Peer Reviewed Journal Publications

  • Lee H, Xu J, Fernandez-Seara MA, Wehrli FW. Validation of a new 3Dquantitative BOLD based cerebral oxygen extraction mapping. J Cereb Blood Flow Metab. 2024 Jan 30:271678X231220332. 
  • Nabbout M, Langham MC, Cottrell C, Wehrli FW. Quantification of neurovascular compliance with retrospectively gated phase-contrast MRI. MAGMA. 2024 Jan 9.
  • Deshpande RS, Langham MC, Susztak K, Wehrli FW. MRI-based quantification of whole-organ renal metabolic rate of oxygen. NMR Biomed. 2024 Jan;37(1):e5036.
  • Kamona N, Jones BC, Lee H, Song HK, Rajapakse CS, Wagner CS, Bartlett SP, Wehrli FW. Cranial bone imaging using ultrashort echo-time bone-selective MRI as an alternative to gradient-echo based "black-bone" techniques. MAGMA. 2024 Feb;37(1):83-92. 
  • Schwab RJ, Lin TC, Wiemken A, Dedhia RC, Wehrli FW, Keenan BT. State-dependent biomechanical behavior of oropharyngeal structures in apneics and controls: a proof-of-concept study. Ann Am Thorac Soc. 2024 Mar 20. 
  • Xu J, Wiemken A, Langham MC, Rao H, Nabbout M, Caporale AS, Schwab RJ, Detre JA, Wehrli FW. Sleep-stage-dependent alterations in cerebral oxygen metabolism quantified by magnetic resonance. J Neurosci Res. 2024 Mar;102(3):e25313. 
  • Deshpande RS, Langham MC, Lee H, Kamona N, Wehrli FW. Quantification of whole-organ individual and bilateral renal metabolic rate of oxygen. Magn Reson Med. 2024 May;91(5):2057-2073. 

  • Jones BC, Lee H, Cheng CC, Al Mukaddam M, Song HK, Snyder PJ, Kamona N, Rajapakse CS, Wehrli FW. MRI Quantification of cortical bone porosity, mineralization, and morphologic structure in postmenopausal osteoporosis. Radiology. 2023 Apr;307(2):e221810.
  • Caporale AS, Barclay AM, Xu J, Rao H, Lee H, Langham MC, Detre JA, Wehrli FW. Superior sagittal sinus flow as a proxy for tracking global cerebral blood flow dynamics during wakefulness and sleep. J Cereb Blood Flow Metab. 2023 Aug;43(8):1340-1350.
  • Jones BC, Wehrli FW, Kamona N, Deshpande RS, Vu BD, Song HK, Lee H, Grewal RK, Chan TJ, Witschey WR, MacLean MT, Josselyn NJ, Iyer SK, Al Mukaddam M, Snyder PJ, Rajapakse CS. Automated, calibration-free quantification of cortical bone porosity and geometry in postmenopausal osteoporosis from ultrashort echo time MRI and deep learning. Bone. 2023 Jun;171:116743.
  • Rekawek P, Herbst EA, Suri A, Ford BP, Rajapakse CS, Panchal N. Machine Learning and Artificial Intelligence: A web-based implant failure and peri-implantitis prediction model for clinicians. Int J Oral Maxillofac Implants. 2023 May, Jun;38(3):576-582b.
  • Suri A, Tang S, Kargilis D, Taratuta E, Kneeland BJ, Choi G, Agarwal A, Anabaraonye N, Xu W, Parente JB, Terry A, Kalluri A, Song K, Rajapakse CS. Conquering the cobb angle: a deep learning algorithm for automated, hardware- invariant measurement of Ccobb angle on radiographs in patients with scoliosis. Radiol Artif Intell. 2023 Jun 21;5(4):e220158.
  • Chan TJ, Rajapakse CS. A super-resolution diffusion model for recovering bone microstructure from CT Images. Radiol Artif Intell. 2023 Sep 20;5(6):e220251.
  • Chesnais H, Bastin N, Miguez S, Kargilis D, Kalluri A, Terry A, Rajapakse CS. Predicting Fractures Using Vertebral 18F-NaF Uptake in Prostate Cancer Patients. J Bone Metab. 2023 Nov;30(4):329-337. 
  • Tadros SS, Epsley S, Mehta S, Jones BC, Rajapakse HI, Madi R, Alecxih A, Kargilis D, Rajapakse CS. The Application of Advanced Bone Imaging Technologies in Sports Medicine. Radiol Res Pract. 2023 Dec 4;2023:7412540. 
  • Vu BD, Jones BC, Lee H, Kamona N, Deshpande RS, Wehrli FW, Rajapakse CS. Six-minute, in vivo MRI quantification of proximal femur trabecular bone 3D microstructure. Bone. 2023 Dec;177:116900.
  • Lin JK, Hearn CM, Getzen E, Long Q, Lee DC, Keaveny TM, Jayadevappa R, Robinson KW, Wong YN, Maxwell KN, Narayan V, Haas NB, Takvorian SU, Bikle DD, Chiang JM, Khan AN, Rajapakse CS, Morgans AK, Parikh RB. Validation of biomechanical computed tomography for fracture risk classification in metastatic hormone-sensitive prostate cancer. Eur Urol Oncol. 2023 Nov 3:S2588-9311(23)00230-4.

  • Lee H, Wehrli FW. Whole-brain 3D mapping of oxygen metabolism using constrained quantitative BOLD. Neuroimage. 2022 Apr 15;250:118952. 
  • Moon BF, Iyer SK, Josselyn NJ, Hwuang E, Swago S, Keeney SJ, Castillero E, Ferrari G, Pilla JJ, Gorman JH, Gorman RC, Tschabrunn CM, Shou H, Matthai W, Wehrli FW, Ferrari VA, Han Y, Litt H, Witschey WR. Magnetic susceptibility and R2* of myocardial reperfusion injury at 3T and 7T. Magn Reson Med. 2022 Jan;87(1):323-336. 
  • Zimmerman CE, Khandelwal P, Xie L, Lee H, Song HK, Yushkevich PA, Vossough A, Bartlett SP, Wehrli FW. Automatic segmentation of bone selective MR Images for visualization and craniometry of the cranial vault. Acad Radiol. 2022 Mar;29 Suppl 3(Suppl 3):S98-S106.
  • Wu PH, Rodríguez-Soto AE, Wiemken A, Englund EK, Rodgers ZB, Langham MC, Schwab RJ, Detre JA, Guo W, Wehrli FW. MRI evaluation of cerebral metabolic rate of oxygen (CMRO2) in obstructive sleep apnea. J Cereb Blood Flow Metab. 2022 Jan 7:271678X211071018.
  • Caporale A, Bonomo GB, Tani Raffaelli G, Tata AM, Avallone B, Wehrli FW, Capuani S. Transient anomalous diffusion MRI in excised mouse spinal cord: comparison among different diffusion metrics and validation with histology. Front Neurosci. 2022 Feb 15;15:797642.
  • Chiarelli AM, Germuska M, Chandler H, Stickland R, Patitucci E, Biondetti E, Mascali D, Saxena N, Khot S, Steventon J, Foster C, Rodríguez-Soto AE, Englund E, Murphy K, Tomassini V, Wehrli FW, Wise RG. A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMRO2) with single gas calibrated fMRI. J Cereb Blood Flow Metab. 2022 Jul;42(7):1192-1209. 
  • Guha I, Zhang X, Rajapakse CS, Chang G, Saha PK. Finite element analysis of trabecular bone microstructure using CT imaging and continuum mechanical modeling. Med Phys. 2022 Jun;49(6):3886-3899.
  • Bellomo TR, Tsao NL, Johnston-Cox H, Borkowski K, Shakt G, Judy R, Moore J, Ractcliffe SJ, Fiehn O, Floyd TF, Wehrli FW, Mohler E, Newman JW, Damrauer SM. Metabolite patterns associated with individual response to supervised exercise therapy in patients with intermittent claudication.  J Vasc Sci. 2022 Oct 25;3:379-388. 
  • Jain V, de Godoy LL, Mohan S, Chawla S, Learned K, Jain G, Wehrli FW, Alonso-Basanta M. Cerebral hemodynamic and metabolic dysregulation in the postradiation brain. J Neuroimaging. 2022 Nov;32(6):1027-1043. 
  • Englund EK, Langham MC, Wehrli FW, Fanning MJ, Khan Z, Schmitz KH, Ratcliffe SJ, Floyd TF, Mohler ER 3rd. Impact of supervised exercise on skeletal muscle blood flow and vascular function measured with MRI in patients with peripheral artery disease. Am J Physiol Heart Circ Physiol. 2022 Sep 1;323(3):H388-H396.
  • Deshpande RS, Langham MC, Cheng CC, Wehrli FW. Metabolism of oxygen via T2 and interleaved velocity encoding: A rapid method to quantify whole-brain cerebral metabolic rate of oxygen. Magn Reson Med. 2022 Sep;88(3):1229-1243. 
  • Nguyen JC, Baghdadi S, Pogoriler J, Guariento A, Rajapakse CS, Arkader A. Pediatric osteosarcoma: correlation of imaging findings with histopathologic features, treatment, and outcome. Radiographics. 2022 Jul-Aug;42(4):1196-1213.
  • Dai M, Xu W, Chesnais H, Anabaraonye N, Parente J, Chatterjee S, Rajapakse CS. Atherogenic indices as a predictor of aortic calcification in prostate cancer patients assessed using 18F-sodium fluoride PET/CT. Int J Mol Sci. 2022 Oct 27;23(21):13056. 

