faculty photo

Douglas C Wallace, PhD

Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia Research Institute
The Colket Translational Research Building, Rm 6060
3501 Civic Center Boulevard
Philadelphia, PA 19104-4302
Office: 267-425-3034
Education:
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.
Post-Graduate Training
Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.
Permanent link
 
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Selected Publications

Flierl A, Schriner SE, Hancock S, Coskun PE, Wallace DC.: The mitochondrial adenine nucleotide transporters in myogenesis. Epub 2022.

Enguita FJ, Leitão AL, McDonald JT, Zaksas V, Das S, Galeano D, Taylor D, Wurtele ES, Saravia-Butler A, Baylin SB, Meller R, Porterfield DM, Wallace DC, Schisler JC, Mason CE, Beheshti A. : The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune response. eCollection 2022.

Weiss SL, Zhang D, Farooqi S, Wallace DC. : Sodium butyrate reverses lipopolysaccharide-induced mitochondrial dysfunction in lymphoblasts. Epub 2022.

Lee C, Chen Y, Wang P, Wallace DC, Burke PJ. : A Three-Dimensional Printed Inertial Microfluidic Platform for Isolation of Minute Quantities of Vital Mitochondria. Epub 2022.

Schaefer PM, Rathi K, Butic A, Tan W, Mitchell K, Wallace DC: Mitochondrial mutations alter endurance exercise response and determinants in mice. Epub 2022.

Wang J, Balciuniene J, Diaz-Miranda MA, McCormick EM, Aref-Eshghi E, Muir AM, Cao K, Troiani J, Moseley A, Fan Z, Zolkipli-Cunningham Z, Goldstein A, Ganetzky RD, Muraresku CC, Peterson JT, Spinner NB, Wallace DC, Dulik MC, Falk MJ. : Advanced approach for comprehensive mtDNA genome testing in mitochondrial disease. Epub 2022.

Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, Soto Albrecht Y, Murdock DG, Angelin A, Singh LN, Weiss SL, Best SM, Lott MT, Cope H Zaksas V, Saravia-Butler A, Meydan C, Foox J, Mozsary C, Kidane YH, Priebe W, Emmett M, Meller R, View ORCID Profile Singh U, Bram Y, tenOever BR, Heise MT, Moorman NJ, Madden EA,Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Baxter VK, Baylin S, Wurtele E, Moraes-vieira P, Taylor D, Mason C, e Schisler JC, Schwartz RE, Beheshti A, Wallace DC. : Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection. Science Translational Medicine 2022.

Weiss SL, Henrickson SE, Lindell RB, Sartori LF, Zhang D, Bush J, Farooqi S, Starr J, Deutschman CS, McGowan FX Jr, Becker L, Tuluc F, Wherry EJ, Picard M, Wallace DC. : Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children with Sepsis.Shock. Science 2022.

Lindell RB, Zhang D, Bush J, Wallace DC, Rabinowitz JD, Lu W, Wherry EJ, Weiss SL, Henrickson SE.: Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associated with Features of Immunometabolic Dysregulation. Shock 2022.

Kopinski PK, Singh LN, Zhang S, Lott MT, Wallace DC: Mitochondrial DNA variation and cancer. Nat Rev Cancer. 2021.

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Last updated: 10/03/2022
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