Perelman School of Medicine at the University of Pennsylvania

Maxwell Lab

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WELCOME

Welcome to the Maxwell lab!

Welcome to the Maxwell lab!  We are a translational human genetics and genomics research laboratory studying mechanisms of tumor formation in inherited cancer syndromes. We have a focus on breast and prostate cancer, but are interested in the broad range of tumor types affected by DNA repair deficiency. We are using multi-omics analyses of human samples coupled with in vitro and in vivo modelling systems to understand how tumors form in patients with inherited cancers. We are also interested in environmental and other determinants of disease penetrance in patients at risk for breast and prostate cancer.

In order to perform our studies, we leverage the resources of the Basser Center for BRCA (https://www.basser.org/) and the Penn Medicine Biobank (https://www.itmat.upenn.edu/biobank/).

We take a multi-disciplinary approach, collaborating with our colleagues across basic science labs and the clinical arena.

Rotation/Postdoc projects:

  1. Mechanisms of tumor formation in CHEK2 mutation carriers
  2. Prostate Cancer Genetics
  3. Determinants of penetrance and advances in clinical management of low risk TP53 mutation carriers
  4. Utility of polygenic risk scores in cancer risk
  5. Extreme cholesterol lowering in breast cancer

Announcement

Recruitment 

URGENT - COVID-19 Projects

We are in urgent need of help with our COVID-19 studies within cancer patients, specifically COSERCA (COVID-19 SERoprevalence in CAncer patients). More details can be found here. 

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Postdoctoral researchers

We are always looking for qualified and enthusiastic applicants interested in joining our team. In particular, individuals seeking opportunities at the postdoctoral level are encouraged to apply.

Penn graduate students

We have rotation projects available. Dr. Maxwell is a member of the Graduate Group in Genomics and Computational Biology (GCB) and Cell & Molecular Biology Graduate Group (CAMB).  

Penn undergraduate students

There are also research opportunities open within our lab for Penn undergraduate students. 

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For patient inquiries

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