  • Jones BC, Jia S, Lee H, Feng A, Shetye SS, Batzdorf A, Shapira N, Noël PB, Pleshko N, Rajapakse CS. MRI-derived porosity index is associated with whole- bone stiffness and mineral density in human cadaveric femora. Bone. 2021 Feb;143:115774.
  • Lee H, Wehrli FW. Alternating unbalanced SSFP for 3D R2' mapping of the human brain. Magn Reson Med. 2021 May;85(5):2391-2402. 
  • Chatterjee S, Caporale A, Tao JQ, Guo W, Johncola A, Strasser AA, Leone FT, Langham MC, Wehrli FW. Acute e-cig inhalation impacts vascular health: a study in smoking naïve subjects. Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H144-H158.
  • Langham MC, Caporale AS, Wehrli FW, Parry S, Schwartz N. Evaluation of vascular reactivity of maternal vascular adaptations of pregnancy With quantitative MRI: pilot study. J Magn Reson Imaging. 2021 Feb;53(2):447-455.
  • Rajapakse CS, Johncola AJ, Batzdorf AS, Jones BC, Al Mukaddam M, Sexton K, Shults J, Leonard MB, Snyder PJ, Wehrli FW. Effect of low-intensity vibration on bone strength, microstructure, and adiposity in pre-osteoporotic postmenopausal women: a randomized placebo-controlled trial. J Bone Miner Res. 2021 Apr;36(4):673-684. 
  • Caporale A, Lee H, Lei H, Rao H, Langham MC, Detre JA, Wu PH, Wehrli FW. Cerebral metabolic rate of oxygen during transition from wakefulness to sleep measured with high temporal resolution OxFlow MRI with concurrent EEG. J Cereb Blood Flow Metab. 2021 Apr;41(4):780-792.
  • Narciso L, Ssali T, Liu L, Biernaski H, Butler J, Morrison L, Hadway J, Corsaut J, Hicks JW, Langham MC, Wehrli FW, Iida H, St Lawrence K. A noninvasive method for quantifying cerebral metabolic rate of oxygen by hybrid PET/MRI: validation in a porcine model. J Nucl Med. 2021 Mar 19:jnumed.120.260521.
  • Chaudhari AJ, Raynor WY, Gholamrezanezhad A, Werner TJ, Rajapakse CS, Alavi A. Total-body PET imaging of musculoskeletal disorders. PET Clin. 2021 Jan;16(1):99-117. 
  • Epsley S, Tadros S, Farid A, Kargilis D, Mehta S, Rajapakse CS. The effect of inflammation on bone. Front Physiol. 2021 Jan 5;11:511799. 
  • Ayubcha C, Raynor WY, Borja AJ, Seraj SM, Rojulpote C, Werner TJ, Revheim ME, Rajapakse CS, Alavi A. Magnetic resonance imaging-based partial volume-corrected 18F-sodium fluoride positron emission tomography in the femoral neck. Nucl Med Commun. 2021 Apr 1;42(4):416-420. 
  • Whitney DG, Kalia V, Rajapakse CS, Fedak Romanowski EM, Caird MS, Hurvitz EA, Jepsen KJ. The effect of age when initiating anti-seizure medication therapy on fragility fracture risk for children with epilepsy. Bone. 2021 Aug;149:115996.
  • Suri A, Jones BC, Ng G, Anabaraonye N, Beyrer P, Domi A, Choi G, Tang S, Terry A, Leichner T, Fathali I, Bastin N, Chesnais H, Rajapakse CS. A deep learning system for automated, multi-modality 2D segmentation of vertebral bodies and intervertebral discs. Bone. 2021 Aug;149:115972. 
  • Brodsky L, Chesnais H, Piri R, Høilund-Carlsen PF, Alavi A, Rajapakse CS. Association of baseline subject characteristics with changes in coronary calcification assessed by <sup>18</sup>F-sodium fluoride PET/CT. Hell J Nucl Med. 2021 Jan-Apr;24(1):45-52. 
  • Suri A, Jones BC, Ng G, Anabaraonye N, Beyrer P, Domi A, Choi G, Tang S, Terry A, Leichner T, Fathali I, Bastin N, Chesnais H, Taratuta E, Kneeland BJ, Rajapakse CS. Vertebral deformity measurements at MRI, CT, and radiography using deep learning. Radiol Artif Intell. 2021 Nov 10;4(1):e210015. 

  • Zhang R, Lee H, Zhao X, Song HK, Vossough A, Wehrli FW, Bartlett SP. Bone-selective MRI as a nonradiative alternative to CT for craniofacial imaging. Acad Radiol. 2020 Nov;27(11): 1515-1522. 
  • Mayer M, Borja AJ, Hancin EC, Auslander T, Revheim ME, Moghbel MC, Werner TJ, Alavi A, Rajapakse CS. Imaging atherosclerosis by PET, with emphasis on the role of FDG and NaF as potential biomarkers for this disorder. Front Physiol. 2020 Oct 22;11:511391.
  • Lee H, Wehrli FW. Venous cerebral blood volume mapping in the whole brain using venous-spin-labeled 3D turbo spin echo. Magn Reson Med. 2020 Oct;84(4):1991-2003. 
  • Zhao X, Lee H, Song HK, Cheng CC, Wehrli FW. Impact of gradient imperfections on bone water quantification with UTE MRI. Magn Reson Med. 2020 Oct;84(4):2034-2047. 
  • Lee H, Zhao X, Song HK, Wehrli FW. Self-navigated three-dimensional ultrashort echo time technique for motion-corrected skull MRI. IEEE Trans Med Imaging. 2020 Sep;39(9):2869-2880.
  • Eliav U, Wehrli FW, Navon G. New insight into the organization of myelin water using deuterium NMR. Magn Reson Med. 2020 Aug;84(2):535-541. 
  • Englund EK, Fernández-Seara MA, Rodríguez-Soto AE, Lee H, Rodgers ZB, Vidorreta M, Detre JA, Wehrli FW. Calibrated fMRI for dynamic mapping of CMRO2 responses using MR-based measurements of whole-brain venous oxygen saturation. J Cereb Blood Flow Metab. 2020 Jul;40(7):1501-1516. 
  • Sorci O, Batzdorf AS, Mayer M, Rhodes S, Peng M, Jankelovits AR, Hornyak JN, Gerke O, Høilund-Carlsen PF, Alavi A, Rajapakse CS. 18F-sodium fluoride PET/CT provides prognostic clarity compared to calcium and Framingham risk scoring when addressing whole-heart arterial calcification. Eur J Nucl Med Mol Imaging. 2020 Jul;47(7):1678-1687.
  • Ruderman I, Rajapakse CS, Opperman A, Robertson PL, Masterson R, Tiong MK, Toussaint ND. Bone microarchitecture in patients undergoing parathyroidectomy for management of secondary hyperparathyroidism. Bone Rep. 2020 Jul 15;13:100297.
  • Rhodes S, Batzdorf A, Sorci O, Peng M, Jankelovits A, Hornyak J, An J, Noël PB, Høilund-Carlsen PF, Alavi A, Rajapakse CS. Assessment of femoral neck bone metabolism using 18F-sodium fluoride PET/CT imaging. Bone. 2020 Jul;136:115351.
  • Demirtas A, Rajapakse CS, Ural A. Assessment of the multifactorial causes of atypical femoral fractures using a novel multiscale finite element approach.  Bone. 2020 Jun;135:115318
  • Wu PH, Rodríguez-Soto AE, Rodgers ZB, Englund EK, Wiemken A, Langham MC, Detre JA, Schwab RJ, Guo W, Wehrli FW. MRI evaluation of cerebrovascular reactivity in obstructive sleep apnea. J Cereb Blood Flow Metab. 2020 Jun;40(6):1328-1337.
  • Moon BF, Iyer SK, Hwuang E, Solomon MP, Hall AT, Kumar R, Josselyn NJ, Higbee-Dempsey EM, Tsourkas A, Imai A, Okamoto K, Saito Y, Pilla JJ, Gorman JH 3rd, Gorman RC, Tschabrunn C, Keeney SJ, Castillero E, Ferrari G, Jockusch S, Wehrli FW, Shou H, Ferrari VA, Han Y, Gulhane A, Litt H, Matthai W, Witschey WR. Iron imaging in myocardial infarction reperfusion injury. Nat Commun. 2020 Jun 29;11(1):3273. 
  • Demirtas A, Rajapakse CS, Ural A. Assessment of the multifactorial causes of atypical femoral fractures using a novel multiscale finite element approach. Bone. 2020 Jun;135:115318.
  • Wehrli FW, Caporale A, Langham MC, Chatterjee S. New insights from MRI and cell biology into the acute vascular-metabolic implications of electronic cigarette vaping. Front Physiol. 2020 May 21;11:492. 
  • Ailavajhala R , Querido W , Rajapakse CS , Pleshko N . Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water. Analyst. 2020 May 21;145(10):3713-3724.
  • Rajapakse CS, Farid AR, Kargilis DC, Jones BC, Lee JS, Johncola AJ, Batzdorf AS, Shetye SS, Hast MW, Chang G. MRI-based assessment of proximal femur strength compared to mechanical testing. Bone. 2020 Apr;133:115227.
  • Kligerman S, Raptis C, Larsen B, Henry TS, Caporale A, Tazelaar H, Schiebler ML, Wehrli FW, Klein JS, Kanne J. Radiologic, pathologic, clinical, and physiologic findings of electronic cigarette or vaping product use-associated lung injury (EVALI): evolving knowledge and remaining questions. Radiology. 2020 Mar;294(3):491-505. 
  • Englund EK, Langham MC. Quantitative and dynamic MRI measures of peripheral vascular function. Front Physiol. 2020 Feb 28;11:120.

