Our lab focuses on the developmental pathways and factors that are critical for building the cardiopulmonary system. Using a combination of mouse genetics, biochemistry, and genomic analysis, we seek to better understand how the lung and heart develop, how developmental pathways are disrupted in human cardiopulmonary disease, and whether such pathways and factors can be harnessed to promote pulmonary and cardiac regeneration in the adult.
Recent Lab News
Congratulations to Dr. David Frank! He has accepted a Full-Time Faculty position at Department of Pediatrics, Attending Physician, Children's Hospital of Philadelphia, University of Pennsylvania.
We have recently demonstrated the emergence of a Wnt-responsive alveolar epithelial cell sublineage that arises during alveologenesis called the axin2+ alveolar type 2 cell or AT2Axin2. There was a threshold of Wnt signaling required to maintain the AT2 fate, and an additional increase in Wnt signaling only promoted AT2 cell proliferation.