1d
2
2
20
5
5
1e
5
1d
19a
c
27
1a
3f
21
c
1c
15
2
7
15
5
21
5
3
6
17
4
4
2
22
3
1a
4
8
1c
c
3
60
9
c
In Memoriam
16
19
1
49
2
6
d
1b
1d
18
79
31
1d
2 29
1d
25
31
Franz M. Matschinsky
2b 7 72Department: Biochemistry and Biophysics
4
1
b
1d
46
Contact information
72
4
3
3
1d
72
12-125 Translational Research Center
Philadelphia, PA 19104-6015
26
Philadelphia, PA 19104-6015
30
Office: (215) 898-1971
34 Fax: (215) 898-2178
24
93
34 Fax: (215) 898-2178
24
Email:
MATSCH@MAIL.MED.UPENN.EDU
12
MATSCH@MAIL.MED.UPENN.EDU
18
Publications
23 a
3
2
4
b
1f
23 a
13
Education:
21 9 B.S. 22 (Basic Medical Science) c
35 Albert Ludwig University, Freiburg, West Germany 16 , 1955.
21 9 M.D. c
43 Ludwig-Maximalian Unviersity, West Germany, 1958.
c
3
27
5
21
21 9 B.S. 22 (Basic Medical Science) c
35 Albert Ludwig University, Freiburg, West Germany 16 , 1955.
21 9 M.D. c
43 Ludwig-Maximalian Unviersity, West Germany, 1958.
c
1f
Post-Graduate Training
24 75 Postdoctoral Fellow in Biochemistry, Ludwig-Maximilian University, Munich, West Germany, 1959-1962.
24 56 Intern , Marien Hospital, Hagen, Westfalen, West Germany, 1962-1963.
24 76 Postdoctoral Fellow in Pharmacology, Washington University Medical School, St. Louis, MO, 1963-1965.
c
3
3
8b
Permanent link24 75 Postdoctoral Fellow in Biochemistry, Ludwig-Maximilian University, Munich, West Germany, 1959-1962.
24 56 Intern , Marien Hospital, Hagen, Westfalen, West Germany, 1962-1963.
24 76 Postdoctoral Fellow in Pharmacology, Washington University Medical School, St. Louis, MO, 1963-1965.
c
2 29
21
1e
1d
24
5e
26 29
27
Description of Research Expertise
305 The laboratory studies the biochemical basis of fuel sensing by pancreatic islet cells, in particular the molecular mechanisms of glucose sensing and glucose stimulated insulin release (GSIR). The endocrine, neural and pharmacological modification of GSIR is another focus of the laboratory. The molecular genetic basis of glucokinase (GK) linked hypo-and hyperglycemia syndromes which are caused by more than 130 mutations of the GK gene continue to be a topic of intense interest. A newly discovered class of pharmacological agents called GK activators (GKAs) are studied with recombinant human wildtype and mutant GK, with intact pancreatic islet cells and in the intact animal to assess there therapeutic potential for the treatment of type II diabetes.26 29
23
124 Cabrera-Valladares G, Matschinsky FM, Wang J, Fernandez-Mejia C : Effect of retinoic acid on glucokinase activity and gene expression in neonatal and adult cultured hepatocytes Life Sciences 68(25): 2813-2824, 2001.
156 Njolstad PR, Sovic O, Cuesta-Munoz A, Bjorkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI : Neonatal diabetes mellitus due to complete glucokinase deficiency New England Journal of Medicine 344(21): 1588-1592, 2001.
157 Fernandez-Mejia C, Vega-Allende J, Rojas-Ochoa A, Rodriguez-Dorantes M, Romero-Navarro G, Matschinsky FM, Wang J, German MS : Cyclic adenosine 3’,5’-monophosphate increases pancreatic glucokinase activity and gene expression Endocrinology 142(4): 1448-1452, 2001.
24b O Massa, F Meschi, A Cuesta-Munoz, A Caumo, F Cerutti, S Toni, V Cherubini, L Guazzarotti, N Sulli, FM Matschinsky, R Lorini, D Iafusco, F Barbetti, and Italian Society of Paediatic Endocrinology and Diabetes (SIEDP): High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP) Diabetologia 44(7): 898-905, uly 2001.
aa FM Matschinsky: Ebb and tide of glucokinase Int J Exp Diabetes Res 2(3): 168-171, January 2001.
