Topics in Molecular Medicine

Syllabus

Syllabus | Fall 2023

CAMB 542-401 | Topics in Molecular Medicine

	Date	Class Time	Faculty Preceptor	Topic	Assigned Reading/s
1	Friday, September 8	3:30 PM - 5:00 PM	Ben Z. Stanger, MD, PhD	Targeting mutant KRAS in cancer: A 40-year overnight sensation	Scientific Paper: Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor Clinical Research Paper: Setting the Benchmark for KRAS^G12C-Mutated NSCLC Supplemental Reference Paper: Targeting KRAS mutant lung cancer: light at the end of the tunnel
	Monday, September 18	3:00 PM - 4:15 PM	Michael S. Brown, MD	Meyerhof-Matschinsky Lecture	None Location: Rubenstein Auditorium, Smilow
2	Friday, September 22	3:30 PM - 5:00 PM	Mark Sellmyer, MD, PhD	In vivo biorthogonal chemistry for imaging	Scientific Research Paper: A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry Clinical Research Paper: 131 I-Tositumomab Therapy as Initial Treatment for Follicular Lymphoma
3	Monday, September 25	3:30 PM - 5:00 PM	Rajan Jain, MD Rahul Kohli, MD, PhD	Mentor and Mentee Relationships	None
4	Monday, October 2	3:30 PM - 5:00 PM	Iahn Cajigas Gonzalez, MD, PhD	Functional Motor Neurorestoration with Brain Computer Interfaces	Scientific Paper: Walking naturally after spinal cord injury using a brain–spine interface Clinical Research Paper: Brain-computer interfaces for communication
5	Friday, October 6	3:30 PM - 5:00 PM	Sydney M. Shaffer, MD, PhD	Understanding Early Tumor Evolution for Better Clinical Outcomes	Scientific Paper: A Big Bang model of human colorectal tumor growth Clinical Research Paper: Tracking the Evolution of Non–Small-Cell Lung Cancer Supplemental Reference Paper: Harnessing Tumor Evolution to Circumvent Resistance
6	Monday, October 16	3:30 PM - 5:00 PM	Michael J. Gandal, MD, PhD	The Complement Signaling Pathway in Schizophrenia	Scientific Paper: Schizophrenia risk from complex variation of complement component 4 Clinical Research Paper: Schizophrenia
7	Monday, October 23	3:30 PM - 5:00 PM	Kevin B. Johnson, MD, MS	Making Artificial Intelligence Actionable in Medicine	Scientific Paper: Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis
8	Monday, October 30	3:30 PM - 5:00 PM	Marie A Guerraty, MD, PhD	The coronary microvasculature in Takatsubo cardiomyopathy	Scientific Paper: Takotsubo syndrome is a coronary microvascular disease: experimental evidence Clinical Research Paper: Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications
9	Friday, November 3	3:30 PM - 5:00 PM	Maria Basil, MD, PhD	A breath of fresh air: How observations at the bedside can inform new biology at the bench	Scientific Paper: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance Clinical Research Paper: Bronchiectasis — A Clinical Review
10	Monday, November 13	3:30 PM - 5:00 PM	Christoph Ellebrecht, MD	Blistering Challenges: Understanding Bullous Pemphigoid in the Context of Anti-PD1 Therapy	Scientific Paper: Identification of essential genes for cancer immunotherapy Clinical Research Paper: Association of Bullous Pemphigoid With Immune Checkpoint Inhibitor Therapy in Patients With Cancer: A Systematic Review
11	Monday, November 20	3:30 PM - 5:00 PM	Sarah Henrickson, MD, PhD	Precision medicine in rare immune regulatory disorders	Scientific Paper: Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy Clinical Research Paper: Genetics of Pediatric Immune-Mediated Diseases and Human Immunity Supplemental Reference Paper: Human inborn errors of immunity: An expanding universe
12	Monday, November 27	3:30 PM - 5:00 PM	Audrey Odom John, MD, PhD	“Life finds a way [Ian Malcolm, Jurassic Park]”: Are malaria parasites evolving to avoid diagnostic tests?	Scientific Paper: Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia Clinical Research Paper: HRP2: Transforming Malaria Diagnosis, but with Caveats

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