Nature magazine

Nature, Published online: 10 April 2026; doi:10.1038/d41586-026-00195-7

When I found out that I was no longer eligible for an early-career grant, I took a moment to pause and reflect on my family life and my work.

Nature, Published online: 10 April 2026; doi:10.1038/d41586-026-01063-0

The past is a foreign country.

Nature, Published online: 10 April 2026; doi:10.1038/d41586-026-01208-1

Nature correspondent Alexandra Witze tells us about being in NASA’s scientific nerve centre.

Nature, Published online: 10 April 2026; doi:10.1038/d41586-026-01160-0

Andrew Robinson reviews five of the best science picks.

Nature, Published online: 10 April 2026; doi:10.1038/s41586-026-10484-w

Author Correction: Multi-omic profiling reveals age-related immune dynamics in healthy adults

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01138-y

Nature correspondent Alexandra Witze describes the joy and tension at mission control in Houston.

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-00550-8

Sonali Majumdar offers a toolkit to support international scientists, their supervisors and mentors.

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01147-x

Repository would require US universities to register research fraud and workplace harassment.

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01120-8

Small changes in the non-coding part of the genome have a key role in sex determination.

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01108-4

Fourteen months after treatment with engineered immune cells, the recipient has no symptoms and doesn’t need to take medication.

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01207-2

‘Partial reprogramming’, which winds back a cell’s biological clock, could enter clinical trials later this year. Plus, a single DNA tweak can make female mice grow testes and why obesity drugs are more effective in some people than others.

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01111-9

Nasal tissue harbours T cells that ‘remember’ a pathogen long after infection is past.

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01109-3

High-speed cameras can observe the strange behaviour of a cornstarch–water mixture.

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01110-w

Vehicle-to-grid technology, if installed properly, could allow vehicles to serve as back-up batteries.

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01112-8

3D-printed discs harness a previously overlooked feature of bacterial locomotion to power tiny motors.

Nature, Published online: 09 April 2026; doi:10.1038/s41586-026-10486-8

Ambiphilic cross-coupling with aryl-bismuth reagents

Nature, Published online: 09 April 2026; doi:10.1038/d41586-026-01121-7

More than 40% of traded mammal species share at least one pathogen with humans, compared with only 6% of non-traded mammals.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9

A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor to reactivate fetal haemoglobin production, led to early and enduring transfusion independence in patients with β-thalassaemia.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10330-z

Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10307-y

A mummified fossil of the early Permian reptile Captorhinus reveals the potential ancestral amniote breathing mechanism and its impact on terrestrial vertebrate evolution.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10316-x

A single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental tissue architectures and transcriptional programmes, and identifies cell types with roles in pre-eclampsia, spontaneous preterm birth and miscarriage.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10168-5

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01025-6

Lab-grown organoids are turbo-charging the study of human brain development and disease.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10356-3

A robust composite pair-exchange gate based on controlled interactions of fermionic atoms in an optical superlattice demonstrates high fidelities and long Bell-state lifetimes, marking an important step towards a fully digital fermionic quantum computer.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01140-4

AI chatbots informed users of the symptoms of ‘bixonimania’ after scientists published just two fake preprints. Plus, different psychedelics work in surprisingly similar ways and an influential report on the economic cost of climate change revisited.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00812-5

New cancer therapies are needed that do not harm healthy tissue. An engineered DNA sequence shows promise as one of the tools in a method to target brain tumour cells.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01039-0

Supply and demand.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00630-9

The latest value for the mass of a fundamental particle called the W boson is consistent with the standard model of particle physics, challenging a previous anomalous result.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01021-w

The potential benefits of organoids for fundamental research and medicine are huge. Efforts to establish proper boundaries for their use should be supported.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00905-1

Genetic variants in GLP1R and GIPR, which encode targets of GLP-1-based medications, offer insights into why responses to these drugs vary and who might face adverse effects.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10329-6

Synthetic super-enhancers enable specific delivery of anticancer payloads, achieving tumour elimination after a single dose in a mouse model of aggressive glioblastoma.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10361-6

Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10326-9

The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for motifs that govern cell-type-specific transcription factor binding and chromatin accessibility during human development.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10277-1

This Perspective reviews the potential and the challenges of metabolomics approaches, encompassing both single-cell and population-scale metabolomics.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10457-z

Author Correction: Foundation model of neural activity predicts response to new stimulus types

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10345-6

Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10488-6

Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10352-7

Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and superconducting behaviour. .