  • Leonard MB, Wehrli FW, Ziolkowski SL, Billig E, Long J, Nickolas TL, Magland JF, Nihtianova S, Zemel BS, Herskovitz R, Rajapakse CS. A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease. Bone. 2019 Oct;127:271-279.
  • Caporale A, Langham MC, Guo W, Johncola A, Chatterjee S, Wehrli FW. Acute effects of electronic cigarette aerosol inhalation on vascular function detected at quantitative MRI. Radiology. 2019 Oct;293(1):97-106.
  • Chatterjee S, Tao JQ, Johncola A, Guo W, Caporale A, Langham MC, Wehrli FW. Acute exposure to e-cigarettes causes inflammation and pulmonary endothelial oxidative stress in nonsmoking, healthy young subjects. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1;317(2):L155-L166.
  • Englund EK, Fernández-Seara MA, Rodríguez-Soto AE, Lee H, Rodgers ZB, Vidorreta M, Detre JA, Wehrli FW. Calibrated fMRI for dynamic mapping of CMRO(2) responses using MR-based measurements of whole-brain venous oxygen saturation. J Cereb Blood Flow Metab. 2019 Aug 8:271678X19867276.
  • Ailavajhala R, Oswald J, Rajapakse CS, Pleshko N. Environmentally-controlled near infrared spectroscopic imaging of bone water. Sci Rep.2019 Jul 15;9(1):10199.
  • Hong AL, Ispiryan M, Padalkar MV, Jones BC, Batzdorf AS, Shetye SS, Pleshko N, Rajapakse CS. MRI-derived bone porosity index correlates to bone composition and mechanical stiffness. Bone Rep. 2019 Jun 26;11:100213.
  • Rajapakse CS, Gupta N, Evans M, Alizai H, Shukurova M, Hong AL, Cruickshank NJ, Tejwani N, Egol K, Honig S, Chang G. Influence of bone lesion location on femoral bone strength assessed by MRI-based finite-element modeling. Bone. 2019 May;122:209-217.
  • Lee H, Zhao X, Song HK, Zhang R, Bartlett SP, Wehrli FW. Rapid dual-RF, dual-echo, 3D ultrashort echo time craniofacial imaging: A feasibility study. Magn Reson Med. 2019 May;81(5):3007-3016.
  • Ferizi U, Besser H, Hysi P, Jacobs J, Rajapakse CS, Chen C, Saha PK, Honig S, Chang G. Artificial intelligence applied to osteoporosis: a performance comparison of machine learning algorithms in predicting fragility fractures from MRI data. J Magn Reson Imaging. 2019 Apr;49(4):1029-1038.
  • Austin AG, Raynor WY, Reilly CC, Zadeh MZ, Werner TJ, Zhuang H, Alavi A, Rajapakse CS. Evolving role of MR imaging and PET in assessing osteoporosis. PET Clin. 2019 Jan;14(1):31-41.

  • Zhao X, Song HK, Wehrli FW. In vivo bone 31P relaxation times and their implications on mineral quantification. Magn Reson Med. 2018 Dec;80(6):2514-2524.
  • Rajapakse CS, Chang G. Micro-finite element analysis of the proximal femur on  the basis of high-resolution magnetic resonance images. Curr Osteoporos Rep. 2018 Dec;16(6):657-664.
  • Reilly CC, Raynor WY, Hong AL, Kargilis DC, Lee JS, Alecxih AG, Gupta N, Lim MK, Al-Zaghal A, Werner TJ, Rhodes SS, Alavi A, Rajapakse CS. Diagnosis and monitoring of osteoporosis with (18)F-sodium fluoride PET: an unavoidable for the foreseeable future. Semin Nucl Med. 2018 Nov;48(6):535-540.
  • Ayubcha C, Zirakchian Zadeh M, Stochkendahl MJ, Al-Zaghal A, Hartvigsen J, Rajapakse CS, Raynor W, Werner T, Thomassen A, Zhuang H, Høilund-Carlsen PF, Alavi A. Quantitative evaluation of normal spinal osseous metabolism with 18F-NaF PET/CT. Nucl Med Commun. 2018 Oct;39(10):945-950.
  • Sharma AK, Toussaint ND, Elder GJ, Masterson R, Holt SG, Robertson PL, Ebeling PR, Baldock P, Miller RC, Rajapakse CS. Magnetic resonance imaging based  assessment of bone microstructure as a non-invasive alternative to histomorphometry in patients with chronic kidney disease. Bone. 2018 Sep;114:14-21.
  • Rodríguez-Soto AE, Langham MC, Abdulmalik O, Englund EK, Schwartz N, Wehrli FW. MRI quantification of human fetal O2 delivery rate in the second and third trimesters of pregnancy. Magn Reson Med. 2018 Sep;80(3)L1148-1157. 
  • Ferizi U, Besser H, Hysi P, Jacobs J, Rajapakse CS, Chen C, Saha PK, Honig S,  Chang G. Artificial intelligence applied to osteoporosis: a performance comparison of machine learning algorithms in predicting fragility fractures from MRI data. J Magn Reson Imaging. 2018 Sep 25.
  • Sharma AK, Toussaint ND, Elder GJ, Rajapakse CS, Holt SG, Baldock P, Robertson PL, Ebeling PR, Sorci OR, Masterson R. Changes in bone microarchitecture following kidney transplantation-Beyond bone mineral density. Clin Transplant. 2018 Sep;32(9):e13347.
  • Sharma AK, Toussaint ND, Masterson R, Holt SG, Rajapakse CS, Ebeling PR, Mohanty ST, Baldock P, Elder GJ. Deterioration of Cortical Bone microarchitecture: critical component of renal osteodystrophy evaluation. Am J Nephrol. 2018 Jul;47(6):376-384.
  • Lee H, Englund EK, Wehrli FW. Interleaved quantitative BOLD: Combining extravascular R(2)' - and intravascular R(2)-measurements for estimation of deoxygenated blood volume and hemoglobin oxygen saturation. Neuroimage. 2018 Jul 1;174:420-431.
  • West SL, Rajapakse CS, Rayner T, Miller R, Slinger MA, Wells GD. The reproducibility of measuring trabecular bone parameters using a commercially available high-resolution magnetic resonance imaging approach: A pilot study. Bone Rep. 2018 Apr 26;8:180-186.
  • Langham MC, Rodríguez-Soto AE, Schwartz N, Wehrli FW. In vivo whole-blood T(2) versus HbO(2) calibration by modulating blood oxygenation level in the femoral vein through intermittent cuff occlusion. Magn Reson Med. 2018 Apr;79(4):2290-2296. 
  • Derakhshan JJ, McDonald ES, Siegelman ES, Schnall MD, Wehrli FW. Characterizing and eliminating errors in enhancement and subtraction artifacts in dynamic contrast-enhanced breast MRI: Chemical shift artifact of the third kind. Magn Reson Med. 2018 Apr;79(4):2277-2289. 
  • Rodríguez-Soto AE, Abdulmalik O, Langham MC, Schwartz N, Lee H, Wehrli FW. T(2) -prepared balanced steady-state free precession (bSSFP) for quantifying whole-blood oxygen saturation at 1.5T. Magn Reson Med. 2018 Apr;79(4):1893-1900. 
  • Al Mukaddam M, Rajapakse CS, Pignolo RJ, Kaplan FS, Smith SE. Imaging assessment of fibrodysplasia ossificans progressiva: Qualitative, quantitative and questionable. Bone. 2018 Apr;109:147-152.
  • Ayubcha C, Zadeh MZ, Rajapakse CS, Hartvigsen J, Stochkendahl MJ, Raynor W, Acosta-Montenegro O, Werner T, Zhuang H, Høilund-Carlsen PF, Alavi A. Effects of age and weight on the metabolic activities of the cervical, thoracic and lumbar spines as measured by fluorine-18 fluorodeoxyglucose-positron emission tomography in healthy males. Hell J Nucl Med. 2018 Mar 20. pii: s002449910700. 
  • Rajapakse CS, Kobe EA, Batzdorf AS, Hast MW, Wehrli FW. Accuracy of MRI-based finite element assessment of distal tibia compared to mechanical testing. Bone. 2018 Mar;108:71-78. 
  • Chang G, Rajapakse CS, Chen C, Welbeck A, Egol K, Regatte RR, Saha PK, Honig S. 3-T MR imaging of proximal femur microarchitecture in subjects with and without fragility fracture and nonosteoporotic proximal femur bone mineral density. Radiology. 2018 Feb 19:170138.
  • Englund EK, Rodgers ZB, Langham MC, Mohler ER, Floyd TF, Wehrli FW. Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption. Magn Reson Med. 2018 Feb;79(2):846-855. 
  • Cao W, Chang YV, Englund EK, Song HK, Barhoum S, Rodgers ZB, Langham MC, Wehrli FW. High-speed whole-brain oximetry by golden-angle radial MRI. Magn Reson Med. 2018 Jan;79(1):217-223. 

  • Seifert AC, Li C, Wilhelm MJ, Wehrli SL, Wehrli FW. Towards quantification of myelin by solid-state MRI of the lipid matrix protons.Neuroimage. 2017 Dec;163:358-367. 
  • Rajapakse CS, Leonard MB, Kobe EA, Slinger MA, Borges KA, Billig E, Rubin CT, Wehrli FW. The efficacy of low-intensity vibration to improve bone health in patients with end-stage renal disease is highly dependent on compliance and muscle response. Acad Radiol. 2017 Nov;24(11):1332-1342. 
  • Rajapakse CS, Padalkar MV, Yang HJ, Ispiryan M, Pleshko N. Non-destructive NIR spectral imaging assessment of bone water: Comparison to MRI measurements. Bone. 2017 Oct;103:116-124. 
  • Chang G, Boone S, Martel D, Rajapakse CS, Hallyburton RS, Valko M, Honig S, Regatte RR. MRI assessment of bone structure and microarchitecture. J Magn Reson Imaging. 2017 Aug;46(2):323-337. 
  • Rajapakse CS, Hotca A, Newman BT, Ramme A, Vira S, Kobe EA, Miller R, Honig S, Chang G. Patient-specific Hip Fracture Strength Assessment with Microstructural MR Imaging-based Finite Element Modeling. Radiology. 2017 Jun;283(3):854-861.
  • Wehrli FW, Fan AP, Rodgers ZB, Englund EK, Langham MC. Susceptibility-based time-resolved whole-organ and regional tissue oximetry.NMR Biomed. 2017 Apr;30(4). 
  • Lee H, Langham MC, Rodriguez-Soto AE, Wehrli FW. Multiplexed MRI methods for  rapid estimation of global cerebral metabolic rate of oxygen consumption. Neuroimage. 2017 Apr 1;149:393-403. 
  • Li C, Magland JF, Zhao X, Seifert AC, Wehrli FW. Selective in vivo bone imaging with long-T(2) suppressed PETRA MRI. Magn Reson Med. 2017 Mar;77(3):989-997. 
  • Zhao X, Song HK, Seifert AC, Li C, Wehrli FW. Feasibility of assessing bone matrix and mineral properties in vivo by combined solid-state 1H and 31P MRI. PLoS One. 2017 Mar 15;12(3):e0173995. Erratum in: PLoS One. 2018 Jan 29;13(1):e0192186. 
  • Rajapakse CS, Lindborg C, Wang H, Newman BT, Kobe EA, Chang G, Shore EM, Kaplan FS, Pignolo RJ. Analog method for radiographic assessment of heterotopic bone in Fibrodysplasia Ossificans Progressiva. Acad Radiol. 2017 Mar;24(3):321-32

