Laboratories and Projects


Applicants for Sabbaticals will apply to the PI of CENT and their proposals will be evaluated by the Executive Committee (see section of Administative Structure). All of the researchers indicated below have indicated their willingness to mentor and instruct trainees of CENT. They will also have incentives to do so because support for the projects will be paid by CENT on a $9,000 per/month basis. This will cover prorated portions of technicians’ salaries, supplies, small equipment and other costs or research.


Research Opportunities at PENN


Research Opportunities at UCLA

Human Brain Imaging


Dr. Dobkin continues to further the interactions of the First International Workshop on Neuroimaging and Stroke Recovery (JC Baron, LG Cohen, SC Cramer, BH Dobkin, H Johansen-Berg, I Loubinoux, RS Marshall, and NS Ward; Cerebrovasc Dis, Jan 2004; 18(3): 260-7). This group meets to improve the standardization of activation paradigms and behavioral measures for neurorehabilitation studies using fMRI, TMS, near-infrared spectroscopy and other methodologies. One goal is to have a growing database of completed imaging studies available to all over the Internet. Collaborations within this network offer a great potential resource for training of fellows, faculty for symposia, and for Web-based continuing interactions with leaders around the world. We would aim to develop existing software for conferencing across sites with former fellows and with world experts in imaging. Data analysis could be carried out among sites and with experts from outside Penn and UCLA. This aim fits well with a funded project, in which Dr. Mazziotta is currently the principal investigator in the International Consortium for Brain Mapping (ICBM) to develop a probabilistic atlas for the human brain. This involves collaborations with eight laboratories in seven countries on four continents. This important project will incorporate, into the normal human probabilistic atlas, functional relationships for each voxel in the brain. If all of the cerebral functions can be assigned in a probabilistic fashion by location, normal brain function will be better defined and injuries to the brain can be assessed in terms of their functional prognosis. With such a system, one can then evaluate plasticity and recovery of function that alters these probabilities on a voxel by voxel basis, thereby defining the system reorganizations that occur as the brain recovers from acute or ongoing injury or with rehabilitation interventions. Additional functional tasks would be applied in normal subjects and in patients with brain injury. The International Collaboration is developing a quantitative neurological scale assessing the major brain functional systems. It would then apply it to individuals with brain injury. When this scale is compared to normal probabilistic maps, probabilistic deficit atlases could be developed and compared to changes over the period of gains with rehabilitation strategies.


Animal Imaging and Plasticity




© copyright 2006, LQJ