Evgeniy Eruslanov

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Research Assistant Professor of Surgery
Department: Surgery

Contact information
Thoracic Surgery Research Laboratory
3400 Spruce Street, 6 Silverstein
Philadelphia, PA 19104
Education:
MS (Immunology)
Pirogov Russian National Research Medical University , 1999.
PhD (Immunology)
Central Institute for Tuberculosis, Gamaleya’s Institute of Epidemiology and Microbiology Moscow, Russia, 2002.
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Description of Other Expertise


Description of Research Expertise

According to numerous mouse studies, the protumoral and immunosuppressive role of Tumor-Associated Myeloid Cells in cancer is a dominating concept. However, the characterization of tumor microenvironment in cancer patients is still in its infancy and the functional crosstalk between immune and tumor cells in human remains unexplored. My research interests are directed toward understanding the specific functional and regulatory roles of distinct subsets of tumor-infiltrating neutrophils and macrophages in patients with lung cancer.

Selected Publications

Eruslanov EB, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, Conejo-Garcia JR, Feldman M, Albelda SM, Singhal S.: Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J Clin Invest. Nov 2014.

Quatromoni JG, Singhal S, Bhojnagarwala P, Hancock WW, Albelda SM, Eruslanov E.: An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells. J Leukoc Biol. 9(7), Oct 2014.

Eruslanov Evgeniy, Stoffs Taryn, Kim Wan-Ju, Daurkin Irina, Gilbert Scott M, Su Li-Ming, Vieweg Johannes, Daaka Yehia, Kusmartsev Sergei: Expansion of CCR8(+) inflammatory myeloid cells in cancer patients with urothelial and renal carcinomas. Clinical Cancer Research 19(7): 1670-80, Apr 2013.

Predina J, Eruslanov E, Judy B, Kapoor V, Cheng G, Wang LC, Sun J, Moon EK, Fridlender ZG, Albelda S, Singhal S.: Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery. Proceedings of the National Academy of Sciences USA 110(5): E415-24, Jan 2013.

Eruslanov Evgeniy, Neuberger Molly, Daurkin Irina, Perrin George Q, Algood Chester, Dahm Philipp, Rosser Charles, Vieweg Johannes, Gilbert Scott M, Kusmartsev Sergei: Circulating and tumor-infiltrating myeloid cell subsets in patients with bladder cancer. International Journal of Cancer. 130(5): 1109-19, Mar 2012.

Quatromoni JG, Eruslanov E.: Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer. American Journal of Translational Research 4(4): 376-89, 2012.

Daurkin I*, Eruslanov E*,(equal contribution) Stoffs T, Perrin GQ, Algood C, Gilbert SM, Rosser CJ, Su LM, Vieweg J, Kusmartsev S.: Tumor-associated macrophages mediate immunosuppression in the renal cancer microenvironment by activating the 15-lipoxygenase-2 pathway. Cancer Research 71(20): 6400-9, Oct 2011.

Eruslanov E, Daurkin I, Ortiz J, Vieweg J, Kusmartsev S.: Pivotal Advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE₂ catabolism in myeloid cells. Journal of Leukocyte Biology 88(5): 839-48, Nov 2010.

Eruslanov E, Kaliberov S, Daurkin I, Kaliberova L, Buchsbaum D, Vieweg J, Kusmartsev S: Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: a mechanism for immune evasion in cancer. Journal Immunology 182(12): 7548-57, Jun 2009.

Eruslanov EB, Lyadova IV, Kondratieva TK, Majorov KB, Scheglov IV, Orlova MO, Apt AS.: Neutrophil responses to Mycobacterium tuberculosis infection in genetically susceptible and resistant mice. Infection and Immunity 73(3): 1744-53, Mar 2005.

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Last updated: 11/13/2014
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