  • Fernández-Seara MA, Rodgers ZB, Englund EK, Wehrli FW. Calibrated bold fMRI with an optimized ASL-BOLD dual-acquisition sequence.Neuroimage. 2016 Nov 15;142:474-482. 
  • Englund EK, Rodgers ZB, Langham MC, Mohler ER 3rd, Floyd TF, Wehrli FW. Measurement of skeletal muscle perfusion dynamics with pseudo-continuous arterial spin labeling (pCASL): Assessment of relative labeling efficiency at rest and during hyperemia, and comparison to pulsed arterial spin labeling (PASL). J Magn Reson Imaging. 2016 Oct;44(4):929-39. 
  • Chen C, Jin D, Liu Y, Wehrli FW, Chang G, Snyder PJ, Regatte RR, Saha PK. Trabecular bone characterization on the continuum of plates and rods using in vivo MR imaging and volumetric topological analysis. Phys Med Biol. 2016 Sep 21;61(18):N478-N496. 
  • Seifert AC, Wehrli FW. Erratum to: Solid-state quantitative (1)H and (31)P MRI of cortical bone in humans. Curr Osteoporos Rep. 2016 Aug;14(4):159-161. 
  • Raynor W, Houshmand S, Gholami S, Emamzadehfard S, Rajapakse CS, Blomberg BA, Werner TJ, Høilund-Carlsen PF, Baker JF, Alavi A. Evolving role of molecular imaging with (18)F-sodium fluoride PET as a biomarker for calcium metabolism. Curr Osteoporos Rep. 2016 Aug;14(4):115-25. Review.
  • Li C, Seifert AC, Rad HS, Bhagat YA, Rajapakse CS, Sun W, Benny Lam SC, Wehrli FW. Cortical bone water concentration: dependence of MR imaging measures on age and pore volume fraction. Radiology. 2016 Aug;280(2):653. 
  • Rodgers ZB, Detre JA, Wehrli FW. MRI-based methods for quantification of the cerebral metabolic rate of oxygen. J Cereb Blood Flow Metab.2016 Jul;36(7):1165-85.
  • Seifert AC, Wehrli FW. Solid-state quantitative (1)H and (31)P MRI of cortical bone in humans. Curr Osteoporos Rep. 2016 Jun;14(3):77-86. Review. Erratum in: Curr Osteoporos Rep. 2016 Aug;14(4):159-61. 
  • Langham MC, Desjardins B, Englund EK, Mohler ER 3rd, Floyd TF, Wehrli FW. Rapid high-resolution, self-registered, dual lumen-contrast MRI method for vessel-wall assessment in peripheral artery disease: a preliminary investigation. Acad Radiol. 2016 Apr;23(4):457-67. 
  • Wehrli FW, Fan AP, Rodgers ZB, Englund EK, Langham MC. Susceptibility-based time-resolved whole-organ and regional tissue oximetry. NMR Biomed. 2017 Apr;30(4). 
  • Li C, Magland JF, Zhao X, Seifert AC, Wehrli FW. Selective in vivo bone imaging with long-T(2) suppressed PETRA MRI. Magn Reson Med. 2017 Mar;77(3):989-997. 
  • Rodgers ZB, Leinwand SE, Keenan BT, Kini LG, Schwab RJ, Wehrli FW. Cerebral metabolic rate of oxygen in obstructive sleep apnea at rest and in response to breath-hold challenge. J Cereb Blood Flow Metab. 2016 Apr;36(4):755-67. 
  • Magland JF, Li C, Langham MC, Wehrli FW. Pulse sequence programming in a dynamic visual environment: SequenceTree. Magn Reson Med.2016 Jan;75(1):257-65.

  • Seifert AC, Li C, Wehrli SL, Wehrli FW. A Surrogate measure of cortical bone matrix density by long T2-suppressed MRI. J Bone Miner Res.2015 Dec;30(12):2229-38. 
  • Chang G, Rajapakse CS, Regatte RR, Babb J, Saxena A, Belmont HM, Honig S. 3 Tesla MRI detects deterioration in proximal femur microarchitecture and strength in long-term glucocorticoid users compared with controls. J Magn Reson Imaging. 2015 Dec;42(6):1489-96. 
  • Hotca A, Rajapakse CS, Cheng C, Honig S, Egol K, Regatte RR, Saha PK, Chang G. In vivo measurement reproducibility of femoral neck microarchitectural parameters derived from 3T MR images. J Magn Reson Imaging. 2015 Nov;42(5):1339-45. 
  • Barhoum S, Langham MC, Magland JF, Rodgers ZB, Li C, Rajapakse CS, Wehrli FW.  Method for rapid MRI quantification of global cerebral metabolic rate of oxygen.  J Cereb Blood Flow Metab. 2015 Oct;35(10):1616-22. 
  • Mostoufi-Moab S, Magland J, Isaacoff EJ, Sun W, Rajapakse CS, Zemel B, Wehrli F, Shekdar K, Baker J, Long J, Leonard MB. Adverse fat depots and marrow adiposity are associated with skeletal deficits and insulin resistance in long-term survivors of pediatric hematopoietic stem cell transplantation. J Bone Miner Res. 2015 Sep;30(9):1657-66.
  • Chang G, Hotca-Cho A, Rusinek H, Honig S, Mikheev A, Egol K, Regatte RR, Rajapakse CS. Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength. MAGMA.2015 Aug;28(4):407-12.
  • Rajapakse CS, Bashoor-Zadeh M, Li C, Sun W, Wright AC, Wehrli FW. Volumetric cortical bone porosity assessment with MR imaging: validation and clinical feasibility. Radiology. 2015 Aug;276(2):526-35.
  • Seifert AC, Wehrli SL, Wehrli FW. Bi-component T2 * analysis of bound and pore bone water fractions fails at high field strengths. NMR Biomed. 2015 Jul;28(7):861-72. 
  • Barhoum S, Rodgers ZB, Langham M, Magland JF, Li C, Wehrli FW. Comparison of MRI methods for measuring whole-brain venous oxygen saturation. Magn Reson Med. 2015 Jun;73(6):2122-8.
  • Chang G, Honig S, Liu Y, Chen C, Chu KK, Rajapakse CS, Egol K, Xia D, Saha PK, Regatte RR. 7 Tesla MRI of bone microarchitecture discriminates between women without and with fragility fractures who do not differ by bone mineral density. J Bone Miner Metab. 2015 May;33(3):285-93. 
  • Zhang N, Magland JF, Song HK, Wehrli FW. Registration-based autofocusing technique for automatic correction of motion artifacts in time-series studies of high-resolution bone MRI. J Magn Reson Imaging. 2015 Apr;41(4):954-63. 
  • Englund EK, Langham MC, Ratcliffe SJ, Fanning MJ, Wehrli FW, Mohler ER 3rd, Floyd TF. Multiparametric assessment of vascular function in peripheral artery disease: dynamic measurement of skeletal muscle perfusion, blood-oxygen-level dependent signal, and venous oxygen saturation. Circ Cardiovasc Imaging. 2015 Apr;8(4). 
  • Rodgers ZB, Englund EK, Langham MC, Magland JF, Wehrli FW. Rapid T2- and susceptometry-based CMRO2 quantification with interleaved TRUST (iTRUST). Neuroimage. 2015 Feb 1;106:441-50. 
  • Langham MC, Zhou Y, Chirico EN, Magland JF, Sehgal CM, Englund EK, Mohler ER 3rd, Guo W, Barhoum S, Wehrli FW. Effects of age and smoking on endothelial function assessed by quantitative cardiovascular magnetic resonance in the peripheral and central vasculature. J Cardiovasc Magn Reson. 2015 Feb 19;17:19.
  • Chang G, Brown R, Regatte RR, Rajapakse CS. Response. Radiology. 2015 Feb;274(2):622-3. 
  • Magland JF, Li C, Langham MC, Wehrli FW. Pulse sequence programming in a dynamic visual environment: SequenceTree. Magn Reson Med.2016 Jan;75(1):257-65.

  • Wurnig MC, Calcagni M, Kenkel D, Vich M, Weiger M, Andreisek G, Wehrli FW, Boss A. Characterization of trabecular bone density with ultra-short echo-time MRI at 1.5, 3.0 and 7.0 T--comparison with micro-computed tomography. NMR Biomed. 2014 Oct;27(10):1159-66. 
  • Gong B, Mandair GS, Wehrli FW, Morris MD. Novel assessment tools for osteoporosis diagnosis and treatment. Curr Osteoporos Rep. 2014 Sep;12(3):357-65.
  • Review. 
  • Li C, Seifert AC, Rad HS, Bhagat YA, Rajapakse CS, Sun W, Lam SC, Wehrli FW. Cortical bone water concentration: dependence of MR imaging measures on age and pore volume fraction. Radiology. 2014 Sep;272(3):796-806. 
  • Chang G, Honig S, Brown R, Deniz CM, Egol KA, Babb JS, Regatte RR, Rajapakse CS. Finite element analysis applied to 3-T MR imaging of proximal femur microarchitecture: lower bone strength in patients with fragility fractures compared with control subjects. Radiology. 2014 Aug;272(2):464-74. 
  • Wink JD, Gerety PA, Sherif RD, Lim Y, Clarke NA, Rajapakse CS, Nah HD, Taylor  JA. Sustained delivery of rhBMP-2 by means of poly (lactic-co-glycolic acid) microspheres: cranial bone regeneration without heterotopic ossification or craniosynostosis. Plast Reconstr Surg. 2014 Jul;134(1):51-9. 
  • Seifert AC, Li C, Rajapakse CS, Bashoor-Zadeh M, Bhagat YA, Wright AC, Zemel BS, Zavaliangos A, Wehrli FW. Bone mineral (31)P and matrix-bound water densities measured by solid-state (31)P and (1)H MRI. NMR Biomed. 2014 Jul;27(7):739-48.
  • Chang G, Honig S, Liu Y, Chen C, Chu KK, Rajapakse CS, Egol K, Xia D, Saha PK, Regatte RR. 7 Tesla MRI of bone microarchitecture discriminates between women without and with fragility fractures who do not differ by bone mineral density. J Bone Miner Metab. 2015 May;33(3):285-93. 
  • Li C, Magland JF, Seifert AC, Wehrli FW. Correction of excitation profile in Zero Echo Time (ZTE) imaging using quadratic phase-modulated RF pulse excitation  and iterative reconstruction. IEEE Trans Med Imaging. 2014 Apr;33(4):961-9. 
  • Al Mukaddam M, Rajapakse CS, Bhagat YA, Wehrli FW, Guo W, Peachey H, LeBeau SO, Zemel BS, Wang C, Swerdloff RS, Kapoor SC, Snyder PJ. Effects of testosterone and growth hormone on the structural and mechanical properties of bone by micro-MRI in the distal tibia of men with hypopituitarism. J Clin Endocrinol Metab. 2014 Apr;99(4):1236-44. 
  • Jain V, Buckley EM, Licht DJ, Lynch JM, Schwab PJ, Naim MY, Lavin NA, Nicolson SC, Montenegro LM, Yodh AG, Wehrli FW. Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics. J Cereb Blood Flow Metab. 2014 Mar;34(3):380-8. 
  • Rajapakse CS, Phillips EA, Sun W, Wald MJ, Magland JF, Snyder PJ, Wehrli FW. Vertebral deformities and fractures are associated with MRI and pQCT measures obtained at the distal tibia and radius of postmenopausal women. Osteoporos Int.  2014 Mar;25(3):973-82. 
  • Glover GH, Jones DK, Frahm J, Henkelman RM, Hennig J, Maudsley AA, Riederer SJ, Wehrli FW, Bernstein MA. Magnetic resonance in medicine at 30. Magn Reson Med. 2014 Mar;71(3):901-2. 
  • Wehrli FW, Rodgers ZB, Jain V, Langham MC, Li C, Licht DJ, Magland J. Time-resolved MRI oximetry for quantifying CMRO(2) and vascular reactivity. Acad  Radiol. 2014 Feb;21(2):207-14. Review. 
  • Rajapakse CS, Chang G. Impact of body habitus on radiologic interpretations. Acad Radiol. 2014 Jan;21(1):1-2.

