Publications

Featured Publication

Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Alzheimer’s Disease Neuroimaging Initiative (ADNI), David A. Wolk & Ilya M. Nasrallah

Abstract: Objective: Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in ¹⁸F-flortaucipir vs. ¹⁸F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (N_M) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/N_M clusters with differing limbic and cortical patterns. The canonical group was defined as the T/N_M pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected relative to T and displayed better cognition than the canonical group. Groups susceptible to T had more hypometabolism than expected given T and exhibited worse cognitive decline, with imaging and clinical measures concordant with non-AD copathologies. Together, T/N_M mismatch reveals distinct imaging signatures with pathobiological and prognostic implications for AD.

Read the Full Publication here.

ADCC-related Publications

• Blood extracellular vesicles carrying synaptic function- and brain-related proteins as potential biomarkers for Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Jul 2; Authors: Tian C, Stewart T, Hong Z, Guo Z, Aro P, Soltys D, Pan C, Peskind ER, Zabetian CP, Shaw LM, Galasko D, Quinn JF, Shi M, Zhang J, Alzheimer's Disease Neuroimaging Initiative.

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• Positron Emission Tomography-Based Assessment of Cognitive Impairment and Dementias, Critical Role of Fluorodeoxyglucose in such Settings.
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• Aducanumab-Related Amyloid-Related Imaging Abnormalities: Paean or Lament?
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• Human Metabotropic Glutamate Receptor 5 Antibodies Alter Receptor Levels and Behavior in Mice.
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• [Formula: see text] Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study.
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• Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Jun 29; Authors: Weiner MW, Harvey D, Landau SM, Veitch DP, Neylan TC, Grafman JH, Aisen PS, Petersen RC, Jack CR Jr, Tosun D, Shaw LM, Trojanowski JQ, Saykin AJ, Hayes J, De Carli C, Alzheimer's Disease Neuroimaging Initiative and the Department of Defense Alzheimer's Disease Neuroimaging Initiative.

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  Journal of the American Medical Directors Association. 2022 Jun 27; Authors: Candon M, Strominger J, Gotlieb E, Maust DT

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  Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. 2022 Jun 24; Authors: Sloane KL, Mefford JA, Zhao Z, Xu M, Zhou G, Fabian R, Wright AE, Glenn S

• Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread.
  Neuropathology and applied neurobiology. 2022 Jun 21;:e12829; Authors: Pang CCC, Sørensen MH, Lee K, Luk KC, Trojanowski JQ, Lee VMY, Noble W, Chang RCC

• Neuroergonomic assessment of developmental coordination disorder.
  Scientific reports. 2022 Jun 17;12(1):10239; Authors: Joshi S, Weedon BD, Esser P, Liu YC, Springett DN, Meaney A, Inacio M, Delextrat A, Kemp S, Ward T, Izadi H, Dawes H, Ayaz H

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  Journal of neurotrauma. 2022 Jun 15; Authors: Albrecht JS, Gardner RC, Wiebe D, Bahorik A, Xia F, Yaffe K

• Brain Structure Among Middle-aged and Older Adults With Long-standing Type 1 Diabetes in the DCCT/EDIC Study.
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• Predicting Amyloid Positivity in Cognitively Unimpaired Older Adults: A Machine Learning Approach Using A4 Data.
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  Progress in neurobiology. 2022 Jun 13;216:102307; Authors: Miner KM, Jamenis AS, Bhatia TN, Clark RN, Rajasundaram D, Sauvaigo S, Mason DM, Posimo JM, Abraham N, DeMarco BA, Hu X, Stetler RA, Chen J, Sanders LH, Luk KC, Leak RK

• Neural consequences of chronic sleep disruption.
  Trends in neurosciences. 2022 Jun 9; Authors: Zamore Z, Veasey SC

• Disclosing Alzheimer Disease Biomarker Results to Research Participants.
  JAMA neurology. 2022 Jun 6; Authors: Grill JD, Karlawish J

• Using Informatics to Engage Vulnerable Populations in Research: Lessons Learned from the COVID-19 Pandemic.
  Studies in health technology and informatics. 2022 Jun 6;290:858-861; Authors: Demiris G, Chung J, Turner AM

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• Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting.
  NPJ Parkinson's disease. 2022 Jun 2;8(1):68; Authors: Blömeke L, Pils M, Kraemer-Schulien V, Dybala A, Schaffrath A, Kulawik A, Rehn F, Cousin A, Nischwitz V, Willbold J, Zack R, Tropea TF, Bujnicki T, Tamgüney G, Weintraub D, Irwin D, Grossman M, Wolk DA, Trojanowski JQ, Bannach O, Chen-Plotkin A, Willbold D

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  BMC genomics. 2022 Jun 2;23(Suppl 4):414; Authors: Lee B, Yao X, Shen L, Alzheimer’s Disease Neuroimaging Initiative.

• Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.
  Diabetologia. 2022 Jun 2; Authors: Merino B, Casanueva-Álvarez E, Quesada I, González-Casimiro CM, Fernández-Díaz CM, Postigo-Casado T, Leissring MA, Kaestner KH, Perdomo G, Cózar-Castellano I

• An analytical solution simulating growth of Lewy bodies.
  Mathematical medicine and biology : a journal of the IMA. 2022 Jun 2; Authors: Kuznetsov IA, Kuznetsov AV

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  Lifetime data analysis. 2022 Jun 2; Authors: Vo TT, Davies-Kershaw H, Hackett R, Vansteelandt S

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  The Nursing clinics of North America. 2022 Jun;57(2):233-244; Authors: Cacchione PZ, Spurlock W, Richards K, Harris M

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  Network neuroscience (Cambridge, Mass.). 2022 Jun;6(2):320-338 Epub 2022 Jun 1; Authors: Rodriguez-Cruces R, Royer J, Larivière S, Bassett DS, Caciagli L, Bernhardt BC

• Racial and Ethnic Disparities in Dementia Care: Next Steps.
  JAMA network open. 2022 Jun 1;5(6):e2216267; Authors: Coe NB, Lee C

• Ethnic differences in the frequency of β-amyloid deposition in cognitively normal individuals.
  Neurobiology of aging. 2022 Jun;114:27-37 Epub 2022 Mar 7; Authors: Kim J, Jung SH, Choe YS, Kim S, Kim B, Kim HR, Son SJ, Hong CH, Na DL, Kim HJ, Cho SJ, Won HH, Seo SW, Alzheimer's Disease Neuroimaging Initiative.

• Recruiting Persons with Dementia and Caregivers in a Clinical Trial: Dyads Perceptions.
  Western journal of nursing research. 2022 Jun;44(6):557-566 Epub 2021 Apr 17; Authors: McPhillips MV, Petrovsky DV, Brewster GS, Li J, Gooneratne NS, Hodgson NA, Sefcik JS

• An on-chip photonic deep neural network for image classification.
  Nature. 2022 Jun;606(7914):501-506 Epub 2022 Jun 1; Authors: Ashtiani F, Geers AJ, Aflatouni F

• Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities.
  Periodontology 2000. 2022 Jun;89(1):215-230 Epub 2022 Mar 4; Authors: Hajishengallis G, Li X, Divaris K, Chavakis T

• Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice.
  Aging cell. 2022 Jun;21(6):e13598 Epub 2022 Apr 30; Authors: Hafycz JM, Strus E, Naidoo N

• Measuring Sex and Gender in Aging and Alzheimer's Research: Results of a National Survey.
  The journals of gerontology. Series B, Psychological sciences and social sciences. 2022 Jun 1;77(6):1005-1016; Authors: Stites SD, Cao H, Harkins K, Flatt JD

• MRI evaluation of cerebral metabolic rate of oxygen (CMRO₂) in obstructive sleep apnea.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2022 Jun;42(6):1049-1060 Epub 2022 Jan 7; Authors: Wu PH, Rodríguez-Soto AE, Wiemken A, Englund EK, Rodgers ZB, Langham MC, Schwab RJ, Detre JA, Guo W, Wehrli FW

• Cognitive impairment associated with greater care intensity during home health care.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Jun;18(6):1100-1108 Epub 2021 Aug 24; Authors: Burgdorf JG, Amjad H, Bowles KH

• Postacute care outcomes in home health or skilled nursing facilities in patients with a diagnosis of dementia.
  Health services research. 2022 Jun;57(3):497-504 Epub 2021 Aug 12; Authors: Burke RE, Xu Y, Ritter AZ, Werner RM

• Longitudinal Trajectories and Correlates of Post-Caregiving Depressive Symptoms in Former Caregivers of Persons With Alzheimer's Disease or a Related Dementia.
  The American journal of hospice & palliative care. 2022 Jun;39(6):725-736 Epub 2021 Sep 3; Authors: Magan KC, Hirschman KB, Starr LT, Meghani SH

• Rates of longitudinal change in ¹⁸ F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Jun;18(6):1235-1247 Epub 2021 Sep 13; Authors: Phillips JS, Nitchie FJ 4th, Da Re F, Olm CA, Cook PA, McMillan CT, Irwin DJ, Gee JC, Dubroff JG, Grossman M, Nasrallah IM, Alzheimer's Disease Neuroimaging Initiative.

• Longitudinal trajectories of insomnia symptoms among college students during the COVID-19 lockdown in China.
  Journal of psychosomatic research. 2022 Jun;157:110795 Epub 2022 Mar 26; Authors: Wang D, Zhao J, Zhai S, Huang S, Yang Z, Pan Y, Liu X, Fan F

• Chronic Light-Distorted Glutamate-Cortisol Signaling, Behavioral and Histological Markers, and Induced Oxidative Stress and Dementia: An Amelioration by Melatonin.
  ACS chemical neuroscience. 2022 Jun 1;13(11):1604-1614 Epub 2022 May 12; Authors: Sarena P, Sharma A, Urmera MT, Tambuwala MM, Aljabali AAA, Chellappan DK, Dua K, Taliyan R, Goyal R

• Epilepsy Course and Developmental Trajectories in <i>STXBP1</i>-DEE.
  Neurology. Genetics. 2022 Jun;8(3):e676 Epub 2022 May 31; Authors: Balagura G, Xian J, Riva A, Marchese F, Ben Zeev B, Rios L, Sirsi D, Accorsi P, Amadori E, Astrea G, Baldassari S, Beccaria F, Boni A, Budetta M, Cantalupo G, Capovilla G, Cesaroni E, Chiesa V, Coppola A, Dilena R, Faggioli R, Ferrari A, Fiorini E, Madia F, Gennaro E, Giacomini T, Giordano L, Iacomino M, Lattanzi S, Marini C, Mancardi MM, Mastrangelo M, Messana T, Minetti C, Nobili L, Papa A, Parmeggiani A, Pisano T, Russo A, Salpietro V, Savasta S, Scala M, Accogli A, Scelsa B, Scudieri P, Spalice A, Specchio N, Trivisano M, Tzadok M, Valeriani M, Vari MS, Verrotti A, Vigevano F, Vignoli A, Toonen R, Zara F, Helbig I, Striano P

• Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses.
  Cancer cell. 2022 May 30; Authors: Lyudovyk O, Kim JY, Qualls D, Hwee MA, Lin YH, Boutemine SR, Elhanati Y, Solovyov A, Douglas M, Chen E, Babady NE, Ramanathan L, Vedantam P, Bandlamudi C, Gouma S, Wong P, Hensley SE, Greenbaum B, Huang AC, Vardhana SA

• Trajectories of mental health status during the early phase pandemic in China: A longitudinal study on adolescents living in the community with confirmed cases.
  Psychiatry research. 2022 May 28;314:114646; Authors: Wang D, Zhao J, Zhai S, Chen H, Liu X, Fan F

• Changes in suicidal ideation and related influential factors in college students during the COVID-19 lockdown in China.
  Psychiatry research. 2022 May 28;314:114653; Authors: Huang S, Wang D, Zhao J, Chen H, Ma Z, Pan Y, Liu X, Fan F

• Fluent molecular mixing of Tau isoforms in Alzheimer's disease neurofibrillary tangles.
  Nature communications. 2022 May 27;13(1):2967; Authors: Dregni AJ, Duan P, Xu H, Changolkar L, El Mammeri N, Lee VM, Hong M

• Effect of Deintensifying Diabetes Medications on Negative Events in Older Veteran Nursing Home Residents.
  Diabetes care. 2022 May 27; Authors: Niznik JD, Zhao X, Slieanu F, Mor MK, Aspinall SL, Gellad WF, Ersek M, Hickson RP, Springer SP, Schleiden LJ, Hanlon JT, Thorpe JM, Thorpe CT

