Perelman School of Medicine at the University of Pennsylvania

Topics in Molecular Medicine

Syllabus | Fall 2021

CAMB 542-401 | Topics in Molecular Medicine  

Date Faculty Preceptor Topic Assigned Reading/s

Wednesday, September 1

Roger A. Greenberg, MD, PhD

Synthetic Lethality in Cancer

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors
Clinical Supplement  
Supplementary Reading

Wednesday, September 8

David C. Fajgenbaum, MD, MBA, MSc

The Hyperinflammatory Debate in COVID19 and Therapeutic Implications

Global absence and targeting of protective immune states in severe COVID-19
Clinical Supplement

Monday, September 20

Drew Weissman, MD, PhD

A ‘Universal’ Coronavirus Vaccine

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses
Clinical Supplement I
Clinical Supplement II

Monday, September 27

Sara Rendell, PhD

Heroin and Social Divides

The Textures of Heroin: User Perspectives on “Black Tar” and Powder Heroin in Two US Cities
Clinical Supplement
Supplemental Reading I
Supplemental Reading II

Monday, October 4

Mark Sellmyer, MD, PhD

See-ing Bacteria

Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography
Clinical Supplement

Friday, October 8

Kathryn Davis, MD, M.S.T.R.

Translating Network Statistics to the Bedside in the Treatment of Drug-Resistant Epilepsy

Structural Brain Network Abnormalities and the Probability of Seizure Recurrence After Epilepsy Surgery
Clinical Supplement

Monday, October 18

Marie Guerraty, MD, PhD

The Black Box of HFpEF

Nitrosative stress drives heart failure with preserved ejection fraction
Clinical Supplement

Monday, October 25

William Peranteau, MD

Therapeutic Genome Editing

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
Clinical Supplement

Friday, November 5

Xilma Ortiz-Gonzalez, MD, PhD 

A Precision Medicine Therapeutic

Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease
Clinical Supplement
Supplemental Reading I

Monday, November 15

Rajan Jain, MD

Rahul Kohli,  MD, PhD

Mentor-Mentee Relationships   

Monday, November 29

Jennifer L. Orthman-Murphy, MD, PhD

The Challenges to Developing Reparative Therapy for Multiple Sclerosis

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis
Clinical Supplement
Supplementary Reading

Friday, December 10

Audrey Odom John, MD, PhD

The Mechanistic Basis for Multisystem Inflammatory Syndrome in COVID19

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation
Clinical Supplement
Supplemental Reading I
Supplemental Reading II