  • Zhang N, Magland JF, Rajapakse CS, Lam SB, Wehrli FW. Assessment of trabecular bone yield and post-yield behavior from high-resolution MRI-based nonlinear finite element analysis at the distal radius of premenopausal and postmenopausal women susceptible to osteoporosis. Acad Radiol. 2013 Dec;20(12):1584-91. 
  • Langham MC, Li C, Englund EK, Chirico EN, Mohler ER 3rd, Floyd TF, Wehrli FW.  Vessel-wall imaging and quantification of flow-mediated dilation using water-selective 3D SSFP-echo. J Cardiovasc Magn Reson. 2013 Oct 30;15:100. 
  • Englund EK, Langham MC, Li C, Rodgers ZB, Floyd TF, Mohler ER, Wehrli FW. Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg. J Cardiovasc Magn Reson. 2013 Aug19;15:70. 
  • Rebuzzi M, Vinicola V, Taggi F, Sabatini U, Wehrli FW, Capuani S. Potential diagnostic role of the MRI-derived internal magnetic field gradient in calcaneus cancellous bone for evaluating postmenopausal osteoporosis at 3T. Bone. 2013 Nov;57(1):155-63. 
  • Rodgers ZB, Jain V, Englund EK, Langham MC, Wehrli FW. High temporal resolution MRI quantification of global cerebral metabolic rate of oxygen consumption in response to apneic challenge. J Cereb Blood Flow Metab. 2013 Oct;33(10):1514-22. 
  • Zhang N, Magland JF, Rajapakse CS, Bhagat YA, Wehrli FW. Potential of in vivo MRI-based nonlinear finite-element analysis for the assessment of trabecular bone post-yield properties. Med Phys. 2013 May;40(5):052303. 
  • Seifert AC, Wright AC, Wehrli SL, Ong HH, Li C, Wehrli FW. 31P NMR relaxation of cortical bone mineral at multiple magnetic field strengths and levels of demineralization. NMR Biomed. 2013 Sep;26(9):1158-66. 
  • Langham MC, Englund EK, Mohler ER 3rd, Li C, Rodgers ZB, Floyd TF, Wehrli FW. Quantitative CMR markers of impaired vascular reactivity associated with age and peripheral artery disease. J Cardiovasc Magn Reson. 2013 Feb 13;15:17. MC3599649.
  • Wehrli FW. Magnetic resonance of calcified tissues. J Magn Reson. 2013 Apr;229:35-48. 
  • Jain V, Magland J, Langham M, Wehrli FW. High temporal resolution in vivo blood oximetry via projection-based T2 measurement. Magn Reson Med. 2013 Sep;70(3):785-90. 
  • Honig S, Rajapakse CS, Chang G. Current treatment approaches to osteoporosis. 2013. Bull Hosp Jt Dis (2013). 2013;71(3):184-8. Review. 
  • Chang G, Rajapakse CS, Diamond M, Honig S, Recht MP, Weiss DS, Regatte RR. Micro-finite element analysis applied to high-resolution MRI reveals improved bone mechanical competence in the distal femur of female pre-professional dancers. Osteoporos Int. 2013 Apr;24(4):1407-17.

  • Ong HH, Wright AC, Wehrli FW. Deuterium nuclear magnetic resonance unambiguously quantifies pore and collagen-bound water in cortical bone. J Bone Miner Res. 2012 Dec;27(12):2573-81. 
  • Magland JF, Zhang N, Rajapakse CS, Wehrli FW. Computationally-optimized bone mechanical modeling from high-resolution structural images. PLoS One. 2012;7(4):e35525. 
  • Jain V, Abdulmalik O, Propert KJ, Wehrli FW. Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification. Magn Reson Med. 2012 Sep;68(3):863-7. 
  • Li C, Magland JF, Rad HS, Song HK, Wehrli FW. Comparison of optimized soft-tissue suppression schemes for ultrashort echo time MRI. Magn Reson Med. 2012 Sep;68(3):680-9. 
  • Wald MJ, Magland JF, Rajapakse CS, Bhagat YA, Wehrli FW. Predicting trabecular bone elastic properties from measures of bone volume fraction and fabric on the basis of micromagnetic resonance images. Magn Reson Med. 2012 Aug;68(2):463-73.
  • Yan L, Li C, Kilroy E, Wehrli FW, Wang DJ. Quantification of arterial cerebral blood volume using multiphase-balanced SSFP-based ASL. Magn Reson Med. 2012 Jul;68(1):130-9. 
  • Wilhelm MJ, Ong HH, Wehrli SL, Li C, Tsai PH, Hackney DB, Wehrli FW. Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density. Proc Natl Acad Sci USA. 2012 Jun 12;109(24):9605-10. 
  • Jain V, Duda J, Avants B, Giannetta M, Xie SX, Roberts T, Detre JA, Hurt H, Wehrli FW, Wang DJ. Longitudinal reproducibility and accuracy of pseudo-continuous arterial spin-labeled perfusion MR imaging in typically developing children. Radiology. 2012 May;263(2):527-36. 
  • Chang G, Rajapakse CS, Babb JS, Honig SP, Recht MP, Regatte RR. In vivo estimation of bone stiffness at the distal femur and proximal tibia using ultra-high-field 7-Tesla magnetic resonance imaging and micro-finite element analysis. J Bone Miner Metab. 2012 Mar;30(2):243-51.
  • Li C, Langham MC, Epstein CL, Magland JF, Wu J, Gee J, Wehrli FW. Accuracy of the cylinder approximation for susceptometric measurement of intravascular oxygen saturation. Magn Reson Med. 2012 Mar;67(3):808-13. 
  • Rajapakse CS, Leonard MB, Bhagat YA, Sun W, Magland JF, Wehrli FW. Micro-MR imaging-based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation. Radiology. 2012 Mar;262(3):912-20.

  • Langham MC, Li C, Wehrli FW. Non-triggered quantification of central and peripheral pulse-wave velocity. J Cardiovasc Magn Reson. 2011 Dec 21;13:81. 12.
  • Langham MC, Wehrli FW. Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia. J Cardiovasc Magn Reson. 2011 Oct 28;13:66. 
  • Bhagat YA, Rajapakse CS, Magland JF, Wald MJ, Song HK, Leonard MB, Wehrli FW. On the significance of motion degradation in high-resolution 3D μMRI of trabecular bone. Acad Radiol. 2011 Oct;18(10):1205-16. 
  • Lam SC, Wald MJ, Rajapakse CS, Liu Y, Saha PK, Wehrli FW. Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations. Bone.2011 Oct;49(4):895-903. 
  • Langham MC, Li C, Magland JF, Wehrli FW. Nontriggered MRI quantification of aortic pulse-wave velocity. Magn Reson Med. 2011 Mar;65(3):750-5. 
  • Rad HS, Lam SC, Magland JF, Ong H, Li C, Song HK, Love J, Wehrli FW. Quantifying cortical bone water in vivo by three-dimensional ultra-short echo-time MRI. NMR Biomed. 2011 Aug;24(7):855-64.
  • Jain V, Langham MC, Floyd TF, Jain G, Magland JF, Wehrli FW. Rapid magnetic resonance measurement of global cerebral metabolic rate of oxygen consumption in humans during rest and hypercapnia. J Cereb Blood Flow Metab. 2011
  • Jul;31(7):1504-12. .
  • Wright AC, Lemdiasov R, Connick TJ, Bhagat YA, Magland JF, Song HK, Toddes SP, Ludwig R, Wehrli FW. Helmholtz-pair transmit coil with integrated receive array for high-resolution MRI of trabecular bone in the distal tibia at 7T. J Magn Reson. 2011 May;210(1):113-22. 
  • Bhagat YA, Rajapakse CS, Magland JF, Love JH, Wright AC, Wald MJ, Song HK, Wehrli FW. Performance of μMRI-Based virtual bone biopsy for structural and mechanical analysis at the distal tibia at 7T field strength. J Magn Reson Imaging. 2011 Feb;33(2):372-81. 