• Establishing a Framework for Gathering Structural and Social Determinants of Health in Alzheimer's Disease Research Centers.
  The Gerontologist. 2022 May 26;62(5):694-703; Authors: Stites SD, Midgett S, Mechanic-Hamilton D, Zuelsdorff M, Glover CM, Marquez DX, Balls-Berry JE, Streitz ML, Babulal G, Trani JF, Henderson JN, Barnes LL, Karlawish J, Wolk DA

• Artificial Intelligence and Circulating Cell-Free DNA Methylation Profiling: Mechanism and Detection of Alzheimer's Disease.
  Cells. 2022 May 25;11(11); Authors: Bahado-Singh RO, Radhakrishna U, Gordevičius J, Aydas B, Yilmaz A, Jafar F, Imam K, Maddens M, Challapalli K, Metpally RP, Berrettini WH, Crist RC, Graham SF, Vishweswaraiah S

• Cerebral Microvascular Pathology Is a Common Endophenotype Between Traumatic Brain Injury, Cardiovascular Disease, and Dementia: A Hypothesis and Review.
  Cureus. 2022 May;14(5):e25318 Epub 2022 May 25; Authors: Swanson RL 2nd, Acharya NK, Cifu DX

• Emergency and post-emergency care of older adults with Alzheimer's disease/Alzheimer's disease related dementias.
  Journal of the American Geriatrics Society. 2022 May 25; Authors: Hill JD, Schmucker AM, Siman N, Goldfeld KS, Cuthel AM, Chodosh J, Bouillon-Minois JB, Grudzen CR

• Non-invasive brain stimulation and neuroenhancement.
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• Disentangling tau and brain atrophy cluster heterogeneity across the Alzheimer's disease continuum.
  Alzheimer's & dementia (New York, N. Y.). 2022;8(1):e12305 Epub 2022 May 23; Authors: Toledo JB, Liu H, Grothe MJ, Rashid T, Launer L, Shaw LM, Snoussi H, Heckbert S, Weiner M, Trojanwoski JQ, Seshadri S, Habes M, & for the Alzheimer's Disease Neuroimaging Initiative.

• Plasma MIA, CRP, and Albumin Predict Cognitive Decline in Parkinson's Disease.
  Annals of neurology. 2022 May 20; Authors: Shen J, Amari N, Zack R, Skrinak RT, Unger TL, Posavi M, Tropea TF, Xie SX, Van Deerlin VM, Dewey RB Jr, Weintraub D, Trojanowski JQ, Chen-Plotkin AS

• Identifying Alzheimer's genes via brain transcriptome mapping.
  BMC medical genomics. 2022 May 19;15(Suppl 2):116; Authors: Baik JY, Kim M, Bao J, Long Q, Shen L, Alzheimer’s Disease Neuroimaging Initiative.

• Autosomal dominant and sporadic late onset Alzheimer disease share a common in vivo pathophysiology.
  Brain : a journal of neurology. 2022 May 17; Authors: Morris JC, Weiner M, Xiong C, Beckett L, Coble D, Saito N, Aisen PS, Allegri R, Benzinger TLS, Berman SB, Cairns NJ, Carrillo MC, Chui HC, Chhatwal JP, Cruchaga C, Fagan AM, Farlow M, Fox NC, Ghetti B, Goate AM, Gordon BA, Graff-Radford N, Day GS, Hassenstab J, Ikeuchi T, Jack CR, Jagust WJ, Jucker M, Levin J, Massoumzadeh P, Masters CL, Martins R, McDade E, Mori H, Noble JM, Petersen RC, Ringman JM, Salloway S, Saykin AJ, Schofield PR, Shaw LM, Toga AW, Trojanowski JQ, Vöglein J, Weninger S, Bateman RJ, Buckles VD, Dominantly Inherited Alzheimer Network and the Alzheimer’s Disease Neuroimaging Initiative.

• Alzheimer's Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects- Atherosclerosis for a Start.
  Journal of Alzheimer's disease : JAD. 2022 May 16; Authors: Høilund-Carlsen PF, Revheim ME, Alavi A

• Efficacy of an Experimental Gonococcal Lipooligosaccharide Mimitope Vaccine Requires Terminal Complement.
  The Journal of infectious diseases. 2022 May 16;225(10):1861-1864; Authors: Lewis LA, Gulati S, Zelek WM, Morgan BP, Song WC, Zheng B, Nowak N, DeOliveira RB, Sanchez B, DeSouza Silva L, Schuurman J, Beurskens F, Ram S, Rice PA

• Anxiety-like behavior and anxiolytic treatment in the Rett syndrome natural history study.
  Journal of neurodevelopmental disorders. 2022 May 14;14(1):31; Authors: Buchanan CB, Stallworth JL, Joy AE, Dixon RE, Scott AE, Beisang AA, Benke TA, Glaze DG, Haas RH, Heydemann PT, Jones MD, Lane JB, Lieberman DN, Marsh ED, Neul JL, Peters SU, Ryther RC, Skinner SA, Standridge SM, Kaufmann WE, Percy AK

• Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.
  Brain : a journal of neurology. 2022 May 13; Authors: Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, Hernandez Saucedo H, Widaman KF, Buckley RF, Properzi MJ, Mormino EC, Yang HS, Harrison TM, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Zhong X, Raghavan NS, Vardarajan BN, Alzheimer’s Disease Neuroimaging Initiative (ADNI)., Alzheimer’s Disease Genetics Consortium (ADGC)., A4 Study Team., Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg GD, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Cuccaro ML, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ

• Lateralized <i>ante mortem</i> and <i>post mortem</i> pathology in a case of Lewy body disease with corticobasal syndrome.
  Alzheimer's & dementia (New York, N. Y.). 2022;8(1):e12294 Epub 2022 May 11; Authors: Coughlin DG, Coslett HB, Peterson C, Phillips JS, McMillan C, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ

• Confirming Parkinson Disease Diagnosis: Patterns of Diagnostic Changes by Movement Disorder Specialists.
  Parkinson's disease. 2022;2022:5535826 Epub 2022 May 9; Authors: Keshtkarjahromi M, Abraham DS, Gruber-Baldini AL, Schrader K, Reich SG, Savitt JM, Von Coelln R, Shulman LM

• Disentangling Alzheimer's disease neurodegeneration from typical brain ageing using machine learning.
  Brain communications. 2022;4(3):fcac117 Epub 2022 May 7; Authors: Hwang G, Abdulkadir A, Erus G, Habes M, Pomponio R, Shou H, Doshi J, Mamourian E, Rashid T, Bilgel M, Fan Y, Sotiras A, Srinivasan D, Morris JC, Albert MS, Bryan NR, Resnick SM, Nasrallah IM, Davatzikos C, Wolk DA, from the iSTAGING consortium., ADNI.

• Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 May 4;42(18):3868-3877 Epub 2022 Mar 22; Authors: Chen M, Ohm DT, Phillips JS, McMillan CT, Capp N, Peterson C, Xie E, Wolk DA, Trojanowski JQ, Lee EB, Gee J, Grossman M, Irwin DJ

• Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.
  Brain : a journal of neurology. 2022 May 2; Authors: Caciagli L, Paquola C, He X, Vollmar C, Centeno M, Wandschneider B, Braun U, Trimmel K, Vos SB, Sidhu MK, Thompson PJ, Baxendale S, Winston GP, Duncan JS, Bassett DS, Koepp MJ, Bernhardt BC

• Dental management of a pediatric patient with Kohlschutter-Tonz syndrome: A case report.
  Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. 2022 May;42(3):308-311 Epub 2021 Nov 12; Authors: Kulkarni R, Caster JM, Robin A, Hajishengallis E, Stoopler ET, Tanaka TI

• Use of Post-Acute Care by Medicare Beneficiaries With a Diagnosis of Dementia.
  Journal of the American Medical Directors Association. 2022 May;23(5):877-879.e3 Epub 2021 Oct 10; Authors: Burke RE, Xu Y, Ritter AZ

• Patients asking about APOE gene test results? Here's what to tell them.
  The Journal of family practice. 2022 May;71(4):E1-E7; Authors: Stites SD, Vogt NM, Blacker D, Rumbaugh M, Parker MW, Advisory Group on Risk Evidence Education for Dementia (AGREED).

• Characteristics of clinical relapses and patient-oriented long-term outcomes of patients with anti-N-methyl-D-aspartate receptor encephalitis.
  Journal of neurology. 2022 May;269(5):2486-2492 Epub 2021 Oct 6; Authors: Hirose S, Hara M, Kamei S, Dalmau J, Nakajima H

• Subtypes of Alzheimer's disease: questions, controversy, and meaning.
  Trends in neurosciences. 2022 May;45(5):342-345 Epub 2022 Feb 25; Authors: Vogel JW, Hansson O

• Itavastatin and resveratrol increase triosephosphate isomerase protein in a newly identified variant of TPI deficiency.
  Disease models & mechanisms. 2022 May 1;15(5) Epub 2022 May 17; Authors: VanDemark AP, Hrizo SL, Eicher SL, Kowalski J, Myers TD, Pfeifer MR, Riley KN, Koeberl DD, Palladino MJ

• Phases of volume loss in patients with known frontotemporal lobar degeneration spectrum pathology.
  Neurobiology of aging. 2022 May;113:95-107 Epub 2022 Feb 24; Authors: Burke SE, Phillips JS, Olm CA, Peterson CS, Cook PA, Gee JC, Lee EB, Trojanowski JQ, Massimo L, Irwin DJ, Grossman M

• Out-of-pocket costs attributable to dementia: A longitudinal analysis.
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• Interpersonal Correlates of Dementia Caregivers' Emotional Support Networks: Considering Family History.
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• Genetics of glutamate and its receptors in autism spectrum disorder.
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• Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression.
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• Neurocognitive outcomes of children with non-syndromic single-suture craniosynostosis.
  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2022 May;38(5):893-901 Epub 2022 Feb 22; Authors: Kalmar CL, Lang SS, Heuer GG, Schreiber JE, Tucker AM, Swanson JW, Beslow LA

• Proposed research criteria for prodromal behavioural variant frontotemporal dementia.
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• Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy.
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• Multiple Cortical to Striatal Accumulation Trajectories of β-Amyloid: Do All Roads Lead to Rome?
  Neurology. 2022 Apr 26;98(17):695-696 Epub 2022 Mar 25; Authors: Vogel JW, Tosun D

• Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders.
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• Activation of a Locus Coeruleus to Dorsal Hippocampus Noradrenergic Circuit Facilitates Associative Learning.
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• Flying under the radar: TMEM106B(120-254) fibrils break out in diverse neurodegenerative disorders.
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• Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro.
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• Volume, density, and thickness brain abnormalities in mild cognitive impairment: an ALE meta-analysis controlling for age and education.
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• Neurobehavioral Dimensions of Prader Willi Syndrome: Relationships Between Sleep and Psychosis-Risk Symptoms.
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• Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.
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• Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change.
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• Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective.
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• Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging.
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• Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration.
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• Neuronal genetic rescue normalizes brain network dynamics in a lysosomal storage disorder despite persistent storage accumulation.
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• Association of Brain Volumes and White Matter Injury With Race, Ethnicity, and Cardiovascular Risk Factors: The Multi-Ethnic Study of Atherosclerosis.
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• Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function.
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• Letter to the editor: in response to 'association between widespread pain and dementia, Alzheimer's disease and stroke: a cohort study from the Framingham Heart Study'.
  Regional anesthesia and pain medicine. 2022 Apr;47(4):270 Epub 2021 Nov 1; Authors: Barash J, Kofke WA, Badiola I

