Perelman School of Medicine at the University of Pennsylvania

Susztak Lab

Publications

2017

  1. Bhagat TD, Zou Y, Huang S, Park J, Palmer MB, Hu C, Li W, Shenoy N, Giricz O, Choudhary G, Yu Y, Ko YA, Izquierdo MC, Park AS, Vallumsetla N, Laurence R, Lopez R, Suzuki M, Pullman J, Kaner J, Gartrell B, Hakimi AA, Greally JM, Patel B, Benhadji K, Pradhan K, Verma A, Susztak K. Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer. J Biol Chem. 2017 Jan 20;292(3):837-846. doi: 10.1074/jbc.M116.745208. Epub 2016 Dec 1. PubMed PMID: 27909050.
  2. Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V. Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1. J Biol Chem. 2017 Jan 13;292(2):732-747. doi: 10.1074/jbc.M116.753822. Epub 2016 Dec 2. PubMed PMID: 27913625.
  3. Breyer MD, Susztak K. Developing Treatments for Chronic Kidney Disease in the 21st Century. Semin Nephrol. 2016 Nov;36(6):436-447. doi: 10.1016/j.semnephrol.2016.08.001. Review. PubMed PMID: 27987541.
  4. Li M, Carey J, Cristiano S, Susztak K, Coresh J, Boerwinkle E, Kao WH, Beaty TH, Köttgen A, Scharpf RB. Genome-Wide Association of Copy Number Polymorphisms and Kidney Function. PLoS One. 2017 Jan 30;12(1):e0170815. doi: 10.1371/journal.pone.0170815. eCollection 2017. PubMed PMID: 28135296.
  5. Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K. Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nat Med. 2017 Apr;23(4):429-438. doi: 10.1038/nm.4287. Epub 2017 Feb 20. PubMed PMID: 28218918.
  6. Gluck C, Ko YA, Susztak K. Precision Medicine Approaches to Diabetic Kidney Disease: Tissue as an Issue. Curr Diab Rep. 2017 May;17(5):30. doi: 10.1007/s11892-017-0854-7. Review.PubMed PMID: 28364354.
  7. Heymann J, Winkler CA, Hoek M, Susztak K, Kopp JB. Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte. Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i65-i70. doi: 10.1093/ndt/gfw402. PubMed PMID: 28391347.
  8. Scerbo D, Son NH, Sirwi A, Zeng L, Sas KM, Cifarelli V, Schoiswohl G, Huggins LA, Gumaste N, Hu Y, Pennathur S, Abumrad NA, Kershaw EE, Hussain MM, Susztak K, Goldberg IJ. Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids. J Lipid Res. 2017 Apr 12. pii: jlr.M074427. doi: 10.1194/jlr.M074427. PubMed PMID: 28404638.

