2d
a
10
1e
e
c
26
4d
16
11
19
1
49
2
12
1b
1d
18
34
63
1d
2 29
1d
25
Anne Rentoumis Cappola
78
63
Professor of Medicine (Endocrinology, Diabetes and Metabolism)
28
88
3
5f
Attending Physician, Hospital of the University of Pennsylvania, Philadelphia, PA
80
Fellow, Institute on Aging, University of Pennsylvania School of Medicine
9c
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine
a3
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
86
Member, Cardiovascular Institute, University of Pennsylvania School of Medicine
78
Executive Director, Penn Medical Communication Research Institute
b8
Director, Division of Geroscience, Gerontology, and Geriatrics, Institute on Aging, University of Pennsylvania School of Medicine
11
Department: Medicine
4
1
b
1d
46
Contact information
61
4
3
3
1d
61
Division of Endocrinology, Diabetes, and Metabolism
13 Room 12-136
3c Smilow Center for Translational Research, 12th floor
4d 3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
26
13 Room 12-136
3c Smilow Center for Translational Research, 12th floor
4d 3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
30
Office: (215) 573-5634
34 Fax: (215) 898-5408
24
f
34 Fax: (215) 898-5408
24
18
Publications
23 a
3
2
4
b
1f
23 a
13
Education:
21 9 B.A. 1a (Biochemistry ) c
4b Harvard College (Advanced Standing), Cambridge, MA, 1990.
21 9 M.D. c
46 University of Pennsylvania School of Medicine, 1994.
21 a Sc.M. 22 (Clinical Epidemiology) c
57 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
c
3
27
21 9 B.A. 1a (Biochemistry ) c
4b Harvard College (Advanced Standing), Cambridge, MA, 1990.
21 9 M.D. c
46 University of Pennsylvania School of Medicine, 1994.
21 a Sc.M. 22 (Clinical Epidemiology) c
57 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
c
Links
98 Search PubMed for articles
81 School of Medicine Faculty
9d Division of Endocrinology, Diabetes, and Metabolism Faculty
c
5
21
98 Search PubMed for articles
81 School of Medicine Faculty
9d Division of Endocrinology, Diabetes, and Metabolism Faculty
c
1f
Post-Graduate Training
24 6e Intern and Resident, Internal Medicine, Brigham and Women's Hospital, Boston, MA, 1994-1997.
24 68 Clinical Fellow, Endocrinology, Massachusetts General Hospital, Boston, MA, 1997-1998.
24 7f Clinical and Research Fellow, Endocrinology and Metabolism, Johns Hopkins Hospital, Baltimore, MD, 1998-2000.
24 7c Research Fellow, Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD, 1999-2001.
24 65 Senior Honorary Visiting Fellow, University of Cambridge, Cambridge, UK, 2013-2014.
c
3
25
24 6e Intern and Resident, Internal Medicine, Brigham and Women's Hospital, Boston, MA, 1994-1997.
24 68 Clinical Fellow, Endocrinology, Massachusetts General Hospital, Boston, MA, 1997-1998.
24 7f Clinical and Research Fellow, Endocrinology and Metabolism, Johns Hopkins Hospital, Baltimore, MD, 1998-2000.
24 7c Research Fellow, Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD, 1999-2001.
24 65 Senior Honorary Visiting Fellow, University of Cambridge, Cambridge, UK, 2013-2014.
c
17
Certifications
28 5f American Board of Internal Medicine Certification in Internal Medicine, 1997.
28 6a American Board of Internal Medicine Certification in Endocrinology and Metabolism, 1999.
28 39 American College of Epidemiology, 2004.
28 6c American Board of Internal Medicine Recertification in Endocrinology and Metabolism, 2009.
28 6c American Board of Internal Medicine Recertification in Endocrinology and Metabolism, 2019.
c
3
90
Permanent link28 5f American Board of Internal Medicine Certification in Internal Medicine, 1997.
28 6a American Board of Internal Medicine Certification in Endocrinology and Metabolism, 1999.
