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Robert O. Heuckeroth, M.D. Ph.D.
69Professor of Pediatrics (Gastroenterology, Hepatology and Nutrition)
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Department: Pediatrics
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Graduate Group Affiliations
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- Neuroscience 5c
- Immunology 41
- Bioengineering 6a
- Pharmacology 6b
- Cell and Molecular Biology e
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Contact information
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Robert O. Heuckeroth M.D. Ph.D.
44 The Children's Hospital of Philadelphia - Research Institute
1e 3615 Civic Center Blvd
4f Abramson Research Center -Suite # 1116i
Philadelphia, PA 19104-4318
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44 The Children's Hospital of Philadelphia - Research Institute
1e 3615 Civic Center Blvd
4f Abramson Research Center -Suite # 1116i
Philadelphia, PA 19104-4318
2e
Office: 215-590-1209
32 Fax: 215-590-3324
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32 Fax: 215-590-3324
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Email:
Heuckerothr@email.chop.edu
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Heuckerothr@email.chop.edu
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Education:
21 9 B.S. 45 (Chemistry, Summa Cum Laude with high honors in chemistry) c
2f University of Maryland, 1983.
21 a Ph.D. 19 (Biochemistry) c
4c Washington University School of Medicine, St. Louis, 1990.
21 9 M.D. c
4c Washington University School of Medicine, St. Louis, 1990.
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21 9 B.S. 45 (Chemistry, Summa Cum Laude with high honors in chemistry) c
2f University of Maryland, 1983.
21 a Ph.D. 19 (Biochemistry) c
4c Washington University School of Medicine, St. Louis, 1990.
21 9 M.D. c
4c Washington University School of Medicine, St. Louis, 1990.
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Post-Graduate Training
24 53 Resident in Pediatrics, St. Louis Children's Hospital, 1990-1992.
24 76 Clinical Fellow, Pediatric Gastroenterology and Nutrition, St. Louis Children's Hospital, 1992-1993.
24 57 Research Fellow, Washington University School of Medicine, 1993-1995.
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Permanent link24 53 Resident in Pediatrics, St. Louis Children's Hospital, 1990-1992.
24 76 Clinical Fellow, Pediatric Gastroenterology and Nutrition, St. Louis Children's Hospital, 1992-1993.
24 57 Research Fellow, Washington University School of Medicine, 1993-1995.
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3a Projects we are currently pursuing include:
5f 1. Defining genetics of Hirschsprung disease and intestinal pseudoobstruction syndrome.
54 2. Identifying gene-environment interactions that cause human birth defects.
5b 3. Determining mechanisms to control the fate of enteric nervous system stem cells.
77 4. Developing regenerative medicine approaches to care for children with serious intestinal motility disorders.
7e 5. Establishing translational research programs to improve visualization of the enteric nervous system and bowel wall.
36 6. Personalized medicine approaches to therapy.
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Description of Clinical Expertise
aa Pediatric gastroenterologist with more than 20 years experience taking care of children with a wide array of complex bowel, liver and pancreatic diseases.71
Description of Research Expertise
27e Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development. This work involves a combination of molecular biology, genetics, live cell imaging, primary cell culture, epidemiology, physiology, biochemistry, stem cell biology and regenerative medicine. Since the enteric nervous system is derived from actively migrating, proliferating and differentiating neural crest cells, we have broad interests in the complex processes that govern normal and abnormal development with the long term goal of finding new ways to prevent birth defects and to repair damaged organs.8
3a Projects we are currently pursuing include:
5f 1. Defining genetics of Hirschsprung disease and intestinal pseudoobstruction syndrome.
54 2. Identifying gene-environment interactions that cause human birth defects.
5b 3. Determining mechanisms to control the fate of enteric nervous system stem cells.
77 4. Developing regenerative medicine approaches to care for children with serious intestinal motility disorders.
7e 5. Establishing translational research programs to improve visualization of the enteric nervous system and bowel wall.
36 6. Personalized medicine approaches to therapy.
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13c Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO : Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. Journal for Clinical Investigation 123(12): 5152-64, Dec 2013.
10d Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO: Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function. Developmental Biology 381(1): 28-37, Sep 2013.
171 Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW: Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection. American Journal of Physiology - Gastrointestinal & Liver Physiology 302(10): G1143-50, May 15 2012.
126 Viader A, Wright-Jin EC, Vohra BPS, Heuckeroth RO, Milbrandt J: Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction. PLoS ONE [Electronic Resource] 6(11): e27727, 2011.
118 Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO: Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation. Development 137(4): 631-40, Feb 2010.
167 Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BPS, Keller-Peck C, Heuckeroth RO: The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. Journal of Neuroscience 30(4): 1523-38, Jan 27 2010.
136 Lake J, Heuckeroth RO : Enteric nervous system development: Migration, differentiation and disease. American Journal of Physiology: Gastrointestinal and Liver Physiology 305(1): G1-G24, July 2013 Notes: Selected as an “Editor’s Pick” (PMID 2369815) 32 DOI: 10.1152/ajpgi.00452.2012.
102 Heuckeroth RO : Hirschsprung disease Pediatric Neurogastroenterology. Faure C, DiLorenzo C, Thapar N (eds.). Humana Press, New York, Heidelberg, Dordrecht, London Page: 271-283, 2013
10a Heuckeroth RO: Congenital and Acquired Disorders of the Enteric Nervous System. Translational Gastroenterology: Organogenesis to Disease. Samuelson LC, Gumucio DL (eds.). Wiley-Blackwell, 2014.
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Selected Publications
106 Lake JI, Tusheva OA, Graham BL, Heuckeroth RO: Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis. Journal for Clinical Investigation 123(11): 4875-87, November 2013.13c Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO : Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. Journal for Clinical Investigation 123(12): 5152-64, Dec 2013.
10d Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO: Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function. Developmental Biology 381(1): 28-37, Sep 2013.
171 Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW: Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection. American Journal of Physiology - Gastrointestinal & Liver Physiology 302(10): G1143-50, May 15 2012.
126 Viader A, Wright-Jin EC, Vohra BPS, Heuckeroth RO, Milbrandt J: Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction. PLoS ONE [Electronic Resource] 6(11): e27727, 2011.
118 Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO: Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation. Development 137(4): 631-40, Feb 2010.
167 Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BPS, Keller-Peck C, Heuckeroth RO: The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. Journal of Neuroscience 30(4): 1523-38, Jan 27 2010.
136 Lake J, Heuckeroth RO : Enteric nervous system development: Migration, differentiation and disease. American Journal of Physiology: Gastrointestinal and Liver Physiology 305(1): G1-G24, July 2013 Notes: Selected as an “Editor’s Pick” (PMID 2369815) 32 DOI: 10.1152/ajpgi.00452.2012.
102 Heuckeroth RO : Hirschsprung disease Pediatric Neurogastroenterology. Faure C, DiLorenzo C, Thapar N (eds.). Humana Press, New York, Heidelberg, Dordrecht, London Page: 271-283, 2013
10a Heuckeroth RO: Congenital and Acquired Disorders of the Enteric Nervous System. Translational Gastroenterology: Organogenesis to Disease. Samuelson LC, Gumucio DL (eds.). Wiley-Blackwell, 2014.
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Contact us
4eInstitute for Diabetes, Obesity and Metabolism
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Smilow Center for Translational Research
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3400 Civic Center Boulevard, 12th Floor
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Philadelphia, PA 19104
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Phone: 215-898-0198 | Fax 215-898-5408
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Directions
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