• Development of a Comprehensive Battery to Collect Social and Structural Determinants of Health (SSDOH) in Cognitively Normal or Very Mildly Impaired Persons.
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• Brain charts for the human lifespan.
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• New insights into the genetic etiology of Alzheimer's disease and related dementias.
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• Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
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• Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease.
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• Dementia is a surrogate for frailty in hip fracture mortality prediction.
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• De novo DHDDS variants cause a neurodevelopmental and neurodegenerative disorder with myoclonus.
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• The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.
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• Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases.
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• Cognitive Outcome 1 Year After Mild Traumatic Brain Injury: Results From the TRACK-TBI Study.
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• You've Got a Friend in Me: How Cognitively Unimpaired Older Adults Select a Study Partner to Participate with Them in Alzheimer's Disease Research.
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• Public spending on acute and long-term care for Alzheimer's disease and related dementias.
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• TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.
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• Medial Temporal Lobe Networks in Alzheimer's Disease: Structural and Molecular Vulnerabilities.
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• Defining cognitive impairment in amyotrophic lateral sclerosis: an evaluation of empirical approaches.
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• Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization.
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• An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion.
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• Dementia and the Risk of Periodontitis: A Population-Based Cohort Study.
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• Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study.
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• Analysis of differential gene expression and transcript usage in hippocampus of Apoe null mutant mice: Implications for Alzheimer's disease.
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• Mental status changes during elexacaftor/tezacaftor / ivacaftor therapy.
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• Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
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• Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
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• Is there a difference between terminal lucidity and paradoxical lucidity?
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• The Association of Poverty With Well-being and Dementia Outcomes-It's Not All About the Money.
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• Plasticity impairment exposes CA3 vulnerability in a hippocampal network model of mild traumatic brain injury.
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• Thalamic Dorsomedial Nucleus Free Water Correlates with Cognitive Decline in Parkinson's Disease.
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• Bringing Alzheimer Disease Testing and Results Disclosure Into the 21st Century Cures Act.
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• Feasibility and acceptability of a web-based advance care plan for dementia.
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• Medicare Claims Data Underestimate Hallucinations in Older Adults With Dementia.
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• Independent associations between sleep duration, gamma gap, and cognitive function among older adults: Results from the NHANES 2013-2014.
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• Association of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes.
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• What is paradoxical lucidity? The answer begins with its definition.
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• Potential mechanisms underlying lithium treatment for Alzheimer's disease and COVID-19.
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• TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A.
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• Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study.
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• Blood Biomarkers in Brain Injury Medicine.
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• Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos &amp; Alzheimer's Symposium.
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• Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
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• The posterior dominant rhythm: an electroencephalographic biomarker for cognitive recovery after general anaesthesia.
  British journal of anaesthesia. 2022 Feb 16; Authors: Labonte AK, Kafashan M, Huels ER, Blain-Moraes S, Basner M, Kelz MB, Mashour GA, Avidan MS, Palanca BJA, ReCCognition Study Group.

• Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure.
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• Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques.
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• Longitudinal trajectories of depression and anxiety among adolescents during COVID-19 lockdown in China.
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• Genome-wide association study of brain arteriolosclerosis.
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• Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Feb 9; Authors: Godrich D, Martin ER, Schellenberg G, Pericak-Vance MA, Cuccaro M, Scott WK, Kukull W, Montine T, Beecham GW

• Biased Orientation and Color Tuning of the Human Visual Gamma Rhythm.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 Feb 9;42(6):1054-1067 Epub 2021 Dec 28; Authors: Li Y, Bosking W, Beauchamp MS, Sheth SA, Yoshor D, Bartoli E, Foster BL

• Effects of Medicare comprehensive medication review on racial/ethnic disparities in nonadherence to statin medications among patients with Alzheimer's Disease: an observational analysis.
  BMC health services research. 2022 Feb 7;22(1):159; Authors: Browning JA, Tsang CCS, Dong X, Wan JY, Chisholm-Burns MA, Finch CK, Tsao JW, Liu C, Wang J

• Altered functional brain dynamics in chromosome 22q11.2 deletion syndrome during facial affect processing.
  Molecular psychiatry. 2022 Feb;27(2):1158-1166 Epub 2021 Oct 22; Authors: Cornblath EJ, Mahadevan A, He X, Ruparel K, Lydon-Staley DM, Moore TM, Gur RC, Zackai EH, Emanuel B, McDonald-McGinn DM, Wolf DH, Satterthwaite TD, Roalf DR, Gur RE, Bassett DS

• Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.
  Annals of clinical and translational neurology. 2022 Feb;9(2):155-170 Epub 2022 Feb 1; Authors: Berger M, Browndyke JN, Cooter Wright M, Nobuhara C, Reese M, Acker L, Bullock WM, Colin BJ, Devinney MJ, Moretti EW, Moul JW, Ohlendorf B, Laskowitz DT, Waligorska T, Shaw LM, Whitson HE, Cohen HJ, Mathew JP, MADCO-PC Investigators.

• Clinical and Demographic Profiles of Home Care Patients With Alzheimer's Disease and Related Dementias: Implications for Information Transfer Across Care Settings.
  Journal of applied gerontology : the official journal of the Southern Gerontological Society. 2022 Feb;41(2):534-544 Epub 2021 Mar 20; Authors: Ryvicker M, Barrón Y, Shah S, Moore SM, Noble JM, Bowles KH, Merrill J

• Suicide risk in first year after dementia diagnosis in older adults.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Feb;18(2):262-271 Epub 2021 May 25; Authors: Schmutte T, Olfson M, Maust DT, Xie M, Marcus SC

• The relationship between social isolation and anxiety in people with cognitive impairment in the United States.
  International journal of geriatric psychiatry. 2022 Feb;37(2); Authors: Hwang Y, Massimo L, Aryal S, Hodgson NA

• Biomarker-Based Prediction of Longitudinal Tau Positron Emission Tomography in Alzheimer Disease.
  JAMA neurology. 2022 Feb 1;79(2):149-158; Authors: Leuzy A, Smith R, Cullen NC, Strandberg O, Vogel JW, Binette AP, Borroni E, Janelidze S, Ohlsson T, Jögi J, Ossenkoppele R, Palmqvist S, Mattsson-Carlgren N, Klein G, Stomrud E, Hansson O

• Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Feb;18(2):294-306 Epub 2021 Jun 20; Authors: Zhang X, Farrell JJ, Tong T, Hu J, Zhu C, Alzheimer's Disease Sequencing Project., Wang LS, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA

• Predictors of multi-domain cognitive decline following DBS for treatment of Parkinson's disease.
  Parkinsonism & related disorders. 2022 Feb;95:23-27 Epub 2021 Dec 18; Authors: Rothlind JC, York MK, Luo P, Carlson K, Marks WJ Jr, Weaver FM, Stern M, Follett KA, Duda JE, Reda DJ, CSP-468 study group.

• Reply to: "Age-Adjusted Serum Neurofilament Predicts Cognitive Decline in Parkinson's Disease (MARK-PD)".
  Movement disorders : official journal of the Movement Disorder Society. 2022 Feb;37(2):436-437; Authors: Aamodt WW, Chen-Plotkin AS

• Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study.
  Journal of affective disorders. 2022 Feb 1;298(Pt B):57-67 Epub 2021 Nov 17; Authors: Germine LT, Joormann J, Passell E, Rutter LA, Scheuer L, Martini P, Hwang I, Lee S, Sampson N, Barch DM, House SL, Beaudoin FL, An X, Stevens JS, Zeng D, Linnstaedt SD, Jovanovic T, Clifford GD, Neylan TC, Rauch SL, Lewandowski C, Hendry PL, Sheikh S, Storrow AB, Musey PI, Jones CW, Punches BE, McGrath ME, Pascual JL, Mohiuddin K, Pearson C, Peak DA, Domeier RM, Bruce SE, Rathlev NK, Sanchez LD, Pietrzak RH, Pizzagalli DA, Harte SE, Elliott JM, Koenen KC, Ressler KJ, McLean SA, Kessler RC

• Mis-splicing in Huntington's disease: harnessing the power of comparative transcriptomics.
  Trends in neurosciences. 2022 Feb;45(2):91-93 Epub 2021 Nov 6; Authors: Xing Y, Wang R, Davidson BL

• Multi-task learning based structured sparse canonical correlation analysis for brain imaging genetics.
  Medical image analysis. 2022 Feb;76:102297 Epub 2021 Nov 13; Authors: Kim M, Min EJ, Liu K, Yan J, Saykin AJ, Moore JH, Long Q, Shen L

• Embracing the disharmony in medical imaging: A Simple and effective framework for domain adaptation.
  Medical image analysis. 2022 Feb;76:102309 Epub 2021 Nov 26; Authors: Wang R, Chaudhari P, Davatzikos C

• Preparing for the age of therapeutic trials in frontotemporal lobar degeneration.
  Journal of neurology, neurosurgery, and psychiatry. 2022 Feb;93(2):115 Epub 2021 Aug 18; Authors: Irwin D

• Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium.
  Frontiers in neurology. 2021;12:805135 Epub 2022 Jan 31; Authors: Scott GD, Arnold MR, Beach TG, Gibbons CH, Kanthasamy AG, Lebovitz RM, Lemstra AW, Shaw LM, Teunissen CE, Zetterberg H, Taylor AS, Graham TC, Boeve BF, Gomperts SN, Graff-Radford NR, Moussa C, Poston KL, Rosenthal LS, Sabbagh MN, Walsh RR, Weber MT, Armstrong MJ, Bang JA, Bozoki AC, Domoto-Reilly K, Duda JE, Fleisher JE, Galasko DR, Galvin JE, Goldman JG, Holden SK, Honig LS, Huddleston DE, Leverenz JB, Litvan I, Manning CA, Marder KS, Pantelyat AY, Pelak VS, Scharre DW, Sha SJ, Shill HA, Mari Z, Quinn JF, Irwin DJ

• Genome-Wide association study of quantitative biomarkers identifies a novel locus for alzheimer's disease at 12p12.1.
  BMC genomics. 2022 Jan 28;23(1):85; Authors: Lee B, Yao X, Shen L, Alzheimer’s Disease Neuroimaging Initiative.

• Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia.
  Schizophrenia bulletin. 2022 Jan 21;48(1):199-210; Authors: Abi-Dargham A, Javitch JA, Slifstein M, Anticevic A, Calkins ME, Cho YT, Fonteneau C, Gil R, Girgis R, Gur RE, Gur RC, Grinband J, Kantrowitz J, Kohler C, Krystal J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Wolf D, TRANSCENDS Group., Gray D, Lieberman J

• Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries.
  Circulation research. 2022 Jan 21;130(2):166-180 Epub 2021 Dec 10; Authors: Škorić-Milosavljević D, Tadros R, Bosada FM, Tessadori F, van Weerd JH, Woudstra OI, Tjong FVY, Lahrouchi N, Bajolle F, Cordell HJ, Agopian AJ, Blue GM, Barge-Schaapveld DQCM, Gewillig M, Preuss C, Lodder EM, Barnett P, Ilgun A, Beekman L, van Duijvenboden K, Bokenkamp R, Müller-Nurasyid M, KORA-Study Group., Vliegen HW, Konings TC, van Melle JP, van Dijk APJ, van Kimmenade RRJ, Roos-Hesselink JW, Sieswerda GT, Meijboom F, Abdul-Khaliq H, Berger F, Dittrich S, Hitz MP, Moosmann J, Riede FT, Schubert S, Galan P, Lathrop M, Munter HM, Al-Chalabi A, Shaw CE, Shaw PJ, Morrison KE, Veldink JH, van den Berg LH, Evans S, Nobrega MA, Aneas I, Radivojkov-Blagojević M, Meitinger T, Oechslin E, Mondal T, Bergin L, Smythe JF, Altamirano-Diaz L, Lougheed J, Bouma BJ, Chaix MA, Kline J, Bassett AS, Andelfinger G, van der Palen RLF, Bouvagnet P, Clur SB, Breckpot J, Kerstjens-Frederikse WS, Winlaw DS, Bauer UMM, Mital S, Goldmuntz E, Keavney B, Bonnet D, Mulder BJ, Tanck MWT, Bakkers J, Christoffels VM, Boogerd CJ, Postma AV, Bezzina CR

• Functional brain activity constrained by structural connectivity reveals cohort-specific features for serum neurofilament light chain.
  Communications medicine. 2022;2:8 Epub 2022 Jan 17; Authors: Sihag S, Naze S, Taghdiri F, Gumus M, Tator C, Green R, Colella B, Blennow K, Zetterberg H, Dominguez LG, Wennberg R, Mikulis DJ, Tartaglia MC, Kozloski JR

• Nuclear-Import Receptors Counter Deleterious Phase Transitions in Neurodegenerative Disease.
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• Primary prevention recommendations to reduce the risk of cognitive decline.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Jan 13; Authors: Sabbagh MN, Perez A, Holland TM, Boustani M, Peabody SR, Yaffe K, Bruno M, Paulsen R, O'Brien K, Wahid N, Tanzi RE

• Predictors of interindividual differences in vulnerability to neurobehavioral consequences of chronic partial sleep restriction.
  Sleep. 2022 Jan 11;45(1); Authors: Galli O, Jones CW, Larson O, Basner M, Dinges DF

• Association of Antihypertensives That Stimulate vs Inhibit Types 2 and 4 Angiotensin II Receptors With Cognitive Impairment.
  JAMA network open. 2022 Jan 4;5(1):e2145319; Authors: Marcum ZA, Cohen JB, Zhang C, Derington CG, Greene TH, Ghazi L, Herrick JS, King JB, Cheung AK, Bryan N, Supiano MA, Sonnen JA, Weintraub WS, Williamson J, Pajewski NM, Bress AP, Systolic Blood Pressure Intervention Trial (SPRINT) Research Group.