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2016

  1. Breyer MD, Susztak K. Developing Treatments for Chronic Kidney Disease in the 21st Century. Semin Nephrol. 2016 Nov;36(6):436-447. doi: 10.1016/j.semnephrol.2016.08.001. Review. PubMed PMID: 27987541.
  2. Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh K, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V. Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via upregulation of erbb4 and notch-1. J Biol Chem. 2016 Dec 2. pii: jbc.M116.753822. [Epub ahead of print] PubMed PMID: 27913625.
  3. Bhagat TD, Zou Y, Huang S, Park J, Palmer MB, Hu C, Li W, Shenoy N, Giricz O, Choudhary G, Yu Y, Ko YA, Izquierdo MC, Park AS, Vallumsetla N, Laurence R, Lopez R, Suzuki M, Pullman J, Kaner J, Gartrell B, Hakimi AA, Greally JM, Patel B, Benhadji K, Pradhan K, Verma A, Susztak K. Notch pathway is activated via genetic and epigenetic alterations and is a therapeutic target in clear cell renal cancer. J Biol Chem. 2016 Dec 1. pii: jbc.M116.745208. [Epub ahead of print] PubMed PMID: 27909050.
  4. Li SY, Susztak K. The long noncoding RNA Tug1 connects metabolic changes with kidney disease in podocytes. J Clin Invest. 2016 Nov 1;126(11):4072-4075. doi: 10.1172/JCI90828. PubMed PMID: 27760046; PubMed Central PMCID: PMC5096895.
  5. Breyer MD, Susztak K. The next generation of therapeutics for chronic kidney disease. Nat Rev Drug Discov. 2016 Aug;15(8):568-88. doi: 10.1038/nrd.2016.67. PubMed PMID: 27230798.
  6. Akchurin O, Du Z, Ramkellawan N, Dalal V, Han SH, Pullman J, Müsch A, Susztak K, Reidy KJ. Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development. J Am Soc Nephrol. 2016 Dec;27(12):3725-3737. PubMed PMID: 27185860; PubMed Central PMCID: PMC5118470.
  7. Edeling M, Ragi G, Huang S, Pavenstädt H, Susztak K. Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog. Nat Rev Nephrol. 2016 Jul;12(7):426-39. doi: 10.1038/nrneph.2016.54. Review. PubMed PMID: 27140856.
  8. Li SY, Susztak K. Fat Burning Problem in Cystic Kidneys: an Emerging Common Mechanism of Chronic Kidney Disease. EBioMedicine. 2016 Feb 23;5:22-3. doi: 10.1016/j.ebiom.2016.02.035. PubMed PMID: 27077105; PubMed Central PMCID: PMC4816831.
  9. Lin JS, Susztak K. Podocytes: the Weakest Link in Diabetic Kidney Disease? Curr Diab Rep. 2016 May;16(5):45. doi: 10.1007/s11892-016-0735-5. Review. PubMed PMID: 27053072; PubMed Central PMCID: PMC5064850.
  10. Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A, Dieffenbach AK, Zonderman AB, Nolte IM, van der Most PJ, Wright AF, Shuldiner AR, Morrison AC, Hofman A, Smith AV, Dreisbach AW, Franke A, Uitterlinden AG, Metspalu A, Tonjes A, Lupo A, Robino A, Johansson Å, Demirkan A, Kollerits B, Freedman BI, Ponte B, Oostra BA, Paulweber B, Krämer BK, Mitchell BD, Buckley BM, Peralta CA, Hayward C, Helmer C, Rotimi CN, Shaffer CM, Müller C, Sala C, van Duijn CM, Saint-Pierre A, Ackermann D, Shriner D, Ruggiero D, Toniolo D, Lu Y, Cusi D, Czamara D, Ellinghaus D, Siscovick DS, Ruderfer D, Gieger C, Grallert H, Rochtchina E, Atkinson EJ, Holliday EG, Boerwinkle E, Salvi E, Bottinger EP, Murgia F, Rivadeneira F, Ernst F, Kronenberg F, Hu FB, Navis GJ, Curhan GC, Ehret GB, Homuth G, Coassin S, Thun GA, Pistis G, Gambaro G, Malerba G, Montgomery GW, Eiriksdottir G, Jacobs G, Li G, Wichmann HE, Campbell H, Schmidt H, Wallaschofski H, Völzke H, Brenner H, Kroemer HK, Kramer H, Lin H, Leach IM, Ford I, Guessous I, Rudan I, Prokopenko I, Borecki I, Heid IM, Kolcic I, Persico I, Jukema JW, Wilson JF, Felix JF, Divers J, Lambert JC, Stafford JM, Gaspoz JM, Smith JA, Faul JD, Wang JJ, Ding J, Hirschhorn JN, Attia J, Whitfield JB, Chalmers J, Viikari J, Coresh J, Denny JC, Karjalainen J, Fernandes JK, Endlich K, Butterbach K, Keene KL, Lohman K, Portas L, Launer LJ, Lyytikäinen LP, Yengo L, Franke L, Ferrucci L, Rose LM, Kedenko L, Rao M, Struchalin M, Kleber ME, Cavalieri M, Haun M, Cornelis MC, Ciullo M, Pirastu M, de Andrade M, McEvoy MA, Woodward M, Adam M, Cocca M, Nauck M, Imboden M, Waldenberger M, Pruijm M, Metzger M, Stumvoll M, Evans MK, Sale MM, Kähönen M, Boban M, Bochud M, Rheinberger