Projects

Consortium on the Genetics of Schizophrenia (COGS-2)

The principal objective of this study is to examine the genetic basis of impairments in core neuropsychological and neurocognitive processes in schizophrenia patients. 

Principal Investigator: Raquel Gur, M.D

Functional Neuroimaging of Reward and Motivation Deficits in Schizophrenia (DAY2)

The overall goal of the study is to relate neural activity in reward-motivation circuits to specific negative symptoms of schizophrenia.

Principal Investigator: Daniel Wolf, M.D., Ph.D.

Neurobiology of Affective Dysfunction - Emotion Expression Study (FACES)

  The purpose of this study is to assess affective flattening and blunting in patients at clinical or genetic risk for developing schizophrenia, with schizophrenia, and healthy controls.

Principal Investigator: Christian Kohler, M.D.

The Neurobiology of Affective Dysfunction in Schizophrenia (AFFECT)

The purpose of this study is to examine neural response facial affect in patients diagnosed with schizophrenia or schizoaffective disorder, as compared to healthy siblings of schizophrenia patients, and to healthy controls from the general population.

Principal Investigator: Raquel Gur, M.D. and Ruben Gur, Ph.D.

Multiplex Genetic Initiative (MGI2)

The study is designed to obtain data for testing hypotheses on genetic liability to schizophrenia.

Principal Investigator: Raquel E. Gur, M.D.

Olfaction and the Neurodevelopment of Psychotic Disorders in Adolescence and Adulthood

The purpose of the proposed project is to study neurodevelopmental processes in schizophrenia during the risk period using tissues obtained from living individuals through olfactory epithelial biopsy.

Principal Investigator: Dr. Karin Borgmann-Winter, M.D.

Olfactory Evoked Potentials and Developmental Neuropathology in Schizophrenia

The objective of this study is to examine olfactory behavioral, electrophysiological and molecular abnormalities in patients with schizophrenia, NAYA genetic risk, NAYA clinical risk and age-matched healthy control subjects.

Principal Investigator: Bruce Turetsky, M.D.

Olfactory Function in Schizophrenia: A Lifespan Analysis

The objective of this study is to examine the neurodevelopmental contributions to chemosensory dysfunction in patients.

Principal Investigator: Paul Moberg, Ph.D.

A Prospective Study of Endophenotypes in At-Risk Youths and Their Siblings (NAYA-K)

The purpose of this study is to obtain baseline clinical measures in youths (ages 10-25) with psychotic disorders, and those at risk for the development of a psychotic disorder in comparison to age matched healthy volunteers.

Principal Investigator: Monica Calkins, Ph.D.

Brain-Behavior and Genetic Studies of the 22q11DS

  This collaborative project with Children’s Hospital of Philadelphia (CHOP) aims to examine the chromosome 22q11.2DS, which is associated with a high risk for psychosis. 

Principal Investigator: Raquel E. Gur, MD, PhD. & Beverly S. Emanuel, MD