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The Morrisey Lab is comprised of a group of researchers dedicated to investigating cell fate decisions that occur in the lung during development, tissue homeostasis, and regeneration. We utilize cutting edge technologies including sing cell -omics, novel transgenic mouse models, advanced imaging techniques, and custom bioinformatics platforms to expand our understanding of how the respiratory system responds to acute and chronic disease and injury.
Our lab is composed of a highly collaborative team of graduate students, postdocs, physician-scientists, technicians, staff scientists, and a bioinformatics team. Former Morrisey lab trainees are emerging as the next generation of leaders in pulmonary research and medicine. We invite you to view our webpage and learn more about us, also follow @MorriseyLab on Twitter.
Penn-CHOP Lung Biology Institute (LBI)
Lung diseases, both congenital and those acquired throughout life, continue to be among the top causes of mortality and morbidity in the US and the number of people affected by these diseases continues to grow each year. The Penn-CHOP Lung Biology Institute (LBI) was formed to fulfill the growing demand for enhanced early detection capabilities and the development of more efficacious treatment options for both adult and pediatric lung diseases. The LBI is led by Dr. Edward E. Morrisey, and unites the resources, faculty and innovation of the Hospital of the University of Pennsylvania, the Department of Medicine at UPenn and the Children’s Hospital of Philadelphia to apply basic developmental research findings to inspire new state of the art approaches for increasing our understanding and treating patients affected by lung diseases. The LBI also provides access to high quality human lung tissue and genomic analysis of existing and newly generated large scale sequencing data sets of human and mouse models of lung diseases. For more information please visit the LBI website.
Recent Lab News
Congratulations to Dr. Joe Planer! He is awarded the Parker B Francis Fellowship!
Congratulations to Dr. Terren Neithamer and Dr. Joe Planer on their publication on Cell Stem Cell. “Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states.”. Cell Stem Cell. 2025 Feb 6;32(2):302-321.e6. doi: 10.1016/j.stem.2024.12.002.
Congratulations to Dr. Dakota Jones on his research project published on Science. “An injury-induced mesenchymal-epithelial cell niche coordinated regenerative responses in the lung”. Science. 2024 Dec 13;386(6727):eado5561. doi: 10.1126/science.ado5561. Epub 2024 Dec 13.
Congratulations to Dr. Dakota Jones! He is awarded the K99/R00 grant from NIH!!
Congratulations to Dr. Danielle Callaway starting her own lab at UT Southwestern Medical Center in Sept 2024!
Dr. Jonathan Knowlton is awarded the Marshall Klaus Neonatal-Perinatal Research Award, Congratulations, Jon!
Congratulations to Dr. Danielle Callaway on her publication on J Clin Invest. “TGF-B controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription in mice”. J Clin Invest. 2024 Jan 11;134(6):e172095. doi: 10.1172/JCI172095.