  • Rajapakse CS, Magland JF, Wald MJ, Liu XS, Zhang XH, Guo XE, Wehrli FW. Computational biomechanics of the distal tibia from high-resolution MR and micro-CT images. Bone. 2010 Sep;47(3):556-63. 
  • Langham MC, Jain V, Magland JF, Wehrli FW. Time-resolved absolute velocity quantification with projections. Magn Reson Med. 2010 Dec;64(6):1599-606. 
  • Wu WC, Jain V, Li C, Giannetta M, Hurt H, Wehrli FW, Wang DJ. In vivo venous blood T1 measurement using inversion recovery true-FISP in children and adults. Magn Reson Med. 2010 Oct;64(4):1140-7. 
  • Liu XS, Zhang XH, Rajapakse CS, Wald MJ, Magland J, Sekhon KK, Adam MF, Sajda P, Wehrli FW, Guo XE. Accuracy of high-resolution in vivo micro magnetic resonance imaging for measurements of microstructural and mechanical properties of human distal tibial bone. J Bone Miner Res. 2010 Sep;25(9):2039-50. .
  • Wald MJ, Magland JF, Rajapakse CS, Wehrli FW. Structural and mechanical parameters of trabecular bone estimated from in vivo high-resolution magnetic resonance images at 3 tesla field strength.  J Magn Reson Imaging. 2010 May;31(5):1157-68. 
  • Jain V, Langham MC, Wehrli FW. MRI estimation of global brain oxygen consumption rate. J Cereb Blood Flow Metab. 2010 Sep;30(9):1598-607. Erratum in: J Cereb Blood Flow Metab. 2010 Dec;30(12):1987. J Cereb Blood Flow Metab. 2011 May;31(5):1336. 
  • Ong HH, Wehrli FW. Quantifying axon diameter and intra-cellular volume fraction in excised mouse spinal cord with q-space imaging.Neuroimage. 2010 Jul 15;51(4):1360-6. 
  • Wehrli FW, Rajapakse CS, Magland JF, Snyder PJ. Mechanical implications of estrogen supplementation in early postmenopausal women. J Bone Miner Res. 2010 Jun;25(6):1406-14. 
  • Magland JF, Rajapakse CS, Wright AC, Acciavatti R, Wehrli FW. 3D fast spin echo with out-of-slab cancellation: a technique for high-resolution structural imaging of trabecular bone at 7 Tesla. Magn Reson Med. 2010 Mar;63(3):719-27.
  • Langham MC, Floyd TF, Mohler ER 3rd, Magland JF, Wehrli FW. Evaluation of cuff-induced ischemia in the lower extremity by magnetic resonance oximetry. J Am Coll Cardiol. 2010 Feb 9;55(6):598-606. 
  • Anumula S, Wehrli SL, Magland J, Wright AC, Wehrli FW. Ultra-short echo-time MRI detects changes in bone mineralization and water content in OVX rat bone in response to alendronate treatment. Bone. 2010 May;46(5):1391-9. 

  • Vasilić B, Rajapakse CS, Wehrli FW. Classification of trabeculae into three-dimensional rodlike and platelike structures via local inertial anisotropy. Med Phys. 2009 Jul;36(7):3280-91.
  • Wu WC, Mohler E 3rd, Ratcliffe SJ, Wehrli FW, Detre JA, Floyd TF. Skeletal muscle microvascular flow in progressive peripheral artery disease: assessment with continuous arterial spin-labeling perfusion magnetic resonance imaging. J Am Coll Cardiol. 2009 Jun 23;53(25):2372-7.
  • Langham MC, Magland JF, Epstein CL, Floyd TF, Wehrli FW. Accuracy and precision of MR blood oximetry based on the long paramagnetic cylinder approximation of large vessels. Magn Reson Med. 2009 Aug;62(2):333-40.
  • Rajapakse CS, Magland J, Zhang XH, Liu XS, Wehrli SL, Guo XE, Wehrli FW. Implications of noise and resolution on mechanical properties of trabecular bone  estimated by image-based finite-element analysis. J Orthop Res. 2009 Oct;27(10):1263-71.
  • Magland JF, Wald MJ, Wehrli FW. Spin-echo micro-MRI of trabecular bone using improved 3D fast large-angle spin-echo (FLASE). Magn Reson Med. 2009 May;61(5):1114-21.
  • Magland JF, Jones CE, Leonard MB, Wehrli FW. Retrospective 3D registration of  trabecular bone MR images for longitudinal studies. J Magn Reson Imaging. 2009 Jan;29(1):118-26.
  • Langham MC, Magland JF, Floyd TF, Wehrli FW. Retrospective correction for induced magnetic field inhomogeneity in measurements of large-vessel hemoglobin oxygen saturation by MR susceptometry. Magn Reson Med. 2009 Mar;61(3):626-33.

  • Li CQ, Magland JF, Rajapakse CS, Guo XE, Zhang XH, Vasilic B, Wehrli FW. Implications of resolution and noise for in vivo micro-MRI of trabecular bone. Med Phys. 2008 Dec;35(12):5584-94.
  • Magland JF, Wehrli FW. Trabecular bone structure analysis in the limited spatial resolution regime of in vivo MRI. Acad Radiol. 2008 Dec;15(12):1482-93.
  • Techawiboonwong A, Song HK, Leonard MB, Wehrli FW. Cortical bone water: in vivo quantification with ultrashort echo-time MR imaging.Radiology. 2008 Sep;248(3):824-33.
  • Rajapakse CS, Magland JF, Wehrli FW. Fast prospective registration of in vivo MR images of trabecular bone microstructure in longitudinal studies. Magn Reson Med. 2008 May;59(5):1120-6.
  • Zhang XH, Liu XS, Vasilic B, Wehrli FW, Benito M, Rajapakse CS, Snyder PJ, Guo XE. In vivo micro MRI-based finite element and morphological analyses of tibial trabecular bone in eugonadal and hypogonadal men before and after testosterone treatment. J Bone Miner Res. 2008 Sep;23(9):1426-34.
  • Ong HH, Wright AC, Wehrli SL, Souza A, Schwartz ED, Hwang SN, Wehrli FW. Indirect measurement of regional axon diameter in excised mouse spinal cord with  q-space imaging: simulation and experimental studies. Neuroimage. 2008 May 1;40(4):1619-32. do
  • Wu WC, Wang J, Detre JA, Wehrli FW, Mohler E 3rd, Ratcliffe SJ, Floyd TF. Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI. Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2129-36. Erratum in: Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H902.
  • Wehrli FW, Ladinsky GA, Jones C, Benito M, Magland J, Vasilic B, Popescu AM, Zemel B, Cucchiara AJ, Wright AC, Song HK, Saha PK, Peachey H, Snyder PJ. In vivo magnetic resonance detects rapid remodeling changes in the topology of the trabecular bone network after menopause and the protective effect of estradiol. J Bone Miner Res. 2008 May;23(5):730-40.
  • Anumula S, Magland J, Wehrli SL, Ong H, Song HK, Wehrli FW. Multi-modality study of the compositional and mechanical implications of hypomineralization in a rabbit model of osteomalacia. Bone. 2008 Feb;42(2):405-13.
  • Song R, Lin W, Chen Q, Asakura T, Wehrli FW, Song HK. Relationships between MR transverse relaxation parameters R*(2), R(2) and R'(2) and hepatic iron content in thalassemic mice at 1.5 T and 3 T. NMR Biomed. 2008 Jul;21(6):574-80.
  • Liu XS, Sajda P, Saha PK, Wehrli FW, Bevill G, Keaveny TM, Guo XE. Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone. J Bone Miner Res. 2008 Feb;23(2):223-35.
  • Ladinsky GA, Vasilic B, Popescu AM, Wald M, Zemel BS, Snyder PJ, Loh L, Song  HK, Saha PK, Wright AC, Wehrli FW. Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD. J Bone Miner Res. 2008 Jan;23(1):64-74.
  • Techawiboonwong A, Song HK, Wehrli FW. In vivo MRI of submillisecond T(2) species with two-dimensional and three-dimensional radial sequences and applications to the measurement of cortical bone water. NMR Biomed. 2008 Jan;21(1):59-70.

  • Wu WC, Fernández-Seara M, Detre JA, Wehrli FW, Wang J. A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labeling. Magn Reson Med. 2007 Nov;58(5):1020-7.
  • Uematsu H, Takahashi M, Hatabu H, Chin CL, Wehrli SL, Wehrli FW, Asakura T. Changes in T1 and T2 observed in brain magnetic resonance imaging with delivery of high concentrations of oxygen. J Comput Assist Tomogr. 2007 Sep-Oct;31(5):662-5.
  • Lin W, Ladinsky GA, Wehrli FW, Song HK. Image metric-based correction (autofocusing) of motion artifacts in high-resolution trabecular bone imaging. J Magn Reson Imaging. 2007 Jul;26(1):191-7.
  • Hopper TA, Wehrli FW, Saha PK, Andre JB, Wright AC, Sanchez CP, Leonard MB. Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. J Comput Assist Tomogr. 2007 Mar-Apr;31(2):320-8.
  • Wright AC, Bataille H, Ong HH, Wehrli SL, Song HK, Wehrli FW. Construction and calibration of a 50 T/m z-gradient coil for quantitative diffusion microimaging. J Magn Reson. 2007 May;186(1):17-25.
  • Wehrli FW. Structural and functional assessment of trabecular and cortical bone by micro magnetic resonance imaging. J Magn Reson Imaging. 2007 Feb;25(2):390-409. Review.
  •  
  • Lei T and Wehrli FW. Magnetic resonance (MR) image analysis: a statistical approach. Int J Image Graphics 2007 7(1):119-142.
  • Liu XS, Sajda P, Saha PK, Wehrli FW, Bevill G, Keaveny TM, Guo XE. Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone. J Bone Miner Res 2007 21(10) 1608-1617.
  • Wald M, Vasilic B, Saha PK, Wehrli, FW. Spatial autocorrelation and mean intercept length analysis of trabecular bone anisotropy applied to in vivo magnetic resonance imaging. Med Phys 2007 34(3):1110-1120.
  • Saha PK, Das B, Wehrli FW. An object class-uncertainty induced adaptive force and its application to a new hybrid snake. Pattern Recognition 2007 40:2656-2671.
  • Ladinsky GA, Vasilic B, Popescu AM, Wald M, Zemel BS, Snyder PJ, Loh L, Song HK, Saha PK, Wright AC, Wehrli FW.  Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD. J Bone Min Res 2008 23(1):64-74.

