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Mingyao Li

Associate Professor of Biostatistics in Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology

Contact information
University of Pennsylvania School of Medicine
Department of Biostatistics and Epidemiology
213 Blockley Hall, 423 Guardian Drive
Philadelphia, PA 19104
Office: 215-746-3916
Fax: 215-573-4865
B.S. (Mathematics)
Nankai University, China, 1996.
M.S. (Mathematics)
Nankai University, China, 1999.
M.S. (Biostatistics)
University of Michigan, 2002.
Ph.D. (Biostatistics)
University of Michigan, 2005.
Post-Graduate Training
Postdoctoral Research Fellow, Center for Statistical Genetics, University of Michigan, 2005-2005.
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Description of Research Expertise

Dr. Mingyao Li joined the Biostatistics faculty in 2006. She is also a faculty member of the Genomics and Computational Biology (GCB) graduate program. Her main research area is statistical genetics, bioinformatics and computational biology. In particular, she is interested in developing statistical methods and computational tools for identifying and characterizing genetic variants that influence susceptibility to complex diseases. Her current research work involves the analysis of high-throughput genetics/genomics data such as those generated from next-generation sequencing studies. She is particularly interested in the analysis of admixed populations, RNA-sequencing data, and genetics of gene expression. In addition to methods development, Dr. Li is also interested in collaborating with researchers seeking to identify complex disease susceptibility genes. Her collaborative research includes studies of the genetics of cardiometabolic diseases and eye diseases. Dr. Li actively serves in the scientific community. She is an Associate Editor of Statistics in Biosciences, and is a regular member of the Genomics, Computational Biology and Technology (GCAT) study section and a member of the review committee of the Center for Inherited Disease Research (CIDR) of the NIH.

Selected Publications

Murillo G.H., You N., Su X., Cui W., Reilly M.P., Li M., Ning K., Cui X.: MultiGeMS: detection of SNVs from multiple samples using model selection on high-throughput sequencing data. Bioinformatics January 2016 Notes: in press.

Fritsche L.G., Igl W., Bailey J.N., Grassmann F., Sengupta S., Bragg-Gresham J.L., Burdon K.P., Hebbring S.J., Wen C., Gorski M., Kim I.K., Cho D., Zack D., Souied E., Scholl H.P., Bala E., Lee K.E., Hunter D.J., Sardell R.J., Mitchell P., Merriam J.E., Cipriani V., Hoffman J.D., Schick T., Lechanteur Y.T., Guymer R.H., Johnson M.P., Jiang Y., Stanton C.M., Buitendijk G.H., Zhan X., Kwong A.M., Boleda A., Brooks M., Gieser L., Ratnapriya R., Branham K.E., Foerster J.R., Heckenlively J.R., Othman M.I., Vote B.J., Liang H.H., Souzeau E., McAllister I.L., Isaacs T., Hall J., Lake S., Mackey D.A., Constable I.J., Craig J.E., Kitchner T.E., Yang Z., Su Z., Luo H., Chen D., Ouyang H., Flagg K., Lin D., Mao G., Ferreyra H., Stark K., von Strachwitz C.N., Wolf A., Brandl C., Rudolph G., Olden M., Morrison M.A., Morgan D.J., Schu M., Ahn J., Silvestri G., Tsironi E.E., Park K.H., Farrer L.A., Orlin A., Brucker A., Li M., Curcio C.A., Mohand-Saïd S., Sahel J.A., Audo I., Benchaboune M., Cree A.J., Rennie C.A., Goverdhan S.V., Grunin M., Hagbi-Levi S., Campochiaro P., Katsanis N., Holz F.G., Blond F., Blanché H., Deleuze J.F., Igo R.P. Jr, Truitt B., Peachey N.S., Meuer S.M., Myers C.E., Moore E.L., Klein R., Hauser M.A., Postel E.A., Courtenay M.D., Schwartz S.G., Kovach J.L., Scott W.K., Liew G., Tan A.G., Gopinath B., Merriam J.C., Smith R.T., Khan J.C., Shahid H., Moore A.T., McGrath J.A., Laux R., Brantley M.A. Jr, Agarwal A., Ersoy L., Caramoy A., Langmann T., Saksens N.T., de Jong E.K., Hoyng C.B., Cain M.S., Richardson A.J., Martin T.M., Blangero J., Weeks D.E., Dhillon B., van Duijn C.M., Doheny K.F., Romm J., Klaver C.C., Hayward C., Gorin M.B., Klein M.L., Baird P.N., den Hollander A.I., Fauser S., Yates J.R., Allikmets R., Wang J.J., Schaumberg D.A., Klein B.E., Hagstrom S.A., Chowers I., Lotery A.J., Léveillard T., Zhang K., Brilliant M.H., Hewitt A.W., Swaroop A., Chew E.Y., Pericak-Vance M.A., DeAngelis M., Stambolian D., Haines J.L., Iyengar S.K., Weber B.H., Abecasis G.R., Heid I.M.: A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nature Genetics 48(2): 134-43, 2016.

