Perelman School of Medicine at the University of Pennsylvania

Arterial Hemodynamics and Cardiovascular Core Lab

Ongoing Research


KNO3CK OUT HFpEF Trial

Effect of KNO3 Compared to KCl on Oxygen UpTake in Heart Failure with Preserved Ejection Fraction
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The goal of this randomized double-blinded cross-over trial is to test the hypothesis that potassium nitrate will improve exercise capacity, quality of life, and key physiologic adaptations to exercise in patients with heart failure and preserved ejection fraction (HFpEF). Key endpoints in the trial include aerobic capacity, quality of life, vasodilatory reserve, the vasodilatory reserve in exercising muscle, LV systolic and diastolic function, muscle oxidative capacity and late systolic left ventricular afterload, which induces LV diastolic dysfunction and remodeling.

PI: Julio A. Chirinos
R01 HL121510
Funded by a grant from the National Institutes of Health


Predicting 30-Day Readmissions for Acute Decompensated Heart Failure

In this study, we are investigating a novel hemodynamic sensor to assess arterial hemodynamics in an ambulatory fashion in patients with a recent episode of decompensated heart failure.

PI: Julio A. Chirinos 
Sponsor and Collaborator Institution: Microsoft Research


BMS CV002004

A Longitudinal Evaluation of Disease & Fibrosis Biomarkers in Different Groups of Heart Failure Patients to Enhance the Early Clinical Development of Compounds with Anti-fibrotic Activity in the Heart

This multicenter study aims to characterize cardiac structure and function (in particular, myocardial interstitial fibrosis) in patients with hypertension, heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. Our core lab quantifies all MRI and arterial hemodynamic data for this study.

Core Lab Director: Julio A. Chirinos 
Funded by Bristol-Myers-Squibb


American College of Radiology Network 4008

Heart Failure, Left Ventricular Remodeling, and Circulating Nitric Oxide Metabolites
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Co-PIs: Julio A. Chirinos, Scott R. Akers
Core Lab Director: Julio A. Chirinos


ISMN in CKD

Targeting Central Pulsatile Hemodynamics in Chronic Kidney Disease
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R56 HL 124073-01A1
Funded by a grant from the National Institutes of Health


PISA

Penn Iceland Sleep Apnea Study

In this study, we are assessing the effects of sleep apnea on cardiovascular structure and function, assessed with a combination of arterial tonometry and cardiac MRI. The study occurs at the University of Pennsylvania and the University of Iceland.

Program Project PI: Allan Pack; Project Leader: Samuel T. Kuna
Core Lab Director: Julio A. Chirinos


MESA arterial Stiffness Substudy

Relationships between central arterial pressure profiles, target organ damage and cardiovascular risk: The Multiethnic Study of Atherosclerosis – Revisited
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Core Lab Director: Julio A. Chirinos


Ventricular-arterial interactions advanced phenotyping cohort study

We are currently performing a study at the CMJC VA Medical Center in which various novel MRI cardiovascular phenotypes are being assess in patients with hypertension, heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. Our core lab quantifies all MRI and arterial hemodynamic data for this study.

PI and Core Lab Director: Julio A. Chirinos

CMJCVAMC


Assessment of ventricular-arterial interactions in the echocardiographic laboratory

Relationships between central arterial pressure profiles, target organ damage and cardiovascular risk: The Multiethnic Study of Atherosclerosis – Revisited

Core Lab Director: Julio A. Chirinos


Asklepios Study

Relationships between central arterial pressure profiles, target organ damage and cardiovascular risk: The Multiethnic Study of Atherosclerosis – Revisited
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We collaborate closely with our colleagues Ernst Rietzschel, Patrick Segers and Thierry Gillebert, Marc De Buyzere and others at the University of Ghent. Dr. Rietzschel has his collaborators are performing the Asklepios study, which is a large cohort study of cardiovascular disease and aging in middle-age. We have collaborated with the U. Ghent team in various substudies of ventricular and arterial function.

Core Lab Director: Julio A. Chirinos


INTERVENCION Trial

This randomized trial is assessing the effect of high altitude on the hemodynamic response to various antihypertensive regiments. We collaborate with Dr. Josefina Medina at the Santa Maria Catholic University in Peru, and we have performed core lab analyses of arterial function for the INTERVENCION trial.

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Vascular effects of dietary salt in humans with salt-resistant BP

We collaborate with Drs. Edwards and Farquhar at the U. of Delaware in this study assessing the deleterious effects of dietary salt. We provide support for the analysis of central arterial hemodynamic data collected. 

1R01HL104106 (PI:  Edwards, Farquhar)