Supporting RVCL Research at Penn

We are grateful to our patients with RVCL, as well as their families and friends, for supporting our search for a cure.

We are currently conducting a multicenter clinical trial and developing novel therapies that target the TREX1 gene and protein.  We are hopeful that our efforts, with your support, will eventually lead to a cure for RVCL. Since RVCL is caused by a single gene mutation, we expect that it will be possible to cure RVCL.

• Please click here to give directly online.

• To donate by check, please make check payable to Penn Medicine and include “Penn RVCL Center” on an enclosed note or the memo line. Checks should be mailed to: Penn Medicine Development c/o Allyse Orsini, 3535 Market Street, Suite 750, Philadelphia, PA 19104

If you are interested in supporting the RVCL Research Center at Penn, you can also contact Allyse Orsini, Senior Director of Development, Penn Medicine Development and Alumni Relations.

Learn more by exploring these links:

• What is RVCL?

• The Search for a Cure

• Our Team

• Families and Registry

• Giving

* RVCL or RVCL-S stands for retinal vasculopathy with cerebral leukoencephalopathy (and systemic manifestations), also known as retinal vasculopathy with cerebral leukodystrophy, cerebroretinal vasculopathy (CRV), or hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS).