Perelman School of Medicine at the University of Pennsylvania

Topics in Molecular Medicine

Syllabus | Fall 2023

CAMB 542-401 | Topics in Molecular Medicine  

  Date Class Time Faculty Preceptor Topic Assigned Reading/s
1

Friday, September 8

3:30 PM - 5:00 PM

Ben Z. Stanger, MD, PhD Targeting mutant KRAS in cancer: A 40-year overnight sensation

Scientific Paper:
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Clinical Research Paper:
Setting the Benchmark for KRASG12C-Mutated NSCLC

Supplemental Reference Paper:
Targeting KRAS mutant lung cancer: light at the end of the tunnel

  Monday, September 18 3:00 PM - 4:15 PM Michael S. Brown, MD Meyerhof-Matschinsky Lecture

None

Location: Rubenstein Auditorium, Smilow

2

Friday, September 22

3:30 PM - 5:00 PM

Mark Sellmyer, MD, PhD In vivo biorthogonal chemistry for imaging

Scientific Research Paper:
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry

Clinical Research Paper:
131 I-Tositumomab Therapy as Initial Treatment for Follicular Lymphoma

3

Monday, September 25

3:30 PM - 5:00 PM

Rajan Jain, MD
Rahul Kohli, MD, PhD
Mentor and Mentee Relationships None
4

Monday, October 2

3:30 PM - 5:00 PM

Iahn Cajigas Gonzalez, MD, PhD

Functional Motor Neurorestoration with Brain Computer Interfaces

Scientific Paper:
Walking naturally after spinal cord injury using a brain–spine interface

Clinical Research Paper:
Brain-computer interfaces for communication

5

Friday, October 6

3:30 PM - 5:00 PM

Sydney M. Shaffer, MD, PhD Understanding Early Tumor Evolution for Better Clinical Outcomes

Scientific Paper:
A Big Bang model of human colorectal tumor growth

Clinical Research Paper:
Tracking the Evolution of Non–Small-Cell Lung Cancer

Supplemental Reference Paper:
Harnessing Tumor Evolution to Circumvent Resistance

6

Monday, October 16

3:30 PM - 5:00 PM

Michael J. Gandal, MD, PhD

The Complement Signaling Pathway in Schizophrenia

Scientific Paper:
Schizophrenia risk from complex variation of complement component 4

Clinical Research Paper:
Schizophrenia

7

Monday, October 23

3:30 PM - 5:00 PM

Kevin B. Johnson, MD, MS Making Artificial Intelligence Actionable in Medicine Scientific Paper:
Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis
8

Monday, October 30

3:30 PM - 5:00 PM

Marie A Guerraty, MD, PhD

The coronary microvasculature in Takatsubo cardiomyopathy

Scientific Paper: 
Takotsubo syndrome is a coronary microvascular disease: experimental evidence

Clinical Research Paper:
Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications

9

Friday, November 3

3:30 PM - 5:00 PM

Maria Basil, MD, PhD

A breath of fresh air: How observations at the bedside can inform new biology at the bench

Scientific Paper:
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance

Clinical Research Paper: 
Bronchiectasis — A Clinical Review

10

Monday, November 13

3:30 PM - 5:00 PM

Christoph Ellebrecht, MD

Blistering Challenges: Understanding Bullous Pemphigoid in the Context of Anti-PD1 Therapy

Scientific Paper:
Identification of essential genes for cancer immunotherapy

Clinical Research Paper:
Association of Bullous Pemphigoid With Immune Checkpoint Inhibitor Therapy in Patients With Cancer: A Systematic Review

11

Monday, November 20

3:30 PM - 5:00 PM

Sarah Henrickson, MD, PhD

Precision medicine in rare immune regulatory disorders

Scientific Paper:
Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

Clinical Research Paper:
Genetics of Pediatric Immune-Mediated Diseases and Human Immunity

Supplemental Reference Paper:
Human inborn errors of immunity: An expanding universe

12

Monday, November 27

3:30 PM - 5:00 PM

Audrey Odom John, MD, PhD

“Life finds a way [Ian Malcolm, Jurassic Park]”: Are malaria parasites evolving to avoid diagnostic tests?

Scientific Paper:
Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia

Clinical Research Paper:
HRP2: Transforming Malaria Diagnosis, but with Caveats