Perelman School of Medicine at the University of Pennsylvania

Topics in Molecular Medicine

Syllabus | Fall 2022

CAMB 542-401 | Topics in Molecular Medicine  

  Date Class Time Faculty Preceptor Topic Assigned Reading/s
1
Monday, August 29 2:30-4:00PM

Elizabeth J. K. Bhoj, MD, PhD

Diagnosis, Mechanism, and Targeted Treatment of Rare Disorders

Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome

Supplement: 
How many rare diseases are there?

2
Friday, September 9 2:30-4:00PM Mark Kahn, MD How tumor cells use lymphatic vessels and lymph nodes to reach the blood: New concepts in metastasis

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice

Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice

Supplement:
Molecular Basis of Metastasis

3
Friday, September 23 2:30-4:00PM Mark Sellmyer, MD, PhD Translational chemical biology: control of protein levels in vivo

Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

Supplement: 
Chimeric antigen receptor T‐cell therapy — assessment and management of toxicities

4
Friday, September 30 2:00-3:00PM Rajan Jain, MD
Rahul Kohli, MD, PhD
Mentors and Mentees  
5
Monday, October 3 2:30-4:00PM Matthew Kayser, MD, PhD Making connections between sleep and loneliness 

Chronic social isolation signals starvation and reduces sleep in Drosophila

Supplements: 
Sleep, insomnia, and depression

The growing problem of loneliness

6
Monday, October 17 2:30-4:00PM Joshua Franklin, MD, PhD Ethnographic and cross-cultural approaches to psychosis and other unshared experiences

Beyond Trauma: A Multiple Pathways Approach to Auditory Hallucinations in Clinical and Nonclinical Populations

Supplement:
"Introduction" from Our Most Troubling Madness : Case Studies in Schizophrenia Across Cultures

7
Friday, October 21 2:30-4:00PM Richard Phillips, MD, PhD Epigenetic mechanisms driving malignant transformation of neural cells

Insulator dysfunction and oncogene activation in IDH mutant gliomas

Supplement:
Glioma

8
Monday, October 24 2:30-4:00PM Vikram Paralkar, MD Targeting the Leukemia Epigenome

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo
 

Supplements:
Therapeutic implications of menin inhibition in acute leukemias

The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

9
Monday, October 31 2:30-4:00PM Marco Ruella, MD Targeting cytokine release syndrome associated with CAR-T therapy

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
Data: Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

Supplements: 
Time to evolve: predicting engineered T cell-associated toxicity with next-generation models
Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

10
Friday, November 18 2:30-4:00PM

Katharine Bar, MD

Engineering B cells to Neutralize HIV

In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice

11
Monday, November 21 2:30-4:00PM Jonathan Miner, MD, PhD

Single gene mutations associated with severe COVID19

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Supplement:
Severe Covid-19

12
Monday, November 28 2:30-4:00PM Sharlene Day, MD Clonal hematopoiesis of indeterminate potential (CHIP) in atherosclerotic heart disease

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

Supplement:
Inflammation during the life cycle of the atherosclerotic plaque