Perelman School of Medicine at the University of Pennsylvania

Penn Institute for Immunology

Nuala J. Meyer

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
3400 Spruce Street
8026 Maloney (mail)
5 W. Gates (office)
Philadelphia, PA 19104
Office: 215-662-7049
Fax: 215-614-0869
B.S. (Biology)
Yale University, 1996.
M.D. (Medicine)
University of Chicago, Pritzker School of Medicine, 2000.
M.S. (Translational Research)
University of Pennsylvania, 2011.
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Description of Clinical Expertise

Critical Care Medicine
Acute respiratory distress syndrome
Septic shock
Pulmonary medicine

Description of Research Expertise

Dr. Meyer’s research focuses on identifying genetic and molecular risk factors for acute respiratory distress syndrome and organ dysfunction during critical illness. She seeks to leverage genetic risk profiles to allow the development of personalized therapy for sepsis and ARDS. By directing a cohort of patients with severe sepsis, Dr. Meyer’s research spans the clinical, genetic, and molecular fields, translating human associations with lung injury into mechanistic insights as to how acute lung injury occurs, and transforming this enhanced understanding into improved care for patients.

Selected Publications

Reilly JP, Anderson BJ, Hudock KM, Dunn TG, Kazi A, Charles D, Shashaty MG, Mikkelsen ME, Christie JD, Meyer NJ: Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis. Crit Care 20(1): 222, Jul 2016.

Wang F, Meyer NJ, Walley KR, Russell JA, Feng R: Causal Genetic Inference Using Haplotypes as Instrumental Variables. Genet Epidemiol 40(1): 34-44, Jan 2016.

Palakshappa Jessica A, Meyer Nuala J: Which Patients with ARDS Benefit from Lung Biopsy? Chest 148(4): 1073-1082, Oct 2015.

Anderson BJ, Reilly JP, Shashaty MGS, Tommasini A, Dunn TG, Charles D, Kazi A, Schweickert WD, Mikkelsen ME, Kolson DL, Christie JD, Meyer NJ: Neuron Specific Enolase is an Early Marker of Mortality in Patients with Severe Sepsis. Am J Respir Crit Care 191: A4011, May 2015 Notes: Poster presentation.

Meyer Nuala J, Ferguson Jane F, Feng Rui, Wang Fan, Patel Parth N, Li Mingyao, Xue Chenyi, Qu Liming, Liu Yichuan, Boyd John H, Russell James A, Christie Jason D, Walley Keith R, Reilly Muredach P: A Functional Synonymous Coding Variant in the IL1RN Gene Associates with Survival in Septic Shock. Am. J. Respir. Crit. Care Med. 190(6): 656-664, Sep 2014.

Nuala J Meyer, Rui Feng, Mingyao Li, Yang Zhou, Chau-Chun Sheu, Paula Tejera, Robert Gallop, Scarlett Bellamy, Melanie Rushefski, Paul N. Lanken, Richard Aplenc, Grant E. O'Keefe, Mark M Wurfel, David C Christiani, and Jason D. Christie : IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL1RA. American Journal of Respiratory and Critical Care Medicine 187(9): 950-9, May 2013.

Meyer Nuala J: Beyond Single-Nucleotide Polymorphisms: Genetics, Genomics, and Other 'Omic Approaches to Acute Respiratory Distress Syndrome. Clinics in Chest Medicine 35(4): 673-684, Dec 2014.

Meyer Nuala J, Li Mingyao, Feng Rui, Bradfield Jonathan, Gallop Robert, Bellamy Scarlett, Fuchs Barry D, Lanken Paul N, Albelda Steven M, Rushefski Melanie, Aplenc Richard, Abramova Helen, Atochina-Vasserman Elena N, Beers Michael F, Calfee Carolyn S, Cohen Mitchell J, Pittet Jean-Francois, Christiani David C, O'Keefe Grant E, Ware Lorraine B, May Addison K, Wurfel Mark M, Hakonarson Hakon, Christie Jason D: ANGPT2 Genetic Variant Is Associated with Trauma-associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio. American Journal of Respiratory and Critical Care Medicine 183(10): 1344-53, May 2011.

Meyer, Nuala J and Christie, Jason D: Genetic Heterogeneity and Risk of ARDS. Seminars in Respiratory and Critical Care Medicine 34(4): 459-74, August 2013.

Walley Keith R, Thain Katherine R, Russell James A, Reilly Muredach P, Meyer Nuala J, Ferguson Jane F, Christie Jason D, Nakada Taka-Aki, Fjell Chris D, Thair Simone A, Cirstea Mihai S, Boyd John H: PCSK9 is a critical regulator of the innate immune response and septic shock outcome. Science Translational Medicine 6(258): 258ra143, Oct 2014.

Meyer, Nuala J. : Future Clinical Applications of Genomics to Acute Respiratory Distress Syndrome. Lancet Resp Med 1(10): 793-803, Dec 2013 Notes: Early Online Publication, 19 August 2013.

Meyer NJ, Christie JD: The next generation of ALI genetics: insights into pathophysiology. In: Annual Update in Intensive Care and Emergency Medicine 2011. JL Vincent (eds.). Springer, Page: 97-108, March 2011.

Christie Jason D, Wurfel Mark M, Feng Rui, O'Keefe Grant E, Bradfield Jonathan, Ware Lorraine B, Christiani David C, Calfee Carolyn S, Cohen Mitchell J, Matthay Michael, Meyer Nuala J, Kim Cecilia, Li Mingyao, Akey Joshua, Barnes Kathleen C, Sevransky Jonathan, Lanken Paul N, May Addison K, Aplenc Richard, Maloney James P, Hakonarson Hakon: Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PloS one 7(1): e28268, Jan 2012.

Meyer Nuala J, Daye Z John, Rushefski Melanie, Aplenc Richard, Lanken Paul N, Shashaty Michael G S, Christie Jason D, Feng Rui: SNP-set analysis replicates acute lung injury genetic risk factors. BMC Medical Genetics 13(1): 52, Jun 2012.

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Last updated: 11/09/2017
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