Department of Psychiatry
Penn Behavioral Health

Neuropsychiatry Section

Neuropsychiatry Section

Projects

Currently Enrolling Studies:

Brain-Behavior and Genetic Studies of the 22q11DS

  This collaborative project with Children’s Hospital of Philadelphia (CHOP) aims to examine the chromosome 22q11.2DS, which is associated with a high risk for psychosis. 

  • Principal Investigator: Raquel E. Gur, MD, PhD. & Beverly S. Emanuel, MD
  • Study contact: Amy Cassidy, MS

Developmental Trajectories of Negative Symptoms in Schizophrenia (Conte)

The purpose of this study is to examine the brain and behavior as it relates to development and genetics in men and women ages 10 – 30 years old. The project will enroll three study groups: individuals with schizophrenia, individuals at clinical risk for developing psychosis, and healthy controls.

  • Principal Investigator: Raquel Gur, M.D
  • Study Contact: Mary March, MS

Neurodevelopmental Genomics: Philadelphia Neurodevelopmental Cohort (PNC)

This collaborative project with Children’s Hospital of Philadelphia (CHOP) aims to examine the key components of brain development in a sample of 10,000 males and females (ages 8 – 25) in an effort to assess vulnerability to psychotic disorders.

  • Principal Investigator: Raquel E. Gur, MD, PhD. & Hakon Hakonarson, MD PhD
  • Study Contact: Amy Cassidy, MS

Olfactory Evoked Potentials and Developmental Neuropathology in Schizophrenia (OlfDevelopEEG)

The objective of this study is to examine olfactory behavioral, electrophysiological and molecular abnormalities in patients with schizophrenia, genetic risk, clinical risk and age-matched healthy control subjects.

Olfactory Neuroimaging Markers of Heightened Developmental Risk for Schizophrenia (ONM)

The objective of this study is to examine brain function and development and how it relates to an individual’s sense of smell.

  • Principal Investigator: Bruce Turetsky, M.D.
  • Study Contact: Sarah Urick, MS

Neuroimaging of Dimensional Reward Dysfunction in Adolescence (NODRA)

This study aims to better understand how the brain functions relating to rewards, motivation, and decision-making develop during adolescence and young adulthood.We are actively recruiting individuals ages 13-30 with bipolar disorder, schizophrenia, individuals who may be at-risk for schizophrenia, as well as healthy people without psychiatric symptoms.   

  • Principal Investigator: Theodore D. Satterthwaite, M.D., M.A.
  • Study Contact: Lillie Vandekar, BS

Olfaction and the Neurodevelopment of Psychotic Disorders in Adolescence and Adulthood (OlfBiopsy)

The purpose of the proposed project is to study neurodevelopmental processes in schizophrenia during the risk period using tissues obtained from living individuals through olfactory epithelial biopsy.

  • Principal Investigator: Dr. Karin Borgmann-Winter, M.D.
  • Study Contact: Sarah Urick, MS

For Projects currently in Data Analysis and Publication click here