M, Verweij N, Bouatia-Naji N, Martin NG, Hastie N, Probst-Hensch N, Soranzo N, Devuyst O, Raitakari O, Gottesman O, Franco OH, Polasek O, Gasparini P, Munroe PB, Ridker PM, Mitchell P, Muntner P, Meisinger C, Smit JH; ICBP Consortium.; AGEN Consortium.; CARDIOGRAM.; CHARGe-Heart Failure Group.; ECHOGen Consortium., Kovacs P, Wild PS, Froguel P, Rettig R, Mägi R, Biffar R, Schmidt R, Middelberg RP, Carroll RJ, Penninx BW, Scott RJ, Katz R, Sedaghat S, Wild SH, Kardia SL, Ulivi S, Hwang SJ, Enroth S, Kloiber S, Trompet S, Stengel B, Hancock SJ, Turner ST, Rosas SE, Stracke S, Harris TB, Zeller T, Zemunik T, Lehtimäki T, Illig T, Aspelund T, Nikopensius T, Esko T, Tanaka T, Gyllensten U, Völker U, Emilsson V, Vitart V, Aalto V, Gudnason V, Chouraki V, Chen WM, Igl W, März W, Koenig W, Lieb W, Loos RJ, Liu Y, Snieder H, Pramstaller PP, Parsa A, O'Connell JR, Susztak K, Hamet P, Tremblay J, de Boer IH, Böger CA, Goessling W, Chasman DI, Köttgen A, Kao WH, Fox CS. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016 Jan 21;7:10023. doi: 10.1038/ncomms10023. PubMed PMID: 26831199; PubMed Central PMCID: PMC4735748.
  11. Reiner AP, Susztak K. APOL1 Variants: From Parasites to Kidney Function to Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):219-20. doi: 10.1161/ATVBAHA.115.306794. PubMed PMID: 26819463; PubMed Central PMCID: PMC4732577.
  12. Kang HM, Huang S, Reidy K, Han SH, Chinga F, Susztak K. Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice. Cell Rep. 2016 Feb 2;14(4):861-71. doi: 10.1016/j.celrep.2015.12.071. PubMed PMID: 26776520; PubMed Central PMCID: PMC4854207.
  13. Huang S, Susztak K. Epithelial Plasticity versus EMT in Kidney Fibrosis. Trends Mol Med. 2016 Jan;22(1):4-6. doi: 10.1016/j.molmed.2015.11.009. PubMed PMID: 26700490; PubMed Central PMCID: PMC4854190.
  14. Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, Chu AY, Li M, Li Y, Mijatovic V, Ko YA, Taliun D, Luciani A, Chen MH, Yang Q, Foster MC, Olden M, Hiraki LT, Tayo BO, Fuchsberger C, Dieffenbach AK, Shuldiner AR, Smith AV, Zappa AM, Lupo A, Kollerits B, Ponte B, Stengel B, Krämer BK, Paulweber B, Mitchell BD, Hayward C, Helmer C, Meisinger C, Gieger C, Shaffer CM, Müller C, Langenberg C, Ackermann D, Siscovick D; DCCT/EDIC., Boerwinkle E, Kronenberg F, Ehret GB, Homuth G, Waeber G, Navis G, Gambaro G, Malerba G, Eiriksdottir G, Li G, Wichmann HE, Grallert H, Wallaschofski H, Völzke H, Brenner H, Kramer H, Mateo Leach I, Rudan I, Hillege HL, Beckmann JS, Lambert JC, Luan J, Zhao JH, Chalmers J, Coresh J, Denny JC, Butterbach K, Launer LJ, Ferrucci L, Kedenko L, Haun M, Metzger M, Woodward M, Hoffman MJ, Nauck M, Waldenberger M, Pruijm M, Bochud M, Rheinberger M, Verweij N, Wareham NJ, Endlich N, Soranzo N, Polasek O, van der Harst P, Pramstaller PP, Vollenweider P, Wild PS, Gansevoort RT, Rettig R, Biffar R, Carroll RJ, Katz R, Loos RJ, Hwang SJ, Coassin S, Bergmann S, Rosas SE, Stracke S, Harris TB, Corre T, Zeller T, Illig T, Aspelund T, Tanaka T, Lendeckel U, Völker U, Gudnason V, Chouraki V, Koenig W, Kutalik Z, O'Connell JR, Parsa A, Heid IM, Paterson AD, de Boer IH, Devuyst O, Lazar J, Endlich K, Susztak K, Tremblay J, Hamet P, Jacob HJ, Böger CA, Fox CS, Pattaro C, Köttgen A. Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes. Diabetes. 2016 Mar;65(3):803-17. doi: 10.2337/db15-1313. PubMed PMID: 26631737; PubMed Central PMCID: PMC4764151.
  15. Hakimi AA, Ostrovnaya I, Jacobsen A, Susztak K, Coleman JA, Russo P, Winer AG, Mano R, Sankin AI, Motzer RJ, Voss MH, Offit K, Purdue M, Pomerantz M, Freedman M, Choueiri TK, Hsieh JJ, Klein RJ. Validation and genomic interrogation of the MET variant rs11762213 as a predictor of adverse outcomes in clear cell renal cell carcinoma. Cancer. 2016 Feb 1;122(3):402-10. doi: 10.1002/cncr.29765. PubMed PMID: 26505625; PubMed Central PMCID: PMC4803437.
  16. Han SH, Malaga-Dieguez L, Chinga F, Kang HM, Tao J, Reidy K, Susztak K. Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism. J Am Soc Nephrol. 2016 Feb;27(2):439-53. doi: 10.1681/ASN.2014121181. PubMed PMID: 26054542; PubMed Central PMCID: PMC4731117.