28 39 American College of Epidemiology, 2004.
28 6c American Board of Internal Medicine Recertification in Endocrinology and Metabolism, 2009.
28 6c American Board of Internal Medicine Recertification in Endocrinology and Metabolism, 2019.
c
2 29
21
1e
1d
24
5e
8
16b Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies defining cutoffs for thyroid dysfunction in older men and women, the role of thyroid hormone treatment in cardiovascular disease, and optimization of the management of hypothyroidism.
e 29
27
Description of Research Expertise
12f Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism and Exeutive Director of the Penn Medical Communication Research Institute (PMCRI). She is Senior Editor for the Journal of the American Medical Association (JAMA).8
16b Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies defining cutoffs for thyroid dysfunction in older men and women, the role of thyroid hormone treatment in cardiovascular disease, and optimization of the management of hypothyroidism.
e 29
23
255 Hysaj O, Efthimiou O, Collet TH, Cappola AR, Alwan H, Gussekloo J, Chaker L, Kavousi M, Azizi F, Köttgen A, Selvin E, Trompet S, Walsh JP, Brown SJ, Iacoviello M, Dullaart RPF, Bakker SJL, Sgarbi JA, Ittermann T, Völzke H, Benseñor IM, Valdés S, Maldonado-Araque C, Psaty BM, Wolters FJ, Åsvold BO, Del Giovane C, Rodondi N: Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts. Eur J Endocrinol 193(5): S71-S82, Oct 2025.
e2 Cohen KS, Fallik D, Cappola AR: The role of family as a source of health information among college students. J Community Health 50(4): 613-622, Aug 2025.
9d Cappola AR, Abraham DS, Kroopnick JM, Huang Y, Hochberg MC, Miller RR, Shardell M, Hicks GE, Orwig D, Magaziner J ea : Sex-specific associations of vitamin D and bone biomarkers with bone density and physical function during recovery from hip fracture: the Baltimore Hip Studies. Osteoporos Int 36(5): 855-863, May 2025.
256 Baretella O, Blum MR, Abolhassani N, Alwan H, Wildisen L, Del Giovane C, Tal K, Moutzouri E, Åsvold BO, Cappola AR, Gussekloo J, Iacoviello M, Iervasi G, Imaizumi M, Weiler S, Razvi S, Sgarbi JA, Völzke H, Brown SJ, Walsh JP, Vaes B, Yeap BB, Dullaart RPF, Bakker SJL, Kavousi M, Ceresini G, Ferrucci L, Aujesky D, Peeters RP, Bauer DC, Feller M, Rodondi N: Associations between subclinical thyroid dysfunction and cardiovascular risk factors according to age and sex. J Clin Endocrinol Metab 110(5): e1315-e1322, Apr 2025.
17a Wade AN, Guare L, Hayat M, Straub P, Gao Z, Medici M, Teumer A, Davis LK, Ramsay M, Ritchie MD, Cappola AR: Strength of genetic associations with thyroid stimulating hormone values differs between populations with similarity to African and European reference populations. Thyroid 35(2): 131-142, Feb 2025.
15f Unachukwu IC, Adjei-Poku MN, Sailors OC, Gonzales R, South E, Meisel Z, Kelz RR, Cappola AR, Friedman AB: Images in black and white: disparities in utilization of computed tomography and ultrasound for older adults with abdominal pain. West J Emerg Med 26(3): 452-457, Feb 2025.
139 Wu RR, Adjei-Poku MN, Kelz RR, Peck GL, Hwang U, Cappola AR, Friedman AB: Trends in visits, imaging, and diagnosis for emergency department abdominal pain presentations in the United States, 2007-2019. Acad Emerg Med 32(1): 20-31, Jan 2025.
13e Barasch E, Gottdiener J, Buzkova P, Cappola AR, Shah S, DeFilippi C, Gardin J, Kizer JR: Association of thyroid dysfunction in individuals ≥ 65 years of age with subclinical cardiac abnormalities. J Clin Endocrinol Metab 109(10), Sep 2024.
