkopen.2023.2526. PMID: 36897589
IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii. Clark JT, Weizman OE, Aldridge DL, Shallberg LA, Eberhard J, Lanzar Z, Wasche D, Huck JD, Zhou T, Ring AM, Hunter CA. Cell Rep. 2023 Mar 28;42(3):112147. doi: 10.1016/j.celrep.2023.112147. Epub 2023 Feb 23. PMID: 36827187
Immature natural killer cells promote progression of triple-negative breast cancer. Thacker G, Henry S, Nandi A, Debnath R, Singh S, Nayak A, Susnik B, Boone MM, Zhang Q, Kesmodel SB, Gumber S, Das GM, Kambayashi T, Dos Santos CO, Chakrabarti R. Sci Transl Med. 2023 Mar 8;15(686):eabl4414. doi: 10.1126/scitranslmed.abl4414. Epub 2023 Mar 8. PMID: 36888695

MRGPRX2 in drug allergy: What we know and what we do not know. Kolkhir P, Ali H, Babina M, Ebo D, Sabato V, Elst J, Frischbutter S, Pyatilova P, Maurer M. J Allergy Clin Immunol. 2023 Feb;151(2):410-412. doi: 10.1016/j.jaci.2022.09.004. Epub 2022 Sep 9. PMID: 36089079
The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR ⁺CD8 ⁺ effector state and its deletion improves checkpoint blockade. McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. bioRxiv. 2023 Feb 16:2023.02.16.528833. doi: 10.1101/2023.02.16.528833. Preprint. PMID: 36824931
Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies. Painter MM, Johnston TS, Lundgreen KA, Santos JJS, Qin JS, Goel RR, Apostolidis SA, Mathew D, Fulmer B, Williams JC, McKeague ML, Pattekar A, Goode A, Nasta S, Baxter AE, Giles JR, Skelly AN, Felley LE, McLaughlin M, Weaver J; Penn Medicine BioBank; Kuthuru O, Dougherty J, Adamski S, Long S, Kee M, Clendenin C, da Silva Antunes R, Grifoni A, Weiskopf D, Sette A, Huang AC, Rader DJ, Hensley SE, Bates P, Greenplate AR, Wherry EJ. bioRxiv. 2023 Feb 6:2023.02.05.527215. doi: 10.1101/2023.02.05.527215. Preprint.PMID: 36798171
A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease. Brandstadter JD, De Martin A, Lütge M, Ferreira A, Gaudette BT, Stanossek Y, Wang S, Gonzalez MV, Camiolo E, Wertheim G, Austin B, Allman D, Lim MS, Fajgenbaum DC, Aster JC, Ludewig B, Maillard I. bioRxiv. 2023 Feb 7:2023.02.06.525604. doi: 10.1101/2023.02.06.525604. Preprint. PMID: 36798373
Unusual X chromosome inactivation maintenance in female alveolar type 2 cells is correlated with increased numbers of X-linked escape genes and sex-biased gene expression . Sierra I, Pyfrom S, Weiner A, Zhao G, Driscoll A, Yu X, Gregory BD, Vaughan AE, Anguera MC. Stem Cell Reports. 2023 Feb 14;18(2):489-502. doi: 10.1016/j.stemcr.2022.12.005. Epub 2023 Jan 12. PMID: 36638790
Differential CD4+ T-Cell Cytokine and Cytotoxic Responses Between Reactivation and Latent Phases of Herpes Zoster Infection. Jin W, Fang M, Sayin I, Smith C, Hunter JL, Richardson B, Golden JB, Haley C, Schmader KE, Betts MR, Tyring SK, Cameron CM, Cameron MJ, Canaday DH. Pathog Immun. 2023 Feb 17;7(2):171-188. doi: 10.20411/pai.v7i2.560. eCollection 2022. PMID: 36865570
Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4⁺ T cell reservoir. Wu VH, Nordin JML, Nguyen S, Joy J, Mampe F, Del Rio Estrada PM, Torres-Ruiz F, González-Navarro M, Luna-Villalobos YA, Ávila-Ríos S, Reyes-Terán G, Tebas P, Montaner LJ, Bar KJ, Vella LA, Betts MR. Nat Immunol. 2023 Feb;24(2):359-370. doi: 10.1038/s41590-022-01371-3. Epub 2022 Dec 19. PMID: 36536105