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2015

  1. Kang HM, Huang S, Reidy K, Han SH, Chinga F, Susztak K. Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice. Cell Rep. 2016 Feb 2;14(4):861-71. doi: 10.1016/j.celrep.2015.12.071. PubMed PMID: 26776520; PubMed Central PMCID: PMC4854207.
  2. Huang S, Susztak K. Epithelial Plasticity versus EMT in Kidney Fibrosis. Trends Mol Med. 2016 Jan;22(1):4-6. doi: 10.1016/j.molmed.2015.11.009. PubMed PMID: 26700490; PubMed Central PMCID: PMC4854190.
  3. Lin J, Zhang X, Xue C, Zhang H, Shashaty MG, Gosai SJ, Meyer N, Grazioli A, Hinkle C, Caughey J, Li W, Susztak K, Gregory BD, Li M, Reilly MP. The long noncoding RNA landscape in hypoxic and inflammatory renal epithelial injury. Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F901-13. doi: 10.1152/ajprenal.00290.2015. PubMed PMID: 26400545; PubMed Central PMCID: PMC4669357.
  4. Sweetwyne MT, Gruenwald A, Niranjan T, Nishinakamura R, Strobl LJ, Susztak K. Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development. Diabetes. 2015 Dec;64(12):4099-111. doi: 10.2337/db15-0260. PubMed PMID: 26293507; PubMed Central PMCID: PMC4657584.
  5. Shenoy N, Vallumsetla N, Zou Y, Galeas JN, Shrivastava M, Hu C, Susztak K, Verma A. Role of DNA methylation in renal cell carcinoma. J Hematol Oncol. 2015 Jul 22;8:88. doi: 10.1186/s13045-015-0180-y. Review. PubMed PMID: 26198328; PubMed Central PMCID: PMC4511443.
  6. Na J, Sweetwyne MT, Park AS, Susztak K, Cagan RL. Diet-Induced Podocyte Dysfunction in Drosophila and Mammals. Cell Rep. 2015 Jul 28;12(4):636-47. doi: 10.1016/j.celrep.2015.06.056. PubMed PMID: 26190114; PubMed Central PMCID: PMC4532696.
  7. Stadler K, Goldberg IJ, Susztak K. The evolving understanding of the contribution of lipid metabolism to diabetic kidney disease. Curr Diab Rep. 2015 Jul;15(7):40. doi: 10.1007/s11892-015-0611-8. Review. PubMed PMID: 25957525; PubMed Central PMCID: PMC4548922.
  8. Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S, Rossing P, Groop PH, Cooper ME. Diabetic kidney disease. Nat Rev Dis Primers. 2015 Jul 30;1:15018. doi: 10.1038/nrdp.2015.18. PubMed PMID: 27188921.
  9. Germain M, Pezzolesi MG, Sandholm N, McKnight AJ, Susztak K, Lajer M, Forsblom C, Marre M, Parving HH, Rossing P, Toppila I, Skupien J, Roussel R, Ko YA, Ledo N, Folkersen L, Civelek M, Maxwell AP, Tregouet DA, Groop PH, Tarnow L, Hadjadj S. SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes. Diabetologia. 2015 Mar;58(3):543-8. doi: 10.1007/s00125-014-3459-6. PubMed PMID: 25476525.
  10. Kang HM, Ahn SH, Choi P, Ko YA, Han SH, Chinga F, Park AS, Tao J, Sharma K, Pullman J, Bottinger EP, Goldberg IJ, Susztak K. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. Nat Med. 2015 Jan;21(1):37-46. doi: 10.1038/nm.3762. PubMed PMID: 25419705; PubMed Central PMCID: PMC4444078.
  11. Ledo N, Ko YA, Park AS, Kang HM, Han SY, Choi P, Susztak K. Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD. J Am Soc Nephrol. 2015 Mar;26(3):692-714. doi: 10.1681/ASN.2014010028. PubMed PMID: 25231882; PubMed Central PMCID: PMC4341476.
     