101 Seedat F, Tollman SM, Twine W, Cappola AR, Wade AN: Double malnutrition and associated factors in a middle-aged and older, rural South African population. BMC Nutr 10(1): 84, Jun 2024.
2c
7
1d
1f
Selected Publications
131 Ettleson MD, Thomas N, Wan W, Hedeker D, Cappola AR, Laiteerapong N, Bianco AC: Suboptimal levothyroxine treatment is associated with increases in mean blood pressure and blood pressure variability. J Clin Endocrinol Metab Dec 2025.255 Hysaj O, Efthimiou O, Collet TH, Cappola AR, Alwan H, Gussekloo J, Chaker L, Kavousi M, Azizi F, Köttgen A, Selvin E, Trompet S, Walsh JP, Brown SJ, Iacoviello M, Dullaart RPF, Bakker SJL, Sgarbi JA, Ittermann T, Völzke H, Benseñor IM, Valdés S, Maldonado-Araque C, Psaty BM, Wolters FJ, Åsvold BO, Del Giovane C, Rodondi N: Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts. Eur J Endocrinol 193(5): S71-S82, Oct 2025.
e2 Cohen KS, Fallik D, Cappola AR: The role of family as a source of health information among college students. J Community Health 50(4): 613-622, Aug 2025.
9d Cappola AR, Abraham DS, Kroopnick JM, Huang Y, Hochberg MC, Miller RR, Shardell M, Hicks GE, Orwig D, Magaziner J ea : Sex-specific associations of vitamin D and bone biomarkers with bone density and physical function during recovery from hip fracture: the Baltimore Hip Studies. Osteoporos Int 36(5): 855-863, May 2025.
256 Baretella O, Blum MR, Abolhassani N, Alwan H, Wildisen L, Del Giovane C, Tal K, Moutzouri E, Åsvold BO, Cappola AR, Gussekloo J, Iacoviello M, Iervasi G, Imaizumi M, Weiler S, Razvi S, Sgarbi JA, Völzke H, Brown SJ, Walsh JP, Vaes B, Yeap BB, Dullaart RPF, Bakker SJL, Kavousi M, Ceresini G, Ferrucci L, Aujesky D, Peeters RP, Bauer DC, Feller M, Rodondi N: Associations between subclinical thyroid dysfunction and cardiovascular risk factors according to age and sex. J Clin Endocrinol Metab 110(5): e1315-e1322, Apr 2025.
17a Wade AN, Guare L, Hayat M, Straub P, Gao Z, Medici M, Teumer A, Davis LK, Ramsay M, Ritchie MD, Cappola AR: Strength of genetic associations with thyroid stimulating hormone values differs between populations with similarity to African and European reference populations. Thyroid 35(2): 131-142, Feb 2025.
15f Unachukwu IC, Adjei-Poku MN, Sailors OC, Gonzales R, South E, Meisel Z, Kelz RR, Cappola AR, Friedman AB: Images in black and white: disparities in utilization of computed tomography and ultrasound for older adults with abdominal pain. West J Emerg Med 26(3): 452-457, Feb 2025.
139 Wu RR, Adjei-Poku MN, Kelz RR, Peck GL, Hwang U, Cappola AR, Friedman AB: Trends in visits, imaging, and diagnosis for emergency department abdominal pain presentations in the United States, 2007-2019. Acad Emerg Med 32(1): 20-31, Jan 2025.
13e Barasch E, Gottdiener J, Buzkova P, Cappola AR, Shah S, DeFilippi C, Gardin J, Kizer JR: Association of thyroid dysfunction in individuals ≥ 65 years of age with subclinical cardiac abnormalities. J Clin Endocrinol Metab 109(10), Sep 2024.
101 Seedat F, Tollman SM, Twine W, Cappola AR, Wade AN: Double malnutrition and associated factors in a middle-aged and older, rural South African population. BMC Nutr 10(1): 84, Jun 2024.
2c