Lung function and collagen 1a levels are associated with changes in 6 min walk test distance during treatment of TB among HIV-infected adults: a prospective cohort study. Baik Y, Maenetje P, Schramm D, Tiemessen C, Ncube I, Churchyard G, Wallis R, Vangu MD, Kornfeld H, Li Y, Auld SC, Bisson GP. BMC Pulm Med. 2023 Feb 3;23(1):53. doi: 10.1186/s12890-023-02325-7. PMID: 36737697
Allosteric autoregulation of DNA binding via a DNA-mimicking protein domain: a biophysical study of ZNF410-DNA interaction using small angle X-ray scattering. Kaur G, Ren R, Hammel M, Horton JR, Yang J, Cao Y, He C, Lan F, Lan X, Blobel GA, Blumenthal RM, Zhang X, Cheng X. Nucleic Acids Res. 2023 Feb 28;51(4):1674-1686. doi: 10.1093/nar/gkac1274.P MID: 36660822
Yersinia interactions with regulated cell death pathways. Chen KW, Brodsky IE. Curr Opin Microbiol. 2023 Feb;71:102256. doi: 10.1016/j.mib.2022.102256. Epub 2022 Dec 28. PMID: 36584489
Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Yang F, Zhang D, Jiang H, Ye J, Zhang L, Bagley SJ, Winkler J, Gong Y, Fan Y. Sci Transl Med. 2023 Feb 15;15(683):eabq3558. doi: 10.1126/scitranslmed.abq3558. Epub 2023 Feb 15. PMID: 36791206
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Brewer RC, Lanz TV, Hale CR, Sepich-Poore GD, Martino C, Swafford AD, Carroll TS, Kongpachith S, Blum LK, Elliott SE, Blachere NE, Parveen S, Fak J, Yao V, Troyanskaya O, Frank MO, Bloom MS, Jahanbani S, Gomez AM, Iyer R, Ramadoss NS, Sharpe O, Chandrasekaran S, Kelmenson LB, Wang Q, Wong H, Torres HL, Wiesen M, Graves DT, Deane KD, Holers VM, Knight R, Darnell RB, Robinson WH, Orange DE. Sci Transl Med. 2023 Feb 22;15(684):eabq8476. doi: 10.1126/scitranslmed.abq8476. Epub 2023 Feb 22. PMID: 36812347
Malaria-driven adaptation of MHC class I in wild bonobo populations. Wroblewski EE, Guethlein LA, Anderson AG, Liu W, Li Y, Heisel SE, Connell AJ, Ndjango JN, Bertolani P, Hart JA, Hart TB, Sanz CM, Morgan DB, Peeters M, Sharp PM, Hahn BH, Parham P. Nat Commun. 2023 Feb 23;14(1):1033. doi: 10.1038/s41467-023-36623-9. PMID: 36823144
Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis. Xiao Y, Batmanov K, Hu W, Zhu K, Tom AY, Guan D, Jiang C, Cheng L, McCright SJ, Yang EC, Lanza MR, Liu Y, Hill DA, Lazar MA. Sci Transl Med. 2023 Feb 8;15(682):eadc9653. doi: 10.1126/scitranslmed.adc9653. Epub 2023 Feb 8. PMID: 36753562

Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity. Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von Büdingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Or A. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2207291120. doi: 10.1073/pnas.2207291120. Epub 2023 Jan 12. PMID: 36634138
Improvement of Refractory Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease with Single-Agent Blockade of IL-1β and IL-18. Rood JE, Rezk A, Pogoriler J, Finn LS, Burnham JM, Josephson MB, Bar-Or A, Behrens EM, Canna SW. J Clin Immunol. 2023 Jan;43(1):101-108. doi: 10.1007/s10875-022-01353-y. Epub 2022 Aug 25. PMID: 36006569
Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction . Qiu J, Xu B, Ye D, Ren D, Wang S, Benci JL, Xu Y, Ishwaran H, Beltra JC, Wherry EJ, Shi J, Minn AJ. Nat Cancer. 2023 Jan;4(1):43-61. doi: 10.1038/s43018-022-00490-y. Epub 2023 Jan 16. PMID: 36646856