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2014

  1. Sweetwyne MT, Tao J, Susztak K. Kick it up a notch: Notch signaling and kidney fibrosis. Kidney Int Suppl (2011). 2014 Nov;4(1):91-96. Review. PubMed PMID: 26312157; PubMed Central PMCID: PMC4536967.
  2. Han SH, Malaga-Dieguez L, Chinga F, Kang HM, Tao J, Reidy K, Susztak K. Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism. J Am Soc Nephrol. 2016 Feb;27(2):439-53. doi: 10.1681/ASN.2014121181. PubMed PMID: 26054542; PubMed Central PMCID: PMC4731117.
  3. Susztak K, Cifra A. 'Back and forth' from models to patients to understand kidney disease: an interview with Katalin Susztak. Dis Model Mech. 2014 Dec;7(12):1317-9. doi: 10.1242/dmm.018911. PubMed PMID: 25481011; PubMed Central PMCID: PMC4257000.
  4. Ledo N, Ko YA, Park AS, Kang HM, Han SY, Choi P, Susztak K. Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD. J Am Soc Nephrol. 2015 Mar;26(3):692-714. doi: 10.1681/ASN.2014010028. PubMed PMID: 25231882; PubMed Central PMCID: PMC4341476.
  5. Scharpf RB, Mireles L, Yang Q, Köttgen A, Ruczinski I, Susztak K, Halper-Stromberg E, Tin A, Cristiano S, Chakravarti A, Boerwinkle E, Fox CS, Coresh J, Linda Kao WH. Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations. BMC Genet. 2014 Jul 9;15:81. doi: 10.1186/1471-2156-15-81. PubMed PMID: 25007794; PubMed Central PMCID: PMC4118309.
  6. Hu CY, Mohtat D, Yu Y, Ko YA, Shenoy N, Bhattacharya S, Izquierdo MC, Park AS, Giricz O, Vallumsetla N, Gundabolu K, Ware K, Bhagat TD, Suzuki M, Pullman J, Liu XS, Greally JM, Susztak K, Verma A. Kidney cancer is characterized by aberrant methylation of tissue-specific enhancers that are prognostic for overall survival. Clin Cancer Res. 2014 Aug 15;20(16):4349-60. doi: 10.1158/1078-0432.CCR-14-0494. PubMed PMID: 24916699; PubMed Central PMCID: PMC4424050.
  7. Reidy K, Kang HM, Hostetter T, Susztak K. Molecular mechanisms of diabetic kidney disease. J Clin Invest. 2014 Jun;124(6):2333-40. doi: 10.1172/JCI72271. Review. PubMed PMID: 24892707; PubMed Central PMCID: PMC4089448.
  8. Beckerman P, Susztak K. Sweet debate: fructose versus glucose in diabetic kidney disease. J Am Soc Nephrol. 2014 Nov;25(11):2386-8. doi: 10.1681/ASN.2014050433. PubMed PMID: 24876119; PubMed Central PMCID: PMC4214542.
  9. Beckerman P, Ko YA, Susztak K. Epigenetics: a new way to look at kidney diseases. Nephrol Dial Transplant. 2014 Oct;29(10):1821-7. doi: 10.1093/ndt/gfu026. Review. PubMed PMID: 24675284; PubMed Central PMCID: PMC4173816.
  10. Wing MR, Devaney JM, Joffe MM, Xie D, Feldman HI, Dominic EA, Guzman NJ, Ramezani A, Susztak K, Herman JG, Cope L, Harmon B, Kwabi-Addo B, Gordish-Dressman H, Go AS, He J, Lash JP, Kusek JW, Raj DS; Chronic Renal Insufficiency Cohort (CRIC) Study.. DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant. 2014 Apr;29(4):864-72. doi: 10.1093/ndt/gft537. PubMed PMID: 24516231; PubMed Central PMCID: PMC3967834.
  11. Dember LM, Susztak K. Notch ties a knot on fistula maturation. J Am Soc Nephrol. 2014 Apr;25(4):648-50. doi: 10.1681/ASN.2014010005. PubMed PMID: 24480826; PubMed Central PMCID: PMC3968513.
  12. Han SH, Susztak K. The hyperglycemic and hyperinsulinemic combo gives you diabetic kidney disease immediately. Focus on "Combined acute hyperglycemic and hyperinsulinemic clamp induced profibrotic and proinflammatory responses in the kidney". Am J Physiol Cell Physiol. 2014 Feb 1;306(3):C198-9. doi: 10.1152/ajpcell.00371.2013. PubMed PMID: 24336650; PubMed Central PMCID: PMC3919999.
  13. Tao J, Polumbo C, Reidy K, Sweetwyne M, Susztak K. A multicolor podocyte reporter highlights heterogeneous podocyte changes in focal segmental glomerulosclerosis. Kidney Int. 2014 Apr;85(4):972-80. doi: 10.1038/ki.2013.463. PubMed PMID: 24284512; PubMed Central PMCID: PMC3987991.
  14. Susztak K. Understanding the epigenetic syntax for the genetic alphabet in the kidney. J Am Soc Nephrol. 2014 Jan;25(1):10-7. doi: 10.1681/ASN.2013050461. Review. PubMed PMID: 24179169; PubMed Central PMCID: PMC3871782.
     

