The Morrisey Lab is comprised of a group of researchers dedicated to investigating cell fate decisions that occur in the lung during development, tissue homeostasis, and regeneration. We utilize cutting edge technologies including sing cell -omics, novel transgenic mouse models, advanced imaging techniques, and custom bioinformatics platforms to expand our understanding of how the respiratory system responds to acute and chronic disease and injury.

Our lab is composed of a highly collaborative team of graduate students, postdocs, physician-scientists, technicians, staff scientists, and a bioinformatics team.  Former Morrisey lab trainees are emerging as the next generation of leaders in pulmonary research and medicine. We invite you to view our webpage and learn more about us, also follow @MorriseyLab on Twitter.

Lab picture 2023


Penn-CHOP Lung Biology Institute (LBI) 

Lung diseases, both congenital and those acquired throughout life, continue to be among the top causes of mortality and morbidity in the US and the number of people affected by these diseases continues to grow each year. The Penn-CHOP Lung Biology Institute (LBI) was formed to fulfill the growing demand for enhanced early detection capabilities and the development of more efficacious treatment options for both adult and pediatric lung diseases. The LBI is led by Dr. Edward E. Morrisey, and unites the resources, faculty and innovation of the Hospital of the University of Pennsylvania, the Department of Medicine at UPenn and the Children’s Hospital of Philadelphia to apply basic developmental research findings to inspire new state of the art approaches for increasing our understanding and treating patients affected by lung diseases. The LBI also provides access to high quality human lung tissue and genomic analysis of existing and newly generated large scale sequencing data sets of human and mouse models of lung diseases. For more information please visit the LBI website.

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Recent Lab News

Congratulations to Dr. Kazushige Shiraishi on his publication on NPJ Regenerative Medicine. “Airway epithelial cell identity and plasticity are constrained by Sox2 during lung homeostasis, tissue regeneration, and in human disease”. NPJ Regen Med. 2024 Jan 5;9(1):2. doi: 10.1038/s41536-023-00344-w.


Congratulations to Dr. Terren Neithamer starting her own lab at NIH in Jan 2024!


Congratulations to Dr. Shanru Li on his research project  published on Stem Cell Reports. “DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury”. Stem Cell Reports. 2023 Sep 12;18(9):1841-1853. doi: 10.1016/j.stemcr.2023.07.006. Epub 2023 Aug 17.


Congratulations to Dr. Maria Basil to establish her lab at UPenn in July 2023!