An extended SARS-CoV-2 mRNA vaccine prime-boost interval enhances B cell immunity with limited impact on T cells. Nicolas A, Sannier G, Dubé M, Nayrac M, Tauzin A, Painter MM, Goel RR, Laporte M, Gendron-Lepage G, Medjahed H, Williams JC, Brassard N, Niessl J, Gokool L, Morrisseau C, Arlotto P, Tremblay C, Martel-Laferrière V, Finzi A, Greenplate AR, Wherry EJ, Kaufmann DE. iScience. 2023 Jan 20;26(1):105904. doi: 10.1016/j.isci.2022.105904. Epub 2022 Dec 29. PMID: 36594081
Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma. Uslu U, Da T, Assenmacher CA, Scholler J, Young RM, Tchou J, June CH. Sci Adv. 2023 Jan 13;9(2):eade2526. doi: 10.1126/sciadv.ade2526. Epub 2023 Jan 11. PMID: 36630514
Nucleoside-Modified mRNA-Based Influenza Vaccines Circumvent Problems Associated with H3N2 Vaccine Strain Egg Adaptation. Gouma S, Furey C, Santos JJS, Parkhouse K, Weirick M, Muramatsu H, Pardi N, Fan SHY, Weissman D, Hensley SE. J Virol. 2023 Jan 31;97(1):e0172322. doi: 10.1128/jvi.01723-22. Epub 2022 Dec 19. PMID: 36533954
Forced enhancer-promoter rewiring to alter gene expression in animal models. Peslak SA, Demirci S, Chandra V, Ryu B, Bhardwaj SK, Jiang J, Rupon JW, Throm RE, Uchida N, Leonard A, Essawi K, Bonifacino AC, Krouse AE, Linde NS, Donahue RE, Ferrara F, Wielgosz M, Abdulmalik O, Hamagami N, Germino-Watnick P, Le A, Chu R, Hinds M, Weiss MJ, Tong W, Tisdale JF, Blobel GA. Mol Ther Nucleic Acids. 2023 Jan 31;31:452-465. doi: 10.1016/j.omtn.2023.01.016. eCollection 2023 Mar 14. PMID: 36852088
Yersinia Type III-Secreted Effectors Subvert Caspase-4-dependent Inflammasome Activation in Human Cells. Zhang J, Brodsky IE, Shin S. bioRxiv. 2023 Jan 25:2023.01.24.525473. doi: 10.1101/2023.01.24.525473. Preprint. PMID: 36747770
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies. Kennedy KM, de Goffau MC, Perez-Muñoz ME, Arrieta MC, Bäckhed F, Bork P, Braun T, Bushman FD, Dore J, de Vos WM, Earl AM, Eisen JA, Elovitz MA, Ganal-Vonarburg SC, Gänzle MG, Garrett WS, Hall LJ, Hornef MW, Huttenhower C, Konnikova L, Lebeer S, Macpherson AJ, Massey RC, McHardy AC, Koren O, Lawley TD, Ley RE, O'Mahony L, O'Toole PW, Pamer EG, Parkhill J, Raes J, Rattei T, Salonen A, Segal E, Segata N, Shanahan F, Sloboda DM, Smith GCS, Sokol H, Spector TD, Surette MG, Tannock GW, Walker AW, Yassour M, Walter J. Nature. 2023 Jan;613(7945):639-649. doi: 10.1038/s41586-022-05546-8. Epub 2023 Jan 25. PMID: 36697862
Role of Pfs47 in the dispersal of ancestral Plasmodium falciparum malaria through adaptation to different anopheline vectors.
Molina-Cruz A, Canepa GE, Dwivedi A, Liu W, Raytselis N, Antonio-Nkondjio C, Hahn BH, Silva JC, Barillas-Mury C. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2213626120. doi: 10.1073/pnas.2213626120. Epub 2023 Jan 23. PMID: 36689648
Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity. Laumaea A, Marchitto L, Ding S, Beaudoin-Bussières G, Prévost J, Gasser R, Chatterjee D, Gendron-Lepage G, Medjahed H, Chen HC, Smith AB 3rd, Ding H, Kappes JC, Hahn BH, Kirchhoff F, Richard J, Duerr R, Finzi A. Cell Rep. 2023 Jan 31;42(1):111983. doi: 10.1016/j.celrep.2022.111983. Epub 2023 Jan 10. PMID: 36640355
Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome. Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh AE, Nelson CA, Bryer JS, Ashchyan HA, Steele K, Forrestel A, Seykora JT, Micheletti RG, James WD, Rosenbach M, Leung TH. J Clin Invest. 2023 Jan 3;133(1):e162137. doi: 10.1172/JCI162137. PMID: 36355435

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