• An Exploration of Subgroups of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Their Risks of Conversion to Dementia or Death.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2022 Jan 3; Authors: Qiu J, Goldstein FC, Hanfelt JJ

• Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells.
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• Alzheimer's Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer's Disease.
  Journal of Alzheimer's disease : JAD. 2022;86(1):461-477; Authors: Kuksa PP, Liu CL, Fu W, Qu L, Zhao Y, Katanic Z, Clark K, Kuzma AB, Ho PC, Tzeng KT, Valladares O, Chou SY, Naj AC, Schellenberg GD, Wang LS, Leung YY

• Sex Differences in the Metabolome of Alzheimer's Disease Progression.
  Frontiers in radiology. 2022;2 Epub 2022 Mar 14; Authors: Zarzar TG, Lee B, Coughlin R, Kim D, Shen L, Hall MA

• Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology.
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• Identifying highly heritable brain amyloid phenotypes through mining Alzheimer's imaging and sequencing biobank data.
  Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2022;27:109-120; Authors: Bao J, Wen Z, Kim M, Zhao X, Lee BN, Jung SH, Davatzikos C, Saykin AJ, Thompson PM, Kim D, Zhao Y, Shen L, Alzheimer’s Disease Neuroimaging Initiative.

• Associations of Peripheral Neuropathy Defined by Monofilament Insensitivity with Mild Cognitive Impairment and Dementia in Older Adults.
  Dementia and geriatric cognitive disorders. 2022;51(2):150-158 Epub 2022 Mar 28; Authors: Hicks CW, Wang D, Schneider ALC, Johansen MC, Gottesman RF, Matsushita K, Coresh J, Windham BG, Selvin E

• Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes.
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• Identifying imaging genetic associations via regional morphometricity estimation.
  Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2022;27:97-108; Authors: Bao J, Wen Z, Kim M, Saykin AJ, Thompson PM, Zhao Y, Shen L, Alzheimer’s Disease Neuroimaging Initiative.

• Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling.
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• Temporal Phenotypic Changes in Huntington's Disease Models for Preclinical Studies.
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• Informal Caregivers Provide Considerable Front-Line Support In Residential Care Facilities And Nursing Homes.
  Health affairs (Project Hope). 2022 Jan;41(1):105-111; Authors: Coe NB, Werner RM

• Geographic Barriers Drive Disparities in Specialty Center Access for Older Adults with Huntington's Disease.
  Journal of Huntington's disease. 2022;11(1):81-89; Authors: Pham Nguyen TP, Bravo L, Gonzalez-Alegre P, Willis AW

• The Role of Amyloid, Tau, and APOE Genotype on the Relationship Between Informant-Reported Sleep Disturbance and Alzheimer's Disease Risks.
  Journal of Alzheimer's disease : JAD. 2022;87(4):1567-1580; Authors: Kim H, Levine A, Cohen D, Gehrman P, Zhu X, Devanand DP, Lee S, Goldberg TE, Alzheimer’s Disease Neuroimaging Initiative.

• Effects of chronic intranasal dantrolene on nasal mucosa morphology in mice.
  European review for medical and pharmacological sciences. 2022 Jan;26(1):198-203; Authors: Jiang B, Shi Y, Abou MB, Xu L, Liang G, Wei H

• Neuropathological substrates of cognition in Parkinson's disease.
  Progress in brain research. 2022;269(1):177-193 Epub 2022 Feb 11; Authors: Coughlin DG, Irwin DJ

• Diagnosing Mild Cognitive Impairment Among Racially Diverse Older Adults: Comparison of Consensus, Actuarial, and Statistical Methods.
  Journal of Alzheimer's disease : JAD. 2022;85(2):627-644; Authors: Devlin KN, Brennan L, Saad L, Giovannetti T, Hamilton RH, Wolk DA, Xie SX, Mechanic-Hamilton D

• Appropriateness of Applying Cerebrospinal Fluid Biomarker Cutoffs from Alzheimer's Disease to Parkinson's Disease.
  Journal of Parkinson's disease. 2022;12(4):1155-1167; Authors: Weinshel S, Irwin DJ, Zhang P, Weintraub D, Shaw LM, Siderowf A, Xie SX

• Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease.
  Acta neuropathologica. 2022 Jan;143(1):15-31 Epub 2021 Dec 2; Authors: Uemura MT, Robinson JL, Cousins KAQ, Tropea TF, Kargilis DC, McBride JD, Suh E, Xie SX, Xu Y, Porta S, Uemura N, Van Deerlin VM, Wolk DA, Irwin DJ, Brunden KR, Lee VM, Lee EB, Trojanowski JQ

• The relative contributions of biomarkers, disease modifying treatment, and dementia severity to Alzheimer's stigma: A vignette-based experiment.
  Social science & medicine (1982). 2022 Jan;292:114620 Epub 2021 Dec 1; Authors: Stites SD, Gill J, Largent EA, Harkins K, Sankar P, Krieger A, Karlawish J

• Greater male than female variability in regional brain structure across the lifespan.
  Human brain mapping. 2022 Jan;43(1):470-499 Epub 2020 Oct 12; Authors: Wierenga LM, Doucet GE, Dima D, Agartz I, Aghajani M, Akudjedu TN, Albajes-Eizagirre A, Alnaes D, Alpert KI, Andreassen OA, Anticevic A, Asherson P, Banaschewski T, Bargallo N, Baumeister S, Baur-Streubel R, Bertolino A, Bonvino A, Boomsma DI, Borgwardt S, Bourque J, den Braber A, Brandeis D, Breier A, Brodaty H, Brouwer RM, Buitelaar JK, Busatto GF, Calhoun VD, Canales-Rodríguez EJ, Cannon DM, Caseras X, Castellanos FX, Chaim-Avancini TM, Ching CR, Clark VP, Conrod PJ, Conzelmann A, Crivello F, Davey CG, Dickie EW, Ehrlich S, Van't Ent D, Fisher SE, Fouche JP, Franke B, Fuentes-Claramonte P, de Geus EJ, Di Giorgio A, Glahn DC, Gotlib IH, Grabe HJ, Gruber O, Gruner P, Gur RE, Gur RC, Gurholt TP, de Haan L, Haatveit B, Harrison BJ, Hartman CA, Hatton SN, Heslenfeld DJ, van den Heuvel OA, Hickie IB, Hoekstra PJ, Hohmann S, Holmes AJ, Hoogman M, Hosten N, Howells FM, Hulshoff Pol HE, Huyser C, Jahanshad N, James AC, Jiang J, Jönsson EG, Joska JA, Kalnin AJ, Karolinska Schizophrenia Project (KaSP) Consortium., Klein M, Koenders L, Kolskår KK, Krämer B, Kuntsi J, Lagopoulos J, Lazaro L, Lebedeva IS, Lee PH, Lochner C, Machielsen MW, Maingault S, Martin NG, Martínez-Zalacaín I, Mataix-Cols D, Mazoyer B, McDonald BC, McDonald C, McIntosh AM, McMahon KL, McPhilemy G, van der Meer D, Menchón JM, Naaijen J, Nyberg L, Oosterlaan J, Paloyelis Y, Pauli P, Pergola G, Pomarol-Clotet E, Portella MJ, Radua J, Reif A, Richard G, Roffman JL, Rosa PG, Sacchet MD, Sachdev PS, Salvador R, Sarró S, Satterthwaite TD, Saykin AJ, Serpa MH, Sim K, Simmons A, Smoller JW, Sommer IE, Soriano-Mas C, Stein DJ, Strike LT, Szeszko PR, Temmingh HS, Thomopoulos SI, Tomyshev AS, Trollor JN, Uhlmann A, Veer IM, Veltman DJ, Voineskos A, Völzke H, Walter H, Wang L, Wang Y, Weber B, Wen W, West JD, Westlye LT, Whalley HC, Williams SC, Wittfeld K, Wolf DH, Wright MJ, Yoncheva YN, Zanetti MV, Ziegler GC, de Zubicaray GI, Thompson PM, Crone EA, Frangou S, Tamnes CK

• Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease.
  Neurobiology of aging. 2022 Jan;109:31-42 Epub 2021 Sep 6; Authors: Charissé D, Erus G, Pomponio R, Gorges M, Schmidt N, Schneider C, Liepelt-Scarfone I, Riedel O, Reetz K, Schulz JB, Berg D, Storch A, Witt K, Dodel R, Kalbe E, Kassubek J, Hilker-Roggendorf R, Baudrexel S

• A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.
  Human brain mapping. 2022 Jan;43(1):352-372 Epub 2021 Sep 8; Authors: Gutman BA, van Erp TGM, Alpert K, Ching CRK, Isaev D, Ragothaman A, Jahanshad N, Saremi A, Zavaliangos-Petropulu A, Glahn DC, Shen L, Cong S, Alnaes D, Andreassen OA, Doan NT, Westlye LT, Kochunov P, Satterthwaite TD, Wolf DH, Huang AJ, Kessler C, Weideman A, Nguyen D, Mueller BA, Faziola L, Potkin SG, Preda A, Mathalon DH, Bustillo J, Calhoun V, Ford JM, Walton E, Ehrlich S, Ducci G, Banaj N, Piras F, Piras F, Spalletta G, Canales-Rodríguez EJ, Fuentes-Claramonte P, Pomarol-Clotet E, Radua J, Salvador R, Sarró S, Dickie EW, Voineskos A, Tordesillas-Gutiérrez D, Crespo-Facorro B, Setién-Suero E, van Son JM, Borgwardt S, Schönborn-Harrisberger F, Morris D, Donohoe G, Holleran L, Cannon D, McDonald C, Corvin A, Gill M, Filho GB, Rosa PGP, Serpa MH, Zanetti MV, Lebedeva I, Kaleda V, Tomyshev A, Crow T, James A, Cervenka S, Sellgren CM, Fatouros-Bergman H, Agartz I, Howells F, Stein DJ, Temmingh H, Uhlmann A, de Zubicaray GI, McMahon KL, Wright M, Cobia D, Csernansky JG, Thompson PM, Turner JA, Wang L

• State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Jan;18(1):159-177 Epub 2021 May 27; Authors: Hampel H, Shaw LM, Aisen P, Chen C, Lleó A, Iwatsubo T, Iwata A, Yamada M, Ikeuchi T, Jia J, Wang H, Teunissen CE, Peskind E, Blennow K, Cummings J, Vergallo A

• Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.
  Human brain mapping. 2022 Jan;43(1):431-451 Epub 2021 Feb 17; Authors: Frangou S, Modabbernia A, Williams SCR, Papachristou E, Doucet GE, Agartz I, Aghajani M, Akudjedu TN, Albajes-Eizagirre A, Alnaes D, Alpert KI, Andersson M, Andreasen NC, Andreassen OA, Asherson P, Banaschewski T, Bargallo N, Baumeister S, Baur-Streubel R, Bertolino A, Bonvino A, Boomsma DI, Borgwardt S, Bourque J, Brandeis D, Breier A, Brodaty H, Brouwer RM, Buitelaar JK, Busatto GF, Buckner RL, Calhoun V, Canales-Rodríguez EJ, Cannon DM, Caseras X, Castellanos FX, Cervenka S, Chaim-Avancini TM, Ching CRK, Chubar V, Clark VP, Conrod P, Conzelmann A, Crespo-Facorro B, Crivello F, Crone EA, Dale AM, Dannlowski U, Davey C, de Geus EJC, de Haan L, de Zubicaray GI, den Braber A, Dickie EW, Di Giorgio A, Doan NT, Dørum ES, Ehrlich S, Erk S, Espeseth T, Fatouros-Bergman H, Fisher SE, Fouche JP, Franke B, Frodl T, Fuentes-Claramonte P, Glahn DC, Gotlib IH, Grabe HJ, Grimm O, Groenewold NA, Grotegerd D, Gruber O, Gruner P, Gur RE, Gur RC, Hahn T, Harrison BJ, Hartman CA, Hatton SN, Heinz A, Heslenfeld DJ, Hibar DP, Hickie IB, Ho BC, Hoekstra PJ, Hohmann S, Holmes AJ, Hoogman M, Hosten N, Howells FM, Hulshoff Pol HE, Huyser C, Jahanshad N, James A, Jernigan TL, Jiang J, Jönsson EG, Joska JA, Kahn R, Kalnin A, Kanai R, Klein M, Klyushnik TP, Koenders L, Koops S, Krämer B, Kuntsi J, Lagopoulos J, Lázaro L, Lebedeva I, Lee WH, Lesch KP, Lochner C, Machielsen MWJ, Maingault S, Martin NG, Martínez-Zalacaín I, Mataix-Cols D, Mazoyer B, McDonald C, McDonald BC, McIntosh AM, McMahon KL, McPhilemy G, Meinert S, Menchón JM, Medland SE, Meyer-Lindenberg A, Naaijen J, Najt P, Nakao T, Nordvik JE, Nyberg L, Oosterlaan J, de la Foz VO, Paloyelis Y, Pauli P, Pergola G, Pomarol-Clotet E, Portella MJ, Potkin SG, Radua J, Reif A, Rinker DA, Roffman JL, Rosa PGP, Sacchet MD, Sachdev PS, Salvador R, Sánchez-Juan P, Sarró S, Satterthwaite TD, Saykin AJ, Serpa MH, Schmaal L, Schnell K, Schumann G, Sim K, Smoller JW, Sommer I, Soriano-Mas C, Stein DJ, Strike LT, Swagerman SC, Tamnes CK, Temmingh HS, Thomopoulos SI, Tomyshev AS, Tordesillas-Gutiérrez D, Trollor JN, Turner JA, Uhlmann A, van den Heuvel OA, van den Meer D, van der Wee NJA, van Haren NEM, van 't Ent D, van Erp TGM, Veer IM, Veltman DJ, Voineskos A, Völzke H, Walter H, Walton E, Wang L, Wang Y, Wassink TH, Weber B, Wen W, West JD, Westlye LT, Whalley H, Wierenga LM, Wittfeld K, Wolf DH, Worker A, Wright MJ, Yang K, Yoncheva Y, Zanetti MV, Ziegler GC, Karolinska Schizophrenia Project (KaSP)., Thompson PM, Dima D

• Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.
  Human brain mapping. 2022 Jan;43(1):452-469 Epub 2021 Feb 11; Authors: Dima D, Modabbernia A, Papachristou E, Doucet GE, Agartz I, Aghajani M, Akudjedu TN, Albajes-Eizagirre A, Alnaes D, Alpert KI, Andersson M, Andreasen NC, Andreassen OA, Asherson P, Banaschewski T, Bargallo N, Baumeister S, Baur-Streubel R, Bertolino A, Bonvino A, Boomsma DI, Borgwardt S, Bourque J, Brandeis D, Breier A, Brodaty H, Brouwer RM, Buitelaar JK, Busatto GF, Buckner RL, Calhoun V, Canales-Rodríguez EJ, Cannon DM, Caseras X, Castellanos FX, Cervenka S, Chaim-Avancini TM, Ching CRK, Chubar V, Clark VP, Conrod P, Conzelmann A, Crespo-Facorro B, Crivello F, Crone EA, Dannlowski U, Dale AM, Davey C, de Geus EJC, de Haan L, de Zubicaray GI, den Braber A, Dickie EW, Di Giorgio A, Doan NT, Dørum ES, Ehrlich S, Erk S, Espeseth T, Fatouros-Bergman H, Fisher SE, Fouche JP, Franke B, Frodl T, Fuentes-Claramonte P, Glahn DC, Gotlib IH, Grabe HJ, Grimm O, Groenewold NA, Grotegerd D, Gruber O, Gruner P, Gur RE, Gur RC, Hahn T, Harrison BJ, Hartman CA, Hatton SN, Heinz A, Heslenfeld DJ, Hibar DP, Hickie IB, Ho BC, Hoekstra PJ, Hohmann S, Holmes AJ, Hoogman M, Hosten N, Howells FM, Hulshoff Pol HE, Huyser C, Jahanshad N, James A, Jernigan TL, Jiang J, Jönsson EG, Joska JA, Kahn R, Kalnin A, Kanai R, Klein M, Klyushnik TP, Koenders L, Koops S, Krämer B, Kuntsi J, Lagopoulos J, Lázaro L, Lebedeva I, Lee WH, Lesch KP, Lochner C, Machielsen MWJ, Maingault S, Martin NG, Martínez-Zalacaín I, Mataix-Cols D, Mazoyer B, McDonald C, McDonald BC, McIntosh AM, McMahon KL, McPhilemy G, Meinert S, Menchón JM, Medland SE, Meyer-Lindenberg A, Naaijen J, Najt P, Nakao T, Nordvik JE, Nyberg L, Oosterlaan J, de la Foz VO, Paloyelis Y, Pauli P, Pergola G, Pomarol-Clotet E, Portella MJ, Potkin SG, Radua J, Reif A, Rinker DA, Roffman JL, Rosa PGP, Sacchet MD, Sachdev PS, Salvador R, Sánchez-Juan P, Sarró S, Satterthwaite TD, Saykin AJ, Serpa MH, Schmaal L, Schnell K, Schumann G, Sim K, Smoller JW, Sommer I, Soriano-Mas C, Stein DJ, Strike LT, Swagerman SC, Tamnes CK, Temmingh HS, Thomopoulos SI, Tomyshev AS, Tordesillas-Gutiérrez D, Trollor JN, Turner JA, Uhlmann A, van den Heuvel OA, van den Meer D, van der Wee NJA, van Haren NEM, Van't Ent D, van Erp TGM, Veer IM, Veltman DJ, Voineskos A, Völzke H, Walter H, Walton E, Wang L, Wang Y, Wassink TH, Weber B, Wen W, West JD, Westlye LT, Whalley H, Wierenga LM, Williams SCR, Wittfeld K, Wolf DH, Worker A, Wright MJ, Yang K, Yoncheva Y, Zanetti MV, Ziegler GC, Thompson PM, Frangou S, Karolinska Schizophrenia Project (KaSP).

• Genome-wide association study and functional validation implicates JADE1 in tauopathy.
  Acta neuropathologica. 2022 Jan;143(1):33-53 Epub 2021 Nov 1; Authors: Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF

• Outcome Measures for Dementia With Lewy Body Clinical Trials: A Review.
  Alzheimer disease and associated disorders. 2022 Jan-Mar 01;36(1):64-72; Authors: Patel B, Irwin DJ, Kaufer D, Boeve BF, Taylor A, Armstrong MJ

• Functional and Cognitive Decline Among Older Adults After High-risk Surgery.
  Annals of surgery. 2022 Jan 1;275(1):e132-e139; Authors: Suwanabol PA, Li Y, Abrahamse P, De Roo AC, Vu JV, Silveira MJ, Mody L, Dimick JB

• Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease.
  Alzheimer's & dementia (Amsterdam, Netherlands). 2021;13(1):e12255 Epub 2021 Dec 31; Authors: Xue D, Bush WS, Renton AE, Marcora EA, Bis JC, Kunkle BW, Alzheimer's Disease Sequencing Project., Boerwinkle E, DeStefano AL, Farrer L, Goate A, Mayeux R, Pericak-Vance M, Schellenberg G, Seshadri S, Wijsman E, Haines JL, Blue EE

• Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Dec 22; Authors: Delaby C, Teunissen CE, Blennow K, Alcolea D, Arisi I, Amar EB, Beaume A, Bedel A, Bellomo G, Bigot-Corbel E, Bjerke M, Blanc-Quintin MC, Boada M, Bousiges O, Chapman MD, DeMarco ML, D'Onofrio M, Dumurgier J, Dufour-Rainfray D, Engelborghs S, Esselmann H, Fogli A, Gabelle A, Galloni E, Gondolf C, Grandhomme F, Grau-Rivera O, Hart M, Ikeuchi T, Jeromin A, Kasuga K, Keshavan A, Khalil M, Körtvelyessy P, Kulczynska-Przybik A, Laplanche JL, Lewczuk P, Li QX, Lleó A, Malaplate C, Marquié M, Masters CL, Mroczko B, Nogueira L, Orellana A, Otto M, Oudart JB, Paquet C, Paoletti FP, Parnetti L, Perret-Liaudet A, Peoc'h K, Poesen K, Puig-Pijoan A, Quadrio I, Quillard-Muraine M, Rucheton B, Schraen S, Schott JM, Shaw LM, Suárez-Calvet M, Tsolaki M, Tumani H, Udeh-Momoh CT, Vaudran L, Verbeek MM, Verde F, Vermunt L, Vogelgsang J, Wiltfang J, Zetterberg H, Lehmann S

• Predicting life expectancy after geriatric hip fracture: A systematic review.
  PloS one. 2021;16(12):e0261279 Epub 2021 Dec 15; Authors: Lee A, Weintraub S, Xi IL, Ahn J, Bernstein J

• Convergence, preliminary findings and future directions across the four human connectome projects investigating mood and anxiety disorders.
  NeuroImage. 2021 Dec 15;245:118694 Epub 2021 Oct 31; Authors: Tozzi L, Anene ET, Gotlib IH, Wintermark M, Kerr AB, Wu H, Seok D, Narr KL, Sheline YI, Whitfield-Gabrieli S, Williams LM

• Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice.
  Neurology(R) neuroimmunology & neuroinflammation. 2022 Jan;9(1) Epub 2021 Dec 13; Authors: Radosevic M, Planagumà J, Mannara F, Mellado A, Aguilar E, Sabater L, Landa J, García-Serra A, Maudes E, Gasull X, Lewis M, Dalmau J

• Prevalence of Oropharyngeal Dysphagia and Risk of Pneumonia, Malnutrition, and Mortality in Adults Aged 60 Years and Older: A Meta-Analysis.
  Gerontology. 2021 Dec 13;:1-13; Authors: Banda KJ, Chu H, Chen R, Kang XL, Jen HJ, Liu D, Shen Hsiao ST, Chou KR

• Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.
  Translational psychiatry. 2021 Dec 6;11(1):618; Authors: Chen HH, Petty LE, Sha J, Zhao Y, Kuzma A, Valladares O, Alzheimer’s Disease Genetics Consortium, International Genomics of Alzheimer’s Project., Bush W, Naj AC, Gamazon ER, Below JE

• A deep learning framework identifies dimensional representations of Alzheimer's Disease from brain structure.
  Nature communications. 2021 Dec 3;12(1):7065; Authors: Yang Z, Nasrallah IM, Shou H, Wen J, Doshi J, Habes M, Erus G, Abdulkadir A, Resnick SM, Albert MS, Maruff P, Fripp J, Morris JC, Wolk DA, Davatzikos C, iSTAGING Consortium., Baltimore Longitudinal Study of Aging (BLSA)., Alzheimer’s Disease Neuroimaging Initiative (ADNI).

• The contribution of behavioral features to caregiver burden in FTLD spectrum disorders.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Dec 2; Authors: Silverman HE, Ake JM, Manoochehri M, Appleby BS, Brushaber D, Devick KL, Dickerson BC, Fields JA, Forsberg LK, Ghoshal N, Graff-Radford NR, Grossman M, Heuer HW, Kornak J, Lapid MI, Litvan I, Mackenzie IR, Mendez MF, Onyike CU, Pascual B, Tartaglia MC, Boeve BF, Boxer AL, Rosen HJ, Cosentino S, Huey ED, Barker MS, Goldman JS, ALLFTD consortium.