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Previously

  1. Hackl MJ, Burford JL, Villanueva K, Lam L, Suszták K, Schermer B, Benzing T, Peti-Peterdi J. Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. Nat Med. 2013 Dec;19(12):1661-6. doi: 10.1038/nm.3405. PubMed PMID: 24270544; PubMed Central PMCID: PMC3884556.
  2. Malaga-Dieguez L, Susztak K. ADCK4 "reenergizes" nephrotic syndrome. J Clin Invest. 2013 Dec;123(12):4996-9. doi: 10.1172/JCI73168. PubMed PMID: 24270414; PubMed Central PMCID: PMC3859427.
  3. Nihalani D, Susztak K. Sirt1-Claudin-1 crosstalk regulates renal function. Nat Med. 2013 Nov;19(11):1371-2. doi: 10.1038/nm.3386. PubMed PMID: 24202384.
  4. Ko YA, Mohtat D, Suzuki M, Park AS, Izquierdo MC, Han SY, Kang HM, Si H, Hostetter T, Pullman JM, Fazzari M, Verma A, Zheng D, Greally JM, Susztak K. Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development. Genome Biol. 2013;14(10):R108. PubMed PMID: 24098934; PubMed Central PMCID: PMC4053753.
  5. Ko YA, Susztak K. Epigenomics: the science of no-longer-junk DNA. Why study it in chronic kidney disease? Semin Nephrol. 2013 Jul;33(4):354-62. doi: 10.1016/j.semnephrol.2013.05.007. Review. PubMed PMID: 24011577; PubMed Central PMCID: PMC3815533.
  6. Breyer MD, Coffman TM, Flessner MF, Fried LF, Harris RC, Ketchum CJ, Kretzler M, Nelson RG, Sedor JR, Susztak K; Kidney Research National Dialogue (KRND).. Diabetic nephropathy: a national dialogue. Clin J Am Soc Nephrol. 2013 Sep;8(9):1603-5. doi: 10.2215/CJN.03640413. PubMed PMID: 23788618; PubMed Central PMCID: PMC3805071.
  7. Sweetwyne MT, Susztak K. For better or worse: a niche for Notch in parietal epithelial cell activation. Kidney Int. 2013 Jun;83(6):988-90. doi: 10.1038/ki.2013.66. PubMed PMID: 23728000; PubMed Central PMCID: PMC3671494.
  8. Wang Y, Wu B, Chamberlain AA, Lui W, Koirala P, Susztak K, Klein D, Taylor V, Zhou B. Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS One. 2013;8(4):e60244. doi: 10.1371/journal.pone.0060244. PubMed PMID: 23560082; PubMed Central PMCID: PMC3613384.
  9. Rutkowski JM, Wang ZV, Park AS, Zhang J, Zhang D, Hu MC, Moe OW, Susztak K, Scherer PE. Adiponectin promotes functional recovery after podocyte ablation. J Am Soc Nephrol. 2013 Feb;24(2):268-82. doi: 10.1681/ASN.2012040414. PubMed PMID: 23334396; PubMed Central PMCID: PMC3559480.
  10. Kato H, Susztak K. Repair problems in podocytes: Wnt, Notch, and glomerulosclerosis. Semin Nephrol. 2012 Jul;32(4):350-6. doi: 10.1016/j.semnephrol.2012.06.006. Review. PubMed PMID: 22958489; PubMed Central PMCID: PMC3466477.
  11. Huber TB, Edelstein CL, Hartleben B, Inoki K, Jiang M, Koya D, Kume S, Lieberthal W, Pallet N, Quiroga A, Ravichandran K, Susztak K, Yoshida S, Dong Z. Emerging role of autophagy in kidney function, diseases and aging. Autophagy. 2012 Jul 1;8(7):1009-31. doi: 10.4161/auto.19821. Review. PubMed PMID: 22692002; PubMed Central PMCID: PMC3429540.
  12. Bonegio R, Susztak K. Notch signaling in diabetic nephropathy. Exp Cell Res. 2012 May 15;318(9):986-92. doi: 10.1016/j.yexcr.2012.02.036. Review. PubMed PMID: 22414874; PubMed Central PMCID: PMC3677813.
  13. Sirin Y, Susztak K. Notch in the kidney: development and disease. J Pathol. 2012 Jan;226(2):394-403. doi: 10.1002/path.2967. Review. PubMed PMID: 21952830; PubMed Central PMCID: PMC3677191.
  14. Woroniecka KI, Park AS, Mohtat D, Thomas DB, Pullman JM, Susztak K. Transcriptome analysis of human diabetic kidney disease. Diabetes. 2011 Sep;60(9):2354-69. doi: 10.2337/db10-1181. PubMed PMID: 21752957; PubMed Central PMCID: PMC3161334.
  15. Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM, Faul C, Millar SE, Holzman LB, Susztak K. Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem. 2011 Jul 22;286(29):26003-15. doi: 10.1074/jbc.M111.223164. PubMed PMID: 21613219; PubMed Central PMCID: PMC3138306.