  • Ladinsky GA, Wehrli FW. Noninvasive assessment of bone microarchitecture by MRI. Curr Osteo Rep. 2006 Dec;4(4):140-7. Review.
  • Wehrli FW. NMR of the musculoskeletal system. NMR Biomed. 2006 Nov;19(7):721-2.
  • Takahashi M, Saha PK, Wehrli FW. Skeletal effects of short-term exposure to dexamethasone and response to risedronate treatment studied in vivo in rabbits by magnetic resonance micro-imaging and spectroscopy. J Bone Miner Metab. 2006;24(6):467-75.
  • Wehrli FW, Song HK, Saha PK, Wright AC. Quantitative MRI for the assessment of bone structure and function. NMR Biomed. 2006 Nov;19(7):731-64. Review.
  • Anumula S, Magland J, Wehrli SL, Zhang H, Ong H, Song HK, Wehrli FW. Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging. Magn Reson Med. 2006 Nov;56(5):946-52.
  • Hopper TA, Vasilić B, Pope JM, Jones CE, Epstein CL, Song HK, Wehrli FW. Experimental and computational analyses of the effects of slice distortion from a metallic sphere in an MRI phantom. Magn Reson Imaging. 2006 Oct;24(8):1077-85.
  • Liu XS, Sajda P, Saha PK, Wehrli FW, Guo XE. Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone. J Bone Miner Res. 2006 Oct;21(10):1608-17.
  • Magland J, Wehrli FW. General algorithm for automated off-center MRI. Magn Reson Med. 2006 Jul;56(1):230-3.
  • Jones CE, Wolf RL, Detre JA, Das B, Saha PK, Wang J, Zhang Y, Song HK, Wright AC, Mohler EM 3rd, Fairman RM, Zager EL, Velazquez OC, Golden MA, Carpenter JP, Wehrli FW. Structural MRI of carotid artery atherosclerotic lesion burden and characterization of hemispheric cerebral blood flow before and after carotid endarterectomy. NMR Biomed. 2006 Apr;19(2):198-208.
  • Magland J, Vasilic B, Wehrli FW. Fast low-angle dual spin-echo (FLADE): a new robust pulse sequence for structural imaging of trabecular bone. Magn Reson Med.  2006 Mar;55(3):465-71.
  • Fernandez-Seara MA,  Techawiboonwong A, Detre JA, Wehrli FW. MR Susceptometry for measuring global brain oxygen extraction. Magn Reson Med 2006 55:967–973.

  • Vasilic B, Wehrli FW. A novel local thresholding algorithm for trabecular bone volume fraction mapping in the limited spatial resolution regime of in vivo MRI.  IEEE Trans Med Imaging. 2005 Dec;24(12):1574-85.
  • Anumula S, Song HK, Wright AC, Wehrli FW. High-resolution black-blood MRI of the carotid vessel wall using phased-array coils at 1.5 and 3 Tesla. Acad Radiol. 2005 Dec;12(12):1521-6.
  • Gomberg BR, Saha PK, Wehrli FW. Method for cortical bone structural analysis from magnetic resonance images. Acad Radiol. 2005 Oct;12(10):1320-32.
  • Benito M, Vasilic B, Wehrli FW, Bunker B, Wald M, Gomberg B, Wright AC, Zemel  B, Cucchiara A, Snyder PJ. Effect of testosterone replacement on trabecular architecture in hypogonadal men. J Bone Miner Res. 2005 Oct;20(10):1785-91.
  • Lin W, Wehrli FW, Song HK. Correcting bulk in-plane motion artifacts in MRI using the point spread function. IEEE Trans Med Imaging. 2005 Sep;24(9):1170-6.
  • Zhang Y, Song HK, Wang J, Techawiboonwong A, Wehrli FW. Spatially-confined arterial spin-labeling with FAIR. J Magn Reson Imaging. 2005 Jul;22(1):119-24.
  • Bouchard LS, Wehrli FW, Chin CL, Warren WS. Structural anisotropy and internal magnetic fields in trabecular bone: coupling solution and solid dipolar interactions. J Magn Reson. 2005 Sep;176(1):27-36.
  • Wolf RL, Wehrli SL, Popescu AM, Woo JH, Song HK, Wright AC, Mohler ER 3rd, Harding JD, Zager EL, Fairman RM, Golden MA, Velazquez OC, Carpenter JP, Wehrli FW. Mineral volume and morphology in carotid plaque specimens using high-resolution MRI and CT. Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1729-35.
  • Wehrli FW, Fernández-Seara MA. Nuclear magnetic resonance studies of bone water. Ann Biomed Eng. 2005 Jan;33(1):79-86. Review.
  • Ong H, Chin CL, Wehrli SL, Tang X, Wehrli FW. A new approach for simultaneous measurement of ADC and T2 from echoes generated via multiple coherence transfer pathways. J Magn Reson. 2005 Mar;173(1):153-9.
  • Furlan PM, Ten Have T, Cary, M, Zemel B, Wehrli FW, Katz IR, Gettes, DR, Evans DL. The role of stress-induced cortisol in the relationship between depression and decreased bone mineral density. Biol Psychiatry 2005 57(8):911-7.
  • Techawiboonwong A, Song HK, Magland J, Saha PK, Wehrli, FW. Implications of pulse sequence in structural imaging of trabecular bone. J Mag Reson Imaging 2005 22:647-656.

  • Takahashi M, Wehrli FW. Micro MRI of trabecular bone. Clin Calcium. 2004 Dec;14(12):47-54. Review. Japanese.
  • Uematsu H, Popescu A, Zhang G, Wright AC, Wehrli SL, Takahashi M, Wehrli FW, Selzer ME, Hackney DB. Magnetization transfer micro-MR imaging of live excised lamprey spinal cord: characterization and immunohistochemical correlation. Am J Neuroradiol. 2004 Nov-Dec;25(10):1816-20.
  • Chin CL, Wehrli FW, Fan Y, Hwang SN, Schwartz ED, Nissanov J, Hackney DB. Assessment of axonal fiber tract architecture in excised rat spinal cord by localized NMR q-space imaging: simulations and experimental studies. Magn Reson Med. 2004 Oct;52(4):733-40.
  • Vasilic B, Song HK, Wehrli FW. Coherence-induced artifacts in large-flip-angle steady-state spin-echo imaging. Magn Reson Med. 2004 Aug;52(2):346-53.
  • Wehrli FW, Leonard MB, Saha PK, Gomberg BR. Quantitative high-resolution magnetic resonance imaging reveals structural implications of renal osteodystrophy on trabecular and cortical bone. J Magn Reson Imaging. 2004 Jul;20(1):83-9.
  • Gomberg BR, Wehrli FW, Vasilić B, Weening RH, Saha PK, Song HK, Wright AC. Reproducibility and error sources of micro-MRI-based trabecular bone structural parameters of the distal radius and tibia. Bone. 2004 Jul;35(1):266-76.
  • Zhang Y, Wehrli FW. Reference-scan-free method for automated correction of Nyquist ghost artifacts in echoplanar brain images. Magn Reson Med. 2004 Mar;51(3):621-4.
  • Fernández-Seara MA, Wehrli SL, Takahashi M, Wehrli FW. Water content measured by proton-deuteron exchange NMR predicts bone mineral density and mechanical properties. J Bone Miner Res. 2004 Feb;19(2):289-96.
  • Saha PK, Wehrli FW. Measurement of trabecular bone thickness in the limited resolution regime of in vivo MRI by fuzzy distance transform. IEEE Trans Med Imaging. 2004 Jan;23(1):53-62.
  • Wehrli FW. On the 2003 Nobel Prize in medicine or physiology awarded to Paul  C. Lauterbur and Sir Peter Mansfield. Magn Reson Med. 2004 Jan;51(1):1-3.
  • Saha PK, Wehrli FW. A robust method for measuring trabecular bone orientation anisotropy at in vivo resolution using tensor scale. Pattern Recognition 2004 37(9):1935-1944.
  • Tang XP, Chin, CL, Bouchard LS, Warren WS, Wehrli FW. Observing Bragg-like diffraction via multiple coupled nuclear spins. Phys Let A 2004 326:114-125.

  • Fernández-Seara MA, Wehrli SL, Takahashi M, Wehrli FW. Water content measured by proton-deuteron exchange NMR predicts bone mineral density and mechanical properties. J Bone Miner Res. 2004 Feb;19(2):289-96.
  • Hwang SN, Chin CL, Wehrli FW, Hackney DB. An image-based finite difference model for simulating restricted diffusion. Magn Reson Med. 2003 Aug;50(2):373-82.
  • Fernández-Seara MA, Wehrli SL, Wehrli FW. Multipoint mapping for imaging of semi-solid materials. J Magn Reson. 2003 Feb;160(2):144-50.
  • Gomberg BR, Saha PK, Wehrli FW. Topology-based orientation analysis of trabecular bone networks. Med Phys. 2003 Feb;30(2):158-68.
  • Benito M, Gomberg B, Wehrli FW, Weening RH, Zemel B, Wright AC, Song HK, Cucchiara A, Snyder PJ. Deterioration of trabecular architecture in hypogonadal men. J Clin Endocrinol Metab. 2003 Apr;88(4):1497-502.
  • Chin CL, Tang X, Bouchard LS, Saha PK, Warren WS, Wehrli FW. Isolating quantum coherences in structural imaging using intermolecular double-quantum coherence MRI. J Magn Reson. 2003 Dec;165(2):309-14.
  • Chin CL, Wehrli FW, Hwang SN, Jaggard DL, Hackney DB, Wehrli SW. Feasibility of probing boundary morphology of structured materials by 2D NMR q-space imaging. J Magn Reson. 2003 Jan;160(1):20-5.
  • Saha PK, Wehrli FW, Gomberg, BR. Fuzzy distance transform: Theory, algorithms and applications. Computer Vision Image Understanding2003 86:171-190.
  • Wehrli FW, Saha PK, Gomberg, BR, Song HK. Noninvasive assessment of bone architecture by magnetic resonance micro-imaging-based virtual bone biopsy. Proc IEEE 2003 91:1520-1542.