• Alzheimer's Disease-Related Dementias Summit 2019: National Research Priorities for the Investigation of Traumatic Brain Injury as a Risk Factor for Alzheimer's Disease and Related Dementias.
  Journal of neurotrauma. 2021 Dec;38(23):3186-3194; Authors: Dams-O'Connor K, Bellgowan PSF, Corriveau R, Pugh MJ, Smith DH, Schneider JA, Whitaker K, Zetterberg H

• FDA Drug Approval and the Ethics of Desperation.
  JAMA internal medicine. 2021 Dec 1;181(12):1555-1556; Authors: Largent EA, Peterson A, Lynch HF

• The ethical implications of paradoxical lucidity in persons with dementia.
  Journal of the American Geriatrics Society. 2021 Dec;69(12):3617-3622 Epub 2021 Oct 10; Authors: Ney DB, Peterson A, Karlawish J

• Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
  Nature genetics. 2021 Dec;53(12):1636-1648 Epub 2021 Dec 6; Authors: van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra HJ, Bakker OB, Deelen P, Shireby G, Hannon E, Moisse M, Baird D, Restuadi R, Dolzhenko E, Dekker AM, Gawor K, Westeneng HJ, Tazelaar GHP, van Eijk KR, Kooyman M, Byrne RP, Doherty M, Heverin M, Al Khleifat A, Iacoangeli A, Shatunov A, Ticozzi N, Cooper-Knock J, Smith BN, Gromicho M, Chandran S, Pal S, Morrison KE, Shaw PJ, Hardy J, Orrell RW, Sendtner M, Meyer T, Başak N, van der Kooi AJ, Ratti A, Fogh I, Gellera C, Lauria G, Corti S, Cereda C, Sproviero D, D'Alfonso S, Sorarù G, Siciliano G, Filosto M, Padovani A, Chiò A, Calvo A, Moglia C, Brunetti M, Canosa A, Grassano M, Beghi E, Pupillo E, Logroscino G, Nefussy B, Osmanovic A, Nordin A, Lerner Y, Zabari M, Gotkine M, Baloh RH, Bell S, Vourc'h P, Corcia P, Couratier P, Millecamps S, Meininger V, Salachas F, Mora Pardina JS, Assialioui A, Rojas-García R, Dion PA, Ross JP, Ludolph AC, Weishaupt JH, Brenner D, Freischmidt A, Bensimon G, Brice A, Durr A, Payan CAM, Saker-Delye S, Wood NW, Topp S, Rademakers R, Tittmann L, Lieb W, Franke A, Ripke S, Braun A, Kraft J, Whiteman DC, Olsen CM, Uitterlinden AG, Hofman A, Rietschel M, Cichon S, Nöthen MM, Amouyel P, SLALOM Consortium., PARALS Consortium., SLAGEN Consortium., SLAP Consortium., Traynor BJ, Singleton AB, Mitne Neto M, Cauchi RJ, Ophoff RA, Wiedau-Pazos M, Lomen-Hoerth C, van Deerlin VM, Grosskreutz J, Roediger A, Gaur N, Jörk A, Barthel T, Theele E, Ilse B, Stubendorff B, Witte OW, Steinbach R, Hübner CA, Graff C, Brylev L, Fominykh V, Demeshonok V, Ataulina A, Rogelj B, Koritnik B, Zidar J, Ravnik-Glavač M, Glavač D, Stević Z, Drory V, Povedano M, Blair IP, Kiernan MC, Benyamin B, Henderson RD, Furlong S, Mathers S, McCombe PA, Needham M, Ngo ST, Nicholson GA, Pamphlett R, Rowe DB, Steyn FJ, Williams KL, Mather KA, Sachdev PS, Henders AK, Wallace L, de Carvalho M, Pinto S, Petri S, Weber M, Rouleau GA, Silani V, Curtis CJ, Breen G, Glass JD, Brown RH Jr, Landers JE, Shaw CE, Andersen PM, Groen EJN, van Es MA, Pasterkamp RJ, Fan D, Garton FC, McRae AF, Davey Smith G, Gaunt TR, Eberle MA, Mill J, McLaughlin RL, Hardiman O, Kenna KP, Wray NR, Tsai E, Runz H, Franke L, Al-Chalabi A, Van Damme P, van den Berg LH, Veldink JH

• N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate.
  The Journal of biological chemistry. 2021 Dec;297(6):101363 Epub 2021 Oct 31; Authors: Gottlieb L, Guo L, Shorter J, Marmorstein R

• The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Dec;17(12):2043-2055 Epub 2021 May 21; Authors: Apostolova LG, Aisen P, Eloyan A, Fagan A, Fargo KN, Foroud T, Gatsonis C, Grinberg LT, Jack CR Jr, Kramer J, Koeppe R, Kukull WA, Murray ME, Nudelman K, Rumbaugh M, Toga A, Vemuri P, Trullinger A, Iaccarino L, Day GS, Graff-Radford NR, Honig LS, Jones DT, Masdeu J, Mendez M, Musiek E, Onyike CU, Rogalski E, Salloway S, Wolk DA, Wingo TS, Carrillo MC, Dickerson BC, Rabinovici GD, LEADS Consortium.

• AD-linked R47H-<i>TREM2</i> mutation induces disease-enhancing microglial states via AKT hyperactivation.
  Science translational medicine. 2021 Dec;13(622):eabe3947 Epub 2021 Dec 1; Authors: Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MY, Horowitz R, Ye P, Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Gao F, Brendel M, Telpoukhovskaia M, Tracy TE, Frost G, Zhou Y, Li Y, Qiu Y, Cheng Z, Yu G, Hardy J, Coppola G, Wang F, DeTure MA, Zhang B, Xie L, Trajnowski JQ, Lee VMY, Gong S, Sinha SC, Dickson DW, Luo W, Gan L

• Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease.
  Journal of neurology, neurosurgery, and psychiatry. 2021 Dec;92(12):1313-1318 Epub 2021 Sep 11; Authors: Sauerbier A, Loehrer P, Jost ST, Heil S, Petry-Schmelzer JN, Herberg J, Bachon P, Aloui S, Gronostay A, Klingelhoefer L, Baldermann JC, Huys D, Nimsky C, Barbe MT, Fink GR, Martinez-Martin P, Ray Chaudhuri K, Visser-Vandewalle V, Timmermann L, Weintraub D, Dafsari HS, EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson's Disease Study Group.

• The Current State of Pharma and the FDA: Approval of a Dementia Drug as a Case in Point.
  The American journal of medicine. 2021 Dec;134(12):1442-1443 Epub 2021 Jul 12; Authors: Eiser AR

• Functional Outcomes, Goals, and Goal Attainment among Chronically Critically Ill Long-Term Acute Care Hospital Patients.
  Annals of the American Thoracic Society. 2021 Dec;18(12):2041-2048; Authors: Dubin R, Veith JM, Grippi MA, McPeake J, Harhay MO, Mikkelsen ME

• Common genetic variation is associated with longitudinal decline and network features in behavioral variant frontotemporal degeneration.
  Neurobiology of aging. 2021 Dec;108:16-23 Epub 2021 Aug 3; Authors: Massimo L, Rennert L, Xie SX, Olm C, Bove J, Van Deerlin V, Irwin DJ, Grossman M, McMillan CT

• Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.
  British journal of anaesthesia. 2021 Dec;127(6):917-928 Epub 2021 Sep 14; Authors: Browndyke JN, Wright MC, Yang R, Syed A, Park J, Hall A, Martucci K, Devinney MJ, Shaw L, Waligorska T, Moretti EW, Whitson HE, Cohen HJ, Mathew JP, Berger M, MADCO-PC Investigators.

• Does it Matter Who Decides? Outcomes of Surrogate Decision-Making for Community-Dwelling, Cognitively Impaired Older Adults Near the End of Life.
  Journal of pain and symptom management. 2021 Dec;62(6):1126-1134 Epub 2021 Jun 19; Authors: Baum MY, Gallo JJ, Nolan MT, Langa KM, Halpern SD, Macis M, Nicholas LH

• Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Dec;17(12):1976-1987 Epub 2021 May 13; Authors: Libiger O, Shaw LM, Watson MH, Nairn AC, Umaña KL, Biarnes MC, Canet-Avilés RM, Jack CR Jr, Breton YA, Cortes L, Chelsky D, Spellman DS, Baker SA, Raghavan N, Potter WZ, Alzheimer's Disease Neuroimaging Initiative (ADNI)., Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium, Longitudinal CSF Proteomics Project Team.

• Interpretable temporal graph neural network for prognostic prediction of Alzheimer's disease using longitudinal neuroimaging data.
  Proceedings. IEEE International Conference on Bioinformatics and Biomedicine. 2021 Dec;2021:1381-1384; Authors: Kim M, Kim J, Qu J, Huang H, Long Q, Sohn KA, Kim D, Shen L

• Distinct brain-derived TDP-43 strains from FTLD-TDP subtypes induce diverse morphological TDP-43 aggregates and spreading patterns in vitro and in vivo.
  Neuropathology and applied neurobiology. 2021 Dec;47(7):1033-1049 Epub 2021 May 21; Authors: Porta S, Xu Y, Lehr T, Zhang B, Meymand E, Olufemi M, Stieber A, Lee EB, Trojanowski JQ, Lee VM

• Utilization and Cost Effects of the VHA Caring for Older Adults and Caregivers at Home (COACH) Program.
  Medical care research and review : MCRR. 2021 Dec;78(6):736-746 Epub 2020 Jul 9; Authors: Song W, Intrator O, Twersky J, Davagnino J, Kinosian B, Wieland D

• Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease.
  Movement disorders : official journal of the Movement Disorder Society. 2021 Dec;36(12):2945-2950 Epub 2021 Sep 4; Authors: Aamodt WW, Waligorska T, Shen J, Tropea TF, Siderowf A, Weintraub D, Grossman M, Irwin D, Wolk DA, Xie SX, Trojanowski JQ, Shaw LM, Chen-Plotkin AS

• An Update on the State of Tau Radiotracer Development: a Brief Review.
  Molecular imaging and biology. 2021 Dec;23(6):797-808 Epub 2021 May 13; Authors: Rigney G, Ayubcha C, Werner TJ, Alavi A

• Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics.
  Human molecular genetics. 2021 Nov 30;30(24):2469-2487; Authors: Akimov SS, Jiang M, Kedaigle AJ, Arbez N, Marque LO, Eddings CR, Ranum PT, Whelan E, Tang A, Wang R, DeVine LR, Talbot CC, Cole RN, Ratovitski T, Davidson BL, Fraenkel E, Ross CA

• Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Nov 29; Authors: Verberk IMW, Misdorp EO, Koelewijn J, Ball AJ, Blennow K, Dage JL, Fandos N, Hansson O, Hirtz C, Janelidze S, Kang S, Kirmess K, Kindermans J, Lee R, Meyer MR, Shan D, Shaw LM, Waligorska T, West T, Zetterberg H, Edelmayer RM, Teunissen CE

• Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau.
  Acta neuropathologica communications. 2021 Nov 18;9(1):184; Authors: Kim BJ, Lee V, Lee EB, Saludades A, Trojanowski JQ, Dunaief JL, Grossman M, Irwin DJ

• Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function.
  International journal of ophthalmology. 2021;14(11):1721-1728 Epub 2021 Nov 18; Authors: Cui QN, Green D, Jethi M, Driver T, Porco TC, Kuo J, Lin SC, Stamper RL, Han Y, Chiu CS, Ramanathan S, Ward ME, Possin K, Ou Y

• Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT).
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Nov 17; Authors: Pajewski NM, Elahi FM, Tamura MK, Hinman JD, Nasrallah IM, Ix JH, Miller LM, Launer LJ, Wright CB, Supiano MA, Lerner AJ, Sudduth TL, Killeen AA, Cheung AK, Reboussin DM, Wilcock DM, Williamson JD

• Hippocampal and rostral anterior cingulate blood flow is associated with affective symptoms in chronic traumatic brain injury.
  Brain research. 2021 Nov 15;1771:147631 Epub 2021 Aug 28; Authors: Thomas BP, Tarumi T, Wang C, Zhu DC, Tomoto T, Munro Cullum C, Dieppa M, Diaz-Arrastia R, Bell K, Madden C, Zhang R, Ding K

• The Effect of Oxidative Stress and Memantine-Incorporated Reactive Oxygen Species-Sensitive Nanoparticles on the Expression of <i>N</i>-Methyl-d-aspartate Receptor Subunit 1 in Brain Cancer Cells for Alzheimer's Disease Application.
  International journal of molecular sciences. 2021 Nov 15;22(22); Authors: Park JS, Kim T, Kim D, Jeong YI

• Neural Mechanisms Underlying Breast Cancer Related Fatigue: A Systematic Review of Neuroimaging Studies.
  Frontiers in neuroscience. 2021;15:735945 Epub 2021 Nov 10; Authors: Arya N, Vaish A, Zhao K, Rao H

• IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes.
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• Psychometric Properties of Rapid Word-Based Rate Measures in the Assessment of Bulbar Amyotrophic Lateral Sclerosis: Comparisons With Syllable-Based Rate Tasks.
  Journal of speech, language, and hearing research : JSLHR. 2021 Nov 8;64(11):4178-4191 Epub 2021 Oct 26; Authors: Shellikeri S, Marzouqah R, Brooks BR, Zinman L, Green JR, Yunusova Y

• TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.
  Science advances. 2021 Nov 5;7(45):eabg3897; Authors: Alquezar C, Schoch KM, Geier EG, Ramos EM, Scrivo A, Li KH, Argouarch AR, Mlynarski EE, Dombroski B, DeTure M, Dickson DW, Yokoyama JS, Cuervo AM, Burlingame AL, Schellenberg GD, Miller TM, Miller BL, Kao AW