  16. Chang GY, Park AS, Susztak K. Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease. Kidney Int. 2011 Apr;79(8):802-4. doi: 10.1038/ki.2010.559. PubMed PMID: 21451535; PubMed Central PMCID: PMC3677185.
  17. Woroniecki R, Gaikwad AB, Susztak K. Fetal environment, epigenetics, and pediatric renal disease. Pediatr Nephrol. 2011 May;26(5):705-11. doi: 10.1007/s00467-010-1714-8. Review. PubMed PMID: 21174217; PubMed Central PMCID: PMC3063864.
  18. Sharma S, Sirin Y, Susztak K. The story of Notch and chronic kidney disease. Curr Opin Nephrol Hypertens. 2011 Jan;20(1):56-61. doi: 10.1097/MNH.0b013e3283414c88. Review. PubMed PMID: 21088575; PubMed Central PMCID: PMC3164509.
  19. Mohtat D, Susztak K. Fine tuning gene expression: the epigenome. Semin Nephrol. 2010 Sep;30(5):468-76. doi: 10.1016/j.semnephrol.2010.07.004. Review. Erratum in: Semin Nephrol. 2011 Jan;31(1):123. PubMed PMID: 21044758; PubMed Central PMCID: PMC3164355.
  20. Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest. 2010 Nov;120(11):4040-54. doi: 10.1172/JCI43025. PubMed PMID: 20978353; PubMed Central PMCID: PMC2964979.
  21. Ahn SH, Susztak K. Getting a notch closer to understanding diabetic kidney disease. Diabetes. 2010 Aug;59(8):1865-7. doi: 10.2337/db10-0077. PubMed PMID: 20668292; PubMed Central PMCID: PMC2911058.
  22. Murea M, Park JK, Sharma S, Kato H, Gruenwald A, Niranjan T, Si H, Thomas DB, Pullman JM, Melamed ML, Susztak K. Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function. Kidney Int. 2010 Sep;78(5):514-22. doi: 10.1038/ki.2010.172. PubMed PMID: 20531454; PubMed Central PMCID: PMC3164583.
  23. Chua S Jr, Li Y, Liu SM, Liu R, Chan KT, Martino J, Zheng Z, Susztak K, D'Agati VD, Gharavi AG. A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8. Kidney Int. 2010 Sep;78(5):453-62. doi: 10.1038/ki.2010.160. PubMed PMID: 20520596; PubMed Central PMCID: PMC3998677.
  24. Reidy K, Susztak K. Epithelial-mesenchymal transition and podocyte loss in diabetic kidney disease. Am J Kidney Dis. 2009 Oct;54(4):590-3. doi: 10.1053/j.ajkd.2009.07.003. PubMed PMID: 19781451; PubMed Central PMCID: PMC2761212.
  25. Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T; Animal Models of Diabetic Complications Consortium.. Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2009 Dec;20(12):2503-12. doi: 10.1681/ASN.2009070721. Review. PubMed PMID: 19729434; PubMed Central PMCID: PMC4075053.
  26. Niranjan T, Murea M, Susztak K. The pathogenic role of Notch activation in podocytes. Nephron Exp Nephrol. 2009;111(4):e73-9. doi: 10.1159/000209207. Review. PubMed PMID: 19293596; PubMed Central PMCID: PMC2851161.
  27. Si H, Banga RS, Kapitsinou P, Ramaiah M, Lawrence J, Kambhampati G, Gruenwald A, Bottinger E, Glicklich D, Tellis V, Greenstein S, Thomas DB, Pullman J, Fazzari M, Susztak K. Human and murine kidneys show gender- and species-specific gene expression differences in response to injury. PLoS One. 2009;4(3):e4802. doi: 10.1371/journal.pone.0004802. PubMed PMID: 19277126; PubMed Central PMCID: PMC2652077.
  28. Kato H, Si H, Hostetter T, Susztak K. Smad1 as a biomarker for diabetic nephropathy. Diabetes. 2008 Jun;57(6):1459-60. doi: 10.2337/db08-0365. PubMed PMID: 18511448.
  29. Lorenzen J, Shah R, Biser A, Staicu SA, Niranjan T, Garcia AM, Gruenwald A, Thomas DB, Shatat IF, Supe K, Woroniecki RP, Susztak K. The role of osteopontin in the development of albuminuria. J Am Soc Nephrol. 2008 May;19(5):884-90. doi: 10.1681/ASN.2007040486. PubMed PMID: 18443355; PubMed Central PMCID: PMC2386721.
  30. Niranjan T, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med. 2008 Mar;14(3):290-8. doi: 10.1038/nm1731. PubMed PMID: 18311147.
  31. Susztak K, Bitzer M, Meyer TW, Hostetter TH. Animal models of renal disease. Kidney Int. 2008 Mar;73(5):526-8. doi: 10.1038/sj.ki.5002724. PubMed PMID: 18274542.