  • Wehrli FW, Hilaire L, Fernández-Seara M, Gomberg BR, Song HK, Zemel B, Loh L, Snyder PJ. Quantitative magnetic resonance imaging in the calcaneus and femur of women with varying degrees of osteopenia and vertebral deformity status. J Bone Miner Res. 2002 Dec;17(12):2265-73.
  • Wehrli FW, Saha PK, Gomberg BR, Song HK, Snyder PJ, Benito M, Wright A, Weening R. Role of magnetic resonance for assessing structure and function of trabecular bone. Top Magn Reson Imaging. 2002 Oct;13(5):335-55. Review.
  • Takahashi M, Hackney DB, Zhang G, Wehrli SL, Wright AC, O'Brien WT, Uematsu H, Wehrli FW, Selzer ME. Magnetic resonance microimaging of intraaxonal water diffusion in live excised lamprey spinal cord. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16192-6.
  • Bey MJ, Song HK, Wehrli FW, Soslowsky LJ. Intratendinous strain fields of the intact supraspinatus tendon: the effect of glenohumeral joint position and tendon region. J Orthop Res. 2002 Jul;20(4):869-74.
  • Bey MJ, Song HK, Wehrli FW, Soslowsky LJ. A noncontact, nondestructive method for quantifying intratissue deformations and strains. J Biomech Eng. 2002 Apr;124(2):253-8.
  • Hwang SN, Wehrli FW. Subvoxel processing: a method for reducing partial volume blurring with application to in vivo MR images of trabecular bone. Magn Reson Med. 2002 May;47(5):948-57.
  • Takahashi M, Wehrli FW, Hilaire L, Zemel BS, Hwang SN. In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4574-9.
  • Chin CL, Wehrli FW, Hwang SN, Takahashi M, Hackney DB. Biexponential diffusion attenuation in the rat spinal cord: computer simulations based on anatomic images of axonal architecture. Magn Reson Med. 2002 Mar;47(3):455-60.
  • Wright AC, Wehrli SL, Zhang G, Takahashi M, Hackney DB, Selzer ME, Wehrli FW. Visualization of individual axons in excised lamprey spinal cord by magnetic resonance microscopy. J Neurosci Methods. 2002 Feb 15;114(1):9-15.
  • Fernández-Seara MA, Wehrli SL, Wehrli FW. Diffusion of exchangeable water in cortical bone studied by nuclear magnetic resonance. Biophys J. 2002 Jan;82(1 Pt 1):522-9.
  • Song HK, Wright AC, Wolf RL, Wehrli FW. Multislice double inversion pulse sequence for efficient black-blood MRI. Magn Reson Med. 2002 Mar;47(3):616-20.

  • Gomberg BR, Saha PK, Song HK, Hwang SN, Wehrli FW. Three-dimensional digital topolgical analysis of trabecular bone. Adv Exp Med Biol. 2001;496:57-65.
  • Wehrli FW, Hwang SN, Song HK, Gomberg BR. Visualization and analysis of trabecular bone architecture in the limited spatial resolution regime of in vivo micro-MRI. Adv Exp Med Biol. 2001;496:153-64.
  • Duvvuri U, Goldberg AD, Kranz JK, Hoang L, Reddy R, Wehrli FW, Wand AJ, Englander SW, Leigh JS. Water magnetic relaxation dispersion in biological systems: the contribution of proton exchange and implications for the noninvasive detection of cartilage degradation. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12479-84.
  • Wehrli FW, Gomberg BR, Saha PK, Song HK, Hwang SN, Snyder PJ. Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. J Bone Miner Res. 2001 Aug;16(8):1520-31.
  • Fernández-Seara MA, Song HK, Wehrli FW. Trabecular bone volume fraction mapping by low-resolution MRI. Magn Reson Med. 2001 Jul;46(1):103-13.
  • Allen RP, Barker PB, Wehrli FW, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless leg syndrome. Neurol. 2001 56:263-265.

  • Wehrli FW, Hopkins JA, Hwang SN, Song HK, Snyder PJ, Haddad JG. Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry. Radiology. 2000 Nov;217(2):527-38.
  • Hilaire L, Wehrli FW, Song HK. High-speed spectroscopic imaging for cancellous bone marrow R(2)* mapping and lipid quantification. Magn Reson Imaging. 2000 Sep;18(7):777-86.
  • Fernández-Seara MA, Wehrli FW. Postprocessing technique to correct for background gradients in image-based R*(2) measurements. Magn Reson Med. 2000 Sep;44(3):358-66.
  • Gomberg BR, Saha PK, Song HK, Hwang SN, Wehrli FW. Topological analysis of trabecular bone MR images. IEEE Trans Med Imaging. 2000 Mar;19(3):166-74.
  • Wright AC, Song HK, Wehrli FW. In vivo MR micro imaging with conventional radiofrequency coils cooled to 77 degrees K. Magn Reson Med.2000 Feb;43(2):163-9.
  • Takahashi M, Wehrli FW, Hwang SN, Wehrli SL. Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model. Magn Reson Imaging. 2000 Jan;18(1):33-9.
  • Saha PK, Gomberg BG, Wehrli FW. Three-dimensional digital topological characterization of cancellous bone architecture. Int J Imaging Systems Technol 2000 11:81-90.

  • Hwang SN, Wehrli FW. Experimental evaluation of a surface charge method for computing the induced magnetic field in trabecular bone. J Magn Reson. 1999 Jul;139(1):35-45.
  • Song HK, Wehrli FW. In vivo micro-imaging using alternating navigator echoes with applications to cancellous bone structural analysis. Magn Reson Med. 1999 May;41(5):947-53.
  • Takahashi M, Wehrli FW, Wehrli SL, Hwang SN, Lundy MW, Hartke J, Borah B. Effect of prostaglandin and bisphosphonate on cancellous bone volume and structure in the ovariectomized rat studied by quantitative three-dimensionalb nuclear magnetic resonance microscopy. J Bone Miner Res. 1999 May;14(5):680-9.
  • Hwang SN, Wehrli FW. Estimating voxel volume fractions of trabecular bone on the basis of magnetic resonance images acquired in vivo. Int J Imaging Sys Technol 1999 10:186-198.

  • Wehrli FW, Hwang SN, Song HK. New architectural parameters derived from micro-MRI for the prediction of trabecular bone strength. Technol Health Care. 1998 Dec;6(5-6):307-20. Review.
  • Wehrli FW, Ma J, Hopkins JA, Song HK. Measurement of R'2 in the presence of multiple spectral components using reference spectrum deconvolution. J Magn Reson. 1998 Mar;131(1):61-8.
  • Song HK, Wehrli FW. Variable TE gradient and spin echo sequences for in vivo MR microscopy of short T2 species. Magn Reson Med. 1998 Feb;39(2):251-8.
  • Wehrli FW, Hwang SN, Ma J, Song HK, Ford JC, Haddad JG. Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing. Radiology. 1998 Feb;206(2):347-57. Erratum in: Radiology 1998 Jun;207(3):833.

  • Hwang SN, Wehrli FW, Williams JL. Probability-based structural parameters from three-dimensional nuclear magnetic resonance images as predictors of trabecular bone strength. Med Phys. 1997 Aug;24(8):1255-61.
  • Hopkins JA, Wehrli FW. Magnetic susceptibility measurement of insoluble solids by NMR: magnetic susceptibility of bone. Magn Reson Med. 1997 Apr;37(4):494-500.
  • Ma J, Wehrli FW, Song HK, Hwang SN. A single-scan imaging technique for measurement of the relative concentrations of fat and water protons and their transverse relaxation times. J Magn Reson. 1997 Mar;125(1):92-101.
  • Song HK, Wehrli FW, Ma J. Field strength and angle dependence of trabecular bone marrow transverse relaxation in the calcaneus. J Magn Reson Imaging. 1997 Mar-Apr;7(2):382-8.
  • Song HK, Wehrli FW, Ma J. In vivo MR microscopy of the human skin. Magn Reson Med. 1997 Feb;37(2):185-91.

  • Ma J, Wehrli FW. Method for image-based measurement of the reversible and irreversible contribution to the transverse-relaxation rate. J Magn Reson B. 1996 Apr;111(1):61-9.
  • Ma J, Wehrli FW, Song HK. Fast 3D large-angle spin-echo imaging (3D FLASE). Magn Reson Med. 1996 Jun;35(6):903-10.
  • Chung HW, Hwang SN, Yeung HN, Wehrli FW. Mapping of the magnetic-field distribution in cancellous bone. J Magn Reson B. 1996 Nov;113(2):172-6.
  • Ma J, Wehrli FW, Song H.  A single-scan imaging technique for quantitation of the relative contents of fat and water protons and their transverse relaxation times. J Magn Reson 125:92-101; 1996.

  • Wehrli FW, Ford JC, Haddad JG. Osteoporosis: clinical assessment with quantitative MR imaging in diagnosis. Radiology. 1995 Sep;196(3):631-41.
  • Chung HW, Wehrli FW, Williams JL, Kugelmass SD, Wehrli SL. Quantitative analysis of trabecular microstructure by 400 MHz nuclear magnetic resonance imaging. J Bone Miner Res. 1995 May;10(5):803-11.
  • Chung HW, Wehrli FW, Williams JL, Wehrli SL. Three-dimensional nuclear magnetic resonance microimaging of trabecular bone. J Bone Miner Res. 1995 Oct;10(10):1452-61.
  • Hwang SN, Wehrli FW.  The calculation of the susceptibility-induced magnetic field from 3D NMR images with applications to trabecular bone. J Magn Res Ser B 1995 109:126-145.

  • Chung H, Wehrli FW, Williams JL, Kugelmass SD. Relationship between NMR transverse relaxation, trabecular bone architecture, and strength. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10250-4.
  • Ford JC, Wehrli FW, Chung HW. Magnetic field distribution in models of trabecular bone. Magn Reson Med. 1993 Sep;30(3):373-9.
  • Jara H, Wehrli FW, Chung H, Ford JC. High-resolution variable flip angle 3D MR imaging of trabecular microstructure in vivo. Magn Reson Med. 1993 Apr;29(4):528-39.
  • Wehrli FW, Ford JC, Chung HW, Wehrli SL, Williams JL, Grimm MJ, Kugelmass SD, Jara H. Potential role of nuclear magnetic resonance for the evaluation of trabecular bone quality. Calcif Tissue Int. 1993;53 Suppl 1:S162-9. Review.

  • Jara H, Wehrli FW. Determination of background gradients with diffusion MR imaging. J Magn Reson Imaging. 1994 Nov-Dec;4(6):787-97.
  • Chung HW, Chu CC, Underweiser M, Wehrli FW. On the fractal nature of trabecular structure. Med Phys. 1994 Oct;21(10):1535-40.
  • Wu Z, Chung HW, Wehrli FW. A Bayesian approach to subvoxel tissue classification in NMR microscopic images of trabecular bone. Magn Reson Med. 1994 Mar;31(3):302-8.