• Copy Number Variation Identification on 3,800 Alzheimer's Disease Whole Genome Sequencing Data from the Alzheimer's Disease Sequencing Project.
  Frontiers in genetics. 2021;12:752390 Epub 2021 Nov 4; Authors: Lee WP, Tucci AA, Conery M, Leung YY, Kuzma AB, Valladares O, Chou YF, Lu W, Wang LS, Schellenberg GD, Tzeng JY

• Neuropathological Variability within a Spectrum of NMDAR-Encephalitis.
  Annals of neurology. 2021 Nov;90(5):725-737 Epub 2021 Oct 9; Authors: Zrzavy T, Endmayr V, Bauer J, Macher S, Mossaheb N, Schwaiger C, Ricken G, Winklehner M, Glatter S, Breu M, Wimmer I, Kovacs GG, Risser DU, Klupp N, Simonitsch-Klupp I, Roetzer T, Rommer P, Berger T, Gelpi E, Lassmann H, Graus F, Dalmau J, Höftberger R

• Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis.
  JAMA internal medicine. 2021 Nov 1;181(11):1440-1450; Authors: van Vliet NA, van Heemst D, Almeida OP, Åsvold BO, Aubert CE, Bae JB, Barnes LE, Bauer DC, Blauw GJ, Brayne C, Cappola AR, Ceresini G, Comijs HC, Dartigues JF, Degryse JM, Dullaart RPF, van Eersel MEA, den Elzen WPJ, Ferrucci L, Fink HA, Flicker L, Grabe HJ, Han JW, Helmer C, Huisman M, Ikram MA, Imaizumi M, de Jongh RT, Jukema JW, Kim KW, Kuller LH, Lopez OL, Mooijaart SP, Moon JH, Moutzouri E, Nauck M, Parle J, Peeters RP, Samuels MH, Schmidt CO, Schminke U, Slagboom PE, Stordal E, Vaes B, Völzke H, Westendorp RGJ, Yamada M, Yeap BB, Rodondi N, Gussekloo J, Trompet S, Thyroid Studies Collaboration.

• Features of intracranial interictal epileptiform discharges associated with memory encoding.
  Epilepsia. 2021 Nov;62(11):2615-2626 Epub 2021 Sep 5; Authors: Quon RJ, Camp EJ, Meisenhelter S, Song Y, Steimel SA, Testorf ME, Andrew AS, Gross RE, Lega BC, Sperling MR, Kahana MJ, Jobst BC

• DeepAtrophy: Teaching a neural network to detect progressive changes in longitudinal MRI of the hippocampal region in Alzheimer's disease.
  NeuroImage. 2021 Nov;243:118514 Epub 2021 Aug 24; Authors: Dong M, Xie L, Das SR, Wang J, Wisse LEM, deFlores R, Wolk DA, Yushkevich PA, Alzheimer's Disease Neuroimaging Initiative.

• Neurocognitive predictors of treatment outcomes in psychotherapy for comorbid PTSD and substance use disorders.
  Journal of consulting and clinical psychology. 2021 Nov;89(11):937-946; Authors: Scott JC, Lynch KG, Cenkner DP, Kehle-Forbes SM, Polusny MA, Gur RC, Chen S, Foa EB, Oslin DW

• Diagnostic accuracy of blood biomarkers for Alzheimer's disease and amnestic mild cognitive impairment: A meta-analysis.
  Ageing research reviews. 2021 Nov;71:101446 Epub 2021 Aug 12; Authors: Chen YR, Liang CS, Chu H, Voss J, Kang XL, O'Connell G, Jen HJ, Liu D, Shen Hsiao ST, Chou KR

• Predictive value of ATN biomarker profiles in estimating disease progression in Alzheimer's disease dementia.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Nov;17(11):1855-1867 Epub 2021 Nov 10; Authors: Ezzati A, Abdulkadir A, Jack CR Jr, Thompson PM, Harvey DJ, Truelove-Hill M, Sreepada LP, Davatzikos C, Alzheimer's Disease Neuroimaging Initiative., Lipton RB

• Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology.
  Nuclear medicine communications. 2021 Nov 1;42(11):1261-1269; Authors: Duong MT, Chen YJ, Doot RK, Young AJ, Lee H, Cai J, Pilania A, Wolk DA, Nasrallah IM

• Family members' perspectives on learning cognitively unimpaired older adults' amyloid-β PET scan results.
  Journal of the American Geriatrics Society. 2021 Nov;69(11):3203-3211 Epub 2021 Jul 12; Authors: Largent EA, Abera M, Harkins K, Feldman SJ, Uhlmann WR, Roberts JS, Karlawish J, REVEAL-SCAN Team.

• Anesthetic Effects on the Progression of Parkinson Disease in the Rat DJ-1 Model.
  Anesthesia and analgesia. 2021 Nov 1;133(5):1140-1151; Authors: Xu DA, DeYoung TP, Kondoleon NP, Eckenhoff RG, Eckenhoff MF

• Aducanumab and the Business of Alzheimer Disease-Some Choice.
  JAMA neurology. 2021 Nov 1;78(11):1303-1304; Authors: Karlawish J

• Trends in Receipt of Help at Home After Hospital Discharge Among Older Adults in the US.
  JAMA network open. 2021 Nov 1;4(11):e2135346; Authors: Bressman E, Coe NB, Chen X, Konetzka RT, Werner RM

• Peripheral nerve block anesthesia/analgesia for patients undergoing primary hip and knee arthroplasty: recommendations from the International Consensus on Anesthesia-Related Outcomes after Surgery (ICAROS) group based on a systematic review and meta-analysis of current literature.
  Regional anesthesia and pain medicine. 2021 Nov;46(11):971-985 Epub 2021 Aug 25; Authors: Memtsoudis SG, Cozowicz C, Bekeris J, Bekere D, Liu J, Soffin EM, Mariano ER, Johnson RL, Go G, Hargett MJ, Lee BH, Wendel P, Brouillette M, Kim SJ, Baaklini L, Wetmore DS, Hong G, Goto R, Jivanelli B, Athanassoglou V, Argyra E, Barrington MJ, Borgeat A, De Andres J, El-Boghdadly K, Elkassabany NM, Gautier P, Gerner P, Gonzalez Della Valle A, Goytizolo E, Guo Z, Hogg R, Kehlet H, Kessler P, Kopp S, Lavand'homme P, Macfarlane A, MacLean C, Mantilla C, McIsaac D, McLawhorn A, Neal JM, Parks M, Parvizi J, Peng P, Pichler L, Poeran J, Poultsides L, Schwenk ES, Sites BD, Stundner O, Sun EC, Viscusi E, Votta-Velis EG, Wu CL, YaDeau J, Sharrock NE

• A vicious cycle of neuropathological, cognitive and behavioural sequelae of repeated opioid overdose.
  The International journal on drug policy. 2021 Nov;97:103362 Epub 2021 Jul 24; Authors: Voronkov M, Ataiants J, Cocchiaro B, Stock JB, Lankenau SE

• Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease.
  Annals of neurology. 2021 Nov;90(5):751-762 Epub 2021 Oct 15; Authors: Das SR, Lyu X, Duong MT, Xie L, McCollum L, de Flores R, DiCalogero M, Irwin DJ, Dickerson BC, Nasrallah IM, Yushkevich PA, Wolk DA, Alzheimer's Disease Neuroimaging Initiative.

• A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease.
  Circulation research. 2021 Oct 29;129(10):968-970 Epub 2021 Sep 22; Authors: Levin MG, Klarin D, Georgakis MK, Lynch J, Liao KP, Voight BF, O'Donnell CJ, Chang KM, Assimes TL, Tsao PS, Damrauer SM, VA Million Veteran Program.

• SLITRK2, an X-linked modifier of the age at onset in C9orf72 frontotemporal lobar degeneration.
  Brain : a journal of neurology. 2021 Oct 22;144(9):2798-2811; Authors: Barbier M, Camuzat A, Hachimi KE, Guegan J, Rinaldi D, Lattante S, Houot M, Sánchez-Valle R, Sabatelli M, Antonell A, Molina-Porcel L, Clot F, Couratier P, van der Ende E, van der Zee J, Manzoni C, Camu W, Cazeneuve C, Sellal F, Didic M, Golfier V, Pasquier F, Duyckaerts C, Rossi G, Bruni AC, Alvarez V, Gómez-Tortosa E, de Mendonça A, Graff C, Masellis M, Nacmias B, Oumoussa BM, Jornea L, Forlani S, French clinical and genetic Research network on FTLD/FTLD-ALS and PREVDEMALS, The International Frontotemporal Dementia Genomics Consortium, The European Early Onset Dementia (EU -EOD) Consortium, Brainbank Neuro-CEB Neuropathology Network, Neurological Tissue Bank of the Biobank Hospital Clinic-IDIBAPS., Van Deerlin V, Rohrer JD, Gelpi E, Rademakers R, Van Swieten J, Le Guern E, Van Broeckhoven C, Ferrari R, Génin E, Brice A, Le Ber I

• Early stages of tau pathology and its associations with functional connectivity, atrophy and memory.
  Brain : a journal of neurology. 2021 Oct 22;144(9):2771-2783; Authors: Berron D, Vogel JW, Insel PS, Pereira JB, Xie L, Wisse LEM, Yushkevich PA, Palmqvist S, Mattsson-Carlgren N, Stomrud E, Smith R, Strandberg O, Hansson O

• Methylphenidate modulates interactions of anxiety with cognition.
  Translational psychiatry. 2021 Oct 21;11(1):544; Authors: Gaillard C, Lago TR, Gorka AX, Balderston NL, Fuchs BA, Reynolds RC, Grillon C, Ernst M

• Effects of the tailored activity program (TAP) on dementia-related symptoms, health events and caregiver wellbeing: a randomized controlled trial.
  BMC geriatrics. 2021 Oct 20;21(1):581; Authors: Gitlin LN, Marx K, Piersol CV, Hodgson NA, Huang J, Roth DL, Lyketsos C

• Adaptation of the pediatric smell wheel to evaluate olfactory function in Brazilian children.
  Brazilian journal of otorhinolaryngology. 2021 Oct 17; Authors: Fornazieri MA, Ebara LK, Araújo RG, Lima JVF, Favareto FB, Pinna FR, Voegels RL, Doty RL

• Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation.
  The Journal of clinical investigation. 2021 Oct 15;131(20); Authors: Gaudette BT, Roman CJ, Ochoa TA, Gómez Atria D, Jones DD, Siebel CW, Maillard I, Allman D

• The global Alzheimer's Association round robin study on plasma amyloid β methods.
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• Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Oct 14; Authors: Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR Jr, Jagust WJ, Petersen RC, Saykin AJ, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative.

• Observational study of patient characteristics associated with a timely diagnosis of dementia and mild cognitive impairment without dementia.
  Journal of general internal medicine. 2021 Oct 13; Authors: White L, Ingraham B, Larson E, Fishman P, Park S, Coe NB

• A Middle Ground for Accelerated Drug Approval-Lessons From Aducanumab.
  JAMA. 2021 Oct 12;326(14):1367-1368; Authors: Emanuel EJ

• Cortical feedback and gating in odor discrimination and generalization.
  PLoS computational biology. 2021 Oct;17(10):e1009479 Epub 2021 Oct 11; Authors: Tavoni G, Kersen DEC, Balasubramanian V

• Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies.
  Biomolecules. 2021 Oct 8;11(10); Authors: Campo MD, Pijnenburg YAL, Chen-Plotkin A, Irwin DJ, Grossman M, Twaalfhoven HAM, Hu WT, Meeter LH, van Swieten J, Vermunt L, Martens F, Heijboer AC, Teunissen CE

• Antimuscarinic Anticholinergic Medications in Parkinson Disease: To Prescribe or Deprescribe?
  Movement disorders clinical practice. 2021 Nov;8(8):1181-1188 Epub 2021 Oct 8; Authors: Barrett MJ, Sargent L, Nawaz H, Weintraub D, Price ET, Willis AW

• Biomarkers of neurodegeneration and glial activation validated in Alzheimer's disease assessed in longitudinal cerebrospinal fluid samples of Parkinson's disease.
  PloS one. 2021;16(10):e0257372 Epub 2021 Oct 7; Authors: Bartl M, Dakna M, Galasko D, Hutten SJ, Foroud T, Quan M, Marek K, Siderowf A, Franz J, Trenkwalder C, Mollenhauer B, Parkinson’s Progression Markers Initiative.

