Meet a PennMedicine Researcher


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David J. Margolis, M.D., M.S.C.E., Ph.D.

David J. Margolis, MD, MSCE, PhD

David J. Margolis, M.D., M.S.C.E., Ph.D. is a Professor of Dermatology and Professor of Epidemiology. Dr. Margolis has been called “perhaps the nation’s most accomplished dermatoepidemiologist.” His work has transformed understanding of the pathogenesis, prognosis and treatment of chronic wounds, which remain a major health problem.

Dr. Margolis’s  research has demonstrated that easily measured clinical factors such as anatomic depth, wound size, wound duration, and early changes in wound size would predict healing. His innovative clinical assessments are now routinely incorporated into clinical trials designed to explore new treatments of venous legs and diabetic foot ulcers. The outcomes of Dr. Margolis’s research are facilitating the development of safe and efficacious agents for treating chronic wounds. He has revolutionized the approach to conducting trials for chronic wounds, including the use of gene therapy for this important indication, and has conducted research which has played a key role in studying the safety of therapies used by millions of patients. His contributions to the health evaluation sciences are truly comprehensive and durable in their impact.