Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis

Summary: This was the largest international clinical trial performed in AAV (GPA and MPA). The study found that the use of plasma exchange does not improve survival or risk of end-stage renal disease. Compared to standard doses of prednisone, a more rapid taper of prednisone is just as effective and safer (fewer serious infections) than plasma exchange.

Participating Penn Investigator(s): Dr. Peter Merkel

Journal: New England Journal of Medicine, 2020. View Publication.

Disease(s): Granulomatosis with Polyangiitis (GPA), Microscopic Polyangiitis (MPA)