Syllabus | Fall 2024
CAMB 542-401 | Topics in Molecular Medicine
| Date | Class Time | Faculty Preceptor | Topic | Assigned Reading | |
|---|---|---|---|---|---|
1 |
Friday, September 6 | 3:30-5:00PM | Katharine J Bar, MD | Deep characterization of the HIV reservoir |
Research Paper: Phenotypic signatures of immune selection in HIV-1 reservoir cells Clinical Review: Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021 |
2 |
Monday, September 9 | 3:30-5:00PM | Sydney Shaffer, MD, PhD | Implications of tumor evolution for cancer treatment |
Research Paper: A Big Bang model of human colorectal tumor growth Clinical Review: Tracking the Evolution of Non–Small-Cell Lung Cancer Supplemental Reference: Harnessing Tumor Evolution to Circumvent Resistance |
3 |
Friday, September 13 | 3:30-5:00PM | Xilma Ortiz-Gonzalez, MD, PhD | Emerging mechanisms of neurodegeneration across the age spectrum |
Clinical Review: Causes of death among United States decedents with ALS: An eye toward delaying mortality |
4 |
Wednesday, September 25 | 3:30-5:00PM | Jonathan Miner, MD, PhD | STING-associated autoinflammation |
Research Paper: Human STING is a proton channel Clinical Reviews: Activated STING in a vascular and pulmonary syndrome A path towards personalized medicines for autoinflammatory and related diseases |
5 |
Monday, September 30 | 3:30-5:00PM | Nicole Maloney, MD, PhD | Exploring Tissue regeneration in the Gut |
Research Paper: TGFB1 induces fetal reprogramming and enhances intestinal regeneration Clinical Review: Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression? |
6 |
Monday, October 7 | 3:30-5:00PM | Rajan Jain, MD Rahul Kohli, MD, PhD |
Mentor and Mentee Relationships | None |
7 |
Friday, October 11 | 3:30-5:00PM | David Frank, MD, PhD | Chimeric receptor ligand traps to treat pulmonary arterial hypertension |
Research Paper: ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension Clinical Reviews: Pulmonary hypertension Sotatercept for the Treatment of PulmonaryArterial Hypertension A Selective Transforming Growth Factor-b Ligand Trap Attenuates Pulmonary Hypertension |
8 |
Monday, October 21 | 3:30-5:00PM | Theodore Drivas, MD, PhD | Ciliary signaling in rare and common disease |
Research Paper: Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia Clinical Review: Bardet-Biedl syndrome: A clinical overview focusing on diagnosis, outcomes and best-practice management |
9 |
Monday, October 28 | 3:30-5:00PM | Matthew Kayser, MD, PhD | Why does insufficient sleep make us sick? |
Research Paper: Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut Clinical Review: The Global Problem of Insufficient Sleep and Its Serious Public Health Implications |
10 |
Friday, November 1 | 3:30-5:00PM | Mark Sellmyer, MD, PhD | Getting synthetic biology to the clinic |
Research Paper: Modular design of synthetic receptors for programmed gene regulation in cell therapies Clinical Review: Synthetic Biology in the Engineering of CAR-T and CAR-NK Cell Therapies: Facts and Hopes |
11 |
Friday, November 8 | 3:30-5:00PM | Daria Babushok, MD, PhD | Disease pathogenesis and targeted therapeutics for telomere biology disorders |
Research Paper: Thymidine nucleotide metabolism controls human telomere length Clinical Review: Clinical manifestations of telomere biology disorders in adults |
12 |
Monday, November 18 | 3:30-5:00PM | Iahn Cajigas Gonzalez, MD, PhD | Neuromodulation and Brain Computer Interfaces as a Treatment Modality for Neurological Diseases |
Research Paper: A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease Clinical Review: The convergence of neuromodulation and brain–computer interfaces |