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01132-4

Nature staff discuss some of the week’s top science news.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01032-7

The abundance of viral DNA was measured in DNA sequenced from blood and saliva samples in biobanks, revealing strong correlations with age, sex and dozens of genetic variants. Genetic analyses indicate that a high abundance of latent Epstein–Barr virus is a causal risk factor for a blood cancer called Hodgkin’s lymphoma.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10339-4

Large-scale lattice quantum chromodynamics simulations enable a model-free, highly precise determination of the strong coupling constant αs, reducing theoretical uncertainty and improving precision tests of particle physics.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00224-5

A popular online game simulates life as an academic — and throws the challenges of being an early-career researcher into sharp relief.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10346-5

Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart failure.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00811-6

Forests that regrow on farmland are resilient and regain much of their lost biodiversity and species richness in 30 years — a finding with implications for conservation.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10365-2

Assessment of how 16 taxonomic groups in a lowland tropical forest resist and recover from anthropogenic disturbance shows the potential of protecting naturally regenerating secondary forests to reverse biodiversity losses.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01107-5

Study of almost 28,000 people also identifies genetic variants that raise the risk of gastrointestinal side effects from GLP-1 medications.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10285-1

A purely geometric two-qubit SWAP gate can be realized by transiently populating qubit doublon states of fermionic atoms in a dynamical optical lattice.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00960-8

An appetite for scientists reflects evolution in how video-game companies think about design.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10334-9

Saturation genome editing of RNU4-2 identifies the functional and clinical impact of variants across the entire gene and delineates variants that cause a new recessive neurodevelopmental disorder distinct from ReNU syndrome.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01013-w

The Artemis II mission is a success for the European Space Agency, as well as for NASA. Will Europe crew its own lunar missions?

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10349-2

Across 17 forest plots (2.7 million trees, 5,400 species), competition dominated overall, but facilitation was relatively stronger near the equator and declined towards higher latitudes, partly linked to temperature, legumes, mycorrhizal associations and canopy nursing effect.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01037-2

The placenta — a temporary organ of the offspring — attaches to the mother’s uterus, from which it taps a blood supply. A high-resolution map of individual cells at this junction now reveals some of the specific cell–cell interactions involved and pinpoints cell types that are vulnerable in common pregnancy complications.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10337-6

An in vitro toolkit for studying VSG diversification defines key molecular requirements underlying the formation of mosaic VSGs, providing an experimental framework for the exploration of antigen diversification in Trypanosoma brucei and in other pathogenic microorganisms.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10260-w

Daily satellite data reveal that Earth’s artificial lights at night are highly volatile, with frequent brightening and dimming between 2014 and 2022.

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01053-2

Hundreds of scans hint at how substances such as psilocybin, LSD and ayahuasca alter connections between key areas of the brain.

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-00913-1

The problem of page numbering in reprinted articles, and experiments to find the source of a typhoid outbreak, in our weekly dip into Nature’s archive.

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01029-2

Scientists are exposing the biological information hidden in ancient parchments without leaving a mark.

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01024-7

A burgeoning field is launching its first clinical trial to find out whether dialling back cell development can safely refresh aged tissues and organs.

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01118-2

Images snapped during a fly-by capture a solar eclipse and unprecedented details of the far side of the Moon.

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01125-3

Nature correspondent Alexandra Witze takes over Nature Briefing for a special edition from mission control in Houston.

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01016-7

Mutations in the KRAS protein were once deemed ‘undruggable’. Today, various approaches are in the pipeline.

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01093-8

Don’t rush use of lymphatic surgery in Alzheimer’s disease

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01095-6

Representation without power in science isn’t equity

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01020-x

The landmark Stern Review, published 20 years ago, laid bare the economic cost of climate inaction. A fracturing political consensus now risks accruing even heftier bills for future generations.

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01100-y

Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?

Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01094-7

AI and the human mind: only one is a black box

Nature, Published online: 06 April 2026; doi:10.1038/d41586-026-00989-9

Nature was in Houston with the mission’s scientists when humans observed parts of the Moon’s far side by eye for the first time.

Nature, Published online: 06 April 2026; doi:10.1038/d41586-026-01027-4

A goal-driven approach to medical research and development in the United States would address unmet medical needs, reduce costs and improve the reach of treatments.

Nature, Published online: 06 April 2026; doi:10.1038/d41586-026-01026-5

As oil and gas markets face crisis, an influential economist sets out a path to a more efficient, prosperous and sustainable world.

Nature, Published online: 06 April 2026; doi:10.1038/d41586-026-01028-3

Some researchers use verse to visualize complex problems or translate the wonders of science for wider audiences.

Nature, Published online: 04 April 2026; doi:10.1038/d41586-026-01103-9

Mission scientists spoke to Nature about the geological features they’re most excited about the crew observing.

Nature, Published online: 03 April 2026; doi:10.1038/d41586-026-01105-7

The 2027 budget proposal would curb federal payments for scientific publishing and reduce funding for many US institutions.

Nature, Published online: 02 April 2026; doi:10.1038/d41586-026-01051-4

As humanity blasts off into a new space race, we need a model of exploration that emphasizes stewardship of other worlds, not exploitation.

Nature, Published online: 02 April 2026; doi:10.1038/d41586-026-01060-3

We take a look at the mission’s aims and the science that’ll be happening along the way.

Nature, Published online: 02 April 2026; doi:10.1038/d41586-026-01000-1

Study of more than 11,000 women found that only a few hours of moderate-to-vigorous activity per week had a strong effect.