136 Grimsby J, Coffey JW, Dovorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF : Characterization of glucokinase regulatory protein deficient mice Journal of Biological Chemistry 275(1): 7829-7831, 2000.
141 Newgard C.B. and Matschinsky FM : Substrate Control of Insulin Release Chapter 5, Section 7: The Endocrine System, Vol. II: The Endocrine Pancreas and Regulation of Metabolism, Handbook of Physiology. Oxford University Press, Page: 125-151, 2000.
11f Grimsby J, Coffey JW, Dovorozniak MT, Li G, Matschinsky FM, Shiota C, Magnuson MA, Grippo JF: Characterization of glucokinase regulatory protein deficient mice Diabetes Abstracts (Suppl. 1): #1775 48: A402, 1999.
16a Davis EA, Cuesta-Mu„§oz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM: Mutants of Glucokinase Cause Hypo- and Hyperglycemia Syndromes and Their Analysis Illuminates Fundamental Quantitative Concepts of Glucose Homeostasis Diabetologia 42(10): 1175-1186, 1999.
2c
7
1d
1f
Selected Publications
b7 Sund NJ. Vatamaniuk MZ. Casey M. Ang SL. Magnuson MA. Stoffers DA. Matschinsky FM. Kaestner KH: Tissue-specific deletion of Foxa2 in 83 pancreatic B- cells results in hyperinsulinemic hypoglycemia Genes & Development 15(13): 1706-1715, 2001.124 Cabrera-Valladares G, Matschinsky FM, Wang J, Fernandez-Mejia C : Effect of retinoic acid on glucokinase activity and gene expression in neonatal and adult cultured hepatocytes Life Sciences 68(25): 2813-2824, 2001.
156 Njolstad PR, Sovic O, Cuesta-Munoz A, Bjorkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI : Neonatal diabetes mellitus due to complete glucokinase deficiency New England Journal of Medicine 344(21): 1588-1592, 2001.
157 Fernandez-Mejia C, Vega-Allende J, Rojas-Ochoa A, Rodriguez-Dorantes M, Romero-Navarro G, Matschinsky FM, Wang J, German MS : Cyclic adenosine 3’,5’-monophosphate increases pancreatic glucokinase activity and gene expression Endocrinology 142(4): 1448-1452, 2001.
24b O Massa, F Meschi, A Cuesta-Munoz, A Caumo, F Cerutti, S Toni, V Cherubini, L Guazzarotti, N Sulli, FM Matschinsky, R Lorini, D Iafusco, F Barbetti, and Italian Society of Paediatic Endocrinology and Diabetes (SIEDP): High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP) Diabetologia 44(7): 898-905, uly 2001.
aa FM Matschinsky: Ebb and tide of glucokinase Int J Exp Diabetes Res 2(3): 168-171, January 2001.
136 Grimsby J, Coffey JW, Dovorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF : Characterization of glucokinase regulatory protein deficient mice Journal of Biological Chemistry 275(1): 7829-7831, 2000.
141 Newgard C.B. and Matschinsky FM : Substrate Control of Insulin Release Chapter 5, Section 7: The Endocrine System, Vol. II: The Endocrine Pancreas and Regulation of Metabolism, Handbook of Physiology. Oxford University Press, Page: 125-151, 2000.
11f Grimsby J, Coffey JW, Dovorozniak MT, Li G, Matschinsky FM, Shiota C, Magnuson MA, Grippo JF: Characterization of glucokinase regulatory protein deficient mice Diabetes Abstracts (Suppl. 1): #1775 48: A402, 1999.
16a Davis EA, Cuesta-Mu„§oz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM: Mutants of Glucokinase Cause Hypo- and Hyperglycemia Syndromes and Their Analysis Illuminates Fundamental Quantitative Concepts of Glucose Homeostasis Diabetologia 42(10): 1175-1186, 1999.
2c
7
1e
18
18
6
9
b
26
b
22
10
cb
22
31
22
Contact us
4eInstitute for Diabetes, Obesity and Metabolism
3b
Smilow Center for Translational Research
37
3400 Civic Center Boulevard, 12th Floor
2a
Philadelphia, PA 19104
3a
Phone: 215-898-0198 | Fax 215-898-5408
31
12
Directions
120
18
37
e
54
10
© Trustees of the University of Pennsylvania
12