  32. Szabó C, Biser A, Benko R, Böttinger E, Suszták K. Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov;55(11):3004-12. PubMed PMID: 17065336.
  33. Susztak K, Böttinger EP. Diabetic nephropathy: a frontier for personalized medicine. J Am Soc Nephrol. 2006 Feb;17(2):361-7. Review. PubMed PMID: 16407421.
  34. Susztak K, Raff AC, Schiffer M, Böttinger EP. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes. 2006 Jan;55(1):225-33. PubMed PMID: 16380497.
  35. Schiffer M, Susztak K, Ranalletta M, Raff AC, Böttinger EP, Charron MJ. Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions. Am J Physiol Renal Physiol. 2005 Jul;289(1):F186-93. PubMed PMID: 15741607.
  36. Susztak K, Ciccone E, McCue P, Sharma K, Böttinger EP. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. PLoS Med. 2005 Feb;2(2):e45. PubMed PMID: 15737001; PubMed Central PMCID: PMC549593.
  37. Susztak K, Böttinger E, Novetsky A, Liang D, Zhu Y, Ciccone E, Wu D, Dunn S, McCue P, Sharma K. Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Diabetes. 2004 Mar;53(3):784-94. PubMed PMID: 14988265.
  38. Susztak K, Sharma K, Schiffer M, McCue P, Ciccone E, Böttinger EP. Genomic strategies for diabetic nephropathy. J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S271-8. Review. PubMed PMID: 12874445.
  39. von Gersdorff G, Susztak K, Rezvani F, Bitzer M, Liang D, Böttinger EP. Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta. J Biol Chem. 2000 Apr 14;275(15):11320-6. PubMed PMID: 10753944.
  40. Schiffer M, von Gersdorff G, Bitzer M, Susztak K, Böttinger EP. Smad proteins and transforming growth factor-beta signaling. Kidney Int Suppl. 2000 Sep;77:S45-52. Review. PubMed PMID: 10997690.
  41. Suszták K, Mócsai A, Ligeti E, Kapus A. Electrogenic H+ pathway contributes to stimulus-induced changes of internal pH and membrane potential in intact neutrophils: role of cytoplasmic phospholipase A2. Biochem J. 1997 Jul 15;325 ( Pt 2):501-10. PubMed PMID: 9230134; PubMed Central PMCID: PMC1218588.
  42. Káldi K, Szászi K, Koncz G, Suszták K, Ligeti E. Arachidonic acid activatable electrogenic H+ transport in the absence of cytochrome b558 in human T lymphocytes. FEBS Lett. 1996 Feb 26;381(1-2):156-60. PubMed PMID: 8641428.
  43. Suszták K, Káldi K, Kapus A, Ligeti E. Ligands of purinergic receptors stimulate electrogenic H(+)-transport of neutrophils. FEBS Lett. 1995 Nov 13;375(1-2):79-82. PubMed PMID: 7498486.
  44. Káldi K, Szászi K, Suszták K, Kapus A, Ligeti E. Lymphocytes possess an electrogenic H(+)-transporting pathway in their plasma membrane. Biochem J. 1994 Jul 15;301 ( Pt 2):329-34. PubMed PMID: 7519007; PubMed Central PMCID: PMC1137083.
  45. Kapus A, Suszták K, Ligeti E. Regulation of the electrogenic H+ channel in the plasma membrane of neutrophils: possible role of phospholipase A2, internal and external protons. Biochem J. 1993 Jun 1;292 ( Pt 2):445-50. PubMed PMID: 7684901; PubMed Central PMCID: PMC1134229.
     

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Selected Publications:

  1. Jihwan Park, Rojesh Shrestha, Chengxiang Qiu, Ayano Kondo, Shizheng Huang, Max Werth, Mingyao Li, Jonathan Barasch, Katalin Suszták. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science  05 Apr 2018: eaar2131. DOI: 10.1126/science.aar2131

  2. Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K. Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nat Med. 2017 Apr;23(4):429-438. doi: 10.1038/nm.4287. Epub 2017 Feb 20. PubMed PMID: 28218918.

  3. Kang HM, Ahn SH, Choi P, Ko YA, Han SH, Chinga F, Park AS, Tao J, Sharma K, Pullman J, Bottinger EP, Goldberg IJ, Susztak K. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. Nat Med. 2015 Jan;21(1):37-46. doi: 10.1038/nm.3762. PubMed PMID: 25419705; PubMed Central PMCID: PMC4444078.

  4. Niranjan T, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med. 2008 Mar;14(3):290-8. Epub 2008 Mar 2. PMID: 18311147.