Jia C., Hu Y., Liu Y., Li M.*: Mapping splicing quantitative trait loci using RNA-Seq. Cancer Informatics 14: 45-53, 2015 Notes: * Senior author; first author is Dr. Li's PhD student.

Ferguson J.F., Meyer N.J., Qu L., Xue C., Liu Y., DerOhannessian S.L., Rushefski M., Paschos G.K., Tang S., Schadt E.E., Li M., Christie J.D., Reilly M.P.: Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Human Molecular Genetics 24: 1801-1812, 2015.

Xu Z., Duan Q., Yan S., Chen W., Li M., Lange E., Li Y.: DISSCO: direct imputation of summary statistics allowing covariates. Bioinformatics 31: 2434-42, 2015.

Tian L., Kazmierkiewicz K.L., Bowman A.S., Li M., Curcio C.A., Stambolian D.E.: Transcriptome of the human retina, retinal pigmented epithelium and choroid. Genomics 105: 253-264, 2015.

Do R., Stitziel N.O., Won H.H., Jørgensen A.B., Duga S., Angelica Merlini P., Kiezun A., Farrall M., Goel A., Zuk O., Guella I., Asselta R., Lange L.A., Peloso G.M., Auer P.L.; NHLBI Exome Sequencing Project, Girelli D., Martinelli N., Farlow D.N., DePristo M.A., Roberts R., Stewart A.F., Saleheen D., Danesh J., Epstein S.E., Sivapalaratnam S., Hovingh G.K., Kastelein J.J., Samani N.J., Schunkert H., Erdmann J., Shah S.H., Kraus W.E., Davies R., Nikpay M., Johansen C.T., Wang J., Hegele R.A., Hechter E., Marz W., Kleber M.E., Huang J., Johnson A.D., Li M., Burke G.L., Gross M., Liu Y., Assimes T.L., Heiss G., Lange E.M., Folsom A.R., Taylor H.A., Olivieri O., Hamsten A., Clarke R., Reilly D.F., Yin W., Rivas M.A., Donnelly P., Rossouw J.E., Psaty B.M., Herrington D.M., Wilson J.G., Rich S.S., Bamshad M.J., Tracy R.P., Cupples L.A., Rader D.J., Reilly M.P., Spertus J.A., Cresci S., Hartiala J., Tang W.H., Hazen S.L., Allayee H., Reiner A.P., Carlson C.S., Kooperberg C., Jackson R.D., Boerwinkle E., Lander E.S., Schwartz S.M., Siscovick D.S., McPherson R., Tybjaerg-Hansen A., Abecasis G.R., Watkins H., Nickerson D.A., Ardissino D., Sunyaev S.R., O'Donnell C.J., Altshuler D., Gabriel S., Kathiresan S.: Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature 518: 102-106, 2015.

Wang X., Zhang S., Li Y., Li M., Sha Q.: A powerful approach to test an optimally weighted combination of rare variants in admixed populations. Genetic Epidemiology 39: 294-305, 2015 Notes: in press.

Hu M., Clark K., Gong X., Noudoost B., Li M., Moore T., Liang H. : Copula regression analysis of simultaneously recorded frontal eye field and inferotemporal spiking activity during object-based working memory. Journal of Neuroscience 2015 Notes: in press.

Zhang H., Xue C., Shah R., Bermingham K., Hinkle C.C., Li W., Rodrigues A., Tabita-Martinez J., Millar J., Cuchel M., Pashos E.E., Liu Y., Yan R., Yang W., Gosai S.J., VanDorn D., Chou S.T., Gregory B.D., Morrisey E.E., Li M., Rader D.J., Reilly M.P.: Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease. Circulation Research 117: 17-28, 2015.

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Last updated: 02/22/2016
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