Microcirculation in Shock
Principal Investigator: John C. Greenwood, MD, MSTR
Email: john.greenwood@pennmedicine.upenn.edu
John Greenwood is an Assistant Professor in the Departments Emergency Medicine & Anesthesiology and Critical Care at the University of Pennsylvania. He studied Medicine at Jefferson Medical College and completed residency in Emergency Medicine at the University of Maryland where he also served as Chief Resident and Faculty Development fellow during that time. John then stayed at the University of Maryland to complete his fellowship in Critical Care Medicine, with additional training in ECMO support.
His research interests are focused on circulatory shock, resuscitation, tissue perfusion, and microcirculatory function, with a goal to improve therapeutic interventions and patient outcomes from acute critical illnesses.
John Greenwood's Recent Publications
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Advancing Microcirculation Research in Advanced Heart Failure: The Case for Methodologic Consensus.
JACC. Advances. 2026 Aug 15;5(9):103148; Authors: Greenwood JC, Wald JW, Schurr JW -
Mitochondrial Dysfunction, Cerebral Metabolic Crisis, and Exploratory Bioenergetic Biomarkers in a Translational Swine Model of Acute Carbon Monoxide Poisoning.
Toxicological sciences : an official journal of the Society of Toxicology. 2026 Jul 29; Authors: Insana A, Lewis A, Greenwood JC, Kelly M, Shofer FS, Kao SH, Mason M, Baak S, Starr J, Cabrera J, Ehinger JK, Kilbaugh TJ, Ko T, Viaene AN, Baker WB, Jang DH -
Dose-dependent cerebral metabolic impairment in a swine model of carbon monoxide poisoning.
Neurotoxicology. 2026 May;114:103454 Epub 2026 Apr 17; Authors: Lewis A, Forti RM, Ko TS, Greenwood JC, Kelly M, Shofer FS, Kao SH, Shin SS, Bungatavula D, Mason M, Starr J, Ehinger JK, Kilbaugh TJ, Yodh AG, Baker WB, Jang DH -
Timing of inotropic support is associated with mortality in patients with acute decompensated heart failure-associated cardiogenic shock.
Intensive care medicine experimental. 2025 Oct 31;13(1):111; Authors: Greenwood JC, Ratnayake C, Shabbir M, Opitz S, Jang DH, Choi WJ, Panebianco NL, Shofer FS, Augoustides JGT, Bakker J, Wald JW, Abella BS -
Observational Study of Sublingual Microcirculation in Patients With Chronic Cardiovascular Disease.
Microcirculation (New York, N.Y. : 1994). 2025 Oct;32(7):e70032; Authors: Niculcea J, Schurr JW, Talebi FM, Wald JW, Greenwood JC -
Attenuation of mitochondrial dysfunction in a ventricular fibrillation swine model of cardiac arrest treated with carbon monoxide.
Resuscitation. 2025 Aug;213:110647 Epub 2025 May 16; Authors: Ko TS, Greenwood JC, Morgan RW, Abella BS, Shofer FS, Mason M, Weintraub D, Bungatavula D, Lewis A, Ranieri NR, Yodh AG, Baker WB, Forti RM, Kao SH, Shin SS, Kilbaugh TJ, Jang DH -
Blood Cells as a Cellular Biomarker for Mitochondrial Function in a Experimental Model of Acute Carbon Monoxide Poisoning with Treatment.
Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2025 Jul;21(3):327-335 Epub 2025 Apr 28; Authors: Bungatavula D, Greenwood JC, Shofer FS, Buehler G, Kao SH, Kelly M, Shin SS, Ehinger JK, Kilbaugh TJ, Jang DH -
Hyperkalemia-Induced Bradydysrhythmias.
Journal of acute medicine. 2025 Jun 1;15(2):43-51; Authors: Mattu A, Hayes BD, Martinez JP, Brady WJ, Greenwood JC -
The application of cell-free DNA methylation patterns in critical illnesses: A protocol paper.
PloS one. 2025;20(5):e0321626 Epub 2025 May 12; Authors: Kao SH, Stumpf KG, Gaudio HA, Greenwood JC, Shin SS, Shofer FS, Jang DH -
Laypersons frequently ask questions during adult basic life support trainings: Qualitative study.
Resuscitation plus. 2025 Mar;22:100914 Epub 2025 Feb 25; Authors: Fijačko N, Brothers T, Greenwood JC, Glick J, Abella BS