Perelman School of Medicine at the University of Pennsylvania

June Lab

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Carl June speaking at a celebration of FDA approved Kymriah 2017

Carl June, MD

Richard W. Vague Professor in Immunotherapy
Director, Center for Cellular Immunotherapies
Director, Parker Institute for Cancer Therapy
University of Pennsylvania
Perelman School of Medicine
3400 Civic Center Blvd
STRC 421 8-123
Philadelphia, PA 19104-5156
cjune@upenn.edu

 

 

Carl June is the Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine. He is currently Director of the Center for Cellular Immunotherapies at the Perelman School of Medicine, and Director of the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania. He is a graduate of the Naval Academy in Annapolis, and Baylor College of Medicine in Houston, 1979. He had graduate training in Immunology and malaria with Dr. Paul-Henri Lambert at the World Health Organization, Geneva, Switzerland from 1978-79, and post-doctoral training in transplantation biology with E. Donnell Thomas and John Hansen at the Fred Hutchinson Cancer Research Center in Seattle from 1983 - 1986. He is board certified in Internal Medicine and Medical Oncology. He maintains a research laboratory that studies various mechanisms of lymphocyte activation that relate to immune tolerance and adoptive immunotherapy for cancer and chronic infection. In 2011, his research team published findings detailing a new therapy in which patients with refractory and relapsed chronic lymphocytic leukemia were treated with genetically engineered versions of their own T cells. The treatment has  been approved by the US FDA in 2017 as tisagenlecleucel for leukemia and lymphoma. He has published more than 450 manuscripts and is the recipient of numerous prizes and honors, including election to the Institute of Medicine in 2012 and the American Academy of Arts and Sciences in 2014, the William B Coley award, the Richard V Smalley Memorial Award from the Society for Immunotherapy of Cancer, the AACR-CRI Lloyd J. Old Award in Cancer Immunology, the Philadelphia Award in 2012, the Taubman Prize for Excellence in Translational Medical Science in 2014 (shared w S. Grupp, B. Levine, D. Porter), the Paul Ehrlich and Ludwig Darmstaedter Prize (shared w J. Allison), the Novartis Prize in Immunology (shared w Z. Eshaar and S. Rosenberg), the Karl Landsteiner Memorial award, the Debrecen Award, the Passano Award (shared w M. Sadelain), the Albany Medical Prize (shared w J Allison and S. Rosenberg), and a lifetime achievement award from the Leukemia and Lymphoma Society and in 2017, he was elected a fellow of the American Association for Cancer Research Academy and received the David A. Karnofsky Memorial Award from the American Society of Clinical Oncology.

Current NIH Biosketch