• Cellular anatomy of the mouse primary motor cortex.
  Nature. 2021 Oct;598(7879):159-166 Epub 2021 Oct 6; Authors: Muñoz-Castañeda R, Zingg B, Matho KS, Chen X, Wang Q, Foster NN, Li A, Narasimhan A, Hirokawa KE, Huo B, Bannerjee S, Korobkova L, Park CS, Park YG, Bienkowski MS, Chon U, Wheeler DW, Li X, Wang Y, Naeemi M, Xie P, Liu L, Kelly K, An X, Attili SM, Bowman I, Bludova A, Cetin A, Ding L, Drewes R, D'Orazi F, Elowsky C, Fischer S, Galbavy W, Gao L, Gillis J, Groblewski PA, Gou L, Hahn JD, Hatfield JT, Hintiryan H, Huang JJ, Kondo H, Kuang X, Lesnar P, Li X, Li Y, Lin M, Lo D, Mizrachi J, Mok S, Nicovich PR, Palaniswamy R, Palmer J, Qi X, Shen E, Sun YC, Tao HW, Wakemen W, Wang Y, Yao S, Yuan J, Zhan H, Zhu M, Ng L, Zhang LI, Lim BK, Hawrylycz M, Gong H, Gee JC, Kim Y, Chung K, Yang XW, Peng H, Luo Q, Mitra PP, Zador AM, Zeng H, Ascoli GA, Josh Huang Z, Osten P, Harris JA, Dong HW

• Autophagy in major human diseases.
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• Cortical disconnection in temporal lobe epilepsy.
  Epilepsy & behavior : E&B. 2021 Oct;123:108231 Epub 2021 Aug 7; Authors: Gleichgerrcht E, Kellermann TS, Drane DL, Keller SS, McDonald CR, Rorden C, Jensen J, Weber B, Davis KA, Kuzniecky R, Bonilha L

• Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis.
  JAMA neurology. 2021 Oct 1;78(10):1236-1248; Authors: Johnson JO, Chia R, Miller DE, Li R, Kumaran R, Abramzon Y, Alahmady N, Renton AE, Topp SD, Gibbs JR, Cookson MR, Sabir MS, Dalgard CL, Troakes C, Jones AR, Shatunov A, Iacoangeli A, Al Khleifat A, Ticozzi N, Silani V, Gellera C, Blair IP, Dobson-Stone C, Kwok JB, Bonkowski ES, Palvadeau R, Tienari PJ, Morrison KE, Shaw PJ, Al-Chalabi A, Brown RH Jr, Calvo A, Mora G, Al-Saif H, Gotkine M, Leigh F, Chang IJ, Perlman SJ, Glass I, Scott AI, Shaw CE, Basak AN, Landers JE, Chiò A, Crawford TO, Smith BN, Traynor BJ, FALS Sequencing Consortium; American Genome Center; International ALS Genomics Consortium; and ITALSGEN Consortium., Smith BN, Ticozzi N, Fallini C, Gkazi AS, Topp SD, Scotter EL, Kenna KP, Keagle P, Tiloca C, Vance C, Troakes C, Colombrita C, King A, Pensato V, Castellotti B, Baas F, Ten Asbroek ALMA, McKenna-Yasek D, McLaughlin RL, Polak M, Asress S, Esteban-Pérez J, Stevic Z, D'Alfonso S, Mazzini L, Comi GP, Del Bo R, Ceroni M, Gagliardi S, Querin G, Bertolin C, van Rheenen W, Rademakers R, van Blitterswijk M, Lauria G, Duga S, Corti S, Cereda C, Corrado L, Sorarù G, Williams KL, Nicholson GA, Blair IP, Leblond-Manry C, Rouleau GA, Hardiman O, Morrison KE, Veldink JH, van den Berg LH, Al-Chalabi A, Pall H, Shaw PJ, Turner MR, Talbot K, Taroni F, García-Redondo A, Wu Z, Glass JD, Gellera C, Ratti A, Brown RH Jr, Silani V, Shaw CE, Landers JE, Dalgard CL, Adeleye A, Soltis AR, Alba C, Viollet C, Bacikova D, Hupalo DN, Sukumar G, Pollard HB, Wilkerson MD, Martinez EM, Abramzon Y, Ahmed S, Arepalli S, Baloh RH, Bowser R, Brady CB, Brice A, Broach J, Campbell RH, Camu W, Chia R, Cooper-Knock J, Ding J, Drepper C, Drory VE, Dunckley TL, Eicher JD, England BK, Faghri F, Feldman E, Floeter MK, Fratta P, Geiger JT, Gerhard G, Gibbs JR, Gibson SB, Glass JD, Hardy J, Harms MB, Heiman-Patterson TD, Hernandez DG, Jansson L, Kirby J, Kowall NW, Laaksovirta H, Landeck N, Landi F, Le Ber I, Lumbroso S, MacGowan DJL, Maragakis NJ, Mora G, Mouzat K, Murphy NA, Myllykangas L, Nalls MA, Orrell RW, Ostrow LW, Pamphlett R, Pickering-Brown S, Pioro EP, Pletnikova O, Pliner HA, Pulst SM, Ravits JM, Renton AE, Rivera A, Robberecht W, Rogaeva E, Rollinson S, Rothstein JD, Scholz SW, Sendtner M, Shaw PJ, Sidle KC, Simmons Z, Singleton AB, Smith N, Stone DJ, Tienari PJ, Troncoso JC, Valori M, Van Damme P, Van Deerlin VM, Van Den Bosch L, Zinman L, Landers JE, Chiò A, Traynor BJ, Angelocola SM, Ausiello FP, Barberis M, Bartolomei I, Battistini S, Bersano E, Bisogni G, Borghero G, Brunetti M, Cabona C, Calvo A, Canale F, Canosa A, Cantisani TA, Capasso M, Caponnetto C, Cardinali P, Carrera P, Casale F, Chiò A, Colletti T, Conforti FL, Conte A, Conti E, Corbo M, Cuccu S, Dalla Bella E, D'Errico E, DeMarco G, Dubbioso R, Ferrarese C, Ferraro PM, Filippi M, Fini N, Floris G, Fuda G, Gallone S, Gianferrari G, Giannini F, Grassano M, Greco L, Iazzolino B, Introna A, La Bella V, Lattante S, Lauria G, Liguori R, Logroscino G, Logullo FO, Lunetta C, Mandich P, Mandrioli J, Manera U, Manganelli F, Marangi G, Marinou K, Marrosu MG, Martinelli I, Messina S, Moglia C, Mora G, Mosca L, Murru MR, Origone P, Passaniti C, Petrelli C, Petrucci A, Pozzi S, Pugliatti M, Quattrini A, Ricci C, Riolo G, Riva N, Russo M, Sabatelli M, Salamone P, Salivetto M, Salvi F, Santarelli M, Sbaiz L, Sideri R, Simone I, Simonini C, Spataro R, Tanel R, Tedeschi G, Ticca A, Torriello A, Tranquilli S, Tremolizzo L, Trojsi F, Vasta R, Vacchiano V, Vita G, Volanti P, Zollino M, Zucchi E

• Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2021 Oct;18(4):2541-2564 Epub 2021 Sep 15; Authors: Bhatia TN, Clark RN, Needham PG, Miner KM, Jamenis AS, Eckhoff EA, Abraham N, Hu X, Wipf P, Luk KC, Brodsky JL, Leak RK

• Helicobacter pylori, periodontal pathogens, and their interactive association with incident all-cause and Alzheimer's disease dementia in a large national survey.
  Molecular psychiatry. 2021 Oct;26(10):6038-6053 Epub 2020 May 4; Authors: Beydoun MA, Beydoun HA, Weiss J, Hossain S, El-Hajj ZW, Zonderman AB

• Validation and demonstration of a new comprehensive model of Alzheimer's disease progression.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Oct;17(10):1698-1708 Epub 2021 May 14; Authors: Stern Y, Stallard E, Kinosian B, Zhu C, Cosentino S, Jin Z, Gu Y

• Mass spectrometry-based methods for robust measurement of Alzheimer's disease biomarkers in biological fluids.
  Journal of neurochemistry. 2021 Oct;159(2):211-233 Epub 2021 Aug 25; Authors: Korecka M, Shaw LM

• New strategies for fluorescently labeling proteins in the study of amyloids.
  Current opinion in chemical biology. 2021 Oct;64:57-66 Epub 2021 Jun 3; Authors: Shimogawa M, Petersson EJ

• Outcomes of post-acute care in skilled nursing facilities in Medicare beneficiaries with and without a diagnosis of dementia.
  Journal of the American Geriatrics Society. 2021 Oct;69(10):2899-2907 Epub 2021 Jun 25; Authors: Burke RE, Xu Y, Ritter AZ

• TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy.
  Acta neuropathologica. 2021 Oct;142(4):629-642 Epub 2021 Jun 21; Authors: Mao F, Robinson JL, Unger T, Posavi M, Amado DA, Elman L, Grossman M, Wolk DA, Lee EB, Van Deerlin VM, Porta S, Lee VMY, Trojanowski JQ, Chen-Plotkin AS

• Persistence of Lipoproteins and Cholesterol Alterations after Sepsis: Implication for Atherosclerosis Progression.
  International journal of molecular sciences. 2021 Sep 29;22(19); Authors: Laudanski K

• The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function.
  Cell. 2021 Sep 16;184(19):4981-4995.e14 Epub 2021 Aug 30; Authors: Johnson LR, Lee DY, Eacret JS, Ye D, June CH, Minn AJ

• Genetic Overlap Profiles of Cognitive Ability in Psychotic and Affective Illnesses: A Multisite Study of Multiplex Pedigrees.
  Biological psychiatry. 2021 Sep 15;90(6):373-384 Epub 2021 Mar 17; Authors: Knowles EEM, Peralta JM, Almasy L, Nimgaonkar V, McMahon FJ, McIntosh AM, Thomson P, Mathias SR, Gur RC, Curran JE, Raventós H, Contreras J, Jablensky A, Badcock J, Blangero J, Gur RE, Glahn DC

• Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life.
  Proceedings of the National Academy of Sciences of the United States of America. 2021 Sep 14;118(37); Authors: Jenkins LM, Kogan A, Malinab M, Ingo C, Sedaghat S, Bryan NR, Yaffe K, Parrish TB, Nemeth AJ, Lloyd-Jones DM, Launer LJ, Wang L, Sorond F

• Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia.
  The journals of gerontology. Series A, Biological sciences and medical sciences. 2021 Sep 13;76(10):1829-1838; Authors: Wadley VG, Bull TP, Zhang Y, Barba C, Bryan RN, Crowe M, Desiderio L, Deutsch G, Erus G, Geldmacher DS, Go R, Lassen-Greene CL, Mamaeva OA, Marson DC, McLaughlin M, Nasrallah IM, Owsley C, Passler J, Perry RT, Pilonieta G, Steward KA, Kennedy RE

• Implications of FDA Approval of a First Disease-Modifying Therapy for a Neurodegenerative Disease on the Design of Subsequent Clinical Trials.
  Neurology. 2021 Sep 7;97(10):496-500 Epub 2021 Jun 4; Authors: Grill JD, Karlawish J

• TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
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• α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.
  Movement disorders : official journal of the Movement Disorder Society. 2021 Sep;36(9):2036-2047 Epub 2021 Feb 6; Authors: Uemura N, Ueda J, Yoshihara T, Ikuno M, Uemura MT, Yamakado H, Asano M, Trojanowski JQ, Takahashi R

• Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics.
  Annals of neurology. 2021 Sep;90(3):366-376 Epub 2021 Jun 17; Authors: Sariya S, Felsky D, Reyes-Dumeyer D, Lali R, Lantigua RA, Vardarajan B, Jiménez-Velázquez IZ, Haines JL, Shellenberg GD, Pericak-Vance MA, Paré G, Mayeux R, Tosto G

• Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction.
  Trends in neurosciences. 2021 Sep;44(9):728-740 Epub 2021 Jul 20; Authors: Saikumar J, Bonini NM

• Adaptation and validation of a computerized neurocognitive battery in the Xhosa of South Africa.
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• The approval of Aduhelm risks eroding public trust in Alzheimer research and the FDA.
  Nature reviews. Neurology. 2021 Sep;17(9):523-524; Authors: Karlawish J, Grill JD

• The Problem of Aducanumab for the Treatment of Alzheimer Disease.
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• Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients With Progranulin Gene Haploinsufficiency: A Randomized Clinical Trial.
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• Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer's disease.
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• Of mice and men: What a mouse model of microglial C9ORF72 deficiency does-and does not-tell us about human neurodegenerative diseases.
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• Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis.
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