Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Garret A. FitzGerald, M.D.

Robert L. McNeil, Jr., Professor in Translational Medicine and Therapeutics
Department: Medicine

Contact information
Institute for Translational Medicine and Therapeutics
Room 10-122, Smilow Center for Translational Research (SCTR)
34th and Civic Center Boulevard
Building 421
Philadelphia, PA 19104-5158
Office: (215) 898-1185
Fax: (215) 573-9135
Lab: (215) 898-0255
Education:
MB, BCh (Honors)
University College, Dublin, Ireland, 1974.
Diploma (Statistics)
Trinity College, Dublin, Ireland, 1977.
M.Sc. (Statistics)
University of London, 1979.
M.D. (Medicine)
University College, Dublin, 1980.
D.Sc. (Honorary)
University of Edinburgh, UK, 2004.
D.Sc. (Honorary)
National University of Ireland (150th Anniversary), Dublin, 2004.
M.D. (Honorary)
Johann Wilhelm Goethe University, Frankfurt, Germany, 2007.
D.Sc (Honorary)
King's College, London, UK, 2013.
Permanent link
 
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Selected Publications

Catella-Lawson, F, Reilly MP, Kapoor SC, Cucchiara AJ, De Marco S, Tournier B, Vyas SN, FitzGerald GA: Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. New Engl J Med 345: 1809-1817, 2001.

Cheng Y, Austin SC, Rocca B, Koller BH, Coffman TM, Lawson JA, FitzGerald GA: Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 296: 539-541, 2002 Notes: Commentary on: Vane JR, Biomedicine. Back to an aspirin a day? Science 296: 474-475, 2002.

Grosser T, Yusuff S, Cheskis E, Pack MA, FitzGerald GA: Developmental expression of functional cyclooxygenases in zebrafish. Proc Natl Acad Sci (USA) 99: 8418-8423, 2002 Notes: Commentary on the piece: Prescott SM and Yost HJ. The COXes of Danio: From mechanistic model to experimental therapeutics. Proc. Natl. Acad. Sci. (USA) 99: 9084-9086, 2002.

Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, FitzGerald GA: BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. Plos Biology (Public Library of Science) 2: e377, 2004.

Egan K, Smyth E, Fries S, Rader D, FitzGerald GA: Prostacyclin confers atheroprotection on female mice. Science 306: 1954-1957, 2004.

Cheng Y, Wang M, Yu Y, Lawson J, Funk CD, FitzGerald GA: Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest 116: 1391-1399, 2006.

Wang M, Zukas AM, Hui Y, Ricciotti E, Pure E, FitzGerald GA: Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc Natl Acad Sci USA 103: 14507-14512, 2006.

Curtis AM, Cheng Y, Kapoor S, Reilly D, Price TS, FitzGerald GA: Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci USA 104: 3450-3455, 2007.

Yu Y, Lucitt MB, Stubbe J, Cheng Y, Friis UG, Hansen PB, Jensen BL, Smyth EM, FitzGerald GA: Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proc Natl Acad Sci USA 106: 7985-7990, 2009.

Song WL, Paschos G, Fries S, Reilly MP, Yu Y, Rokach J, Chang CT, Patel P, Lawson JA, FitzGerald GA: Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation. J Biol Chem 284(35): 23636-23643, 2009.

Baggs JE, Price TS, DiTacchio L, Panda S, FitzGerald GA, Hogenesch JB: Network features of the mammalian circadian clock. Plos Biology 7: e52, 2009.

Wang D, Patel VV, Ricciotti E, Zhou R, Levin MD, Gao E, Yu Z, Ferrari VA, Lu MM, Xu J, Zhang H, Hui Y, Cheng Y, Petrenko N, Yu Y, FitzGerald GA: Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci USA 106(18): 7548-7552, 2009.

Hui Y, Ricciotti E, Crichton I, Yu Z, Wang D, Stubbe J, Wang M, Puré E, FitzGerald GA: Targeted deletions of cyclooxygenase-2 and atherogenesis in mice. Circulation 121(24): 2654-2660, 2010.

Grosser T, Yu Y, FitzGerald GA: Emotion recollected in tranquility: Lessons learned from the COX-2 saga (Review). Annu Rev Med 61: 17-33, 2010.

Paschos GK and FitzGerald GA: Circadian clocks and vascular function (Review). Circ Res 106(5): 833-841, 2010.

Skarke C and FitzGerald GA: Training translators for smart drug discovery. Sci Transl Med 2(26): 26cm12, 2010.

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Last updated: 06/26/2013
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