Meet a PennMedicine Researcher


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Ekaterina L. Grishchuk, PhDEkaterina L. Grishchuk, PhD

Ekaterina L. Grishchuk, PhD, Assistant Professor of Physiology, is the winner of the 2014 Michael S. Brown New Investigator Research Award, which recognizes emerging faculty investigators engaged in innovative discoveries.  With a combination of cellular, molecular and biophysical approaches, Dr. Grishchuk has made outstanding contributions to the understanding of mechanisms that drive chromosomal motion during mitosis.

Her work at Penn has focused on three themes. The first explores different molecular tethers that couple kinetochores to microtubules in the mitotic spindle, and how these protein complexes allow the cell to use the energy released by microtubule depolymerization to drive chromosome motility. The second focus of her work incorporates single molecule approaches to investigate the kinetochore kinesin motor protein CENP-E. Finally, she has developed detailed quantitative models for kinetochore dynamics during mitosis. Her work in these areas has produced some of the most mechanistic modeling of kinetochore-microtubule interface.