Current Grant Support

NIH R21 AG095658

3D MRI Method for CMRO2 Mapping of the Brain in Dementia

To assess renal MRO₂ as a marker of early-stage diabetic kidney disease through quantification of renal MRO₂, eGFR, and microalbuminuria in prediabetic and type-2 diabetic patients in comparison to healthy reference subjects. (PI: F.W. Wehrli)

NIH R01 DE034733

Simultaneous PET/MR Imaging of Brain Glucose and Oxygen Metabolism to Assess Energy Deficits Related to Alzheimer’s Disease and the Response to Intervention

To develop clinically practical, noninvasive imaging methods based on combined positron emission tomography and magnetic resonance imaging to assess brain energy to better understand how this critical component of brain health is impacted by aging.T (PI: F.W. Wehrli, Keith St. Lawrence)

NIH R01 HL172928

Time-Resolved MRI Method for EEG Assisted Concurrent Mapping of Cerebral Oxygen Metabolism and Airway Structure in Obstructive Sleep Apnea

To apply novel imaging methodology to study the adverse effects of OSA on the brain along with measurement of airway obstruction toward new insight into the disorder and to aid in designing improved forms of treatment. (PI: F.W. Wehrli)

NIH R01 DE034733  

Single-Scan Multi-Contrast Cranial MRI in Pediatric Patients

To develop a clinically practical, radiation-free method for pre- and post-operative evaluation of pediatric patients with craniofacial anomalies while simultaneously assessing neurological soft tissue and bony malformations and acquire measurements of surgically relevant cranial distances. (PI: F.W. Wehrli)

NIH T32 EB020087 

Training in Structural, Physiologic and Functional MRI 

To train predoctoral candidates in MRI physics and engineering, with particular focus on structural, physiologic and functional applications, for a period of two years. (PI: F.W. Wehrli, C.S. Rajapakse, J. Gee. W.R.T. Witschey)

NIH R01 AR076392 

MRI Assessment of Hip Fracture Risk and Therapy Response in HIV/HCV Coinfection 

To change and improve how bone disease is clinically managed and to reduce the burdens of hip fracture in patient infected with HIV and HCV. (PI: C.S. Rajapakse)