Supporting RVCL Research at Penn

We are grateful to our patients with RVCL, as well as their families and friends, for supporting our search for a cure.

We are currently conducting a multicenter clinical trial and developing novel therapies that target the TREX1 gene and protein.  We are hopeful that our efforts, with your support, will eventually lead to a cure for RVCL. Since RVCL is caused by a single gene mutation, we expect that it will be possible to cure RVCL.

• Please click here to give directly online.

• To donate by check, please make check payable to Penn Medicine and include “Penn RVCL Center” on an enclosed note or the memo line. Checks should be mailed to: Penn Medicine Development c/o Allyse Orsini, 3535 Market Street, Suite 750, Philadelphia, PA 19104.

Learn more by exploring these links:

• What is RVCL?

• The Search for a Cure

• Our Team

• Families and Registry

• Giving

* RVCL or RVCL-S stands for retinal vasculopathy with cerebral leukoencephalopathy (and systemic manifestations), also known as retinal vasculopathy with cerebral leukodystrophy, cerebroretinal vasculopathy (CRV), or hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS).